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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU3F2 Gene

protein-coding   GIFtS: 59
GCID: GC06P099295

POU class 3 homeobox 2

(Previous names: POU domain class 3, transcription factor 2 )
(Previous symbol: OTF7)
 Explore 11 diseases affiliated with
POU3F2 via our new
 Human Malady Compendium 
Biological research products
for POU3F2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
POU Class 3 Homeobox 21 2     POU Domain Class 3, Transcription Factor 21
OCT71 2 3 5     N-Oct32
BRN21 2 3     Brain-23
OTF71 2 3     Brn-23
POUF31 2     Oct-73
Brain-Specific Homeobox/POU Domain Protein 22 3     POU Domain, Class 3, Transcription Factor 22
Nervous System-Specific Octamer-Binding Transcription Factor N-Oct-32 3     Brain-23
Octamer-Binding Protein 72 3     Brn-23
Octamer-Binding Transcription Factor 72 3     Oct-73
OTF-72 3     

External Ids:    HGNC: 92151   Entrez Gene: 54542   Ensembl: ENSG000001844867   OMIM: 6004945   UniProtKB: P202653   

Export aliases for POU3F2 gene to outside databases

Previous GC identifers: GC06P099150 GC06P099299 GC06P099328 GC06P099389 GC06P096721


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POU3F2:
This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in
neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes.
Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. (provided by
RefSeq, Mar 2012)

UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265
Function: Transcription factor that binds preferentially to the recognition sequence which consists of two distinct
half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively
regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity)

Gene Wiki entry for POU3F2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU3F2 gene promoter:
         TBP   AhR   C/EBPbeta   Pax-5   Tal-1   FOXD3   Arnt   E47   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOU3F2 promoter sequence
   Search SABiosciences Chromatin IP Primers for POU3F2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU3F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16   Ensembl cytogenetic band:  6q16.1   HGNC cytogenetic band: 6q16.2

POU3F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU3F2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P099295:  view genomic region     (about GC identifiers)

Start:
99,282,580 bp from pter      End:
99,286,666 bp from pter
Size:
4,087 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265 (See protein sequence)
Recommended Name: POU domain, class 3, transcription factor 2  
Size: 443 amino acids; 46893 Da
Subunit: Interacts with PQBP1
Subcellular location: Nucleus
Secondary accessions: Q14960 Q86V54 Q9UJL0
Alternative initiation: 3 isoforms:  P20265-1   P20265-2   P20265-3   

Explore the universe of human proteins at neXtProt for POU3F2: NX_P20265

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P20265

  • POU3F2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005595.2  
    ENSEMBL proteins: 
     ENSP00000329170  

    Human Recombinant Protein Products: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005667transcription factor complex IEA--


    POU3F2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    POU3F2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR016362 Transcription_factor_POU
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS

    Graphical View of Domain Structure for InterPro Entry P20265

    ProtoNet protein and cluster: P20265

    2 Blocks protein families:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265
    Similarity: Belongs to the POU transcription factor family. Class-3 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265
    Function: Transcription factor that binds preferentially to the recognition sequence which consists of two distinct
    half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively
    regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity)

         Genatlas biochemistry entry for POU3F2:
    POU domain,class 3,transcription factor 2,murine brain-2 (Brn-2) homolog

    10/1177 SABiosciences Target genes for POU3F2 (see all 1177):
    A2ML1 AAA1 ABCB8 ABHD10 ABHD4 ABI3BP ABLIM2 ACMSD ACN9 ACPL2

    miRNA
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    hsa-miR-579 hsa-miR-200a hsa-miR-301a hsa-miR-138-2* hsa-miR-1304 hsa-miR-141 hsa-miR-2113 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidPOU3F2 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001105RNA polymerase II transcription coactivator activity IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI11029584
    GO:0042802identical protein binding IPI11029584


    POU3F2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for POU3F2:
     Decreased Hepatitis C virus re 

