POU2F3 Gene

Aliases
for POU2F3 gene

Previous GC identifers: GC11P122110 GC11P121622 GC11P119648 GC11P119616 GC11P116050

Summaries
for POU2F3 gene

Genomic Views
for POU2F3 gene

RefSeq DNA sequence:

NC_000011.9  NC_018922.2  NT_033899.8  

SwitchGear Promoter luciferase reporter plasmid: POU2F3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU2F3

POU2F3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P120144:  view genomic region     (about GC identifiers)

Proteins
for POU2F3 gene

Explore the universe of human proteins at neXtProt for POU2F3: NX_Q9UKI9

Explore proteomics data for POU2F3 at MOPED 

Post-translational modifications:

POU2F3 Protein expression data from MOPED¹, PaxDb² and MAXQB³ 

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Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

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Protein Domains /
Families
for POU2F3 gene

ProtoNet protein and cluster: Q9UKI9

POU2F3 for domains           About GeneDecksing

Function
for POU2F3 gene

     Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Pou2f3)

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		hsa-miR-498 hsa-miR-3673 hsa-miR-607 hsa-miR-1271 hsa-miR-128 hsa-miR-450b-3p hsa-miR-3692 hsa-miR-10b*
		SwitchGear 3'UTR luciferase reporter plasmid: POU2F3 3' UTR sequence

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Pathways & Interactions
for POU2F3 gene

	SuperPath	Contained pathways About
1	Influenza A	Herpes simplex infection 0.33

1         Kegg Pathway  (Kegg details for POU2F3)

Herpes simplex infection

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

Drugs & Compounds
for POU2F3 gene

Transcripts
for POU2F3 gene

Expression
for POU2F3 gene

POU2F3 expression in normal human tissues (normalized intensities)      POU2F3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TCTAGGAAAC

About this image

Inner Cell Mass (Early Embryonic Tissues)
Line H9 (WA09)
Brain (Nervous System)
Trigeminal Ganglion
Colon (Gastrointestinal Tract)
-- (Integumentary System)
skin

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F3

Orthologs
for POU2F3 gene

Paralogs
for POU2F3 gene

Paralogs for POU2F3 gene

POU5F2²  POU6F2²  POU4F2²  POU3F1²  POU3F4²  POU1F1²  POU3F3²  POU4F3²  

POU3F2²  POU2F2²  POU5F1B²  POU4F1²  POU2F1²  POU6F1²  POU5F1²  

14 SIMAP similar genes for POU2F3 using alignment to 4 protein entries:     PO2F3_HUMAN (see all proteins):

OCT6    OCT-2    POU6F1    POU5F1P4    POU2F2    POU1F1

POU2F1    POU3F4    POU3F1    POU5F1P1    POU3F2    POU5F1

POU4F3    POU3F3

POU2F3 for paralogs           About GeneDecksing

Genomic Variants
for POU2F3 gene

10/1710 SNPs in POU2F3 are shown (see all 1710)    About this table     

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs349299891,2	C	--	116063544(+)	TTTTTT/-GAGAT	2	--	int1		1		NA	2
rs113067711,2	C,F	--	116071424(+)	CATGGT/-TTTTT	2	--	int1 trp3		4		NA CSA	8
rs347003211,2	C	--	116073242(+)	ATTTAATTT/-           ATTTA	2	--	int1		1		NA	2
rs112177781,2		--	116073245(+)	TAATTA/TATTTA	2	--	int1		0	--	--	--	--
rs1812681141,2		--	116073249(+)	TTATTA/TATTTA	2	--	int1		0	--	--	--	--
rs1855817381,2		--	116073253(+)	TTATTA/TATTTA	2	--	int1		0	--	--	--	--
rs105380401,2	C	--	116073267(+)	attta-/T/        TTTATttatt	2	--	int1		1		NA	2
rs1415598411,2	C	--	116073267(+)	ATTTA-/TTTAT          TTATT	2	--	int1		0	--	--	--	--
rs351867451,2	C	--	116074470(+)	CTCAT-/ACAC           ACACA	2	--	int1		0	--	--	--	--
rs586095711,2	C	--	116078392(+)	TTAAAGCT/-ACAGG	2	--	cds1		1		CSA	2

