Aliases for POU3F1 Gene
Subcategory (RNA class) for POU3F1 Gene
Aliases for POU3F1 Gene
External Ids for POU3F1 Gene
- HGNC: 9214
- Entrez Gene: 5453
- Ensembl: ENSG00000185668
- OMIM: 602479
- UniProtKB: Q03052
ORGUL Members for POU3F1 Gene
Previous HGNC Symbols for POU3F1 Gene
- OTF6
Previous GeneCards Identifiers for POU3F1 Gene
- GC01M038434
- GC01M037517
- GC01M037973
- GC01M037923
- GC01M038179
- GC01M038282
- GC01M038509
- GC01M036628
Summaries for POU3F1 Gene
GeneCards Summary for POU3F1 Gene
POU3F1 (POU Class 3 Homeobox 1) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with POU3F1 include Neurogenic Bowel. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription coactivator activity. An important paralog of this gene is POU3F3.
UniProtKB/Swiss-Prot for POU3F1 Gene
-
Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Thought to be involved in early embryogenesis and neurogenesis.
fRNAdb sequence ontologies for POU3F1 Gene
-
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.
Additional gene information for POU3F1 Gene
- Monarch Initiative
- Search for POU3F1 at DataMed
- Search for POU3F1 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for POU3F1 Gene
Genomics for POU3F1 Gene
GeneHancer (GH) Regulatory Elements for POU3F1 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01I038046 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 550.8 | -0.2 | -208 | 1.2 | PKNOX1 SIN3A ZNF2 GLIS2 KLF7 KLF13 SP3 NFYC REST ZNF610 | ENSG00000224592 LOC105378653 POU3F1 | |
GH01I038047 | Enhancer | 0.5 | ENCODE | 550.8 | -1.1 | -1140 | 0.2 | SIN3A MIER2 REST EZH2 | ENSG00000224592 LOC105378653 POU3F1 ENSG00000223589 | |
GH01I038587 | Enhancer | 0.9 | Ensembl ENCODE | 9.6 | -540.4 | -540391 | 0.4 | CTCF RB1 BACH1 RAD21 ZNF335 CC2D1A CTBP1 MTA3 ARID2 SMC3 | ENSG00000224592 POU3F1 MYCBP GJA9 GC01P038607 LOC105378658 | |
GH01I038152 | Enhancer | 0.6 | ENCODE | 10.6 | -106.1 | -106110 | 0.2 | CTCF SRF PKNOX1 ZNF687 MNT RAD21 RCOR1 IKZF2 MGA | ENSG00000224592 POU3F1 LOC105378654 LINC01343 | |
GH01I038825 | Enhancer | 0.6 | VISTA | 9.8 | -779.5 | -779505 | 0.9 | INSM2 TSHZ1 ZEB2 ZNF2 ATF2 OSR2 PRDM6 POLR2A ZNF629 SCRT2 | MYCBP GJA9 POU3F1 ENSG00000224592 ENSG00000284632 GC01M038840 PIR38410 |
Regulatory Element Products
Genomic Locations for POU3F1 Gene
- chr1:38,043,851-38,046,794
- (GRCh38/hg38)
- Size:
- 2,944 bases
- Orientation:
- Minus strand
- chr1:38,509,523-38,512,450
- (GRCh37/hg19)
Genomic View for POU3F1 Gene
- Cytogenetic band:
-
- 1p34.3 by Ensembl
- 1p34.3 by Entrez Gene
- 1p34.3 by HGNC


RefSeq DNA sequence for POU3F1 Gene
ORGUL Member Location for POU3F1 Gene

Proteins for POU3F1 Gene
-
Protein details for POU3F1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q03052-PO3F1_HUMAN
- Recommended name:
- POU domain, class 3, transcription factor 1
- Protein Accession:
- Q03052
- Q5TAG2
Protein attributes for POU3F1 Gene
- Size:
- 451 amino acids
- Molecular mass:
- 45496 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for POU3F1 Gene
Other Protein References for POU3F1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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No data available for DME Specific Peptides for POU3F1 Gene
Domains & Families for POU3F1 Gene
Gene Families for POU3F1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for POU3F1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for POU3F1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q03052UniProtKB/Swiss-Prot:
PO3F1_HUMAN :- Belongs to the POU transcription factor family. Class-3 subfamily.
- Family:
-
- Belongs to the POU transcription factor family. Class-3 subfamily.
Function for POU3F1 Gene
Molecular function for POU3F1 Gene
- GENATLAS Biochemistry:
- POU domain,class 3,transcription factor 1
- UniProtKB/Swiss-Prot Function:
- Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Thought to be involved in early embryogenesis and neurogenesis.
