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Aliases for POU4F2 Gene

Aliases for POU4F2 Gene

  • POU Class 4 Homeobox 2 2 3 5
  • Brain-Specific Homeobox/POU Domain Protein 3B 3 4
  • POU Domain, Class 4, Transcription Factor 2 2 3
  • Brain-3B 3 4
  • Brn-3b 3 4
  • BRN3B 3 4
  • POU Domain Class 4, Transcription Factor 2 2
  • Brn3b POU Domain Transcription Factor 3
  • POU Domain Protein 3
  • BRN3.2 3

External Ids for POU4F2 Gene

Previous HGNC Symbols for POU4F2 Gene

  • BRN3B

Previous GeneCards Identifiers for POU4F2 Gene

  • GC04P148362
  • GC04P147935
  • GC04P148137
  • GC04P147917
  • GC04P147779
  • GC04P147560
  • GC04P143287

Summaries for POU4F2 Gene

Entrez Gene Summary for POU4F2 Gene

  • The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. [provided by RefSeq, Sep 2011]

GeneCards Summary for POU4F2 Gene

POU4F2 (POU Class 4 Homeobox 2) is a Protein Coding gene. Diseases associated with POU4F2 include Differentiating Neuroblastoma and Wilms Tumor Susceptibility-5. Among its related pathways are Regulation of TP53 Activity and Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is POU4F1.

UniProtKB/Swiss-Prot for POU4F2 Gene

  • DNA-binding transcriptional regulator and coregulator that recognizes and binds to the consensus octamer binding site 5-AT[A/T]A[T/A]T[A/T]A-3 in promoter of target genes (PubMed:19266028, PubMed:23805044). Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor ISL1 to achieve RGC fate specification in the developing retina. Plays also a role in RGC axon formation and guidance by regulating gene expression of specific target genes. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Binds chromatin at promoter region of target genes (By similarity).

  • Isoform 1: Acts either as a transcriptional activator or repressor (PubMed:19266028, PubMed:23805044). Negatively regulates transcriptional activity of homeobox domain transcriptional factors DLX1 and DLX2, and hence prevents DLX1- and DLX2-mediated ability to promote amacrine cells specification. Involved in the positive regulation of the transcriptional factor PAX6 expression through its binding to the neuroretina-specific enhancer in neuroretina cells. Mediates positive transcriptional regulation of heat shock protein HSPB1 expression in cardiac myocytes. Positively regulates POU4F1 expression by interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site of the POU4F1 gene promoter. Plays a role in the regulation of breast cancer cell growth by promoting transcription activation as well as repression of specific target genes. Involved in tumor breast progression and invasion (By similarity). Stimulates the promoter activity of the GTP-binding protein RIT2 gene containing the octamer binding site in retinal ganglion cells (PubMed:23805044). Plays also a role either as a transcriptional coactivator or corepressor. Transcriptional coactivator cooperating with transcription factors ISL1 and ISL2 to potentiate transcriptional activation of retinal ganglion cell (RGC) target genes. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to the octamer motif. Binds to the octamer binding site to form a ternary complex with ISL1 in promoter of target genes (By similarity).

  • Isoform 2: Acts either as a transcriptional activator or repressor (PubMed:23805044). Stimulates the promoter activity of the neuronal nicotinic acetylcholine receptor alpha CHRNA2. Negatively regulates the apoptosis regulator BAX promoter activity. Inhibits promoter activity of the neuronal intermediate filament protein alpha-internexin INA gene. Plays a role in the regulation of breast cancer cell growth by promoting transcription activation as well as repression of specific target genes. Involved in tumor breast progression and invasion (By similarity). Inhibits the promoter activity of the GTP-binding protein RIT2 gene containing the octamer binding site in retinal ganglion cells (PubMed:23805044). Plays also a role either as transcriptional coactivator or corepressor. Transcriptional coactivator cooperating with transcription factors TP53 to potentiate transcriptional activation of BAX promoter activity, and hence increases neuronal cell apoptosis. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to the octamer motif. Acts also as a transcriptional coactivator via its interaction with the transcription factor ESR1 (By similarity).

