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POU4F2 Gene

protein-coding GIFtS: 51
GCID: GC04P147560

POU Class 4 Homeobox 2

(Previous names: POU domain, class 4, transcription factor 2, POU domain...)
(Previous symbol: BRN3B)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
POU Class 4 Homeobox 2¹ ²		brain-3B²
BRN3B¹ ² ³ ⁵		Brn3b POU Domain Transcription Factor²
POU Domain, Class 4, Transcription Factor 2¹ ²		POU Domain Class 4 Transcription Factor 2²
Brain-Specific Homeobox/POU Domain Protein 3B² ³		POU Domain Protein²
POU Domain Class 4, Transcription Factor 2¹		Brain-3B³
BRN3.2²		Brn-3B³
Brn-3b²

External Ids:	HGNC: 9219¹	Entrez Gene: 5458²	Ensembl: ENSG00000151615⁷	OMIM: 113725⁵	UniProtKB: Q12837³

Export aliases for POU4F2 gene to outside databases

Previous GC identifers: GC04P148362 GC04P147935 GC04P148137 GC04P147917 GC04P147779 GC04P143287

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POU4F2 Gene:

The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in

maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority

of breast cancers, resulting in accelerated tumor growth. (provided by RefSeq, Sep 2011)

GeneCards Summary for POU4F2 Gene:

POU4F2 (POU class 4 homeobox 2) is a protein-coding gene. Diseases associated with POU4F2 include chordoid glioma, and differentiating neuroblastoma. GO annotations related to this gene include chromatin binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO4F2_HUMAN, Q12837

Function: Transcription factor. May play a role in determining or maintaining the identities of a small subset of

visual system neurons

Gene Wiki entry for POU4F2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000004.12 NC_018915.2 NT_016354.20

Regulatory elements:

Regulatory transcription factor binding sites in the POU4F2 gene promoter:
CRE-BP1 SRY Ik-2 p53 ATF-2 NRSF form 1 NRSF form 2 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POU4F2 promoter sequence

Search Chromatin IP Primers for POU4F2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU4F2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.2 Ensembl cytogenetic band: 4q31.22 HGNC cytogenetic band: 4q31.22

POU4F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU4F2 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P147560: view genomic region (about GC identifiers)

Start:	147,560,045 bp from pter	End:	147,563,626 bp from pter
Size:	3,582 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PO4F2_HUMAN, Q12837 (See protein sequence)

Recommended Name: POU domain, class 4, transcription factor 2

Size: 409 amino acids; 43087 Da

Secondary accessions: B1PJR6 B2RC84 Q13883 Q14987

Explore the universe of human proteins at neXtProt for POU4F2: NX_Q12837

Explore proteomics data for POU4F2 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See POU4F2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004566.2

ENSEMBL proteins:

ENSP00000281321

POU4F2 Human Recombinant Protein Products:

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POU4F2 Assay Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

POU: Homeoboxes / POU class

Selected InterPro protein domains (see all 6):

IPR010982 Lambda_DNA-bd_dom

IPR013847 POU

IPR000327 POU_specific

IPR017970 Homeobox_CS

IPR001356 Homeobox_dom

Graphical View of Domain Structure for InterPro Entry Q12837

ProtoNet protein and cluster: Q12837

2 Blocks protein domains:

IPB000327 POU domain

IPB013847 POU

UniProtKB/Swiss-Prot: PO4F2_HUMAN, Q12837

Domain: The polyhistidine repeat acts as a targeting signal to nuclear speckles (PubMed:19266028)

Similarity: Belongs to the POU transcription factor family. Class-4 subfamily

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 1 POU-specific domain

POU4F2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: PO4F2_HUMAN, Q12837

Function: Transcription factor. May play a role in determining or maintaining the identities of a small subset of

visual system neurons

Genatlas biochemistry entry for POU4F2:

POU domain,class 4,transcription factor 2,expressed in a subset of retinal ganglion cells

Gene Ontology (GO): Selected molecular function terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	IDA	--
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IDA	--
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	ISS	--
GO:0003677	DNA binding	--	--
GO:0003682	chromatin binding	IEA	--

POU4F2 for ontologies About GeneDecksing

Phenotypes:
6 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Pou4f2):

behavior/neurological	cellular	hearing/vestibular/ear	nervous system	normal
vision/eye

POU4F2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for POU4F2: Pou4f2^tm1Nat Pou4f2^tm1Rsd

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POU4F2

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for POU4F2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU4F2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU4F2

miRNA Products:		miRTarBase miRNAs that target POU4F2: hsa-mir-214-3p (MIRT005551), hsa-mir-23a-3p (MIRT003856)

		Block miRNA regulation of human, mouse, rat POU4F2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate POU4F2 (see all 34):
		hsa-miR-411* hsa-miR-323-3p hsa-miR-379* hsa-miR-30d hsa-miR-138-2* hsa-miR-374c hsa-miR-30a hsa-miR-186

		SwitchGear 3'UTR luciferase reporter plasmid: POU4F2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for POU4F2
		Predesigned siRNA for gene silencing in human, mouse, rat POU4F2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for POU4F2

Clone Products:		OriGene clones in human, mouse for POU4F2 (see all 5) OriGene ORF clones in mouse, rat for POU4F2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: POU4F2 (NM_004575)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for POU4F2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU4F2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

PO4F2_HUMAN, Q12837: Nucleus speckle

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytoskeleton	1

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0016607	nuclear speck	IEA	--

POU4F2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for POU4F2 About

See pathways by source

SuperPath

Contained pathways About

Direct p53 effectors

Direct p53 effectors

1 BioSystems Pathway for POU4F2

Direct p53 effectors

Pathway & Disease-focused RT² Profiler PCR Arrays including POU4F2:

Cell Lineage Identification in human mouse rat

Terminal Differentiation Markers in human mouse rat

Stem Cell Transcription Factors in human mouse rat

Interactions:

GeneGlobe Interaction Network for POU4F2

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

Selected Interacting proteins for POU4F2 (Q12837³ ENSP00000281321⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ESR1	P03372³, ENSP00000206249⁴	I2D: score=5 STRING: ENSP00000206249
POU6F1	Q14863³, ENSP00000330190⁴	I2D: score=1 STRING: ENSP00000330190
ALX4	Q9H161³	I2D: score=1
MIXL1	Q9H2W2³	I2D: score=1
BAX	ENSP00000293288⁴	STRING: ENSP00000293288

About this table

Gene Ontology (GO): Selected biological process terms (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	ISS	--
GO:0000165	MAPK cascade	IDA	--
GO:0006355	regulation of transcription, DNA-templated	--	--
GO:0007399	nervous system development	--	--
GO:0007409	axonogenesis	--	--

POU4F2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for POU4F2 (PO4F2)

3 Novoseek inferred chemical compound relationships for POU4F2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
isoleucine	34.6	3	8662774 (1), 9223099 (1)
valine	26.8	3	8662774 (1), 9223099 (1)
estrogen	0	1	15833836 (1)

POU4F2 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for POU4F2 gene:

NM_004575.2

Unigene Cluster for POU4F2:

POU class 4 homeobox 2

Hs.266 [show with all ESTs]

Unigene Representative Sequence: NM_004575

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000281321(uc003ikv.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat POU4F2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate POU4F2 (see all 34):
		hsa-miR-411* hsa-miR-323-3p hsa-miR-379* hsa-miR-30d hsa-miR-138-2* hsa-miR-374c hsa-miR-30a hsa-miR-186

		SwitchGear 3'UTR luciferase reporter plasmid: POU4F2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for POU4F2
		Predesigned siRNA for gene silencing in human, mouse, rat POU4F2

Clone Products:		OriGene clones in human, mouse for POU4F2 (see all 5) OriGene ORF clones in mouse, rat for POU4F2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: POU4F2 (NM_004575)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU4F2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU4F2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for POU4F2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat POU4F2
		QuantiTect SYBR Green Assays in human, mouse, rat POU4F2
		QuantiFast Probe-based Assays in human, mouse, rat POU4F2

Additional mRNA sequence:

AK314982.1 BC136344.1 BC136345.1 EU439706.1 L20434.1 U06233.1 X71488.1

1 DOTS entry:

DT.404512

7 AceView cDNA sequences:

BM728968 L20434 X71488 U06233 AL045162 BU736562 NM_004575

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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POU4F2 expression in normal human tissues (normalized intensities) POU4F2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

POU4F2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Eye (Sensory Organs) fully expand to see all 4 entries
Mature Ganglion Cells Ganglion Cell Layer
Retinal cells

Neurons
Mature Ganglion Cells Ganglion Cell Layer

NULL (Sensory Organs)
Retinal cells

Neural Tube (Nervous System)
Mesencephalon

POU4F2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

POU4F2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.266

UniProtKB/Swiss-Prot: PO4F2_HUMAN, Q12837

Tissue specificity: Brain. Seems to be specific to the retina

Pathway & Disease-focused RT² Profiler PCR Arrays including POU4F2:

Cell Lineage Identification in human mouse rat

Terminal Differentiation Markers in human mouse rat

Stem Cell Transcription Factors in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for POU4F2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat POU4F2
		QuantiTect SYBR Green Assays in human, mouse, rat POU4F2
		QuantiFast Probe-based Assays in human, mouse, rat POU4F2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU4F2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for POU4F2 gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pou4f2^{1 , 5}	POU domain, class 4, transcription factor 2^{1, 5}	88.59(n)¹ 95.11(a)¹		8 (36.99 cM)⁵ 18997¹ NM_138944.2¹ NP_620394.2¹ 78433011⁵
chicken (Gallus gallus)	Aves	BRN3⁶	Gallus gallus POU class 4 homeobox 3 (POU4F3), mRN...	72(a)	1 → many	4(11065971-11071035)
tropical clawed frog (Xenopus tropicalis)	Amphibia	pou4f2¹	POU class 4 homeobox 2	78.49(n) 87.47(a)		100498428 XM_004911134.1 XP_004911191.1
zebrafish (Danio rerio)	Actinopterygii	pou4f2¹	POU domain, class 4, transcription factor 2	77.55(n) 86.68(a)		402816 NM_212807.1 NP_997972.1
fruit fly (Drosophila melanogaster)	Insecta	acj6³	synaptic target recognition RNA polymerase II more	49(a)		--
worm (Caenorhabditis elegans)	Secernentea	unc-86³	Pou homeodomain	75(a)		III(8284820-8288362) --

ENSEMBL Gene Tree for POU4F2 (if available)
TreeFam Gene Tree for POU4F2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for POU4F2 gene

POU5F2² POU6F2² POU2F3² POU3F1² POU3F4² POU1F1² POU3F3² POU4F3²

POU3F2² POU2F2² POU5F1B² POU4F1² POU2F1² POU6F1² POU5F1²

6 SIMAP similar genes for POU4F2 using alignment to 1 protein entry: PO4F2_HUMAN:

POU4F3 POU6F1 POU5F1P4 POU4F1 POU1F1 POU3F1

POU4F2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6537428^1,2	C	--	147558072(+)	`TCCCTG/ACCCCA`	1	--	us2k¹		12		NA WA CSA EA	378
rs140944046^1,2	C	--	147558090(+)	`GTTTCG/TCTGAG`	1	--	us2k¹		0	--	--	--	--
rs144600994^1,2		--	147558098(+)	`GAGCTC/TACACC`	1	--	us2k¹		0	--	--	--	--
rs188493620^1,2		--	147558158(+)	`CTCCAC/TACAGG`	1	--	us2k¹		0	--	--	--	--
rs1910595^1,2	C,F	--	147558237(-)	`AGCGCG/TCGACG`	1	--	us2k¹		6		NA WA EA	364
rs76832102^1,2	C,F	--	147558243(+)	`GCGCTC/TGTTGC`	1	--	us2k¹		2		NA EA	240
rs115134269^1,2	F	--	147558244(+)	`CGCTCG/TTTGCT`	1	--	us2k¹		1		WA	118
rs192471792^1,2		--	147558553(+)	`TTCCTA/GCGTCG`	1	--	us2k¹		0	--	--	--	--
rs185085567^1,2		--	147558563(+)	`GGGGTC/TCCGGG`	1	--	us2k¹		0	--	--	--	--
rs3762842^1,2	C,F,A	--	147558564(-)	`CCCCGG/CGACCC`	1	--	us2k¹		4		NA WA EA	242

HapMap Linkage Disequilibrium report for POU4F2 (147560045 - 147563626 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for POU4F2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv880238	CNV	Loss	21882294
nsv822768	CNV	Gain	20364138
nsv830107	CNV	Gain	17160897
nsv461675	CNV	Gain	19166990

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing POU4F2

DNA2.0 Custom Variant and Variant Library Synthesis for POU4F2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 113725 OMIM disorders: --

14 diseases for POU4F2: About MalaCards

chordoid glioma differentiating neuroblastoma herpes simplex papilloma

wilms tumor neuroblastoma breast cancer glaucoma

systemic lupus erythematosus neuronitis cervical cancer lupus erythematosus

cervicitis retinitis

POU4F2 for disorders About GeneDecksing

6 Novoseek inferred disease relationships for POU4F2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
latent infection	42.1	1	10224669 (1)
wilms tumor	33.3	1	12609742 (1)
papilloma	29.3	2	9541499 (1)
herpes simplex	23.6	1	10224669 (1)
breast cancer	22.4	26	17637757 (4), 14726699 (3), 16152597 (3), 16441225 (2) (see all 6)
tumors	0	7	14970234 (1), 16152597 (1)

Export disorders for POU4F2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for POU4F2 gene, integrated from 10 sources (see all 58):
(articles sorted by number of sources associating them with POU4F2)

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The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain. (PubMed id 8332509)^{1, 2, 3} Ring C.J.A. and Latchman D.S. (Nucleic Acids Res. 1993)
Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. (PubMed id 7691107)^{1, 2, 9} Xiang M.... Nathans J. (Neuron 1993)
Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. (PubMed id 8234287)^{1, 2} Bhargava A.K.... Weissman S.M. (Proc. Natl. Acad. Sci. U.S.A. 1993)
The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo. (PubMed id 14970234)^{1, 9} Irshad S....Budhram-Mahadeo V. (J. Biol. Chem. 2004)
The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells. (PubMed id 16152597)^{1, 9} Samady L....Latchman D.S. (Int. J. Cancer 2006)
Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter. (PubMed id 15833836)^{1, 9} Lee S.A....Budhram-Mahadeo V.S. (Cancer Res. 2005)
Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells. (PubMed id 17637757)^{1, 9} Budhram-Mahadeo V.S....Latchman D.S. (Oncogene 2008)
Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor. (PubMed id 14726699)^{1, 9} Samady L....Latchman D.S. (amp 2004)
The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells. (PubMed id 11526481)^{1, 9} Dennis J.H....Latchman D.S. (Oncogene 2001)
The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. (PubMed id 7623109)^{1, 9} Xiang M.... Nathans J. (J. Neurosci. 1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5458	HGNC: 9219	AceView: POU4F2	Ensembl:ENSG00000151615	euGenes: HUgn5458
ECgene: POU4F2	H-InvDB: POU4F2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for POU4F2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for POU4F2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for POU4F2 gene
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