Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

POU4F2 Gene

protein-coding GIFtS: 53
GCID: GC04P147560

POU Class 4 Homeobox 2

(Previous names: POU domain, class 4, transcription factor 2, POU domain...)
(Previous symbol: BRN3B)

14 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
POU Class 4 Homeobox 2¹ ²		brain-3B²
BRN3B¹ ² ³ ⁵		Brn3b POU Domain Transcription Factor²
POU Domain, Class 4, Transcription Factor 2¹ ²		POU Domain Class 4 Transcription Factor 2²
Brain-Specific Homeobox/POU Domain Protein 3B² ³		POU Domain Protein²
POU Domain Class 4, Transcription Factor 2¹		Brain-3B³
BRN3.2²		Brn-3B³
Brn-3b²

External Ids:	HGNC: 9219¹	Entrez Gene: 5458²	Ensembl: ENSG00000151615⁷	OMIM: 113725⁵	UniProtKB: Q12837³

Export aliases for POU4F2 gene to outside databases

Previous GC identifers: GC04P148362 GC04P147935 GC04P148137 GC04P147917 GC04P147779 GC04P143287

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POU4F2 Gene:

The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in

maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority

of breast cancers, resulting in accelerated tumor growth. (provided by RefSeq, Sep 2011)

GeneCards Summary for POU4F2 Gene:

POU4F2 (POU class 4 homeobox 2) is a protein-coding gene. Diseases associated with POU4F2 include chordoid glioma, and differentiating neuroblastoma. GO annotations related to this gene include chromatin binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO4F2_HUMAN, Q12837

Function: Transcription factor. May play a role in determining or maintaining the identities of a small subset of

visual system neurons

Gene Wiki entry for POU4F2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.2 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the POU4F2 gene promoter:
CRE-BP1 SRY Ik-2 p53 ATF-2 NRSF form 1 NRSF form 2 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POU4F2 promoter sequence

Search SABiosciences Chromatin IP Primers for POU4F2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU4F2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.2 Ensembl cytogenetic band: 4q31.22 HGNC cytogenetic band: 4q31.22

POU4F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU4F2 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P147560: view genomic region (about GC identifiers)

Start:	147,560,045 bp from pter	End:	147,563,626 bp from pter
Size:	3,582 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PO4F2_HUMAN, Q12837 (See protein sequence)

Recommended Name: POU domain, class 4, transcription factor 2

Size: 409 amino acids; 43087 Da

Subcellular location: Nucleus speckle

Secondary accessions: B1PJR6 B2RC84 Q13883 Q14987

Explore the universe of human proteins at neXtProt for POU4F2: NX_Q12837

Explore proteomics data for POU4F2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q12837

POU4F2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_004566.2

ENSEMBL proteins:

ENSP00000281321

Human Recombinant Protein Products for POU4F2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for POU4F2 OriGene Custom MassSpec OriGene Custom Protein Services for POU4F2
	GenScript Custom Purified and Recombinant Proteins Services for POU4F2
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for POU4F2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0016607	nuclear speck	IEA	--

POU4F2 for ontologies About GeneDecksing

POU4F2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for POU4F2
	GenScript Custom Superior Antibodies Services for POU4F2
	Abcam antibodies for POU4F2
	Cloud-Clone Corp. Antibodies for POU4F2
	Search ThermoFisher Antibodies for POU4F2
	LSBio Antibodies in human, mouse, rat for POU4F2

Assay Products for POU4F2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for POU4F2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for POU4F2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for POU4F2 Cloud-Clone Corp. CLIAs for POU4F2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

POU: Homeoboxes / POU class

5/6 InterPro protein domains (see all 6):

IPR010982 Lambda_DNA-bd_dom

IPR013847 POU

IPR000327 POU_specific

IPR017970 Homeobox_CS

IPR001356 Homeodomain

Graphical View of Domain Structure for InterPro Entry Q12837

ProtoNet protein and cluster: Q12837

2 Blocks protein domains:

IPB000327 POU domain

IPB013847 POU

UniProtKB/Swiss-Prot: PO4F2_HUMAN, Q12837

Domain: The polyhistidine repeat acts as a targeting signal to nuclear speckles (PubMed:19266028)

