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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU3F2 Gene

protein-coding   GIFtS: 59
GCID: GC06P099295

POU class 3 homeobox 2

(Previous names: POU domain class 3, transcription factor 2 )
(Previous symbol: OTF7)
 Explore 11 diseases affiliated with
POU3F2 via our new
 Human Malady Compendium 
Biological research products
for POU3F2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
POU Class 3 Homeobox 21 2     POU Domain Class 3, Transcription Factor 21
OCT71 2 3 5     N-Oct32
BRN21 2 3     Brain-23
OTF71 2 3     Brn-23
POUF31 2     Oct-73
Brain-Specific Homeobox/POU Domain Protein 22 3     POU Domain, Class 3, Transcription Factor 22
Nervous System-Specific Octamer-Binding Transcription Factor N-Oct-32 3     Brain-23
Octamer-Binding Protein 72 3     Brn-23
Octamer-Binding Transcription Factor 72 3     Oct-73
OTF-72 3     

External Ids:    HGNC: 92151   Entrez Gene: 54542   Ensembl: ENSG000001844867   OMIM: 6004945   UniProtKB: P202653   

Export aliases for POU3F2 gene to outside databases

Previous GC identifers: GC06P099150 GC06P099299 GC06P099328 GC06P099389 GC06P096721


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POU3F2:
This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in
neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes.
Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. (provided by
RefSeq, Mar 2012)

UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265
Function: Transcription factor that binds preferentially to the recognition sequence which consists of two distinct
half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively
regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity)

Gene Wiki entry for POU3F2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU3F2 gene promoter:
         TBP   AhR   C/EBPbeta   Pax-5   Tal-1   FOXD3   Arnt   E47   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOU3F2 promoter sequence
   Search SABiosciences Chromatin IP Primers for POU3F2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU3F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16   Ensembl cytogenetic band:  6q16.1   HGNC cytogenetic band: 6q16.2

POU3F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU3F2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P099295:  view genomic region     (about GC identifiers)

Start:
99,282,580 bp from pter      End:
99,286,666 bp from pter
Size:
4,087 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265 (See protein sequence)
Recommended Name: POU domain, class 3, transcription factor 2  
Size: 443 amino acids; 46893 Da
Subunit: Interacts with PQBP1
Subcellular location: Nucleus
Secondary accessions: Q14960 Q86V54 Q9UJL0
Alternative initiation: 3 isoforms:  P20265-1   P20265-2   P20265-3   

Explore the universe of human proteins at neXtProt for POU3F2: NX_P20265

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P20265

  • POU3F2 Protein expression data from MOPED and PaxDb:    About this image 
    POU3F2 Protein Expression
    REFSEQ proteins: NP_005595.2  
    ENSEMBL proteins: 
     ENSP00000329170  

    Human Recombinant Protein Products for POU3F2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: POU3F2
    OriGene Protein Over-expression Lysate: POU3F2
    OriGene Custom Protein Services for POU3F2 
    GenScript Custom Purified and Recombinant Proteins Services for POU3F2
    Novus Biologicals POU3F2 Proteins
    Novus Biologicals POU3F2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005667transcription factor complex IEA--

    POU3F2 for ontologies           About GeneDecksing



    POU3F2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of POU3F2
    R&D Systems Antibodies for POU3F2
    Cell Signaling Technology (CST) Antibodies for POU3F2  (7-Oct)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for POU3F2 
    GenScript Custom Superior Antibodies Services for POU3F2
    Novus Biologicals POU3F2 Antibodies
    Abcam antibodies for POU3F2 
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for POU3F2

    Assay Products for POU3F2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POU3F2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    POU3F2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR016362 Transcription_factor_POU
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS

    Graphical View of Domain Structure for InterPro Entry P20265

    ProtoNet protein and cluster: P20265

    2 Blocks protein families:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265
    Similarity: Belongs to the POU transcription factor family. Class-3 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO3F2_HUMAN, P20265
    Function: Transcription factor that binds preferentially to the recognition sequence which consists of two distinct
    half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively
    regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity)

         Genatlas biochemistry entry for POU3F2:
    POU domain,class 3,transcription factor 2,murine brain-2 (Brn-2) homolog

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001105RNA polymerase II transcription coactivator activity IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI11029584
    GO:0042802identical protein binding IPI11029584
         
    POU3F2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for POU3F2:
     Decreased Hepatitis C virus re 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pou3f2):
     adipose tissue  cellular  endocrine/exocrine gland  growth/size  integument 
     liver/biliary system  mortality/aging  nervous system 

    POU3F2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for POU3F2: Pou3f2tm1Tno Pou3f2tm1Rsd
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for POU3F2 

    1177 SABiosciences Target genes for POU3F2 (see first 10):
    A2ML1 AAA1 ABCB8 ABHD10 ABHD4 ABI3BP ABLIM2 ACMSD ACN9 ACPL2
    ACSBG1 ACSM4 ACTR3 ACTR6 ADAL ADAM19 ADAM22 ADAM29 ADAMTS6 ADAT2
    ADCY2 ADH4 AGA AGFG1 AGTPBP1 AHCTF1 AHCYL1 AKR1D1 AKT3 ALDH6A1
    ALDH9A1 ALG1L ALG6 ALKBH1 ALOX5AP AMBN ANAPC5 ANKRA2 ANKRD36 ANLN
    ANXA1 ANXA3 AP1B1 AP1M1 APEX2 APOH ARHGEF6 ARL15 ARL2 ARL2BP
    ARL5A ARL8B ASAH2 ASAP2 ASB18 ASPM ASPN ATF7IP2 ATG5 ATG9B
    ATP1A1 ATP1B2 ATP5A1 ATPAF1 ATPAF2 ATPBD4 AUH B2M B3GALT2 B3GNT5
    B4GALT6 BATF2 BCL10 BCL6B BEND5 BMI1 BOC BRDT BTAF1 C10orf113
    C10orf53 C10orf68 C11orf57 C12orf36 C12orf39 C12orf60 C12orf63 C12orf76 C14orf1 C14orf177
    C14orf28 C14orf37 C15orf61 C16orf62 C16orf87 C17orf49 C17orf74 C18orf54 C1D C1QTNF2
    C1QTNF7 C1orf110 C1orf114 C1orf127 C1orf52 C21orf49 C21orf91 C2CD2 C2orf40 C2orf47
    C2orf70 C2orf73 C3orf14 C3orf17 C3orf49 C3orf65 C4BPA C4orf19 C4orf21 C4orf22
    C4orf47 C5 C5orf47 C5orf50 C6 C6orf118 C7orf25 C7orf45 C7orf66 C8orf49
    C8orf86 C9orf106 C9orf123 C9orf170 C9orf9 CA2 CACNA2D1 CACNA2D4 CAGE1 CALB2
    CALCR CALML5 CALU CANT1 CAPN11 CASZ1 CATSPER3 CATSPER4 CBR3 CBWD1
    CBWD3 CBWD5 CBWD6 CCDC109B CCDC111 CCDC112 CCDC129 CCDC144NL CCDC17 CCDC33
    CCDC50 CCDC66 CCDC73 CCNB3 CCT2 CD200R1L CD24 CD3D CD3G CD5
    CD84 CDC14C CDC20B CDC42EP3 CDH18 CDH20 CDH6 CDKN2AIP CDR2 CDY1B
    CDY2A CDY2B CDYL2 CEP192 CEP97 CHCHD7 CHD8 CHIC1 CHMP2B CHMP4A
    CHN1 CHP2 CHRNA5 CHRNB1 CIB1 CIB3 CIT CKAP2L CLCA1 CLCA3P
    CLEC16A CLEC4A CLECL1 CLLU1 CLLU1OS CLNK CNTN5 CNTNAP2 CNTNAP4 COG1
    COL3A1 COX7C CPVL CREBZF CSGALNACT2 CSH1 CSRNP3 CST9 CTNNA1 CTNNAL1
    CTXN3 CXXC5 CXorf64 CYLC2 CYSLTR2 DAD1 DCBLD2 DCDC1 DCDC5 DCP2
    DDX25 DDX4 DDX50 DEF6 DEFA4 DEFA6 DEFB130 DEFB131 DEFB133 DEFB134
    DENND2C DERA DEXI DGKB DGKQ DHODH DHRS11 DHTKD1 DIRC2 DKFZp686L13185
    DKFZp779M0652 DMRT1 DMRT2 DNAH5 DNAJB8 DNAJC13 DNAJC19 DNAJC24 DNAJC5 DNAJC5G
    DPH5 DPPA3 DPY19L1 DPY30 DPYSL5 DRD3 DSCR4 DTWD2 DUSP14 DUSP15
    DUXA DYNLT1 E2F5 E2F7 ECD EFR3A EGFL6 EID1 EIF2A EIF5A2
    ELOVL5 ENTPD5 EPB41L1 ERAP1 ESAM ETFA EXOC1 EXOSC10 EYS F2RL2
    FAH FAM104B FAM110B FAM110C FAM120C FAM129A FAM135A FAM149B1 FAM151B FAM159B
    FAM160B1 FAM183A FAM183B FAM19A1 FAM20A FAM22D FAM22F FAM22G FAM25A FAM32A
    FAM3D FAM46D FAM47C FAM49A FAM49B FAM53B FAM66A FAM66D FAM69A FAM71F1
    FAM83A FANCG FBXL3 FBXO31 FCHO1 FCRL6 FERD3L FGB FGF11 FGF22
    FGFBP1 FGFBP3 FGFR1OP FICD FLJ12825 FLJ42842 FLJ45256 FLJ45872 FLRT2 FLVCR2
    FMNL2 FMO2 FRAT1 FSCB FSD1 FSHR FYTTD1 GABARAPL2 GABRB2 GABRR2
    GALNT13 GANC GARNL3 GCA GCNT6 GDE1 GEMIN5 GEMIN6 GFRAL GGH
    GIN1 GINS2 GLB1L3 GLCCI1 GLMN GLRA3 GLT8D2 GLUD2 GLYCAM1 GMPR2
    GNGT1 GOLGA8A GON4L GPR1 GPR128 GPR151 GPR173 GPR22 GPR82 GPR85
    GRHL1 GRIA2 GRK7 GRM5 GRM8 GRXCR1 GTF2A2 GTF2E2 GTF2F2 GTF3C2
    GUCY1B2 GUF1 GYPE GZF1 HAL HAUS1 HCFC2 HCRP1 HDC HDHD2
    HERC1 HERC3 HGC6.3 HGFAC HHIP HIATL1 HIATL2 HLTF HOXB1 HOXB2
    HPGD HS2ST1 HS6ST2 HSPA9 HSPBAP1 HTR3C ICA1L IDO2 IDUA IER5
    IFIT1 IFNA21 IFNE IFT57 IGDCC3 IKBKAP IKBKB IL13RA2 IL34 IMPG1
    ING4 INTS4L1 INTS4L2 IP6K2 IPCEF1 IPW IRAK3 IREB2 ISOC1 ITPKA
    JPH1 KBTBD3 KBTBD8 KCMF1 KCNA4 KCNU1 KCNV1 KCTD4 KIAA0196 KIAA0895
    KIAA1211 KIAA1524 KIAA1644 KLC1 KLHL23 KLHL32 KLHL34 KLHL9 KLRB1 KRTAP12-1
    KRTAP12-2 KRTAP13-1 KRTAP13-2 KRTAP19-7 KRTAP20-1 KRTAP20-2 KRTAP20-3 KRTAP20-4 KRTAP6-1 KRTAP6-2
    KRTAP6-3 L3MBTL3 LAMB4 LCA5L LCMT2 LCT LDB2 LDLRAD1 LELP1 LHFPL2
    LIMS2 LIN52 LIPJ LMO1 LMO7 LOC100127983 LOC100128252 LOC100128276 LOC100128386 LOC100128542
    LOC100128714 LOC100129033 LOC100129149 LOC100129321 LOC100129375 LOC100129461 LOC100129527 LOC100129603 LOC100129707 LOC100130015
    LOC100130169 LOC100130176 LOC100130480 LOC100130503 LOC100131254 LOC100131471 LOC100131669 LOC100132319 LOC100132644 LOC100132781
    LOC100132790 LOC100132813 LOC100133267 LOC100133286 LOC100270746 LOC100286931 LOC100286986 LOC100287430 LOC100287590 LOC100287612
    LOC100287651 LOC100287685 LOC100287852 LOC100288067 LOC100288093 LOC100288208 LOC100288379 LOC100288570 LOC100288644 LOC100288974
    LOC100289009 LOC100289347 LOC100289455 LOC100289585 LOC121296 LOC124685 LOC138864 LOC146481 LOC151760 LOC152845
    LOC154872 LOC255167 LOC283440 LOC283588 LOC283867 LOC285627 LOC338797 LOC340268 LOC340508 LOC341378
    LOC344382 LOC345051 LOC387820 LOC388692 LOC388796 LOC388820 LOC389043 LOC389607 LOC389842 LOC390298
    LOC391636 LOC392145 LOC392352 LOC393078 LOC400419 LOC400456 LOC400752 LOC400940 LOC401180 LOC440040
    LOC440895 LOC441242 LOC441454 LOC51145 LOC641367 LOC642935 LOC643733 LOC644090 LOC644456 LOC644684
    LOC644761 LOC645212 LOC645314 LOC646214 LOC646482 LOC646626 LOC646629 LOC646719 LOC646730 LOC647070
    LOC647086 LOC647150 LOC727880 LOC727978 LOC728024 LOC728026 LOC728034 LOC728190 LOC728254 LOC728606
    LOC728715 LOC728755 LOC729141 LOC729574 LOC729587 LOC729817 LOC730101 LOC730236 LOC730268 LOC730441
    LOC730668 LOC730811 LOC730974 LOC732229 LPAL2 LPGAT1 LPPR4 LRP1B LRP2 LRRC2
    LRRC31 LRRC37B LRRC39 LRRIQ1 LRRN3 LSAMP LSM6 LUZP4 LYRM5 LZTFL1
    MACROD2 MAD2L1 MAGEB2 MAGEC3 MAGEF1 MANBA MANEA MAP1B MAP1LC3B2 MAP3K15
    MAP4 MBD5 MBNL3 MBOAT2 MCM8 MCTP1 MDM1 ME3 MED28 METTL14
    MFSD1 MGA MKRN2 MKRN3 MMAA MND1 MORF4 MOV10 MRC1 MRFAP1
    MRGPRX1 MRGPRX4 MRM1 MRPL17 MRPL30 MRPL32 MRPL48 MRPS35 MRTO4 MS4A3
    MS4A6E MTA3 MTERF MTHFD1L MTHFS MTMR6 MTMR7 MTMR9 MUCL1 MUSK
    MYH4 MYL10 MYO3B MYOC N6AMT2 NAPG NBAS NCAN NDST4 NDUFS4
    NEDD8 NEIL2 NEIL3 NEK1 NEO1 NEU2 NFE2L3 NGEF NGFRAP1 NIPAL3
    NIPSNAP3A NIPSNAP3B NKPD1 NKX2-8 NLGN1 NLRC4 NLRP9 NMBR NOL7 NPSR1
    NPTN NR2C2AP NRSN1 NRXN1 NT5DC4 NTM NTN4 NUP37 NUP54 NUPL1
    NXT1 ONECUT3 OR10Q1 OR12D2 OR12D3 OR13C8 OR14I1 OR1D4 OR1D5 OR1E1
    OR2B3 OR2C1 OR2T1 OR2T6 OR4A15 OR4C12 OR4C13 OR4C16 OR4C46 OR4D11
    OR4D9 OR4Q3 OR4X2 OR51B2 OR51B5 OR51B6 OR52R1 OR5H1 OR5J2 OR5M11
    OR5M8 OR6C65 OR6C75 OR6N1 OR8D1 OR8K5 OR9G4 ORAI1 ORMDL2 OTUD6B
    P2RY10 P2RY12 P2RY13 PABPC1L PABPC3 PABPC4L PANX3 PAR1 PARD6G PARVB
    PBX3 PCDH10 PCDHB15 PCDHB19P PCDHGA7 PCDHGB4 PCGEM1 PCYOX1 PDCD11 PDCL2
    PDE10A PDHA2 PDIA5 PER3 PFKFB1 PFKFB3 PGM3 PHACTR2 PHACTR4 PHB
    PHC2 PHF6 PHOSPHO2 PHYH PICALM PIGK PIGU PIH1D2 PIWIL4 PJA1
    PKD1L3 PLA2G4E PLAC1L PLAC8L1 PLAG1 PLCL2 PLD6 PLEKHG7 PLGLA PLGLB1
    PLGLB2 PLOD2 PLRG1 PLSCR4 PNLIPRP1 PNRC2 POLR2J3 POLR3A POLRMT POPDC2
    POTEG POTEH POU2AF1 POU5F1B PPFIBP1 PPID PPP2R2D PRAMEF11 PRKRIR PROK2
    PROKR2 PROSC PRPF38A PRPF38B PRPSAP2 PRR11 PRSS1 PSG2 PSG9 PSMB7
    PSMD3 PSMD6 PSMD7 PSMG1 PSTPIP2 PTPRD PURB PVRL3 RAB11FIP2 RAB19
    RAB1A RAB31 RABL2A RAP1GDS1 RAP2C RASGRP4 RBM15 RBM18 RBM23 RBM44
