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POU5F1 Gene

protein-coding   GIFtS: 69
GCID: GC06M031136

POU Class 5 Homeobox 1

(Previous names: POU domain class 5, transcription factor 1)
(Previous symbol: OTF3)
  See POU5F1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
POU Class 5 Homeobox 11 2     Oct-32 3
OTF31 2 3 5     Oct-42 3
OCT32 3 5     POU Domain Class 5, Transcription Factor 11
Octamer-Binding Protein 32 3     OTF42
Octamer-Binding Protein 42 3     POU Domain Transcription Factor OCT42
Octamer-Binding Transcription Factor 32 3     POU Domain, Class 5, Transcription Factor 12
OCT42 3     POU-Type Homeodomain-Containing DNA-Binding Protein2
OTF-32 3     

External Ids:    HGNC: 92211   Entrez Gene: 54602   Ensembl: ENSG000002045317   OMIM: 1641775   UniProtKB: Q018603   

Export aliases for POU5F1 gene to outside databases

Previous GC identifers: GC08P127435 GC06M031188 GC06M030902 GC06M031238 GC06M031240 GC06M031133 GC06M030934


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POU5F1 Gene:
This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic
development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with
tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which
also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation
initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations.
Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. (provided by RefSeq, Oct 2013)

GeneCards Summary for POU5F1 Gene:
POU5F1 (POU class 5 homeobox 1) is a protein-coding gene. Diseases associated with POU5F1 include central nervous system germinoma, and germinoma. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with
SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1,
FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency

Gene Wiki entry for POU5F1 (Oct-4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  
NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the POU5F1 gene promoter:
         AP-1   MyoD   STAT3   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): POU5F1 promoter sequence
   Search Chromatin IP Primers for POU5F1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU5F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.33

POU5F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU5F1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031136:  view genomic region     (about GC identifiers)

Start:
31,132,114 bp from pter      End:
31,148,508 bp from pter
Size:
16,395 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167245 2,429,238-2,435,593      Chr6-,NT_167246 2,480,458-2,486,814      Chr6-,NT_167248 2,427,966-2,434,320     
Chr6-,NT_113891.2 2,646,867-2,653,222      Chr6-,NT_167247 2,514,037-2,520,393      Chr6-,NT_167249 2,467,051-2,473,404     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860 (See protein sequence)
Recommended Name: POU domain, class 5, transcription factor 1  
Size: 360 amino acids; 38571 Da
Subunit: Interacts with UBE2I and ZSCAN10 (By similarity). Interacts with PKM. Interacts with WWP2
Developmental stage: Highly expressed in undifferentiated embryonic stem cells and expression decreases gradually
after embryoid body (EB) formation
Biotechnology: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors
are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent
stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes
Miscellaneous: Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. 2 of them,
localized in chromosomes 8 and 10, are transcribed in cancer tissues but not in normal ones and may be involved
in the regulation of POU5F1 gene activity in carcinogenesis
Secondary accessions: A6NCS1 A6NLL8 D2IYK4 P31359 Q15167 Q15168 Q16422 Q5STF3 Q5STF4
Alternative splicing: 2 isoforms:  Q01860-1   Q01860-2   

Explore the universe of human proteins at neXtProt for POU5F1: NX_Q01860

Explore proteomics data for POU5F1 at MOPED

Post-translational modifications: 

  • Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for
    enhanced YES1 expression (By similarity)1
  • Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation (By
    similarity)1
  • ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation
    at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POU5F1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001167002.1  NP_001272915.1  NP_001272916.1  NP_002692.2  NP_976034.4  

    ENSEMBL proteins: 
     ENSP00000389359   ENSP00000259915   ENSP00000425479   ENSP00000475880   ENSP00000475512  
     ENSP00000425083  
    Reactome Protein details: Q01860

    POU5F1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for POU5F1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for POU5F1 

    POU5F1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of POU5F1
    R&D Systems Antibodies for POU5F1 (Oct-4A, Oct-3/4)
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    Abcam antibodies for POU5F1
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    ThermoFisher Antibody for POU5F1
    LSBio Antibodies in human, mouse, rat for POU5F1

    POU5F1 Assay Products:

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    Cell Signaling Technology (CST) Sandwich ELISA Kits for POU5F1 (4-Oct)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for POU5F1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POU: Homeoboxes / POU class

    Selected InterPro protein domains (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry Q01860

    ProtoNet protein and cluster: Q01860

    2 Blocks protein domains:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860
    Domain: The POU-specific domain mediates interaction with PKM
    Similarity: Belongs to the POU transcription factor family. Class-5 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    Find genes that share domains with POU5F1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO5F1_HUMAN, Q01860
    Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with
    SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1,
    FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency
    Induction: Transcriptional activity is positively regulated by PKM

         Genatlas biochemistry entry for POU5F1:
    POU domain,class 5,transcription factor 1,expressed in neuronal cells,with OCT5 likely a proteolytic product of
    OCT3

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ISS--
    GO:0003677DNA binding IDA16153702
    GO:0003700sequence-specific DNA binding transcription factor activity IDA16153702
    GO:0005515protein binding IPI11099378
    GO:0008134transcription factor binding IPI19736317
         
    Find genes that share ontologies with POU5F1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for POU5F1:
     Increased gamma-H2AX phosphory 

         12 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Pou5f1):
     behavior/neurological  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     hematopoietic system  integument  liver/biliary system  mortality/aging  nervous system 
     normal  reproductive system 

    Find genes that share phenotypes with POU5F1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pou5f1tm1.1Scho for POU5F1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POU5F1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for POU5F1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU5F1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU5F1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  ATTTGCATAA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target POU5F1:
    hsa-mir-128-3p (MIRT022019), hsa-mir-145-5p (MIRT004904)

    Block miRNA regulation of human, mouse, rat POU5F1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate POU5F1:
    hsa-miR-3606 hsa-miR-3658 hsa-miR-103a-2* hsa-miR-3657 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidPOU5F1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for POU5F1
    Predesigned siRNA for gene silencing in human, mouse, rat POU5F1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for POU5F1 (see all 16)
    OriGene ORF clones in mouse, rat for POU5F1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): POU5F1 (NM_002701)
    Sino Biological Human cDNA Clone for POU5F1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU5F1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU5F1
    Addgene plasmids for POU5F1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for POU5F1
    ESI BIO Cell Lines for POU5F1: 
    Human Embryonic Stem Cell Line ESI-017, Human Embryonic Stem Cell Line ESI-035,
    Human Embryonic Stem Cell Line ESI-049, Human Embryonic Stem Cell Line ESI-051,
    Human Embryonic Stem Cell Line ESI-053
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU5F1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11760) for POU5F1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PO5F1_HUMAN, Q01860: Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18000303
    GO:0005654nucleoplasm IDA--
    GO:0005667transcription factor complex IDA19736317
    GO:0005737cytoplasm IDA18281244
    GO:0005829cytosol IDA18000303

    Find genes that share ontologies with POU5F1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POU5F1 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    2Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway and Pluripotency0.55
    3Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency0.50
    4Ca-dependent events
    Development Role of Activin A in cell differentiation and proliferation0.32
    5Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch


    Find genes that share SuperPaths with POU5F1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for POU5F1
        Transcriptional Regulatory Network in Embryonic Stem Cell
    Oct4 in Mammalian ESC Pluripotency
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency
    Human Early Embryo Development

    1 Cell Signaling Technology (CST) Pathway for POU5F1
        Wnt / Hedgehog / Notch

    1 GeneGo (Thomson Reuters) Pathway for POU5F1
        Development Role of Activin A in cell differentiation and proliferation

    4 BioSystems Pathways for POU5F1
        Wnt Signaling Pathway and Pluripotency
    SIDS Susceptibility Pathways
    Cardiac Progenitor Differentiation
    HIF-2-alpha transcription factor network


    3 Reactome Pathways for POU5F1
        POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
    Transcriptional regulation of pluripotent stem cells
    POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation


        Pathway & Disease-focused RT2 Profiler PCR Arrays including POU5F1 (see all 6): 
              Cell Lineage Identification in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for POU5F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for POU5F1 (Q018601, 2, 3 ENSP000002599154) via UniProtKB, MINT, STRING, and/or I2D (see all 229)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001714endodermal cell fate specification IDA--
    GO:0001824blastocyst development ISS--
    GO:0003130BMP signaling pathway involved in heart induction IMP19736317
    GO:0006355regulation of transcription, DNA-templated IDA16153702
    GO:0006366transcription from RNA polymerase II promoter ISS--

    Find genes that share ontologies with POU5F1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POU5F1 (PO5F1)

    2 DrugBank Compounds for POU5F1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DopamineDopamin (see all 6)51-61-6transportersubstrate20402963
    NorepinephrineArterenol (see all 4)51-41-2transportersubstrate20402963

    4 Novoseek inferred chemical compound relationships for POU5F1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    slex 56.7 5 16894532 (2), 19755485 (1), 15342930 (1), 20177991 (1)
    retinoic acid 36.8 13 1915274 (3), 7501302 (2), 12841847 (1), 19719918 (1) (see all 8)
    vegf 8.99 1 18729794 (1), 18332870 (1)
    oxygen 0 5 19755485 (1), 20177991 (1), 16510872 (1)



    Find genes that share compounds with POU5F1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POU5F1 gene (5 alternative transcripts): 
    NM_001173531.2  NM_001285986.1  NM_001285987.1  NM_002701.5  NM_203289.5  

    Unigene Cluster for POU5F1:

    POU class 5 homeobox 1
    Hs.249184  [show with all ESTs]
    Unigene Representative Sequence: NM_203289
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441888 ENST00000259915(uc003nsv.3) ENST00000512818(uc021yuj.1)
    ENST00000606567 ENST00000513407(uc003nsu.3) ENST00000471529 ENST00000461401

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    SwitchGear 3'UTR luciferase reporter plasmidPOU5F1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): POU5F1 (NM_002701)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU5F1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU5F1
    Addgene plasmids for POU5F1 
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    Additional mRNA sequence: 

    AM851115.1 AM851116.1 AM851117.1 AM851118.1 AM851119.1 AM851120.1 AM851121.1 AM851122.1 
    AM851123.1 AM851124.1 AM851125.1 AM851126.1 BC020712.1 BC069246.1 BC117435.1 BC117437.1 
    DQ486515.1 DQ486516.1 DQ486517.1 FM177951.1 FM177952.1 FM177953.1 FM177954.1 FM177955.1 
    FM177956.1 FM177957.1 FM177958.1 FM177959.1 FM177960.1 FM177961.1 FM177962.1 FM177963.1 
    FM177964.1 FM177965.1 FM177966.1 FM177967.1 FM177968.1 S81255.1 Z11898.1 Z11899.1 

    8 DOTS entries:

    DT.75142423  DT.100791936  DT.100018840  DT.102825540  DT.100791937  DT.121173762  DT.121322086  DT.75109570 

    9 AceView cDNA sequences:

    NM_203289 BC020712 Z11898 BC069246 Z11899 NM_002701 BF930231 BF871564 
    S81255 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    POU5F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCACTTTT
    POU5F1 Expression
    About this image


    POU5F1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 46) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 131 entries
             Inner Cell Mass Cells Inner Cell Mass
             CA2
             Matrigel embedded cells
             H1-GFP   
     
     Gonad
             Oogonia Ovigerous Cord
             Primordial germ-like cells
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 8 entries
             Primordial Germ Cell Precursors Epiblast
             Epiblast Stem Cells
             Epiblast-like cells
     
     Ovary (Reproductive System)    fully expand to see all 6 entries
             Oogonia Ovigerous Cord
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 6 entries
             Morula Cells Morula
    POU5F1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POU5F1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.249184

    UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860
    Tissue specificity: Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the
    olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including POU5F1 (see all 6): 
              Cell Lineage Identification in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for POU5F1
    OriGene qSTAR qPCR primer pairs in human, mouse for POU5F1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POU5F1
    QuantiTect SYBR Green Assays in human, mouse, rat POU5F1
    QuantiFast Probe-based Assays in human, mouse, rat POU5F1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU5F1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for POU5F1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou5f11 , 5 POU domain, class 5, transcription factor 11, 5 82.58(n)1
    84.66(a)1
      17 (18.69 cM)5
    189991  NM_013633.31  NP_038661.21 
     355060185 
    chicken
    (Gallus gallus)
    Aves POUV6
    Gallus gallus POU domain class 5 transcription fac...
    40(a)
    1 → many
    17(460123-461472)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    56(a)
    1 → many
    GL343623.1(305510-323263)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.232762 Xenopus laevis transcribed sequence with moderate similarity to protein pirS25561 (H.sapiens) S25561 transcription factor Oct-3, splice form Oct-3A - human less 80.05(n)    BQ900469.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pou5f12 POU domain, class 5, transcription factor 1 74.89(n)   30333  NM_131112.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta acj66
    abnormal chemosensory jump 6
    22(a)
    1 → many
    X(15245315-15272487)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-866
    Protein UNC-86, isoform a (unc-86) mRNA, complete ...
    26(a)
    1 → many
    III(8212758-8216336) WBGene00006818


    ENSEMBL Gene Tree for POU5F1 (if available)
    TreeFam Gene Tree for POU5F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POU5F1 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F12  POU3F42  POU1F12  POU3F32  
    POU4F32  POU3F22  POU2F22  POU5F1B2  POU4F12  POU2F12  POU6F12  
    14 SIMAP similar genes for POU5F1 using alignment to 53 protein entries:     PO5F1_HUMAN (see all proteins):
    POU5F1B    POU5F1P1    POU5F1P4    POU5F1P3    OCT6    POU2F3
    POU1F1    POU3F4    POU6F1    POU5F2    POU3F2    POU2F1
    POU2F2    POU3F1

    Find genes that share paralogs with POU5F1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for POU5F1 (see all 6)
    PGOHUM00000239313 PGOHUM00000245013 PGOHUM00000237756 PGOHUM00000238106 PGOHUM00000235313


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POU5F1 (see all 226)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs23948821,2
    C,F,A,H--31132649(+) CCTGCC/AAGTGA 3 -- int130Minor allele frequency- A:0.32NS EA NA WA CSA EU 4126
    rs92637951,2
    C,F,H--31132656(+) GTGAAT/CGACAG 3 -- int16Minor allele frequency- C:0.06EA NS NA EU 1607
    rs1919683711,2
    C,F--31132676(+) TGACAT/CTAGAC 3 -- int11Minor allele frequency- C:0.00EU 1063
    rs1827553761,2
    --31132710(+) CTGCTC/TGGACA 3 -- int10--------
    rs92637961,2
    C,F,H--31132883(+) GAGCCC/TGCAGA 3 -- int121Minor allele frequency- T:0.13NS EA NA WA CSA EU 3563
    rs178518181,2
    C,F--31132956(+) AGTGTG/CGGTTT 6 /P syn1 ese38Minor allele frequency- C:0.07NA EA WA EU 6766
    rs11507671,2,,4
    C,F,H--31133045(-) AAACCC/TTCGTG 6 L F mis1 ese310Minor allele frequency- T:0.03MN NS EA NA 922
    rs3682770841,2
    C--31133324(+) GTCCCC/TGGGTA 3 -- int10--------
    rs1152345111,2
    C,F--31133405(+) GGCCGC/AAGCTT 6 /L syn12Minor allele frequency- A:0.00WA NA 4448
    rs21060741,2
    C,F,O,A,H--31133509(-) CCTCAT/CTTTGC 3 -- int140Minor allele frequency- C:0.35EA NS NA WA CSA EU 5754

    HapMap Linkage Disequilibrium report for POU5F1 (31132114 - 31148508 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for POU5F1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731791CNV Deletion23290073
    nsv524061CNV Loss19592680
    nsv525933CNV Loss19592680
    nsv428140CNV Gain+Loss18775914
    esv690CNV CNV17122850
    dgv1919e1CNV Complex17122850
    dgv1918e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): POU5F1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POU5F1
    DNA2.0 Custom Variant and Variant Library Synthesis for POU5F1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164177    OMIM disorders: --

    9 diseases for POU5F1:    
    About MalaCards
    central nervous system germinoma    germinoma    seborrheic keratosis    pineoblastoma
    teratoma    sacrococcygeal teratoma    ovarian germ cell tumor    malignant germ cell tumor
    mixed germ cell tumor

    5 diseases from the University of Copenhagen DISEASES database for POU5F1:
    Teratoma     Gonadoblastoma     Embryonal carcinoma     Seminoma
    Dysgerminoma

    Find genes that share disorders with POU5F1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for POU5F1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 74.8 16 8662786 (2), 15725806 (1), 17314394 (1), 10328600 (1) (see all 13)
    teratoma 73.9 8 18439155 (1), 19826408 (1), 16494961 (1), 12161760 (1) (see all 8)
    pineoblastoma 46.3 1 15725806 (1)
    seminoma 44.6 4 15725806 (1), 17682839 (1), 17117392 (1)
    germinoma 36.7 6 15725806 (4), 17117392 (1)
    teratocarcinoma 33.4 1 8453995 (1)
    tumors 18 38 17205510 (5), 18701476 (3), 16510872 (3), 15513931 (2) (see all 22)
    cancer 17.3 23 17261754 (2), 16229821 (2), 16854382 (2), 18701476 (2) (see all 13)
    ewings sarcoma 16 3 15917470 (2), 20051954 (1), 17564582 (1)
    carcinoma 8.24 3 15342930 (1), 18614581 (1), 19876845 (1)

    Genetic Association Database (GAD): POU5F1
    Human Genome Epidemiology (HuGE) Navigator: POU5F1 (7 documents)

    Export disorders for POU5F1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POU5F1 gene, integrated from 10 sources (see all 540) (see top 10):
    (articles sorted by number of sources associating them with POU5F1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. (PubMed id 1408763)1, 2, 3, 9 Takeda J.... Bell G.I. (Nucleic Acids Res. 1992)
    2. Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. (PubMed id 18191611)1, 2, 9 Lee J.... Kim J. (Int. J. Biochem. Cell Biol. 2008)
    3. Oct4 pseudogenes are transcribed in cancers. (PubMed id 16229821)1, 2, 9 Suo G.... Dai J. (Biochem. Biophys. Res. Commun. 2005)
    4. A study of candidate genes for psoriasis near HLA-C in Chinese patients with psoriasis. (PubMed id 12653732)1, 4, 9 Chang Y.T....Wong C.K. (Br. J. Dermatol. 2003)
    5. Serine 111 phosphorylation regulates OCT4A protein subcellular distribution and degradation. (PubMed id 23024368)1, 2 Spelat R.... Curcio F. (J. Biol. Chem. 2012)
    6. Phosphorylation regulates human OCT4. (PubMed id 22474382)1, 2 Brumbaugh J.... Thomson J.A. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe. (PubMed id 21801394)1, 4 GAcnin E....Mockenhaupt M. (Orphanet J Rare Dis 2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    10. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    11. WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. (PubMed id 19274063)1, 2 Xu H.... Jin Y. (Cell Res. 2009)
    12. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PubMed id 16702430)1, 2 Shiina T.... Bahram S. (Genetics 2006)
    13. Expression of transcription regulating genes in human preimplantation embryos. (PubMed id 8567814)1, 2 Abdel-Rahman B.... Pergament E. (Hum. Reprod. 1995)
    14. A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. (PubMed id 7908264)1, 2 Wey E.... Schaefer B.W. (Eur. J. Biochem. 1994)
    15. Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation. (PubMed id 17525163)1, 9 Wei F....Atchison M.L. (J. Biol. Chem. 2007)
    16. Stimulation of Oct-4 activity by Ewing's sarcoma protein. (PubMed id 15917470)1, 9 Lee J....Kim J. (Stem Cells 2005)
    17. OCT-4, an embryonic stem cell marker, is highly expressed in bladder cancer. (PubMed id 17205510)1, 9 Atlasi Y....Bahrami A.R. (Int. J. Cancer 2007)
    18. Conserved and divergent patterns of expression of DAZL, VASA and OCT4 in the germ cells of the human fetal ovary and testis. (PubMed id 18088417)1, 9 Anderson R.A....Saunders P.T. (BMC Dev. Biol. 2007)
    19. Oct-4 controls cell-cycle progression of embryonic stem cells. (PubMed id 19968627)1, 9 Lee J....Kim J. (Biochem. J. 2010)
    20. Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4. (PubMed id 11689681)1, 9 Ezashi T....Roberts R.M. (Mol. Cell. Biol. 2001)
    21. Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension. (PubMed id 20139178)1, 9 Firth A.L....Yuan J.X. (Am. J. Physiol. Lung Cell Mol. Physiol. 2010)
    22. Oct4 is expressed in human gliomas and promotes colony formation in glioma cells. (PubMed id 18985733)1, 9 Du Z....Hao A. (Glia 2009)
    23. Effects of ectopic Nanog and Oct4 overexpression on mesenchymal stem cells. (PubMed id 19102659)1, 9 Liu T.M....Lim B. (Stem Cells Dev. 2009)
    24. Oct-4 expression in adult human differentiated cells challenges its role as a pure stem cell marker. (PubMed id 17379765)1, 9 Zangrossi S....Lazzari L. (Stem Cells 2007)
    25. The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells. (PubMed id 12841847)1, 9 Wang P....Jin T. (Biochem. J. 2003)
    26. Oct4 is expressed in Nestin-positive cells as a marker for pancreatic endocrine progenitor. (PubMed id 19224238)1, 9 Wang H....Li L. (Histochem. Cell Biol. 2009)
    27. Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract. (PubMed id 17314394)1, 9 Freberg C.T....Collas P. (Mol. Biol. Cell 2007)
    28. Transcriptional regulation of the Oct4 gene, a master gene for pluripotency. (PubMed id 20054811)1, 9 Kellner S. and Kikyo N. (Histol. Histopathol. 2010)
    29. Oct-4 expression in human endometrium. (PubMed id 16421218)1, 9 Matthai C....Kolbus A. (Mol. Hum. Reprod. 2006)
    30. Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer. (PubMed id 20101213)1, 9 Peng S....Huang Y. (Oncogene 2010)
    31. Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells. (PubMed id 18612434)1, 9 Chen Y.C....Chiou S.H. (PLoS ONE 2008)
    32. Transcriptional regulation of human Oct4 by steroidogenic factor-1. (PubMed id 17226773)1, 9 Yang H.M....Kim J.H. (J. Cell. Biochem. 2007)
    33. Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis. (PubMed id 15513931)1, 9 Tai M.H....Trosko J.E. (Carcinogenesis 2005)
    34. Specific knockdown of Oct4 and beta2-microglobulin expression by RNA interference in human embryonic stem cells and embryonic carcinoma cells. (PubMed id 15342930)1, 9 Matin M.M....Andrews P.W. (Stem Cells 2004)
    35. The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. (PubMed id 11891324)1, 9 Guo Y.... Hromas R. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    36. EWS-Oct-4B, an alternative EWS-Oct-4 fusion gene, is a potent oncogene linked to human epithelial tumours. (PubMed id 20051954)1, 9 Kim S....Kim J. (Br. J. Cancer 2010)
    37. Direct reprogramming of human neural stem cells by OCT4. (PubMed id 19718018)1, 9 Kim J.B....SchAPler H.R. (Nature 2009)
    38. Zfp143 regulates Nanog through modulation of Oct4 binding. (PubMed id 18687992)1, 9 Chen X....Ng H.H. (Stem Cells 2008)
    39. Oct-4, Rex-1, and Gata-4 expression in human MSC increase the differentiation efficiency but not hTERT expression. (PubMed id 17211834)1, 9 Roche S....Favrot M.C. (J. Cell. Biochem. 2007)
    40. POU5F1 isoforms show different expression patterns in human embryonic stem cells and preimplantation embryos. (PubMed id 16916925)1, 9 Cauffman G....Van de Velde H. (Stem Cells 2006)
    41. Sequential DNA methylation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differentiation. (PubMed id 15615706)1, 9 Deb-Rinker P....Walker P.R. (J. Biol. Chem. 2005)
    42. Relationships between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines. (PubMed id 19969351)1, 9 Marques D.S....Trindade G.S. (Leuk. Res. 2010)
    43. Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. (PubMed id 18593985)1, 9 Chiou S.H....Lo J.F. (Clin. Cancer Res. 2008)
    44. MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. (PubMed id 18806776)1, 9 Tay Y....Rigoutsos I. (Nature 2008)
    45. Evidence for the presence of stem cell-like progenitor cells in human adult pancreas. (PubMed id 18000303)1, 9 Zhao M....Huang G.C. (J. Endocrinol. 2007)
    46. Core transcriptional regulatory circuitry in human embryonic stem cells. (PubMed id 16153702)1, 9 Boyer L.A....Young R.A. (Cell 2005)
