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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU3F1 Gene

protein-coding   GIFtS: 54
GCID: GC01M038509

POU Class 3 Homeobox 1

(Previous names: POU domain class 3, transcription factor 1)
(Previous symbol: OTF6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3.2

Aliases
POU Class 3 Homeobox 11 2     POU Domain Transcription Factor SCIP2 3
OTF61 2 3     POU Domain Class 3, Transcription Factor 11
Octamer-Binding Protein 62 3     SCIP2
Octamer-Binding Transcription Factor 62 3     POU Domain, Class 3, Transcription Factor 12
OCT62 3     Oct-63
OTF-62 3     

External Ids:    HGNC: 92141   Entrez Gene: 54532   Ensembl: ENSG000001856687   OMIM: 6024795   UniProtKB: Q030523   
ORGUL members:    fRNAdb10:FR217284 FR044667 FR235515      
NONCODE14:n337877      
RNAdb15:EVF1924 EVF1926 EVF1925    

Export aliases for POU3F1 gene to outside databases

Previous GC identifers: GC01M038434 GC01M037517 GC01M037973 GC01M037923 GC01M038179 GC01M038282 GC01M036628


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for POU3F1 Gene: 
POU3F1 (POU class 3 homeobox 1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with POU3F1 include progressive multifocal leukoencephalopathy, and peripheral neuropathy. GO annotations related to this gene include RNA polymerase II transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO3F1_HUMAN, Q03052
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early
embryogenesis and neurogenesis

Gene Wiki entry for POU3F1 Gene

fRNAdb sequence ontology for POU3F1:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for POU3F1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU3F1 gene promoter:
         NF-1/L   NF-1   GATA-3   SREBP-1c   SREBP-1b   GATA-1   Egr-4   SREBP-1a   HFH-1   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for POU3F1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU3F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

POU3F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU3F1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M038509:  view genomic region     (about GC identifiers)

Start:
38,509,523 bp from pter      End:
38,512,450 bp from pter
Size:
2,928 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for POU3F1

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PO3F1_HUMAN, Q03052 (See protein sequence)
Recommended Name: POU domain, class 3, transcription factor 1  
Size: 451 amino acids; 45496 Da
Subcellular location: Nucleus
Secondary accessions: Q5TAG2

Explore the universe of human proteins at neXtProt for POU3F1: NX_Q03052

Explore proteomics data for POU3F1 at MOPED 

POU3F1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

POU3F1 Protein Expression

REFSEQ proteins: NP_002690.3  
ENSEMBL proteins: 
 ENSP00000362103  

Human Recombinant Protein Products for POU3F1: 
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Novus Biologicals POU3F1 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ISS--
GO:0005667transcription factor complex IEA--

POU3F1 for ontologies           About GeneDecksing



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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
POU: Homeoboxes / POU class

5/7 InterPro protein domains (see all 7):
 IPR010982 Lambda_DNA-bd_dom
 IPR016362 Transcription_factor_POU
 IPR013847 POU
 IPR000327 POU_specific
 IPR017970 Homeobox_CS

Graphical View of Domain Structure for InterPro Entry Q03052

ProtoNet protein and cluster: Q03052

2 Blocks protein domains:
IPB000327 POU domain
IPB013847 POU


UniProtKB/Swiss-Prot: PO3F1_HUMAN, Q03052
Similarity: Belongs to the POU transcription factor family. Class-3 subfamily
Similarity: Contains 1 homeobox DNA-binding domain
Similarity: Contains 1 POU-specific domain


POU3F1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: PO3F1_HUMAN, Q03052
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early
embryogenesis and neurogenesis

     Genatlas biochemistry entry for POU3F1:
POU domain,class 3,transcription factor 1

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001105RNA polymerase II transcription coactivator activity IEA--
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IDA9242494
     
POU3F1 for ontologies           About GeneDecksing


Phenotypes:
     9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Pou3f1):
 behavior/neurological  growth/size  homeostasis/metabolism  integument  mortality/aging 
 nervous system  no phenotypic analysis  normal  respiratory system 

POU3F1 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for POU3F1: Pou3f1tm2.1Mejr Pou3f1tm2Mejr

   inGenious Targeting Laboratory - Custom generated mouse model solutions for POU3F1 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POU3F1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU3F1 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU3F1 

10/338 SABiosciences Target genes for POU3F1 (see all 338):
ACTR3 AGBL2 ALOX15B ANAPC4 ANKS1A AOX2P AP1M1 AP3S2 ARGFX ARID1B