Gene Wiki entry for POU4F2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU4F2 Gene

Genomics for POU4F2 Gene

Regulatory Elements for POU4F2 Gene

Enhancers for POU4F2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G146328 1.1 FANTOM5 Ensembl ENCODE 9.8 -309.2 -309192 3.0 ZNF133 JUN EP300 JUND ZNF316 FOS MAFK NFE2L2 ENSG00000251010 POU4F2 LOC105377472 GC04P146380
GH04G146333 1 Ensembl ENCODE 10.1 -305.0 -305004 1.0 HDGF PKNOX1 EED ZSCAN5C ETV6 RELB PRDM10 IKZF2 TCF7L2 MTA2 ENSG00000251010 POU4F2 LOC105377472 GC04P146380
GH04G146269 0.8 FANTOM5 9.3 -369.4 -369385 0.2 TBL1XR1 ASH2L ARID3A EED RELB IKZF2 CREM SRF MTA2 NR2F1 ENSG00000251010 LOC345051 POU4F2 ZNF827 LSM6 LOC105377472
GH04G146974 0.7 ENCODE 9.9 +336.4 336357 0.9 TAL1 CEBPB ZBTB8A OSR2 PRDM6 GATA3 ZNF610 SMARCA4 GATA2 POLR2A TTC29 POU4F2 GC04M146965 ENSG00000260090
GH04G146586 0.5 Ensembl 0.2 -52.8 -52793 0.2 CEBPA CEBPB CEBPG FOXP2 EP300 RNU1-44P POU4F2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POU4F2 on UCSC Golden Path with GeneCards custom track

Genomic Location for POU4F2 Gene

Chromosome:
4
Start:
146,638,893 bp from pter
End:
146,642,474 bp from pter
Size:
3,582 bases
Orientation:
Plus strand

Genomic View for POU4F2 Gene

Genes around POU4F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POU4F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POU4F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU4F2 Gene

Proteins for POU4F2 Gene

  • Protein details for POU4F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12837-PO4F2_HUMAN
    Recommended name:
    POU domain, class 4, transcription factor 2
    Protein Accession:
    Q12837
    Secondary Accessions:
    • B1PJR6
    • B2RC84
    • Q13883
    • Q14987

    Protein attributes for POU4F2 Gene

    Size:
    409 amino acids
    Molecular mass:
    43087 Da
    Quaternary structure:
    • Isoform 1: Interacts with DLX1 (via homeobox DNA-binding domain); this interaction suppresses DLX1-mediated transcriptional activity in postnatal retina and enhances retinal ganglion cell (RGC) differentiation. Isoform 1: Interacts with DLX2 (via homeobox DNA-binding domain); this interaction enhances RGC differentiation. Isoform 1: Interacts (via C-terminus) with ISL1 (via C-terminus). Isoform 1: Interacts with ISL2. Isoform 1 interacts with LHX2. Isoform 2: Interacts (via C-terminus) with TP53 (via C-terminus). Isoform 2: Interacts with POU4F1 isoform 1; this interaction inhibits both POU4F1 DNA-binding and transcriptional activities. Isoform 2: Interacts (C-terminus) with ESR1 (via DNA-binding domain); this interaction increases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol-independent manner.

    Alternative splice isoforms for POU4F2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POU4F2 Gene

Post-translational modifications for POU4F2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU4F2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POU4F2 Gene

Domains & Families for POU4F2 Gene

Gene Families for POU4F2 Gene

Protein Domains for POU4F2 Gene

Suggested Antigen Peptide Sequences for POU4F2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12837

UniProtKB/Swiss-Prot:

PO4F2_HUMAN :
  • The transcriptional activation domain within the N-terminal region is sufficient to induce transcriptional activity. The transcriptional repression domain containing the POU-specific domain and POU homeodomain is necessary for DNA-binding activity and also sufficient to induce transcriptional repression in a DNA-binding independent manner (By similarity). The polyhistidine repeat acts as a targeting signal to nuclear speckles (PubMed:19266028).
  • Belongs to the POU transcription factor family. Class-4 subfamily.
Domain:
  • The transcriptional activation domain within the N-terminal region is sufficient to induce transcriptional activity. The transcriptional repression domain containing the POU-specific domain and POU homeodomain is necessary for DNA-binding activity and also sufficient to induce transcriptional repression in a DNA-binding independent manner (By similarity). The polyhistidine repeat acts as a targeting signal to nuclear speckles (PubMed:19266028).
Family:
  • Belongs to the POU transcription factor family. Class-4 subfamily.
genes like me logo Genes that share domains with POU4F2: view

