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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU4F2 Gene

protein-coding   GIFtS: 53
GCID: GC04P147560

POU Class 4 Homeobox 2

(Previous names: POU domain, class 4, transcription factor 2, POU domain...)
(Previous symbol: BRN3B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
POU Class 4 Homeobox 21 2     brain-3B2
BRN3B1 2 3 5     Brn3b POU Domain Transcription Factor2
POU Domain, Class 4, Transcription Factor 21 2     POU Domain Class 4 Transcription Factor 22
Brain-Specific Homeobox/POU Domain Protein 3B2 3     POU Domain Protein2
POU Domain Class 4, Transcription Factor 21     Brain-3B3
BRN3.22     Brn-3B3
Brn-3b2     

External Ids:    HGNC: 92191   Entrez Gene: 54582   Ensembl: ENSG000001516157   OMIM: 1137255   UniProtKB: Q128373   

Export aliases for POU4F2 gene to outside databases

Previous GC identifers: GC04P148362 GC04P147935 GC04P148137 GC04P147917 GC04P147779 GC04P143287


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POU4F2 Gene:
The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in
maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority
of breast cancers, resulting in accelerated tumor growth. (provided by RefSeq, Sep 2011)

GeneCards Summary for POU4F2 Gene: 
POU4F2 (POU class 4 homeobox 2) is a protein-coding gene. Diseases associated with POU4F2 include chordoid glioma, and differentiating neuroblastoma. GO annotations related to this gene include chromatin binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO4F2_HUMAN, Q12837
Function: Transcription factor. May play a role in determining or maintaining the identities of a small subset of
visual system neurons

Gene Wiki entry for POU4F2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU4F2 gene promoter:
         CRE-BP1   SRY   Ik-2   p53   ATF-2   NRSF form 1   NRSF form 2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOU4F2 promoter sequence
   Search SABiosciences Chromatin IP Primers for POU4F2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU4F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.2   Ensembl cytogenetic band:  4q31.22   HGNC cytogenetic band: 4q31.22

POU4F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU4F2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P147560:  view genomic region     (about GC identifiers)

Start:
147,560,045 bp from pter      End:
147,563,626 bp from pter
Size:
3,582 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PO4F2_HUMAN, Q12837 (See protein sequence)
Recommended Name: POU domain, class 4, transcription factor 2  
Size: 409 amino acids; 43087 Da
Subcellular location: Nucleus speckle
Secondary accessions: B1PJR6 B2RC84 Q13883 Q14987

Explore the universe of human proteins at neXtProt for POU4F2: NX_Q12837

Explore proteomics data for POU4F2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12837

  • POU4F2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    POU4F2 Protein Expression
    REFSEQ proteins: NP_004566.2  
    ENSEMBL proteins: 
     ENSP00000281321  

    Human Recombinant Protein Products for POU4F2: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0016607nuclear speck IEA--

    POU4F2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    POU: Homeoboxes / POU class

    5/6 InterPro protein domains (see all 6):
     IPR010982 Lambda_DNA-bd_dom
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry Q12837

    ProtoNet protein and cluster: Q12837

    2 Blocks protein domains:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO4F2_HUMAN, Q12837
    Domain: The polyhistidine repeat acts as a targeting signal to nuclear speckles (PubMed:19266028)
    Similarity: Belongs to the POU transcription factor family. Class-4 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    POU4F2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO4F2_HUMAN, Q12837
    Function: Transcription factor. May play a role in determining or maintaining the identities of a small subset of
    visual system neurons

         Genatlas biochemistry entry for POU4F2:
    POU domain,class 4,transcription factor 2,expressed in a subset of retinal ganglion cells

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA--
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription ISS--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
         
    POU4F2 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Pou4f2):
     behavior/neurological  cellular  hearing/vestibular/ear  nervous system  normal 
     vision/eye 

    POU4F2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for POU4F2: Pou4f2tm1Nat Pou4f2tm1Rsd

       inGenious Targeting Laboratory - Custom generated mouse model solutions for POU4F2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POU4F2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU4F2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU4F2 

    miRNA
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    miRTarBase miRNAs that target POU4F2:
    hsa-mir-214 (MIRT005551), hsa-mir-23a (MIRT003856)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU4F2
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate POU4F2 (see all 34):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-379* hsa-miR-30d hsa-miR-138-2* hsa-miR-374c hsa-miR-30a hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidPOU4F2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU4F2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for POU4F2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Direct p53 effectors
    Direct p53 effectors


    1 BioSystems Pathway for POU4F2
        Direct p53 effectors


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU4F2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for POU4F2 (Q128373 ENSP000002813214) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR1P033723, ENSP000002062494I2D: score=5 STRING: ENSP00000206249
    ALX4Q9H1613I2D: score=1 
    MIXL1Q9H2W23I2D: score=1 
    POU6F1Q148633I2D: score=1 
    BAXENSP000002932884STRING: ENSP00000293288
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0000165MAPK cascade IDA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007409axonogenesis ----
    GO:0007411axon guidance ISS--