    Animal Models:
         Mouse knock-outs for POU3F2: Pou3f2tm1Tno Pou3f2tm1Rsd
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pou3f2):
     adipose tissue  cellular  endocrine/exocrine gland  growth/size  integument 
     liver/biliary system  mortality/aging  nervous system 

    POU3F2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neuroscience
    Neuroscience1.00
    2Transcription factors in neurogenesis
    Transcription factors in neurogenesis1.00
    3SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for POU3F2
        Transcription factors in neurogenesis


    1 Cell Signaling Technology (CST) Pathway for POU3F2
        Neuroscience

    1 BioSystems Pathway for POU3F2 
        SIDS Susceptibility Pathways



    POU3F2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU3F2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/12 Interacting proteins for POU3F2 (P202651, 2, 3 ENSP000003291704) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBPP202261, 3, ENSP000002303544EBI-1167176,EBI-1056192 I2D: score=3 STRING: ENSP00000230354
    PAX3P237601, 3, ENSP000003759214EBI-1167176,EBI-1167564 I2D: score=2 STRING: ENSP00000375921
    SOX10P566931, 3, ENSP000003541304EBI-1167176,EBI-1167533 I2D: score=3 STRING: ENSP00000354130
    EP300Q094721, 3, ENSP000002632534EBI-1167176,EBI-3908041 I2D: score=2 STRING: ENSP00000263253
    SOX11P357163, ENSP000003225684I2D: score=1 STRING: ENSP00000322568
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0008284positive regulation of cell proliferation IDA15024079
    GO:0008544epidermis development IEA--
    GO:0014002astrocyte development IEA--


    POU3F2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POU3F2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POU3F2
    2 Novoseek chemical compound relationships for POU3F2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    l-amino acid 52.7 1 11311976 (1)
    oligonucleotide 5.21 2 8026890 (1), 9852081 (1)

    Search CenterWatch for drugs/clinical trials and news about POU3F2 / PO3F2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POU3F2 gene: 
    NM_005604.3  

    Unigene Cluster for POU3F2:

    POU class 3 homeobox 2
    Hs.182505  [show with all ESTs]
    Unigene Representative Sequence: BC051699
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000328345(uc003ppe.3)

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    hsa-miR-579 hsa-miR-200a hsa-miR-301a hsa-miR-138-2* hsa-miR-1304 hsa-miR-141 hsa-miR-2113 hsa-miR-130b
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    Additional cDNA sequence: 

    AK095588.1 BC051699.1 Z11933.1 

    2 DOTS entries:

    DT.436597  DT.102820716 

    24 AceView cDNA sequences:

    Z46167 BQ423615 BE855760 AL119023 F08761 NM_005604 BF983322 F05048 
    Z41794 BC051699 BX645336 D55919 F02230 Z11933 BU183021 BE765714 
    AI655029 BI914245 AW054773 F05989 BF978474 AL138356 AL708299 C15289 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU3F2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See POU3F2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POU3F2

    SOURCE GeneReport for Unigene cluster: Hs.182505

    UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265
    Tissue specificity: Expressed specifically in the neuroectodermal cell lineage

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for POU3F2 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia POU3F26
    --
    74(a)
    1 ↔ 1
    1(172183708-172184733)
    African clawed frog
    (Xenopus laevis)
    Amphibia pou3f2-A2 POU domain, class 3, transcription factor 2 80.67(n)    BC041298.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pou472 POU domain gene 47 82.95(n)   30397  NM_131160.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vvl3 peripheral nervous system development DNA
    binding
    94(a)
    (best of 3)
      3 65C5   --
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-63 Homeobox domain, Pou domain - N-terminal to
    homeobox more
    69(a)   I(8506480-8510320)   --


    ENSEMBL Gene Tree for POU3F2 (if available)
    TreeFam Gene Tree for POU3F2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POU3F2 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F42  POU3F12  POU1F12  POU4F32  
    POU3F32  POU2F22  POU5F1B2  POU2F12  POU4F12  POU5F12  POU6F12  
    14 SIMAP similar genes for POU3F2 using alignment to 1 protein entry:     PO3F2_HUMAN:
    POU6F1    POU3F4    POU1F1    POU4F3    POU5F1P4    POU3F3
    POU5F1    POU2F3    POU3F1    POU5F1P1    POU2F1    POU5F1B
    POU2F2    POU4F2

    POU3F2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/77 NCBI SNPs in POU3F2 are shown (see all 77    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402400611,2
    --99280593(+) CGCGGA/GTGCGC 1 -- us2k10--------
    rs132091381,2
    C,F,--99280657(+) CCTATC/TCATTT 1 -- us2k15Minor allele frequency- T:0.29NA EA 246
    rs1144266991,2
    F,--99280768(+) AGCCAC/GTCTCC 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1857333321,2
    --99280874(+) CTGAGC/GGTTGA 1 -- us2k10--------
    rs93729561,2
    --99280951(+) GGACGC/TGATCC 1 -- us2k10--------
    rs1911481251,2
    --99281157(+) CGACGC/TGCCCG 1 -- us2k10--------
    rs1451985751,2
    --99281292(+) GCCCAC/TCGAAG 1 -- us2k10--------
    rs119688221,2
    C,A,H--99281393(+) CCAGCG/TGTAGG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1169993811,2
    F,--99281405(+) GCACGG/AGGAAT 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs132091541,2
    C,--99281407(+) ACGGGC/GAATCG 1 -- us2k12Minor allele frequency- G:0.25NA 4

    HapMap Linkage Disequilibrium report for POU3F2 (99282580 - 99286666 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for POU3F2
         2 CNVs: 81507 93909

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    POU3F2 for disorders           About GeneDecksing

    OMIM gene information: 600494    OMIM disorders: --

    11 diseases for POU3F2:    About MalaCards
    melanoma    merkel cell carcinoma    microphthalmia    neuronitis
    embryonal carcinoma    retinoblastoma    glioblastoma    carcinoma
    cerebritis    neuroblastoma    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for POU3F2:
    Melanoma

    3 Novoseek disease relationships for POU3F2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 61.8 33 18923447 (5), 7651733 (4), 18781132 (3), 15024080 (3) (see all 12)
    microphthalmia 50.2 2 7651733 (1), 7478537 (1)
    tumors 0 3 18781132 (1), 18829533 (1), 7651733 (1)

    Human Genome Epidemiology (HuGE) Navigator: POU3F2 (2 documents)

    Export disorders for POU3F2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU3F2 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with POU3F2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif. (PubMed id 8441633)1, 2, 3 Schreiber E.... Fontana A. (1993)
    2. The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells. (PubMed id 7651733)1, 2, 9 Angus J.... Sturm R.A. (1995)
    3. PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival. (PubMed id 10332029)1, 2, 9 Waragai M.... Okazawa H. (1999)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Expression of a large family of POU-domain regulatory genes in mammalian brain development. (PubMed id 2739723)1, 2 He X....Rosenfeld M.G. (1989)
    7. Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16. (PubMed id 7601453)1, 9 Atanasoski S....Fontana A. (1995)
    8. SOX9 and SOX10 but not BRN2 are required for nestin expression in human melanoma cells. (PubMed id 18923447)1, 9 Flammiger A....Berking C. (2009)
    9. The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development. (PubMed id 12782656)1, 9 Jaegle M....Meijer D. (2003)
    10. The Brn-2 transcription factor links activated BRAF to melanoma proliferation. (PubMed id 15024080)1, 9 Goodall J....Goding C.R. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5454 HGNC: 9215 AceView: POU3F2 Ensembl:ENSG00000184486 euGenes: HUgn5454
    ECgene: POU3F2 H-InvDB: POU3F2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POU3F2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POU3F2 gene:
    Search GeneIP for patents involving POU3F2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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