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Aliases for POU3F3 Gene

Aliases for POU3F3 Gene

  • POU Class 3 Homeobox 3 2 3 5
  • Brain-Specific Homeobox/POU Domain Protein 1 3 4
  • Octamer-Binding Transcription Factor 8 3 4
  • Octamer-Binding Protein 8 3 4
  • Brain-1 3 4
  • Oct-8 3 4
  • BRN1 3 4
  • OTF8 3 4
  • POU Domain, Class 3, Transcription Factor 3 3
  • POU Domain Class 3, Transcription Factor 3 2
  • Brn-1 4
  • OTF-8 4

External Ids for POU3F3 Gene

Previous GeneCards Identifiers for POU3F3 Gene

  • GC02P103336
  • GC02P103924
  • GC02P105076
  • GC02P105093
  • GC02P104930
  • GC02P105471
  • GC02P099242

Summaries for POU3F3 Gene

Entrez Gene Summary for POU3F3 Gene

  • This gene encodes a POU-domain containing protein that functions as a transcription factor. The encoded protein recognizes an octamer sequence in the DNA of target genes. This protein may play a role in development of the nervous system. [provided by RefSeq, Apr 2015]

GeneCards Summary for POU3F3 Gene

POU3F3 (POU Class 3 Homeobox 3) is a Protein Coding gene. Diseases associated with POU3F3 include Central Nervous System Tuberculosis and Epidemic Typhus. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and HMG box domain binding. An important paralog of this gene is POU3F2.

UniProtKB/Swiss-Prot for POU3F3 Gene

  • Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5-ATTTGCAT-3) (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU3F3 Gene

Genomics for POU3F3 Gene

Regulatory Elements for POU3F3 Gene

Enhancers for POU3F3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around POU3F3 on UCSC Golden Path with GeneCards custom track

Genomic Location for POU3F3 Gene

Chromosome:
2
Start:
104,855,511 bp from pter
End:
104,858,574 bp from pter
Size:
3,064 bases
Orientation:
Plus strand

Genomic View for POU3F3 Gene

Genes around POU3F3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POU3F3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POU3F3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU3F3 Gene

Proteins for POU3F3 Gene

  • Protein details for POU3F3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20264-PO3F3_HUMAN
    Recommended name:
    POU domain, class 3, transcription factor 3
    Protein Accession:
    P20264
    Secondary Accessions:
    • P78379
    • Q4ZG25

    Protein attributes for POU3F3 Gene

    Size:
    500 amino acids
    Molecular mass:
    50327 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POU3F3 Gene

Post-translational modifications for POU3F3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU3F3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POU3F3 Gene

Domains & Families for POU3F3 Gene

Gene Families for POU3F3 Gene

Protein Domains for POU3F3 Gene

Suggested Antigen Peptide Sequences for POU3F3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20264

UniProtKB/Swiss-Prot:

PO3F3_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the POU transcription factor family. Class-3 subfamily.
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 POU-specific domain.
Family:
  • Belongs to the POU transcription factor family. Class-3 subfamily.
genes like me logo Genes that share domains with POU3F3: view

Function for POU3F3 Gene

Molecular function for POU3F3 Gene

GENATLAS Biochemistry:
POU domain,class 3,transcription factor 3,expressed in brain
UniProtKB/Swiss-Prot Function:
Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5-ATTTGCAT-3) (By similarity).

Gene Ontology (GO) - Molecular Function for POU3F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IEA --
GO:0043565 sequence-specific DNA binding IEA,ISS --
GO:0071837 HMG box domain binding IEA --
genes like me logo Genes that share ontologies with POU3F3: view
genes like me logo Genes that share phenotypes with POU3F3: view

Animal Models for POU3F3 Gene

MGI Knock Outs for POU3F3:

Animal Model Products

CRISPR Products

Targeted motifs for POU3F3 Gene
HOMER Transcription Factor Regulatory Elements motif POU3F3
  • Consensus sequence: TATGCWAATBAV Submotif: canonical Cell Type: NPC GEO ID: GSE35496

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for POU3F3 Gene

Localization for POU3F3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU3F3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POU3F3 Gene COMPARTMENTS Subcellular localization image for POU3F3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for POU3F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
genes like me logo Genes that share ontologies with POU3F3: view

Pathways & Interactions for POU3F3 Gene

SuperPathways for POU3F3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for POU3F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007417 central nervous system development TAS 8703082
GO:0008284 positive regulation of cell proliferation IEA,ISS --
GO:0010628 positive regulation of gene expression ISS --
GO:0021799 cerebral cortex radially oriented cell migration IEA --
genes like me logo Genes that share ontologies with POU3F3: view

No data available for Pathways by source and SIGNOR curated interactions for POU3F3 Gene

Drugs & Compounds for POU3F3 Gene

No Compound Related Data Available

Transcripts for POU3F3 Gene

mRNA/cDNA for POU3F3 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POU3F3 Gene

