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POU2F3 Gene

protein-coding   GIFtS: 57
GCID: GC11P120144

POU Class 2 Homeobox 3

(Previous names: POU domain class 2, transcription factor 3)
  See POU2F3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
POU Class 2 Homeobox 31 2     Epoc-12
Octamer-Binding Protein 112 3     OCT-112
Octamer-Binding Transcription Factor 112 3     PLA-12
Transcription Factor PLA-12 3     Skn-1a2
Transcription Factor Skn-12 3     POU Domain Transcription Factor OCT11a2
OTF-112 3     POU Domain, Class 2, Transcription Factor 32
PLA12 3     OTF113
OCT112 5     Oct-113
POU Domain Class 2, Transcription Factor 31     

External Ids:    HGNC: 198641   Entrez Gene: 258332   Ensembl: ENSG000001377097   OMIM: 6073945   UniProtKB: Q9UKI93   

Export aliases for POU2F3 gene to outside databases

Previous GC identifers: GC11P122110 GC11P121622 GC11P119648 GC11P119616 GC11P116050


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POU2F3 Gene:
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors
bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded
protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and
differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter
methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding
multiple isoforms have been observed for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for POU2F3 Gene:
POU2F3 (POU class 2 homeobox 3) is a protein-coding gene. Diseases associated with POU2F3 include cervical cancer, and coronary thrombosis. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a
number of genes such as SPRR2A or placental lactogen

Gene Wiki entry for POU2F3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the POU2F3 gene promoter:
         E2F-4   E2F-3a   E2F-5   RelA   E2F-2   LCR-F1   E2F   E2F-1   ZIC2/Zic2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOU2F3 promoter sequence
   Search Chromatin IP Primers for POU2F3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU2F3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

POU2F3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU2F3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P120144:  view genomic region     (about GC identifiers)

Start:
120,107,349 bp from pter      End:
120,190,653 bp from pter
Size:
83,305 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9 (See protein sequence)
Recommended Name: POU domain, class 2, transcription factor 3  
Size: 436 amino acids; 47432 Da
Secondary accessions: A8K7H8 B4DY07 F5GWW6 Q3MIY3 Q9UKR7 Q9Y504
Alternative splicing: 3 isoforms:  Q9UKI9-1   Q9UKI9-2   Q9UKI9-3   (Specifically expressed in keratinocytes, induced by high calcium concentration)

Explore the universe of human proteins at neXtProt for POU2F3: NX_Q9UKI9

Explore proteomics data for POU2F3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POU2F3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001231611.1  NP_055167.2  

    ENSEMBL proteins: 
     ENSP00000260264   ENSP00000441687   ENSP00000435738   ENSP00000453150  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POU: Homeoboxes / POU class

    Selected InterPro protein domains (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR000972 TF_octamer
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS

    Graphical View of Domain Structure for InterPro Entry Q9UKI9

    ProtoNet protein and cluster: Q9UKI9

    3 Blocks protein domains:
    IPB000327 POU domain
    IPB000972 Octamer-binding transcription factor signature
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9
    Similarity: Belongs to the POU transcription factor family. Class-2 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    Find genes that share domains with POU2F3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO2F3_HUMAN, Q9UKI9
    Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a
    number of genes such as SPRR2A or placental lactogen

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI12624109
    GO:0043565sequence-specific DNA binding IDA9242494
    GO:0046983protein dimerization activity IEA--
         
    Find genes that share ontologies with POU2F3           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pou2f3):
     behavior/neurological  cellular  integument  mortality/aging  taste/olfaction 

    Find genes that share phenotypes with POU2F3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for POU2F3: Pou2f3tm1Rsd Pou2f3tm1Abek

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POU2F3
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    miRNA
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    miRTarBase miRNAs that target POU2F3:
    hsa-mir-26b-5p (MIRT028932), hsa-mir-335-5p (MIRT016830)

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    Selected qRT-PCR Assays for microRNAs that regulate POU2F3 (see all 32):
    hsa-miR-498 hsa-miR-3673 hsa-miR-607 hsa-miR-1271 hsa-miR-128 hsa-miR-450b-3p hsa-miR-3692 hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidPOU2F3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat POU2F3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PO2F3_HUMAN, Q9UKI9: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular2
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with POU2F3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POU2F3 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Herpes simplex infection0.33


