POU3F2 Gene

Aliases
for POU3F2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC06P099150 GC06P099299 GC06P099328 GC06P099389 GC06P096721

Summaries
for POU3F2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for POU3F2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000006.11  NC_018917.2  NT_025741.16  

SwitchGear Promoter luciferase reporter plasmid: POU3F2 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU3F2

POU3F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P099295:  view genomic region     (about GC identifiers)

Proteins
for POU3F2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for POU3F2: NX_P20265

Explore proteomics data for POU3F2 at MOPED

Post-translational modifications: 

POU3F2 Human Recombinant Protein Products:

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	antibodies-online proteins for POU3F2 (9 products)
	antibodies-online peptides for POU3F2

POU3F2 Antibody Products:

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POU3F2 Assay Products:

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	antibodies-online kits for POU3F2 (6 products)

Domains /
Families
for POU3F2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P20265

Find genes that share domains with POU3F2           About GenesLikeMe

Function
for POU3F2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

(inferred from 3 alleles) (MGI details for Pou3f2)

genOway: Develop your customized and physiologically relevant rodent model for POU3F2

miRNA Products:		miRTarBase miRNAs that target POU3F2: hsa-mir-211-5p (MIRT006355), hsa-let-7a-5p (MIRT052422), hsa-mir-221-3p (MIRT024206)
		Block miRNA regulation of human, mouse, rat POU3F2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate POU3F2 (see all 41):
		hsa-miR-579 hsa-miR-200a hsa-miR-301a hsa-miR-138-2* hsa-miR-1304 hsa-miR-141 hsa-miR-2113 hsa-miR-130b
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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU3F2

Flow Cytometry Products:

eBioscience FlowRNA Probe Sets ( VA4-12794) for POU3F2

Localization
for POU3F2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for POU3F2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for POU3F2 About     See pathways by source

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	SuperPath	Contained pathways About
1	SIDS Susceptibility Pathways	SIDS Susceptibility Pathways
2	Neuroscience	Neuroscience

1 Cell Signaling Technology (CST) Pathway for POU3F2

Neuroscience

1 BioSystems Pathway for POU3F2

SIDS Susceptibility Pathways

Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

Drugs & Compounds
for POU3F2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for POU3F2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for POU3F2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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POU3F2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
Pro-myelinating Schwann Cells Peripheral Nerve Domain
Brain (Nervous System)    fully expand to see all 4 entries
Cerebral Cortex
Oligodendrocyte-like cells
Neural Tube (Nervous System)    fully expand to see all 2 entries
Telencephalon
Floor plate-like cells
Spinal Cord (Nervous System)    fully expand to see all 2 entries
Oligodendrocyte-like cells
Oligodendrocytes (Nervous System)    fully expand to see all 2 entries
Oligodendrocyte-like cells

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU3F2

Orthologs
for POU3F2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for POU3F2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for POU3F2 gene

POU5F2²  POU6F2²  POU4F2²  POU2F3²  POU3F1²  POU3F4²  POU1F1²  POU3F3²  

POU4F3²  POU2F2²  POU5F1B²  POU4F1²  POU2F1²  POU6F1²  POU5F1²  

13 SIMAP similar genes for POU3F2 using alignment to 1 protein entry:     PO3F2_HUMAN:

POU6F1    POU3F4    POU1F1    POU4F3    POU5F1P4    POU3F3

POU5F1    POU3F1    POU2F3    POU5F1P1    POU2F1    POU5F1B

POU2F2

Find genes that share paralogs with POU3F2           About GenesLikeMe

Genomic Variants
for POU3F2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for POU3F2 (see all 98)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1402400611,2		--	99280593(+)	CGCGGA/GTGCGC	1	--	us2k1		0	--	--	--	--
rs132091381,2	C,F	--	99280657(+)	CCTATC/TCATTT	1	--	us2k1		5		NA EA	246
rs1144266991,2	F	--	99280768(+)	AGCCAC/GTCTCC	1	--	us2k1		1		WA	118
rs1857333321,2		--	99280874(+)	CTGAGC/GGTTGA	1	--	us2k1		0	--	--	--	--
rs93729561,2	C	--	99280951(+)	GGACGC/TGATCC	1	--	us2k1		0	--	--	--	--
rs1911481251,2		--	99281157(+)	CGACGC/TGCCCG	1	--	us2k1		0	--	--	--	--
rs1451985751,2		--	99281292(+)	GCCCAC/TCGAAG	1	--	us2k1		0	--	--	--	--
rs119688221,2	C,A,H	--	99281393(+)	CCAGCG/TGTAGG	1	--	us2k1		1		NA	2
rs1169993811,2	F	--	99281405(+)	GCACGG/AGGAAT	1	--	us2k1		1		EA	120
rs132091541,2	C,F	--	99281407(+)	ACGGGC/GAATCG	1	--	us2k1		2		NA	4

HapMap Linkage Disequilibrium report for POU3F2 (99282580 - 99286666 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for POU3F2:    About this table    

Variant ID	Type	Subtype	PubMed ID
dgv6951n71	CNV	Loss	21882294
nsv886433	CNV	Loss	21882294
nsv823787	CNV	Gain	20364138

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing POU3F2

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Disorders / Diseases
for POU3F2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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1 disease for POU3F2

3 Novoseek inferred disease relationships for POU3F2 gene    About this table

Publications
for POU3F2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for POU3F2 gene, integrated from 10 sources (see all 67): (articles sorted by number of sources associating them with POU3F2)

Utopia: connect your pdf to the dynamic world of online information

1. cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif. (PubMed id 8441633)^{1, 2, 3} Schreiber E.... Fontana A. (Nucleic Acids Res. 1993)
2. The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells. (PubMed id 7651733)^{1, 2, 9} Angus J.... Sturm R.A. (Oncogene 1995)
3. Exclusion of mutations in the PRNP, JPH3, TBP, ATN1, CREBBP, POU3F2 and FTL genes as a cause of disease in Portuguese patients with a Huntington-like phenotype. (PubMed id 16858508)^{1, 4, 9} Costa M.d.o. .C....Maciel P. (J. Hum. Genet. 2006)
4. PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival. (PubMed id 10332029)^{1, 2, 9} Waragai M.... Okazawa H. (Hum. Mol. Genet. 1999)
5. A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. (PubMed id 19023125)^{1, 4} Potkin S.G....Macciardi F. (Schizophr Bull 2009)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (Nature 2003)
8. Expression of a large family of POU-domain regulatory genes in mammalian brain development. (PubMed id 2739723)^{1, 2} He X....Rosenfeld M.G. (Nature 1989)
9. Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16. (PubMed id 7601453)^{1, 9} Atanasoski S....Fontana A. (Genomics 1995)
10. SOX9 and SOX10 but not BRN2 are required for nestin expression in human melanoma cells. (PubMed id 18923447)^{1, 9} Flammiger A....Berking C. (J. Invest. Dermatol. 2009)

External Searches for POU3F2 gene

Genome Databases showing POU3F2 gene

Other Databases showing POU3F2 gene

Specialized Databases showing POU3F2 gene

Products
for POU3F2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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