Aliases for POU3F1 Gene
Subcategory (RNA class) for POU3F1 Gene
lncRNA
Aliases for POU3F1 Gene
External Ids for POU3F1 Gene
- HGNC: 9214
- Entrez Gene: 5453
- Ensembl: ENSG00000185668
- OMIM: 602479
- UniProtKB: Q03052
ORGUL Members for POU3F1 Gene
-
- RNAdb:
-
- EVF1924
Previous HGNC Symbols for POU3F1 Gene
- OTF6
Previous GeneCards Identifiers for POU3F1 Gene
- GC01M038434
- GC01M037517
- GC01M037973
- GC01M037923
- GC01M038179
- GC01M038282
- GC01M038509
- GC01M036628
Summaries for POU3F1 Gene
GeneCards Summary for POU3F1 Gene
POU3F1 (POU Class 3 Homeobox 1) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with POU3F1 include Neurogenic Bowel. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription coactivator activity. An important paralog of this gene is POU3F3.
UniProtKB/Swiss-Prot for POU3F1 Gene
-
Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Thought to be involved in early embryogenesis and neurogenesis.
fRNAdb sequence ontologies for POU3F1 Gene
-
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for POU3F1 Gene
Genomics for POU3F1 Gene
Regulatory Elements for POU3F1 Gene
Enhancers for POU3F1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G038587 | 1 | Ensembl ENCODE | 9.6 | -540.4 | -540392 | 0.4 | CTCF ESRRA RB1 RAD21 ZNF143 SMC3 ZHX1 ZNF654 TRIM22 REST | POU3F1 ENSG00000224592 MYCBP GJA9 GC01P038607 LOC105378658 |
| GH01G038021 | 0.6 | dbSUPER | 11.8 | +24.4 | 24399 | 1.2 | ATF3 GLIS1 ZNF629 CREB1 ZNF548 ATF2 | INPP5B SF3A3 SNIP1 ENSG00000224592 POU3F1 GNL2 FTH1P1 GC01P038029 UTP11 |
| GH01G038019 | 0.6 | ENCODE dbSUPER | 11.7 | +26.3 | 26282 | 1.0 | PKNOX1 | POU3F1 ENSG00000224592 GC01P038029 UTP11 |
| GH01G038825 | 0.7 | VISTA | 9.8 | -779.5 | -779505 | 0.9 | INSM2 TSHZ1 ZEB2 ZNF2 ATF2 OSR2 PRDM6 ZNF629 SCRT2 FOS | MYCBP GJA9 ENSG00000224592 POU3F1 GC01M038840 PIR38410 GC01P038781 |
| GH01G038152 | 0.6 | ENCODE | 10.6 | -106.1 | -106110 | 0.2 | SRF CTCF PKNOX1 MTA2 BHLHE40 NFYB MNT RAD21 MGA | ENSG00000224592 POU3F1 LOC105378654 LINC01343 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around POU3F1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for POU3F1 Gene
- Chromosome:
- 1
- Start:
- 38,043,851 bp from pter
- End:
- 38,046,794 bp from pter
- Size:
- 2,944 bases
- Orientation:
- Minus strand
Genomic View for POU3F1 Gene
Genes around POU3F1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.3 by Ensembl
- 1p34.3 by Entrez Gene
- 1p34.3 by HGNC
POU3F1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POU3F1 Gene
ORGUL Member Location for POU3F1 Gene
Proteins for POU3F1 Gene
-
Protein details for POU3F1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q03052-PO3F1_HUMAN
- Recommended name:
- POU domain, class 3, transcription factor 1
- Protein Accession:
- Q03052
- Q5TAG2
Protein attributes for POU3F1 Gene
- Size:
- 451 amino acids
- Molecular mass:
- 45496 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for POU3F1 Gene
No Post-translational modifications
Other Protein References for POU3F1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for POU3F1
- Novus Biologicals Antibodies for POU3F1
- Invitrogen Antibodies for POU3F1
- antibodies-online Antibodies for POU3F1: See all 52
- GeneTex POU3F1 antibody for POU3F1
-
Santa Cruz Biotechnology (SCBT) Antibodies for POU3F1
Protein Products
-
OriGene Purified Proteins for POU3F1
- Search Origene for MassSpec and Protein Over-expression Lysates for POU3F1
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- antibodies-online Proteins for POU3F1: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for POU3F1
Assay Products
- antibodies-online Kits for POU3F1: See all 3
No data available for DME Specific Peptides for POU3F1 Gene
Domains & Families for POU3F1 Gene
Gene Families for POU3F1 Gene
Protein Domains for POU3F1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for POU3F1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q03052UniProtKB/Swiss-Prot:
PO3F1_HUMAN :- Belongs to the POU transcription factor family. Class-3 subfamily.