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU3F1
8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate POU3F1 (see all 64):
hsa-miR-323-3p hsa-miR-1224-3p hsa-miR-218-1* hsa-miR-1260b hsa-miR-138-2* hsa-miR-342-3p hsa-miR-502-3p hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmidPOU3F1 3' UTR sequence
Inhib. RNA
Products:
    
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Gene Editing
Products:
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Sirion Biotech Customized adenovirus for overexpression of POU3F1

Clone
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OriGene ORF clones in mouse, rat for POU3F1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: POU3F1 (NM_002699)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU3F1
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                     Customized lentivirus expression plasmids for stable overexpression of POU3F1 

Cell Line
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Search LifeMap BioReagents cell lines for POU3F1
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU3F1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for POU3F1 About                                                                                                See pathways by source

SuperPathContained pathways About
1Transcription factors in neurogenesis
Transcription factors in neurogenesis

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for POU3F1
    Transcription factors in neurogenesis




POU3F1 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU3F1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5 Interacting proteins for POU3F1 (Q030523 ENSP000003621034) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
HMGA1P170963, ENSP000003082274I2D: score=2 STRING: ENSP00000308227
HMGB2P265833, ENSP000002965034I2D: score=1 STRING: ENSP00000296503
POU3F4P493353, ENSP000003622964I2D: score=2 STRING: ENSP00000362296
POU3F2P202653I2D: score=1 
POU3F3P202643I2D: score=1 
About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006355regulation of transcription, DNA-dependent ----
GO:0008366axon ensheathment TAS8662541
GO:0008544epidermis development ----
GO:0010628positive regulation of gene expression ISS--
GO:0014044Schwann cell development ----

POU3F1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POU3F1 (PO3F1)

Search CenterWatch for drugs/clinical trials and news about POU3F1 / PO3F1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
3 fRNAdb Secondary structures:


REFSEQ mRNAs for POU3F1 gene: 
NM_002699.3  

Unigene Cluster for POU3F1:

POU class 3 homeobox 1
Hs.1837  [show with all ESTs]
Unigene Representative Sequence: NM_002699
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000373012(uc001ccp.1)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU3F1
8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate POU3F1 (see all 64):
hsa-miR-323-3p hsa-miR-1224-3p hsa-miR-218-1* hsa-miR-1260b hsa-miR-138-2* hsa-miR-342-3p hsa-miR-502-3p hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmidPOU3F1 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for POU3F1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU3F1
Clone
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OriGene clones in human, mouse for POU3F1 (see all 7)
OriGene ORF clones in mouse, rat for POU3F1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: POU3F1 (NM_002699)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU3F1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU3F1
Sirion Biotech Customized lentivirus for stable overexpression of POU3F1 
                     Customized lentivirus expression plasmids for stable overexpression of POU3F1 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for POU3F1
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POU3F1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU3F1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU3F1

Additional mRNA sequence: 

L26494.1 S81257.1 

3 DOTS entries:

DT.303774  DT.92417853  DT.100697072 

14 AceView cDNA sequences:

CR611990 BE326578 H89079 BF438187 AL565480 AL583550 AI807330 NM_002699 
L26494 AA341505 Z18284 S81257 BQ276805 BU960108 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

POU3F1 expression in normal human tissues (normalized intensities)      POU3F1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAAATATGTG
POU3F1 Expression
About this image


POU3F1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/20 selected tissues (see all 20) fully expand
 
 Brain (Nervous System)    fully expand to see all 11 entries
         Myelinating Oligodendrocyte Cells Forebrain White Matter
         Cerebral Cortex
         N2/LSB/S/F8-induced cells ( Generation of midbrain dopaminergic, forebrain and hypothalamic...
         striatum   
 
 Peripheral Nervous System (Nervous System)    fully expand to see all 4 entries
         Pro-myelinating Schwann Cells Peripheral Nerve Domain
         Schwann cells
         spinal/ganglion/dorsal root ganglion   
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         Retina
         sensory organ/eye/cornea   
 
 Heart (Cardiovascular System)    fully expand to see all 2 entries
         heart/atrium   
 
 Limb (Muscoskeletal System)    fully expand to see all 2 entries
         limb/hindlimb   

See POU3F1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POU3F1

SOURCE GeneReport for Unigene cluster: Hs.1837

UniProtKB/Swiss-Prot: PO3F1_HUMAN, Q03052
Tissue specificity: Expressed in embryonal stem cells and in the developing brain

