Aliases for POU3F1 Gene
Aliases for POU3F1 Gene
External Ids for POU3F1 Gene
- HGNC: 9214
- Entrez Gene: 5453
- Ensembl: ENSG00000185668
- OMIM: 602479
- UniProtKB: Q03052
Previous HGNC Symbols for POU3F1 Gene
- OTF6
Previous GeneCards Identifiers for POU3F1 Gene
- GC01M038434
- GC01M037517
- GC01M037973
- GC01M037923
- GC01M038179
- GC01M038282
- GC01M038509
- GC01M036628
Summaries for POU3F1 Gene
GeneCards Summary for POU3F1 Gene
POU3F1 (POU Class 3 Homeobox 1) is a Protein Coding gene. Diseases associated with POU3F1 include Neurogenic Bowel and Epidural Abscess. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription coactivator activity. An important paralog of this gene is POU6F1.
UniProtKB/Swiss-Prot for POU3F1 Gene
-
Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Thought to be involved in early embryogenesis and neurogenesis.
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU3F1 Gene
Genomics for POU3F1 Gene
Regulatory Elements for POU3F1 Gene
Enhancers for POU3F1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around POU3F1 on UCSC Golden Path with GeneCards custom track
Promoters for POU3F1 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around POU3F1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for POU3F1 Gene
- Chromosome:
- 1
- Start:
- 38,043,827 bp from pter
- End:
- 38,046,794 bp from pter
- Size:
- 2,968 bases
- Orientation:
- Minus strand
Genomic View for POU3F1 Gene
Genes around POU3F1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.3 by Ensembl
- 1p34.1 by Entrez Gene
- 1p34.3 by HGNC
POU3F1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POU3F1 Gene
Proteins for POU3F1 Gene
-
Protein details for POU3F1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q03052-PO3F1_HUMAN
- Recommended name:
- POU domain, class 3, transcription factor 1
- Protein Accession:
- Q03052
- Q5TAG2
Protein attributes for POU3F1 Gene
- Size:
- 451 amino acids
- Molecular mass:
- 45496 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for POU3F1 Gene
No Post-translational modifications
Other Protein References for POU3F1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for POU3F1
- Novus Biologicals Antibodies for POU3F1
- Invitrogen Antibodies for POU3F1
- antibodies-online Antibodies for POU3F1: See all 52
- GeneTex POU3F1 antibody for POU3F1
-
Santa Cruz Biotechnology (SCBT) Antibodies for POU3F1
Protein Products
-
OriGene Purified Proteins for POU3F1
- Search Origene for MassSpec and Protein Over-expression Lysates for POU3F1
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- Novus Biologicals lysates for POU3F1
- antibodies-online Proteins for POU3F1: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for POU3F1
Assay Products
- antibodies-online Kits for POU3F1: See all 3
No data available for DME Specific Peptides for POU3F1 Gene
Domains & Families for POU3F1 Gene
Gene Families for POU3F1 Gene
Protein Domains for POU3F1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for POU3F1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q03052UniProtKB/Swiss-Prot:
PO3F1_HUMAN :- Contains 1 homeobox DNA-binding domain.
- Belongs to the POU transcription factor family. Class-3 subfamily.
- Domain:
-
- Contains 1 homeobox DNA-binding domain.
- Contains 1 POU-specific domain.
- Family:
-
- Belongs to the POU transcription factor family. Class-3 subfamily.
Function for POU3F1 Gene
Molecular function for POU3F1 Gene
- GENATLAS Biochemistry:
- POU domain,class 3,transcription factor 1
- UniProtKB/Swiss-Prot Function:
- Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Thought to be involved in early embryogenesis and neurogenesis.