Function for POU4F2 Gene

Molecular function for POU4F2 Gene

GENATLAS Biochemistry:
POU domain,class 4,transcription factor 2,expressed in a subset of retinal ganglion cells
UniProtKB/Swiss-Prot Function:
DNA-binding transcriptional regulator and coregulator that recognizes and binds to the consensus octamer binding site 5-AT[A/T]A[T/A]T[A/T]A-3 in promoter of target genes (PubMed:19266028, PubMed:23805044). Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor ISL1 to achieve RGC fate specification in the developing retina. Plays also a role in RGC axon formation and guidance by regulating gene expression of specific target genes. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Binds chromatin at promoter region of target genes (By similarity).
UniProtKB/Swiss-Prot Function:
Isoform 1: Acts either as a transcriptional activator or repressor (PubMed:19266028, PubMed:23805044). Negatively regulates transcriptional activity of homeobox domain transcriptional factors DLX1 and DLX2, and hence prevents DLX1- and DLX2-mediated ability to promote amacrine cells specification. Involved in the positive regulation of the transcriptional factor PAX6 expression through its binding to the neuroretina-specific enhancer in neuroretina cells. Mediates positive transcriptional regulation of heat shock protein HSPB1 expression in cardiac myocytes. Positively regulates POU4F1 expression by interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site of the POU4F1 gene promoter. Plays a role in the regulation of breast cancer cell growth by promoting transcription activation as well as repression of specific target genes. Involved in tumor breast progression and invasion (By similarity). Stimulates the promoter activity of the GTP-binding protein RIT2 gene containing the octamer binding site in retinal ganglion cells (PubMed:23805044). Plays also a role either as a transcriptional coactivator or corepressor. Transcriptional coactivator cooperating with transcription factors ISL1 and ISL2 to potentiate transcriptional activation of retinal ganglion cell (RGC) target genes. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to the octamer motif. Binds to the octamer binding site to form a ternary complex with ISL1 in promoter of target genes (By similarity).
UniProtKB/Swiss-Prot Function:
Isoform 2: Acts either as a transcriptional activator or repressor (PubMed:23805044). Stimulates the promoter activity of the neuronal nicotinic acetylcholine receptor alpha CHRNA2. Negatively regulates the apoptosis regulator BAX promoter activity. Inhibits promoter activity of the neuronal intermediate filament protein alpha-internexin INA gene. Plays a role in the regulation of breast cancer cell growth by promoting transcription activation as well as repression of specific target genes. Involved in tumor breast progression and invasion (By similarity). Inhibits the promoter activity of the GTP-binding protein RIT2 gene containing the octamer binding site in retinal ganglion cells (PubMed:23805044). Plays also a role either as transcriptional coactivator or corepressor. Transcriptional coactivator cooperating with transcription factors TP53 to potentiate transcriptional activation of BAX promoter activity, and hence increases neuronal cell apoptosis. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to the octamer motif. Acts also as a transcriptional coactivator via its interaction with the transcription factor ESR1 (By similarity).

Gene Ontology (GO) - Molecular Function for POU4F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 17637757
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA 23805044
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 17637757
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISS,IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with POU4F2: view
genes like me logo Genes that share phenotypes with POU4F2: view

Animal Models for POU4F2 Gene

MGI Knock Outs for POU4F2:

Animal Model Products

miRNA for POU4F2 Gene

miRTarBase miRNAs that target POU4F2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POU4F2 Gene

Localization for POU4F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU4F2 Gene

Nucleus. Nucleus speckle. Cytoplasm. Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POU4F2 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for POU4F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS,IEA --
GO:0005886 plasma membrane IEA --
GO:0016607 nuclear speck IEA,IDA 19266028
genes like me logo Genes that share ontologies with POU4F2: view

Pathways & Interactions for POU4F2 Gene

genes like me logo Genes that share pathways with POU4F2: view

Gene Ontology (GO) - Biological Process for POU4F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0000165 MAPK cascade IDA 21241485
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with POU4F2: view

No data available for SIGNOR curated interactions for POU4F2 Gene

Drugs & Compounds for POU4F2 Gene

(3) Drugs for POU4F2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with POU4F2: view

Transcripts for POU4F2 Gene

mRNA/cDNA for POU4F2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POU4F2 Gene

POU class 4 homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POU4F2 Gene

No ASD Table

Relevant External Links for POU4F2 Gene

GeneLoc Exon Structure for
POU4F2
ECgene alternative splicing isoforms for
POU4F2

Expression for POU4F2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POU4F2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for POU4F2 Gene

This gene is overexpressed in Testis (x32.8) and Brain - Substantia nigra (x11.0).

