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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

POU3F2 Gene

protein-coding GIFtS: 60
GCID: GC06P099295

POU Class 3 Homeobox 2

(Previous names: POU domain class 3, transcription factor 2)
(Previous symbol: OTF7)

9 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
POU Class 3 Homeobox 2¹ ²		N-Oct3²
OTF7¹ ² ³		POUF3²
OCT7² ³ ⁵		brain-2²
Brain-Specific Homeobox/POU Domain Protein 2² ³		brn-2²
Nervous System-Specific Octamer-Binding Transcription Factor N-Oct-3² ³		oct-7²
Octamer-Binding Protein 7² ³		POU Domain, Class 3, Transcription Factor 2²
Octamer-Binding Transcription Factor 7² ³		Brain-2³
BRN2² ³		Brn-2³
OTF-7² ³		Oct-7³
POU Domain Class 3, Transcription Factor 2¹

External Ids:	HGNC: 9215¹	Entrez Gene: 5454²	Ensembl: ENSG00000184486⁷	OMIM: 600494⁵	UniProtKB: P20265³

Export aliases for POU3F2 gene to outside databases

Previous GC identifers: GC06P099150 GC06P099299 GC06P099328 GC06P099389 GC06P096721

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POU3F2 Gene:

This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in

neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes.

Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. (provided by

RefSeq, Mar 2012)

GeneCards Summary for POU3F2 Gene:

POU3F2 (POU class 3 homeobox 2) is a protein-coding gene. Diseases associated with POU3F2 include merkel cell carcinoma, and microphthalmia. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265

Function: Transcription factor that binds preferentially to the recognition sequence which consists of two distinct

half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively

regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity)

Gene Wiki entry for POU3F2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.2 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the POU3F2 gene promoter:
TBP AhR C/EBPbeta Pax-5 Tal-1 FOXD3 Arnt E47 POU2F1 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POU3F2 promoter sequence

Search SABiosciences Chromatin IP Primers for POU3F2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU3F2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16 Ensembl cytogenetic band: 6q16.1 HGNC cytogenetic band: 6q16.2

POU3F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU3F2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P099295: view genomic region (about GC identifiers)

Start:	99,282,580 bp from pter	End:	99,286,666 bp from pter
Size:	4,087 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265 (See protein sequence)

Recommended Name: POU domain, class 3, transcription factor 2

Size: 443 amino acids; 46893 Da

Subunit: Interacts with PQBP1

Subcellular location: Nucleus

Secondary accessions: Q14960 Q86V54 Q9UJL0

Alternative initiation: 3 isoforms: P20265-1 P20265-2 P20265-3

Explore the universe of human proteins at neXtProt for POU3F2: NX_P20265

Explore proteomics data for POU3F2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P20265

POU3F2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_005595.2

ENSEMBL proteins:

ENSP00000329170

Human Recombinant Protein Products for POU3F2:

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	Novus Biologicals POU3F2 Proteins Novus Biologicals POU3F2 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005667	transcription factor complex	IEA	--

POU3F2 for ontologies About GeneDecksing

POU3F2 Antibody Products:

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Assay Products for POU3F2:

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	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

POU: Homeoboxes / POU class

5/7 InterPro protein domains (see all 7):

IPR010982 Lambda_DNA-bd_dom

IPR016362 Transcription_factor_POU

IPR013847 POU

IPR000327 POU_specific

IPR017970 Homeobox_CS

Graphical View of Domain Structure for InterPro Entry P20265

ProtoNet protein and cluster: P20265

2 Blocks protein domains:

IPB000327 POU domain

IPB013847 POU

UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265

Similarity: Belongs to the POU transcription factor family. Class-3 subfamily

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 1 POU-specific domain

POU3F2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PO3F2_HUMAN, P20265

Function: Transcription factor that binds preferentially to the recognition sequence which consists of two distinct

half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively

regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity)

Genatlas biochemistry entry for POU3F2:

POU domain,class 3,transcription factor 2,murine brain-2 (Brn-2) homolog

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001105	RNA polymerase II transcription coactivator activity	IEA	--
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	11029584
GO:0042802	identical protein binding	IPI	11029584

POU3F2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for POU3F2:

Decreased Hepatitis C virus re

8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Pou3f2):

adipose tissue	cellular	endocrine/exocrine gland	growth/size	integument
liver/biliary system	mortality/aging	nervous system

POU3F2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for POU3F2: Pou3f2^tm1Tno Pou3f2^tm1Rsd

inGenious Targeting Laboratory - Custom generated mouse model solutions for POU3F2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POU3F2

		10/1150 SABiosciences Target genes for POU3F2 (see all 1150):
		A2ML1 AAA1 ABCB8 ABHD10 ABHD4 ABI3BP ABLIM2 ACMSD ACN9 ACPL2

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU3F2
		8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate POU3F2 (see all 41):
		hsa-miR-579 hsa-miR-200a hsa-miR-301a hsa-miR-138-2* hsa-miR-1304 hsa-miR-141 hsa-miR-2113 hsa-miR-130b

		SwitchGear 3'UTR luciferase reporter plasmid: POU3F2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for POU3F2
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for POU3F2 (see all 5) OriGene ORF clones in mouse, rat for POU3F2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: POU3F2 (NM_005604)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for POU3F2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU3F2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for POU3F2 About

See pathways by source

SuperPath

Contained pathways About

Transcription factors in neurogenesis

Transcription factors in neurogenesis

Neuroscience

Neuroscience

SIDS Susceptibility Pathways

SIDS Susceptibility Pathways

Pathways by source See SuperPaths
Show all pathways

1 EMD Millipore Pathway for POU3F2

Transcription factors in neurogenesis

1 Cell Signaling Technology (CST) Pathway for POU3F2

Neuroscience

1 BioSystems Pathway for POU3F2

SIDS Susceptibility Pathways

POU3F2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for POU3F2

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/12 Interacting proteins for POU3F2 (P20265^{1, 2, 3} ENSP00000329170⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TBP	P20226¹^,³, ENSP00000230354⁴	EBI-1167176,EBI-355371 I2D: score=3 STRING: ENSP00000230354
PAX3	P23760¹^,³, ENSP00000375921⁴	EBI-1167176,EBI-1167564 I2D: score=2 STRING: ENSP00000375921
SOX10	P56693¹^,³, ENSP00000354130⁴	EBI-1167176,EBI-1167533 I2D: score=3 STRING: ENSP00000354130
EP300	Q09472¹^,³, ENSP00000263253⁴	EBI-1167176,EBI-447295 I2D: score=2 STRING: ENSP00000263253
SOX11	P35716³, ENSP00000322568⁴	I2D: score=1 STRING: ENSP00000322568

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	--	--
GO:0008284	positive regulation of cell proliferation	IDA	15024079
GO:0008544	epidermis development	IEA	--
GO:0014002	astrocyte development	IEA	--

POU3F2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

POU3F2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POU3F2 (PO3F2)

2 Novoseek inferred chemical compound relationships for POU3F2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
l-amino acid	52.7	1	11311976 (1)
oligonucleotide	5.21	2	8026890 (1), 9852081 (1)

Search CenterWatch for drugs/clinical trials and news about POU3F2 / PO3F2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for POU3F2 gene:

NM_005604.3

Unigene Cluster for POU3F2:

POU class 3 homeobox 2

Hs.182505 [show with all ESTs]

Unigene Representative Sequence: BC051699

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000328345(uc003ppe.3)

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU3F2
		8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate POU3F2 (see all 41):
		hsa-miR-579 hsa-miR-200a hsa-miR-301a hsa-miR-138-2* hsa-miR-1304 hsa-miR-141 hsa-miR-2113 hsa-miR-130b

		SwitchGear 3'UTR luciferase reporter plasmid: POU3F2 3' UTR sequence

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		Sirion Biotech Custom design and validation of potent shRNA sequences against POU3F2

Clone Products:		OriGene clones in human, mouse for POU3F2 (see all 5) OriGene ORF clones in mouse, rat for POU3F2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: POU3F2 (NM_005604)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU3F2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU3F2

Additional mRNA sequence:

AK095588.1 BC051699.1 Z11933.1

2 DOTS entries:

DT.436597 DT.102820716

24 AceView cDNA sequences:

AL119023 NM_005604 BE855760 BF983322 Z46167 F05048 F08761 BQ423615

Z41794 BC051699 BX645336 BE765714 F02230 Z11933 D55919 BU183021

BI914245 AW054773 AI655029 C15289 AL708299 F05989 AL138356 BF978474

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

POU3F2 expression in normal human tissues (normalized intensities) POU3F2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

POU3F2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/9 selected tissues (see all 9) fully expand


Brain (Nervous System) fully expand to see all 3 entries
Cerebral Cortex
cortex

Neural Ectoderm (Nervous System) fully expand to see all 2 entries
Floor plate-like cells (Generation of functional floor plate or neuroectoderm cells...

Limb (Muscoskeletal System) fully expand to see all 2 entries
limb/hindlimb

Neural Tube (Nervous System)
Telencephalon

Lower Urinary Tract (Urinary System)
visceral organ

See POU3F2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POU3F2

SOURCE GeneReport for Unigene cluster: Hs.182505

UniProtKB/Swiss-Prot: PO3F2_HUMAN, P20265

Tissue specificity: Expressed specifically in the neuroectodermal cell lineage

SABiosciences Custom PCR Arrays for POU3F2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU3F2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for POU3F2 gene from 6/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pou3f2^{1 , 5}	POU domain, class 3, transcription factor 2^{1, 5}	93.75(n)¹ 100(a)¹		4 (9.73 cM)⁵ 18992¹ NM_008899.2¹ NP_032925.1¹ 22486644⁵
lizard (Anolis carolinensis)	Reptilia	POU3F2⁶	Uncharacterized protein	76(a)	1 ↔ 1	1(172183708-172184733)
African clawed frog (Xenopus laevis)	Amphibia	pou3f2-A²	POU domain, class 3, transcription factor 2	80.67(n)		BC041298.1
zebrafish (Danio rerio)	Actinopterygii	pou47²	POU domain gene 47	82.95(n)		30397 NM_131160.1
fruit fly (Drosophila melanogaster)	Insecta	vvl³	peripheral nervous system development DNA binding	94(a) (best of 3)		3 65C5 --
worm (Caenorhabditis elegans)	Secernentea	ceh-6³	Homeobox domain, Pou domain - N-terminal to homeobox more	69(a)		I(8506480-8510320) --

ENSEMBL Gene Tree for POU3F2 (if available)
TreeFam Gene Tree for POU3F2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for POU3F2 gene

POU5F2² POU6F2² POU4F2² POU2F3² POU3F1² POU3F4² POU1F1² POU3F3²

POU4F3² POU2F2² POU5F1B² POU4F1² POU2F1² POU6F1² POU5F1²

13 SIMAP similar genes for POU3F2 using alignment to 1 protein entry: PO3F2_HUMAN:

POU6F1 POU3F4 POU1F1 POU4F3 POU5F1P4 POU3F3

POU5F1 POU2F3 POU3F1 POU5F1P1 POU2F1 POU5F1B

POU2F2

POU3F2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140240061^1,2		--	99280593(+)	`CGCGGA/GTGCGC`	1	--	us2k¹		0	--	--	--	--
rs13209138^1,2	C,F	--	99280657(+)	`CCTATC/TCATTT`	1	--	us2k¹		5		NA EA	246
rs114426699^1,2	F	--	99280768(+)	`AGCCAC/GTCTCC`	1	--	us2k¹		1		WA	118
rs185733332^1,2		--	99280874(+)	`CTGAGC/GGTTGA`	1	--	us2k¹		0	--	--	--	--
rs9372956^1,2	C	--	99280951(+)	`GGACGC/TGATCC`	1	--	us2k¹		0	--	--	--	--
rs191148125^1,2		--	99281157(+)	`CGACGC/TGCCCG`	1	--	us2k¹		0	--	--	--	--
rs145198575^1,2		--	99281292(+)	`GCCCAC/TCGAAG`	1	--	us2k¹		0	--	--	--	--
rs11968822^1,2	C,A,H	--	99281393(+)	`CCAGCG/TGTAGG`	1	--	us2k¹		1		NA	2
rs116999381^1,2	F	--	99281405(+)	`GCACGG/AGGAAT`	1	--	us2k¹		1		EA	120
rs13209154^1,2	C,F	--	99281407(+)	`ACGGGC/GAATCG`	1	--	us2k¹		2		NA	4

