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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU3F2 Gene

protein-coding   GIFtS: 60
GCID: GC06P099295

POU Class 3 Homeobox 2

(Previous names: POU domain class 3, transcription factor 2)
(Previous symbol: OTF7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
POU Class 3 Homeobox 21 2     N-Oct32
OTF71 2 3     POUF32
OCT72 3 5     brain-22
Brain-Specific Homeobox/POU Domain Protein 22 3     brn-22
Nervous System-Specific Octamer-Binding Transcription Factor N-Oct-32 3     oct-72
Octamer-Binding Protein 72 3     POU Domain, Class 3, Transcription Factor 22
Octamer-Binding Transcription Factor 72 3     Brain-23
BRN22 3     Brn-23
OTF-72 3     Oct-73
POU Domain Class 3, Transcription Factor 21     

External Ids:    HGNC: 92151   Entrez Gene: 54542   Ensembl: ENSG000001844867   OMIM: 6004945   UniProtKB: P202653   

Export aliases for POU3F2 gene to outside databases

Previous GC identifers: GC06P099150 GC06P099299 GC06P099328 GC06P099389 GC06P096721


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POU3F2 Gene:
This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved
in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes.
Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. (provided
by RefSeq, Mar 2012)

GeneCards Summary for POU3F2 Gene: 
POU3F2 (POU class 3 homeobox 2) is a protein-coding gene. Diseases associated with POU3F2 include merkel cell carcinoma, and microphthalmia. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265
Function: Transcription factor that binds preferentially to the recognition sequence which consists of two
distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides.
Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters
(By similarity)

Gene Wiki entry for POU3F2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU3F2 gene promoter:
         TBP   AhR   C/EBPbeta   Pax-5   Tal-1   FOXD3   Arnt   E47   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOU3F2 promoter sequence
   Search SABiosciences Chromatin IP Primers for POU3F2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU3F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16   Ensembl cytogenetic band:  6q16.1   HGNC cytogenetic band: 6q16.2

POU3F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU3F2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P099295:  view genomic region     (about GC identifiers)

Start:
99,282,580 bp from pter      End:
99,286,666 bp from pter
Size:
4,087 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265 (See protein sequence)
Recommended Name: POU domain, class 3, transcription factor 2  
Size: 443 amino acids; 46893 Da
Subunit: Interacts with PQBP1
Subcellular location: Nucleus
Secondary accessions: Q14960 Q86V54 Q9UJL0
Alternative initiation: 3 isoforms:  P20265-1   P20265-2   P20265-3   

Explore the universe of human proteins at neXtProt for POU3F2: NX_P20265

Explore proteomics data for POU3F2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20265

  • POU3F2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    POU3F2 Protein Expression
    REFSEQ proteins: NP_005595.2  
    ENSEMBL proteins: 
     ENSP00000329170  

    Human Recombinant Protein Products for POU3F2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for POU3F2
    OriGene Protein Over-expression Lysate for POU3F2
    OriGene MassSpec for POU3F2 
    OriGene Custom Protein Services for POU3F2
    GenScript Custom Purified and Recombinant Proteins Services for POU3F2
    Novus Biologicals POU3F2 Proteins
    Novus Biologicals POU3F2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--

    POU3F2 for ontologies           About GeneDecksing



    POU3F2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of POU3F2
    R&D Systems Antibodies for POU3F2
    Cell Signaling Technology (CST) Antibodies for POU3F2  (7-Oct)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for POU3F2
    GenScript Custom Superior Antibodies Services for POU3F2
    Novus Biologicals POU3F2 Antibodies
    Abcam antibodies for POU3F2
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for POU3F2
    LSBio Antibodies in human, mouse, rat for POU3F2 

    Assay Products for POU3F2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for POU3F2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POU3F2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    POU: Homeoboxes / POU class

    5/7 InterPro protein domains (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR016362 Transcription_factor_POU
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS

    Graphical View of Domain Structure for InterPro Entry P20265

    ProtoNet protein and cluster: P20265

    2 Blocks protein domains:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265
    Similarity: Belongs to the POU transcription factor family. Class-3 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    POU3F2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO3F2_HUMAN, P20265
    Function: Transcription factor that binds preferentially to the recognition sequence which consists of two
    distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides.
    Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters
    (By similarity)

         Genatlas biochemistry entry for POU3F2:
    POU domain,class 3,transcription factor 2,murine brain-2 (Brn-2) homolog

