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POU3F2 Gene(Protein Coding)

POU Class 3 Homeobox 2

GCID:
GC06P098834
GIFtS:
59
Genes Participants
UDN Logo

Aliases for POU3F2 Gene

Aliases for POU3F2 Gene

  • POU Class 3 Homeobox 2 2 3 5
  • Nervous System-Specific Octamer-Binding Transcription Factor N-Oct-3 3 4
  • Brain-Specific Homeobox/POU Domain Protein 2 3 4
  • Octamer-Binding Transcription Factor 7 3 4
  • Octamer-Binding Protein 7 3 4
  • Brain-2 3 4
  • Brn-2 3 4
  • Oct-7 3 4
  • OTF-7 3 4
  • OTF7 3 4
  • BRN2 3 4
  • OCT7 3 4
  • POU Domain Class 3, Transcription Factor 2 2
  • N-Oct3 3
  • POUF3 3

External Ids for POU3F2 Gene

Previous HGNC Symbols for POU3F2 Gene

  • OTF7

Previous GeneCards Identifiers for POU3F2 Gene

  • GC06P099150
  • GC06P099299
  • GC06P099328
  • GC06P099295
  • GC06P099389
  • GC06P096721

Summaries for POU3F2 Gene

Entrez Gene Summary for POU3F2 Gene

  • This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]

GeneCards Summary for POU3F2 Gene

POU3F2 (POU Class 3 Homeobox 2) is a Protein Coding gene. Among its related pathways are SIDS Susceptibility Pathways and Neuroscience. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and identical protein binding. An important paralog of this gene is POU6F1.

UniProtKB/Swiss-Prot for POU3F2 Gene

  • Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, (GCAT) and (TAAT), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity).

Gene Wiki entry for POU3F2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU3F2 Gene

Genomics for POU3F2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for POU3F2 Gene

Enhancers for POU3F2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POU3F2 on UCSC Golden Path with GeneCards custom track

Promoters for POU3F2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POU3F2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the POU3F2 gene promoter:

Genomic Location for POU3F2 Gene

Chromosome:
6
Start:
98,834,592 bp from pter
End:
98,839,490 bp from pter
Size:
4,899 bases
Orientation:
Plus strand

Genomic View for POU3F2 Gene

Genes around POU3F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POU3F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POU3F2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for POU3F2 Gene

Proteins for POU3F2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for POU3F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20265-PO3F2_HUMAN
    Recommended name:
    POU domain, class 3, transcription factor 2
    Protein Accession:
    P20265
    Secondary Accessions:
    • Q14960
    • Q86V54
    • Q9UJL0

    Protein attributes for POU3F2 Gene

    Size:
    443 amino acids
    Molecular mass:
    46893 Da
    Quaternary structure:
    • Interacts with PQBP1.

    Alternative splice isoforms for POU3F2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POU3F2 Gene

Proteomics data for POU3F2 Gene at MOPED

Protein Expression for POU3F2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for POU3F2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU3F2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for POU3F2 (7-Oct)

No data available for DME Specific Peptides for POU3F2 Gene

Domains & Families for POU3F2 Gene

Gene Families for POU3F2 Gene

HGNC:

Protein Domains for POU3F2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for POU3F2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20265

UniProtKB/Swiss-Prot:

PO3F2_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the POU transcription factor family. Class-3 subfamily.
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 POU-specific domain.
Family:
  • Belongs to the POU transcription factor family. Class-3 subfamily.
genes like me logo Genes that share domains with POU3F2: view

Function for POU3F2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for POU3F2 Gene

GENATLAS Biochemistry:
POU domain,class 3,transcription factor 2,murine brain-2 (Brn-2) homolog
UniProtKB/Swiss-Prot Function:
Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, (GCAT) and (TAAT), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity).

Phenotypes for POU3F2 Gene

MGI mutant phenotypes for POU3F2:
inferred from 3 alleles
GenomeRNAi human phenotypes for POU3F2:
genes like me logo Genes that share phenotypes with POU3F2: view

Animal Models for POU3F2 Gene

MGI Knock Outs for POU3F2:

Animal Model Products

CRISPR Products

miRNA for POU3F2 Gene

miRTarBase miRNAs that target POU3F2

Transcription Factor Targets for POU3F2 Gene

Selected GeneGlobe predicted Target genes for POU3F2
Targeted motifs for POU3F2 Gene
HOMER Transcription Factor Regulatory Elements motif POU3F2
  • Consensus sequence: ATGAATATTC Submotif: canonical Cell Type: NPC GEO ID: GSE35496

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function and Human Phenotype Ontology for POU3F2 Gene

Localization for POU3F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU3F2 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POU3F2 Gene COMPARTMENTS Subcellular localization image for POU3F2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for POU3F2 Gene

Pathways & Interactions for POU3F2 Gene

genes like me logo Genes that share pathways with POU3F2: view

Pathways by source for POU3F2 Gene

1 Cell Signaling Technology pathway for POU3F2 Gene
1 BioSystems pathway for POU3F2 Gene

Gene Ontology (GO) - Biological Process for POU3F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007420 brain development IEA --
GO:0010629 negative regulation of gene expression IEA --
GO:0021799 cerebral cortex radially oriented cell migration IEA --
GO:0021869 forebrain ventricular zone progenitor cell division IEA --
genes like me logo Genes that share ontologies with POU3F2: view

No data available for SIGNOR curated interactions for POU3F2 Gene

Drugs & Compounds for POU3F2 Gene

Products:

