Aliases for POU4F2 Gene
Aliases for POU4F2 Gene
External Ids for POU4F2 Gene
- HGNC: 9219
- Entrez Gene: 5458
- Ensembl: ENSG00000151615
- OMIM: 113725
- UniProtKB: Q12837
Previous HGNC Symbols for POU4F2 Gene
- BRN3B
Previous GeneCards Identifiers for POU4F2 Gene
- GC04P148362
- GC04P147935
- GC04P148137
- GC04P147917
- GC04P147779
- GC04P147560
- GC04P143287
Summaries for POU4F2 Gene
-
The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. [provided by RefSeq, Sep 2011]
GeneCards Summary for POU4F2 Gene
POU4F2 (POU Class 4 Homeobox 2) is a Protein Coding gene. Diseases associated with POU4F2 include Differentiating Neuroblastoma and Wilms Tumor Susceptibility-5. Among its related pathways are Regulation of TP53 Activity and Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is POU4F1.
UniProtKB/Swiss-Prot for POU4F2 Gene
-
DNA-binding transcriptional regulator and coregulator that recognizes and binds to the consensus octamer binding site 5-AT[A/T]A[T/A]T[A/T]A-3 in promoter of target genes (PubMed:19266028, PubMed:23805044). Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor ISL1 to achieve RGC fate specification in the developing retina. Plays also a role in RGC axon formation and guidance by regulating gene expression of specific target genes. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Binds chromatin at promoter region of target genes (By similarity).
-
Isoform 1: Acts either as a transcriptional activator or repressor (PubMed:19266028, PubMed:23805044). Negatively regulates transcriptional activity of homeobox domain transcriptional factors DLX1 and DLX2, and hence prevents DLX1- and DLX2-mediated ability to promote amacrine cells specification. Involved in the positive regulation of the transcriptional factor PAX6 expression through its binding to the neuroretina-specific enhancer in neuroretina cells. Mediates positive transcriptional regulation of heat shock protein HSPB1 expression in cardiac myocytes. Positively regulates POU4F1 expression by interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site of the POU4F1 gene promoter. Plays a role in the regulation of breast cancer cell growth by promoting transcription activation as well as repression of specific target genes. Involved in tumor breast progression and invasion (By similarity). Stimulates the promoter activity of the GTP-binding protein RIT2 gene containing the octamer binding site in retinal ganglion cells (PubMed:23805044). Plays also a role either as a transcriptional coactivator or corepressor. Transcriptional coactivator cooperating with transcription factors ISL1 and ISL2 to potentiate transcriptional activation of retinal ganglion cell (RGC) target genes. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to the octamer motif. Binds to the octamer binding site to form a ternary complex with ISL1 in promoter of target genes (By similarity).
-
Isoform 2: Acts either as a transcriptional activator or repressor (PubMed:23805044). Stimulates the promoter activity of the neuronal nicotinic acetylcholine receptor alpha CHRNA2. Negatively regulates the apoptosis regulator BAX promoter activity. Inhibits promoter activity of the neuronal intermediate filament protein alpha-internexin INA gene. Plays a role in the regulation of breast cancer cell growth by promoting transcription activation as well as repression of specific target genes. Involved in tumor breast progression and invasion (By similarity). Inhibits the promoter activity of the GTP-binding protein RIT2 gene containing the octamer binding site in retinal ganglion cells (PubMed:23805044). Plays also a role either as transcriptional coactivator or corepressor. Transcriptional coactivator cooperating with transcription factors TP53 to potentiate transcriptional activation of BAX promoter activity, and hence increases neuronal cell apoptosis. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to the octamer motif. Acts also as a transcriptional coactivator via its interaction with the transcription factor ESR1 (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU4F2 Gene
Genomics for POU4F2 Gene
Regulatory Elements for POU4F2 Gene
Enhancers for POU4F2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH04G146328 | 1.1 | FANTOM5 Ensembl ENCODE | 9.8 | -309.2 | -309192 | 3.0 | ZNF133 JUN EP300 JUND ZNF316 FOS MAFK NFE2L2 | ENSG00000251010 POU4F2 LOC105377472 GC04P146380 |
| GH04G146333 | 1 | Ensembl ENCODE | 10.1 | -305.0 | -305004 | 1.0 | HDGF PKNOX1 EED ZSCAN5C ETV6 RELB PRDM10 IKZF2 TCF7L2 MTA2 | ENSG00000251010 POU4F2 LOC105377472 GC04P146380 |
| GH04G146269 | 0.8 | FANTOM5 | 9.3 | -369.4 | -369385 | 0.2 | TBL1XR1 ASH2L ARID3A EED RELB IKZF2 CREM SRF MTA2 NR2F1 | ENSG00000251010 LOC345051 POU4F2 ZNF827 LSM6 LOC105377472 |
| GH04G146974 | 0.7 | ENCODE | 9.9 | +336.4 | 336357 | 0.9 | TAL1 CEBPB ZBTB8A OSR2 PRDM6 GATA3 ZNF610 SMARCA4 GATA2 POLR2A | TTC29 POU4F2 GC04M146965 ENSG00000260090 |
| GH04G146586 | 0.5 | Ensembl | 0.2 | -52.8 | -52793 | 0.2 | CEBPA CEBPB CEBPG FOXP2 EP300 | RNU1-44P POU4F2 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around POU4F2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the POU4F2 gene promoter:
Regulatory Element Products
Genomic Location for POU4F2 Gene
- Chromosome:
- 4
- Start:
- 146,638,893 bp from pter
- End:
- 146,642,474 bp from pter
- Size:
- 3,582 bases
- Orientation:
- Plus strand
Genomic View for POU4F2 Gene
Genes around POU4F2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q31.22 by Ensembl
- 4q31.22 by Entrez Gene
- 4q31.22 by HGNC
POU4F2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POU4F2 Gene
Proteins for POU4F2 Gene
-
Protein details for POU4F2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q12837-PO4F2_HUMAN
- Recommended name:
- POU domain, class 4, transcription factor 2
- Protein Accession:
- Q12837
- B1PJR6
- B2RC84
- Q13883
- Q14987
Protein attributes for POU4F2 Gene
- Size:
- 409 amino acids
- Molecular mass:
- 43087 Da
- Quaternary structure:
-
- Isoform 1: Interacts with DLX1 (via homeobox DNA-binding domain); this interaction suppresses DLX1-mediated transcriptional activity in postnatal retina and enhances retinal ganglion cell (RGC) differentiation. Isoform 1: Interacts with DLX2 (via homeobox DNA-binding domain); this interaction enhances RGC differentiation. Isoform 1: Interacts (via C-terminus) with ISL1 (via C-terminus). Isoform 1: Interacts with ISL2. Isoform 1 interacts with LHX2. Isoform 2: Interacts (via C-terminus) with TP53 (via C-terminus). Isoform 2: Interacts with POU4F1 isoform 1; this interaction inhibits both POU4F1 DNA-binding and transcriptional activities. Isoform 2: Interacts (C-terminus) with ESR1 (via DNA-binding domain); this interaction increases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol-independent manner.
Protein Expression for POU4F2 Gene
Post-translational modifications for POU4F2 Gene
Other Protein References for POU4F2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for POU4F2
- Invitrogen Antibodies for POU4F2
- antibodies-online Antibodies for POU4F2: See all 34
- Search GeneTex for Antibodies for POU4F2
-
Santa Cruz Biotechnology (SCBT) Antibodies for POU4F2
Protein Products
-
OriGene Purified Proteins for POU4F2
- Search Origene for MassSpec and Protein Over-expression Lysates for POU4F2
- Origene Custom Protein Services for POU4F2
- Search GeneTex for Proteins for POU4F2
No data available for DME Specific Peptides for POU4F2 Gene
Domains & Families for POU4F2 Gene
Gene Families for POU4F2 Gene
Protein Domains for POU4F2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for POU4F2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q12837UniProtKB/Swiss-Prot:
PO4F2_HUMAN :- The transcriptional activation domain within the N-terminal region is sufficient to induce transcriptional activity. The transcriptional repression domain containing the POU-specific domain and POU homeodomain is necessary for DNA-binding activity and also sufficient to induce transcriptional repression in a DNA-binding independent manner (By similarity). The polyhistidine repeat acts as a targeting signal to nuclear speckles (PubMed:19266028).
- Belongs to the POU transcription factor family. Class-4 subfamily.
- Domain:
-
- The transcriptional activation domain within the N-terminal region is sufficient to induce transcriptional activity. The transcriptional repression domain containing the POU-specific domain and POU homeodomain is necessary for DNA-binding activity and also sufficient to induce transcriptional repression in a DNA-binding independent manner (By similarity). The polyhistidine repeat acts as a targeting signal to nuclear speckles (PubMed:19266028).
- Family:
-
- Belongs to the POU transcription factor family. Class-4 subfamily.
Function for POU4F2 Gene
Molecular function for POU4F2 Gene
- GENATLAS Biochemistry:
- POU domain,class 4,transcription factor 2,expressed in a subset of retinal ganglion cells
- UniProtKB/Swiss-Prot Function:
- DNA-binding transcriptional regulator and coregulator that recognizes and binds to the consensus octamer binding site 5-AT[A/T]A[T/A]T[A/T]A-3 in promoter of target genes (PubMed:19266028, PubMed:23805044). Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor ISL1 to achieve RGC fate specification in the developing retina. Plays also a role in RGC axon formation and guidance by regulating gene expression of specific target genes. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Binds chromatin at promoter region of target genes (By similarity).
- UniProtKB/Swiss-Prot Function:
- Isoform 1: Acts either as a transcriptional activator or repressor (PubMed:19266028, PubMed:23805044). Negatively regulates transcriptional activity of homeobox domain transcriptional factors DLX1 and DLX2, and hence prevents DLX1- and DLX2-mediated ability to promote amacrine cells specification. Involved in the positive regulation of the transcriptional factor PAX6 expression through its binding to the neuroretina-specific enhancer in neuroretina cells. Mediates positive transcriptional regulation of heat shock protein HSPB1 expression in cardiac myocytes. Positively regulates POU4F1 expression by interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site of the POU4F1 gene promoter. Plays a role in the regulation of breast cancer cell growth by promoting transcription activation as well as repression of specific target genes. Involved in tumor breast progression and invasion (By similarity). Stimulates the promoter activity of the GTP-binding protein RIT2 gene containing the octamer binding site in retinal ganglion cells (PubMed:23805044). Plays also a role either as a transcriptional coactivator or corepressor. Transcriptional coactivator cooperating with transcription factors ISL1 and ISL2 to potentiate transcriptional activation of retinal ganglion cell (RGC) target genes. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to the octamer motif. Binds to the octamer binding site to form a ternary complex with ISL1 in promoter of target genes (By similarity).