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001105RNA polymerase II transcription coactivator activity IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI11029584
    GO:0042802identical protein binding IPI11029584
         
    POU3F2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for POU3F2:
     Decreased Hepatitis C virus re 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pou3f2):
     adipose tissue  cellular  endocrine/exocrine gland  growth/size  integument 
     liver/biliary system  mortality/aging  nervous system 

    POU3F2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for POU3F2: Pou3f2tm1Tno Pou3f2tm1Rsd

       inGenious Targeting Laboratory - Custom generated mouse model solutions for POU3F2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POU3F2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU3F2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU3F2 

    1150 SABiosciences Target genes for POU3F2 (see first 10):
    A2ML1 AAA1 ABCB8 ABHD10 ABHD4 ABI3BP ABLIM2 ACMSD ACN9 ACPL2
    ACSBG1 ACSM4 ACTR3 ACTR6 ADAL ADAM19 ADAM22 ADAM29 ADAMTS6 ADAT2
    ADCY2 ADH4 AGA AGFG1 AGTPBP1 AHCTF1 AHCYL1 AKR1D1 AKT3 ALDH6A1
    ALDH9A1 ALG1L ALG6 ALKBH1 ALOX5AP AMBN ANAPC5 ANKRA2 ANKRD36 ANLN
    ANXA1 ANXA3 AP1B1 AP1M1 APEX2 APOH ARHGEF6 ARL15 ARL2 ARL2BP
    ARL5A ARL8B ASAH2 ASAP2 ASB18 ASPM ASPN ATF7IP2 ATG5 ATG9B
    ATP1A1 ATP1B2 ATP5A1 ATPAF1 ATPAF2 AUH B2M B3GALT2 B3GNT5 B4GALT6
    BATF2 BCL10 BCL6B BEND5 BMI1 BOC BRDT BTAF1 C10orf113 C10orf53
    C10orf68 C11orf57 C12orf36 C12orf39 C12orf60 C12orf63 C12orf76 C14orf1 C14orf177 C14orf28
    C14orf37 C15orf61 C16orf62 C16orf87 C17orf49 C17orf74 C18orf54 C1D C1QTNF2 C1QTNF7
    C1orf110 C1orf127 C1orf52 C21orf49 C21orf91 C2CD2 C2orf40 C2orf47 C2orf70 C2orf73
    C3orf14 C3orf17 C3orf49 C3orf65 C4BPA C4orf19 C4orf21 C4orf22 C4orf47 C5
    C5orf47 C5orf50 C6 C6orf118 C7orf25 C7orf66 C8orf49 C8orf86 C9orf106 C9orf170
    C9orf9 CA2 CACNA2D1 CACNA2D4 CAGE1 CALB2 CALCR CALML5 CALU CANT1
    CAPN11 CASZ1 CATSPER3 CATSPER4 CBR3 CBWD1 CBWD3 CBWD5 CBWD6 CCDC109B
    CCDC112 CCDC129 CCDC144NL CCDC17 CCDC33 CCDC50 CCDC66 CCDC73 CCNB3 CCT2
    CD200R1L CD24 CD3D CD3G CD5 CD84 CDC14C CDC20B CDC42EP3 CDH18
    CDH20 CDH6 CDKN2AIP CDR2 CDY1B CDY2A CDY2B CDYL2 CEP192 CEP97
    CHCHD7 CHD8 CHIC1 CHMP2B CHMP4A CHN1 CHP2 CHRNA5 CHRNB1 CIB1
    CIB3 CIT CKAP2L CLCA1 CLCA3P CLEC16A CLEC4A CLECL1 CLLU1 CLLU1OS
