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Aliases for POU4F1 Gene

Aliases for POU4F1 Gene

  • POU Class 4 Homeobox 1 2 3 5
  • Brain-Specific Homeobox/POU Domain Protein 3A 3 4
  • Homeobox/POU Domain Protein RDC-1 3 4
  • Brain-3A 3 4
  • Brn-3A 3 4
  • Oct-T1 3 4
  • BRN3A 3 4
  • POU Domain Class 4, Transcription Factor 1 2
  • RDC-1 3
  • RDC1 4

External Ids for POU4F1 Gene

Previous HGNC Symbols for POU4F1 Gene

  • BRN3A

Previous GeneCards Identifiers for POU4F1 Gene

  • GC13M077140
  • GC13M073168
  • GC13M078109
  • GC13M076971
  • GC13M078071
  • GC13M079173
  • GC13M059873

Summaries for POU4F1 Gene

Entrez Gene Summary for POU4F1 Gene

  • This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012]

GeneCards Summary for POU4F1 Gene

POU4F1 (POU Class 4 Homeobox 1) is a Protein Coding gene. Diseases associated with POU4F1 include Cervical Cancer, Somatic and Papilloma. Among its related pathways are Gene Expression and Regulation of TP53 Activity. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is POU6F1.

UniProtKB/Swiss-Prot for POU4F1 Gene

  • Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.

Gene Wiki entry for POU4F1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU4F1 Gene

Genomics for POU4F1 Gene

Regulatory Elements for POU4F1 Gene

Enhancers for POU4F1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POU4F1 on UCSC Golden Path with GeneCards custom track

Genomic Location for POU4F1 Gene

Chromosome:
13
Start:
78,598,362 bp from pter
End:
78,603,560 bp from pter
Size:
5,199 bases
Orientation:
Minus strand

Genomic View for POU4F1 Gene

Genes around POU4F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POU4F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POU4F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU4F1 Gene

Proteins for POU4F1 Gene

  • Protein details for POU4F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01851-PO4F1_HUMAN
    Recommended name:
    POU domain, class 4, transcription factor 1
    Protein Accession:
    Q01851
    Secondary Accessions:
    • Q14986
    • Q15318
    • Q5T227

    Protein attributes for POU4F1 Gene

    Size:
    419 amino acids
    Molecular mass:
    42697 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA45907.1; Type=Frameshift; Positions=11, 13, 33, 43, 57, 61, 74, 76, 133, 135, 138, 340, 342; Evidence={ECO:0000305};

neXtProt entry for POU4F1 Gene

Proteomics data for POU4F1 Gene at MOPED

Post-translational modifications for POU4F1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU4F1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POU4F1 Gene

Domains & Families for POU4F1 Gene

Gene Families for POU4F1 Gene

Protein Domains for POU4F1 Gene

Suggested Antigen Peptide Sequences for POU4F1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01851

UniProtKB/Swiss-Prot:

PO4F1_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the POU transcription factor family. Class-4 subfamily.
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 POU-specific domain.
Family:
  • Belongs to the POU transcription factor family. Class-4 subfamily.
genes like me logo Genes that share domains with POU4F1: view

Function for POU4F1 Gene

Molecular function for POU4F1 Gene

GENATLAS Biochemistry:
POU domain,class 4,transcription factor 1,mammalian homeo box backfoot,Drosophila bicoid related,expressed in Rathke pouch at an early stage of pituitary development and in a subset of adult anterior pituitary cells that express POMC
UniProtKB/Swiss-Prot Function:
Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.

Gene Ontology (GO) - Molecular Function for POU4F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with POU4F1: view
genes like me logo Genes that share phenotypes with POU4F1: view

Animal Models for POU4F1 Gene

MGI Knock Outs for POU4F1:

Animal Model Products

miRNA for POU4F1 Gene

miRTarBase miRNAs that target POU4F1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POU4F1 Gene

Localization for POU4F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU4F1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POU4F1 Gene COMPARTMENTS Subcellular localization image for POU4F1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

No data available for Gene Ontology (GO) - Cellular Components for POU4F1 Gene

Pathways & Interactions for POU4F1 Gene

genes like me logo Genes that share pathways with POU4F1: view

Gene Ontology (GO) - Biological Process for POU4F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001967 suckling behavior IEA --
GO:0003223 ventricular compact myocardium morphogenesis IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007416 synapse assembly TAS 8995448
genes like me logo Genes that share ontologies with POU4F1: view

No data available for SIGNOR curated interactions for POU4F1 Gene

Drugs & Compounds for POU4F1 Gene

(3) Drugs for POU4F1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with POU4F1: view

Transcripts for POU4F1 Gene

mRNA/cDNA for POU4F1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POU4F1 Gene

POU class 4 homeobox 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POU4F1 Gene

No ASD Table

Relevant External Links for POU4F1 Gene

GeneLoc Exon Structure for
POU4F1
ECgene alternative splicing isoforms for
POU4F1

Expression for POU4F1 Gene

mRNA expression in normal human tissues for POU4F1 Gene

mRNA differential expression in normal tissues according to GTEx for POU4F1 Gene

This gene is overexpressed in Testis (x15.3) and Brain - Spinal cord (cervical c-1) (x5.0).

SOURCE GeneReport for Unigene cluster for POU4F1 Gene Hs.654522

mRNA Expression by UniProt/SwissProt for POU4F1 Gene

Q01851-PO4F1_HUMAN
Tissue specificity: Brain. Seems to be specific to the retina. Present in the developing brain, spinal cord and eye.
genes like me logo Genes that share expression patterns with POU4F1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for POU4F1 Gene

Orthologs for POU4F1 Gene

This gene was present in the common ancestor of animals.

Orthologs for POU4F1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Pou4f1 35
  • 94.03 (n)
  • 97.61 (a)
Pou4f1 16
Pou4f1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POU4F1 35
  • 99.2 (n)
  • 99.7 (a)
POU4F1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pou4f1 35
  • 96.35 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia POU4F1 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488759 35
  • 78.14 (n)
  • 88.84 (a)
African clawed frog
(Xenopus laevis)
Amphibia brn3a-A 35
zebrafish
(Danio rerio)
Actinopterygii pou4f1 35
  • 77.1 (n)
  • 83.18 (a)
pou4f1 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta acj6 37
  • 81 (a)
acj6 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-86 37
  • 75 (a)
unc-86 36
  • 43 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3277 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for POU4F1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POU4F1 Gene

ENSEMBL:
Gene Tree for POU4F1 (if available)
TreeFam:
Gene Tree for POU4F1 (if available)

Paralogs for POU4F1 Gene

(6) SIMAP similar genes for POU4F1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POU4F1: view

Variants for POU4F1 Gene

Structural Variations from Database of Genomic Variants (DGV) for POU4F1 Gene

Variant ID Type Subtype PubMed ID
dgv339n67 CNV Gain 20364138
dgv234n27 CNV Loss 19166990
nsv1097 CNV Insertion 18451855
nsv826725 CNV Gain 20364138
nsv826726 CNV Gain 20364138
esv27337 CNV Loss 19812545

Variation tolerance for POU4F1 Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.28% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for POU4F1 Gene

Disorders for POU4F1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for POU4F1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cervical cancer, somatic
  • cervical cancer
papilloma
  • papillomatosis
borderline glaucoma
  • preglaucoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POU4F1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POU4F1
genes like me logo Genes that share disorders with POU4F1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POU4F1 Gene

Publications for POU4F1 Gene

  1. A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system. (PMID: 1357630) Collum R.G. … Alt F.W. (Nucleic Acids Res. 1992) 2 3 4 67
  2. Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a. (PMID: 16247485) Ndisang D. … Latchman D.S. (Oncogene 2006) 3 23
  3. The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1. (PMID: 15021903) Gascoyne D.M. … Latchman D.S. (Oncogene 2004) 3 23
  4. Measurement of Brn-3a levels in Pap smears provides a novel diagnostic marker for the detection of cervical neoplasia. (PMID: 12893201) Sindos M. … Latchman D.S. (Gynecol. Oncol. 2003) 3 23
  5. Detection of cervical neoplasia using measurement of Brn-3a in cervical smears with persistent minor abnormality. (PMID: 12911730) Sindos M. … Latchman D. (Int. J. Gynecol. Cancer 2003) 3 23

Products for POU4F1 Gene

Sources for POU4F1 Gene

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