    POU4F2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POU4F2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POU4F2 (PO4F2)

    3 Novoseek inferred chemical compound relationships for POU4F2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    isoleucine 34.6 3 8662774 (1), 9223099 (1)
    valine 26.8 3 8662774 (1), 9223099 (1)
    estrogen 0 1 15833836 (1)

    Search CenterWatch for drugs/clinical trials and news about POU4F2 / PO4F2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POU4F2 gene: 
    NM_004575.2  

    Unigene Cluster for POU4F2:

    POU class 4 homeobox 2
    Hs.266  [show with all ESTs]
    Unigene Representative Sequence: NM_004575
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000281321(uc003ikv.3)
    miRNA
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    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate POU4F2 (see all 34):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-379* hsa-miR-30d hsa-miR-138-2* hsa-miR-374c hsa-miR-30a hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidPOU4F2 3' UTR sequence
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU4F2

    Additional mRNA sequence: 

    AK314982.1 BC136344.1 BC136345.1 EU439706.1 L20434.1 U06233.1 X71488.1 

    1 DOTS entry:

    DT.404512 

    7 AceView cDNA sequences:

    BM728968 L20434 X71488 NM_004575 BU736562 AL045162 U06233 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU4F2 expression in normal human tissues (normalized intensities)      POU4F2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    POU4F2 Expression
    About this image


    POU4F2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Ganglion Cells Ganglion Cell Layer
     
     Neural Tube (Nervous System)
             Mesencephalon
     
     Brain (Nervous System)
             midbrain   

    See POU4F2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POU4F2

    SOURCE GeneReport for Unigene cluster: Hs.266

    UniProtKB/Swiss-Prot: PO4F2_HUMAN, Q12837
    Tissue specificity: Brain. Seems to be specific to the retina

        SABiosciences Expression via Pathway-Focused PCR Arrays including POU4F2: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Stem Cell Transcription Factors in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU4F2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for POU4F2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou4f21 , 5 POU domain, class 4, transcription factor 21, 5 90.55(n)1
    98.04(a)1
      8 (36.99 cM)5
    189971  NM_138944.21  NP_620394.21 
     784330095 
    chicken
    (Gallus gallus)
    Aves BRN36
    Brain-specific homeobox/POU domain protein 3
    72(a)
    possible ortholog
    4(11065971-11071035)
    zebrafish
    (Danio rerio)
    Actinopterygii pou4f21 POU domain, class 4, transcription factor 2 79.18(n)
    88.98(a)
      402816  NM_212807.1  NP_997972.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta acj63 synaptic target recognition RNA
    polymerase II more
    49(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea unc-863 Pou homeodomain 75(a)   III(8284820-8288362)   --


    ENSEMBL Gene Tree for POU4F2 (if available)
    TreeFam Gene Tree for POU4F2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POU4F2 gene
    POU5F22  POU6F22  POU2F32  POU3F12  POU3F42  POU1F12  POU3F32  POU4F32  
    POU3F22  POU2F22  POU5F1B2  POU4F12  POU2F12  POU6F12  POU5F12  
    6 SIMAP similar genes for POU4F2 using alignment to 1 protein entry:     PO4F2_HUMAN:
    POU4F3    POU6F1    POU5F1P4    POU4F1    POU1F1    POU3F1

    POU4F2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/182 SNPs in POU4F2 are shown (see all 182)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs65374281,2
    C--147558072(+) TCCCTG/ACCCCA 1 -- us2k112Minor allele frequency- A:0.00NA WA CSA EA 378
    rs1409440461,2
    C--147558090(+) GTTTCG/TCTGAG 1 -- us2k10--------
    rs1446009941,2
    --147558098(+) GAGCTC/TACACC 1 -- us2k10--------
    rs1884936201,2
    --147558158(+) CTCCAC/TACAGG 1 -- us2k10--------
    rs19105951,2
    C,F--147558237(-) AGCGCG/TCGACG 1 -- us2k16Minor allele frequency- T:0.08NA WA EA 364
    rs768321021,2
    C,F--147558243(+) GCGCTC/TGTTGC 1 -- us2k12Minor allele frequency- T:0.14NA EA 240
    rs1151342691,2
    F--147558244(+) CGCTCG/TTTGCT 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1924717921,2
    --147558553(+) TTCCTA/GCGTCG 1 -- us2k10--------
    rs1850855671,2
    --147558563(+) GGGGTC/TCCGGG 1 -- us2k10--------
    rs37628421,2
    C,F,A--147558564(-) CCCCGG/CGACCC 1 -- us2k14Minor allele frequency- C:0.15NA WA EA 242

