POU3F1 Gene

Aliases
for POU3F1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC01M038434 GC01M037517 GC01M037973 GC01M037923 GC01M038179 GC01M038282 GC01M036628

Summaries
for POU3F1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for POU3F1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10  NC_018912.2  NT_032977.10  

Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU3F1

POU3F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M038509:  view genomic region     (about GC identifiers)

Proteins
for POU3F1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for POU3F1: NX_Q03052

Explore proteomics data for POU3F1 at MOPED


See POU3F1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

POU3F1 Human Recombinant Protein Products:

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	antibodies-online peptides for POU3F1

POU3F1 Antibody Products:

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POU3F1 Assay Products:

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	antibodies-online kits for POU3F1 (6 products)

Domains /
Families
for POU3F1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q03052

Find genes that share domains with POU3F1           About GenesLikeMe

Function
for POU3F1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 4 molecular function terms:    About this table

(inferred from 5 alleles) (MGI details for Pou3f1)

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		hsa-miR-323-3p hsa-miR-1224-3p hsa-miR-218-1* hsa-miR-1260b hsa-miR-138-2* hsa-miR-342-3p hsa-miR-502-3p hsa-miR-629*
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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU3F1

Localization
for POU3F1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5
cytosol	2

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for POU3F1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

Drugs & Compounds
for POU3F1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for POU3F1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for POU3F1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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POU3F1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TAAATATGTG

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Peripheral Nervous System (Nervous System)    fully expand to see all 4 entries
Pro-myelinating Schwann Cells Peripheral Nerve Domain
Schwann cells
Schwann-like cells
Schwann Cells (Nervous System)    fully expand to see all 2 entries
Schwann cells
Schwann-like cells
Brain (Nervous System)    fully expand to see all 5 entries
Myelinating Oligodendrocyte Cells Forebrain White Matter
Cerebral Cortex
N2/LSB/S/F8-induced cells
Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
Epiblast Cells Epiblast
Epiblast-like cells
Thymus (Hematopoietic System)
Thymus

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU3F1

Orthologs
for POU3F1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for POU3F1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for POU3F1 gene

POU5F2²  POU6F2²  POU4F2²  POU2F3²  POU3F4²  POU1F1²  POU3F3²  POU4F3²  

POU3F2²  POU2F2²  POU5F1B²  POU4F1²  POU2F1²  POU6F1²  POU5F1²  

17 SIMAP similar genes for POU3F1 using alignment to 1 protein entry:     PO3F1_HUMAN:

OCT6    POU2F1    POU6F1    POU1F1    OCT-2    POU4F1

POU2F3    POU3F4    POU4F3    POU2F2    POU3F2    POU3F3

POU5F1    POU5F1P4    POU5F1P1    POU4F2    POU5F1B

Find genes that share paralogs with POU3F1           About GenesLikeMe

Genomic Variants
for POU3F1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for POU3F1 (see all 33)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1897140351,2		--	38509090(+)	TGAAAA/GTTGGG	1	--	ds5001		0	--	--	--	--
rs729308661,2	C	--	38509157(+)	GGGCTG/TCTTTC	1	--	ds5001		1		WA	2
rs761652461,2		--	38509187(+)	GAGTTA/GTGCAT	1	--	ds5001		0	--	--	--	--
rs1152049831,2	F	--	38509273(+)	TGTCTA/GCGACA	1	--	ds5001		1		NA	120
rs1392728951,2		--	38509283(+)	AGGGGA/GACACG	1	--	ds5001		0	--	--	--	--
rs2008798581,2	C	--	38509576(+)	CATTA-/TTTTTT	1	--	ut31		0	--	--	--	--
rs412682511,2		--	38509676(+)	AAACAC/GAAGAA	1	--	ut31		0	--	--	--	--
rs284189841,2	C	--	38509884(+)	ATCTCA/CCATAT	1	--	ut31		2		NA	4
rs348603891,2	C	--	38510154(+)	GCAGAA/GGCCCC	1	--	ut31		4		NA WA EA	360
rs1380249791,2		--	38510267(+)	TGTTA-/GTTTTT	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for POU3F1 (38509523 - 38512450 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for POU3F1:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv522	CNV	Insertion	18451855

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing POU3F1

DNA2.0 Custom Variant and Variant Library Synthesis for POU3F1

Disorders / Diseases
for POU3F1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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1 disease for POU3F1

1 Novoseek inferred disease relationship for POU3F1 gene    About this table

Publications
for POU3F1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart. (PubMed id 8451175)^{1, 2, 3} Tobler A.... Fontana A. (Nucleic Acids Res. 1993)
2. Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia. (PubMed id 7909356)^{1, 2, 9} Faus I.... Fuchs E. (Mol. Cell. Biol. 1994)
3. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PubMed id 20453842)^{1, 4} Stahl E.A....Plenge R.M. (Nat. Genet. 2010)
4. Oct6, a transcription factor controlling myelination, is a marker for active nerve regeneration in peripheral neuropathies. (PubMed id 12557005)^{1, 9} Kawasaki T....Shibasaki H. (Acta Neuropathol. 2003)
5. Expression and activity of the POU transcription factor SCIP. (PubMed id 1975954)^{1, 9} Monuki E.S....Lemke G. (Science 1990)
6. Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation. (PubMed id 17195013)^{1, 9} Beck I.M....Sedlacek R. (J. Invest. Dermatol. 2007)
7. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. (PubMed id 23192594)¹ Velez Edwards D.R....Edwards T.L. (Hum. Genet. 2013)
8. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)¹ Fox C.S....Borecki I.B. (PLoS Genet. 2012)
9. Aberrant CpG island hypermethylation and down-regulation of Oct-6 mRNA expression in human hepatocellular carcinoma. (PubMed id 21448695)¹ Sun J.Z....Li M. (Dig. Dis. Sci. 2011)
10. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)⁴ Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)

External Searches for POU3F1 gene

Genome Databases showing POU3F1 gene

Other Databases showing POU3F1 gene

Specialized Databases showing POU3F1 gene

Products
for POU3F1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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