Similarity: Belongs to the POU transcription factor family. Class-4 subfamily

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 1 POU-specific domain

POU4F2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PO4F2_HUMAN, Q12837

Function: Transcription factor. May play a role in determining or maintaining the identities of a small subset of

visual system neurons

Genatlas biochemistry entry for POU4F2:

POU domain,class 4,transcription factor 2,expressed in a subset of retinal ganglion cells

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	IDA	--
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IDA	--
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	ISS	--
GO:0003677	DNA binding	--	--
GO:0003682	chromatin binding	IEA	--

POU4F2 for ontologies About GeneDecksing

Phenotypes:
6 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Pou4f2):

behavior/neurological	cellular	hearing/vestibular/ear	nervous system	normal
vision/eye

POU4F2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for POU4F2: Pou4f2^tm1Nat Pou4f2^tm1Rsd

inGenious Targeting Laboratory - Custom generated mouse model solutions for POU4F2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POU4F2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU4F2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU4F2

miRNA Products:		miRTarBase miRNAs that target POU4F2: hsa-mir-214 (MIRT005551), hsa-mir-23a (MIRT003856)

		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU4F2
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate POU4F2 (see all 34):
		hsa-miR-411* hsa-miR-323-3p hsa-miR-379* hsa-miR-30d hsa-miR-138-2* hsa-miR-374c hsa-miR-30a hsa-miR-186

		SwitchGear 3'UTR luciferase reporter plasmid: POU4F2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for POU4F2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU4F2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for POU4F2
			Sirion Biotech Customized adenovirus for overexpression of POU4F2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for POU4F2 (see all 6) OriGene ORF clones in mouse, rat for POU4F2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: POU4F2 (NM_004575)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU4F2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU4F2
		Sirion Biotech Customized lentivirus for stable overexpression of POU4F2 Customized lentivirus expression plasmids for stable overexpression of POU4F2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for POU4F2
		Search LifeMap BioReagents cell lines for POU4F2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU4F2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for POU4F2 About

See pathways by source

SuperPath

Contained pathways About

Direct p53 effectors

Direct p53 effectors

1 BioSystems Pathway for POU4F2

Direct p53 effectors

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for POU4F2

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

5 Interacting proteins for POU4F2 (Q12837³ ENSP00000281321⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ESR1	P03372³, ENSP00000206249⁴	I2D: score=5 STRING: ENSP00000206249
ALX4	Q9H161³	I2D: score=1
MIXL1	Q9H2W2³	I2D: score=1
POU6F1	Q14863³	I2D: score=1
BAX	ENSP00000293288⁴	STRING: ENSP00000293288

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	ISS	--
GO:0000165	MAPK cascade	IDA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0007409	axonogenesis	--	--
GO:0007411	axon guidance	ISS	--

POU4F2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

POU4F2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POU4F2 (PO4F2)

3 Novoseek inferred chemical compound relationships for POU4F2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
isoleucine	34.6	3	8662774 (1), 9223099 (1)
valine	26.8	3	8662774 (1), 9223099 (1)
estrogen	0	1	15833836 (1)

Search CenterWatch for drugs/clinical trials and news about POU4F2 / PO4F2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for POU4F2 gene:

NM_004575.2

Unigene Cluster for POU4F2:

POU class 4 homeobox 2

Hs.266 [show with all ESTs]

Unigene Representative Sequence: NM_004575

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000281321(uc003ikv.3)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU4F2
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate POU4F2 (see all 34):
		hsa-miR-411* hsa-miR-323-3p hsa-miR-379* hsa-miR-30d hsa-miR-138-2* hsa-miR-374c hsa-miR-30a hsa-miR-186

		SwitchGear 3'UTR luciferase reporter plasmid: POU4F2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for POU4F2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU4F2

Clone Products:		OriGene clones in human, mouse for POU4F2 (see all 6) OriGene ORF clones in mouse, rat for POU4F2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: POU4F2 (NM_004575)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU4F2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU4F2
		Sirion Biotech Customized lentivirus for stable overexpression of POU4F2 Customized lentivirus expression plasmids for stable overexpression of POU4F2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for POU4F2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat POU4F2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU4F2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU4F2

Additional mRNA sequence:

AK314982.1 BC136344.1 BC136345.1 EU439706.1 L20434.1 U06233.1 X71488.1

1 DOTS entry:

DT.404512

7 AceView cDNA sequences:

BM728968 L20434 X71488 NM_004575 BU736562 AL045162 U06233

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

POU4F2 expression in normal human tissues (normalized intensities) POU4F2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

POU4F2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/3 selected tissues (see all 3) fully expand


Eye (Sensory Organs) fully expand to see all 3 entries
Mature Ganglion Cells Ganglion Cell Layer

Neural Tube (Nervous System)
Mesencephalon

Brain (Nervous System)
midbrain

See POU4F2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POU4F2

SOURCE GeneReport for Unigene cluster: Hs.266

UniProtKB/Swiss-Prot: PO4F2_HUMAN, Q12837

Tissue specificity: Brain. Seems to be specific to the retina

SABiosciences Expression via Pathway-Focused PCR Arrays including POU4F2:

Cell Lineage Identification in human mouse rat

Terminal Differentiation Markers in human mouse rat

Stem Cell Transcription Factors in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for POU4F2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat POU4F2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU4F2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU4F2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU4F2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for POU4F2 gene from 5/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pou4f2^{1 , 5}	POU domain, class 4, transcription factor 2^{1, 5}	90.55(n)¹ 98.04(a)¹		8 (36.99 cM)⁵ 18997¹ NM_138944.2¹ NP_620394.2¹ 78433009⁵
chicken (Gallus gallus)	Aves	BRN3⁶	Brain-specific homeobox/POU domain protein 3	72(a)	possible ortholog	4(11065971-11071035)
zebrafish (Danio rerio)	Actinopterygii	pou4f2¹	POU domain, class 4, transcription factor 2	79.18(n) 88.98(a)		402816 NM_212807.1 NP_997972.1
fruit fly (Drosophila melanogaster)	Insecta	acj6³	synaptic target recognition RNA polymerase II more	49(a)		--
worm (Caenorhabditis elegans)	Secernentea	unc-86³	Pou homeodomain	75(a)		III(8284820-8288362) --

ENSEMBL Gene Tree for POU4F2 (if available)
TreeFam Gene Tree for POU4F2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for POU4F2 gene

POU5F2² POU6F2² POU2F3² POU3F1² POU3F4² POU1F1² POU3F3² POU4F3²

POU3F2² POU2F2² POU5F1B² POU4F1² POU2F1² POU6F1² POU5F1²

6 SIMAP similar genes for POU4F2 using alignment to 1 protein entry: PO4F2_HUMAN:

POU4F3 POU6F1 POU5F1P4 POU4F1 POU1F1 POU3F1

POU4F2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6537428^1,2	C	--	147558072(+)	`TCCCTG/ACCCCA`	1	--	us2k¹		12		NA WA CSA EA	378
rs140944046^1,2	C	--	147558090(+)	`GTTTCG/TCTGAG`	1	--	us2k¹		0	--	--	--	--
rs144600994^1,2		--	147558098(+)	`GAGCTC/TACACC`	1	--	us2k¹		0	--	--	--	--
rs188493620^1,2		--	147558158(+)	`CTCCAC/TACAGG`	1	--	us2k¹		0	--	--	--	--
rs1910595^1,2	C,F	--	147558237(-)	`AGCGCG/TCGACG`	1	--	us2k¹		6		NA WA EA	364
rs76832102^1,2	C,F	--	147558243(+)	`GCGCTC/TGTTGC`	1	--	us2k¹		2		NA EA	240
rs115134269^1,2	F	--	147558244(+)	`CGCTCG/TTTGCT`	1	--	us2k¹		1		WA	118
rs192471792^1,2		--	147558553(+)	`TTCCTA/GCGTCG`	1	--	us2k¹		0	--	--	--	--
rs185085567^1,2		--	147558563(+)	`GGGGTC/TCCGGG`	1	--	us2k¹		0	--	--	--	--
rs3762842^1,2	C,F,A	--	147558564(-)	`CCCCGG/CGACCC`	1	--	us2k¹		4		NA WA EA	242

