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POU4F2 Gene

protein-coding   GIFtS: 51
GCID: GC04P147560

POU Class 4 Homeobox 2

(Previous names: POU domain, class 4, transcription factor 2, POU domain...)
(Previous symbol: BRN3B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
POU Class 4 Homeobox 21 2     brain-3B2
BRN3B1 2 3 5     Brn3b POU Domain Transcription Factor2
POU Domain, Class 4, Transcription Factor 21 2     POU Domain Class 4 Transcription Factor 22
Brain-Specific Homeobox/POU Domain Protein 3B2 3     POU Domain Protein2
POU Domain Class 4, Transcription Factor 21     Brain-3B3
BRN3.22     Brn-3B3
Brn-3b2     

External Ids:    HGNC: 92191   Entrez Gene: 54582   Ensembl: ENSG000001516157   OMIM: 1137255   UniProtKB: Q128373   

Export aliases for POU4F2 gene to outside databases

Previous GC identifers: GC04P148362 GC04P147935 GC04P148137 GC04P147917 GC04P147779 GC04P143287


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POU4F2 Gene:
The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in
maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority
of breast cancers, resulting in accelerated tumor growth. (provided by RefSeq, Sep 2011)

GeneCards Summary for POU4F2 Gene:
POU4F2 (POU class 4 homeobox 2) is a protein-coding gene. Diseases associated with POU4F2 include chordoid glioma, and differentiating neuroblastoma. GO annotations related to this gene include chromatin binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO4F2_HUMAN, Q12837
Function: Transcription factor. May play a role in determining or maintaining the identities of a small subset of
visual system neurons

Gene Wiki entry for POU4F2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the POU4F2 gene promoter:
         CRE-BP1   SRY   Ik-2   p53   ATF-2   NRSF form 1   NRSF form 2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOU4F2 promoter sequence
   Search Chromatin IP Primers for POU4F2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU4F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.2   Ensembl cytogenetic band:  4q31.22   HGNC cytogenetic band: 4q31.22

POU4F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU4F2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P147560:  view genomic region     (about GC identifiers)

Start:
147,560,045 bp from pter      End:
147,563,626 bp from pter
Size:
3,582 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PO4F2_HUMAN, Q12837 (See protein sequence)
Recommended Name: POU domain, class 4, transcription factor 2  
Size: 409 amino acids; 43087 Da
Secondary accessions: B1PJR6 B2RC84 Q13883 Q14987

Explore the universe of human proteins at neXtProt for POU4F2: NX_Q12837

Explore proteomics data for POU4F2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POU4F2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004566.2  
    ENSEMBL proteins: 
     ENSP00000281321  

    POU4F2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POU: Homeoboxes / POU class

    Selected InterPro protein domains (see all 6):
     IPR010982 Lambda_DNA-bd_dom
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry Q12837

    ProtoNet protein and cluster: Q12837

    2 Blocks protein domains:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO4F2_HUMAN, Q12837
    Domain: The polyhistidine repeat acts as a targeting signal to nuclear speckles (PubMed:19266028)
    Similarity: Belongs to the POU transcription factor family. Class-4 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    POU4F2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO4F2_HUMAN, Q12837
    Function: Transcription factor. May play a role in determining or maintaining the identities of a small subset of
    visual system neurons

         Genatlas biochemistry entry for POU4F2:
    POU domain,class 4,transcription factor 2,expressed in a subset of retinal ganglion cells

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA--
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription ISS--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
         
    POU4F2 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Pou4f2):
     behavior/neurological  cellular  hearing/vestibular/ear  nervous system  normal 
     vision/eye 

    POU4F2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for POU4F2: Pou4f2tm1Nat Pou4f2tm1Rsd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POU4F2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU4F2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU4F2

    miRNA
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    miRTarBase miRNAs that target POU4F2:
    hsa-mir-214-3p (MIRT005551), hsa-mir-23a-3p (MIRT003856)

    Block miRNA regulation of human, mouse, rat POU4F2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate POU4F2 (see all 34):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-379* hsa-miR-30d hsa-miR-138-2* hsa-miR-374c hsa-miR-30a hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidPOU4F2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for POU4F2
    Predesigned siRNA for gene silencing in human, mouse, rat POU4F2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: POU4F2 (NM_004575)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU4F2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PO4F2_HUMAN, Q12837: Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0016607nuclear speck IEA--

    POU4F2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POU4F2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Direct p53 effectors
    Direct p53 effectors


    1 BioSystems Pathway for POU4F2
        Direct p53 effectors


        Pathway & Disease-focused RT2 Profiler PCR Arrays including POU4F2: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Stem Cell Transcription Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for POU4F2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for POU4F2 (Q128373 ENSP000002813214) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR1P033723, ENSP000002062494I2D: score=5 STRING: ENSP00000206249
    POU6F1Q148633, ENSP000003301904I2D: score=1 STRING: ENSP00000330190
    ALX4Q9H1613I2D: score=1 
    MIXL1Q9H2W23I2D: score=1 
    BAXENSP000002932884STRING: ENSP00000293288
    About this table

    Gene Ontology (GO): 15 biological process terms (see first 5):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0000165MAPK cascade IDA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007399nervous system development ----
    GO:0007409axonogenesis ----
    GO:0007411axon guidance ISS--
    GO:0007605sensory perception of sound IEA--
    GO:0030182neuron differentiation ISS--
    GO:0030520intracellular estrogen receptor signaling pathway IDA--
    GO:0031290retinal ganglion cell axon guidance IEA--
    GO:0045597positive regulation of cell differentiation ISS--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA--
    GO:0048675axon extension IEA--
    GO:0050885neuromuscular process controlling balance IEA--
    GO:0060041retina development in camera-type eye ISS--

    POU4F2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POU4F2 (PO4F2)

    3 Novoseek inferred chemical compound relationships for POU4F2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    isoleucine 34.6 3 8662774 (1), 9223099 (1)
    valine 26.8 3 8662774 (1), 9223099 (1)
    estrogen 0 1 15833836 (1)



    POU4F2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for POU4F2 gene: 
    NM_004575.2  

    Unigene Cluster for POU4F2:

    POU class 4 homeobox 2
    Hs.266  [show with all ESTs]
    Unigene Representative Sequence: NM_004575
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000281321(uc003ikv.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat POU4F2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate POU4F2 (see all 34):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-379* hsa-miR-30d hsa-miR-138-2* hsa-miR-374c hsa-miR-30a hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidPOU4F2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat POU4F2
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      QuantiTect SYBR Green Assays in human, mouse, rat POU4F2
      QuantiFast Probe-based Assays in human, mouse, rat POU4F2

    Additional mRNA sequence: 

    AK314982.1 BC136344.1 BC136345.1 EU439706.1 L20434.1 U06233.1 X71488.1 

    1 DOTS entry:

    DT.404512 

    7 AceView cDNA sequences:

    BM728968 L20434 X71488 U06233 AL045162 BU736562 NM_004575 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    POU4F2 expression in normal human tissues (normalized intensities)      POU4F2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    POU4F2 Expression
    About this image


    POU4F2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Mature Ganglion Cells Ganglion Cell Layer
             Retinal cells
     
     Neurons
             Mature Ganglion Cells Ganglion Cell Layer
     
     NULL (Sensory Organs)
             Retinal cells
     
     Neural Tube (Nervous System)
             Mesencephalon
    POU4F2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POU4F2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.266

    UniProtKB/Swiss-Prot: PO4F2_HUMAN, Q12837
    Tissue specificity: Brain. Seems to be specific to the retina

        Pathway & Disease-focused RT2 Profiler PCR Arrays including POU4F2: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Stem Cell Transcription Factors in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat POU4F2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU4F2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for POU4F2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou4f21 , 5 POU domain, class 4, transcription factor 21, 5 88.59(n)1
    95.11(a)1
      8 (36.99 cM)5
    189971  NM_138944.21  NP_620394.21 
     784330115 
    chicken
    (Gallus gallus)
    Aves BRN36
    Gallus gallus POU class 4 homeobox 3 (POU4F3), mRN...
    72(a)
    1 → many
    4(11065971-11071035)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pou4f21 POU class 4 homeobox 2 78.49(n)
    87.47(a)
      100498428  XM_004911134.1  XP_004911191.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pou4f21 POU domain, class 4, transcription factor 2 77.55(n)
    86.68(a)
      402816  NM_212807.1  NP_997972.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta acj63 synaptic target recognition RNA
    polymerase II more
    49(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea unc-863 Pou homeodomain 75(a)   III(8284820-8288362)   --