    CLNK CNTN5 CNTNAP2 CNTNAP4 COG1 COL3A1 COX7C CPVL CREBZF CSGALNACT2
    CSH1 CSRNP3 CST9 CTNNA1 CTNNAL1 CTXN3 CXXC5 CXorf64 CYLC2 CYSLTR2
    DAD1 DCBLD2 DCDC1 DCDC5 DCP2 DDX25 DDX4 DDX50 DEF6 DEFA4
    DEFA6 DEFB130 DEFB131 DEFB133 DEFB134 DENND2C DERA DEXI DGKB DGKQ
    DHODH DHRS11 DHTKD1 DIRC2 DKFZp686L13185 DKFZp779M0652 DMRT1 DMRT2 DNAH5 DNAJB8
    DNAJC13 DNAJC19 DNAJC24 DNAJC5 DNAJC5G DPH5 DPPA3 DPY19L1 DPY30 DPYSL5
    DRD3 DSCR4 DTWD2 DUSP14 DUSP15 DUXA DYNLT1 E2F5 E2F7 ECD
    EFR3A EGFL6 EID1 EIF2A EIF5A2 ELOVL5 ENTPD5 EPB41L1 ERAP1 ESAM
    ETFA EXOC1 EXOSC10 EYS F2RL2 FAH FAM104B FAM110B FAM110C FAM120C
    FAM129A FAM135A FAM149B1 FAM151B FAM159B FAM160B1 FAM183A FAM183B FAM19A1 FAM20A
    FAM25A FAM32A FAM3D FAM46D FAM47C FAM49A FAM49B FAM53B FAM66A FAM66D
    FAM69A FAM71F1 FAM83A FANCG FBXL3 FBXO31 FCHO1 FCRL6 FERD3L FGB
    FGF11 FGF22 FGFBP1 FGFBP3 FGFR1OP FICD FLJ12825 FLJ42842 FLJ45256 FLJ45872
    FLRT2 FLVCR2 FMNL2 FMO2 FRAT1 FSCB FSD1 FSHR FYTTD1 GABARAPL2
    GABRB2 GABRR2 GALNT13 GANC GARNL3 GCA GCNT6 GDE1 GEMIN5 GEMIN6
    GFRAL GGH GIN1 GINS2 GLB1L3 GLCCI1 GLMN GLRA3 GLT8D2 GLUD2
    GLYCAM1 GMPR2 GNGT1 GOLGA8A GON4L GPR1 GPR128 GPR151 GPR173 GPR22
    GPR82 GPR85 GRHL1 GRIA2 GRK7 GRM5 GRM8 GRXCR1 GTF2A2 GTF2E2
    GTF2F2 GTF3C2 GUCY1B2 GUF1 GYPE GZF1 HAL HAUS1 HCFC2 HCRP1
    HDC HDHD2 HERC1 HERC3 HGC6.3 HGFAC HHIP HIATL1 HIATL2 HLTF
    HOXB1 HOXB2 HPGD HS2ST1 HS6ST2 HSPA9 HSPBAP1 HTR3C ICA1L IDO2
    IDUA IER5 IFIT1 IFNA21 IFNE IFT57 IGDCC3 IKBKAP IKBKB IL13RA2
    IL34 IMPG1 ING4 INTS4L1 INTS4L2 IP6K2 IPCEF1 IPW IRAK3 IREB2
    ISOC1 ITPKA JPH1 KBTBD3 KBTBD8 KCMF1 KCNA4 KCNU1 KCNV1 KCTD4
    KIAA0196 KIAA0895 KIAA1211 KIAA1524 KIAA1644 KLC1 KLHL23 KLHL32 KLHL34 KLHL9
    KLRB1 KRTAP12-1 KRTAP12-2 KRTAP13-1 KRTAP13-2 KRTAP19-7 KRTAP20-1 KRTAP20-2 KRTAP20-3 KRTAP20-4
    KRTAP6-1 KRTAP6-2 KRTAP6-3 L3MBTL3 LAMB4 LCA5L LCMT2 LCT LDB2 LDLRAD1
    LELP1 LHFPL2 LIMS2 LIN52 LIPJ LMO1 LMO7 LOC100127983 LOC100128276 LOC100128386
    LOC100128542 LOC100128714 LOC100129033 LOC100129149 LOC100129321 LOC100129375 LOC100129461 LOC100129527 LOC100129603 LOC100129707
    LOC100130169 LOC100130176 LOC100130480 LOC100130503 LOC100131254 LOC100131471 LOC100131669 LOC100132319 LOC100132644 LOC100132781
    LOC100132790 LOC100132813 LOC100133267 LOC100133286 LOC100270746 LOC100286986 LOC100287430 LOC100287590 LOC100287651 LOC100287685
    LOC100287852 LOC100288093 LOC100288208 LOC100288379 LOC100288570 LOC100288644 LOC100288974 LOC100289009 LOC100289347 LOC100289455
    LOC100289585 LOC121296 LOC124685 LOC138864 LOC146481 LOC151760 LOC152845 LOC154872 LOC283440 LOC283588
    LOC285627 LOC338797 LOC340268 LOC340508 LOC341378 LOC344382 LOC345051 LOC387820 LOC388692 LOC388820
    LOC389043 LOC389607 LOC389842 LOC390298 LOC391636 LOC392145 LOC392352 LOC393078 LOC400419 LOC400456
    LOC400752 LOC400940 LOC440040 LOC440895 LOC441242 LOC441454 LOC51145 LOC641367 LOC642935 LOC643733
    LOC644090 LOC644456 LOC645314 LOC646214 LOC646482 LOC646626 LOC646629 LOC646719 LOC646730 LOC647070
    LOC647086 LOC647150 LOC727880 LOC727978 LOC728024 LOC728026 LOC728254 LOC728606 LOC728715 LOC728755
    LOC729141 LOC729574 LOC729587 LOC730101 LOC730236 LOC730268 LOC730441 LOC730668 LOC730811 LOC730974
    LOC732229 LPAL2 LPGAT1 LPPR4 LRP1B LRP2 LRRC2 LRRC31 LRRC37B LRRC39
    LRRIQ1 LRRN3 LSAMP LSM6 LUZP4 LYRM5 LZTFL1 MACROD2 MAD2L1 MAGEB2
    MAGEC3 MAGEF1 MANBA MANEA MAP1B MAP1LC3B2 MAP3K15 MAP4 MBD5 MBNL3
    MBOAT2 MCM8 MCTP1 MDM1 ME3 MED28 METTL14 MFSD1 MGA MKRN2
    MKRN3 MMAA MND1 MORF4 MOV10 MRC1 MRFAP1 MRGPRX1 MRGPRX4 MRM1
    MRPL17 MRPL30 MRPL32 MRPL48 MRPS35 MRTO4 MS4A3 MS4A6E MTA3 MTERF
    MTHFD1L MTHFS MTMR6 MTMR7 MTMR9 MUCL1 MUSK MYH4 MYL10 MYO3B
    MYOC N6AMT2 NAPG NBAS NCAN NDST4 NDUFS4 NEDD8 NEIL2 NEIL3
    NEK1 NEO1 NEU2 NFE2L3 NGEF NGFRAP1 NIPAL3 NIPSNAP3A NIPSNAP3B NKPD1
    NKX2-8 NLGN1 NLRC4 NLRP9 NMBR NOL7 NPSR1 NPTN NR2C2AP NRSN1
    NRXN1 NT5DC4 NTM NTN4 NUP37 NUP54 NUPL1 NXT1 ONECUT3 OR10Q1
    OR12D2 OR12D3 OR13C8 OR14I1 OR1D4 OR1D5 OR1E1 OR2B3 OR2C1 OR2T1
    OR2T6 OR4A15 OR4C12 OR4C13 OR4C16 OR4C46 OR4D11 OR4D9 OR4Q3 OR4X2
    OR51B2 OR51B5 OR51B6 OR52R1 OR5H1 OR5J2 OR5M11 OR5M8 OR6C65 OR6C75
    OR6N1 OR8D1 OR8K5 OR9G4 ORAI1 ORMDL2 OTUD6B P2RY10 P2RY12 P2RY13
    PABPC1L PABPC3 PABPC4L PANX3 PARD6G PARVB PBX3 PCDH10 PCDHB15 PCDHB19P
    PCDHGA7 PCDHGB4 PCGEM1 PCYOX1 PDCD11 PDCL2 PDE10A PDHA2 PDIA5 PER3
    PFKFB1 PFKFB3 PGM3 PHACTR2 PHACTR4 PHB PHC2 PHF6 PHOSPHO2 PHYH
    PICALM PIGK PIGU PIH1D2 PIWIL4 PJA1 PKD1L3 PLA2G4E PLAC1L PLAC8L1
    PLAG1 PLCL2 PLD6 PLEKHG7 PLGLA PLGLB1 PLGLB2 PLOD2 PLRG1 PLSCR4
    PNLIPRP1 PNRC2 POLR2J3 POLR3A POLRMT POPDC2 POTEG POTEH POU2AF1 POU5F1B
    PPFIBP1 PPID PPP2R2D PRAMEF11 PRKRIR PROK2 PROKR2 PROSC PRPF38A PRPF38B
    PRPSAP2 PRR11 PRSS1 PSG2 PSG9 PSMB7 PSMD3 PSMD6 PSMD7 PSMG1
    PSTPIP2 PTPRD PURB PVRL3 RAB11FIP2 RAB19 RAB1A RAB31 RABL2A RAP1GDS1