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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU3F1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU3F1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for POU3F1 gene from 7/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Pou3f11 , 5 POU domain, class 3, transcription factor 11, 5 93.99(n)1
99.33(a)1
  4 (57.86 cM)5
189911  NM_011141.21  NP_035271.11 
 1246568075 
chicken
(Gallus gallus)
Aves POU3F11 POU domain, class 3, transcription factor 1 80.52(n)
78.22(a)
  430270  NM_001031584.1  NP_001026755.1 
lizard
(Anolis carolinensis)
Reptilia POU3F16
POU class 3 homeobox 1
47(a)
1 ↔ 1
GL343202.1(520000-521070)
African clawed frog
(Xenopus laevis)
Amphibia pou1-A2 POU 1 transcription factor 76.91(n)    BC043847.1 
zebrafish
(Danio rerio)
Actinopterygii pou3f11 POU class 3 homeobox 1 69.09(n)
71.22(a)
  30398  NM_131161.1  NP_571236.1 
fruit fly
(Drosophila melanogaster)
Insecta vvl3 peripheral nervous system development
DNA binding
83(a)
(best of 3)
  3 65C5   --
worm
(Caenorhabditis elegans)
Secernentea ceh-63 Homeobox domain, Pou domain -
N-terminal to homeobox more
70(a)   I(8506480-8510320)   --


ENSEMBL Gene Tree for POU3F1 (if available)
TreeFam Gene Tree for POU3F1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for POU3F1 gene
POU5F22  POU6F22  POU4F22  POU2F32  POU3F42  POU1F12  POU3F32  POU4F32  
POU3F22  POU2F22  POU5F1B2  POU4F12  POU2F12  POU6F12  POU5F12  
17 SIMAP similar genes for POU3F1 using alignment to 1 protein entry:     PO3F1_HUMAN:
OCT6    POU2F1    POU6F1    POU1F1    OCT-2    POU4F1
POU3F4    POU2F3    POU4F3    POU2F2    POU3F2    POU3F3
POU5F1    POU5F1P4    POU5F1P1    POU4F2    POU5F1B

POU3F1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/33 SNPs in POU3F1 are shown (see all 33)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1897140351,2
--38509090(+) TGAAAA/GTTGGG 1 -- ds50010--------
rs729308661,2
C--38509157(+) GGGCTG/TCTTTC 1 -- ds50011Minor allele frequency- T:0.50WA 2
rs761652461,2
--38509187(+) GAGTTA/GTGCAT 1 -- ds50010--------
rs1152049831,2
F--38509273(+) TGTCTA/GCGACA 1 -- ds50011Minor allele frequency- G:0.01NA 120
rs1392728951,2
--38509283(+) AGGGGA/GACACG 1 -- ds50010--------
rs2008798581,2
C--38509576(+) CATTA-/TTTTTT 1 -- ut310--------
rs412682511,2
--38509676(+) AAACAC/GAAGAA 1 -- ut310--------
rs284189841,2
C--38509884(+) ATCTCA/CCATAT 1 -- ut312Minor allele frequency- C:0.00NA 4
rs348603891,2
C--38510154(+) GCAGAA/GGCCCC 1 -- ut314Minor allele frequency- G:0.33NA WA EA 360
rs1380249791,2
--38510267(+) TGTTA-/GTTTTT 1 -- ut310--------

HapMap Linkage Disequilibrium report for POU3F1 (38509523 - 38512450 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for POU3F1:    About this table     
Variant IDTypeSubtypePubMed ID
nsv522CNV Insertion18451855

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602479OMIM information:   
9 diseases for POU3F1:    About MalaCards
progressive multifocal leukoencephalopathy    peripheral neuropathy    bipolar disorder    schizophrenia
neuropathy    rheumatoid arthritis    hepatocellular carcinoma    arthritis
neuronitis


POU3F1 for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for POU3F1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia 6.76 2 16246257 (1), 15006499 (1)

Genetic Association Database (GAD): POU3F1

Export disorders for POU3F1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for POU3F1 gene, integrated from 9 sources (see all 44) (see top 10):
(articles sorted by number of sources associating them with POU3F1)
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  1. The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart. (PubMed id 8451175)1, 2, 3 Tobler A.... Fontana A. (1993)
  2. Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia. (PubMed id 7909356)1, 2, 9 Faus I.... Fuchs E. (1994)
  3. Genome-wide association study meta-analysis identifie s seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1, 4 Stahl E.A....Plenge R.M. (2010)
  4. Oct6, a transcription factor controlling myelination, is a marker for active nerve regeneration in peripheral neuropathies. (PubMed id 12557005)1, 9 Kawasaki T....Shibasaki H. (2003)
  5. Expression and activity of the POU transcription factor SCIP. (PubMed id 1975954)1, 9 Monuki E.S....Lemke G. (1990)
  6. Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation. (PubMed id 17195013)1, 9 Beck I.M....Sedlacek R. (2007)
  7. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initia tive SHARe Study. (PubMed id 23192594)1 Velez Edwards D.R....Edwards T.L. (2013)
  8. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
  9. Aberrant CpG island hypermethylation and down-regulat ion of Oct-6 mRNA expression in human hepatocellular carcinoma. (PubMed id 21448695)1 Sun J.Z....Li M. (2011)
  10. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (2007)
  11. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (2007)
  12. Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss. (PubMed id 17959798)1 Ryu E.J....Milbrandt J. (2007)
  13. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
  14. Promyelinating Schwann cells express Tst-1/SCIP/Oct-6. (PubMed id 9742157)1 Arroyo E.J....Scherer S.S. (1998)
  15. Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2. (PubMed id 9457692)1 Sumiyama K....Ueda S. (1998)
  16. Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation. (PubMed id 9242494)1 Andersen B....Rosenfeld M.G. (1997)
  17. The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U. (PubMed id 9105675)1 Malik K.F....Young W.S. (1997)
  18. Identification of the nuclear localization signal of the POU domain protein Tst-1/Oct6. (PubMed id 8663425)1 Sock E....Wegner M. (1996)
  19. The POU factor Oct-6 and Schwann cell differentiation. (PubMed id 8662541)1 Jaegle M....Meijer D. (1996)
  20. High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors. (PubMed id 7720710)1 Zwilling S....Wirth T. (1995)
  21. Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y. (PubMed id 7791781)1 Leger H....Wegner M. (1995)
  22. Expression of transcription regulating genes in human preimplantation embryos. (PubMed id 8567814)1 Abdel-Rahman B.... Pergament E. (1995)
  23. Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain. (PubMed id 1976514)1 Suzuki N....Scholer H.R. (1990)
  24. Down-regulation of the POU transcription factor SCIP is an early event in oligodendrocyte differentiation in vitro. (PubMed id 1483387)9 Collarini E.J....Richardson W.D. (1992)
  25. Identification of genes that are downregulated in the absence of the POU domain transcription factor pou3f1 (Oct-6, Tst-1, SCIP) in sciatic nerve. (PubMed id 12451123)9 Bermingham J.R....Rosenfeld M.G. (2002)
  26. The POU protein Oct-6 is a nucleocytoplasmic shuttling protein. (PubMed id 16260476)9 Baranek C....Wegner M. (2005)
  27. Expression of POU-domain transcription factor, Oct-6, in schizophrenia, bipolar disorder and major depression. (PubMed id 16246257)9 Ubhi K. and Price J. (2005)
  28. The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development. (PubMed id 12782656)9 Jaegle M....Meijer D. (2003)
  29. Gender and age related expression of Oct-6--a POU III domain transcription factor, in the adult mouse brain. (PubMed id 12782346)9 Ilia M....Price J. (2003)
  30. Role of Oct-6 in Schwann cell differentiation. (PubMed id 9672420)9 Jaegle M. and Meijer D. (1998)
  31. Expression of the POU domain transcription factor, Oct-6, is attenuated in the adult mouse telencephalon, but increased by neurotoxic damage. (PubMed id 12781989)9 Ilia M....Price J. (2003)
  32. Transcriptional regulation of the POU gene Oct-6 in Schwann cells. (PubMed id 10635016)9 Mandemakers W....Meijer D. (1999)
  33. Transcriptional control of the neuronal nicotinic acetylcholine receptor gene cluster by the beta43' enhancer, Sp1, SCIP and ETS transcription factors. (PubMed id 10770999)9 Deneris E.S....Yang X. (2000)
  34. Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site. (PubMed id 9528758)9 Ben-Shushan E....Bergman Y. (1998)
  35. Induction of differentiation-regulated transcription factor Oct-6 specifically accompanies major histocompatibility complex class I down-regulation by E1A of oncogenic adenovirus type 12. (PubMed id 8547226)9 Peeper D.S....Zantema A. (1995)
  36. [Progressive multifocal leukoencephalopathy] (PubMed id 9103894)9 Nagashima K. and Ochi H. (1997)
  37. Regulation of human involucrin promoter activity by POU domain proteins. (PubMed id 8663077)9 Welter J.F....Eckert R.L. (1996)
  38. Repression of the myelin P0 gene by the POU transcrip tion factor SCIP. (PubMed id 7690239)9 Monuki E.S....Lemke G. (1993)
  39. Mapping the transactivation domain of the Oct-6 POU transcription factor. (PubMed id 1594443)9 Meijer D....Grosveld G. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5453 HGNC: 9214 AceView: POU3F1 Ensembl:ENSG00000185668 euGenes: HUgn5453
ECgene: POU3F1 H-InvDB: POU3F1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for POU3F1 Pharmacogenomics, SNPs, Pathways

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