    RECQL RECQL5 REG1B RERG RERGL RFX6 RGS17 RGS21 RHAG RIMBP3
    RIMBP3B RIMBP3C RIOK1 RIOK2 RIT2 RMND1 RNASEK RNF133 RNF139 RNF145
    RNF148 RNF149 RNFT1 RNLS RNU4-1 RNU4ATAC RNY5 ROPN1L ROR1 RPL31
    RPL37A RPP40 RPS24 RPS6KB1 RSPH4A RSRC1 RUNDC3B RWDD2A S1PR3 SALL3
    SAMSN1 SAP30 SAP30BP SARS SAT1 SCARNA1 SCARNA6 SCG2 SCGB2A2 SCHIP1
    SCN9A SCNN1A SCRG1 SDHD SDK2 SDPR SEC22A SEL1L2 SENP7 SERHL2
    SERP1 SERPINB10 SERPINB3 SERPINB4 SERPIND1 SERPINE3 SESN1 SFMBT1 SFT2D3 SGCD
    SGK196 SGOL2 SHC3 SHH SHOX2 SIAH3 SIGLEC1 SIRT4 SKCG-1 SLAMF6
    SLC10A6 SLC11A1 SLC16A13 SLC25A30 SLC25A4 SLC2A10 SLC37A3 SLC38A1 SLC39A12 SLC39A2
    SLC44A1 SLC45A3 SLC4A10 SLC4A4 SLC6A13 SLC6A4 SLCO1B1 SLCO1B3 SMARCE1 SNAPC1
    SNHG11 SNORA39 SNORA46 SNORA50 SNORA60 SNORA71A SNORA71B SNORA71C SNORA71D SNORD113-4
    SNORD113-5 SNORD113-6 SNORD113-7 SNORD113-8 SNORD113-9 SNORD114-1 SNORD114-2 SNORD114-3 SNORD114-4 SNORD114-5
    SNORD114-6 SNORD116-11 SNORD116-12 SNORD116-14 SNORD116-15 SNORD116-16 SNORD116-17 SNORD116-18 SNORD116-19 SNORD116-20
    SNORD116-21 SNORD116-22 SNORD116-23 SNORD116-3 SNORD116-4 SNORD116-5 SNORD116-6 SNORD116-7 SNORD116-8 SNORD94
    SNRNP40 SNTB2 SNX10 SNX14 SOCS4 SOCS6 SORCS1 SPACA1 SPACA3 SPACA5B
    SPANXD SPANXN2 SPATA4 SPEM1 SPOCK2 SPON1 SRP19 SSRP1 SSTR1 SSX1
    SSX10 SSX2IP ST13 ST6GALNAC3 STAG1 STARD6 STOX2 STRA6 STT3B SUCLG2
    SUCNR1 SYT11 SYTL1 SYTL3 TACR3 TAF7L TARSL2 TAS2R41 TAS2R5 TBC1D14
    TBC1D21 TBC1D26 TBC1D4 TBCA TBKBP1 TCERG1L TCL1B TCN1 TDGF1 TEX10
    TFDP1 TFPI2 THBD THOC1 THUMPD2 TIA1 TIAF1 TIMM44 TIMM8A TIMM8B
    TINF2 TLR10 TM2D2 TM2D3 TMCC1 TMCO5A TMEM102 TMEM132C TMEM170A TMEM209
    TMEM220 TMEM222 TMEM30B TMEM87A TMIGD2 TMPRSS4 TMSB15A TNFSF4 TNRC6A TPH2
    TPMT TPRG1 TRA2B TRAM1L1 TRDN TRIM54 TRMT6 TRPM3 TRPV4 TSGA10
    TSGA13 TSHB TSPAN12 TSPAN18 TSPAN19 TSPAN2 TSPY1 TSPY3 TSPYL4 TTF1
    TTLL13 TTLL5 TTLL9 TTTY20 TTTY6B TTTY8 TUBA8 TUBD1 TUBGCP5 TUSC3
    UBE4A UBQLN2 UCN3 UFSP2 UGCG URB2 USMG5 USP46 USP53 USPL1
    UTP15 UTS2D VAMP3 VANGL1 VCP VENTXP1 VGLL3 VPS13C VPS4B VSIG2
    WARS2 WBP11 WDR64 WDR75 WIPF2 WIPI1 WNT5A WSCD1 WTIP XAGE1A
    XAGE1B XAGE1C XAGE1E XCL1 XCR1 XKRX XPO5 YIPF4 YIPF7 ZBED4
    ZBTB24 ZCCHC7 ZCWPW2 ZDHHC11B ZDHHC23 ZFP30 ZFPM2 ZFYVE1 ZFYVE26 ZMAT1
    ZMYND11 ZNF18 ZNF264 ZNF347 ZNF407 ZNF425 ZNF471 ZNF485 ZNF551 ZNF667
    ZNF705D ZNF709 ZNF720 ZNF782 ZNF821 ZPBP ZSCAN4

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neuroscience
    Neuroscience1.00
    2Transcription factors in neurogenesis
    Transcription factors in neurogenesis1.00
    3SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for POU3F2
        Transcription factors in neurogenesis


    1 Cell Signaling Technology (CST) Pathway for POU3F2
        Neuroscience

    1 BioSystems Pathway for POU3F2 
        SIDS Susceptibility Pathways



    POU3F2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU3F2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/12 Interacting proteins for POU3F2 (P202651, 2, 3 ENSP000003291704) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBPP202261, 3, ENSP000002303544EBI-1167176,EBI-1056192 I2D: score=3 STRING: ENSP00000230354
    PAX3P237601, 3, ENSP000003759214EBI-1167176,EBI-1167564 I2D: score=2 STRING: ENSP00000375921
    SOX10P566931, 3, ENSP000003541304EBI-1167176,EBI-1167533 I2D: score=3 STRING: ENSP00000354130
    EP300Q094721, 3, ENSP000002632534EBI-1167176,EBI-3908041 I2D: score=2 STRING: ENSP00000263253
    SOX11P357163, ENSP000003225684I2D: score=1 STRING: ENSP00000322568
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0008284positive regulation of cell proliferation IDA15024079
    GO:0008544epidermis development IEA--
    GO:0014002astrocyte development IEA--

    POU3F2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POU3F2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for POU3F2
    2 Novoseek chemical compound relationships for POU3F2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    l-amino acid 52.7 1 11311976 (1)
    oligonucleotide 5.21 2 8026890 (1), 9852081 (1)

    Search CenterWatch for drugs/clinical trials and news about POU3F2 / PO3F2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POU3F2 gene: 
    NM_005604.3  

    Unigene Cluster for POU3F2:

    POU class 3 homeobox 2
    Hs.182505  [show with all ESTs]
    Unigene Representative Sequence: BC051699
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000328345(uc003ppe.3)

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    Additional cDNA sequence: 

    AK095588.1 BC051699.1 Z11933.1 

    2 DOTS entries:

    DT.436597  DT.102820716 

    24 AceView cDNA sequences:

    Z46167 BQ423615 BE855760 AL119023 F08761 NM_005604 BF983322 F05048 
    Z41794 BC051699 BX645336 D55919 F02230 Z11933 BU183021 BE765714 
    AI655029 BI914245 AW054773 F05989 BF978474 AL138356 AL708299 C15289 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU3F2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    POU3F2 Expression
    About this image
    See POU3F2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POU3F2

    SOURCE GeneReport for Unigene cluster: Hs.182505

    UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265
    Tissue specificity: Expressed specifically in the neuroectodermal cell lineage

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for POU3F2 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia POU3F26
    --
    74(a)
    1 ↔ 1
    1(172183708-172184733)
    African clawed frog
    (Xenopus laevis)
    Amphibia pou3f2-A2 POU domain, class 3, transcription factor 2 80.67(n)    BC041298.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pou472 POU domain gene 47 82.95(n)   30397  NM_131160.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vvl3 peripheral nervous system development DNA
    binding
    94(a)
    (best of 3)
      3 65C5   --
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-63 Homeobox domain, Pou domain - N-terminal to
    homeobox more
    69(a)   I(8506480-8510320)   --


