POU4F2 Gene

Aliases
for POU4F2 gene

Previous GC identifers: GC04P148362 GC04P147935 GC04P148137 GC04P147917 GC04P147779 GC04P143287

Summaries
for POU4F2 gene

Genomic Views
for POU4F2 gene

RefSeq DNA sequence:

NC_000004.11  NC_018915.1  NT_016354.19  

SwitchGear Promoter luciferase reporter plasmid: POU4F2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU4F2

POU4F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P147560:  view genomic region     (about GC identifiers)

Proteins
for POU4F2 gene

Explore the universe of human proteins at neXtProt for POU4F2: NX_Q12837

Post-translational modifications:

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	Uscn Proteins for POU4F2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

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	Uscn Antibodies for POU4F2
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	Uscn ELISAs and CLIAs for POU4F2

Protein Domains /
Families
for POU4F2 gene

ProtoNet protein and cluster: Q12837

Function
for POU4F2 gene

miRNA Products:		miRTarBase miRNAs that target POU4F2: hsa-mir-214 (MIRT005551), hsa-mir-23a (MIRT003856)
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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU4F2
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate POU4F2 (see all 34):
		hsa-miR-411* hsa-miR-323-3p hsa-miR-379* hsa-miR-30d hsa-miR-138-2* hsa-miR-374c hsa-miR-30a hsa-miR-186
		SwitchGear 3'UTR luciferase reporter plasmid: POU4F2 3' UTR sequence

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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for POU4F2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU4F2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 9 alleles) (MGI details for Pou4f2)

Pathways & Interactions
for POU4F2 gene

	Super-pathway	contained gene-specific pathways
1	Direct p53 effectors	Direct p53 effectors 1.00

1 BioSystems Pathway for POU4F2

Direct p53 effectors

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

Drugs & Compounds
for POU4F2 gene

Transcripts
for POU4F2 gene

Expression
for POU4F2 gene

POU4F2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

3 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	EyeGanglion Cell LayerImmature Ganglion Cells			Ganglion, Retina
	EyeGanglion Cell LayerMature Ganglion Cells			Ganglion, Retina
	EyeGanglion Cell LayerGanglion Precursor Cells			Ganglion, Retina
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Retinal cells (Generation of retina...)

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU4F2

Orthologs
for POU4F2 gene

Paralogs
for POU4F2 gene

Paralogs for POU4F2 gene

POU5F2²  POU6F2²  POU2F3²  POU3F4²  POU3F1²  POU1F1²  POU4F3²  POU3F3²  

POU3F2²  POU2F2²  POU5F1B²  POU2F1²  POU4F1²  POU5F1²  POU6F1²  

8 SIMAP similar genes for POU4F2 using alignment to 1 protein entry:     PO4F2_HUMAN:

POU4F3    POU6F1    POU5F1P4    POU4F1    POU1F1    POU3F1

POU3F2    POU3F3

POU4F2 for paralogs           About GeneDecksing

Genomic Variants
for POU4F2 gene

Disorders / Diseases
for POU4F2 gene

13 diseases for POU4F2

6 Novoseek disease relationships for POU4F2 gene    About this table

Publications
for POU4F2 gene

PubMed articles for POU4F2 gene integrated from 9 sources (see top 10): (articles sorted by number of sources associating them with POU4F2)

Utopia: connect your pdf to the dynamic world of online information

1. The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain. (PubMed id 8332509)^{1, 2, 3} Ring C.J.A. and Latchman D.S. (1993)
2. Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. (PubMed id 7691107)^{1, 2, 9} Xiang M.... Nathans J. (1993)
3. Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. (PubMed id 8234287)^{1, 2} Bhargava A.K.... Weissman S.M. (1993)
4. The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo. (PubMed id 14970234)^{1, 9} Irshad S....Budhram-Mahadeo V. (2004)
5. The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells. (PubMed id 16152597)^{1, 9} Samady L....Latchman D.S. (2006)
6. Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter. (PubMed id 15833836)^{1, 9} Lee S.A....Budhram-Mahadeo V.S. (2005)
7. Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells. (PubMed id 17637757)^{1, 9} Budhram-Mahadeo V.S....Latchman D.S. (2008)
8. Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor. (PubMed id 14726699)^{1, 9} Samady L....Latchman D.S. (2004)
9. The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells. (PubMed id 11526481)^{1, 9} Dennis J.H....Latchman D.S. (2001)
10. The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. (PubMed id 7623109)^{1, 9} Xiang M.... Nathans J. (1995)
11. Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor. (PubMed id 8995448)^{1, 9} Smith M.D....Latchman D.S. (1997)
12. Hsp-27 induction requires POU4F2/Brn-3b TF in doxorub icin-treated breast cancer cells, whereas phosphorylation alters its cellular l ocalisation following drug treatment. (PubMed id 21279488)¹ Fujita R....Budhram-Mahadeo V.S. (2011)
13. Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment. (PubMed id 19266028)² Salichs E.... de la Luna S. (2009)
14. A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors. (PubMed id 18367606)¹ Qiu F....Xiang M. (2008)
15. Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells. (PubMed id 17490655)¹ Calissano M....Latchman D.S. (2007)
16. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
17. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PubMed id 16368877)¹ Choy K.W....Pang C.P. (2006)
18. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
19. Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells. (PubMed id 15968082)¹ Weishaupt J.H....Bahr M. (2005)
20. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
21. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
22. Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina. (PubMed id 12724837)¹ de Melo J....Eisenstat D.D. (2003)
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
24. POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element. (PubMed id 9448000)¹ Budhram-Mahadeo V....Latchman D.S. (1998)
25. The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b). (PubMed id 12609742)⁹ Wagner K.D....Scholz H. (2003)
26. Elevated expression of the Brn-3a and Brn-3b transcription factors in systemic lupus erythematosus correlates with antibodies to Brn-3 and overexpression of Hsp90. (PubMed id 15818685)⁹ Ripley B.J....Latchman D.S. (2005)
27. Targeting Brn-3b in breast cancer therapy. (PubMed id 16441225)⁹ Budhram-Mahadeo V.S. and Latchman D.S. (2006)
28. Quantitative ex vivo detection of rodent retinal ganglion cells by immunolabeling Brn-3b. (PubMed id 15183108)⁹ Leahy K.M....Wax M.B. (2004)
29. Distinct responses of the herpes simplex virus and varicella zoster virus immediate early promoters to the cellular transcription factors Brn-3a and Brn-3b. (PubMed id 10224669)⁹ Brownlees J....Latchman D.S. (1999)
30. The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain. (PubMed id 7935408)⁹ Morris P.J....Latchman D.S. (1994)
31. The functionally antagonistic POU family transcription factors Brn-3a and Brn-3b show opposite changes in expression during the growth arrest and differentiation of human neuroblastoma cells. (PubMed id 8782654)⁹ Smith M.D. and Latchman D.S. (1996)
32. Differential regulation of neuronal nicotinic acetylcholine receptor subunit gene promoters by Brn-3 POU family transcription factors. (PubMed id 8713067)⁹ Milton N.G....Latchman D.S. (1996)
33. The levels of the antagonistic POU family transcription factors Brn-3a and Brn-3b in neuronal cells are regulated in opposite directions by serum growth factors. (PubMed id 7731552)⁹ Budhram-Mahadeo V....Latchman D.S. (1995)
34. The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells. (PubMed id 10597274)⁹ Budhram-Mahadeo V....Latchman D.S. (1999)
35. The HPV-activating cellular transcription factor Brn-3a is overexpressed in CIN3 cervical lesions. (PubMed id 9541499)⁹ Ndisdang D....Latchman D.S. (1998)
36. A single residue within the homeodomain of the Brn-3 POU family transcription factors determines whether they activate or repress the SNAP-25 promoter. (PubMed id 9223099)⁹ Morris P.J....Latchman D.S. (1997)
37. A single amino acid change converts an inhibitory transcription factor into an activator. (PubMed id 8662774)⁹ Dawson S.J....Latchman D.S. (1996)
38. Activation of the alpha-internexin promoter by the Brn-3a transcription factor is dependent on the N-terminal region of the protein. (PubMed id 7852360)⁹ Budhram-Mahadeo V....Latchman D.S. (1995)
39. The DNA target site for the Brn-3 POU family transcription factors can confer responsiveness to cyclic AMP and removal of serum in neuronal cells. (PubMed id 8065921)⁹ Budhram-Mahadeo V....Latchman D.S. (1994)
40. The Wilms' tumor gene Wt1 is required for normal development of the retina. (PubMed id 11889045)⁹ Wagner K.D....Scholz H. (2002)
41. POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification. (PubMed id 10357904)⁹ Gan L....Klein W.H. (1999)
42. Coordinate induction of the three neurofilament genes by the Brn-3a transcription factor. (PubMed id 9261145)⁹ Smith M.D....Latchman D.S. (1997)
43. Similarities and differences among inner retinal neurons revealed by the expression of reporter transgenes controlled by Brn-3a, Brn-3b, and Brn-3c promotor sequences. (PubMed id 8903036)⁹ Xiang M....Nathans J. (1996)
44. Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding. (PubMed id 8537352)⁹ Theil T....Moroy T. (1995)
45. The neuronal nicotinic acetylcholine receptor alpha 2 subunit gene promoter is activated by the Brn-3b POU family transcription factor and not by Brn-3a or Brn-3c. (PubMed id 7797498)⁹ Milton N.G....Latchman D.S. (1995)
46. Coupling the transcriptional regulatory action of Brn-3b to the cell cycle clock. (PubMed id 15020847)⁹ Zhu T. and Sukumar S. (2004)
47. Activation of the iNOS gene promoter by Brn-3 POU family transcription factors is dependent upon the octamer motif in the promoter. (PubMed id 9878805)⁹ Gay R.D....Latchman D.S. (1998)
48. The Brn-3c transcription factor contains a neuronal-specific activation domain. (PubMed id 9579678)⁹ Smith M.D....Latchman D.S. (1998)
49. Activation and repression of gene expression by POU family transcription factors. (PubMed id 8735273)⁹ Latchman D.S. (1996)
50. Math5 promotes retinal ganglion cell expression patterns in retinal progenitor cells. (PubMed id 17653051)⁹ Yao J....Qian J. (2007)
51. The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1. (PubMed id 15021903)⁹ Gascoyne D.M....Latchman D.S. (2004)
52. The Brn-3a transcription factor plays a key role in regulating the growth of cervical cancer cells in vivo. (PubMed id 11521202)⁹ Ndisang D....Latchman D.S. (2001)
53. Evidence that POU factor Brn-3B regulates expression of Pax-6 in neuroretina cells. (PubMed id 10526314)⁹ Plaza S....Dozier C. (1999)
54. The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. (PubMed id 8972215)⁹ Smith M.D....Latchman D.S. (1997)
55. The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements. (PubMed id 8670054)⁹ Dawson S.J....Latchman D.S. (1996)
56. Differential regulation of genes encoding synaptic proteins by members of the Brn-3 subfamily of POU transcription factors. (PubMed id 9037543)⁹ Morris P.J....Latchman D.S. (1996)
57. Activation of the herpes simplex virus immediate-early gene promoters by neuronally expressed POU family transcription factors. (PubMed id 7733899)⁹ Lillycrop K.A....Latchman D.S. (1995)

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