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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU4F1 Gene

protein-coding   GIFtS: 59
GCID: GC13M079173

POU class 4 homeobox 1

(Previous names: POU domain class 4, transcription factor 1 )
(Previous symbol: BRN3A)
 Explore 24 diseases affiliated with
POU4F1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for POU4F1    

Aliases
for POU4F1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
POU Class 4 Homeobox 11 2     Brain-3A3
BRN3A1 2 3 5     Brn-3A3
RDC-11 2     POU Domain, Class 4, Transcription Factor 12
Brain-Specific Homeobox/POU Domain Protein 3A2 3     Brain-3A3
Homeobox/POU Domain Protein RDC-12 3     Brn-3A3
Oct-T12 3     RDC13
POU Domain Class 4, Transcription Factor 11     

External Ids:    HGNC: 92181   Entrez Gene: 54572   Ensembl: ENSG000001521927   OMIM: 6016325   UniProtKB: Q018513   

Export aliases for POU4F1 gene to outside databases

Previous GC identifers: GC13M077140 GC13M073168 GC13M078109 GC13M076971 GC13M078071 GC13M059873


Summaries
for POU4F1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for POU4F1:
This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset
of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote
the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias.
(provided by RefSeq, Mar 2012)

UniProtKB/Swiss-Prot: PO4F1_HUMAN, Q01851
Function: Probable transcription factor which may play a role in the regulation of specific gene expression within a
subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual
system neurons

Gene Wiki entry for POU4F1


Genomic Views
for POU4F1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU4F1 gene promoter:
         E2F-3a   E2F-4   E2F-5   Sp1   E2F-2   Evi-1   S8   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POU4F1 promoter sequence
   Search SABiosciences Chromatin IP Primers for POU4F1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU4F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31.1   Ensembl cytogenetic band:  13q31.1   HGNC cytogenetic band: 13q31.1

POU4F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU4F1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M079173:  view genomic region     (about GC identifiers)

Start:
 79,173,227 bp from pter      End:
 79,177,695 bp from pter
Size:
 4,469 bases      Orientation:
 minus strand

Proteins
for POU4F1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PO4F1_HUMAN, Q01851 (See protein sequence)
Recommended Name: POU domain, class 4, transcription factor 1  
Size: 419 amino acids; 42697 Da
Subcellular location: Nucleus
Developmental stage: Expression peaks early in embryogenesis (day 13.5) and is undetectable 14 days after birth
Sequence caution: Sequence=CAA45907.1; Type=Frameshift; Positions=11, 13, 33, 43, 57, 61, 74, 76, 133, 135, 138, 340,
342;
Secondary accessions: Q14986 Q15318 Q5T227

Explore the universe of human proteins at neXtProt for POU4F1: NX_Q01851

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q01851

    • POU4F1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006228.3  
    ENSEMBL proteins: 
     ENSP00000366413  

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    Novus Biologicals POU4F1 Proteins
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    Uscn Proteins for POU4F1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--
    GO:0005634nucleus ----
    GO:0043005neuron projection IEA--


    POU4F1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for POU4F1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    POU4F1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR010982 Lambda_DNA-bd_dom
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry Q01851

    ProtoNet protein and cluster: Q01851

    2 Blocks protein families:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO4F1_HUMAN, Q01851
    Similarity: Belongs to the POU transcription factor family. Class-4 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    Function
    for POU4F1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PO4F1_HUMAN, Q01851
    Function: Probable transcription factor which may play a role in the regulation of specific gene expression within a
    subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual
    system neurons

         Genatlas biochemistry entry for POU4F1:
    POU domain,class 4,transcription factor 1,mammalian homeo box backfoot,Drosophila bicoid related,expressed in Rathke
    pouch at an early stage of pituitary development and in a subset of adult anterior pituitary cells that express POMC

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    hsa-miR-520f hsa-miR-607 hsa-miR-300 hsa-miR-411 hsa-miR-138-2* hsa-miR-759 hsa-miR-642b hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmid: POU4F1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding ISS--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ISS--


    POU4F1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for POU4F1:
     Decreased G3BP1 protein expres  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for POU4F1: Pou4f1tm1Nat Pou4f1tm1Dsl Pou4f1tm1Rsd Pou4f1tm2Dsl
         5 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Pou4f1):
     behavior/neurological  embryogenesis  mortality/aging  nervous system  vision/eye 

    POU4F1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for POU4F1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Direct p53 effectors
    		Direct p53 effectors1.00


    1 BioSystems Pathway for POU4F1 
        Direct p53 effectors


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU4F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for POU4F1 (Q018513 ENSP000003664134) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIT2Q995783, ENSP000003218054I2D: score=2 STRING: ENSP00000321805
    ESR1P033723, ENSP000002062494I2D: score=5 STRING: ENSP00000206249
    EWSR1Q018443, ENSP000003810314I2D: score=1 STRING: ENSP00000381031
    BAXENSP000002932884STRING: ENSP00000293288
    BCL2ENSP000003296234STRING: ENSP00000329623
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001967suckling behavior IEA--
    GO:0003223ventricular compact myocardium morphogenesis IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007399nervous system development ----


    POU4F1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for POU4F1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POU4F1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for POU4F1
    3 Novoseek chemical compound relationships for POU4F1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    isoleucine 28.4 2 8662774 (1), 9223099 (1)
    valine 20.3 2 8662774 (1), 9223099 (1)
    nitric oxide 0 1 17702766 (1)

    Search CenterWatch for drugs/clinical trials and news about POU4F1 / PO4F1 

    Transcripts
    for POU4F1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for POU4F1 gene: 
    NM_006237.3  

    Unigene Cluster for POU4F1:

    POU class 4 homeobox 1
    Hs.654522  [show with all ESTs]
    Unigene Representative Sequence: L20433
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377208(uc001vkv.3)

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    hsa-miR-520f hsa-miR-607 hsa-miR-300 hsa-miR-411 hsa-miR-138-2* hsa-miR-759 hsa-miR-642b hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmid: POU4F1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: L20433.1 

    1 DOTS entry:

    DT.405448 

    18 AceView cDNA sequences:

    BM726529 BM724195 BM930796 BM680352 CK299754 BM714015 AA779554 AA428196 
    AI039110 AW499868 L20433 BQ188526 BF509762 BM681187 T28997 BM684645 
    NM_006237 AA428894 

    GeneLoc Exon Structure


    Expression
    for POU4F1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU4F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATGTCTGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    POU4F1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeGanglion Cell LayerMature Ganglion CellsGanglion, Retina
    EyeGanglion Cell LayerImmature Ganglion CellsGanglion, Retina
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    BoneMaxillary ProcessBone
    BrainMedulla OblongataBrain
    EyeRetinaEye
    Neural TubeMetencephalonNeural Tube
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    Optic cup structures (Generation of strati...)
    Peripheral neuron-like cells (Derivation of neural...)
    Neural crest-like cells (Directed differentia...)
    Peripheral sensory neuron-like cells (Generation of neuros...)

    See POU4F1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POU4F1

    SOURCE GeneReport for Unigene cluster: Hs.654522

    UniProtKB/Swiss-Prot: PO4F1_HUMAN, Q01851
    Tissue specificity: Brain. Seems to be specific to the retina. Present in the developing brain, spinal cord and eye

        SABiosciences Expression via Pathway-Focused PCR Arrays including POU4F1: 
              Neurogenesis in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
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    Orthologs
    for POU4F1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for POU4F1 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008576231 POU domain, class 4, transcription factor 1-like 85.74(n)
    90.07(a)    		   100857623  XM_003640558.1  XP_003640606.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia brn3a-A2 class IV POU-homeodomain protein 79.73(n)    AF196575.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii pou4f12 POU domain, class 4, transcription factor 1 83.11(n)   58057  BC056326.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta acj63 synaptic target recognition RNA polymerase
    II transcription factor less    		 81(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-863 Pou homeodomain 75(a)   III(8284820-8288362)   --


    ENSEMBL Gene Tree for POU4F1 (if available)
    TreeFam Gene Tree for POU4F1 (if available) 

    Paralogs
    for POU4F1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POU4F1 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F42  POU3F12  POU1F12  POU4F32  
    POU3F32  POU3F22  POU2F22  POU5F1B2  POU2F12  POU5F12  POU6F12  
    6 SIMAP similar genes for POU4F1 using alignment to 1 protein entry:     PO4F1_HUMAN:
    POU1F1    POU6F1    POU4F3    POU3F1    POU4F2    POU3F3

    POU4F1 for paralogs           About GeneDecksing



    Genomic Variants
    for POU4F1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/105 NCBI SNPs in POU4F1 are shown (see all 105)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs15361781,2
    		C,F,A,H,--79172756(+) TCTCAA/GCTCTT 2 -- ds5001 int123Minor allele frequency- G:0.47NS EA NA WA CSA 2218
    rs15361791,2
    		C,F,H,--79172793(+) ATCTAG/ATCCCA 2 -- int1 ds50017Minor allele frequency- A:0.05EA NS NA 634
    rs1889980691,2
    		--79172801(+) CCAAGC/TCACCA 2 -- int1 ds50010--------
    rs1929612991,2
    		--79172814(+) AAATAA/GAGGCT 2 -- ds5001 int10--------
    rs1843257741,2
    		--79172844(+) GTAGGA/TGGCAC 2 -- int1 ds50010--------
    rs1484205921,2
    		--79172888(+) AAAAGA/CCATTC 2 -- ds5001 int10--------
    rs1887075181,2
    		--79172941(+) CCAAAC/TTCCTC 2 -- int1 ds50010--------
    rs1416947021,2
    		--79173123(+) AGTTAC/TCTGAA 2 -- int1 ds50010--------
    rs1810391261,2
    		--79173221(+) TTTGTA/GTTTTC 2 -- ds5001 int10--------
    rs1836921621,2
    		--79173309(+) AACTGC/TTCTTC 2 -- int1 ut310--------

    HapMap Linkage Disequilibrium report for POU4F1 (79173227 - 79177695 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for POU4F1
         3 CNVs: 71743 66492 53165

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    Disorders / Diseases
    for POU4F1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    POU4F1 for disorders           About GeneDecksing

    OMIM gene information: 601632    OMIM disorders: --

    20/24 diseases for POU4F1 (see all 24):    About MalaCards
    cervicitis    ceroid lipofuscinosis    neuronal ceroid-lipofuscinosis    acute myeloid leukemia
    retinitis    myeloid leukemia    systemic lupus erythematosus    lupus erythematosus
    herpes simplex    papilloma    cervical carcinoma    glaucoma
    cervical cancer    leukemia    cervical adenocarcinoma    sarcoma
    alzheimer's disease    adenocarcinoma    prostate cancer    breast cancer

    1 disease from the University of Copenhagen DISEASES database for POU4F1:
    Glaucoma

    7 Novoseek disease relationships for POU4F1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cervical abnormality 76.1 4 16126264 (1), 12893201 (1), 9541499 (1), 12911730 (1)
    papilloma 49 1 9541499 (1)
    cervical cancer 43.6 6 16247485 (1), 12893201 (1), 9541499 (1), 12911730 (1)
    cervical carcinoma 41.7 3 16247485 (1), 12431761 (1)
    cervical lesion 39 1 12893201 (1)
    ewings sarcoma 30.4 1 15147979 (1)
    tumors 0 14 16126264 (2), 10497216 (2), 12911730 (2), 12893201 (2) (see all 8)


    Export disorders for POU4F1 gene to outside databases

    Publications
    for POU4F1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU4F1 gene, integrated from 9 sources (see all 83):
    (articles sorted by number of sources associating them with POU4F1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system. (PubMed id 1357630)1, 2, 3 Collum R.G.... Alt F.W. (1992)
    2. The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. (PubMed id 7623109)1, 2, 9 Xiang M.... Nathans J. (1995)
    3. Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. (PubMed id 8234287)1, 2 Bhargava A.K.... Weissman S.M. (1993)
    4. Measurement of Brn-3a levels in Pap smears provides a novel diagnostic marker for the detection of cervical neoplasia. (PubMed id 12893201)1, 9 Sindos M....Latchman D.S. (2003)
    5. The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1. (PubMed id 15021903)1, 9 Gascoyne D.M....Latchman D.S. (2004)
    6. The Brn-3a transcription factor gene (POU4F1) maps close to the locus for the variant late infantile form of neuronal ceroid-lipofuscinosis. (PubMed id 8941380)1, 9 Still I.H. and Cowell J. (1996)
    7. Gene expression of the POU factor Brn-3a is regulated by two different promoters. (PubMed id 12427558)1, 9 Frass B....Moroy T. (2002)
    8. Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a. (PubMed id 16247485)1, 9 Ndisang D....Latchman D.S. (2006)
    9. Detection of cervical neoplasia using measurement of Brn-3a in cervical smears with persistent minor abnormality. (PubMed id 12911730)1, 9 Sindos M....Latchman D. (2003)
    10. Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor. (PubMed id 8995448)1, 9 Smith M.D....Latchman D.S. (1997)

    External Searches for POU4F1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing POU4F1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5457 HGNC: 9218 AceView: POU4F1 Ensembl:ENSG00000152192 euGenes: HUgn5457
    ECgene: POU4F1 H-InvDB: POU4F1

    Other Databases showing POU4F1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing POU4F1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POU4F1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POU4F1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for POU4F1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for POU4F1 gene:
    Search GeneIP for patents involving POU4F1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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