POU2F3 Gene
protein-coding GIFtS: 52
GCID: GC11P120144
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POU class 2 homeobox 3(Previous names: POU domain class 2, transcription factor 3 )
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Aliases
for POU2F3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| POU Class 2 Homeobox 31 2 | | OTF-112 3 | | OCT111 2 5 | | PLA12 3 | | Epoc-11 2 | | POU Domain Class 2, Transcription Factor 31 | | PLA-11 2 | | OCT-112 | | Skn-1a1 2 | | POU Domain Transcription Factor OCT11a2 | | Octamer-Binding Protein 112 3 | | POU Domain, Class 2, Transcription Factor 32 | | Octamer-Binding Transcription Factor 112 3 | | OTF113 | | Transcription Factor PLA-12 3 | | Oct-113 | | Transcription Factor Skn-12 3 | | |
Export aliases for POU2F3 gene to outside databasesPrevious GC identifers: GC11P122110 GC11P121622 GC11P119648 GC11P119616 GC11P116050 |
Summaries
for POU2F3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for POU2F3:
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind toa specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein isprimarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. Theencoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may playa role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed forthis gene. (provided by RefSeq, Sep 2011)
UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a numberof genes such as SPRR2A or placental lactogen
Gene Wiki entry for POU2F3
|
Genomic Views
for POU2F3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the POU2F3 gene promoter:
E2F-4 E2F-3a E2F-5 RelA E2F-2 LCR-F1 E2F E2F-1 ZIC2/Zic2 Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for POU2F3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU2F3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3POU2F3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P120144: view genomic region
(about GC identifiers)
Start:
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120,107,349 bp from pter |
End:
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120,190,653 bp from pter |
Size:
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83,305 bases |
Orientation:
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plus strand |
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Proteins
for POU2F3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9 (See
protein sequence)Recommended Name: POU domain, class 2, transcription factor 3 Size: 436 amino acids; 47432 Da
Subcellular location: Nucleus
Secondary accessions: A8K7H8 B4DY07 F5GWW6 Q3MIY3 Q9UKR7 Q9Y504Alternative splicing: 3 isoforms: Q9UKI9-1 Q9UKI9-2 Q9UKI9-3 (Specifically expressed in keratinocytes, induced by high calcium concentration)Explore the universe of human proteins at neXtProt for POU2F3: NX_Q9UKI9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UKI9
POU2F3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001231611.1 NP_055167.2
ENSEMBL proteins: ENSP00000260264 ENSP00000435738 ENSP00000436236 ENSP00000453150 ENSP00000441687
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
POU2F3 for ontologies About GeneDecksing
POU2F3 Antibody Products:
Assay Products for POU2F3: |
Protein
Domains /
Families
for POU2F3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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POU2F3 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9UKI9ProtoNet protein and cluster: Q9UKI9 3 Blocks protein families: IPB000327 POU domain IPB000972 Octamer-binding transcription factor signature IPB013847 POU
UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9Similarity: Belongs to the POU transcription factor family. Class-2 subfamilySimilarity: Contains 1 homeobox DNA-binding domainSimilarity: Contains 1 POU-specific domain |
Function
for POU2F3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a numberof genes such as SPRR2A or placental lactogen
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POU2F3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POU2F3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: POU2F3 (NM_014352) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POU2F3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU2F3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F3 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
POU2F3 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for POU2F3: Pou2f3tm1Rsd Pou2f3tm1Abek
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Pou2f3):
POU2F3 for phenotypes About GeneDecksing
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Pathways & Interactions
for POU2F3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU2F3
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for POU2F3 (Q9UKI93 ENSP000002602644) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
POU2F3 for ontologies About GeneDecksing
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Drugs & Compounds
for POU2F3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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POU2F3 for compounds About GeneDecksing
 Browse Tocris compounds for POU2F3
4 Novoseek chemical compound relationships for POU2F3 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| phospholipid |
26.9 |
3 |
2000640 (2), 2253331 (1) |
| retinoic acid |
2.16 |
1 |
15545507 (1) |
| zinc |
0 |
1 |
8816448 (1) |
| heparin |
0 |
3 |
8485868 (2) |
Search CenterWatch for drugs/clinical trials and news about POU2F3 / PO2F3
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Transcripts
for POU2F3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for POU2F3 gene (2 alternative transcripts): NM_001244682.1 NM_014352.3 Unigene Cluster for POU2F3: POU class 2 homeobox 3 Hs.227115 [show with all ESTs]Unigene Representative Sequence: NM_0143526 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000260264(uc021qrk.1 uc001pxc.3 uc010rzk.2 uc010rzl.2 uc001pxe.1)
ENST00000533620 ENST00000532638 ENST00000532663 ENST00000529039 ENST00000543440
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POU2F3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POU2F3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: POU2F3 (NM_014352) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POU2F3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU2F3 |
Additional cDNA sequence: AF133895.1 AF162278.1 AJ012214.1 AK097382.1 AK291993.1 AK302212.1 BC101649.1 BC143593.1 BC143594.1 BC143595.1 5 DOTS entries: DT.422614 DT.100008374 DT.91731669 DT.100767682 DT.40190810 24/84 AceView cDNA sequences (see all 84): AW361691 CR593728 AW297273 AL531164 BM971471 BU151499 NM_174926 BQ690587 BC015232 CA778080 AI822098 CR602717 AA422067 BQ573722 BX281405 AA341047 CF130410 AF133895 AI804543 BQ719040 BX107785 AK097382 BI546598 AW139181
GeneLoc Exon Structure
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Expression
for POU2F3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| POU2F3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTAGGAAAC
About this image
See POU2F3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POU2F3
SOURCE GeneReport for Unigene cluster: Hs.227115
UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9Tissue specificity: Specifically expressed in epidermis and cultured keratinocytes
SABiosciences Custom PCR Arrays for POU2F3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POU2F3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POU2F3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU2F3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU2F3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F3 |
Orthologs
for POU2F3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for POU2F3 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for POU2F3 (if available)
TreeFam Gene Tree for POU2F3 (if available) |
Paralogs
for POU2F3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for POU2F3 gene
- POU5F22 POU6F22 POU4F22 POU3F42 POU3F12 POU1F12 POU4F32 POU3F32
- POU3F22 POU2F22 POU5F1B2 POU2F12 POU4F12 POU5F12 POU6F12
15 SIMAP similar genes for POU2F3 using alignment to 4 protein entries: PO2F3_HUMAN (see all proteins):OCT6 OCT-2 POU6F1 POU5F1P4 POU2F2 POU1F1
POU2F1 POU3F4 POU3F1 POU5F1P1 POU3F2 POU5F1
POU4F3 POU3F3 POU5F1B
POU2F3 for paralogs About GeneDecksing
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Genomic Variants
for POU2F3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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