    ENSEMBL Gene Tree for POU3F2 (if available)
    TreeFam Gene Tree for POU3F2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POU3F2 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F42  POU3F12  POU1F12  POU4F32  
    POU3F32  POU2F22  POU5F1B2  POU2F12  POU4F12  POU5F12  POU6F12  
    14 SIMAP similar genes for POU3F2 using alignment to 1 protein entry:     PO3F2_HUMAN:
    POU6F1    POU3F4    POU1F1    POU4F3    POU5F1P4    POU3F3
    POU5F1    POU2F3    POU3F1    POU5F1P1    POU2F1    POU5F1B
    POU2F2    POU4F2

    POU3F2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/77 NCBI SNPs in POU3F2 are shown (see all 77    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402400611,2
    --99280593(+) CGCGGA/GTGCGC 1 -- us2k10--------
    rs132091381,2
    C,F--99280657(+) CCTATC/TCATTT 1 -- us2k15Minor allele frequency- T:0.29NA EA 246
    rs1144266991,2
    F--99280768(+) AGCCAC/GTCTCC 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1857333321,2
    --99280874(+) CTGAGC/GGTTGA 1 -- us2k10--------
    rs93729561,2
    --99280951(+) GGACGC/TGATCC 1 -- us2k10--------
    rs1911481251,2
    --99281157(+) CGACGC/TGCCCG 1 -- us2k10--------
    rs1451985751,2
    --99281292(+) GCCCAC/TCGAAG 1 -- us2k10--------
    rs119688221,2
    C,A,H--99281393(+) CCAGCG/TGTAGG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1169993811,2
    F--99281405(+) GCACGG/AGGAAT 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs132091541,2
    C--99281407(+) ACGGGC/GAATCG 1 -- us2k12Minor allele frequency- G:0.25NA 4

    HapMap Linkage Disequilibrium report for POU3F2 (99282580 - 99286666 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for POU3F2
         2 CNVs: 81507 93909

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    POU3F2 for disorders           About GeneDecksing

    OMIM gene information: 600494    OMIM disorders: --

    11 diseases for POU3F2:    About MalaCards
    melanoma    merkel cell carcinoma    microphthalmia    neuronitis
    embryonal carcinoma    retinoblastoma    glioblastoma    carcinoma
    cerebritis    neuroblastoma    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for POU3F2:
    Melanoma

    3 Novoseek disease relationships for POU3F2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 61.8 33 18923447 (5), 7651733 (4), 18781132 (3), 15024080 (3) (see all 12)
    microphthalmia 50.2 2 7651733 (1), 7478537 (1)
    tumors 0 3 18781132 (1), 18829533 (1), 7651733 (1)

    Human Genome Epidemiology (HuGE) Navigator: POU3F2 (2 documents)

    Export disorders for POU3F2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU3F2 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with POU3F2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif. (PubMed id 8441633)1, 2, 3 Schreiber E.... Fontana A. (1993)
    2. The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells. (PubMed id 7651733)1, 2, 9 Angus J.... Sturm R.A. (1995)
    3. PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival. (PubMed id 10332029)1, 2, 9 Waragai M.... Okazawa H. (1999)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Expression of a large family of POU-domain regulatory genes in mammalian brain development. (PubMed id 2739723)1, 2 He X....Rosenfeld M.G. (1989)
    7. Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16. (PubMed id 7601453)1, 9 Atanasoski S....Fontana A. (1995)
    8. SOX9 and SOX10 but not BRN2 are required for nestin expression in human melanoma cells. (PubMed id 18923447)1, 9 Flammiger A....Berking C. (2009)
    9. The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development. (PubMed id 12782656)1, 9 Jaegle M....Meijer D. (2003)
    10. The Brn-2 transcription factor links activated BRAF to melanoma proliferation. (PubMed id 15024080)1, 9 Goodall J....Goding C.R. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5454 HGNC: 9215 AceView: POU3F2 Ensembl:ENSG00000184486 euGenes: HUgn5454
    ECgene: POU3F2 H-InvDB: POU3F2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POU3F2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POU3F2 gene:
    Search GeneIP for patents involving POU3F2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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