    47. Characterization of putative cis-regulatory elements that control the transcriptional activity of the human Oct4 promoter. (PubMed id 16149048)1, 9 Yang H.M....Kim J.H. (J. Cell. Biochem. 2005)
    48. Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. (PubMed id 12923055)1, 9 RemAcnyi A....Wilmanns M. (amp 2003)
    49. Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation. (PubMed id 19549847)1, 9 Papapetrou E.P....Sadelain M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    50. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. (PubMed id 18594515)1, 9 Kim J.B....SchAPler H.R. (Nature 2008)
    51. Independent prognostic value of the basal-like phenotype of breast cancer and associations with EGFR and candidate stem cell marker BMI-1. (PubMed id 18269588)1, 9 Arnes J.B....Akslen L.A. (Histopathology 2008)
    52. Immunohistochemical localization of nanog and Oct4 in stem cell compartments of human sacrococcygeal teratomas. (PubMed id 18439155)1, 9 Busch C....Drews U. (Histopathology 2008)
    53. Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. (PubMed id 18388306)1, 9 Fong H....Donovan P.J. (Stem Cells 2008)
    54. Aberrant expression and distribution of the OCT-4 transcription factor in seminomas. (PubMed id 17682839)1, 9 Cheng C.J....Huang Y.H. (J. Biomed. Sci. 2007)
    55. Cytoplasmic OCT4 staining is a sensitive marker of neuroendocrine differentiation. (PubMed id 24182453)1 Alexander R.E....Idrees M.T. (Hum. Pathol. 2014)
    56. Unique kinetics of Oct3/4 microlocalization following dissociation of human embryonic stem cell colonies. (PubMed id 22727933)1 Ichikawa H....Sasaki K. (Ann. Anat. 2013)
    57. Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. (PubMed id 23955597)1 Chubb D....Goldschmidt H. (Nat. Genet. 2013)
    58. OCT4 increases BIRC5 and CCND1 expression and promotes cancer progression in hepatocellular carcinoma. (PubMed id 23433354)1 Cao L....Su C. (BMC Cancer 2013)
    59. PSCA and Oct-4 expression in the benign and malignant lesions of gallbladder: implication for carcinogenesis, progression, and prognosis of gallbladder adenocarcinoma. (PubMed id 23984394)1 Zou Q....Fu X. (Biomed Res Int 2013)
    60. I^-Catenin/POU5F1/SOX2 transcription factor complex mediates IGF-I receptor signaling and predicts poor prognosis in lung adenocarcinoma. (PubMed id 23539445)1 Xu C....Bian X.W. (Cancer Res. 2013)
    61. Human organic cation transporters 1 (SLC22A1), 2 (SLC22A2), and 3 (SLC22A3) as disposition pathways for fluoroquinolone antimicrobials. (PubMed id 23545524)1 Mulgaonkar A....Sweet D.H. (Antimicrob. Agents Chemother. 2013)
    62. Knockdown of Oct4 and Nanog expression inhibits the stemness of pancreatic cancer cells. (PubMed id 23872274)1 Lu Y....Wang Z. (Cancer Lett. 2013)
    63. Forced expression of OCT4 influences the expression of pluripotent genes in human mesenchymal stem cells and fibroblasts. (PubMed id 23613252)1 Palma C.S....PicanAso-Castro V. (Genet. Mol. Res. 2013)
    64. Increased chemosensitivity via targeting testicular nuclear receptor 4 (TR4)-Oct4-interleukin 1 receptor antagonist (IL1Ra) axis in prostate cancer CD133+ stem/progenitor cells to battle prostate cancer. (PubMed id 23609451)1 Yang D.R....Chang C. (J. Biol. Chem. 2013)
    65. Characterization of mesenchymal stem cell subpopulations from human amniotic membrane with dissimilar osteoblastic potential. (PubMed id 23211052)1 Leyva-Leyva M....Fuentes-Mera L. (Stem Cells Dev. 2013)
    66. Suppression of OCT4B Enhances Sensitivity of Lung Adenocarcinoma A549 Cells to Cisplatin via Increased Apoptosis. (PubMed id 24324071)1 Cortes-Dericks L....Karoubi G. (Anticancer Res. 2013)
    67. Pluripotent stem cell transcription factors during human odontogenesis. (PubMed id 23736381)1 da Cunha J.M....da Silva M.C. (Cell Tissue Res. 2013)
    68. C-MYC controlled TIP110 protein expression regulates OCT4 mRNA splicing in human embryonic stem cells. (PubMed id 23088399)1 Liu Y....He J.J. (Stem Cells Dev. 2013)
    69. Downregulation of OCT4 promotes differentiation and inhibits growth of BE (2)-C human neuroblastoma I-type cells. (PubMed id 23525564)1 Yang L....Xiao X. (Oncol. Rep. 2013)
    70. Prognostication of OCT4 isoform expression in prostate cancer. (PubMed id 23636800)1 de Resende M.F....Rocha R.M. (Tumour Biol. 2013)
    71. Immunohistochemical analysis of the role and relationship between Notch-1 and Oct-4 expression in urinary bladder carcinoma. (PubMed id 23594289)1 Abdou A.G....Elkady N. (APMIS 2013)
    72. OCT4 is epigenetically regulated by DNA hypomethylation of promoter and exon in primary gliomas. (PubMed id 23670345)1 Shi J....Zhu J. (Oncol. Rep. 2013)
    73. Enrichment in c-Kit+ enhances mesodermal and neural differentiation of human chorionic placental cells. (PubMed id 23643069)1 Resca E....De Pol A. (Placenta 2013)
    74. Itch, an E3 ligase of Oct4, is required for embryonic stem cell self-renewal and pluripotency induction. (PubMed id 23255053)1 Liao B....Jin Y. (J. Cell. Physiol. 2013)
    75. Differential expression of Oct4 variants and pseudogenes in normal urothelium and urothelial cancer. (PubMed id 23933063)1 Wezel F....Southgate J. (Am. J. Pathol. 2013)
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    216. Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells. (PubMed id 20458727)1 Trubiani O....Nanci A. (J. Cell. Physiol. 2010)
    217. TIF1beta regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner. (PubMed id 20508149)1 Seki Y....Asashima M. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    218. Phosphorylated nucleolin interacts with translationally controlled tumor protein during mitosis and with Oct4 during interphase in ES cells. (PubMed id 21048921)1 Johansson H....Simonsson S. (PLoS ONE 2010)
    219. Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells. (PubMed id 19966271)1 Qiu C....Huang Y. (Nucleic Acids Res. 2010)
    220. A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells. (PubMed id 20505821)1 Yang J....Ma Y. (PLoS ONE 2010)
    221. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. (PubMed id 20953172)1 Chia N.Y.... Ng H.H. (Nature 2010)
    222. OCT-4 expression in follicular and luteal phase endometrium: a pilot study. (PubMed id 20412569)1 Bentz E.K....Tempfer C.B. (amp 2010)
    223. Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer A549 cells. (PubMed id 20074550)1 Teng Y....Ma D. (Biochem. Biophys. Res. Commun. 2010)
    224. Reprogramming towards pluripotency requires AID-dependent DNA demethylation. (PubMed id 20027182)1 Bhutani N....Blau H.M. (Nature 2010)
    225. Generation of human-induced pluripotent stem cells from gut mesentery-derived cells by ectopic expression of OCT4/SOX2/NANOG. (PubMed id 20698766)1 Li Y....Li L. (Cell Reprogram 2010)
    226. Single-molecule analysis reveals changes in the DNA replication program for the POU5F1 locus upon human embryonic stem cell differentiation. (PubMed id 20647538)1 Schultz S.S....Schildkraut C.L. (Mol. Cell. Biol. 2010)
    227. Comparison of MHC class I risk haplotypes in Thai and Caucasian psoriatics shows locus heterogeneity at PSORS1. (PubMed id 20604894)2 Stuart P.E.... Elder J.T. (Tissue Antigens 2010)
    228. Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5. (PubMed id 21151833)1 Hawkins P.G. and Morris K.V. (Transcription 2010)
    229. Newer insights into premeiotic development of germ cells in adult human testis using Oct-4 as a stem cell marker. (PubMed id 20805580)1 Bhartiya D....Tongaonkar H.B. (J. Histochem. Cytochem. 2010)
    230. Atypical expression and distribution of embryonic stem cell marker, OCT4, in human lung adenocarcinoma. (PubMed id 20721963)1 Karoubi G....Schmid R.A. (J Surg Oncol 2010)
    231. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    232. Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach. (PubMed id 20103622)1 Mattison J....Adams D.J. (Cancer Res. 2010)
    233. Alternative translation of OCT4 by an internal ribosome entry site and its novel function in stress response. (PubMed id 19489092)1 Wang X....Dai J. (Stem Cells 2009)
    234. Mutation in the DNA-binding domain of the EWS-Oct-4 oncogene results in dominant negative activity that interferes with EWS-Oct-4-mediated transactivation. (PubMed id 19170206)1 Kim S....Kim J. (Int. J. Cancer 2009)
    235. A method for isolating pluripotent/multipotent stem cells from blood by using the pluripotent and germ-line DAZL gene as a marker. (PubMed id 19327014)1 Seligman J....Fabian I. (Stem Cells Dev. 2009)
    236. Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy. (PubMed id 19657699)1 Saigusa S....Kusunoki M. (Ann. Surg. Oncol. 2009)
    237. Genes involved in regulation of stem cell properties: studies on their expression in a small cohort of neuroblastoma patients. (PubMed id 19458492)1 Melone M.A....Galderisi U. (amp 2009)
    238. Embryonic stem cell transcription factors and D2-40 (podoplanin) as diagnostic immunohistochemical markers in ovarian germ cell tumors. (PubMed id 19483629)1 Chang M.C....Nucci M.R. (Int. J. Gynecol. Pathol. 2009)
    239. A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. (PubMed id 19171782)1 Kang J....Tantin D. (amp 2009)
    240. Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. (PubMed id 19816951)1 Wei Z....Lu W. (Stem Cells 2009)
    241. Specific knockdown of OCT4 in human embryonic stem cells by inducible short hairpin RNA interference. (PubMed id 19350677)1 Zafarana G....Andrews P.W. (Stem Cells 2009)
    242. OCT4 expression in human non-small cell lung cancer: implications for therapeutic intervention. (PubMed id 19126554)1 Karoubi G....Dutly A. (Interact Cardiovasc Thorac Surg 2009)
    243. Implication of human OCT4 transactivation domains for self-regulatory transcription. (PubMed id 19445899)1 Lim H.Y....Kim J.H. (Biochem. Biophys. Res. Commun. 2009)
    244. BMP-11 and myostatin support undifferentiated growth of human embryonic stem cells in feeder-free cultures. (PubMed id 19751112)1 Hannan N.R....Wolvetang E.J. (Cloning Stem Cells 2009)
    245. O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development. (PubMed id 19383152)1 Webster D.M....Dougan S.T. (BMC Dev. Biol. 2009)
    246. Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells. (PubMed id 19884257)1 Yuan P....Ng H.H. (amp 2009)
    247. Regulation of adipose tissue stromal cells behaviors by endogenic Oct4 expression control. (PubMed id 19777066)1 Kim J.H....Kang S.K. (PLoS ONE 2009)
    248. MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. (PubMed id 19409607)1 Xu N....Kosik K.S. (Cell 2009)
    249. Oct4, a novel marker for human gastric cancer. (PubMed id 19347886)1 Chen Z....Xu X.J. (J Surg Oncol 2009)
    250. OCT4A contributes to the stemness and multi-potency of human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs). (PubMed id 19394308)1 Seo K.W....Kang K.S. (Biochem. Biophys. Res. Commun. 2009)
    251. Mesenchymal to embryonic incomplete transition of human cells by chimeric OCT4/3 (POU5F1) with physiological co-activator EWS. (PubMed id 19559696)1 Makino H....Umezawa A. (Exp. Cell Res. 2009)
    252. Direct cell reprogramming is a stochastic process amenable to acceleration. (PubMed id 19898493)1 Hanna J....Jaenisch R. (Nature 2009)
    253. Oct4A is expressed by a subpopulation of prostate neuroendocrine cells. (PubMed id 19058139)1 Sotomayor P....Huss W.J. (Prostate 2009)
    254. Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells. (PubMed id 19528230)1 Sun C....Yokota T. (Mol. Cell. Biol. 2009)
    255. Analysis of OCT4 expression in an extended panel of human tumor cell lines from multiple entities and in human mesenchymal stem cells. (PubMed id 19023518)1 Mueller T....Mueller L.P. (Cell. Mol. Life Sci. 2009)
    256. The expression of pluripotency marker Oct 3/4 in prostate cancer and benign prostate hyperplasia. (PubMed id 19274762)1 Monsef N....Panagopoulos I. (Prostate 2009)
    257. Oct3/4 and Sox2 are significantly associated with an unfavorable clinical outcome in human esophageal squamous cell carcinoma. (PubMed id 19414369)1 Wang Q....Suo Z. (Anticancer Res. 2009)
    258. Oct-4A isoform is expressed in human cord blood-derived CD133 stem cells and differentiated progeny. (PubMed id 19438894)1 Howe M....Denner L. (Cell Prolif. 2009)
    259. iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism. (PubMed id 19696409)1 Martinez-Fernandez A....Terzic A. (Circ. Res. 2009)
    260. Involvement of the organic cation transporters in histamine uptake into human vascular endothelial cells. (PubMed id 19271143)1 Cerne K. and Krzan M. (Inflamm. Res. 2009)
    261. Testicular mixed germ cell tumors: a morphological and immunohistochemical study using stem cell markers, OCT3/4, SOX2 and GDF3, with emphasis on morphologically difficult-to-classify areas. (PubMed id 19396148)1 Gopalan A....Tickoo S.K. (Mod. Pathol. 2009)
    262. Role of Oct-4 during acquisition of developmental competence in mouse oocyte. (PubMed id 20034424)1 Zuccotti M....Garagna S. (Reprod. Biomed. Online 2009)
    263. Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. (PubMed id 19736317)1 Stefanovic S....PucAcat M. (J. Cell Biol. 2009)
    264. The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting. (PubMed id 19536159)1 Donohoe M.E....Lee J.T. (Nature 2009)
    265. Expression of transcription factor Oct4 in bladder cancer cell line T24 and its effects on the biological characteristics of the cells. (PubMed id 19224167)1 Zhu Z....Fan C. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2009)
    266. Oct4-induced pluripotency in adult neural stem cells. (PubMed id 19203577)1 Kim J.B....SchAPler H.R. (Cell 2009)
    267. Oct4 is epigenetically regulated by methylation in normal placenta and gestational trophoblastic disease. (PubMed id 18440631)1 Zhang H.J....Cheung A.N. (Placenta 2008)
    268. Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. (PubMed id 18710938)1 Card D.A....Archer T.K. (Mol. Cell. Biol. 2008)
    269. Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. (PubMed id 18281244)1 Kristensen D.M....Leffers H. (Hum. Reprod. 2008)
    270. OCT4 spliced variants are differentially expressed in human pluripotent and nonpluripotent cells. (PubMed id 18787205)1 Atlasi Y.... Andrews P.W. (Stem Cells 2008)
    271. Participation of OCT3/4 and beta-catenin during dysgenetic gonadal malignant transformation. (PubMed id 18295396)1 Palma I....Queipo G. (Cancer Lett. 2008)
    272. [Identification of the OCT4-pg1 retrogene and NANOG gene expression in the human embryonic eye]. (PubMed id 18946985)1 Firsova N.V....Mitashov V.I. (Izv. Akad. Nauk. Ser. Biol. 2008)
    273. Identification of karyopherin-alpha 2 as an Oct4 associated protein. (PubMed id 19103427)1 Li X....Jin Y. (J Genet Genomics 2008)
    274. Induced pluripotent stem cells generated without viral integration. (PubMed id 18818365)1 Stadtfeld M....Hochedlinger K. (Science 2008)
    275. Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci. (PubMed id 17573914)1 BA!rtovA! E....Kozubek S. ( research in biological diversity 2008)
    276. Epigenetic deregulation of the human Oct4 promoter in mouse cells. (PubMed id 18810488)1 Cha Y....Park K.S. (Dev. Genes Evol. 2008)
