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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

POU3F1 Gene

protein-coding GIFtS: 52
GCID: GC01M038509

POU class 3 homeobox 1

(Previous names: POU domain class 3, transcription factor 1 )
(Previous symbol: OTF6)

Explore 10 diseases affiliated with
POU3F1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
POU Class 3 Homeobox 1¹ ²		OTF-6² ³
OCT6¹ ² ³		POU Domain Transcription Factor SCIP² ³
OTF6¹ ² ³		POU Domain Class 3, Transcription Factor 1¹
SCIP¹ ²		POU Domain, Class 3, Transcription Factor 1²
Octamer-Binding Protein 6² ³		Oct-6³
Octamer-Binding Transcription Factor 6² ³

External Ids:	HGNC: 9214¹	Entrez Gene: 5453²	Ensembl: ENSG00000185668⁷	OMIM: 602479⁵	UniProtKB: Q03052³

ORGUL members:
	NONCODE:n337877

Export aliases for POU3F1 gene to outside databases

Previous GC identifers: GC01M038434 GC01M037517 GC01M037973 GC01M037923 GC01M038179 GC01M038282 GC01M036628

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PO3F1_HUMAN, Q03052

Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early

embryogenesis and neurogenesis

Gene Wiki entry for POU3F1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the POU3F1 gene promoter:
NF-1/L NF-1 GATA-3 SREBP-1c SREBP-1b GATA-1 Egr-4 SREBP-1a HFH-1 Ik-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for POU3F1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU3F1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1 Ensembl cytogenetic band: 1p34.3 HGNC cytogenetic band: 1p34.3

POU3F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU3F1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M038509: view genomic region (about GC identifiers)

Start:	38,509,523 bp from pter	End:	38,512,450 bp from pter
Size:	2,928 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PO3F1_HUMAN, Q03052 (See protein sequence)

Recommended Name: POU domain, class 3, transcription factor 1

Size: 451 amino acids; 45496 Da

Subcellular location: Nucleus

Secondary accessions: Q5TAG2

Explore the universe of human proteins at neXtProt for POU3F1: NX_Q03052

POU3F1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002690.3

ENSEMBL proteins:

ENSP00000362103

Human Recombinant Protein Products for POU3F1:

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	Novus Biologicals POU3F1 Lysate
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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005667	transcription factor complex	IEA	--

POU3F1 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

POU3F1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR010982 Lambda_DNA-bd_dom

IPR016362 Transcription_factor_POU

IPR013847 POU

IPR000327 POU_specific

IPR017970 Homeobox_CS

Graphical View of Domain Structure for InterPro Entry Q03052

ProtoNet protein and cluster: Q03052

2 Blocks protein families:

IPB000327 POU domain

IPB013847 POU

UniProtKB/Swiss-Prot: PO3F1_HUMAN, Q03052

Similarity: Belongs to the POU transcription factor family. Class-3 subfamily

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 1 POU-specific domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PO3F1_HUMAN, Q03052

Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early

embryogenesis and neurogenesis

Genatlas biochemistry entry for POU3F1:

POU domain,class 3,transcription factor 1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001105	RNA polymerase II transcription coactivator activity	IEA	--
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	IDA	9242494

POU3F1 for ontologies About GeneDecksing

Phenotypes:
9 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Pou3f1):

behavior/neurological	growth/size	homeostasis/metabolism	integument	mortality/aging
nervous system	no phenotypic analysis	normal	respiratory system

POU3F1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for POU3F1: Pou3f1^tm2.1Mejr Pou3f1^tm2Mejr

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for POU3F1

		10/342 SABiosciences Target genes for POU3F1 (see all 342):
		ACTR3 AGBL2 ALOX15B ANAPC4 ANKS1A AOX2P AP1M1 AP3S2 ARGFX ARID1B

miRNA Products:		OriGene 3'-UTR Clone: POU3F1 Browse MicroRNA Expression Plasmids
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		8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate POU3F1 (see all 64):
		hsa-miR-323-3p hsa-miR-1224-3p hsa-miR-218-1* hsa-miR-1260b hsa-miR-138-2* hsa-miR-342-3p hsa-miR-502-3p hsa-miR-629*

		SwitchGear 3'UTR luciferase reporter plasmid: POU3F1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POU3F1 (see all 7) OriGene shRNA RFP: POU3F1 OriGene siRNA: POU3F1
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU3F1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transcription factors in neurogenesis

Transcription factors in neurogenesis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for POU3F1

Transcription factors in neurogenesis

POU3F1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for POU3F1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5 Interacting proteins for POU3F1 (Q03052³ ENSP00000362103⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HMGA1	P17096³, ENSP00000308227⁴	I2D: score=2 STRING: ENSP00000308227
HMGB2	P26583³, ENSP00000296503⁴	I2D: score=1 STRING: ENSP00000296503
POU3F4	P49335³, ENSP00000362296⁴	I2D: score=2 STRING: ENSP00000362296
POU3F2	P20265³	I2D: score=1
POU3F3	P20264³	I2D: score=1

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	--	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0008366	axon ensheathment	TAS	8662541
GO:0008544	epidermis development	--	--
GO:0010628	positive regulation of gene expression	ISS	--

POU3F1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POU3F1
Search CenterWatch for drugs/clinical trials and news about POU3F1 / PO3F1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for POU3F1 gene:

NM_002699.3

Unigene Cluster for POU3F1:

POU class 3 homeobox 1

Hs.1837 [show with all ESTs]

Unigene Representative Sequence: NM_002699

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000373012(uc001ccp.1)

miRNA Products:		OriGene 3'-UTR Clone: POU3F1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU3F1
		8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate POU3F1 (see all 64):
		hsa-miR-323-3p hsa-miR-1224-3p hsa-miR-218-1* hsa-miR-1260b hsa-miR-138-2* hsa-miR-342-3p hsa-miR-502-3p hsa-miR-629*

		SwitchGear 3'UTR luciferase reporter plasmid: POU3F1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POU3F1 (see all 7) OriGene shRNA RFP: POU3F1 OriGene siRNA: POU3F1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU3F1
		Sirion Biotech Custom design and validation of potent shRNA sequences against POU3F1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POU3F1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POU3F1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: POU3F1 (NM_002699)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU3F1
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU3F1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU3F1

Additional cDNA sequence:

L26494.1 S81257.1

3 DOTS entries:

DT.303774 DT.92417853 DT.100697072

14 AceView cDNA sequences:

CR611990 BE326578 H89079 BF438187 AL583550 AI807330 AL565480 L26494

NM_002699 Z18284 S81257 AA341505 BQ276805 BU960108

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

POU3F1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATATGTG

About this image

POU3F1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

N2/LSB/S/F8-induced cells (Generation of midbra...)

Epiblast-like cells (Reconstitution of mo...)

See POU3F1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POU3F1

SOURCE GeneReport for Unigene cluster: Hs.1837

UniProtKB/Swiss-Prot: PO3F1_HUMAN, Q03052

Tissue specificity: Expressed in embryonal stem cells and in the developing brain

SABiosciences Custom PCR Arrays for POU3F1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU3F1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU3F1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for POU3F1 gene from 17 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chimpanzee (Pan troglodytes)	Mammalia	LOC469287⁶	--	88(a)	1 ↔ 1	1(38282052-38442304)
mouse (Mus musculus)	Mammalia	Pou3f1^{1 , 5}	POU domain, class 3, transcription factor 1^{1, 5}	93.99(n)¹ 99.33(a)¹		4 (57.86 cM)⁵ 18991¹ NM_011141.2¹ NP_035271.1¹ 124656807⁵
rat (Rattus norvegicus)	Mammalia	Pou3f1¹	POU class 3 homeobox 1	93.57(n) 99.33(a)		192110 NM_138838.1 NP_620193.1
cow (Bos taurus)	Mammalia	POU3F1¹	POU class 3 homeobox 1	94.9(n) 99.11(a)		617830 NM_001105451.1 NP_001098921.1
dog (Canis familiaris)	Mammalia	LOC100855694¹	POU domain, class 3, transcription factor 1-like	94.87(n) 98.64(a)		100855694 XM_003639500.1 XP_003639548.1
oppossum (Monodelphis domestica)	Mammalia	POU3F1⁶	Uncharacterized protein	87(a)	1 ↔ 1	4(421718660-421719997)
chicken (Gallus gallus)	Aves	POU3F1¹	POU domain, class 3, transcription factor 1	80.52(n) 78.22(a)		430270 NM_001031584.1 NP_001026755.1
African clawed frog (Xenopus laevis)	Amphibia	pou1-A²	POU 1 transcription factor	76.91(n)		BC043847.1
zebrafish (Danio rerio)	Actinopterygii	pou3f1¹	POU class 3 homeobox 1	69.09(n) 71.22(a)		30398 NM_131161.1 NP_571236.1
sea urchin (Strongylocentrotus purpuratus)	Echinoidea	--	--	34(a)	possible ortholog	scaffold_554(60127-61530)
fruit fly (Drosophila melanogaster)	Insecta	vvl³	peripheral nervous system development DNA binding	83(a) (best of 3)		3 65C5 --
honey bee (Apis mellifera)	Insecta	--	--	35(a)	1 → many	Group10.10(99920-101299)
worm (Caenorhabditis elegans)	Secernentea	ceh-6³	Homeobox domain, Pou domain - N-terminal to homeobox more	70(a)		I(8506480-8510320) --
schistosome parasite (Schistosoma mansoni)	Trematoda	Smp_149570⁶	Pou3/brn-1, putative	15(a)	possible ortholog	Smp_scaff000130(379355-389097)
common water flea (Daphnia pulex)	Crustacea	--	--	83(a)	1 → many	scaffold_86(434292-434795)
Trichoplax (Trichoplax adhaerens)	Tricoplacia	--	--	82(a)	possible ortholog	scaffold_5(3998310-3998762)
sea anemone (Nematostella vectensis)	Anthozoa	-- -- (see all 3)	--	69(a) 64(a) (see all 3)	1 ↔ many possible ortholog (see all 3)	scaffold_262(71949-72503) scaffold_450(6340-6777)

Species with no ortholog for POU3F1

ENSEMBL Gene Tree for POU3F1 (if available)
TreeFam Gene Tree for POU3F1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for POU3F1 gene

POU5F2² POU6F2² POU4F2² POU2F3² POU3F4² POU1F1² POU4F3² POU3F3²

POU3F2² POU2F2² POU5F1B² POU2F1² POU4F1² POU5F1² POU6F1²

17 SIMAP similar genes for POU3F1 using alignment to 1 protein entry: PO3F1_HUMAN:

OCT6 POU2F1 POU6F1 POU1F1 OCT-2 POU4F1

POU3F4 POU2F3 POU4F3 POU2F2 POU3F2 POU3F3

POU5F1 POU5F1P4 POU5F1P1 POU4F2 POU5F1B

POU3F1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189714035^1,2		--	38509090(+)	`TGAAAA/GTTGGG`	1	--	ds500¹		0	--	--	--	--
rs72930866^1,2	C	--	38509157(+)	`GGGCTG/TCTTTC`	1	--	ds500¹		1		WA	2
rs76165246^1,2		--	38509187(+)	`GAGTTA/GTGCAT`	1	--	ds500¹		0	--	--	--	--
rs115204983^1,2		--	38509273(+)	`TGTCTA/GCGACA`	1	--	ds500¹		1		NA	120
rs139272895^1,2		--	38509283(+)	`AGGGGA/GACACG`	1	--	ds500¹		0	--	--	--	--
rs200879858^1,2		--	38509576(+)	`CATTA-/TTTTTT`	1	--	ut3¹		0	--	--	--	--
rs41268251^1,2		--	38509676(+)	`AAACAC/GAAGAA`	1	--	ut3¹		0	--	--	--	--
rs28418984^1,2	C	--	38509884(+)	`ATCTCA/CCATAT`	1	--	ut3¹		2		NA	4
rs34860389^1,2	C	--	38510154(+)	`GCAGAA/GGCCCC`	1	--	ut3¹		4		NA WA EA	360
rs138024979^1,2		--	38510267(+)	`TGTTA-/GTTTTT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for POU3F1 (38509523 - 38512450 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for POU3F1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

POU3F1 for disorders           About GeneDecksing

OMIM gene information: 602479    OMIM disorders: --

10 diseases for POU3F1:    About MalaCards

progressive multifocal leukoencephalopathy peripheral neuropathy bipolar disorder rheumatoid arthritis

neuropathy hepatocellular carcinoma arthritis schizophrenia

carcinoma neuronitis

1 Novoseek disease relationship for POU3F1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia	6.76	2	16246257 (1), 15006499 (1)

Export disorders for POU3F1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for POU3F1 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with POU3F1)

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The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart. (PubMed id 8451175)^{1, 2, 3} Tobler A.... Fontana A. (1993)
Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia. (PubMed id 7909356)^{1, 2, 9} Faus I.... Fuchs E. (1994)
Oct6, a transcription factor controlling myelination, is a marker for active nerve regeneration in peripheral neuropathies. (PubMed id 12557005)^{1, 9} Kawasaki T....Shibasaki H. (2003)
Expression and activity of the POU transcription factor SCIP. (PubMed id 1975954)^{1, 9} Monuki E.S....Lemke G. (1990)
Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation. (PubMed id 17195013)^{1, 9} Beck I.M....Sedlacek R. (2007)
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)¹ Fox C.S....Borecki I.B. (2012)
Aberrant CpG island hypermethylation and down-regulat ion of Oct-6 mRNA expression in human hepatocellular carcinoma. (PubMed id 21448695)¹ Sun J.Z....Li M. (2011)
Genome-wide association study meta-analysis identifie s seven new rheumatoid arthritis risk loci. (PubMed id 20453842)¹ Stahl E.A....Plenge R.M. (2010)
Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss. (PubMed id 17959798)¹ Ryu E.J....Milbrandt J. (2007)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5453	HGNC: 9214	AceView: POU3F1	Ensembl:ENSG00000185668	euGenes: HUgn5453
ECgene: POU3F1	H-InvDB: POU3F1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for POU3F1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for POU3F1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for POU3F1 gene:
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POU class 3 homeobox 1

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