Protein differential expression in normal tissues from HIPED for POU4F2 Gene

This gene is overexpressed in Lavage (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POU4F2 Gene



Protein tissue co-expression partners for POU4F2 Gene

NURSA nuclear receptor signaling pathways regulating expression of POU4F2 Gene:

POU4F2

SOURCE GeneReport for Unigene cluster for POU4F2 Gene:

Hs.266

mRNA Expression by UniProt/SwissProt for POU4F2 Gene:

Q12837-PO4F2_HUMAN
Tissue specificity: Expressed in the ganglion cell layer of the retina (PubMed:7691107). Expressed in breast cancer cell lines (at protein level) (PubMed:11526481). Expressed in the brain (PubMed:7691107). Expressed in breast cancer cell lines (PubMed:11526481).

Evidence on tissue expression from TISSUES for POU4F2 Gene

  • Eye(4.5)
genes like me logo Genes that share expression patterns with POU4F2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for POU4F2 Gene

Orthologs for POU4F2 Gene

This gene was present in the common ancestor of animals.

Orthologs for POU4F2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POU4F2 34 35
  • 97.62 (n)
oppossum
(Monodelphis domestica)
Mammalia POU4F2 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POU4F2 34 35
  • 91.58 (n)
cow
(Bos Taurus)
Mammalia POU4F2 34 35
  • 91.18 (n)
rat
(Rattus norvegicus)
Mammalia Pou4f2 34
  • 89.16 (n)
mouse
(Mus musculus)
Mammalia Pou4f2 34 16 35
  • 88.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia POU4F2 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRN3 35
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pou4f2 34
  • 78.49 (n)
zebrafish
(Danio rerio)
Actinopterygii pou4f2 34 35
  • 77.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta acj6 36 35
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-86 36 35
  • 75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToMany
Species where no ortholog for POU4F2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POU4F2 Gene

ENSEMBL:
Gene Tree for POU4F2 (if available)
TreeFam:
Gene Tree for POU4F2 (if available)

Paralogs for POU4F2 Gene

(6) SIMAP similar genes for POU4F2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POU4F2: view

Variants for POU4F2 Gene

Sequence variations from dbSNP and Humsavar for POU4F2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000148561 -- 146,637,218(+) TTCCG(A/G)GAGCT upstream-variant-2KB
rs1000249553 -- 146,641,278(+) TGTGA(C/T)AGAGA utr-variant-3-prime
rs1000567213 -- 146,637,645(+) GAAAA(A/G)TGGTC upstream-variant-2KB
rs1000821601 -- 146,639,666(+) CTCCT(C/T)CTCCT intron-variant
rs1000985954 -- 146,642,673(+) CACAG(A/G)ATACT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for POU4F2 Gene

Variant ID Type Subtype PubMed ID
esv3894049 CNV gain 25118596
nsv461675 CNV gain 19166990
nsv595651 CNV gain 21841781
nsv822768 CNV gain 20364138
nsv830107 CNV gain 17160897

Variation tolerance for POU4F2 Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POU4F2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POU4F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU4F2 Gene

Disorders for POU4F2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for POU4F2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
differentiating neuroblastoma
wilms tumor susceptibility-5
  • wilms tumor
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POU4F2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POU4F2
genes like me logo Genes that share disorders with POU4F2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POU4F2 Gene

Publications for POU4F2 Gene

  1. The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells. (PMID: 11526481) Dennis J.H. … Latchman D.S. (Oncogene 2001) 3 4 22 64
  2. The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain. (PMID: 8332509) Ring C.J.A. … Latchman D.S. (Nucleic Acids Res. 1993) 2 3 4 64
  3. Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. (PMID: 7691107) Xiang M. … Nathans J. (Neuron 1993) 3 4 22 64
  4. RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors. (PMID: 23805044) Zhang L. … Esumi N. (Mol. Vis. 2013) 3 4 64
  5. Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment. (PMID: 19266028) Salichs E. … de la Luna S. (PLoS Genet. 2009) 3 4 64

Products for POU4F2 Gene

Sources for POU4F2 Gene

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