HapMap Linkage Disequilibrium report for POU3F2 (99282580 - 99286666 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for POU3F2: About this table

Variant ID	Type	Subtype	PubMed ID
dgv6951n71	CNV	Loss	21882294
nsv886433	CNV	Loss	21882294
nsv823787	CNV	Gain	20364138

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

POU3F2 for disorders           About GeneDecksing

OMIM gene information: 600494    OMIM disorders: --

9 diseases for POU3F2:    About MalaCards

merkel cell carcinoma microphthalmia melanoma retinoblastoma

neuroblastoma neuronitis glioblastoma schizophrenia

cerebritis

1 disease from the University of Copenhagen DISEASES database for POU3F2:

Melanoma

3 Novoseek inferred disease relationships for POU3F2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
melanoma	61.8	33	18923447 (5), 7651733 (4), 18781132 (3), 15024080 (3) (see all 12)
microphthalmia	50.2	2	7651733 (1), 7478537 (1)
tumors	0	3	18781132 (1), 18829533 (1), 7651733 (1)

Genetic Association Database (GAD): POU3F2
Human Genome Epidemiology (HuGE) Navigator: POU3F2 (2 documents)

Export disorders for POU3F2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for POU3F2 gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with POU3F2)

Utopia: connect your pdf to the dynamic
world of online information

cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif. (PubMed id 8441633)^{1, 2, 3} Schreiber E.... Fontana A. (1993)
The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells. (PubMed id 7651733)^{1, 2, 9} Angus J.... Sturm R.A. (1995)
Exclusion of mutations in the PRNP, JPH3, TBP, ATN1, CREBBP, POU3F2 and FTL genes as a cause of disease in Portuguese patients with a Huntington-like phenotype. (PubMed id 16858508)^{1, 4, 9} Costa M.d.o. .C....Maciel P. (2006)
PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival. (PubMed id 10332029)^{1, 2, 9} Waragai M.... Okazawa H. (1999)
A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. (PubMed id 19023125)^{1, 4} Potkin S.G....Macciardi F. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Expression of a large family of POU-domain regulatory genes in mammalian brain development. (PubMed id 2739723)^{1, 2} He X....Rosenfeld M.G. (1989)
Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16. (PubMed id 7601453)^{1, 9} Atanasoski S....Fontana A. (1995)
SOX9 and SOX10 but not BRN2 are required for nestin expression in human melanoma cells. (PubMed id 18923447)^{1, 9} Flammiger A....Berking C. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5454	HGNC: 9215	AceView: POU3F2	Ensembl:ENSG00000184486	euGenes: HUgn5454
ECgene: POU3F2	H-InvDB: POU3F2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for POU3F2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for POU3F2 gene
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Patent Information for POU3F2 gene:
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POU3F2 Gene

POU Class 3 Homeobox 2

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POU3F2 (Gene Symbol)
POU Class 3 Homeobox 2
OTF7
OCT7
Brain-Specific Homeobox/POU Domain Protein 2
Nervous System-Specific Octamer-Binding Transcription Factor N-Oct-3
Octamer-Binding Protein 7
Octamer-Binding Transcription Factor 7
BRN2
OTF-7
POU Domain Class 3, Transcription Factor 2
N-Oct3
POUF3
brain-2
brn-2
oct-7
POU Domain, Class 3, Transcription Factor 2
Brain-2
Brn-2
Oct-7

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POU3F2 Gene

POU Class 3 Homeobox 2

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