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Aliases for POU4F2 Gene

Aliases for POU4F2 Gene

  • POU Class 4 Homeobox 2 2 3
  • Brain-Specific Homeobox/POU Domain Protein 3B 3 4
  • Brain-3B 3 4
  • Brn-3b 3 4
  • BRN3B 3 4
  • POU Domain, Class 4, Transcription Factor 2 2
  • POU Domain Class 4, Transcription Factor 2 2
  • POU Domain Class 4 Transcription Factor 2 3
  • Brn3b POU Domain Transcription Factor 3
  • POU Domain Protein 3
  • BRN3.2 3

External Ids for POU4F2 Gene

Previous HGNC Symbols for POU4F2 Gene

  • BRN3B

Previous GeneCards Identifiers for POU4F2 Gene

  • GC04P148362
  • GC04P147935
  • GC04P148137
  • GC04P147917
  • GC04P147779
  • GC04P147560
  • GC04P143287

Summaries for POU4F2 Gene

Entrez Gene Summary for POU4F2 Gene

  • The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. [provided by RefSeq, Sep 2011]

GeneCards Summary for POU4F2 Gene

POU4F2 (POU Class 4 Homeobox 2) is a Protein Coding gene. Diseases associated with POU4F2 include wilms tumor susceptibility-5. Among its related pathways are Direct p53 effectors. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is POU6F1.

UniProtKB/Swiss-Prot for POU4F2 Gene

  • Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons

Gene Wiki entry for POU4F2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU4F2 Gene

Genomics for POU4F2 Gene

Regulatory Elements for POU4F2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POU4F2 Gene

Chromosome:
4
Start:
146,638,893 bp from pter
End:
146,642,474 bp from pter
Size:
3,582 bases
Orientation:
Plus strand

Genomic View for POU4F2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POU4F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU4F2 Gene

Proteins for POU4F2 Gene

  • Protein details for POU4F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12837-PO4F2_HUMAN
    Recommended name:
    POU domain, class 4, transcription factor 2
    Protein Accession:
    Q12837
    Secondary Accessions:
    • B1PJR6
    • B2RC84
    • Q13883
    • Q14987

    Protein attributes for POU4F2 Gene

    Size:
    409 amino acids
    Molecular mass:
    43087 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POU4F2 Gene

Proteomics data for POU4F2 Gene at MOPED

Post-translational modifications for POU4F2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU4F2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POU4F2 Gene

Domains & Families for POU4F2 Gene

Gene Families for POU4F2 Gene

Protein Domains for POU4F2 Gene

Suggested Antigen Peptide Sequences for POU4F2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12837

UniProtKB/Swiss-Prot:

PO4F2_HUMAN :
  • The polyhistidine repeat acts as a targeting signal to nuclear speckles.
  • Belongs to the POU transcription factor family. Class-4 subfamily.
Domain:
  • The polyhistidine repeat acts as a targeting signal to nuclear speckles.
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 POU-specific domain.
Family:
  • Belongs to the POU transcription factor family. Class-4 subfamily.
genes like me logo Genes that share domains with POU4F2: view

Function for POU4F2 Gene

Molecular function for POU4F2 Gene

GENATLAS Biochemistry:
POU domain,class 4,transcription factor 2,expressed in a subset of retinal ganglion cells
UniProtKB/Swiss-Prot Function:
Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons

Gene Ontology (GO) - Molecular Function for POU4F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 17637757
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 17637757
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISS --
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with POU4F2: view
genes like me logo Genes that share phenotypes with POU4F2: view

Animal Models for POU4F2 Gene

MGI Knock Outs for POU4F2:

Animal Model Products

miRNA for POU4F2 Gene

miRTarBase miRNAs that target POU4F2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POU4F2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for POU4F2 Gene

Localization for POU4F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU4F2 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POU4F2 Gene COMPARTMENTS Subcellular localization image for POU4F2 gene
Compartment Confidence
nucleus 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for POU4F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with POU4F2: view

Pathways & Interactions for POU4F2 Gene

SuperPathways for POU4F2 Gene

Superpath Contained pathways
1 Direct p53 effectors
genes like me logo Genes that share pathways with POU4F2: view

Pathways by source for POU4F2 Gene

1 BioSystems pathway for POU4F2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for POU4F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0000165 MAPK cascade IDA 21241485
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IDA 17637757
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with POU4F2: view

No data available for SIGNOR curated interactions for POU4F2 Gene

Drugs & Compounds for POU4F2 Gene

(3) Drugs for POU4F2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
estrogen Pharma 0
isoleucine Nutra 14
valine Nutra 18
genes like me logo Genes that share compounds with POU4F2: view

Transcripts for POU4F2 Gene

mRNA/cDNA for POU4F2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POU4F2 Gene

POU class 4 homeobox 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POU4F2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POU4F2 Gene

No ASD Table

Relevant External Links for POU4F2 Gene

GeneLoc Exon Structure for
POU4F2
ECgene alternative splicing isoforms for
POU4F2

Expression for POU4F2 Gene

mRNA expression in normal human tissues for POU4F2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for POU4F2 Gene

This gene is overexpressed in Testis (x32.8) and Brain - Substantia nigra (x11.0).

Protein differential expression in normal tissues from HIPED for POU4F2 Gene

This gene is overexpressed in Lavage (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POU4F2 Gene



SOURCE GeneReport for Unigene cluster for POU4F2 Gene Hs.266

mRNA Expression by UniProt/SwissProt for POU4F2 Gene

Q12837-PO4F2_HUMAN
Tissue specificity: Brain. Seems to be specific to the retina
genes like me logo Genes that share expression patterns with POU4F2: view

Protein tissue co-expression partners for POU4F2 Gene

Primer Products

In Situ Assay Products

Orthologs for POU4F2 Gene

This gene was present in the common ancestor of animals.

Orthologs for POU4F2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POU4F2 35
  • 91.18 (n)
  • 96.32 (a)
POU4F2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POU4F2 35
  • 91.58 (n)
  • 96.32 (a)
POU4F2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pou4f2 35
  • 88.59 (n)
  • 95.11 (a)
Pou4f2 16
Pou4f2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POU4F2 35
  • 97.62 (n)
  • 97.78 (a)
POU4F2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pou4f2 35
  • 89.16 (n)
  • 95.6 (a)
oppossum
(Monodelphis domestica)
Mammalia POU4F2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POU4F2 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRN3 36
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pou4f2 35
  • 78.49 (n)
  • 87.47 (a)
zebrafish
(Danio rerio)
Actinopterygii pou4f2 35
  • 77.55 (n)
  • 86.68 (a)
pou4f2 36
  • 88 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta acj6 37
  • 49 (a)
acj6 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-86 37
  • 75 (a)
unc-86 36
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToMany
Species with no ortholog for POU4F2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POU4F2 Gene

ENSEMBL:
Gene Tree for POU4F2 (if available)
TreeFam:
Gene Tree for POU4F2 (if available)

Paralogs for POU4F2 Gene

(6) SIMAP similar genes for POU4F2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POU4F2: view

Variants for POU4F2 Gene

Sequence variations from dbSNP and Humsavar for POU4F2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_059321 -

Structural Variations from Database of Genomic Variants (DGV) for POU4F2 Gene

Variant ID Type Subtype PubMed ID
nsv461675 CNV Gain 19166990
nsv830107 CNV Gain 17160897
nsv880238 CNV Loss 21882294
nsv822768 CNV Gain 20364138

Variation tolerance for POU4F2 Gene

Residual Variation Intolerance Score: 32.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POU4F2 Gene

HapMap Linkage Disequilibrium report
POU4F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU4F2 Gene

Disorders for POU4F2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for POU4F2 Gene - From: DISEASES and NovoSeek

Disorder Aliases PubMed IDs
wilms tumor susceptibility-5
  • wilms tumor
- elite association

Relevant External Links for POU4F2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POU4F2
genes like me logo Genes that share disorders with POU4F2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POU4F2 Gene

Publications for POU4F2 Gene

  1. Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells. (PMID: 17637757) Budhram-Mahadeo V.S. … Latchman D.S. (Oncogene 2008) 23 67
  2. Math5 promotes retinal ganglion cell expression patterns in retinal progenitor cells. (PMID: 17653051) Yao J. … Qian J. (Mol. Vis. 2007) 23 67
  3. Targeting Brn-3b in breast cancer therapy. (PMID: 16441225) Budhram-Mahadeo V.S. … Latchman D.S. (Expert Opin. Ther. Targets 2006) 23 67
  4. The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells. (PMID: 16152597) Samady L. … Latchman D.S. (Int. J. Cancer 2006) 23 67
  5. Elevated expression of the Brn-3a and Brn-3b transcription factors in systemic lupus erythematosus correlates with antibodies to Brn-3 and overexpression of Hsp90. (PMID: 15818685) Ripley B.J. … Latchman D.S. (Arthritis Rheum. 2005) 23 67

Products for POU4F2 Gene

Sources for POU4F2 Gene

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