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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU2F3 Gene

protein-coding   GIFtS: 52
GCID: GC11P120144

POU class 2 homeobox 3

(Previous names: POU domain class 2, transcription factor 3 )
 Explore 25 diseases affiliated with
POU2F3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for POU2F3    

Aliases
for POU2F3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
POU Class 2 Homeobox 31 2     OTF-112 3
OCT111 2 5     PLA12 3
Epoc-11 2     POU Domain Class 2, Transcription Factor 31
PLA-11 2     OCT-112
Skn-1a1 2     POU Domain Transcription Factor OCT11a2
Octamer-Binding Protein 112 3     POU Domain, Class 2, Transcription Factor 32
Octamer-Binding Transcription Factor 112 3     OTF113
Transcription Factor PLA-12 3     Oct-113
Transcription Factor Skn-12 3     

External Ids:    HGNC: 198641   Entrez Gene: 258332   Ensembl: ENSG000001377097   OMIM: 6073945   UniProtKB: Q9UKI93   

Export aliases for POU2F3 gene to outside databases

Previous GC identifers: GC11P122110 GC11P121622 GC11P119648 GC11P119616 GC11P116050


Summaries
for POU2F3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for POU2F3:
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to
a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is
primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The
encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play
a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for
this gene. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number
of genes such as SPRR2A or placental lactogen

Gene Wiki entry for POU2F3


Genomic Views
for POU2F3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU2F3 gene promoter:
         E2F-4   E2F-3a   E2F-5   RelA   E2F-2   LCR-F1   E2F   E2F-1   ZIC2/Zic2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POU2F3 promoter sequence
   Search SABiosciences Chromatin IP Primers for POU2F3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU2F3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

POU2F3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU2F3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P120144:  view genomic region     (about GC identifiers)

Start:
 120,107,349 bp from pter      End:
 120,190,653 bp from pter
Size:
 83,305 bases      Orientation:
 plus strand

Proteins
for POU2F3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9 (See protein sequence)
Recommended Name: POU domain, class 2, transcription factor 3  
Size: 436 amino acids; 47432 Da
Subcellular location: Nucleus
Secondary accessions: A8K7H8 B4DY07 F5GWW6 Q3MIY3 Q9UKR7 Q9Y504
Alternative splicing: 3 isoforms:  Q9UKI9-1   Q9UKI9-2   Q9UKI9-3   (Specifically expressed in keratinocytes, induced by high calcium concentration)

Explore the universe of human proteins at neXtProt for POU2F3: NX_Q9UKI9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UKI9

    • POU2F3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001231611.1  NP_055167.2  

    ENSEMBL proteins: 
     ENSP00000260264   ENSP00000435738   ENSP00000436236   ENSP00000453150   ENSP00000441687  

    Human Recombinant Protein Products: 
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    Novus Biologicals POU2F3 Protein
    Novus Biologicals POU2F3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for POU2F3

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--


    POU2F3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for POU2F3

    Protein Domains /
    Families
    for POU2F3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    POU2F3 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR000972 TF_octamer
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS

    Graphical View of Domain Structure for InterPro Entry Q9UKI9

    ProtoNet protein and cluster: Q9UKI9

    3 Blocks protein families:
    IPB000327 POU domain
    IPB000972 Octamer-binding transcription factor signature
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9
    Similarity: Belongs to the POU transcription factor family. Class-2 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    Function
    for POU2F3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9
    Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number
    of genes such as SPRR2A or placental lactogen

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU2F3
    32 QIAGEN miScript miRNA Assays for microRNAs that regulate POU2F3 (see first 8):
    hsa-miR-498 hsa-miR-3673 hsa-miR-607 hsa-miR-1271 hsa-miR-128 hsa-miR-450b-3p hsa-miR-3692 hsa-miR-10b*
    hsa-miR-9 hsa-miR-3622b-3p hsa-miR-205* hsa-miR-613 hsa-miR-1299 hsa-miR-96 hsa-miR-577 hsa-miR-3671
    hsa-miR-3163 hsa-miR-206 hsa-miR-27a hsa-miR-3681* hsa-miR-1 hsa-miR-3647-3p hsa-miR-1284 hsa-miR-335
    hsa-miR-146a* hsa-miR-145* hsa-miR-135b hsa-miR-377 hsa-miR-3185 hsa-miR-216a hsa-miR-27b hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmid: POU2F3 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: POU2F3
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU2F3

    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for POU2F3

    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI12624109
    GO:0030528transcription regulator activity ----
    GO:0043565sequence-specific DNA binding IDA9242494


    POU2F3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for POU2F3: Pou2f3tm1Rsd Pou2f3tm1Abek
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pou2f3):
     behavior/neurological  cellular  integument  mortality/aging  taste/olfaction 

