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POU4F1 Gene

protein-coding   GIFtS: 56
GCID: GC13M079173

POU Class 4 Homeobox 1

(Previous names: POU domain class 4, transcription factor 1)
(Previous symbol: BRN3A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
POU Class 4 Homeobox 11 2     brain-3A2
BRN3A1 2 3 5     brn-3A2
Brain-Specific Homeobox/POU Domain Protein 3A2 3     POU Domain, Class 4, Transcription Factor 12
Homeobox/POU Domain Protein RDC-12 3     Brain-3A3
Oct-T12 3     Brn-3A3
POU Domain Class 4, Transcription Factor 11     RDC13
RDC-12     

External Ids:    HGNC: 92181   Entrez Gene: 54572   Ensembl: ENSG000001521927   OMIM: 6016325   UniProtKB: Q018513   

Export aliases for POU4F1 gene to outside databases

Previous GC identifers: GC13M077140 GC13M073168 GC13M078109 GC13M076971 GC13M078071 GC13M059873


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POU4F1 Gene:
This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a
subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may
also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute
myeloid leukemias. (provided by RefSeq, Mar 2012)

GeneCards Summary for POU4F1 Gene:
POU4F1 (POU class 4 homeobox 1) is a protein-coding gene. Diseases associated with POU4F1 include cervicitis, and neuronal ceroid lipofuscinosis. GO annotations related to this gene include RNA polymerase II distal enhancer sequence-specific DNA binding and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO4F1_HUMAN, Q01851
Function: Probable transcription factor which may play a role in the regulation of specific gene expression within
a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of
visual system neurons

Gene Wiki entry for POU4F1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the POU4F1 gene promoter:
         E2F-3a   E2F-4   E2F-5   Sp1   E2F-2   Evi-1   S8   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOU4F1 promoter sequence
   Search Chromatin IP Primers for POU4F1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU4F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31.1   Ensembl cytogenetic band:  13q31.1   HGNC cytogenetic band: 13q31.1

POU4F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU4F1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M079173:  view genomic region     (about GC identifiers)

Start:
79,172,497 bp from pter      End:
79,177,695 bp from pter
Size:
5,199 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PO4F1_HUMAN, Q01851 (See protein sequence)
Recommended Name: POU domain, class 4, transcription factor 1  
Size: 419 amino acids; 42697 Da
Developmental stage: Expression peaks early in embryogenesis (day 13.5) and is undetectable 14 days after birth
Sequence caution: Sequence=CAA45907.1; Type=Frameshift; Positions=11, 13, 33, 43, 57, 61, 74, 76, 133, 135, 138,
340, 342;
Secondary accessions: Q14986 Q15318 Q5T227

Explore the universe of human proteins at neXtProt for POU4F1: NX_Q01851

Explore proteomics data for POU4F1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POU4F1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006228.3  
    ENSEMBL proteins: 
     ENSP00000366413  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POU: Homeoboxes / POU class

    Selected InterPro protein domains (see all 6):
     IPR010982 Lambda_DNA-bd_dom
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry Q01851

    ProtoNet protein and cluster: Q01851

    2 Blocks protein domains:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO4F1_HUMAN, Q01851
    Similarity: Belongs to the POU transcription factor family. Class-4 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    POU4F1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO4F1_HUMAN, Q01851
    Function: Probable transcription factor which may play a role in the regulation of specific gene expression within
    a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of
    visual system neurons

         Genatlas biochemistry entry for POU4F1:
    POU domain,class 4,transcription factor 1,mammalian homeo box backfoot,Drosophila bicoid related,expressed in
    Rathke pouch at an early stage of pituitary development and in a subset of adult anterior pituitary cells that
    express POMC

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding ISS--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ISS--
         
    POU4F1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for POU4F1:
     Decreased G3BP1 protein expres  Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Pou4f1):
     behavior/neurological  embryogenesis  mortality/aging  nervous system  vision/eye 

    POU4F1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for POU4F1: Pou4f1tm1Nat Pou4f1tm1Dsl Pou4f1tm1Rsd Pou4f1tm2Dsl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POU4F1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU4F1
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    miRNA
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    miRTarBase miRNAs that target POU4F1:
    hsa-mir-26b-5p (MIRT030102), hsa-mir-30b-5p (MIRT046165)

    Block miRNA regulation of human, mouse, rat POU4F1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate POU4F1 (see all 65):
    hsa-miR-520f hsa-miR-607 hsa-miR-300 hsa-miR-411 hsa-miR-138-2* hsa-miR-759 hsa-miR-642b hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidPOU4F1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat POU4F1

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU4F1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PO4F1_HUMAN, Q01851: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--
    GO:0005634nucleus ----
    GO:0043005neuron projection IEA--

    POU4F1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POU4F1 About    
    See pathways by source

    SuperPathContained pathways About
    1Direct p53 effectors
    Direct p53 effectors

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for POU4F1
        Transendothelial Migration of Leukocytes

    1 BioSystems Pathway for POU4F1
        Direct p53 effectors


        Pathway & Disease-focused RT2 Profiler PCR Arrays including POU4F1: 
              Neurogenesis in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for POU4F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for POU4F1 (Q018513 ENSP000003664134) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIT2Q995783, ENSP000003218054I2D: score=2 STRING: ENSP00000321805
    ESR1P033723, ENSP000002062494I2D: score=5 STRING: ENSP00000206249
    EWSR1Q018443, ENSP000003810314I2D: score=1 STRING: ENSP00000381031
    BAXENSP000002932884STRING: ENSP00000293288
    BCL2ENSP000003296234STRING: ENSP00000329623
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001967suckling behavior IEA--
    GO:0003223ventricular compact myocardium morphogenesis IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter ISS--

    POU4F1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POU4F1 (PO4F1)

    3 Novoseek inferred chemical compound relationships for POU4F1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    isoleucine 28.4 2 8662774 (1), 9223099 (1)
    valine 20.3 2 8662774 (1), 9223099 (1)
    nitric oxide 0 1 17702766 (1)



    POU4F1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for POU4F1 gene: 
    NM_006237.3  

    Unigene Cluster for POU4F1:

    POU class 4 homeobox 1
    Hs.654522  [show with all ESTs]
    Unigene Representative Sequence: L20433
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377208(uc001vkv.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat POU4F1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate POU4F1 (see all 65):
    hsa-miR-520f hsa-miR-607 hsa-miR-300 hsa-miR-411 hsa-miR-138-2* hsa-miR-759 hsa-miR-642b hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidPOU4F1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat POU4F1

    Additional mRNA sequence: L20433.1 

    1 DOTS entry:

    DT.405448 

    18 AceView cDNA sequences:

    BM680352 AA779554 BM714015 BM724195 BM726529 BM930796 CK299754 BM684645 
    NM_006237 AA428196 T28997 AW499868 AI039110 BM681187 BF509762 L20433 
    BQ188526 AA428894 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    POU4F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTCTGCT
    POU4F1 Expression
    About this image


    POU4F1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Ganglion Cells Ganglion Cell Layer
             Retina
             Optic cup structures
     
     Neurons
             Mature Ganglion Cells Ganglion Cell Layer
             Peripheral sensory neuron-like cells
     
     Neural Crest (Gastrulation Derivatives)
             Neural crest-like cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     NULL (Uncategorized)
             Peripheral neuron-like cells
    POU4F1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POU4F1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654522

    UniProtKB/Swiss-Prot: PO4F1_HUMAN, Q01851
    Tissue specificity: Brain. Seems to be specific to the retina. Present in the developing brain, spinal cord and
    eye

        Pathway & Disease-focused RT2 Profiler PCR Arrays including POU4F1: 
              Neurogenesis in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU4F1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for POU4F1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou4f11 , 5 POU domain, class 4, transcription factor 11, 5 94.03(n)1
    97.61(a)1
      14 (54.21 cM)5
    189961  NM_011143.41  NP_035273.31 
     1044623205 
    African clawed frog
    (Xenopus laevis)
    Amphibia brn3a-A2 class IV POU-homeodomain protein 79.73(n)    AF196575.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pou4f12 POU domain, class 4, transcription factor 1 83.11(n)   58057  BC056326.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta acj63 synaptic target recognition RNA
    polymerase II more
    81(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea unc-863 Pou homeodomain 75(a)   III(8284820-8288362)   --


    ENSEMBL Gene Tree for POU4F1 (if available)
    TreeFam Gene Tree for POU4F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POU4F1 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F12  POU3F42  POU1F12  POU3F32  
    POU4F32  POU3F22  POU2F22  POU5F1B2  POU2F12  POU6F12  POU5F12  
    6 SIMAP similar genes for POU4F1 using alignment to 1 protein entry:     PO4F1_HUMAN:
    POU1F1    POU6F1    POU4F3    POU3F1    POU4F2    POU3F3

    POU4F1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for POU4F1    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs711060401,2
    C--79178073(+) GTGTG-/TG/T  
     GTGTGTG
    CGTGC
    1 -- us2k11NA 2
    rs3770081651,2
    ----79178685(+) AGCGT-/ACACACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for POU4F1 (79172497 - 79177695 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for POU4F1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1097CNV Insertion18451855
    esv27337CNV Loss19812545
    dgv234n27CNV Loss19166990
    nsv826725CNV Gain20364138
    dgv339n67CNV Gain20364138
    nsv826726CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601632    OMIM disorders: --

    Selected diseases for POU4F1 (see all 21):    
    About MalaCards
    cervicitis    neuronal ceroid lipofuscinosis    cervical adenocarcinoma    myeloid leukemia
    cervical cancer    papilloma    acute myeloid leukemia    herpes simplex
    retinitis    systemic lupus erythematosus    leukemia    neuroblastoma
    glaucoma    lupus erythematosus    sarcoma    alzheimer's disease
    adenocarcinoma    prostate cancer    prostatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for POU4F1:
    Glaucoma

    POU4F1 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for POU4F1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cervical abnormality 76.1 4 16126264 (1), 12893201 (1), 9541499 (1), 12911730 (1)
    papilloma 49 1 9541499 (1)
    cervical cancer 43.6 6 16247485 (1), 12893201 (1), 9541499 (1), 12911730 (1)
    cervical carcinoma 41.7 3 16247485 (1), 12431761 (1)
    cervical lesion 39 1 12893201 (1)
    ewings sarcoma 30.4 1 15147979 (1)
    tumors 0 14 16126264 (2), 10497216 (2), 12911730 (2), 12893201 (2) (see all 8)


    Export disorders for POU4F1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POU4F1 gene, integrated from 10 sources (see all 85):
    (articles sorted by number of sources associating them with POU4F1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system. (PubMed id 1357630)1, 2, 3 Collum R.G.... Alt F.W. (Nucleic Acids Res. 1992)
    2. The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. (PubMed id 7623109)1, 2, 9 Xiang M.... Nathans J. (J. Neurosci. 1995)
    3. Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. (PubMed id 8234287)1, 2 Bhargava A.K.... Weissman S.M. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    4. Measurement of Brn-3a levels in Pap smears provides a novel diagnostic marker for the detection of cervical neoplasia. (PubMed id 12893201)1, 9 Sindos M....Latchman D.S. (Gynecol. Oncol. 2003)
    5. The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1. (PubMed id 15021903)1, 9 Gascoyne D.M....Latchman D.S. (Oncogene 2004)
    6. The Brn-3a transcription factor gene (POU4F1) maps close to the locus for the variant late infantile form of neuronal ceroid-lipofuscinosis. (PubMed id 8941380)1, 9 Still I.H. and Cowell J. (Cytogenet. Cell Genet. 1996)
    7. Gene expression of the POU factor Brn-3a is regulated by two different promoters. (PubMed id 12427558)1, 9 Frass B....MAPrAPy T. (Biochim. Biophys. Acta 2002)
    8. Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a. (PubMed id 16247485)1, 9 Ndisang D....Latchman D.S. (Oncogene 2006)
    9. Detection of cervical neoplasia using measurement of Brn-3a in cervical smears with persistent minor abnormality. (PubMed id 12911730)1, 9 Sindos M....Latchman D. (Int. J. Gynecol. Cancer 2003)
    10. Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor. (PubMed id 8995448)1, 9 Smith M.D....Latchman D.S. (J. Biol. Chem. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5457 HGNC: 9218 AceView: POU4F1 Ensembl:ENSG00000152192 euGenes: HUgn5457
    ECgene: POU4F1 H-InvDB: POU4F1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POU4F1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POU4F1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POU4F1 gene:
    Search GeneIP for patents involving POU4F1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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