    Find genes that share SuperPaths with POU2F3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for POU2F3):
        Herpes simplex infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POU2F3
    Interactions:

        GeneGlobe Interaction Network for POU2F3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for POU2F3 (Q9UKI93 ENSP000002602644) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    BCL6P411823, ENSP000002320144I2D: score=3 STRING: ENSP00000232014
    FAT4ENSP000003778624STRING: ENSP00000377862
    FAT1ENSP000004062294STRING: ENSP00000406229
    FAT3ENSP000003870404STRING: ENSP00000387040
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10473598
    GO:0008544epidermis development TAS10473598
    GO:0030216keratinocyte differentiation IEA--

    Find genes that share ontologies with POU2F3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POU2F3 (PO2F3)

    4 Novoseek inferred chemical compound relationships for POU2F3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phospholipid 26.9 3 2000640 (2), 2253331 (1)
    retinoic acid 2.16 1 15545507 (1)
    zinc 0 1 8816448 (1)
    heparin 0 3 8485868 (2)



    Find genes that share compounds with POU2F3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POU2F3 gene (2 alternative transcripts): 
    NM_001244682.1  NM_014352.3  

    Unigene Cluster for POU2F3:

    POU class 2 homeobox 3
    Hs.227115  [show with all ESTs]
    Unigene Representative Sequence: NM_014352
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260264(uc021qrk.1 uc001pxc.3 uc010rzk.2 uc010rzl.2 uc001pxe.1)
    ENST00000543440 ENST00000533620 ENST00000606153 ENST00000532638 ENST00000532663
    ENST00000529039
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate POU2F3 (see all 32):
    hsa-miR-498 hsa-miR-3673 hsa-miR-607 hsa-miR-1271 hsa-miR-128 hsa-miR-450b-3p hsa-miR-3692 hsa-miR-10b*
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      QuantiFast Probe-based Assays in human, mouse, rat POU2F3

    Additional mRNA sequence: 

    AF133895.1 AF162278.1 AJ012214.1 AK097382.1 AK291993.1 AK302212.1 BC101649.1 BC143593.1 
    BC143594.1 BC143595.1 

    5 DOTS entries:

    DT.422614  DT.100008374  DT.91731669  DT.100767682  DT.40190810 

    Selected AceView cDNA sequences (see all 84):

    AI822098 AA422067 CR602717 AW361691 CR593728 AW297273 BC015232 AL531164 
    BQ690587 CA778080 BQ573722 BX281405 BM971471 NM_174926 BU151499 AA341047 
    BX470406 BU845205 N54103 AL137990 BX107785 NM_014352 BE910031 BM716137 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    POU2F3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTAGGAAAC
    POU2F3 Expression
    About this image


    POU2F3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
    POU2F3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POU2F3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.227115

    UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9
    Tissue specificity: Specifically expressed in epidermis and cultured keratinocytes

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for POU2F3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou2f31 , 5 POU domain, class 2, transcription factor 31, 5 90.05(n)1
    93.01(a)1
      9 (24.21 cM)5
    189881  NM_011139.21  NP_035269.21 
     431239395 
    chicken
    (Gallus gallus)
    Aves POU2F31 POU class 2 homeobox 3 77.51(n)
    80.05(a)
      428240  XM_425799.4  XP_425799.4 
    lizard
    (Anolis carolinensis)
    Reptilia POU2F36
    POU class 2 homeobox 3
    77(a)
    1 ↔ 1
    LGa(1316547-1348136)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pou2f31 POU class 2 homeobox 3 69.59(n)
    72.26(a)
      100490595  XM_002935021.2  XP_002935067.2 
    zebrafish
    (Danio rerio)
    Actinopterygii pou2f31 POU class 2 homeobox 3 66.5(n)
    66.92(a)
      553427  NM_001045255.2  NP_001038720.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta pdm26
    nub6
    nubbin
    18(a)
    17(a)
    many ↔ many
    many ↔ many
    2L(12657829-12686313)
    2L(12587871-12628143)
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-186
    Protein CEH-18, isoform c (ceh-18) mRNA, complete ...
    22(a)
    1 → many
    X(3843379-3857797) WBGene00000441


    ENSEMBL Gene Tree for POU2F3 (if available)
    TreeFam Gene Tree for POU2F3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POU2F3 gene
    POU5F22  POU6F22  POU4F22  POU3F12  POU3F42  POU1F12  POU3F32  POU4F32  
    POU3F22  POU2F22  POU5F1B2  POU4F12  POU2F12  POU6F12  POU5F12  
    13 SIMAP similar genes for POU2F3 using alignment to 3 protein entries:     PO2F3_HUMAN (see all proteins):
    OCT-2    POU6F1    POU2F2    POU5F1P4    POU5F1    POU5F1P1
    POU3F1    POU2F1    POU3F4    POU1F1    POU3F2    POU4F3
    POU3F3

    Find genes that share paralogs with POU2F3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POU2F3 (see all 1710)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349299891,2
    C--116063544(+) TTTTTT/-GAGAT 2 -- int11Minor allele frequency- -:0.50NA 2
    rs113067711,2
    C,F--116071424(+) CATGGT/-TTTTT 2 -- int1 trp34Minor allele frequency- -:0.38NA CSA 8
    rs347003211,2
    C--116073242(+) ATTTAATTT/-  
            
    ATTTA
    2 -- int11Minor allele frequency- -:0.50NA 2
    rs112177781,2
    --116073245(+) TAATTA/TATTTA 2 -- int10--------
    rs1812681141,2
    --116073249(+) TTATTA/TATTTA 2 -- int10--------
    rs1855817381,2
    --116073253(+) TTATTA/TATTTA 2 -- int10--------
    rs105380401,2
    C--116073267(+) attta-/T/    
       TTTAT
    ttatt
    2 -- int11NA 2
    rs1415598411,2
    C--116073267(+) ATTTA-/TTTAT 
            
    TTATT
    2 -- int10--------
    rs351867451,2
    C--116074470(+) CTCAT-/ACAC  
            
    ACACA
    2 -- int10--------
    rs586095711,2
    C--116078392(+) TTAAAGCT/-ACAGG 2 -- cds11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for POU2F3 (120107349 - 120190653 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for POU2F3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2550380CNV Insertion19546169
    esv2612935CNV Insertion19546169
    nsv522706CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POU2F3
    DNA2.0 Custom Variant and Variant Library Synthesis for POU2F3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607394    OMIM disorders: --

    2 diseases for POU2F3 (see first 20):    
    About MalaCards
    cervical cancer    coronary thrombosis

    2 diseases from the University of Copenhagen DISEASES database for POU2F3:
    Thrombocytopenia     Glanzmann's thrombasthenia

    Find genes that share disorders with POU2F3           About GenesLikeMe

    4 Novoseek inferred disease relationships for POU2F3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 32 1 16005513 (1)
    herpes simplex 2.12 1 7733899 (1)
    thrombocytopenia 0 1 8165025 (1)
    tumors 0 4 16607278 (2), 10077160 (1), 15513931 (1)

    Genetic Association Database (GAD): POU2F3
    Human Genome Epidemiology (HuGE) Navigator: POU2F3 (1 document)

    Export disorders for POU2F3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POU2F3 gene, integrated from 10 sources (see all 91):
    (articles sorted by number of sources associating them with POU2F3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the regulatory domains of the human skn-1a/Epoc- 1/Oct-11 POU transcription factor. (PubMed id 10473598)1, 2, 3 Hildesheim J.... Vogel J.C. (J. Biol. Chem. 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer. (PubMed id 16607278)1, 9 Zhang Z....Rader J.S. (Oncogene 2006)
    5. Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation. (PubMed id 17195013)1, 9 Beck I.M....Sedlacek R. (J. Invest. Dermatol. 2007)
    6. The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression. (PubMed id 16005513)1, 9 JimAcnez-Mateo O....Castrillo J.L. (Placenta 2006)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Relation between the expression levels of the POU transcription factors Skn-1a and Skn-1n and keratinocyte differentiation. (PubMed id 21074976)1 Takemoto H....Sawamura D. (J. Dermatol. Sci. 2010)
    10. Skn-1a/Oct-11 and I9Np63I+ exert antagonizing effects on human keratin expression. (PubMed id 20888799)1 Lena A.M....Candi E. (Biochem. Biophys. Res. Commun. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25833 HGNC: 19864 AceView: POU2F3andMGC17839 Ensembl:ENSG00000137709 euGenes: HUgn25833
    ECgene: POU2F3 Kegg: 25833 H-InvDB: POU2F3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POU2F3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POU2F3 gene:
    Search GeneIP for patents involving POU2F3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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