    POU2F3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for POU2F3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU2F3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for POU2F3 (Q9UKI93 ENSP000002602644) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    BCL6P411823, ENSP000002320144I2D: score=3 STRING: ENSP00000232014
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10473598
    GO:0008544epidermis development TAS10473598
    GO:0030216keratinocyte differentiation IEA--
    GO:0042060wound healing IEA--


    POU2F3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for POU2F3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POU2F3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POU2F3
    4 Novoseek chemical compound relationships for POU2F3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phospholipid 26.9 3 2000640 (2), 2253331 (1)
    retinoic acid 2.16 1 15545507 (1)
    zinc 0 1 8816448 (1)
    heparin 0 3 8485868 (2)

    Search CenterWatch for drugs/clinical trials and news about POU2F3 / PO2F3 

    Transcripts
    for POU2F3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for POU2F3 gene (2 alternative transcripts): 
    NM_001244682.1  NM_014352.3  

    Unigene Cluster for POU2F3:

    POU class 2 homeobox 3
    Hs.227115  [show with all ESTs]
    Unigene Representative Sequence: NM_014352
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260264(uc021qrk.1 uc001pxc.3 uc010rzk.2 uc010rzl.2 uc001pxe.1)
    ENST00000533620 ENST00000532638 ENST00000532663 ENST00000529039 ENST00000543440


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU2F3
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate POU2F3 (see all 32):
    hsa-miR-498 hsa-miR-3673 hsa-miR-607 hsa-miR-1271 hsa-miR-128 hsa-miR-450b-3p hsa-miR-3692 hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmid: POU2F3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POU2F3 (see all 7)
    OriGene shRNA RFP: POU2F3
    OriGene siRNA: POU2F3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU2F3
    Clone
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    GenScript: all cDNA clones in your preferred vector: POU2F3 (NM_014352)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU2F3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU2F3

    Additional cDNA sequence: 

    AF133895.1 AF162278.1 AJ012214.1 AK097382.1 AK291993.1 AK302212.1 BC101649.1 BC143593.1 
    BC143594.1 BC143595.1 

    5 DOTS entries:

    DT.422614  DT.100008374  DT.91731669  DT.100767682  DT.40190810 

    24/84 AceView cDNA sequences (see all 84):

    AW361691 CR593728 AW297273 AL531164 BM971471 BU151499 NM_174926 BQ690587 
    BC015232 CA778080 AI822098 CR602717 AA422067 BQ573722 BX281405 AA341047 
    CF130410 AF133895 AI804543 BQ719040 BX107785 AK097382 BI546598 AW139181 

    GeneLoc Exon Structure


    Expression
    for POU2F3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU2F3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTAGGAAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See POU2F3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POU2F3

    SOURCE GeneReport for Unigene cluster: Hs.227115

    UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9
    Tissue specificity: Specifically expressed in epidermis and cultured keratinocytes

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F3

    Orthologs
    for POU2F3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for POU2F3 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves POU2F31 POU class 2 homeobox 3 77.73(n)
    80.61(a)    		   428240  XM_425799.3  XP_425799.3 
    lizard
    (Anolis carolinensis)    		 Reptilia POU2F36
    		 --
    		 72(a)
    		 1 ↔ 1
    		 LGa(1316547-1344549)
    zebrafish
    (Danio rerio)    		 Actinopterygii pou2f31 POU class 2 homeobox 3 66.67(n)
    67.35(a)    		   553427  NM_001199683.1  NP_001186612.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta pdm26
    nub6
    		 nubbin
    		 16(a)
    15(a)
    		 many ↔ many
    many ↔ many
    		 2L(12657829-12686313)
    2L(12587871-12628143)
    worm
    (Caenorhabditis elegans)    		 Secernentea ceh-186
    		 Homeobox protein ceh-18
    		 20(a)
    		 1 → many
    		 X(3843808-3857778)


    ENSEMBL Gene Tree for POU2F3 (if available)
    TreeFam Gene Tree for POU2F3 (if available) 

    Paralogs
    for POU2F3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POU2F3 gene
    POU5F22  POU6F22  POU4F22  POU3F42  POU3F12  POU1F12  POU4F32  POU3F32  
    POU3F22  POU2F22  POU5F1B2  POU2F12  POU4F12  POU5F12  POU6F12  
    15 SIMAP similar genes for POU2F3 using alignment to 4 protein entries:     PO2F3_HUMAN (see all proteins):
    OCT6    OCT-2    POU6F1    POU5F1P4    POU2F2    POU1F1
    POU2F1    POU3F4    POU3F1    POU5F1P1    POU3F2    POU5F1
    POU4F3    POU3F3    POU5F1B

    POU2F3 for paralogs           About GeneDecksing



    Genomic Variants
    for POU2F3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1460 NCBI SNPs in POU2F3 are shown (see all 1460)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs79341341,2
    		C,F,H,--116045119(+) TCCCAC/TGNNNN 1 -- us2k113Minor allele frequency- T:0.09NS EA NA WA 1878
    rs798412671,2
    		F,--116045278(+) AACTAG/AGGTTC 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs118233371,2
    		C,H--116045305(+) CTTTGA/GTGGGG 1 -- us2k10--------
    rs9479061,2
    		C,F,A,H,--116045658(+) TGCCGG/TCCTCA 1 -- us2k114Minor allele frequency- T:0.15NS EA NA WA CSA 842
    rs13162811,2
    		--116046685(+) GGTAAG/AGGAGG 1 -- us2k1 trp31Minor allele frequency- A:0.01WA 118
    rs571395841,2
    		C,--116046995(+) TAAAGG/CAGTTC 1 -- int11Minor allele frequency- C:0.50WA 2
    rs603614981,2
    		C,--116047051(+) AAGTCG/TGAGAG 1 -- int11Minor allele frequency- T:0.50WA 2
    rs13206781,2
    		C,F,A,H,--116047216(+) GGGTAA/TGTCCC 1 -- int1 tfbs31Minor allele frequency- T:0.03NA 120
    rs79496841,2
    		C,F,--116047475(+) agtggC/Tactga 1 -- int11Minor allele frequency- T:0.09WA 118
    rs782377821,2
    		C,--116047839(+) AAAACT/CAAAGC 1 -- int13Minor allele frequency- C:0.04WA NA 240

    HapMap Linkage Disequilibrium report for POU2F3 (120107349 - 120190653 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for POU2F3
         2 CNVs: 101355 101354

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    Disorders / Diseases
    for POU2F3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    POU2F3 for disorders           About GeneDecksing

    OMIM gene information: 607394    OMIM disorders: --

    20/25 diseases for POU2F3 (see all 25):    About MalaCards
    cervical cancer    cervicitis    neonatal alloimmune thrombocytopenia    glanzmann's thrombasthenia
    autoimmune thrombocytopenic purpura    cervical intraepithelial neoplasia    herpes simplex    thrombocytopenia
    coronary thrombosis    thrombasthenia    myocardial infarction    purpura
    neuroendocrine tumor    choriocarcinoma    bipolar disorder    thrombosis
    hermaphroditism    hepatocellular carcinoma    breast cancer    atherosclerosis

    2 diseases from the University of Copenhagen DISEASES database for POU2F3:
    Thrombocytopenia     Glanzmann's thrombasthenia

    4 Novoseek disease relationships for POU2F3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 32 1 16005513 (1)
    herpes simplex 2.12 1 7733899 (1)
    thrombocytopenia 0 1 8165025 (1)
    tumors 0 4 16607278 (2), 10077160 (1), 15513931 (1)

    Human Genome Epidemiology (HuGE) Navigator: POU2F3 (1 document)

    Export disorders for POU2F3 gene to outside databases

    Publications
    for POU2F3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU2F3 gene, integrated from 9 sources (see all 90):
    (articles sorted by number of sources associating them with POU2F3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the regulatory domains of the human skn-1a/Epoc- 1/Oct-11 POU transcription factor. (PubMed id 10473598)1, 2, 3 Hildesheim J.... Vogel J.C. (1999)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer. (PubMed id 16607278)1, 9 Zhang Z....Rader J.S. (2006)
    4. Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation. (PubMed id 17195013)1, 9 Beck I.M....Sedlacek R. (2007)
    5. The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression. (PubMed id 16005513)1, 9 Jimenez-Mateo O....Castrillo J.L. (2006)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Relation between the expression levels of the POU tra nscription factors Skn-1a and Skn-1n and keratinocyte differentiation. (PubMed id 21074976)1 Takemoto H....Sawamura D. (2010)
    9. Skn-1a/Oct-11 and I9Np63I+ exert antagonizing effects o n human keratin expression. (PubMed id 20888799)1 Lena A.M....Candi E. (2010)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    External Searches for POU2F3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing POU2F3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25833 HGNC: 19864 AceView: POU2F3andMGC17839 Ensembl:ENSG00000137709 euGenes: HUgn25833
    ECgene: POU2F3 H-InvDB: POU2F3

    Other Databases showing POU2F3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing POU2F3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POU2F3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for POU2F3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for POU2F3 gene:
    Search GeneIP for patents involving POU2F3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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