Aliases for POU3F2 Gene
External Ids for POU3F2 Gene
Previous HGNC Symbols for POU3F2 Gene
Previous GeneCards Identifiers for POU3F2 Gene
This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]
GeneCards Summary for POU3F2 Gene
POU3F2 (POU Class 3 Homeobox 2) is a Protein Coding gene. Diseases associated with POU3F2 include melanoma. Among its related pathways are SIDS Susceptibility Pathways and Neuroscience. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and identical protein binding. An important paralog of this gene is POU6F1.
UniProtKB/Swiss-Prot for POU3F2 Gene
Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, (GCAT) and (TAAT), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity).