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Aliases for POU3F2 Gene

Aliases for POU3F2 Gene

  • POU Class 3 Homeobox 2 2 3
  • OCT7 3 4 6
  • Nervous System-Specific Octamer-Binding Transcription Factor N-Oct-3 3 4
  • Brain-Specific Homeobox/POU Domain Protein 2 3 4
  • Octamer-Binding Transcription Factor 7 3 4
  • Octamer-Binding Protein 7 3 4
  • Brain-2 3 4
  • Brn-2 3 4
  • Oct-7 3 4
  • OTF-7 3 4
  • OTF7 3 4
  • BRN2 3 4
  • POU Domain, Class 3, Transcription Factor 2 3
  • POU Domain Class 3, Transcription Factor 2 2
  • N-Oct3 3
  • POUF3 3

External Ids for POU3F2 Gene

Previous HGNC Symbols for POU3F2 Gene

  • OTF7

Previous GeneCards Identifiers for POU3F2 Gene

  • GC06P099150
  • GC06P099299
  • GC06P099328
  • GC06P099295
  • GC06P099389
  • GC06P096721

Summaries for POU3F2 Gene

Entrez Gene Summary for POU3F2 Gene

  • This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]

GeneCards Summary for POU3F2 Gene

POU3F2 (POU Class 3 Homeobox 2) is a Protein Coding gene. Diseases associated with POU3F2 include melanoma. Among its related pathways are SIDS Susceptibility Pathways and Neuroscience. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and identical protein binding. An important paralog of this gene is POU6F1.

UniProtKB/Swiss-Prot for POU3F2 Gene

  • Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, (GCAT) and (TAAT), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity).

Gene Wiki entry for POU3F2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU3F2 Gene

Genomics for POU3F2 Gene

Regulatory Elements for POU3F2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POU3F2 Gene

Start:
98,834,592 bp from pter
End:
98,839,490 bp from pter
Size:
4,899 bases
Orientation:
Plus strand

Genomic View for POU3F2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POU3F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU3F2 Gene

Proteins for POU3F2 Gene

  • Protein details for POU3F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20265-PO3F2_HUMAN
    Recommended name:
    POU domain, class 3, transcription factor 2
    Protein Accession:
    P20265
    Secondary Accessions:
    • Q14960
    • Q86V54
    • Q9UJL0

    Protein attributes for POU3F2 Gene

    Size:
    443 amino acids
    Molecular mass:
    46893 Da
    Quaternary structure:
    • Interacts with PQBP1.

    Alternative splice isoforms for POU3F2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POU3F2 Gene

Proteomics data for POU3F2 Gene at MOPED

Post-translational modifications for POU3F2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU3F2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for POU3F2 (7-Oct)

No data available for DME Specific Peptides for POU3F2 Gene

Domains for POU3F2 Gene

Gene Families for POU3F2 Gene

HGNC:
  • POU :Homeoboxes / POU class

Protein Domains for POU3F2 Gene

Graphical View of Domain Structure for InterPro Entry

P20265

UniProtKB/Swiss-Prot:

PO3F2_HUMAN :
  • P20265
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 POU-specific domain.
Family:
  • Belongs to the POU transcription factor family. Class-3 subfamily.
genes like me logo Genes that share domains with POU3F2: view

Function for POU3F2 Gene

Molecular function for POU3F2 Gene

GENATLAS Biochemistry: POU domain,class 3,transcription factor 2,murine brain-2 (Brn-2) homolog
UniProtKB/Swiss-Prot Function: Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, (GCAT) and (TAAT), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity).

Gene Ontology (GO) - Molecular Function for POU3F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001105 RNA polymerase II transcription coactivator activity IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 11029584
GO:0042802 identical protein binding IPI 11029584
genes like me logo Genes that share ontologies with POU3F2: view
genes like me logo Genes that share phenotypes with POU3F2: view

Animal Models for POU3F2 Gene

MGI Knock Outs for POU3F2:

Animal Model Products

CRISPR Products

miRNA for POU3F2 Gene

miRTarBase miRNAs that target POU3F2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POU3F2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for POU3F2 Gene

Localization for POU3F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU3F2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POU3F2 Gene COMPARTMENTS Subcellular localization image for POU3F2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for POU3F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with POU3F2: view

Pathways for POU3F2 Gene

genes like me logo Genes that share pathways with POU3F2: view

Pathways by source for POU3F2 Gene

1 Cell Signaling Technology pathway for POU3F2 Gene
1 BioSystems pathway for POU3F2 Gene

Gene Ontology (GO) - Biological Process for POU3F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0008284 positive regulation of cell proliferation IDA 15024079
GO:0008544 epidermis development IEA --
genes like me logo Genes that share ontologies with POU3F2: view

Compounds for POU3F2 Gene

(2) Novoseek inferred chemical compound relationships for POU3F2 Gene

Compound -log(P) Hits PubMed IDs
l-amino acid 52.7 1
oligonucleotide 5.21 2
genes like me logo Genes that share compounds with POU3F2: view

Transcripts for POU3F2 Gene

mRNA/cDNA for POU3F2 Gene

(24) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POU3F2 Gene

POU class 3 homeobox 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POU3F2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for POU3F2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POU3F2 Gene

No ASD Table

Relevant External Links for POU3F2 Gene

GeneLoc Exon Structure for
POU3F2
ECgene alternative splicing isoforms for
POU3F2

Expression for POU3F2 Gene

mRNA expression in normal human tissues for POU3F2 Gene

mRNA differential expression in normal tissues according to GTEx for POU3F2 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (5.9), Brain - Substantia nigra (5.3), Brain - Nucleus accumbens (basal ganglia) (5.0), Brain - Amygdala (4.9), Brain - Putamen (basal ganglia) (4.5), Brain - Frontal Cortex (BA9) (4.2), Brain - Hippocampus (4.1), and Brain - Spinal cord (cervical c-1) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POU3F2 Gene

SOURCE GeneReport for Unigene cluster for POU3F2 Gene Hs.182505

mRNA Expression by UniProt/SwissProt for POU3F2 Gene

P20265-PO3F2_HUMAN
Tissue specificity: Expressed specifically in the neuroectodermal cell lineage
genes like me logo Genes that share expressions with POU3F2: view

In Situ Assay Products

Orthologs for POU3F2 Gene

This gene was present in the common ancestor of animals.

Orthologs for POU3F2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POU3F2 35
  • 97.07 (n)
  • 96.83 (a)
POU3F2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POU3F2 35
  • 96.12 (n)
  • 99.32 (a)
POU3F2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC481931 35
  • 96.75 (n)
  • 100 (a)
POU3F2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pou3f2 35
  • 93.83 (n)
  • 99.77 (a)
Pou3f2 16
Pou3f2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POU3F2 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pou3f2 35
  • 93.29 (n)
  • 99.1 (a)
lizard
(Anolis carolinensis)
Reptilia POU3F2 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia pou3f2-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486226 35
  • 79.47 (n)
  • 83.68 (a)
Str.12364 35
zebrafish
(Danio rerio)
Actinopterygii pou3f2a 36
  • 73 (a)
OneToMany
pou3f2b 35
  • 76.22 (n)
  • 78.25 (a)
pou3f2b 36
  • 74 (a)
OneToMany
pou47 35
fruit fly
(Drosophila melanogaster)
Insecta vvl 36
  • 47 (a)
OneToMany
nub 37
  • 62 (a)
vvl 37
  • 94 (a)
pdm2 37
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea ceh-6 37
  • 69 (a)
Species with no ortholog for POU3F2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POU3F2 Gene

ENSEMBL:
Gene Tree for POU3F2 (if available)
TreeFam:
Gene Tree for POU3F2 (if available)

Paralogs for POU3F2 Gene

Selected SIMAP similar genes for POU3F2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POU3F2: view

Variants for POU3F2 Gene

Sequence variations from dbSNP and Humsavar for POU3F2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs195860 -- 98,835,500(-) TGCAG(A/C)CCGGC synonymous-codon, reference
rs195861 -- 98,834,412(-) TCCCC(C/T)GGGCT upstream-variant-2KB
rs195862 -- 98,833,933(-) ACTTC(G/T)GCCCA upstream-variant-2KB
rs3823036 -- 98,836,656(-) AATCC(A/G)CAATA utr-variant-3-prime
rs5878562 -- 98,837,683(+) AAGTG(-/A)AAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for POU3F2 Gene

Variant ID Type Subtype PubMed ID
nsv886433 CNV Loss 21882294
nsv823787 CNV Gain 20364138
dgv6951n71 CNV Loss 21882294

Relevant External Links for POU3F2 Gene

HapMap Linkage Disequilibrium report
POU3F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU3F2 Gene

Disorders for POU3F2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for POU3F2 Gene including...

Search for POU3F2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for POU3F2 Gene

(3) Novoseek inferred disease relationships for POU3F2 Gene

Disease -log(P) Hits PubMed IDs
melanoma 61.8 26
microphthalmia 50.2 2
tumors 0 3

Relevant External Links for POU3F2

Genetic Association Database (GAD)
POU3F2
Human Genome Epidemiology (HuGE) Navigator
POU3F2
genes like me logo Genes that share disorders with POU3F2: view

No data available for UniProtKB/Swiss-Prot for POU3F2 Gene

Publications for POU3F2 Gene

  1. The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells. (PMID: 7651733) Angus J. … Sturm R.A. (Oncogene 1995) 3 4 23
  2. PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival. (PMID: 10332029) Waragai M. … Okazawa H. (Hum. Mol. Genet. 1999) 3 4 23
  3. Exclusion of mutations in the PRNP, JPH3, TBP, ATN1, CREBBP, POU3F2 and FTL genes as a cause of disease in Portuguese patients with a Huntington-like phenotype. (PMID: 16858508) Costa M.d.o. .C. … Maciel P. (J. Hum. Genet. 2006) 3 23 48
  4. cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif. (PMID: 8441633) Schreiber E. … Fontana A. (Nucleic Acids Res. 1993) 2 3 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4

Products for POU3F2 Gene

Sources for POU3F2 Gene

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