Aliases for POU2F3 Gene
Aliases for POU2F3 Gene
External Ids for POU2F3 Gene
- HGNC: 19864
- Entrez Gene: 25833
- Ensembl: ENSG00000137709
- OMIM: 607394
- UniProtKB: Q9UKI9
Previous GeneCards Identifiers for POU2F3 Gene
- GC11P122110
- GC11P121622
- GC11P120144
- GC11P119648
- GC11P119616
- GC11P116050
Summaries for POU2F3 Gene
-
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for POU2F3 Gene
POU2F3 (POU Class 2 Homeobox 3) is a Protein Coding gene. Diseases associated with POU2F3 include Myocardial Infarction and Blood Coagulation Disease. Among its related pathways are Influenza A. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is POU6F1.
UniProtKB/Swiss-Prot for POU2F3 Gene
-
Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU2F3 Gene
Genomics for POU2F3 Gene
Regulatory Elements for POU2F3 Gene
Enhancers for POU2F3 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around POU2F3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for POU2F3 Gene
- Chromosome:
- 11
- Start:
- 120,236,640 bp from pter
- End:
- 120,319,945 bp from pter
- Size:
- 83,306 bases
- Orientation:
- Plus strand
Genomic View for POU2F3 Gene
Genes around POU2F3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.3 by Ensembl
- 11q23.3 by Entrez Gene
- 11q23.3 by HGNC
POU2F3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POU2F3 Gene
Proteins for POU2F3 Gene
-
Protein details for POU2F3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UKI9-PO2F3_HUMAN
- Recommended name:
- POU domain, class 2, transcription factor 3
- Protein Accession:
- Q9UKI9
- A8K7H8
- B4DY07
- F5GWW6
- Q3MIY3
- Q9UKR7
- Q9Y504
Protein attributes for POU2F3 Gene
- Size:
- 436 amino acids
- Molecular mass:
- 47432 Da
- Quaternary structure:
- No Data Available
Protein Expression for POU2F3 Gene
Post-translational modifications for POU2F3 Gene
Other Protein References for POU2F3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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- GeneTex POU2F3 antibody for POU2F3
-
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-
Santa Cruz Biotechnology (SCBT) Antibodies for POU2F3
Protein Products
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OriGene Purified Proteins for POU2F3
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- antibodies-online Proteins for POU2F3: See all 7
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Assay Products
- antibodies-online Kits for POU2F3: See all 2
No data available for DME Specific Peptides for POU2F3 Gene
Domains & Families for POU2F3 Gene
Gene Families for POU2F3 Gene
Protein Domains for POU2F3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for POU2F3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UKI9UniProtKB/Swiss-Prot:
PO2F3_HUMAN :- Contains 1 homeobox DNA-binding domain.
- Belongs to the POU transcription factor family. Class-2 subfamily.
- Domain:
-
- Contains 1 homeobox DNA-binding domain.
- Contains 1 POU-specific domain.
- Family:
-
- Belongs to the POU transcription factor family. Class-2 subfamily.
Function for POU2F3 Gene
Molecular function for POU2F3 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | IMP | 12624109 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IEA,IDA | 9242494 |
Phenotypes for POU2F3 Gene
- MGI mutant phenotypes for POU2F3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for POU2F3:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased ionizing radiation sensitivity
- Decreased shRNA abundance (Z-score < -2)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after Maraba virus infection
Animal Model Products
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-
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CRISPR Products
-
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-
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miRNA for POU2F3 Gene
- miRTarBase miRNAs that target POU2F3
-
- hsa-mir-335-5p (MIRT016830)
- hsa-mir-26b-5p (MIRT028932)
- hsa-mir-3620-5p (MIRT622639)
- hsa-mir-1587 (MIRT622640)
- hsa-mir-7703 (MIRT622641)
- hsa-mir-6720-5p (MIRT622642)
- hsa-mir-6512-3p (MIRT622643)
- hsa-mir-4741 (MIRT622644)
- hsa-mir-4675 (MIRT622645)
- hsa-mir-762 (MIRT622646)
- hsa-mir-5001-5p (MIRT622647)
- hsa-mir-4498 (MIRT622648)
- hsa-mir-4492 (MIRT622649)
- hsa-mir-6829-5p (MIRT622650)
- hsa-mir-4656 (MIRT622651)
- hsa-mir-4430 (MIRT622652)
- hsa-mir-3652 (MIRT622653)
- hsa-mir-6081 (MIRT622654)
- hsa-mir-3135b (MIRT622655)
- hsa-mir-661 (MIRT622656)
- hsa-mir-378g (MIRT622657)
- hsa-mir-766-3p (MIRT622658)
- hsa-mir-939-3p (MIRT622659)
- hsa-mir-6849-3p (MIRT622660)
- hsa-mir-508-5p (MIRT622661)
- hsa-mir-3679-3p (MIRT649933)
- hsa-mir-5681b (MIRT649934)
- hsa-mir-6832-3p (MIRT649935)
- hsa-mir-4252 (MIRT666861)
- hsa-mir-4793-3p (MIRT666862)
- hsa-mir-1273g-3p (MIRT666863)
- hsa-mir-7977 (MIRT672454)
- hsa-mir-24-3p (MIRT672455)
- hsa-mir-4284 (MIRT672456)
- hsa-mir-4755-3p (MIRT672457)
- hsa-mir-342-3p (MIRT672458)
- hsa-mir-1972 (MIRT672459)
- hsa-mir-5685 (MIRT672460)
- hsa-mir-4690-3p (MIRT672461)
- hsa-mir-1228-3p (MIRT672462)
- hsa-mir-5694 (MIRT696230)
miRNA Products
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Clone Products
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Cell Line Products
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POU2F3 Gene
Localization for POU2F3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for POU2F3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| extracellular | 2 |
| lysosome | 1 |
| plasma membrane | 1 |
| vacuole | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | -- |
Pathways & Interactions for POU2F3 Gene