HapMap Linkage Disequilibrium report for POU2F3 (120107349 - 120190653 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for POU2F3:    About this table     

Variant ID	Type	Subtype	PubMed ID
esv2550380	CNV	Insertion	19546169
esv2612935	CNV	Insertion	19546169
nsv522706	CNV	Loss	19592680

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SeqTarget long-range PCR primers for resequencing POU2F3

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Disorders / Diseases
for POU2F3 gene

20/24 diseases for POU2F3

4 Novoseek inferred disease relationships for POU2F3 gene    About this table

Publications
for POU2F3 gene

PubMed articles for POU2F3 gene, integrated from 9 sources (see all 91) (see top 10): (articles sorted by number of sources associating them with POU2F3)

Utopia: connect your pdf to the dynamic world of online information

1. Characterization of the regulatory domains of the human skn-1a/Epoc- 1/Oct-11 POU transcription factor. (PubMed id 10473598)^{1, 2, 3} Hildesheim J.... Vogel J.C. (1999)
2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
4. Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer. (PubMed id 16607278)^{1, 9} Zhang Z....Rader J.S. (2006)
5. Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation. (PubMed id 17195013)^{1, 9} Beck I.M....Sedlacek R. (2007)
6. The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression. (PubMed id 16005513)^{1, 9} Jimenez-Mateo O....Castrillo J.L. (2006)
7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (2012)
8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
9. Relation between the expression levels of the POU tra nscription factors Skn-1a and Skn-1n and keratinocyte differentiation. (PubMed id 21074976)¹ Takemoto H....Sawamura D. (2010)
10. Skn-1a/Oct-11 and I9Np63I+ exert antagonizing effects o n human keratin expression. (PubMed id 20888799)¹ Lena A.M....Candi E. (2010)
11. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
12. Transcription factor human Skn-1a enhances replication of human papillomavirus DNA through the direct binding to two sites near the viral replication origin. (PubMed id 18479461)¹ Kukimoto I....Kanda T. (2008)
13. Identification of Skn-1n, a splice variant induced by high calcium concentration and specifically expressed in normal human keratinocytes. (PubMed id 17989732)¹ Nakajima K....Sawamura D. (2008)
14. Large-scale identification of human genes implicated in epidermal barrier function. (PubMed id 17562024)¹ Toulza E.... Guerrin M. (2007)
15. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
16. Analysis of BCL6-interacting proteins by tandem mass spectrometry. (PubMed id 16147992)¹ Miles R.R....Elenitoba-Johnson K.S. (2005)
17. Keratinocyte-specific POU transcription factor hSkn-1a represses the growth of cervical cancer cell lines. (PubMed id 15077167)¹ Enomoto Y....Kanda T. (2004)
18. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
19. Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation. (PubMed id 12624109)¹ Cabral A.... Backendorf C. (2003)
20. A promoter within the E6 ORF of human papillomavirus type 16 contributes to the expression of the E7 oncoprotein from a monocistroni c mRNA. (PubMed id 14645924)¹ Glahder J.A....Norrild B. (2003)
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
22. The POU domain factor Skin-1a represses the keratin 14 promoter independent of DNA binding. A possible role for interactions between Skn-1a and CREB-binding protein/p300. (PubMed id 11429405)¹ Sugihara T.M....Andersen B. (2001)
23. Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation. (PubMed id 9242494)¹ Andersen B....Rosenfeld M.G. (1997)
24. Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11. (PubMed id 8441607)¹ Goldsborough A.S....Ashworth A. (1993)
25. A 13-mer peptide straddling the leucine33/proline33 polymorphism in glycoprotein IIIa does not define the PLA1 epitope. (PubMed id 1708295)⁹ Flug F....Karpatkin S. (1991)
26. Characterization of Skn-1a/i POU domain factors and linkage to papillomavirus gene expression. (PubMed id 9188490)⁹ Andersen B....Rosenfeld M.G. (1997)
27. Plasma membrane-specific phospholipase A1 activation by nitrogen dioxide in pulmonary artery endothelial cells. (PubMed id 2000640)⁹ Sekharam K.M....Block E.R. (1991)
28. PLASTOCHRON1, a timekeeper of leaf initiation in rice, encodes cytochrome P450. (PubMed id 14711998)⁹ Miyoshi K....Kurata N. (2004)
29. No evidence that the PLA1/PLA2 polymorphism of platelet glycoprotein IIIa is implicated in angiographically characterized coronary atherosclerosis and premature myocardial infarction. (PubMed id 14614355)⁹ Lagercrantz J....Eriksson P. (2003)
30. Differential activity by DNA-induced quarternary structures of POU transcription factors. (PubMed id 12213595)⁹ Remenyi A....Wilmanns M. (2002)
31. A requirement for the POU transcription factor, Brn-2, in corticotropin-releasing hormone expression in a neuronal cell line. (PubMed id 10446900)⁹ Ramkumar T. and Adler S. (1999)
32. Examination of POU homeobox gene expression in human breast cancer cells. (PubMed id 10077160)⁹ Jin T....Goss P.E. (1999)
33. Correlation of MIB-1 antigen expression with transcription factors Skn-1, Oct-1, AP-2, and HPV type in cervical intraepithelial neoplasia. (PubMed id 9422986)⁹ Hietala K.A....Kellokoski J.K. (1997)
34. Identification of a chicken homologue in the Brn-3 subfamily of POU-transcription factors. (PubMed id 9205808)⁹ Lindeberg J....Ebendal T. (1997)
35. Differential regulation of genes encoding synaptic proteins by members of the Brn-3 subfamily of POU transcription factors. (PubMed id 9037543)⁹ Morris P.J....Latchman D.S. (1996)
36. POU transcription factors differentially regulate the D1A dopamine receptor gene in cultured cells. (PubMed id 8651914)⁹ Imafuku I....Okazawa H. (1996)
37. Regulation of human involucrin promoter activity by POU domain proteins. (PubMed id 8663077)⁹ Welter J.F....Eckert R.L. (1996)
38. Activation and repression of gene expression by POU family transcription factors. (PubMed id 8735273)⁹ Latchman D.S. (1996)
39. Increased phospholipase A activities in sera of intensive-care patients show sn-2 specificity but no acyl-chain selectivity. (PubMed id 8485868)⁹ Puttmann M....Hoffmann G.E. (1993)
40. EEL-1, a Hect E3 ubiquitin ligase, controls asymmetry and persistence of the SKN-1 transcription factor in the early C. elegans embryo. (PubMed id 17537795)⁹ Page B.D....Ferguson E.L. (2007)
41. Coronary artery bypass grafting using a bifurcating radial artery. (PubMed id 17670123)⁹ Sakaguchi H....Kawasuji M. (2003)
42. Biochemical and molecular characterization of two phosphatidic acid- selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta. (PubMed id 12963729)⁹ Hiramatsu T.... Arai H. (2003)
43. POU family transcription factors in the nervous system. (PubMed id 10199551)⁹ Latchman D.S. (1999)
44. Cardiolipin hydrolysis by human phospholipases A2. The multiple enzymatic activities of human cytosolic phospholipase A2. (PubMed id 9487141)⁹ Buckland A.G....Wilton D.C. (1998)
45. Local expression of a POU family transcription factor, Pit-1, in the rat placenta. (PubMed id 8735586)⁹ Lee B.J....Choi W.S. (1996)
46. The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements. (PubMed id 8670054)⁹ Dawson S.J....Latchman D.S. (1996)
47. Activation of the herpes simplex virus immediate-early gene promoters by neuronally expressed POU family transcription factors. (PubMed id 7733899)⁹ Lillycrop K.A....Latchman D.S. (1995)
48. POU family transcription factors in sensory neurons. (PubMed id 1426602)⁹ Latchman D.S....Wood J.N. (1992)
49. Synthesis of lysophospholipids. (PubMed id 20335986)⁹ D'Arrigo P. and Servi S. (2010)
50. [OCT4 expression in hepatocellular carcinoma and its clinical significance] (PubMed id 20038322)⁹ Huang P.Z....Yuan Y.F. (2010)
51. PLASTOCHRON3/GOLIATH encodes a glutamate carboxypepti dase required for proper development in rice. (PubMed id 19228340)⁹ Kawakatsu T....Nagato Y. (2009)
52. The tumor suppressor gene H-Rev107 functions as a novel Ca2+-independent cytosolic phospholipase A1/2 of the thiol hydrolase type. (PubMed id 19047760)⁹ Uyama T....Ueda N. (2009)
53. Simultaneous preparation of purified plasmalogens and sphingomyelin in human erythrocytes with phospholipase A1 from Aspergillus ori zae. (PubMed id 19966491)⁹ Mawatari S....Fujino T. (2009)
54. Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development. (PubMed id 19147497)⁹ Jin Z....Jing N. (2009)
55. The hemolytic and cytolytic activities of Serratia ma rcescens phospholipase A (PhlA) depend on lysophospholipid production by PhlA. (PubMed id 20003541)⁹ Shimuta K....Watanabe H. (2009)
56. POU domain transcription factors: BRN2 as a regulator of melanocytic growth and tumourigenesis. (PubMed id 18983536)⁹ Cook A.L. and Sturm R.A. (2008)
57. The POU homeobox protein Oct-1 regulates radial glia formation downstream of Notch signaling. (PubMed id 18241856)⁹ Kiyota T....Kato Y. (2008)
58. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. (PubMed id 18358814)⁹ Tullet J.M....Blackwell T.K. (2008)
59. Characterization of an Oct1 orthologue in the channel catfish, Ictalurus punctatus: a negative regulator of immunoglobulin gene transcription? (PubMed id 17266766)⁹ Lennard M.L....Warr G.W. (2007)
60. Crystallization of hepatocyte nuclear factor 1beta in complex with DNA. (PubMed id 16754972)⁹ Lu P....Chi Y.I. (2006)
61. Transcriptional regulation of renin: an update. (PubMed id 15545507)⁹ Pan L. and Gross K.W. (2005)
62. Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis. (PubMed id 15513931)⁹ Tai M.H....Trosko J.E. (2005)
63. Isolation and characterization of the human Cdc2L1 gene promoter. (PubMed id 15656972)⁹ Kahle A....A Nelson M. (2005)
64. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. (PubMed id 16325584)⁹ Niwa H....Rossant J. (2005)
65. Oct-3/4 maintains the proliferative embryonic stem cell state via specific binding to a variant octamer sequence in the regulatory region of the UTF1 locus. (PubMed id 15923625)⁹ Nishimoto M....Okuda A. (2005)
66. Determination of transcription factors and their possible roles in the regulation of Pax3 gene expression in the mouse B16 F1 melanoma cell line. (PubMed id 16179863)⁹ Zhu B.K. and Pruitt S.C. (2005)
67. Identification of PIK3C3 promoter variant associated with bipolar disorder and schizophrenia. (PubMed id 15121481)⁹ Stopkova P....Lachman H.M. (2004)
68. Mechanisms of lysophosphatidic acid production. (PubMed id 15271293)⁹ Aoki J. (2004)
69. Increased prevalence of platelet glycoprotein IIb/IIIa PLA2 allele in ischaemic stroke associated with large vessel pathology. (PubMed id 12818249)⁹ Szolnoki Z....Melegh B. (2003)
70. Displacement of YY1 by differentiation-specific transcription factor hSkn-1a activates the P(670) promoter of human papillomavirus type 16. (PubMed id 11533193)⁹ Kukimoto I. and Kanda T. (2001)
71. The hSkn-1a POU transcription factor enhances epiderm al stratification by promoting keratinocyte proliferation. (PubMed id 11329378)⁹ Hildesheim J....Vogel J.C. (2001)
72. A point mutation in the LIM domain of Lhx3 reduces activation of the glycoprotein hormone alpha-subunit promoter. (PubMed id 11279219)⁹ Howard P.W. and Maurer R.A. (2001)
73. Restriction of mesendoderm to a single blastomere by the combined action of SKN-1 and a GSK-3beta homolog is mediated by MED-1 and - 2 in C. elegans. (PubMed id 11463373)⁹ Maduro M.F....Rothman J.H. (2001)
74. Initial fetal platelet counts predict the response to intravenous gammaglobulin therapy in fetuses that are affected by PLA1 incompatibility. (PubMed id 11641688)⁹ Gaddipati S....Bussel J.B. (2001)
75. Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4. (PubMed id 11689681)⁹ Ezashi T....Roberts R.M. (2001)
76. Identification of the transactivation domain of the transcription factor Sox-2 and an associated co-activator. (PubMed id 10660531)⁹ Nowling T.K....Rizzino A. (2000)
77. A novel phosphatidylglycerol-selective phospholipase A2 from macrophages. (PubMed id 10026244)⁹ Shinozaki K. and Waite M. (1999)
78. Molecular characterization of cytosolic phospholipase A2-beta. (PubMed id 10358058)⁹ Song C.... Kriz R.W. (1999)
79. Coronary thrombosis and the platelet glycoprotein IIIA gene PLA2 polymorphism. (PubMed id 9716140)⁹ Durante-Mangoni E....Tuddenham E.G. (1998)
80. Platelet glycoprotein IIb/IIIa genetic polymorphism is associated with plasma fibrinogen levels in myocardial infarction patients. The REGICOR Investigators. (PubMed id 9876897)⁹ Senti M....Marrugat J. (1998)
81. Regulation of POU genes by castor and hunchback establishes layered compartments in the Drosophila CNS. (PubMed id 9436984)⁹ Kambadur R....Odenwald W.F. (1998)
82. High expression of the POU factor Brn3a in aggressive neuroendocrine tumors. (PubMed id 8989239)⁹ Leblond-Francillard M....de Keyzer Y. (1997)
83. A pancreatic lipase with a phospholipase A1 activity: crystal structure of a chimeric pancreatic lipase-related protein 2 from guinea pig. (PubMed id 8939760)⁹ Withers-Martinez C....Cambillau C. (1996)
84. Interdependent transcription control elements regulate the expression of the SPRR2A gene during keratinocyte terminal differentiation. (PubMed id 8816448)⁹ Fischer D.F....Backendorf C. (1996)
85. Differential effects of phorbol 12-myristate 13-acetate and diacylglycerols on thromboxane A2-independent phospholipase A2 activation in collage-stimulated human platelets. (PubMed id 8043296)⁹ Reddy S....Murthy M. (1994)
86. Prediction of neonatal alloimmune thrombocytopenia us ing PCR. (PubMed id 8165025)⁹ Marshall L.R....Munro T.E. (1994)
87. A CNS-specific POU transcription factor, Brn-2, is re quired for establishing mammalian neural cell lineages. (PubMed id 8274283)⁹ Fujii H. and Hamada H. (1993)
88. A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells. (PubMed id 1383937)⁹ Lillycrop K.A....Latchman D.S. (1992)
89. Competitive binding of a monoclonal antibody SZ-21 wi th anti-PLA1 antibodies and its potential for clinical application. (PubMed id 1383923)⁹ Xi X....Ruan C. (1992)
90. Antigen expression of frozen platelets. (PubMed id 1633681)⁹ Chow M.P....Lee T.D. (1992)

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