- Family:
-
- Belongs to the POU transcription factor family. Class-3 subfamily.
Function for POU3F1 Gene
Molecular function for POU3F1 Gene
- GENATLAS Biochemistry:
- POU domain,class 3,transcription factor 1
- UniProtKB/Swiss-Prot Function:
- Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Thought to be involved in early embryogenesis and neurogenesis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001105 | RNA polymerase II transcription coactivator activity | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | TAS,IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IDA | 9242494 |
Phenotypes for POU3F1 Gene
- GenomeRNAi human phenotypes for POU3F1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for POU3F1 gene
-
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- Search ViGene Biosciences for POU3F1
CRISPR Products
-
OriGene CRISPR knockouts for POU3F1
-
Santa Cruz Biotechnology (SCBT) CRISPR for POU3F1
- GenScript: Design CRISPR guide RNA sequences for POU3F1
miRNA for POU3F1 Gene
- miRTarBase miRNAs that target POU3F1
-
- hsa-mir-7704 (MIRT488096)
- hsa-mir-6885-5p (MIRT488097)
- hsa-mir-328-5p (MIRT488098)
- hsa-mir-6816-5p (MIRT488099)
- hsa-mir-3196 (MIRT488100)
- hsa-mir-3180-3p (MIRT488101)
- hsa-mir-3180 (MIRT488102)
- hsa-mir-486-3p (MIRT488103)
- hsa-mir-6787-5p (MIRT488104)
- hsa-mir-6721-5p (MIRT488105)
- hsa-mir-663a (MIRT488106)
- hsa-mir-1908-5p (MIRT488107)
- hsa-mir-4763-3p (MIRT488108)
- hsa-mir-1207-5p (MIRT488109)
- hsa-mir-6722-3p (MIRT488110)
- hsa-mir-1909-3p (MIRT488111)
- hsa-mir-4787-5p (MIRT488112)
- hsa-mir-4532 (MIRT488113)
- hsa-mir-4279 (MIRT613911)
- hsa-mir-7111-3p (MIRT613912)
- hsa-mir-6852-3p (MIRT613913)
- hsa-mir-3909 (MIRT613914)
- hsa-mir-6845-3p (MIRT613915)
- hsa-mir-7110-3p (MIRT613916)
- hsa-mir-6769b-3p (MIRT613917)
- hsa-mir-4723-3p (MIRT613918)
- hsa-mir-3183 (MIRT613919)
- hsa-mir-1247-3p (MIRT613920)
- hsa-mir-4531 (MIRT627835)
- hsa-mir-5703 (MIRT627836)
- hsa-mir-4516 (MIRT627837)
- hsa-mir-4434 (MIRT627838)
- hsa-mir-7153-5p (MIRT627839)
- hsa-mir-146b-5p (MIRT627840)
- hsa-mir-146a-5p (MIRT627841)
- hsa-mir-4680-5p (MIRT627842)
Transcription Factor Targets for POU3F1 Gene
Targeted motifs for POU3F1 Gene
HOMER Transcription Factor Regulatory Elements motif POU3F1
- Consensus sequence: WATGCAAATGAG Submotif: canonical Cell Type: NPC GEO ID: GSE35496
miRNA Products
- Search ViGene Biosciences for POU3F1
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for POU3F1 gene
Clone Products
-
OriGene ORF clones in human for POU3F1
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for POU3F1
-
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-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Animal Models for POU3F1 Gene
Localization for POU3F1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for POU3F1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005667 | transcription factor complex | IEA | -- |
Pathways & Interactions for POU3F1 Gene
No Data Available
Interacting Proteins for POU3F1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | IEA | -- |
| GO:0007420 | brain development | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for POU3F1 Gene
Transcripts for POU3F1 Gene
fRNAdb Secondary structures for POU3F1 Gene
mRNA/cDNA for POU3F1 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (14) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for POU3F1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for POU3F1
-
Santa Cruz Biotechnology (SCBT) CRISPR for POU3F1
- GenScript: Design CRISPR guide RNA sequences for POU3F1
miRNA Products
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Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for POU3F1
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-
ViGene Biosciences ready-to-package AAV shRNAs for POU3F1 gene
Clone Products
-
OriGene ORF clones in human for POU3F1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for POU3F1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for POU3F1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for POU3F1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for POU3F1 Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x9.8), Skin - Sun Exposed (Lower leg) (x9.7), and Nerve - Tibial (x8.2).
NURSA nuclear receptor signaling pathways regulating expression of POU3F1 Gene:
POU3F1SOURCE GeneReport for Unigene cluster for POU3F1 Gene:
Hs.1837mRNA Expression by UniProt/SwissProt for POU3F1 Gene:
Q03052-PO3F1_HUMAN
Tissue specificity:
Expressed in embryonal stem cells and in the developing brain.
Evidence on tissue expression from TISSUES for POU3F1 Gene
- Nervous system(2.5)
- Skin(2.1)
Primer Products
-
OriGene qPCR primer pairs for POU3F1
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for POU3F1 Gene
Orthologs for POU3F1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| mouse (Mus musculus) |
Mammalia | Pou3f1 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | POU3F1 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | POU3F1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | POU3F1 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Pou3f1 34 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | POU3F1 35 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | pou1-A 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pou3f1 35 |
|
ManyToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | vvl 36 35 |
|
||
| nub 36 |
|
|
|||
| pdm2 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | ceh-6 36 |
|
|
- Species where no ortholog for POU3F1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for POU3F1 Gene
Paralogs for POU3F1 Gene
(17) SIMAP similar genes for POU3F1 Gene using alignment to 1 proteins:
Variants for POU3F1 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000716740 | -- | 38,043,738(+) | TGAGA(C/T)CAGAA | downstream-variant-500B | |
| rs1000811573 | -- | 38,043,484(+) | TGGGC(G/T)TCTTT | downstream-variant-500B | |
| rs1001456540 | -- | 38,046,914(+) | CGGCC(C/T)CCGCC | intron-variant, upstream-variant-2KB | |
| rs1001537856 | -- | 38,047,511(+) | CTCCG(C/T)CGACC | upstream-variant-2KB, reference, missense | |
| rs1001807722 | -- | 38,043,369(+) | GGGAA(C/T)GGTAA | downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1076389 | CNV | deletion | 25765185 |
| nsv522 | CNV | insertion | 18451855 |
Gene Damage Index Score:
0.86;
17.98% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for POU3F1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- POU3F1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU3F1 Gene
Disorders for POU3F1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neurogenic bowel |
|
|
Search POU3F1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for POU3F1
No data available for UniProtKB/Swiss-Prot and Genatlas for POU3F1 Gene
Publications for POU3F1 Gene
- Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia. (PMID: 7909356) Faus I. … Fuchs E. (Mol. Cell. Biol. 1994) 3 4 22 64
- The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart. (PMID: 8451175) Tobler A. … Fontana A. (Nucleic Acids Res. 1993) 2 3 4 64
- Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PMID: 20453842) Stahl E.A. … Plenge R.M. (Nat. Genet. 2010) 3 46 64
- Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation. (PMID: 17195013) Beck I.M. … Sedlacek R. (J. Invest. Dermatol. 2007) 3 22 64
- Oct6, a transcription factor controlling myelination, is a marker for active nerve regeneration in peripheral neuropathies. (PMID: 12557005) Kawasaki T. … Shibasaki H. (Acta Neuropathol. 2003) 3 22 64
Products for POU3F1 Gene
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- ViGene Biosciences adenoviral particle packaged cDNA for POU3F1 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for POU3F1
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- Horizon Cell Lines for POU3F1
- Cyagen custom Knockout/knockin (KOKI) mouse models for POU3F1
- VectorBuilder custom plasmid, inducible vectors for POU3F1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for POU3F1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for POU3F1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
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