Phenotypes for POU3F1 Gene
- GenomeRNAi human phenotypes for POU3F1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for POU3F1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for POU3F1 gene
- Search ViGene Biosciences for POU3F1
CRISPR Products
-
OriGene CRISPR knockouts for POU3F1
-
Santa Cruz Biotechnology (SCBT) CRISPR for POU3F1
- GenScript: Design CRISPR guide RNA sequences for POU3F1
miRNA for POU3F1 Gene
- miRTarBase miRNAs that target POU3F1
-
- hsa-mir-7704 (MIRT488096)
- hsa-mir-6885-5p (MIRT488097)
- hsa-mir-328-5p (MIRT488098)
- hsa-mir-6816-5p (MIRT488099)
- hsa-mir-3196 (MIRT488100)
- hsa-mir-3180-3p (MIRT488101)
- hsa-mir-3180 (MIRT488102)
- hsa-mir-486-3p (MIRT488103)
- hsa-mir-6787-5p (MIRT488104)
- hsa-mir-6721-5p (MIRT488105)
- hsa-mir-663a (MIRT488106)
- hsa-mir-1908-5p (MIRT488107)
- hsa-mir-4763-3p (MIRT488108)
- hsa-mir-1207-5p (MIRT488109)
- hsa-mir-6722-3p (MIRT488110)
- hsa-mir-1909-3p (MIRT488111)
- hsa-mir-4787-5p (MIRT488112)
- hsa-mir-4532 (MIRT488113)
- hsa-mir-4279 (MIRT613911)
- hsa-mir-7111-3p (MIRT613912)
- hsa-mir-6852-3p (MIRT613913)
- hsa-mir-3909 (MIRT613914)
- hsa-mir-6845-3p (MIRT613915)
- hsa-mir-7110-3p (MIRT613916)
- hsa-mir-6769b-3p (MIRT613917)
- hsa-mir-4723-3p (MIRT613918)
- hsa-mir-3183 (MIRT613919)
- hsa-mir-1247-3p (MIRT613920)
- hsa-mir-4531 (MIRT627835)
- hsa-mir-5703 (MIRT627836)
- hsa-mir-4516 (MIRT627837)
- hsa-mir-4434 (MIRT627838)
- hsa-mir-7153-5p (MIRT627839)
- hsa-mir-146b-5p (MIRT627840)
- hsa-mir-146a-5p (MIRT627841)
- hsa-mir-4680-5p (MIRT627842)
Transcription Factor Targets for POU3F1 Gene
Targeted motifs for POU3F1 Gene
HOMER Transcription Factor Regulatory Elements motif POU3F1
- Consensus sequence: WATGCAAATGAG Submotif: canonical Cell Type: NPC GEO ID: GSE35496
miRNA Products
- Search ViGene Biosciences for POU3F1
Clone Products
- OriGene clones in human for POU3F1
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for POU3F1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for POU3F1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for POU3F1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology and Animal Models for POU3F1 Gene
Localization for POU3F1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for POU3F1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
No data available for Gene Ontology (GO) - Cellular Components for POU3F1 Gene
Pathways & Interactions for POU3F1 Gene
More details on SuperPathways for POU3F1
No Data Available
Interacting Proteins for POU3F1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007420 | brain development | IEA | -- |
| GO:0008366 | axon ensheathment | TAS | 8662541 |
| GO:0010628 | positive regulation of gene expression | IEA,ISS | -- |
No data available for Pathways by source and SIGNOR curated interactions for POU3F1 Gene
Transcripts for POU3F1 Gene
mRNA/cDNA for POU3F1 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (14) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for POU3F1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for POU3F1
-
Santa Cruz Biotechnology (SCBT) CRISPR for POU3F1
- GenScript: Design CRISPR guide RNA sequences for POU3F1
miRNA Products
- Search ViGene Biosciences for POU3F1
Clone Products
- OriGene clones in human for POU3F1
- OriGene ORF clones in human,rat for POU3F1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for POU3F1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for POU3F1 Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x9.8), Skin - Sun Exposed (Lower leg) (x9.7), and Nerve - Tibial (x8.2).
SOURCE GeneReport for Unigene cluster for POU3F1 Gene Hs.1837
mRNA Expression by UniProt/SwissProt for POU3F1 Gene
Q03052-PO3F1_HUMAN
Tissue specificity:
Expressed in embryonal stem cells and in the developing brain.
Primer Products
-
OriGene qPCR primer pairs for POU3F1
No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for POU3F1 Gene
Orthologs for POU3F1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | POU3F1 35 |
|
||
| POU3F1 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Pou3f1 35 |
|
||
| dog (Canis familiaris) |
Mammalia | POU3F1 36 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | POU3F1 36 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Pou3f1 36 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | POU3F1 36 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | pou1-A 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pou3f1 36 |
|
ManyToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | nub 37 |
|
|
|
| pdm2 37 |
|
|
|||
| vvl 37 |
|
|
|||
| vvl 36 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | ceh-6 37 |
|
|
- Species with no ortholog for POU3F1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for POU3F1 Gene
Paralogs for POU3F1 Gene
(17) SIMAP similar genes for POU3F1 Gene using alignment to 1 proteins:
Variants for POU3F1 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs7412444 | -- | 38,044,623(+) | ttttt(G/T)GGGGG | utr-variant-3-prime | |
| rs12092034 | -- | 38,043,588(+) | GTCTA(A/G)GAGAG | downstream-variant-500B | |
| rs12092038 | -- | 38,043,591(+) | TAGGA(C/G)AGTCT | downstream-variant-500B | |
| rs28418984 | -- | 38,044,212(+) | ATCTC(A/C)CATAT | utr-variant-3-prime | |
| rs35823623 | -- | 38,044,445(+) | CAGGG(-/G)CCGCG | utr-variant-3-prime |
Gene Damage Index Score:
0.86;
17.98% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for POU3F1 Gene
Disorders for POU3F1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neurogenic bowel |
|
|
| epidural abscess |
|
|
Search POU3F1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for POU3F1
No data available for UniProtKB/Swiss-Prot and Genatlas for POU3F1 Gene
Publications for POU3F1 Gene
- The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart. (PMID: 8451175) Tobler A. … Fontana A. (Nucleic Acids Res. 1993) 2 3 4 67
- Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation. (PMID: 17195013) Beck I.M. … Sedlacek R. (J. Invest. Dermatol. 2007) 3 23
- Oct6, a transcription factor controlling myelination, is a marker for active nerve regeneration in peripheral neuropathies. (PMID: 12557005) Kawasaki T. … Shibasaki H. (Acta Neuropathol. 2003) 3 23
- Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia. (PMID: 7909356) Faus I. … Fuchs E. (Mol. Cell. Biol. 1994) 3 23
- Expression and activity of the POU transcription factor SCIP. (PMID: 1975954) Monuki E.S. … Lemke G. (Science 1990) 3 23
Products for POU3F1 Gene
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- OriGene Purified Proteins for POU3F1
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- OriGene qPCR primer pairs for POU3F1
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- Novus Biologicals Antibodies for POU3F1
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for POU3F1: See all 52
- antibodies-online Kits for POU3F1: See all 3
- antibodies-online Proteins for POU3F1: See all 4
- Search antibodies-online for peptides
- GeneTex POU3F1 antibody for POU3F1
- Search GeneTex for Proteins for POU3F1
- ViGene Biosciences adenoviral particle packaged cDNA for POU3F1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for POU3F1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for POU3F1 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for POU3F1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for POU3F1 gene
- Search ViGene Biosciences for POU3F1
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- Santa Cruz Biotechnology (SCBT) Antibodies for POU3F1
- Search Santa Cruz Biotechnology (SCBT) for POU3F1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for POU3F1
Sources for POU3F1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (24) PharmGKB
- (25) DrugBank
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- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
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- (62) miRBase
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- (64) Nature
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- (68) R&D Systems
- (69) Salk
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- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
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- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
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