Phenotypes From GWAS Catalog for POU3F1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001105 | RNA polymerase II transcription coactivator activity | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA binding transcription factor activity | IEA,TAS | -- |
GO:0043565 | sequence-specific DNA binding | IDA | 9242494 |
Phenotypes for POU3F1 Gene
- GenomeRNAi human phenotypes for POU3F1:
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-
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miRNA for POU3F1 Gene
- miRTarBase miRNAs that target POU3F1
-
- hsa-mir-7704 (MIRT488096)
- hsa-mir-6885-5p (MIRT488097)
- hsa-mir-328-5p (MIRT488098)
- hsa-mir-6816-5p (MIRT488099)
- hsa-mir-3196 (MIRT488100)
- hsa-mir-3180-3p (MIRT488101)
- hsa-mir-3180 (MIRT488102)
- hsa-mir-486-3p (MIRT488103)
- hsa-mir-6787-5p (MIRT488104)
- hsa-mir-6721-5p (MIRT488105)
- hsa-mir-663a (MIRT488106)
- hsa-mir-1908-5p (MIRT488107)
- hsa-mir-4763-3p (MIRT488108)
- hsa-mir-1207-5p (MIRT488109)
- hsa-mir-6722-3p (MIRT488110)
- hsa-mir-1909-3p (MIRT488111)
- hsa-mir-4787-5p (MIRT488112)
- hsa-mir-4532 (MIRT488113)
- hsa-mir-4279 (MIRT613911)
- hsa-mir-7111-3p (MIRT613912)
- hsa-mir-6852-3p (MIRT613913)
- hsa-mir-3909 (MIRT613914)
- hsa-mir-6845-3p (MIRT613915)
- hsa-mir-7110-3p (MIRT613916)
- hsa-mir-6769b-3p (MIRT613917)
- hsa-mir-4723-3p (MIRT613918)
- hsa-mir-3183 (MIRT613919)
- hsa-mir-1247-3p (MIRT613920)
- hsa-mir-4531 (MIRT627835)
- hsa-mir-5703 (MIRT627836)
- hsa-mir-4516 (MIRT627837)
- hsa-mir-4434 (MIRT627838)
- hsa-mir-7153-5p (MIRT627839)
- hsa-mir-146b-5p (MIRT627840)
- hsa-mir-146a-5p (MIRT627841)
- hsa-mir-4680-5p (MIRT627842)
- hsa-mir-129-5p (MIRT783571)
- hsa-mir-3140-3p (MIRT784643)
- hsa-mir-6885-3p (MIRT789317)
Transcription Factor Targets for POU3F1 Gene
Targeted motifs for POU3F1 Gene
- Consensus sequence: WATGCAAATGAG Submotif: canonical Cell Type: NPC GEO ID: GSE35496
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- Yeast expression
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Animal Models for POU3F1 Gene
Localization for POU3F1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for POU3F1 Gene
- Nucleus.
- Nucleoplasm (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | ISS | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005667 | transcription factor complex | IEA | -- |
Pathways & Interactions for POU3F1 Gene
Interacting Proteins for POU3F1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
GO:0006366 | transcription by RNA polymerase II | IEA | -- |
GO:0007420 | brain development | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for POU3F1 Gene
Transcripts for POU3F1 Gene
mRNA/cDNA for POU3F1 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (14) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for POU3F1 Gene
CRISPR Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for POU3F1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for POU3F1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for POU3F1 Gene
NURSA nuclear receptor signaling pathways regulating expression of POU3F1 Gene:
POU3F1SOURCE GeneReport for Unigene cluster for POU3F1 Gene:
Hs.1837mRNA Expression by UniProt/SwissProt for POU3F1 Gene:
Q03052-PO3F1_HUMANEvidence on tissue expression from TISSUES for POU3F1 Gene
- Nervous system(2.5)
- Skin(2.1)
Primer Products
-
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No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for POU3F1 Gene
Orthologs for POU3F1 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
mouse (Mus musculus) |
Mammalia | Pou3f1 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | POU3F1 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | POU3F1 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | POU3F1 34 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Pou3f1 33 |
|
||
chimpanzee (Pan troglodytes) |
Mammalia | POU3F1 34 |
|
OneToOne | |
African clawed frog (Xenopus laevis) |
Amphibia | pou1-A 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | pou3f1 34 |
|
ManyToMany | |
fruit fly (Drosophila melanogaster) |
Insecta | vvl 35 34 |
|
||
nub 35 |
|
|
|||
pdm2 35 |
|
|
|||
worm (Caenorhabditis elegans) |
Secernentea | ceh-6 35 |
|
|
- Species where no ortholog for POU3F1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for POU3F1 Gene
Paralogs for POU3F1 Gene
(17) SIMAP similar genes for POU3F1 Gene using alignment to 1 proteins:
Variants for POU3F1 Gene
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000716740 | -- | 38,043,738(-) | T/C | downstream_transcript_variant | |
rs1000811573 | -- | 38,043,484(-) | T/G | downstream_transcript_variant | |
rs1001456540 | -- | 38,046,914(-) | C/T | upstream_transcript_variant | |
rs1001537856 | -- | 38,047,511(-) | C/T | upstream_transcript_variant | |
rs1001807722 | -- | 38,043,369(-) | T/C | downstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1076389 | CNV | deletion | 25765185 |
nsv522 | CNV | insertion | 18451855 |
Additional Variant Information for POU3F1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- POU3F1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU3F1 Gene
Disorders for POU3F1 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
neurogenic bowel |
|
|
Additional Disease Information for POU3F1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for POU3F1 Gene
Publications for POU3F1 Gene
- Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia. (PMID: 7909356) Faus I … Fuchs E (Molecular and cellular biology 1994) 3 4 22 58
- The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart. (PMID: 8451175) Tobler A … Fontana A (Nucleic acids research 1993) 2 3 4 58
- Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PMID: 20453842) Stahl EA … Plenge RM (Nature genetics 2010) 3 44 58
- Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation. (PMID: 17195013) Beck IM … Sedlacek R (The Journal of investigative dermatology 2007) 3 22 58
- Oct6, a transcription factor controlling myelination, is a marker for active nerve regeneration in peripheral neuropathies. (PMID: 12557005) Kawasaki T … Shibasaki H (Acta neuropathologica 2003) 3 22 58
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- Overview of 79 available POU3F1 gene related products
- genomics-online: primer clones - Search results for 79 available POU3F1 gene related products
- Overview of 79 available POU3F1 gene related products
- genomics-online: shRNA clones - Search results for 79 available POU3F1 gene related products
- Overview of 79 available POU3F1 gene related products
Sources for POU3F1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew