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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU3F1 Gene

protein-coding   GIFtS: 52
GCID: GC01M038509

POU class 3 homeobox 1

(Previous names: POU domain class 3, transcription factor 1 )
(Previous symbol: OTF6)
 Explore 10 diseases affiliated with
POU3F1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for POU3F1    

Aliases
for POU3F1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
POU Class 3 Homeobox 11 2     OTF-62 3
OCT61 2 3     POU Domain Transcription Factor SCIP2 3
OTF61 2 3     POU Domain Class 3, Transcription Factor 11
SCIP1 2     POU Domain, Class 3, Transcription Factor 12
Octamer-Binding Protein 62 3     Oct-63
Octamer-Binding Transcription Factor 62 3     

External Ids:    HGNC: 92141   Entrez Gene: 54532   Ensembl: ENSG000001856687   OMIM: 6024795   UniProtKB: Q030523   
ORGUL members:         
NONCODE:n337877    

Export aliases for POU3F1 gene to outside databases

Previous GC identifers: GC01M038434 GC01M037517 GC01M037973 GC01M037923 GC01M038179 GC01M038282 GC01M036628


Summaries
for POU3F1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: PO3F1_HUMAN, Q03052
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early
embryogenesis and neurogenesis

Gene Wiki entry for POU3F1


Genomic Views
for POU3F1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU3F1 gene promoter:
         NF-1/L   NF-1   GATA-3   SREBP-1c   SREBP-1b   GATA-1   Egr-4   SREBP-1a   HFH-1   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for POU3F1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU3F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

POU3F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU3F1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M038509:  view genomic region     (about GC identifiers)

Start:
 38,509,523 bp from pter      End:
 38,512,450 bp from pter
Size:
 2,928 bases      Orientation:
 minus strand

Proteins
for POU3F1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PO3F1_HUMAN, Q03052 (See protein sequence)
Recommended Name: POU domain, class 3, transcription factor 1  
Size: 451 amino acids; 45496 Da
Subcellular location: Nucleus
Secondary accessions: Q5TAG2

Explore the universe of human proteins at neXtProt for POU3F1: NX_Q03052

POU3F1 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_002690.3  
ENSEMBL proteins: 
 ENSP00000362103  

Human Recombinant Protein Products: 
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OriGene Protein Over-expression Lysate: POU3F1
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Novus Biologicals POU3F1 Lysate
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ISS--
GO:0005667transcription factor complex IEA--


POU3F1 for ontologies           About GeneDecksing



POU3F1 Antibody Products: 
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OriGene Antibodies (see all 2): POU3F1
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Novus Biologicals POU3F1 Antibody
Abcam antibodies for POU3F1 
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GenScript Custom Assay Services for POU3F1
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Browse ELISAs and CLIAs at Uscn

Protein Domains /
Families
for POU3F1 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
POU3F1 for domains           About GeneDecksing

5/7 InterPro domains/families (see all 7):
 IPR010982 Lambda_DNA-bd_dom
 IPR016362 Transcription_factor_POU
 IPR013847 POU
 IPR000327 POU_specific
 IPR017970 Homeobox_CS

Graphical View of Domain Structure for InterPro Entry Q03052

ProtoNet protein and cluster: Q03052

2 Blocks protein families:
IPB000327 POU domain
IPB013847 POU


UniProtKB/Swiss-Prot: PO3F1_HUMAN, Q03052
Similarity: Belongs to the POU transcription factor family. Class-3 subfamily
Similarity: Contains 1 homeobox DNA-binding domain
Similarity: Contains 1 POU-specific domain


Function
for POU3F1 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: PO3F1_HUMAN, Q03052
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early
embryogenesis and neurogenesis

     Genatlas biochemistry entry for POU3F1:
POU domain,class 3,transcription factor 1

10/342 SABiosciences Target genes for POU3F1 (see all 342):
ACTR3 AGBL2 ALOX15B ANAPC4 ANKS1A AOX2P AP1M1 AP3S2 ARGFX ARID1B

miRNA
Products:    		 OriGene 3'-UTR Clone: POU3F1
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU3F1
8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate POU3F1 (see all 64):
hsa-miR-323-3p hsa-miR-1224-3p hsa-miR-218-1* hsa-miR-1260b hsa-miR-138-2* hsa-miR-342-3p hsa-miR-502-3p hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmid: POU3F1 3' UTR sequence
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POU3F1 (see all 7)
OriGene shRNA RFP: POU3F1
OriGene siRNA: POU3F1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU3F1

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for POU3F1

Clone
Products:     		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POU3F1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POU3F1
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU3F1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU3F1 

Cell Line
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Search LifeMap BioReagents cell lines for POU3F1

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU3F1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001105RNA polymerase II transcription coactivator activity IEA--
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IDA9242494


POU3F1 for ontologies           About GeneDecksing


Animal Models:
     Mouse knock-outs for POU3F1: Pou3f1tm2.1Mejr Pou3f1tm2Mejr
     9 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Pou3f1):
 behavior/neurological  growth/size  homeostasis/metabolism  integument  mortality/aging 
 nervous system  no phenotypic analysis  normal  respiratory system 

POU3F1 for phenotypes           About GeneDecksing


Pathways & Interactions
for POU3F1 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Transcription factors in neurogenesis
Transcription factors in neurogenesis1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for POU3F1
    Transcription factors in neurogenesis




POU3F1 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU3F1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5 Interacting proteins for POU3F1 (Q030523 ENSP000003621034) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
HMGA1P170963, ENSP000003082274I2D: score=2 STRING: ENSP00000308227
HMGB2P265833, ENSP000002965034I2D: score=1 STRING: ENSP00000296503
POU3F4P493353, ENSP000003622964I2D: score=2 STRING: ENSP00000362296
POU3F2P202653I2D: score=1 
POU3F3P202643I2D: score=1 
About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-dependent ----
GO:0006355regulation of transcription, DNA-dependent ----
GO:0008366axon ensheathment TAS8662541
GO:0008544epidermis development ----
GO:0010628positive regulation of gene expression ISS--


POU3F1 for ontologies           About GeneDecksing



Drugs & Compounds
for POU3F1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POU3F1
Search CenterWatch for drugs/clinical trials and news about POU3F1 / PO3F1 

Transcripts
for POU3F1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for POU3F1 gene: 
NM_002699.3  

Unigene Cluster for POU3F1:

POU class 3 homeobox 1
Hs.1837  [show with all ESTs]
Unigene Representative Sequence: NM_002699
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000373012(uc001ccp.1)

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU3F1
8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate POU3F1 (see all 64):
hsa-miR-323-3p hsa-miR-1224-3p hsa-miR-218-1* hsa-miR-1260b hsa-miR-138-2* hsa-miR-342-3p hsa-miR-502-3p hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmid: POU3F1 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POU3F1 (see first 1)
NM_002699 (human cat#: TG310274)  NM_011141 (mouse cat#: TF501706)  NM_011141 (mouse cat#: TG501706)  
NM_011141 (mouse cat#: TR501706)  NM_138838 (rat cat#: TF712899)  NM_138838 (rat cat#: TG712899)  NM_138838 (rat cat#: TR712899)  
OriGene shRNA RFP: POU3F1
OriGene siRNA: POU3F1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU3F1
Clone
Products:     		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POU3F1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POU3F1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: POU3F1 (NM_002699)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU3F1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU3F1 
Primer
Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POU3F1
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POU3F1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU3F1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU3F1

Additional cDNA sequence: 

L26494.1 S81257.1 

3 DOTS entries:

DT.303774  DT.92417853  DT.100697072 

14 AceView cDNA sequences:

CR611990 BE326578 H89079 BF438187 AL583550 AI807330 AL565480 L26494 
NM_002699 Z18284 S81257 AA341505 BQ276805 BU960108 

GeneLoc Exon Structure


Expression
for POU3F1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

POU3F1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATATGTG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

POU3F1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
KidneyRenal VesicleKidney
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 2 LifeMap Cells 
NameCategory
N2/LSB/S/F8-induced cells (Generation of midbra...)
Epiblast-like cells (Reconstitution of mo...)

See POU3F1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POU3F1

SOURCE GeneReport for Unigene cluster: Hs.1837

UniProtKB/Swiss-Prot: PO3F1_HUMAN, Q03052
Tissue specificity: Expressed in embryonal stem cells and in the developing brain

    SABiosciences Custom PCR Arrays for POU3F1
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In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU3F1

Orthologs
for POU3F1 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of animals.

Orthologs for POU3F1 gene from 5/17 species (see all 17)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves POU3F11 POU domain, class 3, transcription factor 1 80.52(n)
78.22(a)		   430270  NM_001031584.1  NP_001026755.1 
African clawed frog
(Xenopus laevis)		 Amphibia pou1-A2 POU 1 transcription factor 76.91(n)    BC043847.1 
zebrafish
(Danio rerio)		 Actinopterygii pou3f11 POU class 3 homeobox 1 69.09(n)
71.22(a)		   30398  NM_131161.1  NP_571236.1 
fruit fly
(Drosophila melanogaster)		 Insecta vvl3 peripheral nervous system development DNA
binding		 83(a)
(best of 3)		   3 65C5   --
worm
(Caenorhabditis elegans)		 Secernentea ceh-63 Homeobox domain, Pou domain - N-terminal to
homeobox more		 70(a)   I(8506480-8510320)   --


ENSEMBL Gene Tree for POU3F1 (if available)
TreeFam Gene Tree for POU3F1 (if available) 

Paralogs
for POU3F1 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for POU3F1 gene
POU5F22  POU6F22  POU4F22  POU2F32  POU3F42  POU1F12  POU4F32  POU3F32  
POU3F22  POU2F22  POU5F1B2  POU2F12  POU4F12  POU5F12  POU6F12  
17 SIMAP similar genes for POU3F1 using alignment to 1 protein entry:     PO3F1_HUMAN:
OCT6    POU2F1    POU6F1    POU1F1    OCT-2    POU4F1
POU3F4    POU2F3    POU4F3    POU2F2    POU3F2    POU3F3
POU5F1    POU5F1P4    POU5F1P1    POU4F2    POU5F1B

POU3F1 for paralogs           About GeneDecksing



Genomic Variants
for POU3F1 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/43 NCBI SNPs in POU3F1 are shown (see all 43)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 1 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1897140351,2
--38509090(+) TGAAAA/GTTGGG 1 -- ds50010--------
rs729308661,2
C,--38509157(+) GGGCTG/TCTTTC 1 -- ds50011Minor allele frequency- T:0.50WA 2
rs761652461,2
--38509187(+) GAGTTA/GTGCAT 1 -- ds50010--------
rs1152049831,2
--38509273(+) TGTCTA/GCGACA 1 -- ds50011Minor allele frequency- G:0.01NA 120
rs1392728951,2
--38509283(+) AGGGGA/GACACG 1 -- ds50010--------
rs2008798581,2
--38509576(+) CATTA-/TTTTTT 1 -- ut310--------
rs412682511,2
--38509676(+) AAACAC/GAAGAA 1 -- ut310--------
rs284189841,2
C--38509884(+) ATCTCA/CCATAT 1 -- ut312Minor allele frequency- C:0.00NA 4
rs348603891,2
C,--38510154(+) GCAGAA/GGCCCC 1 -- ut314Minor allele frequency- G:0.33NA WA EA 360
rs1380249791,2
--38510267(+) TGTTA-/GTTTTT 1 -- ut310--------

HapMap Linkage Disequilibrium report for POU3F1 (38509523 - 38512450 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for POU3F1: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POU3F1
DNA2.0 Custom Variant and Variant Library Synthesis for POU3F1

Disorders / Diseases
for POU3F1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
POU3F1 for disorders           About GeneDecksing

OMIM gene information: 602479    OMIM disorders: --

10 diseases for POU3F1:    About MalaCards
progressive multifocal leukoencephalopathy    peripheral neuropathy    bipolar disorder    rheumatoid arthritis
neuropathy    hepatocellular carcinoma    arthritis    schizophrenia
carcinoma    neuronitis

1 Novoseek disease relationship for POU3F1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia 6.76 2 16246257 (1), 15006499 (1)


Export disorders for POU3F1 gene to outside databases

Publications
for POU3F1 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for POU3F1 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with POU3F1)		    Utopia: connect your pdf to the dynamic
world of online information

  1. The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart. (PubMed id 8451175)1, 2, 3 Tobler A.... Fontana A. (1993)
  2. Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia. (PubMed id 7909356)1, 2, 9 Faus I.... Fuchs E. (1994)
  3. Oct6, a transcription factor controlling myelination, is a marker for active nerve regeneration in peripheral neuropathies. (PubMed id 12557005)1, 9 Kawasaki T....Shibasaki H. (2003)
  4. Expression and activity of the POU transcription factor SCIP. (PubMed id 1975954)1, 9 Monuki E.S....Lemke G. (1990)
  5. Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation. (PubMed id 17195013)1, 9 Beck I.M....Sedlacek R. (2007)
  6. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
  7. Aberrant CpG island hypermethylation and down-regulat ion of Oct-6 mRNA expression in human hepatocellular carcinoma. (PubMed id 21448695)1 Sun J.Z....Li M. (2011)
  8. Genome-wide association study meta-analysis identifie s seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1 Stahl E.A....Plenge R.M. (2010)
  9. Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss. (PubMed id 17959798)1 Ryu E.J....Milbrandt J. (2007)
  10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)

External Searches for POU3F1 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Genome Databases showing POU3F1 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5453 HGNC: 9214 AceView: POU3F1 Ensembl:ENSG00000185668 euGenes: HUgn5453
ECgene: POU3F1 H-InvDB: POU3F1

Other Databases showing POU3F1 gene

(According to HUGE)
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Specialized Databases showing POU3F1 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for POU3F1 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for POU3F1 gene

(Patent information from GeneIP,
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IP news from LifeMap Sciences, Inc.)
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Patent Information for POU3F1 gene:
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