    RAP2C RASGRP4 RBM15 RBM18 RBM23 RBM44 RECQL RECQL5 REG1B RERG
    RERGL RFX6 RGS17 RGS21 RHAG RIMBP3 RIMBP3B RIMBP3C RIOK1 RIOK2
    RIT2 RMND1 RNASEK RNF133 RNF139 RNF145 RNF148 RNF149 RNFT1 RNLS
    RNU4-1 RNU4ATAC RNY5 ROPN1L ROR1 RPL31 RPL37A RPP40 RPS24 RPS6KB1
    RSPH4A RSRC1 RUNDC3B RWDD2A S1PR3 SALL3 SAMSN1 SAP30 SAP30BP SARS
    SAT1 SCARNA1 SCARNA6 SCG2 SCGB2A2 SCHIP1 SCN9A SCNN1A SCRG1 SDHD
    SDK2 SDPR SEC22A SEL1L2 SENP7 SERHL2 SERP1 SERPINB10 SERPINB3 SERPINB4
    SERPIND1 SERPINE3 SESN1 SFMBT1 SFT2D3 SGCD SGOL2 SHC3 SHH SHOX2
    SIAH3 SIGLEC1 SIRT4 SKCG-1 SLAMF6 SLC10A6 SLC11A1 SLC16A13 SLC25A30 SLC25A4
    SLC2A10 SLC37A3 SLC38A1 SLC39A12 SLC39A2 SLC44A1 SLC45A3 SLC4A10 SLC4A4 SLC6A13
    SLC6A4 SLCO1B1 SLCO1B3 SMARCE1 SNAPC1 SNHG11 SNORA39 SNORA46 SNORA50 SNORA60
    SNORA71A SNORA71B SNORA71C SNORA71D SNORD113-4 SNORD113-5 SNORD113-6 SNORD113-7 SNORD113-8 SNORD113-9
    SNORD114-1 SNORD114-2 SNORD114-3 SNORD114-4 SNORD114-5 SNORD114-6 SNORD116-11 SNORD116-12 SNORD116-14 SNORD116-15
    SNORD116-16 SNORD116-17 SNORD116-18 SNORD116-19 SNORD116-20 SNORD116-21 SNORD116-22 SNORD116-23 SNORD116-3 SNORD116-4
    SNORD116-5 SNORD116-6 SNORD116-7 SNORD116-8 SNORD94 SNRNP40 SNTB2 SNX10 SNX14 SOCS4
    SOCS6 SORCS1 SPACA1 SPACA3 SPACA5B SPANXD SPANXN2 SPATA4 SPEM1 SPOCK2
    SPON1 SRP19 SSRP1 SSTR1 SSX1 SSX2IP ST13 ST6GALNAC3 STAG1 STARD6
    STOX2 STRA6 STT3B SUCLG2 SUCNR1 SYT11 SYTL1 SYTL3 TACR3 TAF7L
    TARSL2 TAS2R41 TAS2R5 TBC1D14 TBC1D21 TBC1D26 TBC1D4 TBCA TBKBP1 TCERG1L
    TCL1B TCN1 TDGF1 TEX10 TFDP1 TFPI2 THBD THOC1 THUMPD2 TIA1
    TIAF1 TIMM44 TIMM8A TIMM8B TINF2 TLR10 TM2D2 TM2D3 TMCC1 TMCO5A
    TMEM102 TMEM132C TMEM170A TMEM209 TMEM220 TMEM222 TMEM30B TMEM87A TMIGD2 TMPRSS4
    TMSB15A TNFSF4 TNRC6A TPH2 TPMT TPRG1 TRA2B TRAM1L1 TRDN TRIM54
    TRMT6 TRPM3 TRPV4 TSGA10 TSGA13 TSHB TSPAN12 TSPAN18 TSPAN19 TSPAN2
    TSPY1 TSPY3 TSPYL4 TTF1 TTLL13 TTLL5 TTLL9 TTTY20 TTTY6B TTTY8
    TUBA8 TUBD1 TUBGCP5 TUSC3 UBE4A UBQLN2 UCN3 UFSP2 UGCG URB2
    USMG5 USP46 USP53 USPL1 UTP15 VAMP3 VANGL1 VCP VENTXP1 VGLL3
    VPS13C VPS4B VSIG2 WARS2 WBP11 WDR64 WDR75 WIPF2 WIPI1 WNT5A
    WSCD1 WTIP XAGE1A XAGE1B XAGE1C XAGE1E XCL1 XCR1 XKRX XPO5
    YIPF4 YIPF7 ZBED4 ZBTB24 ZCCHC7 ZCWPW2 ZDHHC11B ZDHHC23 ZFP30 ZFPM2
    ZFYVE1 ZFYVE26 ZMAT1 ZMYND11 ZNF18 ZNF264 ZNF347 ZNF407 ZNF425 ZNF471
    ZNF485 ZNF551 ZNF667 ZNF705D ZNF709 ZNF720 ZNF782 ZNF821 ZPBP ZSCAN4

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for POU3F2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcription factors in neurogenesis
    Transcription factors in neurogenesis
    2Neuroscience
    Neuroscience
    3SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for POU3F2
        Transcription factors in neurogenesis


    1 Cell Signaling Technology (CST) Pathway for POU3F2
        Neuroscience

    1 BioSystems Pathway for POU3F2
        SIDS Susceptibility Pathways



    POU3F2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU3F2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/12 Interacting proteins for POU3F2 (P202651, 2, 3 ENSP000003291704) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBPP202261, 3, ENSP000002303544EBI-1167176,EBI-355371 I2D: score=3 STRING: ENSP00000230354
    PAX3P237601, 3, ENSP000003759214EBI-1167176,EBI-1167564 I2D: score=2 STRING: ENSP00000375921
    SOX10P566931, 3, ENSP000003541304EBI-1167176,EBI-1167533 I2D: score=3 STRING: ENSP00000354130
    EP300Q094721, 3, ENSP000002632534EBI-1167176,EBI-447295 I2D: score=2 STRING: ENSP00000263253
    SOX11P357163, ENSP000003225684I2D: score=1 STRING: ENSP00000322568
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0008284positive regulation of cell proliferation IDA15024079
    GO:0008544epidermis development IEA--
    GO:0014002astrocyte development IEA--

    POU3F2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POU3F2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POU3F2 (PO3F2)

    2 Novoseek inferred chemical compound relationships for POU3F2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    l-amino acid 52.7 1 11311976 (1)
    oligonucleotide 5.21 2 8026890 (1), 9852081 (1)

    Search CenterWatch for drugs/clinical trials and news about POU3F2 / PO3F2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POU3F2 gene: 
    NM_005604.3  

    Unigene Cluster for POU3F2:

    POU class 3 homeobox 2
    Hs.182505  [show with all ESTs]
    Unigene Representative Sequence: BC051699
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000328345(uc003ppe.3)
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    Additional mRNA sequence: 

    AK095588.1 BC051699.1 Z11933.1 

    2 DOTS entries:

    DT.436597  DT.102820716 

    24 AceView cDNA sequences:

    AL119023 NM_005604 BE855760 BF983322 Z46167 F05048 F08761 BQ423615 
    Z41794 BC051699 BX645336 BE765714 F02230 Z11933 D55919 BU183021 
    BI914245 AW054773 AI655029 C15289 AL708299 F05989 AL138356 BF978474 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU3F2 expression in normal human tissues (normalized intensities)      POU3F2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    POU3F2 Expression
    About this image


    POU3F2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             Human Astrocytes   
             cortex   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Pro-myelinating Schwann Cells Peripheral Nerve Domain
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Neuron (Nervous System)    fully expand to see all 2 entries
             Human Neurons   
     
     Eye (Sensory Organs)
             sensory organ/eye/cornea   

    See POU3F2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POU3F2

    SOURCE GeneReport for Unigene cluster: Hs.182505

    UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265
    Tissue specificity: Expressed specifically in the neuroectodermal cell lineage

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for POU3F2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou3f21 , 5 POU domain, class 3, transcription factor 21, 5 93.75(n)1
    100(a)1
      4 (9.73 cM)5
    189921  NM_008899.21  NP_032925.11 
     224866445 
    lizard
    (Anolis carolinensis)
    Reptilia POU3F26
    Uncharacterized protein
    76(a)
    1 ↔ 1
    1(172183708-172184733)
    African clawed frog
    (Xenopus laevis)
    Amphibia pou3f2-A2 POU domain, class 3, transcription factor 2 80.67(n)    BC041298.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pou472 POU domain gene 47 82.95(n)   30397  NM_131160.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vvl3 peripheral nervous system development
    DNA binding
    94(a)
    (best of 3)
      3 65C5   --
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-63 Homeobox domain, Pou domain -
    N-terminal to homeobox more
    69(a)   I(8506480-8510320)   --