    HapMap Linkage Disequilibrium report for POU4F2 (147560045 - 147563626 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for POU4F2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv880238CNV Loss21882294
    nsv822768CNV Gain20364138
    nsv830107CNV Gain17160897
    nsv461675CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 113725    OMIM disorders: --

    14 diseases for POU4F2:    About MalaCards
    chordoid glioma    differentiating neuroblastoma    herpes simplex    wilms tumor
    breast cancer    neuroblastoma    papilloma    systemic lupus erythematosus
    glaucoma    neuronitis    cervical cancer    lupus erythematosus
    retinitis    cervicitis


    POU4F2 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for POU4F2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    latent infection 42.1 1 10224669 (1)
    wilms tumor 33.3 1 12609742 (1)
    papilloma 29.3 2 9541499 (1)
    herpes simplex 23.6 1 10224669 (1)
    breast cancer 22.4 26 17637757 (4), 14726699 (3), 16152597 (3), 16441225 (2) (see all 6)
    tumors 0 7 14970234 (1), 16152597 (1)


    Export disorders for POU4F2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU4F2 gene, integrated from 9 sources (see all 58) (see top 10):
    (articles sorted by number of sources associating them with POU4F2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain. (PubMed id 8332509)1, 2, 3 Ring C.J.A. and Latchman D.S. (1993)
    2. Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. (PubMed id 7691107)1, 2, 9 Xiang M.... Nathans J. (1993)
    3. Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. (PubMed id 8234287)1, 2 Bhargava A.K.... Weissman S.M. (1993)
    4. The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo. (PubMed id 14970234)1, 9 Irshad S....Budhram-Mahadeo V. (2004)
    5. The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells. (PubMed id 16152597)1, 9 Samady L....Latchman D.S. (2006)
    6. Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter. (PubMed id 15833836)1, 9 Lee S.A....Budhram-Mahadeo V.S. (2005)
    7. Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells. (PubMed id 17637757)1, 9 Budhram-Mahadeo V.S....Latchman D.S. (2008)
    8. Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor. (PubMed id 14726699)1, 9 Samady L....Latchman D.S. (2004)
    9. The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells. (PubMed id 11526481)1, 9 Dennis J.H....Latchman D.S. (2001)
    10. The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. (PubMed id 7623109)1, 9 Xiang M.... Nathans J. (1995)
    11. Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor. (PubMed id 8995448)1, 9 Smith M.D....Latchman D.S. (1997)
    12. Diagnosis of bladder cancer recurrence based on urinar y levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation. (PubMed id 23056278)1 Reinert T....Dyrskjot L. (2012)
    13. Hsp-27 induction requires POU4F2/Brn-3b TF in doxorub icin-treated breast cancer cells, whereas phosphorylation alters its cellular l ocalisation following drug treatment. (PubMed id 21279488)1 Fujita R....Budhram-Mahadeo V.S. (2011)
    14. Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment. (PubMed id 19266028)2 Salichs E.... de la Luna S. (2009)
    15. A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors. (PubMed id 18367606)1 Qiu F....Xiang M. (2008)
    16. Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells. (PubMed id 17490655)1 Calissano M....Latchman D.S. (2007)
    17. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    18. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PubMed id 16368877)1 Choy K.W....Pang C.P. (2006)
    19. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    20. Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells. (PubMed id 15968082)1 Weishaupt J.H....Bahr M. (2005)
    21. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    22. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    23. Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina. (PubMed id 12724837)1 de Melo J....Eisenstat D.D. (2003)
    24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    25. POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element. (PubMed id 9448000)1 Budhram-Mahadeo V....Latchman D.S. (1998)
    26. The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b). (PubMed id 12609742)9 Wagner K.D....Scholz H. (2003)
    27. Elevated expression of the Brn-3a and Brn-3b transcription factors in systemic lupus erythematosus correlates with antibodies to Brn-3 and overexpression of Hsp90. (PubMed id 15818685)9 Ripley B.J....Latchman D.S. (2005)
    28. Targeting Brn-3b in breast cancer therapy. (PubMed id 16441225)9 Budhram-Mahadeo V.S. and Latchman D.S. (2006)
    29. Quantitative ex vivo detection of rodent retinal ganglion cells by immunolabeling Brn-3b. (PubMed id 15183108)9 Leahy K.M....Wax M.B. (2004)
    30. Distinct responses of the herpes simplex virus and varicella zoster virus immediate early promoters to the cellular transcription factors Brn-3a and Brn-3b. (PubMed id 10224669)9 Brownlees J....Latchman D.S. (1999)