    277. Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity. (PubMed id 18339675)1 Endoh M....Koseki H. (Development 2008)
    278. In vivo osteoprogenitor potency of human stromal cells from different tissues does not correlate with expression of POU5F1 or its pseudogenes. (PubMed id 18617685)1 Kaltz N....Oostendorp R.A. (Stem Cells 2008)
    279. Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells. (PubMed id 18676852)1 Chang C.C....Wu C.L. (Cancer Res. 2008)
    280. Identification of DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays. (PubMed id 18366076)1 Chakravarthy H....Rizzino A. (J. Cell. Physiol. 2008)
    281. The early human germ cell lineage does not express SOX2 during in vivo development or upon in vitro culture. (PubMed id 18199879)1 Perrett R.M....Hanley N.A. (Biol. Reprod. 2008)
    282. Absence of OCT4 expression in somatic tumor cell lines. (PubMed id 18032701)1 Cantz T....SchAPler H.R. (Stem Cells 2008)
    283. Differential expression of the embryo/cancer gene ECSA(DPPA2), the cancer/testis gene BORIS and the pluripotency structural gene OCT4, in human preimplantation development. (PubMed id 18467432)1 Monk M....Hawes S. (Mol. Hum. Reprod. 2008)
    284. The transcription factor Zfp281 controls embryonic stem cell pluripotency by direct activation and repression of target genes. (PubMed id 18757296)1 Wang Z.X....Stanton L.W. (Stem Cells 2008)
    285. Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells. (PubMed id 19060217)1 Yang J....Ma Y. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    286. Simultaneous expression of Oct4 and genes of three germ layers in single cell-derived multipotent adult progenitor cells. (PubMed id 18338169)1 Ji K.H....Liu H.Q. (Ann. Hematol. 2008)
    287. Sequence variation in the human transcription factor gene POU5F1. (PubMed id 18254969)1 Hussain S.K....Schwartz S.M. (BMC Genet. 2008)
    288. Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. (PubMed id 18957414)1 Zhang X....Pei D. (J. Biol. Chem. 2008)
    289. Novel variants of Oct-3/4 gene expressed in mouse somatic cells. (PubMed id 18765667)1 Mizuno N. and Kosaka M. (J. Biol. Chem. 2008)
    290. Reprogramming of human somatic cells to pluripotency with defined factors. (PubMed id 18157115)1 Park I.H....Daley G.Q. (Nature 2008)
    291. Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs. (PubMed id 17390031)1 Katoh M. and Katoh M. (Int. J. Oncol. 2007)
    292. Functional similarities among genes regulated by OCT4 in human mesenchymal and embryonic stem cells. (PubMed id 17761754)1 Greco S.J....Rameshwar P. (Stem Cells 2007)
    293. A novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung. (PubMed id 17923501)1 Chen Y....Lin C.L. (J. Exp. Med. 2007)
    294. Differential methylation of the OCT3/4 upstream region in primary human testicular germ cell tumors. (PubMed id 17549357)1 De Jong J....Looijenga L.H. (Oncol. Rep. 2007)
    295. Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. (PubMed id 17982423)1 McGowan S.L....Whikehart D.R. (Mol. Vis. 2007)
    296. Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. (PubMed id 17273778)1 Katoh Y. and Katoh M. (Int. J. Oncol. 2007)
    297. Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells. (PubMed id 17068183)1 Babaie Y....Adjaye J. (Stem Cells 2007)
    298. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. (PubMed id 18035408)2 Takahashi K....Yamanaka S. (Cell 2007)
    299. Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal. (PubMed id 17506876)1 Greber B....Adjaye J. (BMC Dev. Biol. 2007)
    300. Risk alleles for multiple sclerosis identified by a genomewide study. (PubMed id 17660530)4  ....Hauser S.L. (N. Engl. J. Med. 2007)
    301. Expression and significance of Oct4 in bladder cancer. (PubMed id 18231740)1 Xu K....Zeng F. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2007)
    302. Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis? (PubMed id 17413979)1 Howell N.R....Liang S.X. (Int. J. Gynecol. Pathol. 2007)
    303. Manipulation of OCT4 levels in human embryonic stem cells results in induction of differential cell types. (PubMed id 17959850)1 Rodriguez R.T....Firpo M.T. (Exp. Biol. Med. (Maywood) 2007)
    304. Oct-3/4: not just a gatekeeper of pluripotency for embryonic stem cell, a cell fate instructor through a gene dosage effect. (PubMed id 17245123)1 Stefanovic S. and PucAcat M. (Cell Cycle 2007)
    305. The genetic polymorphisms of POU5F1 gene are associated with psoriasis vulgaris in Chinese. (PubMed id 17314032)1 Chang Y.T....Tsai S.F. (J. Dermatol. Sci. 2007)
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    313. Loss of Oct-3/4 expression in embryonal carcinoma cells is associated with induction of cisplatin resistance. (PubMed id 16557044)1 Mueller T....Schmoll H.J. (Tumour Biol. 2006)
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    317. EWSR1 is fused to POU5F1 in a bone tumor with translocation t(6;22)(p21;q12). (PubMed id 15729702)1 Yamaguchi S....Nakamura T. (amp 2005)
    318. Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro. (PubMed id 15790780)1 Moriscot C....Benhamou P.Y. (Stem Cells 2005)
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    320. Stably transfected human embryonic stem cell clones express OCT4-specific green fluorescent protein and maintain self-renewal and pluripotency. (PubMed id 15625129)1 Gerrard L....Cui W. (Stem Cells 2005)
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    329. Oct-1 preferentially interacts with androgen receptor in a DNA-dependent manner that facilitates recruitment of SRC-1. (PubMed id 11096094)1 Gonzalez M.I. and Robins D.M. (J. Biol. Chem. 2001)
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    355. Expression of Scl in mesoderm rescues hematopoiesis in the absence of Oct-4. (PubMed id 19321862)9 Kong K.Y....Dahl R. (Blood 2009)
    356. Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data. (PubMed id 18522731)9 Sharov A.A....Ko M.S. (BMC Genomics 2008)
    357. Platypus Pou5f1 reveals the first steps in the evolution of trophectoderm differentiation and pluripotency in mammals. (PubMed id 19021737)9 Niwa H....GrA1tzner F. (amp 2008)
    358. Cloning and characterization of the rabbit POU5F1 gene. (PubMed id 17852331)9 Shi J.J....Sheng H.Z. (DNA Seq. 2008)
    359. Post-translational regulation of Oct4 transcriptional activity. (PubMed id 19221599)9 Saxe J.P....Huang J. (PLoS ONE 2009)
    360. HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. (PubMed id 16510872)9 Covello K.L....Keith B. (amp 2006)
    361. Induction of dedifferentiation, genomewide transcriptional programming, and epigenetic reprogramming by extracts of carcinoma and embryonic stem cells. (PubMed id 16195347)9 Taranger C.K....Collas P. (Mol. Biol. Cell 2005)
    362. Transcriptional regulation of nanog by OCT4 and SOX2. (PubMed id 15860457)9 Rodda D.J....Robson P. (J. Biol. Chem. 2005)
    363. Oct-4 expression in inner cell mass and trophectoderm of human blastocysts. (PubMed id 11044462)9 Hansis C....Krey L.C. (Mol. Hum. Reprod. 2000)
    364. Oct-4: control of totipotency and germline determination. (PubMed id 10694754)9 Pesce M. and SchAPler H.R. (Mol. Reprod. Dev. 2000)
    365. Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites. (PubMed id 9343393)9 Ambrosetti D.C....Dailey L. (Mol. Cell. Biol. 1997)
    366. Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. (PubMed id 19584295)9 Levings P.P....Gibbs C.P. (Cancer Res. 2009)
    367. The EWS-Oct-4 fusion gene encodes a transforming gene. (PubMed id 17564582)9 Lee J....Kim J. (Biochem. J. 2007)
