Aliases for POU3F2 Gene
External Ids for POU3F2 Gene
Previous HGNC Symbols for POU3F2 Gene
Previous GeneCards Identifiers for POU3F2 Gene
This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]
GeneCards Summary for POU3F2 Gene
POU3F2 (POU Class 3 Homeobox 2) is a Protein Coding gene. Diseases associated with POU3F2 include Malignant Melanoma, Somatic. Among its related pathways are Neuroscience and SIDS Susceptibility Pathways. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and identical protein binding. An important paralog of this gene is POU3F3.
UniProtKB/Swiss-Prot for POU3F2 Gene
Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, (GCAT) and (TAAT), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity).