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Aliases for POU3F3 Gene

Aliases for POU3F3 Gene

  • POU Class 3 Homeobox 3 2 3
  • Brain-Specific Homeobox/POU Domain Protein 1 3 4
  • Octamer-Binding Transcription Factor 8 3 4
  • Octamer-Binding Protein 8 3 4
  • Brain-1 3 4
  • Oct-8 3 4
  • BRN1 3 4
  • OTF8 3 4
  • POU Domain, Class 3, Transcription Factor 3 3
  • POU Domain Class 3, Transcription Factor 3 2
  • Brn-1 4
  • OTF-8 4

External Ids for POU3F3 Gene

Previous GeneCards Identifiers for POU3F3 Gene

  • GC02P103336
  • GC02P103924
  • GC02P105076
  • GC02P105093
  • GC02P104930
  • GC02P105471
  • GC02P099242

Summaries for POU3F3 Gene

Entrez Gene Summary for POU3F3 Gene

  • This gene encodes a POU-domain containing protein that functions as a transcription factor. The encoded protein recognizes an octamer sequence in the DNA of target genes. This protein may play a role in development of the nervous system. [provided by RefSeq, Apr 2015]

GeneCards Summary for POU3F3 Gene

POU3F3 (POU Class 3 Homeobox 3) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and HMG box domain binding. An important paralog of this gene is POU6F1.

UniProtKB/Swiss-Prot for POU3F3 Gene

  • Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5-ATTTGCAT-3) (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU3F3 Gene

Genomics for POU3F3 Gene

Regulatory Elements for POU3F3 Gene

Genomic Location for POU3F3 Gene

Start:
104,855,511 bp from pter
End:
104,860,471 bp from pter
Size:
4,961 bases
Orientation:
Plus strand

Genomic View for POU3F3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POU3F3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU3F3 Gene

Proteins for POU3F3 Gene

  • Protein details for POU3F3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20264-PO3F3_HUMAN
    Recommended name:
    POU domain, class 3, transcription factor 3
    Protein Accession:
    P20264
    Secondary Accessions:
    • P78379
    • Q4ZG25

    Protein attributes for POU3F3 Gene

    Size:
    500 amino acids
    Molecular mass:
    50327 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POU3F3 Gene

Proteomics data for POU3F3 Gene at MOPED

Post-translational modifications for POU3F3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU3F3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POU3F3 Gene

Domains for POU3F3 Gene

Gene Families for POU3F3 Gene

HGNC:
  • POU :Homeoboxes / POU class

Protein Domains for POU3F3 Gene

Suggested Antigen Peptide Sequences for POU3F3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20264

UniProtKB/Swiss-Prot:

PO3F3_HUMAN :
  • P20264
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 POU-specific domain.
Family:
  • Belongs to the POU transcription factor family. Class-3 subfamily.
genes like me logo Genes that share domains with POU3F3: view

Function for POU3F3 Gene

Molecular function for POU3F3 Gene

GENATLAS Biochemistry: POU domain,class 3,transcription factor 3,expressed in brain
UniProtKB/Swiss-Prot Function: Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5-ATTTGCAT-3) (By similarity).

Gene Ontology (GO) - Molecular Function for POU3F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding --
GO:0043565 sequence-specific DNA binding ISS --
GO:0071837 HMG box domain binding IEA --
genes like me logo Genes that share ontologies with POU3F3: view
genes like me logo Genes that share phenotypes with POU3F3: view

Animal Models for POU3F3 Gene

MGI Knock Outs for POU3F3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for POU3F3 Gene

Localization for POU3F3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU3F3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POU3F3 Gene COMPARTMENTS Subcellular localization image for POU3F3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for POU3F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with POU3F3: view

Pathways for POU3F3 Gene

SuperPathways for POU3F3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for POU3F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007417 central nervous system development TAS 8703082
GO:0008284 positive regulation of cell proliferation ISS --
genes like me logo Genes that share ontologies with POU3F3: view

No data available for Pathways by source for POU3F3 Gene

Transcripts for POU3F3 Gene

mRNA/cDNA for POU3F3 Gene

(0) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POU3F3 Gene

POU class 3 homeobox 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POU3F3 Gene

No ASD Table

Relevant External Links for POU3F3 Gene

GeneLoc Exon Structure for
POU3F3
ECgene alternative splicing isoforms for
POU3F3

Expression for POU3F3 Gene

mRNA expression in normal human tissues for POU3F3 Gene

mRNA differential expression in normal tissues according to GTEx for POU3F3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.3), Brain - Hippocampus (4.3), Brain - Substantia nigra (4.3), Brain - Anterior cingulate cortex (BA24) (4.1), Brain - Amygdala (4.1), and Brain - Caudate (basal ganglia) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POU3F3 Gene

SOURCE GeneReport for Unigene cluster for POU3F3 Gene Hs.673855

mRNA Expression by UniProt/SwissProt for POU3F3 Gene

P20264-PO3F3_HUMAN
Tissue specificity: Brain
genes like me logo Genes that share expressions with POU3F3: view

Orthologs for POU3F3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POU3F3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia POU3F3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pou3f3 35
  • 89.54 (n)
  • 96.38 (a)
Pou3f3 16
Pou3f3 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POU3F3 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pou3f3 35
  • 89.6 (n)
  • 96.18 (a)
lizard
(Anolis carolinensis)
Reptilia POU3F3 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497507 35
  • 76.51 (n)
  • 84.21 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
pou3f3a 36
  • 75 (a)
OneToMany
pou3f3b 35
  • 74.92 (n)
  • 82.52 (a)
pou3f3b 36
  • 79 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta vvl 36
  • 48 (a)
OneToMany
nub 37
  • 64 (a)
vvl 37
  • 81 (a)
pdm2 37
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea ceh-6 37
  • 69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YOX1 38
Species with no ortholog for POU3F3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POU3F3 Gene

ENSEMBL:
Gene Tree for POU3F3 (if available)
TreeFam:
Gene Tree for POU3F3 (if available)

Paralogs for POU3F3 Gene

Selected SIMAP similar genes for POU3F3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POU3F3: view

Variants for POU3F3 Gene

Sequence variations from dbSNP and Humsavar for POU3F3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs732278 -- 104,857,240(-) TGGTC(A/C)GTTTC downstream-variant-500B
rs3739155 -- 104,855,039(+) GGGAG(C/T)CCGCG upstream-variant-2KB
rs72947661 -- 104,853,617(+) TCTCT(A/G)GCGGG upstream-variant-2KB
rs77739424 -- 104,854,515(+) TTTTT(C/T)CCTGT upstream-variant-2KB
rs113189120 -- 104,855,266(+) TGCCG(A/G)GCGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for POU3F3 Gene

Variant ID Type Subtype PubMed ID
nsv829586 CNV Gain 20364138
nsv829587 CNV Loss 20364138
dgv658n67 CNV Gain 20364138
nsv874756 CNV Loss 21882294
nsv829589 CNV Gain 20364138
nsv874757 CNV Loss 21882294
esv2660782 CNV Deletion 23128226
esv2661949 CNV Deletion 23128226
nsv829597 CNV Gain 20364138

Relevant External Links for POU3F3 Gene

HapMap Linkage Disequilibrium report
POU3F3
Human Gene Mutation Database (HGMD)
POU3F3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU3F3 Gene

Disorders for POU3F3 Gene

Relevant External Links for POU3F3

Human Genome Epidemiology (HuGE) Navigator
POU3F3
genes like me logo Genes that share disorders with POU3F3: view

No data available for UniProtKB/Swiss-Prot for POU3F3 Gene

Publications for POU3F3 Gene

  1. Expression of a large family of POU-domain regulatory genes in mammalian brain development. (PMID: 2739723) He X. … Rosenfeld M.G. (Nature 1989) 3 4
  2. Class III POU genes: generation of homopolymeric amino acid repeats under GC pressure in mammals. (PMID: 8703082) Sumiyama K. … Ueda S. (J. Mol. Evol. 1996) 3 4
  3. Cooperative function of POU proteins and SOX proteins in glial cells. (PMID: 9632656) Kuhlbrodt K. … Wegner M. (J. Biol. Chem. 1998) 3 23
  4. The J domain of papovaviral large tumor antigen is required for synergistic interaction with the POU-domain protein Tst-1/Oct6/SCIP. (PMID: 10082511) Sock E. … Wegner M. (Mol. Cell. Biol. 1999) 23
  5. Expression of transcription factors during oligodendroglial development. (PMID: 11276127) Wegner M. (Microsc. Res. Tech. 2001) 23

Products for POU3F3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate POU3F3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for POU3F3
    • Block miRNA regulation of POU3F3 using miScript Target Protectors

    Sources for POU3F3 Gene

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