    368. Redox regulation of the embryonic stem cell transcription factor oct-4 by thioredoxin. (PubMed id 15153603)9 Guo Y....Hromas R. (Stem Cells 2004)
    369. Comparative analysis of human, bovine, and murine Oct-4 upstream promoter sequences. (PubMed id 11309664)9 Nordhoff V....SchAPler H.R. (Mamm. Genome 2001)
    370. Synergism with germ line transcription factor Oct-4: viral oncoproteins share the ability to mimic a stem cell-specific activity. (PubMed id 10082529)9 Brehm A....SchAPler H.R. (Mol. Cell. Biol. 1999)
    371. Molecular cloning, genetic mapping, and developmental expression of bovine POU5F1. (PubMed id 10208969)9 van Eijk M.J....Gandolfi F. (Biol. Reprod. 1999)
    372. Targeting of de novo DNA methylation throughout the Oct-4 gene regulatory region in differentiating embryonic stem cells. (PubMed id 20376339)9 Athanasiadou R....Bird A. (PLoS ONE 2010)
    373. Oct-4 regulates the expression of Stella and Foxj2 at the Nanog locus: implications for the developmental competence of mouse oocytes. (PubMed id 19477878)9 Zuccotti M....Garagna S. (Hum. Reprod. 2009)
    374. Oxytocin receptor- and Oct-4-expressing cells in human amniotic fluid. (PubMed id 18569033)9 Stefanidis K....Antsaklis A. (Gynecol. Endocrinol. 2008)
    375. Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. (PubMed id 18662995)9 van den Berg D.L....Poot R.A. (Mol. Cell. Biol. 2008)
    376. Gonadotropins affect Oct-4 gene expression during mouse oocyte growth. (PubMed id 16496425)9 Monti M....Zuccotti M. (Mol. Reprod. Dev. 2006)
    377. Expression of endoderm stem cell markers: evidence for the presence of adult stem cells in human thyroid glands. (PubMed id 16839255)9 Thomas T....Derwahl M. (Thyroid 2006)
    378. Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies. (PubMed id 16854382)9 Hoffmann M.J....Schulz W.A. (Biochem. Pharmacol. 2006)
    379. [Effect of nicotine on Oct-4 transcription of embryonic stem cells]. (PubMed id 15612475)9 Zhang H....Qia Z. (Wei Sheng Yan Jiu 2004)
    380. A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. (PubMed id 19345177)9 Ding L.... Buchholz F. (Cell Stem Cell 2009)
    381. Neuron-like differentiation and selective ablation of undifferentiated embryonic stem cells containing suicide gene with Oct-4 promoter. (PubMed id 18393636)9 Hara A....Mori H. (Stem Cells Dev. 2008)
    382. Oct-4: the almighty POUripotent regulator? (PubMed id 17228302)9 Buitrago W. and Roop D.R. (J. Invest. Dermatol. 2007)
    383. Molecular cloning and function of Oct-3 isoforms in cynomolgus monkey embryonic stem cells. (PubMed id 16978059)9 Fujimoto Y....Nakatsuji N. (Stem Cells Dev. 2006)
    384. From adult stem cells to cancer stem cells: Oct-4 Gene, cell-cell communication, and hormones during tumor promotion. (PubMed id 17261754)9 Trosko J.E. (Ann. N. Y. Acad. Sci. 2006)
    385. Activation of ectopic Oct-4 and Rex-1 promoters in human amniotic fluid cells. (PubMed id 16273276)9 Karlmark K.R....HengstschlAoger M. (Int. J. Mol. Med. 2005)
    386. Developmental incompetency of denuded mouse oocytes undergoing maturation in vitro is ooplasmic in nature and is associated with aberrant Oct-4 expression. (PubMed id 15817588)9 Chang H.C....Krey L.C. (Hum. Reprod. 2005)
    387. Oct-4 regulates alternative platelet-derived growth factor alpha receptor gene promoter in human embryonal carcinoma cells. (PubMed id 8662786)9 Kraft H.J....van Zoelen E.J. (J. Biol. Chem. 1996)
    388. The octamer motif present in the Rex-1 promoter binds Oct-1 and Oct-3 expressed by EC cells and ES cells. (PubMed id 7945330)9 Rosfjord E. and Rizzino A. (Biochem. Biophys. Res. Commun. 1994)
    389. Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions. (PubMed id 19755485)9 Forristal C.E....Houghton F.D. (Reproduction 2010)
    390. Epigenetic changes to human umbilical cord blood cells cultured with three proteins indicate partial reprogramming to a pluripotent state. (PubMed id 20096686)9 Wong C.J....Rogers I.M. (Exp. Cell Res. 2010)
    391. Isolation and characterization of mesenchymal stem cells from the sub-amniotic human umbilical cord lining membrane. (PubMed id 19635009)9 Kita K....Jeschke M.G. (Stem Cells Dev. 2010)
    392. Characterization of somatic cell nuclear reprogramming by oocytes in which a linker histone is required for pluripotency gene reactivation. (PubMed id 20212135)9 Jullien J....Gurdon J.B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    393. Parthenogenetic embryo-like structures in the human ovarian surface epithelium cell culture in postmenopausal women with no naturally present follicles and oocytes. (PubMed id 18605894)9 Virant-Klun I....Meden-Vrtovec H. (Stem Cells Dev. 2009)
    394. Cloning and characterization of cat POU5F1 and NANOG for identification of embryonic stem-like cells. (PubMed id 19293558)9 Yu X.F....Kong I.K. (J. Reprod. Dev. 2009)
    395. Cross-regulation of the Nanog and Cdx2 promoters. (PubMed id 19564890)9 Chen L....Daley G.Q. (Cell Res. 2009)
    396. Quantitative transcription factor analysis of undifferentiated single human embryonic stem cells. (PubMed id 19815608)9 StAYhlberg A....Semb H. (Clin. Chem. 2009)
    397. A core Klf circuitry regulates self-renewal of embryonic stem cells. (PubMed id 18264089)9 Jiang J....Ng H.H. (Nat. Cell Biol. 2008)
    398. IFATS collection: Selenium induces improvement of stem cell behaviors in human adipose-tissue stromal cells via SAPK/JNK and stemness acting signals. (PubMed id 18583539)9 Kim J.H....Kang S.K. (Stem Cells 2008)
    399. A computational model for understanding stem cell, trophectoderm and endoderm lineage determination. (PubMed id 18941526)9 Chickarmane V. and Peterson C. (PLoS ONE 2008)
    400. Isolation of human bone marrow mesenchymal stem cells using different membrane markers: comparison of colony/cloning efficiency, differentiation potential, and molecular profile. (PubMed id 18800875)9 Kastrinaki M.C....Papadaki H.A. (Tissue Eng Part C Methods 2008)
    401. Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells. (PubMed id 17352742)9 Hattori N....Shiota K. (amp 2007)
    402. Isolation and characterization of EG-like cells from Chinese swamp buffalo (Bubalus bubalis). (PubMed id 17532234)9 Huang B....Li M.M. (Cell Biol. Int. 2007)
    403. Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation. (PubMed id 17288545)9 Battula V.L....BA1hring H.J. ( research in biological diversity 2007)
    404. Bovine embryonic stem cells. (PubMed id 17141027)9 Roach M....Tian X.C. (Meth. Enzymol. 2006)
    405. Undifferentiated mouse mesenchymal stem cells spontaneously express neural and stem cell markers Oct-4 and Rex-1. (PubMed id 16793732)9 Lamoury F.M....Brew B.J. (Cytotherapy 2006)
    406. Developmental expression of pluripotency determining factors in caprine embryos: novel pattern of NANOG protein localization in the nucleolus. (PubMed id 16894532)9 He S....Keefer C. (Mol. Reprod. Dev. 2006)
    407. Comparisons between transcriptional regulation and RNA expression in human embryonic stem cell lines. (PubMed id 16846370)9 Player A....Kawasaki E.S. (Stem Cells Dev. 2006)
    408. Derivation of human embryonic stem cells from developing and arrested embryos. (PubMed id 16990582)9 Zhang X....Stojkovic M. (Stem Cells 2006)
    409. Comparative genomics on SOX2 orthologs. (PubMed id 16077994)9 Katoh Y. and Katoh M. (Oncol. Rep. 2005)
    410. Monitoring differentiation of human embryonic stem cells using real-time PCR. (PubMed id 16081663)9 Noaksson K....Sartipy P. (Stem Cells 2005)
    411. Comparative genomics on mammalian Fgf3-Fgf4 locus. (PubMed id 15942670)9 Katoh M. and Katoh M. (Int. J. Oncol. 2005)
    412. Transcription factor Sox-2 inhibits co-activator stimulated transcription. (PubMed id 15349837)9 Bernadt C.T....Rizzino A. (Mol. Reprod. Dev. 2004)
    413. Oct-4-expressing cells in human amniotic fluid: a new source for stem cell research? (PubMed id 12832377)9 Prusa A.R....HengstschlAoger M. (Hum. Reprod. 2003)
    414. Establishment of SSEA-1- and Oct-4-expressing rat embryonic stem-like cell lines and effects of cytokines of the IL-6 family on clonal growth. (PubMed id 10896787)9 Vassilieva S....Wobus A.M. (Exp. Cell Res. 2000)
    415. Effects of differentiation on the transcriptional regulation of the FGF-4 gene: critical roles played by a distal enhancer. (PubMed id 9740330)9 Lamb K.A. and Rizzino A. (Mol. Reprod. Dev. 1998)
    416. Phosphorylation and DNA binding of the octamer binding transcription factor Oct-3. (PubMed id 7626120)9 Rosfjord E....Rizzino A. (Biochem. Biophys. Res. Commun. 1995)
    417. Identification of differentially expressed mRNAs during neuronal differentiation of P19 embryonal carcinoma cells. (PubMed id 7501302)9 Suzuki Y....Takagi T. (Neurosci. Res. 1995)
    418. Changes in Hox1.6, c-jun, and Oct-3 gene expressions are associated with teratocarcinoma F9 cell differentiation in three different ways of induction. (PubMed id 8453995)9 Iwai S.A....Nishimune Y. (Exp. Cell Res. 1993)
    419. The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer. (PubMed id 1915274)9 Okazawa H....Hamada H. (EMBO J. 1991)
    420. Identification of the transactivation domain of the transcription factor Sox-2 and an associated co-activator. (PubMed id 10660531)9 Nowling T.K....Rizzino A. (J. Biol. Chem. 2000)
    421. Differential expression profiling between atypical teratoid/rhabdoid and medulloblastoma tumor in vitro and in vivo using microarray analysis. (PubMed id 19902219)9 Ma H.I....Wong T.T. (Childs Nerv Syst 2010)
    422. CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells. (PubMed id 20190812)9 Gao M.Q....Cho N.H. (Oncogene 2010)
    423. Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development. (PubMed id 19915186)9 Yamada M....Umezawa A. (Hum. Mol. Genet. 2010)
    424. Analysis of SOX2 expression in developing human testis and germ cell neoplasia. (PubMed id 19876845)9 Sonne S.B....Rajpert-De-Meyts E. (Int. J. Dev. Biol. 2010)
    425. The effect of human embryonic stem cells (hESCs) long-term normoxic and hypoxic cultures on the maintenance of pluripotency. (PubMed id 20177991)9 Zachar V....Fink T. (amp 2010)
    426. Cryopreservation of primate embryonic stem cells with chemically-defined solution without Me2SO. (PubMed id 19857481)9 Nishigaki T....Iwata H. (Cryobiology 2010)
    427. DHP-derivative and low oxygen tension effectively induces human adipose stromal cell reprogramming. (PubMed id 20161735)9 Jee M.K....Kang S.K. (PLoS ONE 2010)
    428. Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling. (PubMed id 19880964)9 Spee B....Roskams T. (Gut 2010)
    429. Lentivirus-modified human umbilical cord mesenchymal stem cells maintain their pluripotency. (PubMed id 19961436)9 Qian H....Sun J. (Biotechnol. Appl. Biochem. 2010)
    430. Isolation and characterization of stem cells derived from human third molar tooth germs of young adults: implications in neo-vascularization, osteo-, adipo- and neurogenesis. (PubMed id 19721467)9 Yalvac M.E....Kose G.T. (Pharmacogenomics J. 2010)
    431. Efficient derivation of Chinese human embryonic stem cell lines from frozen embryos. (PubMed id 20186511)9 Li C....Jin Y. (amp 2010)
    432. FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. (PubMed id 19897487)9 Moreno-Manzano V....SA!nchez-Puelles J.M. (J. Biol. Chem. 2010)
    433. Human adipose-derived mesenchymal stem cells in vitro: evaluation of an optimal expansion medium preserving stemness. (PubMed id 19929458)9 Baer P.C....Geiger H. (Cytotherapy 2010)
    434. Generation of induced pluripotent stem cells from newborn marmoset skin fibroblasts. (PubMed id 20363201)9 Wu Y....Hornsby P.J. (Stem Cell Res 2010)
    435. Generation of human induced pluripotent stem cells from a Bombay individual: moving towards &quot;universal-donor&quot; red blood cells. (PubMed id 19912985)9 Seifinejad A....Baharvand H. (Biochem. Biophys. Res. Commun. 2010)
    436. In vitro differentiation of GABAergic cells from bone marrow stromal cells using potassium chloride as inducer. (PubMed id 20479529)9 Gharibani P.M....Arabkheradmand J. (Restor. Neurol. Neurosci. 2010)
    437. Embryonic-like stem cell derived from adult bone marrow: immature morphology, cell surface markers, ultramicrostructure and differentiation into multinucleated fibers in vitro. (PubMed id 20385079)9 Pang R....Zhang C. (Cell. Mol. Biol. (Noisy-le-grand) 2010)
    438. Isolation of multipotent stem cells in human periodontal ligament using stage-specific embryonic antigen-4. (PubMed id 19945209)9 Kawanabe N....Yamashiro T. ( research in biological diversity 2010)
    439. Astaxanthin improves the proliferative capacity as well as the osteogenic and adipogenic differentiation potential in neural stem cells. (PubMed id 20385192)9 Kim J.H....Choi Y.H. (Food Chem. Toxicol. 2010)
    440. Regulatory circuits underlying pluripotency and reprogramming. (PubMed id 19427042)9 Do J.T. and SchAPler H.R. (Trends Pharmacol. Sci. 2009)
    441. Endothelial cell differentiation of human breast tumour stem/progenitor cells. (PubMed id 18410528)9 Bussolati B....Camussi G. (J. Cell. Mol. Med. 2009)
    442. Statins inhibit the growth of variant human embryonic stem cells and cancer cells in vitro but not normal human embryonic stem cells. (PubMed id 19438511)9 Gauthaman K....Bongso A. (Br. J. Pharmacol. 2009)
    443. Neural ganglioside GD2 identifies a subpopulation of mesenchymal stem cells in umbilical cord. (PubMed id 19471109)9 Xu J....Han Z. (Cell. Physiol. Biochem. 2009)
    444. [Analysis on the expression of the stem cells related genes in hepatocellular carcinoma cell lines]. (PubMed id 19719918)9 Zou C....Zhang Y.S. (Zhonghua Gan Zang Bing Za Zhi 2009)
    445. A tumorigenic homeobox (HOX) gene expressing human gastric cell line derived from putative gastric stem cell. (PubMed id 19424076)9 Yang Y.C....Wu D.C. (amp 2009)
    446. Acetylation of sox2 induces its nuclear export in embryonic stem cells. (PubMed id 19591226)9 Baltus G.A....Kadam S. (Stem Cells 2009)
    447. Ex vivo expansion of adipose tissue-derived stem cells in spinner flasks. (PubMed id 19404993)9 Zhu Y....Cui Z. (Biotechnol J 2009)
    448. Generation of induced pluripotent stem cells by reprogramming human fibroblasts with the stemgent human TF lentivirus set. (PubMed id 19997062)9 Wu D....Yao S. (J Vis Exp 2009)
    449. Generation of induced pluripotent stem cells from neural stem cells. (PubMed id 19798081)9 Kim J.B....SchAPler H.R. (Nat Protoc 2009)
    450. Self-renewal and pluripotency is maintained in human embryonic stem cells by co-culture with human fetal liver stromal cells expressing hypoxia inducible factor 1alpha. (PubMed id 19492421)9 Ji L....Pei X.T. (J. Cell. Physiol. 2009)
    451. [Effects of different culture conditions on isolation and expansion of stem cells from second-trimester amniotic fluids]. (PubMed id 19570457)9 Liu H....Pei X.T. (Zhonghua Fu Chan Ke Za Zhi 2009)
    452. In vitro propagation and characterization of neoplastic stem/progenitor-like cells from human prostate cancer tissue. (PubMed id 19644960)9 GuzmA!n-RamA-rez N....Cecchini M.G. (Prostate 2009)
    453. Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. (PubMed id 19826408)9 Chan E.M....Schlaeger T.M. (Nat. Biotechnol. 2009)

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