- UniProtKB/Swiss-Prot Function:
- Isoform 2: Acts either as a transcriptional activator or repressor (PubMed:23805044). Stimulates the promoter activity of the neuronal nicotinic acetylcholine receptor alpha CHRNA2. Negatively regulates the apoptosis regulator BAX promoter activity. Inhibits promoter activity of the neuronal intermediate filament protein alpha-internexin INA gene. Plays a role in the regulation of breast cancer cell growth by promoting transcription activation as well as repression of specific target genes. Involved in tumor breast progression and invasion (By similarity). Inhibits the promoter activity of the GTP-binding protein RIT2 gene containing the octamer binding site in retinal ganglion cells (PubMed:23805044). Plays also a role either as transcriptional coactivator or corepressor. Transcriptional coactivator cooperating with transcription factors TP53 to potentiate transcriptional activation of BAX promoter activity, and hence increases neuronal cell apoptosis. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to the octamer motif. Acts also as a transcriptional coactivator via its interaction with the transcription factor ESR1 (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IDA | 17637757 |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IDA | 23805044 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | IDA | 17637757 |
| GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | ISS,IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for POU4F2 Gene
- MGI mutant phenotypes for POU4F2:
- inferred from 11 alleles
- GenomeRNAi human phenotypes for POU4F2:
Animal Models for POU4F2 Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for POU4F2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for POU4F2 gene
- Search ViGene Biosciences for POU4F2
CRISPR Products
-
OriGene CRISPR knockouts for POU4F2
-
Santa Cruz Biotechnology (SCBT) CRISPR for POU4F2
- GenScript: Design CRISPR guide RNA sequences for POU4F2
miRNA for POU4F2 Gene
- miRTarBase miRNAs that target POU4F2
miRNA Products
- Search ViGene Biosciences for POU4F2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for POU4F2
- Browse OriGene Inhibitory RNA Products For POU4F2
-
ViGene Biosciences ready-to-package AAV shRNAs for POU4F2 gene
Clone Products
-
OriGene ORF clones in human for POU4F2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for POU4F2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for POU4F2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for POU4F2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for POU4F2
-
ViGene Biosciences adenoviral particle packaged cDNA for POU4F2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for POU4F2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for POU4F2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POU4F2 Gene
Localization for POU4F2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for POU4F2 Gene
- Nucleus. Nucleus speckle. Cytoplasm. Cell membrane.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 3 |
| cytoskeleton | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | ISS,IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016607 | nuclear speck | IEA,IDA | 19266028 |
Pathways & Interactions for POU4F2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of TP53 Activity | ||
| 2 | Gene Expression |
.48
|
|
| 3 | Direct p53 effectors | ||
Pathways by source for POU4F2 Gene
1 BioSystems pathway for POU4F2 Gene
Interacting Proteins for POU4F2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | ISS | -- |
| GO:0000165 | MAPK cascade | IDA | 21241485 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | IEA | -- |
No data available for SIGNOR curated interactions for POU4F2 Gene
Transcripts for POU4F2 Gene
mRNA/cDNA for POU4F2 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (7) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for POU4F2
-
Santa Cruz Biotechnology (SCBT) CRISPR for POU4F2
- GenScript: Design CRISPR guide RNA sequences for POU4F2
miRNA Products
- Search ViGene Biosciences for POU4F2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for POU4F2
- Browse OriGene Inhibitory RNA Products For POU4F2
-
ViGene Biosciences ready-to-package AAV shRNAs for POU4F2 gene
Clone Products
-
OriGene ORF clones in human for POU4F2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for POU4F2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for POU4F2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for POU4F2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for POU4F2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Immature Ganglion Cells Ganglion Cell Layer
- Mature Ganglion Cells Ganglion Cell Layer
- Ganglion Precursor Cells Ganglion Cell Layer
- Retinal cells(Eiraku M et. al. 2012)
-
Neurons
- Immature Ganglion Cells Ganglion Cell Layer
- Mature Ganglion Cells Ganglion Cell Layer
- Ganglion Precursor Cells Ganglion Cell Layer
- Neural Tube (Nervous System)
- NULL (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for POU4F2 Gene
This gene is overexpressed in Testis (x32.8) and Brain - Substantia nigra (x11.0).
This gene is overexpressed in Lavage (68.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POU4F2 Gene
NURSA nuclear receptor signaling pathways regulating expression of POU4F2 Gene:
POU4F2SOURCE GeneReport for Unigene cluster for POU4F2 Gene:
Hs.266mRNA Expression by UniProt/SwissProt for POU4F2 Gene:
Q12837-PO4F2_HUMAN
Tissue specificity:
Expressed in the ganglion cell layer of the retina (PubMed:7691107). Expressed in breast cancer cell lines (at protein level) (PubMed:11526481). Expressed in the brain (PubMed:7691107). Expressed in breast cancer cell lines (PubMed:11526481).