    ENSEMBL Gene Tree for POU4F2 (if available)
    TreeFam Gene Tree for POU4F2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POU4F2 gene
    POU5F22  POU6F22  POU2F32  POU3F12  POU3F42  POU1F12  POU3F32  POU4F32  
    POU3F22  POU2F22  POU5F1B2  POU4F12  POU2F12  POU6F12  POU5F12  
    6 SIMAP similar genes for POU4F2 using alignment to 1 protein entry:     PO4F2_HUMAN:
    POU4F3    POU6F1    POU5F1P4    POU4F1    POU1F1    POU3F1

    POU4F2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POU4F2 (see all 182)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs65374281,2
    C--147558072(+) TCCCTG/ACCCCA 1 -- us2k112Minor allele frequency- A:0.00NA WA CSA EA 378
    rs1409440461,2
    C--147558090(+) GTTTCG/TCTGAG 1 -- us2k10--------
    rs1446009941,2
    --147558098(+) GAGCTC/TACACC 1 -- us2k10--------
    rs1884936201,2
    --147558158(+) CTCCAC/TACAGG 1 -- us2k10--------
    rs19105951,2
    C,F--147558237(-) AGCGCG/TCGACG 1 -- us2k16Minor allele frequency- T:0.08NA WA EA 364
    rs768321021,2
    C,F--147558243(+) GCGCTC/TGTTGC 1 -- us2k12Minor allele frequency- T:0.14NA EA 240
    rs1151342691,2
    F--147558244(+) CGCTCG/TTTGCT 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1924717921,2
    --147558553(+) TTCCTA/GCGTCG 1 -- us2k10--------
    rs1850855671,2
    --147558563(+) GGGGTC/TCCGGG 1 -- us2k10--------
    rs37628421,2
    C,F,A--147558564(-) CCCCGG/CGACCC 1 -- us2k14Minor allele frequency- C:0.15NA WA EA 242

    HapMap Linkage Disequilibrium report for POU4F2 (147560045 - 147563626 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for POU4F2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv880238CNV Loss21882294
    nsv822768CNV Gain20364138
    nsv830107CNV Gain17160897
    nsv461675CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 113725    OMIM disorders: --

    14 diseases for POU4F2:    About MalaCards
    chordoid glioma    differentiating neuroblastoma    herpes simplex    papilloma
    wilms tumor    neuroblastoma    breast cancer    glaucoma
    systemic lupus erythematosus    neuronitis    cervical cancer    lupus erythematosus
    cervicitis    retinitis


    POU4F2 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for POU4F2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    latent infection 42.1 1 10224669 (1)
    wilms tumor 33.3 1 12609742 (1)
    papilloma 29.3 2 9541499 (1)
    herpes simplex 23.6 1 10224669 (1)
    breast cancer 22.4 26 17637757 (4), 14726699 (3), 16152597 (3), 16441225 (2) (see all 6)
    tumors 0 7 14970234 (1), 16152597 (1)


    Export disorders for POU4F2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POU4F2 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with POU4F2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain. (PubMed id 8332509)1, 2, 3 Ring C.J.A. and Latchman D.S. (Nucleic Acids Res. 1993)
    2. Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. (PubMed id 7691107)1, 2, 9 Xiang M.... Nathans J. (Neuron 1993)
    3. Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. (PubMed id 8234287)1, 2 Bhargava A.K.... Weissman S.M. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    4. The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo. (PubMed id 14970234)1, 9 Irshad S....Budhram-Mahadeo V. (J. Biol. Chem. 2004)
    5. The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells. (PubMed id 16152597)1, 9 Samady L....Latchman D.S. (Int. J. Cancer 2006)
    6. Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter. (PubMed id 15833836)1, 9 Lee S.A....Budhram-Mahadeo V.S. (Cancer Res. 2005)
    7. Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells. (PubMed id 17637757)1, 9 Budhram-Mahadeo V.S....Latchman D.S. (Oncogene 2008)
    8. Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor. (PubMed id 14726699)1, 9 Samady L....Latchman D.S. (amp 2004)
    9. The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells. (PubMed id 11526481)1, 9 Dennis J.H....Latchman D.S. (Oncogene 2001)
    10. The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. (PubMed id 7623109)1, 9 Xiang M.... Nathans J. (J. Neurosci. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5458 HGNC: 9219 AceView: POU4F2 Ensembl:ENSG00000151615 euGenes: HUgn5458
    ECgene: POU4F2 H-InvDB: POU4F2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POU4F2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POU4F2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POU4F2 gene:
    Search GeneIP for patents involving POU4F2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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