  1. Drug

(2) Additional Compounds for POU3F2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with POU3F2: view

Transcripts for POU3F2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for POU3F2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POU3F2 Gene

POU class 3 homeobox 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POU3F2 Gene

No ASD Table

Relevant External Links for POU3F2 Gene

GeneLoc Exon Structure for
POU3F2
ECgene alternative splicing isoforms for
POU3F2

Expression for POU3F2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for POU3F2 Gene

mRNA expression in normal human tissues for POU3F2 Gene
mRNA expression by BioGPS for POU3F2 GenemRNA expression by GTEx for POU3F2 Gene

mRNA differential expression in normal tissues according to GTEx for POU3F2 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x5.9), Brain - Substantia nigra (x5.3), Brain - Nucleus accumbens (basal ganglia) (x5.0), Brain - Amygdala (x4.9), Brain - Putamen (basal ganglia) (x4.5), Brain - Frontal Cortex (BA9) (x4.2), Brain - Hippocampus (x4.1), and Brain - Spinal cord (cervical c-1) (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POU3F2 Gene



SOURCE GeneReport for Unigene cluster for POU3F2 Gene Hs.182505

mRNA Expression by UniProt/SwissProt for POU3F2 Gene

P20265-PO3F2_HUMAN
Tissue specificity: Expressed specifically in the neuroectodermal cell lineage.
genes like me logo Genes that share expression patterns with POU3F2: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for POU3F2 Gene

Orthologs for POU3F2 Gene

This gene was present in the common ancestor of animals.

Orthologs for POU3F2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia POU3F2 35
  • 96.12 (n)
  • 99.32 (a)
POU3F2 36
  • 98 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia LOC481931 35
  • 96.75 (n)
  • 100 (a)
POU3F2 36
  • 100 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Pou3f2 35
  • 93.83 (n)
  • 99.77 (a)
Pou3f2 16
Pou3f2 36
  • 100 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia POU3F2 35
  • 97.07 (n)
  • 96.83 (a)
POU3F2 36
  • 97 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Pou3f2 35
  • 93.29 (n)
  • 99.1 (a)
oppossum
(Monodelphis domestica)
 Mammalia POU3F2 36
  • 97 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 65 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia POU3F2 36
  • 86 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100486226 35
  • 79.47 (n)
  • 83.68 (a)
Str.12364 35
African clawed frog
(Xenopus laevis)
 Amphibia pou3f2-A 35
zebrafish
(Danio rerio)
 Actinopterygii pou3f2b 35
  • 76.22 (n)
  • 78.25 (a)
pou47 35
pou3f2a 36
  • 73 (a)
 OneToMany
pou3f2b 36
  • 74 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta nub 37
  • 62 (a)
pdm2 37
  • 61 (a)
vvl 37
  • 94 (a)
vvl 36
  • 47 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea ceh-6 37
  • 69 (a)
Species with no ortholog for POU3F2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POU3F2 Gene

ENSEMBL:
Gene Tree for POU3F2 (if available)
TreeFam:
Gene Tree for POU3F2 (if available)

Paralogs for POU3F2 Gene

Paralogs for POU3F2 Gene

(13) SIMAP similar genes for POU3F2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POU3F2: view

Variants for POU3F2 Gene

Sequence variations from dbSNP and Humsavar for POU3F2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs5878562 -- 98,837,683(+) AAGTG(-/A)AAAAA utr-variant-3-prime
rs195860 -- 98,835,500(-) TGCAG(A/C)CCGGC reference, synonymous-codon
rs195861 -- 98,834,412(-) TCCCC(C/T)GGGCT upstream-variant-2KB
rs195862 -- 98,833,933(-) ACTTC(G/T)GCCCA upstream-variant-2KB
rs11968822 -- 98,833,517(+) CCAGC(G/T)GTAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for POU3F2 Gene

Variant ID Type Subtype PubMed ID
nsv886433 CNV Loss 21882294
nsv823787 CNV Gain 20364138
dgv6951n71 CNV Loss 21882294

Variation tolerance for POU3F2 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for POU3F2 Gene

Disorders for POU3F2 Gene

Relevant External Links for POU3F2

Genetic Association Database (GAD)
POU3F2
Human Genome Epidemiology (HuGE) Navigator
POU3F2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POU3F2

No disorders were found for POU3F2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POU3F2 Gene

Publications for POU3F2 Gene

  1. cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif. (PMID: 8441633) Schreiber E. … Fontana A. (Nucleic Acids Res. 1993) 2 3 4 67
  2. Genome-wide analysis of POU3F2/BRN2 promoter occupancy in human melanoma cells reveals Kitl as a novel regulated target gene. (PMID: 20337985) Kobi D. … Davidson I. (Pigment Cell Melanoma Res 2010) 3 23
  3. SOX9 and SOX10 but not BRN2 are required for nestin expression in human melanoma cells. (PMID: 18923447) Flammiger A. … Berking C. (J. Invest. Dermatol. 2009) 3 23
  4. Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells. (PMID: 18829533) Goodall J. … Goding C.R. (Cancer Res. 2008) 3 23
  5. Exclusion of mutations in the PRNP, JPH3, TBP, ATN1, CREBBP, POU3F2 and FTL genes as a cause of disease in Portuguese patients with a Huntington-like phenotype. (PMID: 16858508) Costa M.d.o. .C. … Maciel P. (J. Hum. Genet. 2006) 3 23

Products for POU3F2 Gene

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