POU class 3 homeobox 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POU3F3 Gene

No ASD Table

Relevant External Links for POU3F3 Gene

GeneLoc Exon Structure for
POU3F3
ECgene alternative splicing isoforms for
POU3F3

Expression for POU3F3 Gene

mRNA expression in normal human tissues for POU3F3 Gene

mRNA differential expression in normal tissues according to GTEx for POU3F3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.3), Brain - Hippocampus (x4.3), Brain - Substantia nigra (x4.3), Brain - Anterior cingulate cortex (BA24) (x4.1), Brain - Amygdala (x4.1), and Brain - Caudate (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for POU3F3 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POU3F3 Gene



Protein tissue co-expression partners for POU3F3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POU3F3 Gene:

POU3F3

SOURCE GeneReport for Unigene cluster for POU3F3 Gene:

Hs.673855

mRNA Expression by UniProt/SwissProt for POU3F3 Gene:

P20264-PO3F3_HUMAN
Tissue specificity: Brain.
genes like me logo Genes that share expression patterns with POU3F3: view

Primer Products

Orthologs for POU3F3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POU3F3 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Pou3f3 34
  • 89.54 (n)
  • 96.38 (a)
Pou3f3 16
Pou3f3 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pou3f3 34
  • 89.6 (n)
  • 96.18 (a)
dog
(Canis familiaris)
Mammalia POU3F3 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POU3F3 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 71 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia POU3F3 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497507 34
  • 76.51 (n)
  • 84.21 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 34
pou3f3b 34
  • 74.92 (n)
  • 82.52 (a)
pou3f3a 35
  • 75 (a)
OneToMany
pou3f3b 35
  • 79 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta nub 36
  • 64 (a)
pdm2 36
  • 61 (a)
vvl 36
  • 81 (a)
vvl 35
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-6 36
  • 69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YOX1 37
Species where no ortholog for POU3F3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POU3F3 Gene

ENSEMBL:
Gene Tree for POU3F3 (if available)
TreeFam:
Gene Tree for POU3F3 (if available)

Paralogs for POU3F3 Gene

(10) SIMAP similar genes for POU3F3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POU3F3: view

Variants for POU3F3 Gene

Sequence variations from dbSNP and Humsavar for POU3F3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6725560 -- 104,858,872(+) GCGAT(A/G)CCTGT downstream-variant-500B
rs732278 -- 104,857,240(-) TGGTC(A/C)GTTTC utr-variant-3-prime
rs12996884 -- 104,858,801(+) CTCTC(C/T)CTTAA downstream-variant-500B
rs10427165 -- 104,857,972(+) GCCAG(C/T)GAGGC utr-variant-3-prime
rs56376358 -- 104,857,762(+) AAAAA(-/A)TAATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for POU3F3 Gene

Variant ID Type Subtype PubMed ID
dgv658n67 CNV gain 20364138
esv2660782 CNV deletion 23128226
esv2661949 CNV deletion 23128226
nsv1072960 CNV deletion 25765185
nsv1126557 CNV deletion 24896259
nsv1136303 CNV deletion 24896259
nsv829586 CNV gain 20364138
nsv829587 CNV loss 20364138
nsv829589 CNV gain 20364138
nsv829597 CNV gain 20364138

Variation tolerance for POU3F3 Gene

Gene Damage Index Score: 1.20; 24.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POU3F3 Gene

Human Gene Mutation Database (HGMD)
POU3F3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
POU3F3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU3F3 Gene

Disorders for POU3F3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for POU3F3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
central nervous system tuberculosis
  • intracranial tuberculoma
epidemic typhus
  • sylvatic typhus
agraphia
writing disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POU3F3

Human Genome Epidemiology (HuGE) Navigator
POU3F3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POU3F3
genes like me logo Genes that share disorders with POU3F3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POU3F3 Gene

Publications for POU3F3 Gene

  1. Cooperative function of POU proteins and SOX proteins in glial cells. (PMID: 9632656) Kuhlbrodt K. … Wegner M. (J. Biol. Chem. 1998) 3 22 65
  2. Class III POU genes: generation of homopolymeric amino acid repeats under GC pressure in mammals. (PMID: 8703082) Sumiyama K. … Ueda S. (J. Mol. Evol. 1996) 3 4 65
  3. Expression of a large family of POU-domain regulatory genes in mammalian brain development. (PMID: 2739723) He X. … Rosenfeld M.G. (Nature 1989) 3 4 65
  4. Functional linc-POU3F3 is overexpressed and contributes to tumorigenesis in glioma. (PMID: 25445282) Guo H. … Zhu X. (Gene 2015) 3 65
  5. A de novo POU3F3 Deletion in a Boy with Intellectual Disability and Dysmorphic Features. (PMID: 24550763) Dheedene A. … Menten B. (Mol Syndromol 2014) 3 65

Products for POU3F3 Gene

Sources for POU3F3 Gene

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