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POU3F2 Gene

protein-coding   GIFtS: 60
GCID: GC06P099295

POU Class 3 Homeobox 2

(Previous names: POU domain class 3, transcription factor 2)
(Previous symbol: OTF7)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
POU Class 3 Homeobox 21 2     N-Oct32
OTF71 2 3     POUF32
OCT72 3 5     brain-22
Brain-Specific Homeobox/POU Domain Protein 22 3     brn-22
Nervous System-Specific Octamer-Binding Transcription Factor N-Oct-32 3     oct-72
Octamer-Binding Protein 72 3     POU Domain, Class 3, Transcription Factor 22
Octamer-Binding Transcription Factor 72 3     Brain-23
BRN22 3     Brn-23
OTF-72 3     Oct-73
POU Domain Class 3, Transcription Factor 21     

External Ids:    HGNC: 92151   Entrez Gene: 54542   Ensembl: ENSG000001844867   OMIM: 6004945   UniProtKB: P202653   

Export aliases for POU3F2 gene to outside databases

Previous GC identifers: GC06P099150 GC06P099299 GC06P099328 GC06P099389 GC06P096721


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POU3F2 Gene:
This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved
in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes.
Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. (provided
by RefSeq, Mar 2012)

GeneCards Summary for POU3F2 Gene:
POU3F2 (POU class 3 homeobox 2) is a protein-coding gene. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265
Function: Transcription factor that binds preferentially to the recognition sequence which consists of two
distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides.
Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters
(By similarity)

Gene Wiki entry for POU3F2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the POU3F2 gene promoter:
         TBP   AhR   C/EBPbeta   Pax-5   Tal-1   FOXD3   Arnt   E47   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOU3F2 promoter sequence
   Search Chromatin IP Primers for POU3F2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU3F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16   Ensembl cytogenetic band:  6q16.1   HGNC cytogenetic band: 6q16.2

POU3F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU3F2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P099295:  view genomic region     (about GC identifiers)

Start:
99,282,580 bp from pter      End:
99,286,666 bp from pter
Size:
4,087 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265 (See protein sequence)
Recommended Name: POU domain, class 3, transcription factor 2  
Size: 443 amino acids; 46893 Da
Subunit: Interacts with PQBP1
Secondary accessions: Q14960 Q86V54 Q9UJL0
Alternative initiation: 3 isoforms:  P20265-1   P20265-2   P20265-3   

Explore the universe of human proteins at neXtProt for POU3F2: NX_P20265

Explore proteomics data for POU3F2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POU3F2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005595.2  
    ENSEMBL proteins: 
     ENSP00000329170  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POU: Homeoboxes / POU class

    Selected InterPro protein domains (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR016362 Transcription_factor_POU
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS

    Graphical View of Domain Structure for InterPro Entry P20265

    ProtoNet protein and cluster: P20265

    2 Blocks protein domains:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265
    Similarity: Belongs to the POU transcription factor family. Class-3 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    Find genes that share domains with POU3F2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO3F2_HUMAN, P20265
    Function: Transcription factor that binds preferentially to the recognition sequence which consists of two
    distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides.
    Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters
    (By similarity)

         Genatlas biochemistry entry for POU3F2:
    POU domain,class 3,transcription factor 2,murine brain-2 (Brn-2) homolog

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001105RNA polymerase II transcription coactivator activity IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI11029584
    GO:0042802identical protein binding IPI11029584
         
    Find genes that share ontologies with POU3F2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for POU3F2:
     Decreased Hepatitis C virus re 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pou3f2):
     adipose tissue  cellular  endocrine/exocrine gland  growth/size/body  integument 
     liver/biliary system  mortality/aging  nervous system 

    Find genes that share phenotypes with POU3F2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for POU3F2: Pou3f2tm1Tno Pou3f2tm1Rsd

       genOway: Develop your customized and physiologically relevant rodent model for POU3F2

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    miRTarBase miRNAs that target POU3F2:
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    Block miRNA regulation of human, mouse, rat POU3F2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate POU3F2 (see all 41):
    hsa-miR-579 hsa-miR-200a hsa-miR-301a hsa-miR-138-2* hsa-miR-1304 hsa-miR-141 hsa-miR-2113 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidPOU3F2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PO3F2_HUMAN, P20265: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--

    Find genes that share ontologies with POU3F2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POU3F2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcription factors in neurogenesis
    Transcription factors in neurogenesis
    2SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways
    3Neuroscience
    Neuroscience


    Find genes that share SuperPaths with POU3F2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for POU3F2
        Neuroscience

    1 BioSystems Pathway for POU3F2
        SIDS Susceptibility Pathways


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POU3F2
    Interactions:

        GeneGlobe Interaction Network for POU3F2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for POU3F2 (P202651, 2, 3 ENSP000003291704) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBPP202261, 3, ENSP000002303544EBI-1167176,EBI-355371 I2D: score=3 STRING: ENSP00000230354
    PAX3P237601, 3, ENSP000003759214EBI-1167176,EBI-1167564 I2D: score=2 STRING: ENSP00000375921
    SOX10P566931, 3, ENSP000003541304EBI-1167176,EBI-1167533 I2D: score=3 STRING: ENSP00000354130
    EP300Q094721, 3, ENSP000002632534EBI-1167176,EBI-447295 I2D: score=2 STRING: ENSP00000263253
    SOX11P357163, ENSP000003225684I2D: score=1 STRING: ENSP00000322568
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0008284positive regulation of cell proliferation IDA15024079
    GO:0008544epidermis development IEA--
    GO:0014002astrocyte development IEA--

    Find genes that share ontologies with POU3F2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for POU3F2 (PO3F2)

    2 Novoseek inferred chemical compound relationships for POU3F2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    l-amino acid 52.7 1 11311976 (1)
    oligonucleotide 5.21 2 8026890 (1), 9852081 (1)



    Find genes that share compounds with POU3F2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POU3F2 gene: 
    NM_005604.3  

    Unigene Cluster for POU3F2:

    POU class 3 homeobox 2
    Hs.182505  [show with all ESTs]
    Unigene Representative Sequence: BC051699
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000328345(uc003ppe.3)
    miRNA
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    hsa-miR-579 hsa-miR-200a hsa-miR-301a hsa-miR-138-2* hsa-miR-1304 hsa-miR-141 hsa-miR-2113 hsa-miR-130b
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    Additional mRNA sequence: 

    AK095588.1 BC051699.1 Z11933.1 

    2 DOTS entries:

    DT.436597  DT.102820716 

    24 AceView cDNA sequences:

    NM_005604 BQ423615 BF983322 F08761 AL119023 BE855760 F05048 Z46167 
    BX645336 BE765714 BU183021 F02230 D55919 Z11933 BC051699 Z41794 
    AI655029 AW054773 BI914245 C15289 AL138356 BF978474 F05989 AL708299 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    POU3F2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    POU3F2 Expression
    About this image


    POU3F2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Pro-myelinating Schwann Cells Peripheral Nerve Domain
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             Oligodendrocyte-like cells
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
             Floor plate-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Oligodendrocytes (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
    POU3F2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POU3F2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.182505

    UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265
    Tissue specificity: Expressed specifically in the neuroectodermal cell lineage

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for POU3F2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou3f21 , 5 POU domain, class 3, transcription factor 21, 5 93.83(n)1
    99.77(a)1
      4 (9.73 cM)5
    189921  NM_008899.21  NP_032925.11 
     224855215 
    lizard
    (Anolis carolinensis)
    Reptilia POU3F26
    POU class 3 homeobox 2
    86(a)
    1 ↔ 1
    1(172183708-172184733)
    African clawed frog
    (Xenopus laevis)
    Amphibia pou3f2-A2 POU domain, class 3, transcription factor 2 80.67(n)    BC041298.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pou472 POU domain gene 47 82.95(n)   30397  NM_131160.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vvl3 peripheral nervous system development
    DNA binding less
    94(a)
    (best of 3)
      3 65C5   --


    ENSEMBL Gene Tree for POU3F2 (if available)
    TreeFam Gene Tree for POU3F2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POU3F2 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F12  POU3F42  POU1F12  POU3F32  
    POU4F32  POU2F22  POU5F1B2  POU4F12  POU2F12  POU6F12  POU5F12  
    13 SIMAP similar genes for POU3F2 using alignment to 1 protein entry:     PO3F2_HUMAN:
    POU6F1    POU3F4    POU1F1    POU4F3    POU5F1P4    POU3F3
    POU5F1    POU3F1    POU2F3    POU5F1P1    POU2F1    POU5F1B
    POU2F2

    Find genes that share paralogs with POU3F2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POU3F2 (see all 98)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402400611,2
    --99280593(+) CGCGGA/GTGCGC 1 -- us2k10--------
    rs132091381,2
    C,F--99280657(+) CCTATC/TCATTT 1 -- us2k15Minor allele frequency- T:0.29NA EA 246
    rs1144266991,2
    F--99280768(+) AGCCAC/GTCTCC 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1857333321,2
    --99280874(+) CTGAGC/GGTTGA 1 -- us2k10--------
    rs93729561,2
    C--99280951(+) GGACGC/TGATCC 1 -- us2k10--------
    rs1911481251,2
    --99281157(+) CGACGC/TGCCCG 1 -- us2k10--------
    rs1451985751,2
    --99281292(+) GCCCAC/TCGAAG 1 -- us2k10--------
    rs119688221,2
    C,A,H--99281393(+) CCAGCG/TGTAGG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1169993811,2
    F--99281405(+) GCACGG/AGGAAT 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs132091541,2
    C,F--99281407(+) ACGGGC/GAATCG 1 -- us2k12Minor allele frequency- G:0.25NA 4

    HapMap Linkage Disequilibrium report for POU3F2 (99282580 - 99286666 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for POU3F2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6951n71CNV Loss21882294
    nsv886433CNV Loss21882294
    nsv823787CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POU3F2
    DNA2.0 Custom Variant and Variant Library Synthesis for POU3F2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600494    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for POU3F2:
    Melanoma

    Find genes that share disorders with POU3F2           About GenesLikeMe

    3 Novoseek inferred disease relationships for POU3F2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 61.8 33 18923447 (5), 7651733 (4), 18781132 (3), 15024080 (3) (see all 12)
    microphthalmia 50.2 2 7651733 (1), 7478537 (1)
    tumors 0 3 18781132 (1), 18829533 (1), 7651733 (1)

    Genetic Association Database (GAD): POU3F2
    Human Genome Epidemiology (HuGE) Navigator: POU3F2 (2 documents)

    Export disorders for POU3F2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POU3F2 gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with POU3F2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif. (PubMed id 8441633)1, 2, 3 Schreiber E.... Fontana A. (Nucleic Acids Res. 1993)
    2. The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells. (PubMed id 7651733)1, 2, 9 Angus J.... Sturm R.A. (Oncogene 1995)
    3. Exclusion of mutations in the PRNP, JPH3, TBP, ATN1, CREBBP, POU3F2 and FTL genes as a cause of disease in Portuguese patients with a Huntington-like phenotype. (PubMed id 16858508)1, 4, 9 Costa M.d.o. .C....Maciel P. (J. Hum. Genet. 2006)
    4. PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival. (PubMed id 10332029)1, 2, 9 Waragai M.... Okazawa H. (Hum. Mol. Genet. 1999)
    5. A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. (PubMed id 19023125)1, 4 Potkin S.G....Macciardi F. (Schizophr Bull 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. Expression of a large family of POU-domain regulatory genes in mammalian brain development. (PubMed id 2739723)1, 2 He X....Rosenfeld M.G. (Nature 1989)
    9. Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16. (PubMed id 7601453)1, 9 Atanasoski S....Fontana A. (Genomics 1995)
    10. SOX9 and SOX10 but not BRN2 are required for nestin expression in human melanoma cells. (PubMed id 18923447)1, 9 Flammiger A....Berking C. (J. Invest. Dermatol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5454 HGNC: 9215 AceView: POU3F2 Ensembl:ENSG00000184486 euGenes: HUgn5454
    ECgene: POU3F2 H-InvDB: POU3F2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for POU3F2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for POU3F2 gene:
    Search GeneIP for patents involving POU3F2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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