Evidence on tissue expression from TISSUES for POU4F2 Gene
- Eye(4.5)
Primer Products
-
OriGene qPCR primer pairs for POU4F2
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for POU4F2 Gene
Orthologs for POU4F2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | POU4F2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | POU4F2 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | POU4F2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | POU4F2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pou4f2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Pou4f2 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | POU4F2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BRN3 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pou4f2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pou4f2 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | acj6 36 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | unc-86 36 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for POU4F2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for POU4F2 Gene
Paralogs for POU4F2 Gene
(6) SIMAP similar genes for POU4F2 Gene using alignment to 1 proteins:
Variants for POU4F2 Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000148561 | -- | 146,637,218(+) | TTCCG(A/G)GAGCT | upstream-variant-2KB | |
| rs1000249553 | -- | 146,641,278(+) | TGTGA(C/T)AGAGA | utr-variant-3-prime | |
| rs1000567213 | -- | 146,637,645(+) | GAAAA(A/G)TGGTC | upstream-variant-2KB | |
| rs1000821601 | -- | 146,639,666(+) | CTCCT(C/T)CTCCT | intron-variant | |
| rs1000985954 | -- | 146,642,673(+) | CACAG(A/G)ATACT | downstream-variant-500B |
Residual Variation Intolerance Score:
32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.04;
75.08% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for POU4F2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- POU4F2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU4F2 Gene
Disorders for POU4F2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| differentiating neuroblastoma |
|
|
| wilms tumor susceptibility-5 |
|
|
| breast cancer |
|
Search POU4F2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for POU4F2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- POU4F2
No data available for UniProtKB/Swiss-Prot and Genatlas for POU4F2 Gene
Publications for POU4F2 Gene
- The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells. (PMID: 11526481) Dennis J.H. … Latchman D.S. (Oncogene 2001) 3 4 22 64
- The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain. (PMID: 8332509) Ring C.J.A. … Latchman D.S. (Nucleic Acids Res. 1993) 2 3 4 64
- Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. (PMID: 7691107) Xiang M. … Nathans J. (Neuron 1993) 3 4 22 64
- RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors. (PMID: 23805044) Zhang L. … Esumi N. (Mol. Vis. 2013) 3 4 64
- Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment. (PMID: 19266028) Salichs E. … de la Luna S. (PLoS Genet. 2009) 3 4 64
Products for POU4F2 Gene
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- OriGene Purified Proteins for POU4F2
- Search Origene for MassSpec and Protein Over-expression Lysates for POU4F2
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for POU4F2
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- OriGene qPCR primer pairs for POU4F2
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For POU4F2
- GenScript: Next-day shipping cDNA ORF clone for POU4F2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for POU4F2
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- GenScript Custom overexpressing Cell Line Services for POU4F2
- GenScript: Design CRISPR guide RNA sequences for POU4F2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Human cDNA Clone for POU4F2
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- Novus Biologicals Antibodies for POU4F2
- Novus Biologicals
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- Invitrogen Antibodies for POU4F2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Search GeneTex for Antibodies for POU4F2
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- ViGene Biosciences adenoviral particle packaged cDNA for POU4F2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for POU4F2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for POU4F2 gene
- Search ViGene Biosciences for POU4F2
- Santa Cruz Biotechnology (SCBT) Antibodies for POU4F2
- Search Santa Cruz Biotechnology (SCBT) for POU4F2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for POU4F2
- Horizon Cell Lines for POU4F2
- Cyagen custom Knockout/knockin (KOKI) mouse models for POU4F2
- VectorBuilder custom plasmid, inducible vectors for POU4F2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for POU4F2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for POU4F2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
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- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
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- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer