POU3F3 Gene
protein-coding GIFtS : 52 GCID: GC02 P105471
POU class 3 homeobox 3 POU domain class 3, transcription factor 3 )
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Aliasesfor POU3F3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases POU Class 3 Homeobox 3 1 2 Brain-13 BRN11 2 3 Brn-13 OTF81 2 3 Oct-83 Brain-Specific Homeobox/POU Domain Protein 12 3 POU Domain, Class 3, Transcription Factor 32 Octamer-Binding Protein 82 3 Brain-13 Octamer-Binding Transcription Factor 82 3 Brn-13 OTF-82 3 Oct-83 POU Domain Class 3, Transcription Factor 31
Export aliases for POU3F3 gene to outside databases Previous GC identifers: GC02P103336 GC02P103924 GC02P105076 GC02P105093 GC02P104930 GC02P099242
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Summariesfor POU3F3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for POU3F3 : POU3F3 is a member of the class III POU family of transcription factors (see POU3F1; MIM 602479) that are expressed in the central nervous system. The POU domain in these proteins is required for high affinity binding to octamer DNA sequences (summarized by Sumiyama et al., 1996 (PubMed 8703082)).(supplied by OMIM, Jul 2010) UniProtKB/Swiss-Prot: PO3F3_HUMAN, P20264 Function : Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Isimplicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity)
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Genomic Viewsfor POU3F3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_022171.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the POU3F3 gene promoter:GR FOXF2 Pax-5 Bach2 CUTL1 N-Myc PPAR-gamma1 Chx10 PPAR-gamma2 GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for POU3F3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q12.1 Ensembl cytogenetic band: 2q12.1 HGNC cytogenetic band: 2q12.1 POU3F3 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02P105471: view genomic region
(about GC identifiers )
Start: 105,471,969 bp from pter End:
105,476,929 bp from pter
Size: 4,961 bases Orientation:
plus strand
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Proteinsfor POU3F3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PO3F3_HUMAN, P20264 See
protein sequence )Recommended Name: Size : 500 amino acids; 50327 DaSubcellular location : NucleusSecondary accessions : P78379 Q4ZG25Explore the universe of human proteins at neXtProt for POU3F3: NX_P20264 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P20264 POU3F3 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_006227.1 ENSEMBL proteins: ENSP00000355001 Human Recombinant Protein Products for POU3F3: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
ISS --
About GeneDecksing POU3F3 Antibody Products: Assay Products for POU3F3:
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Protein
Domains /for POU3F3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry P20264 ProtoNet protein and cluster: P20264
2 Blocks protein families : IPB000327 IPB013847 UniProtKB/Swiss-Prot: PO3F3_HUMAN, P20264 Similarity : Belongs to the POU transcription factor family. Class-3 subfamilySimilarity : Contains 1 homeobox DNA-binding domainSimilarity : Contains 1 POU-specific domain
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Functionfor POU3F3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: PO3F3_HUMAN, P20264 Function : Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Isimplicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity)
Genatlas biochemistry entry for POU3F3 POU domain,class 3,transcription factor 3,expressed in brain Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding
-- -- GO:0003700 sequence-specific DNA binding transcription factor activity
IEA -- GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
-- -- GO:0005515 protein binding
-- -- GO:0016563 transcription activator activity
-- --
About GeneDecksing Phenotypes: 2 GenomeRNAi human phenotypes for POU3F3 :8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pou3f3) :About GeneDecksing Animal Models: Pou3f3 tm1Rmc Pou3f3 tm1Tno Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: POU3F3 (NM_006236 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POU3F3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat POU3F3
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Pathways & Interactionsfor POU3F3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Transcription factors in neurogenesis
Pathway sources See GeneCards unified pathways Show all pathways 1 About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POU3F3 STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)5/13 Interacting proteins for POU3F3 (P20264 2 , 3 ENSP00000355001 4 via UniProtKB, MINT, STRING , and/or I2D (see all 13 )About this table Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000122 negative regulation of transcription from RNA polymerase II promoter
-- -- GO:0001822 kidney development
-- -- GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
-- -- GO:0007417 central nervous system development
TAS 8703082
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Drugs & Compoundsfor POU3F3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for POU3F3 POU3F3 / PO3F3
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Transcriptsfor POU3F3 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for POU3F3 gene: NM_006236.1 Unigene Cluster for POU3F3:
POU class 3 homeobox 3 Hs.673855 [show with all ESTs ] Unigene Representative Sequence: NM_006236 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000361360 (uc010ywg.2 ) Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: POU3F3 (NM_006236 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POU3F3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat POU3F3
1 DOTS entry : DT.95081172
10 AceView cDNA sequences :
NM_006236 F11569 BI464570 BF341357 BF355891 BF511732 AI796236 BX418484 BG911951 AF067777 GeneLoc Exon Structure
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Expression for POU3F3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section POU3F3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ACGCCGCCCGAbout this image POU3F3 expression in embryonic tissues and stem cells About this table
See POU3F3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for POU3F3 SOURCE GeneReport for Unigene cluster: Hs.673855 UniProtKB/Swiss-Prot: PO3F3_HUMAN, P20264 Tissue specificity : BrainSABiosciences Expression via Pathway-Focused PCR Arrays including POU3F3 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
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Orthologsfor POU3F3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for POU3F3 gene from 6/17 species (see all 17 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves LOC1008574221
POU domain, class 3, transcription factor 4-like
89.54(n) 91.67(a)
100857422 XM_003641077.1 XP_003641125.1
lizard Reptilia O73627_ANOCA6
Brain-1 gene
74(a)
1 ↔ 1
GL343243.1(157682-159046)
zebrafish Actinopterygii Y07906.12
--
76.06(n)
30386 Y07906.1
fruit fly Insecta vvl1 3
peripheral nervous system development DNA3 1
81(a) 3 64.29(n) 1 64.29(a) 1
3 65C53 38752 1 NM_001169884.1 1 NP_001163355.1 1
worm Secernentea ceh-63
Homeobox domain, Pou domain - N-terminal tomore
69(a)
I(8506480-8510320) --
rice Liliopsida AK060806.12
--
73.23(n)
AK060806.1
ENSEMBL Gene Tree for POU3F3 (if available)TreeFam Gene Tree for POU3F3 (if available)
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Paralogsfor POU3F3 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for POU3F3 gene POU5F2 2 POU6F2 2 POU4F2 2 POU2F3 2 POU3F4 2 POU3F1 2 POU1F1 2 POU4F3 2 POU3F2 2 POU2F2 2 POU5F1B 2 POU2F1 2 POU4F1 2 POU5F1 2 POU6F1 2 11 SIMAP similar genes for POU3F3 using alignment to 1 protein entry: PO3F3_HUMAN :POU6F1 POU1F1 POU3F2 POU5F1P4 POU3F1 POU3F4 POU2F1 POU4F3 POU2F3 POU4F1 POU4F2 About GeneDecksing
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Genomic Variantsfor POU3F3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 2 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for POU3F3 (105471969 - 105476929 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for POU3F3: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor POU3F3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 602480
OMIM disorders : --2 : About MalaCards cerebritis neuronitis Human Genome Epidemiology (HuGE) Navigator: POU3F3 (1 document)Export disorders for POU3F3 gene to outside databases
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Publicationsfor POU3F3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for POU3F3 gene, integrated from 9 sources (see all 14 ):(articles sorted by number of sources associating them with POU3F3) Utopia : connect your pdf to the dynamic
Class III POU genes: generation of homopolymeric amino acid repeats under GC pressure in mammals. (PubMed id 8703082) 1 , 2 (1996) Expression of a large family of POU-domain regulatory genes in mammalian brain development. (PubMed id 2739723) 1 , 2 (1989) Cooperative function of POU proteins and SOX proteins in glial cells. (PubMed id 9632656) 1 , 9(1998) The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. (PubMed id 16582099) 1 (2006) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 1 (2005) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 2 (2005) Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2. (PubMed id 9457692) 1 (1998) The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U. (PubMed id 9105675) 1 (1997) Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region. (PubMed id 15872005) 9 Bouchard M....Busslinger M. (2005) Redundancy of class III POU proteins in the oligodendrocyte lineage. (PubMed id 9405434) 9 Schreiber J....Wegner M. (1997)
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External Searches for POU3F3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing POU3F3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing POU3F3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing POU3F3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for POU3F3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for POU3F3 gene: POU3F3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor POU3F3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for POU3F3 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for POU3F3 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for POU3F3 OriGene Custom Protein Services for POU3F3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POU3F3 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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ThermoFisher Antibodies for POU3F3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat POU3F3
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Aliases for POU3F3
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Disorders / Diseases for POU3F3
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Drugs / Compounds for POU3F3
Expression for POU3F3
Function for POU3F3
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Expression by the Database of Embryonic development, Stem cell research, and
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