HapMap Linkage Disequilibrium report for POU4F2 (147560045 - 147563626 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for POU4F2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv880238	CNV	Loss	21882294
nsv822768	CNV	Gain	20364138
nsv830107	CNV	Gain	17160897
nsv461675	CNV	Gain	19166990

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POU4F2

DNA2.0 Custom Variant and Variant Library Synthesis for POU4F2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 113725 OMIM disorders: --

14 diseases for POU4F2: About MalaCards

chordoid glioma differentiating neuroblastoma herpes simplex wilms tumor

breast cancer neuroblastoma papilloma systemic lupus erythematosus

glaucoma neuronitis cervical cancer lupus erythematosus

retinitis cervicitis

POU4F2 for disorders About GeneDecksing

6 Novoseek inferred disease relationships for POU4F2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
latent infection	42.1	1	10224669 (1)
wilms tumor	33.3	1	12609742 (1)
papilloma	29.3	2	9541499 (1)
herpes simplex	23.6	1	10224669 (1)
breast cancer	22.4	26	17637757 (4), 14726699 (3), 16152597 (3), 16441225 (2) (see all 6)
tumors	0	7	14970234 (1), 16152597 (1)

Export disorders for POU4F2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for POU4F2 gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with POU4F2)

Utopia: connect your pdf to the dynamic
world of online information

The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain. (PubMed id 8332509)^{1, 2, 3} Ring C.J.A. and Latchman D.S. (1993)
Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. (PubMed id 7691107)^{1, 2, 9} Xiang M.... Nathans J. (1993)
Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. (PubMed id 8234287)^{1, 2} Bhargava A.K.... Weissman S.M. (1993)
The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo. (PubMed id 14970234)^{1, 9} Irshad S....Budhram-Mahadeo V. (2004)
The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells. (PubMed id 16152597)^{1, 9} Samady L....Latchman D.S. (2006)
Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter. (PubMed id 15833836)^{1, 9} Lee S.A....Budhram-Mahadeo V.S. (2005)
Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells. (PubMed id 17637757)^{1, 9} Budhram-Mahadeo V.S....Latchman D.S. (2008)
Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor. (PubMed id 14726699)^{1, 9} Samady L....Latchman D.S. (2004)
The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells. (PubMed id 11526481)^{1, 9} Dennis J.H....Latchman D.S. (2001)
The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. (PubMed id 7623109)^{1, 9} Xiang M.... Nathans J. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5458	HGNC: 9219	AceView: POU4F2	Ensembl:ENSG00000151615	euGenes: HUgn5458
ECgene: POU4F2	H-InvDB: POU4F2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for POU4F2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for POU4F2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for POU4F2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for POU4F2 gene:
Search GeneIP for patents involving POU4F2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for POU4F2
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for POU4F2
	OriGene Custom Mass Spec		OriGene clones in human, mouse for POU4F2
	OriGene qSTAR qPCR primer pairs in human, mouse for POU4F2		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for POU4F2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for POU4F2		OriGene Custom Protein Services for POU4F2

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POU4F2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POU4F2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU4F2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU4F2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU4F2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU4F2

	GenScript Custom Purified and Recombinant Proteins Services for POU4F2		GenScript cDNA clones with any tag delivered in your preferred vector for POU4F2
	GenScript Custom Assay Services for POU4F2		GenScript Custom Superior Antibodies Services for POU4F2
	GenScript Custom overexpressing Cell Line Services for POU4F2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in POU4F2 promoter
	Search Chromatin IP Primers for POU4F2
	RT² qPCR Primer Assay in human, mouse, rat POU4F2
	GNC Network for POU4F2
	SABiosciences PCR Arrays including human, mouse, rat POU4F2

Search Tocris compounds for POU4F2 (PO4F2)

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Biologicals
	Novus Tissue Slides

	Antibodies for POU4F2
	See all of Abcam's Antibodies, Kits and Proteins for POU4F2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for POU4F2
	Antibodies for POU4F2
	ELISAs for POU4F2
	CLIAs for POU4F2

Search LifeMap BioReagents cell lines for POU4F2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU4F2

	SwitchGear 3'UTR luciferase reporter plasmids for POU4F2
	SwitchGear Promoter luciferase reporter plasmids for POU4F2

Search ThermoFisher Antibodies for POU4F2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU4F2

	inGenious Targeting Laboratory - Custom generated mouse model solutions for POU4F2
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POU4F2

Customized:

	lentivirus for stable overexpression of POU4F2
	lentivirus expression plasmids for stable overexpression of POU4F2
	adenovirus for overexpression of POU4F2

LSBio Antibodies in human, mouse, rat for POU4F2

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes POU4F2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

POU4F2 Gene

POU Class 4 Homeobox 2

Aliases
for POU4F2 gene

Summaries
for POU4F2 gene

Genomic Views
for POU4F2 gene

Proteins
for POU4F2 gene

Protein Domains /
Families
for POU4F2 gene

Function
for POU4F2 gene

Pathways & Interactions
for POU4F2 gene

Drugs & Compounds
for POU4F2 gene

Transcripts
for POU4F2 gene

Expression
for POU4F2 gene

Orthologs
for POU4F2 gene

Paralogs
for POU4F2 gene

Genomic Variants
for POU4F2 gene

Disorders / Diseases
for POU4F2 gene

Publications
for POU4F2 gene

External Searches for POU4F2 gene

Genome Databases showing POU4F2 gene

Other Databases showing POU4F2 gene

Specialized Databases showing POU4F2 gene

Intellectual Property
for POU4F2 gene

Products
for POU4F2 gene

View Random Gene

Advanced Search

Export list of displayed genes

POU4F2 Gene

POU Class 4 Homeobox 2

Aliasesfor POU4F2 gene

Summariesfor POU4F2 gene

Genomic Viewsfor POU4F2 gene

Proteinsfor POU4F2 gene

Protein Domains /Familiesfor POU4F2 gene

Functionfor POU4F2 gene

Pathways & Interactionsfor POU4F2 gene

Drugs & Compoundsfor POU4F2 gene

Transcriptsfor POU4F2 gene

Expression for POU4F2 gene

Orthologsfor POU4F2 gene

Paralogsfor POU4F2 gene

Genomic Variantsfor POU4F2 gene

Disorders / Diseasesfor POU4F2 gene

Publicationsfor POU4F2 gene

External Searches for POU4F2 gene

Genome Databases showing POU4F2 gene

Other Databases showing POU4F2 gene

Specialized Databases showing POU4F2 gene

Intellectual Propertyfor POU4F2 gene

Productsfor POU4F2 gene

View Random Gene

Aliases
for POU4F2 gene

Summaries
for POU4F2 gene

Genomic Views
for POU4F2 gene

Proteins
for POU4F2 gene

Protein Domains /
Families
for POU4F2 gene

Function
for POU4F2 gene

Pathways & Interactions
for POU4F2 gene

Drugs & Compounds
for POU4F2 gene

Transcripts
for POU4F2 gene

Expression
for POU4F2 gene

Orthologs
for POU4F2 gene

Paralogs
for POU4F2 gene

Genomic Variants
for POU4F2 gene

Disorders / Diseases
for POU4F2 gene

Publications
for POU4F2 gene

Intellectual Property
for POU4F2 gene

Products
for POU4F2 gene