    ENSEMBL Gene Tree for POU3F2 (if available)
    TreeFam Gene Tree for POU3F2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POU3F2 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F12  POU3F42  POU1F12  POU3F32  
    POU4F32  POU2F22  POU5F1B2  POU4F12  POU2F12  POU6F12  POU5F12  
    13 SIMAP similar genes for POU3F2 using alignment to 1 protein entry:     PO3F2_HUMAN:
    POU6F1    POU3F4    POU1F1    POU4F3    POU5F1P4    POU3F3
    POU5F1    POU2F3    POU3F1    POU5F1P1    POU2F1    POU5F1B
    POU2F2

    POU3F2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/98 SNPs in POU3F2 are shown (see all 98)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402400611,2
    --99280593(+) CGCGGA/GTGCGC 1 -- us2k10--------
    rs132091381,2
    C,F--99280657(+) CCTATC/TCATTT 1 -- us2k15Minor allele frequency- T:0.29NA EA 246
    rs1144266991,2
    F--99280768(+) AGCCAC/GTCTCC 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1857333321,2
    --99280874(+) CTGAGC/GGTTGA 1 -- us2k10--------
    rs93729561,2
    C--99280951(+) GGACGC/TGATCC 1 -- us2k10--------
    rs1911481251,2
    --99281157(+) CGACGC/TGCCCG 1 -- us2k10--------
    rs1451985751,2
    --99281292(+) GCCCAC/TCGAAG 1 -- us2k10--------
    rs119688221,2
    C,A,H--99281393(+) CCAGCG/TGTAGG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1169993811,2
    F--99281405(+) GCACGG/AGGAAT 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs132091541,2
    C,F--99281407(+) ACGGGC/GAATCG 1 -- us2k12Minor allele frequency- G:0.25NA 4

    HapMap Linkage Disequilibrium report for POU3F2 (99282580 - 99286666 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for POU3F2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv6951n71CNV Loss21882294
    nsv886433CNV Loss21882294
    nsv823787CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600494    OMIM disorders: --

    9 diseases for POU3F2:    About MalaCards
    merkel cell carcinoma    microphthalmia    melanoma    retinoblastoma
    neuroblastoma    neuronitis    glioblastoma    schizophrenia
    cerebritis

    1 disease from the University of Copenhagen DISEASES database for POU3F2:
    Melanoma

    POU3F2 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for POU3F2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 61.8 33 18923447 (5), 7651733 (4), 18781132 (3), 15024080 (3) (see all 12)
    microphthalmia 50.2 2 7651733 (1), 7478537 (1)
    tumors 0 3 18781132 (1), 18829533 (1), 7651733 (1)

    Genetic Association Database (GAD): POU3F2
    Human Genome Epidemiology (HuGE) Navigator: POU3F2 (2 documents)

    Export disorders for POU3F2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU3F2 gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with POU3F2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif. (PubMed id 8441633)1, 2, 3 Schreiber E.... Fontana A. (1993)
    2. The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells. (PubMed id 7651733)1, 2, 9 Angus J.... Sturm R.A. (1995)
    3. Exclusion of mutations in the PRNP, JPH3, TBP, ATN1, CREBBP, POU3F2 and FTL genes as a cause of disease in Portuguese patients with a Huntington-like phenotype. (PubMed id 16858508)1, 4, 9 Costa M.d.o. .C....Maciel P. (2006)
    4. PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival. (PubMed id 10332029)1, 2, 9 Waragai M.... Okazawa H. (1999)
    5. A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. (PubMed id 19023125)1, 4 Potkin S.G....Macciardi F. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. Expression of a large family of POU-domain regulatory genes in mammalian brain development. (PubMed id 2739723)1, 2 He X....Rosenfeld M.G. (1989)
    9. Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16. (PubMed id 7601453)1, 9 Atanasoski S....Fontana A. (1995)
    10. SOX9 and SOX10 but not BRN2 are required for nestin expression in human melanoma cells. (PubMed id 18923447)1, 9 Flammiger A....Berking C. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5454 HGNC: 9215 AceView: POU3F2 Ensembl:ENSG00000184486 euGenes: HUgn5454
    ECgene: POU3F2 H-InvDB: POU3F2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POU3F2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POU3F2 gene:
    Search GeneIP for patents involving POU3F2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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