    31. The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain. (PubMed id 7935408)9 Morris P.J....Latchman D.S. (1994)
    32. The functionally antagonistic POU family transcription factors Brn-3a and Brn-3b show opposite changes in expression during the growth arrest and differentiation of human neuroblastoma cells. (PubMed id 8782654)9 Smith M.D. and Latchman D.S. (1996)
    33. Differential regulation of neuronal nicotinic acetylcholine receptor subunit gene promoters by Brn-3 POU family transcription factors. (PubMed id 8713067)9 Milton N.G....Latchman D.S. (1996)
    34. The levels of the antagonistic POU family transcription factors Brn-3a and Brn-3b in neuronal cells are regulated in opposite directions by serum growth factors. (PubMed id 7731552)9 Budhram-Mahadeo V....Latchman D.S. (1995)
    35. The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells. (PubMed id 10597274)9 Budhram-Mahadeo V....Latchman D.S. (1999)
    36. The HPV-activating cellular transcription factor Brn-3a is overexpressed in CIN3 cervical lesions. (PubMed id 9541499)9 Ndisdang D....Latchman D.S. (1998)
    37. A single residue within the homeodomain of the Brn-3 POU family transcription factors determines whether they activate or repress the SNAP-25 promoter. (PubMed id 9223099)9 Morris P.J....Latchman D.S. (1997)
    38. A single amino acid change converts an inhibitory transcription factor into an activator. (PubMed id 8662774)9 Dawson S.J....Latchman D.S. (1996)
    39. Activation of the alpha-internexin promoter by the Brn-3a transcription factor is dependent on the N-terminal region of the protein. (PubMed id 7852360)9 Budhram-Mahadeo V....Latchman D.S. (1995)
    40. The DNA target site for the Brn-3 POU family transcription factors can confer responsiveness to cyclic AMP and removal of serum in neuronal cells. (PubMed id 8065921)9 Budhram-Mahadeo V....Latchman D.S. (1994)
    41. The Wilms' tumor gene Wt1 is required for normal development of the retina. (PubMed id 11889045)9 Wagner K.D....Scholz H. (2002)
    42. POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification. (PubMed id 10357904)9 Gan L....Klein W.H. (1999)
    43. Coordinate induction of the three neurofilament genes by the Brn-3a transcription factor. (PubMed id 9261145)9 Smith M.D....Latchman D.S. (1997)
    44. Similarities and differences among inner retinal neurons revealed by the expression of reporter transgenes controlled by Brn-3a, Brn-3b, and Brn-3c promotor sequences. (PubMed id 8903036)9 Xiang M....Nathans J. (1996)
    45. Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding. (PubMed id 8537352)9 Theil T....Moroy T. (1995)
    46. The neuronal nicotinic acetylcholine receptor alpha 2 subunit gene promoter is activated by the Brn-3b POU family transcription factor and not by Brn-3a or Brn-3c. (PubMed id 7797498)9 Milton N.G....Latchman D.S. (1995)
    47. Coupling the transcriptional regulatory action of Brn-3b to the cell cycle clock. (PubMed id 15020847)9 Zhu T. and Sukumar S. (2004)
    48. Activation of the iNOS gene promoter by Brn-3 POU family transcription factors is dependent upon the octamer motif in the promoter. (PubMed id 9878805)9 Gay R.D....Latchman D.S. (1998)
    49. The Brn-3c transcription factor contains a neuronal-specific activation domain. (PubMed id 9579678)9 Smith M.D....Latchman D.S. (1998)
    50. Activation and repression of gene expression by POU family transcription factors. (PubMed id 8735273)9 Latchman D.S. (1996)
    51. Math5 promotes retinal ganglion cell expression patterns in retinal progenitor cells. (PubMed id 17653051)9 Yao J....Qian J. (2007)
    52. The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1. (PubMed id 15021903)9 Gascoyne D.M....Latchman D.S. (2004)
    53. The Brn-3a transcription factor plays a key role in regulating the growth of cervical cancer cells in vivo. (PubMed id 11521202)9 Ndisang D....Latchman D.S. (2001)
    54. Evidence that POU factor Brn-3B regulates expression of Pax-6 in neuroretina cells. (PubMed id 10526314)9 Plaza S....Dozier C. (1999)
    55. The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. (PubMed id 8972215)9 Smith M.D....Latchman D.S. (1997)
    56. The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements. (PubMed id 8670054)9 Dawson S.J....Latchman D.S. (1996)
    57. Differential regulation of genes encoding synaptic proteins by members of the Brn-3 subfamily of POU transcription factors. (PubMed id 9037543)9 Morris P.J....Latchman D.S. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5458 HGNC: 9219 AceView: POU4F2 Ensembl:ENSG00000151615 euGenes: HUgn5458
    ECgene: POU4F2 H-InvDB: POU4F2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POU4F2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POU4F2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    Patent Information for POU4F2 gene:
    Search GeneIP for patents involving POU4F2

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