Aliases for POU4F3 Gene
External Ids for POU4F3 Gene
Previous HGNC Symbols for POU4F3 Gene
Previous GeneCards Identifiers for POU4F3 Gene
This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009]
GeneCards Summary for POU4F3 Gene
POU4F3 (POU Class 4 Homeobox 3) is a Protein Coding gene. Diseases associated with POU4F3 include Deafness, Autosomal Dominant 15 and Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is POU4F2.
UniProtKB/Swiss-Prot for POU4F3 Gene
Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5-ATGCAAAT-3 in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear.