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Aliases for POU2F3 Gene

Aliases for POU2F3 Gene

  • POU Class 2 Homeobox 3 2 3 5
  • Octamer-Binding Transcription Factor 11 3 4
  • Octamer-Binding Protein 11 3 4
  • Transcription Factor PLA-1 3 4
  • Transcription Factor Skn-1 3 4
  • OCT-11 3 4
  • OTF-11 3 4
  • PLA1 3 4
  • POU Domain, Class 2, Transcription Factor 3 3
  • POU Domain Class 2, Transcription Factor 3 2
  • POU Domain Transcription Factor OCT11a 3
  • Epoc-1 3
  • Skn-1a 3
  • OCT11 3
  • PLA-1 3
  • OTF11 4

External Ids for POU2F3 Gene

Previous GeneCards Identifiers for POU2F3 Gene

  • GC11P122110
  • GC11P121622
  • GC11P120144
  • GC11P119648
  • GC11P119616
  • GC11P116050

Summaries for POU2F3 Gene

Entrez Gene Summary for POU2F3 Gene

  • This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for POU2F3 Gene

POU2F3 (POU Class 2 Homeobox 3) is a Protein Coding gene. Diseases associated with POU2F3 include Blood Coagulation Disease and Hemorrhagic Disease. Among its related pathways are Influenza A. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is POU2F1.

UniProtKB/Swiss-Prot for POU2F3 Gene

  • Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.

Gene Wiki entry for POU2F3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU2F3 Gene

Genomics for POU2F3 Gene

Regulatory Elements for POU2F3 Gene

Enhancers for POU2F3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G120207 1.7 FANTOM5 ENCODE dbSUPER 29.1 -25.5 -25472 6.9 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 FOS SP3 SP5 POU2F3 TRIM29 LOC729173 OAF ARHGEF12 GRIK4
GH11G120217 1 ENCODE dbSUPER 30.8 -16.7 -16720 4.8 ELF3 SOX13 DRAP1 SAP130 ARID4B RAD21 ZIC2 RARA YY1 ZNF664 POU2F3 TRIM29 LOC729173 TMEM136 OAF
GH11G120316 1.4 Ensembl ENCODE dbSUPER 16.5 +80.5 80505 1.9 NFIB SIN3A DMAP1 THRB RARA ZNF335 EGR1 FOS RELB IKZF2 POU2F3 TMEM136 GC11P120299
GH11G120181 1.5 Ensembl ENCODE dbSUPER 12.1 -50.3 -50297 9.0 HDGF ZFP64 WRNIP1 ARID4B DMAP1 ZNF48 YY1 ZNF143 FOS ZNF263 OAF POU2F3 TRIM29 LOC729173 LOC105369530
GH11G120280 0.9 ENCODE 16.9 +44.5 44455 2.1 HDAC1 PKNOX1 CBX3 RB1 TBL1XR1 ARNT TCF12 GATA2 SMARCA5 ZBTB2 POU2F3 TMEM136 TRIM29 ARHGEF12 LOC105369520 GC11P120275 LOC105369531
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POU2F3 on UCSC Golden Path with GeneCards custom track

Genomic Location for POU2F3 Gene

Chromosome:
11
Start:
120,236,640 bp from pter
End:
120,319,945 bp from pter
Size:
83,306 bases
Orientation:
Plus strand

Genomic View for POU2F3 Gene

Genes around POU2F3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POU2F3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POU2F3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU2F3 Gene

Proteins for POU2F3 Gene

  • Protein details for POU2F3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKI9-PO2F3_HUMAN
    Recommended name:
    POU domain, class 2, transcription factor 3
    Protein Accession:
    Q9UKI9
    Secondary Accessions:
    • A8K7H8
    • B4DY07
    • F5GWW6
    • Q3MIY3
    • Q9UKR7
    • Q9Y504

    Protein attributes for POU2F3 Gene

    Size:
    436 amino acids
    Molecular mass:
    47432 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for POU2F3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POU2F3 Gene

Post-translational modifications for POU2F3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for POU2F3

No data available for DME Specific Peptides for POU2F3 Gene

Domains & Families for POU2F3 Gene

Gene Families for POU2F3 Gene

Suggested Antigen Peptide Sequences for POU2F3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKI9

UniProtKB/Swiss-Prot:

PO2F3_HUMAN :
  • Belongs to the POU transcription factor family. Class-2 subfamily.
Family:
  • Belongs to the POU transcription factor family. Class-2 subfamily.
genes like me logo Genes that share domains with POU2F3: view

Function for POU2F3 Gene

Molecular function for POU2F3 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.

Gene Ontology (GO) - Molecular Function for POU2F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IMP 12624109
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IMP 12624109
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 12624109
genes like me logo Genes that share ontologies with POU2F3: view
genes like me logo Genes that share phenotypes with POU2F3: view

Animal Models for POU2F3 Gene

MGI Knock Outs for POU2F3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POU2F3 Gene

Localization for POU2F3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU2F3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POU2F3 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for POU2F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 9242494
genes like me logo Genes that share ontologies with POU2F3: view

Pathways & Interactions for POU2F3 Gene

SuperPathways for POU2F3 Gene

SuperPathway Contained pathways
1 Influenza A
genes like me logo Genes that share pathways with POU2F3: view

Pathways by source for POU2F3 Gene

1 KEGG pathway for POU2F3 Gene

Gene Ontology (GO) - Biological Process for POU2F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10473598
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0008544 epidermis development TAS 10473598
genes like me logo Genes that share ontologies with POU2F3: view

No data available for SIGNOR curated interactions for POU2F3 Gene

Drugs & Compounds for POU2F3 Gene

(2) Drugs for POU2F3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for POU2F3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with POU2F3: view

Transcripts for POU2F3 Gene

Unigene Clusters for POU2F3 Gene

POU class 2 homeobox 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POU2F3 Gene

No ASD Table

Relevant External Links for POU2F3 Gene

GeneLoc Exon Structure for
POU2F3
ECgene alternative splicing isoforms for
POU2F3

Expression for POU2F3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POU2F3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for POU2F3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x21.9) and Skin - Not Sun Exposed (Suprapubic) (x21.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POU2F3 Gene



NURSA nuclear receptor signaling pathways regulating expression of POU2F3 Gene:

POU2F3

SOURCE GeneReport for Unigene cluster for POU2F3 Gene:

Hs.227115

mRNA Expression by UniProt/SwissProt for POU2F3 Gene:

Q9UKI9-PO2F3_HUMAN
Tissue specificity: Specifically expressed in epidermis and cultured keratinocytes.

Evidence on tissue expression from TISSUES for POU2F3 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
  • Blood(2.7)
  • Skin(2.5)
genes like me logo Genes that share expression patterns with POU2F3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for POU2F3 Gene

Orthologs for POU2F3 Gene

This gene was present in the common ancestor of animals.

Orthologs for POU2F3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POU2F3 34 35
  • 92.51 (n)
dog
(Canis familiaris)
Mammalia POU2F3 34 35
  • 91.45 (n)
cow
(Bos Taurus)
Mammalia POU2F3 34 35
  • 90.98 (n)
mouse
(Mus musculus)
Mammalia Pou2f3 34 16 35
  • 90.05 (n)
rat
(Rattus norvegicus)
Mammalia Pou2f3 34
  • 89.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia POU2F3 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POU2F3 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves POU2F3 34 35
  • 77.51 (n)
lizard
(Anolis carolinensis)
Reptilia POU2F3 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pou2f3 34
  • 69.59 (n)
zebrafish
(Danio rerio)
Actinopterygii pou2f3 34 35
  • 66.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta pdm2 35
  • 18 (a)
ManyToMany
nub 35
  • 17 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-18 35
  • 22 (a)
OneToMany
Species where no ortholog for POU2F3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POU2F3 Gene

ENSEMBL:
Gene Tree for POU2F3 (if available)
TreeFam:
Gene Tree for POU2F3 (if available)

Paralogs for POU2F3 Gene

(13) SIMAP similar genes for POU2F3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with POU2F3: view

Variants for POU2F3 Gene

Sequence variations from dbSNP and Humsavar for POU2F3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000008682 -- 120,276,517(+) AGGAT(C/G)CAGCC intron-variant
rs1000022772 -- 120,304,525(+) AGTTC(C/T)ATGAA intron-variant
rs1000042506 -- 120,318,708(+) TTTCA(C/G)AGAAA utr-variant-3-prime
rs1000075814 -- 120,254,284(+) AGTCT(C/G)TCCCA intron-variant
rs1000109236 -- 120,291,601(+) AGTGA(A/G)GATTG intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for POU2F3 Gene

Variant ID Type Subtype PubMed ID
esv2550380 CNV insertion 19546169
esv2612935 CNV insertion 19546169
esv3379673 CNV duplication 20981092
nsv518 CNV insertion 18451855
nsv518464 CNV loss 19592680
nsv522706 CNV loss 19592680

Variation tolerance for POU2F3 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.40; 85.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POU2F3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POU2F3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU2F3 Gene

Disorders for POU2F3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for POU2F3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
blood coagulation disease
  • postpartum coagulation defect
hemorrhagic disease
  • hemorrhagic diathesis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POU2F3

Genetic Association Database (GAD)
POU2F3
Human Genome Epidemiology (HuGE) Navigator
POU2F3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POU2F3
genes like me logo Genes that share disorders with POU2F3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POU2F3 Gene

Publications for POU2F3 Gene

  1. Characterization of the regulatory domains of the human skn-1a/Epoc- 1/Oct-11 POU transcription factor. (PMID: 10473598) Hildesheim J. … Vogel J.C. (J. Biol. Chem. 1999) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation. (PMID: 17195013) Beck I.M. … Sedlacek R. (J. Invest. Dermatol. 2007) 3 22 64
  4. The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression. (PMID: 16005513) JimAcnez-Mateo O. … Castrillo J.L. (Placenta 2006) 3 22 64
  5. Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer. (PMID: 16607278) Zhang Z. … Rader J.S. (Oncogene 2006) 3 22 64

Products for POU2F3 Gene

Sources for POU2F3 Gene

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