More details on SuperPathways for POU2F3| Superpath | Contained pathways | |
|---|---|---|
| 1 | Influenza A |
Pathways by source for POU2F3 Gene
1 KEGG pathway for POU2F3 Gene
Interacting Proteins for POU2F3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for SIGNOR curated interactions for POU2F3 Gene
Transcripts for POU2F3 Gene
mRNA/cDNA for POU2F3 Gene
- (7) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (84) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for POU2F3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for POU2F3
-
Santa Cruz Biotechnology (SCBT) CRISPR for POU2F3
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miRNA Products
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Clone Products
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Flow Cytometry Products
Expression for POU2F3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for POU2F3 Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x21.9) and Skin - Not Sun Exposed (Suprapubic) (x21.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POU2F3 Gene
SOURCE GeneReport for Unigene cluster for POU2F3 Gene Hs.227115
mRNA Expression by UniProt/SwissProt for POU2F3 Gene
Q9UKI9-PO2F3_HUMAN
Tissue specificity:
Specifically expressed in epidermis and cultured keratinocytes.
Primer Products
-
OriGene qPCR primer pairs for POU2F3
No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for POU2F3 Gene
Orthologs for POU2F3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | POU2F3 35 |
|
||
| POU2F3 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | POU2F3 35 |
|
||
| POU2F3 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Pou2f3 35 |
|
||
| Pou2f3 16 |
|
||||
| Pou2f3 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | POU2F3 35 |
|
||
| POU2F3 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Pou2f3 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | POU2F3 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | POU2F3 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | POU2F3 35 |
|
||
| POU2F3 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | POU2F3 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pou2f3 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pou2f3 35 |
|
||
| pou2f3 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | nub 36 |
|
ManyToMany | |
| pdm2 36 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | ceh-18 36 |
|
OneToMany |
- Species with no ortholog for POU2F3:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for POU2F3 Gene
Paralogs for POU2F3 Gene
(13) SIMAP similar genes for POU2F3 Gene using alignment to 3 proteins:
Variants for POU2F3 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs7110845 | - | 120,305,040(+) | TGGGC(A/G/T)CCCTG | nc-transcript-variant, reference, missense | |
| rs2282537 | - | 120,317,262(-) | AAGGC(C/T)TGCTG | reference, missense | |
| rs717051 | -- | 120,309,948(-) | TTCTC(A/G)TTCTG | intron-variant | |
| rs717052 | -- | 120,309,770(-) | CTCTA(C/T)TGAAA | intron-variant | |
| rs744983 | -- | 120,295,649(-) | TTCCA(C/T)ATCCT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2612935 | CNV | Insertion | 19546169 |
| esv2550380 | CNV | Insertion | 19546169 |
| nsv522706 | CNV | Loss | 19592680 |
Residual Variation Intolerance Score:
50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.40;
85.54% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for POU2F3 Gene
Disorders for POU2F3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myocardial infarction |
|
|
| blood coagulation disease |
|
|
Search POU2F3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for POU2F3
No data available for UniProtKB/Swiss-Prot and Genatlas for POU2F3 Gene
Publications for POU2F3 Gene
- Characterization of the regulatory domains of the human skn-1a/Epoc- 1/Oct-11 POU transcription factor. (PMID: 10473598) Hildesheim J. … Vogel J.C. (J. Biol. Chem. 1999) 2 3 4 67
- Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation. (PMID: 17195013) Beck I.M. … Sedlacek R. (J. Invest. Dermatol. 2007) 3 23
- The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression. (PMID: 16005513) JimAcnez-Mateo O. … Castrillo J.L. (Placenta 2006) 3 23
- Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer. (PMID: 16607278) Zhang Z. … Rader J.S. (Oncogene 2006) 3 23
- The I'-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3. (PMID: 25178105) Neumann C. … Bigliardi P.L. (J. Invest. Dermatol. 2015) 3
Products for POU2F3 Gene
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- ViGene Biosciences adenoviral particle packaged cDNA for POU2F3 gene
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Sources for POU2F3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
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- (15) Blocks
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- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
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- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
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- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
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- (50) BGMUT
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- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
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- (64) Nature
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- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
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- (86) SPIRE
- (87) neXtProt
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- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
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