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Aliases for POU2F3 Gene

Aliases for POU2F3 Gene

  • POU Class 2 Homeobox 3 2 3
  • Octamer-Binding Transcription Factor 11 3 4
  • Octamer-Binding Protein 11 3 4
  • Transcription Factor PLA-1 3 4
  • Transcription Factor Skn-1 3 4
  • OCT-11 3 4
  • OTF-11 3 4
  • OCT11 3 6
  • PLA1 3 4
  • POU Domain, Class 2, Transcription Factor 3 3
  • POU Domain Class 2, Transcription Factor 3 2
  • POU Domain Transcription Factor OCT11a 3
  • Epoc-1 3
  • Skn-1a 3
  • PLA-1 3
  • OTF11 4

External Ids for POU2F3 Gene

Previous GeneCards Identifiers for POU2F3 Gene

  • GC11P122110
  • GC11P121622
  • GC11P120144
  • GC11P119648
  • GC11P119616
  • GC11P116050

Summaries for POU2F3 Gene

Entrez Gene Summary for POU2F3 Gene

  • This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for POU2F3 Gene

POU2F3 (POU Class 2 Homeobox 3) is a Protein Coding gene. Diseases associated with POU2F3 include coronary thrombosis. Among its related pathways are Influenza A. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is POU6F1.

UniProtKB/Swiss-Prot for POU2F3 Gene

  • Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Regulated the expression of a number of genes such as SPRR2A or placental lactogen

Gene Wiki entry for POU2F3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU2F3 Gene

Genomics for POU2F3 Gene

Regulatory Elements for POU2F3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POU2F3 Gene

Start:
120,236,640 bp from pter
End:
120,319,944 bp from pter
Size:
83,305 bases
Orientation:
Plus strand

Genomic View for POU2F3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POU2F3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU2F3 Gene

Proteins for POU2F3 Gene

  • Protein details for POU2F3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKI9-PO2F3_HUMAN
    Recommended name:
    POU domain, class 2, transcription factor 3
    Protein Accession:
    Q9UKI9
    Secondary Accessions:
    • A8K7H8
    • B4DY07
    • F5GWW6
    • Q3MIY3
    • Q9UKR7
    • Q9Y504

    Protein attributes for POU2F3 Gene

    Size:
    436 amino acids
    Molecular mass:
    47432 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for POU2F3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POU2F3 Gene

Proteomics data for POU2F3 Gene at MOPED

Post-translational modifications for POU2F3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU2F3 Gene

No data available for DME Specific Peptides for POU2F3 Gene

Domains for POU2F3 Gene

Gene Families for POU2F3 Gene

HGNC:
  • POU :Homeoboxes / POU class

Suggested Antigen Peptide Sequences for POU2F3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKI9

UniProtKB/Swiss-Prot:

PO2F3_HUMAN :
  • Q9UKI9
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 POU-specific domain.
Family:
  • Belongs to the POU transcription factor family. Class-2 subfamily.
genes like me logo Genes that share domains with POU2F3: view

Function for POU2F3 Gene

Molecular function for POU2F3 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Regulated the expression of a number of genes such as SPRR2A or placental lactogen

Gene Ontology (GO) - Molecular Function for POU2F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IMP 12624109
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP 12624109
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding IPI 12624109
genes like me logo Genes that share ontologies with POU2F3: view
genes like me logo Genes that share phenotypes with POU2F3: view

Animal Models for POU2F3 Gene

MGI Knock Outs for POU2F3:

Animal Model Products

miRNA for POU2F3 Gene

miRTarBase miRNAs that target POU2F3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POU2F3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for POU2F3 Gene

Localization for POU2F3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU2F3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POU2F3 Gene COMPARTMENTS Subcellular localization image for POU2F3 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for POU2F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9242494
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with POU2F3: view

Pathways for POU2F3 Gene

SuperPathways for POU2F3 Gene

Superpath Contained pathways
1 Influenza A
genes like me logo Genes that share pathways with POU2F3: view

Pathways by source for POU2F3 Gene

1 KEGG pathway for POU2F3 Gene

Gene Ontology (GO) - Biological Process for POU2F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10473598
GO:0008544 epidermis development TAS 10473598
GO:0030216 keratinocyte differentiation IEA --
genes like me logo Genes that share ontologies with POU2F3: view

Compounds for POU2F3 Gene

(4) Novoseek inferred chemical compound relationships for POU2F3 Gene

Compound -log(P) Hits PubMed IDs
phospholipid 26.9 3
retinoic acid 2.16 1
zinc 0 1
heparin 0 2
genes like me logo Genes that share compounds with POU2F3: view

Transcripts for POU2F3 Gene

Unigene Clusters for POU2F3 Gene

POU class 2 homeobox 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POU2F3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POU2F3 Gene

No ASD Table

Relevant External Links for POU2F3 Gene

GeneLoc Exon Structure for
POU2F3
ECgene alternative splicing isoforms for
POU2F3

Expression for POU2F3 Gene

mRNA expression in normal human tissues for POU2F3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for POU2F3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (21.9) and Skin - Not Sun Exposed (Suprapubic) (21.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POU2F3 Gene

SOURCE GeneReport for Unigene cluster for POU2F3 Gene Hs.227115

mRNA Expression by UniProt/SwissProt for POU2F3 Gene

Q9UKI9-PO2F3_HUMAN
Tissue specificity: Specifically expressed in epidermis and cultured keratinocytes
genes like me logo Genes that share expressions with POU2F3: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Expression partners for POU2F3 Gene

Orthologs for POU2F3 Gene

This gene was present in the common ancestor of animals.

Orthologs for POU2F3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POU2F3 35
  • 90.98 (n)
  • 94.04 (a)
POU2F3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POU2F3 35
  • 91.45 (n)
  • 93.45 (a)
POU2F3 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pou2f3 35
  • 90.05 (n)
  • 93.01 (a)
Pou2f3 16
Pou2f3 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POU2F3 35
  • 92.51 (n)
  • 90.37 (a)
POU2F3 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pou2f3 35
  • 89.12 (n)
  • 92.31 (a)
oppossum
(Monodelphis domestica)
Mammalia POU2F3 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POU2F3 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves POU2F3 35
  • 77.51 (n)
  • 80.05 (a)
POU2F3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POU2F3 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pou2f3 35
  • 69.59 (n)
  • 72.26 (a)
zebrafish
(Danio rerio)
Actinopterygii pou2f3 35
  • 66.5 (n)
  • 66.92 (a)
pou2f3 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nub 36
  • 17 (a)
ManyToMany
pdm2 36
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-18 36
  • 22 (a)
OneToMany
Species with no ortholog for POU2F3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POU2F3 Gene

ENSEMBL:
Gene Tree for POU2F3 (if available)
TreeFam:
Gene Tree for POU2F3 (if available)

Paralogs for POU2F3 Gene

Selected SIMAP similar genes for POU2F3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with POU2F3: view

Variants for POU2F3 Gene

Sequence variations from dbSNP and Humsavar for POU2F3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs717051 -- 120,309,948(-) TTCTC(A/G)TTCTG intron-variant
rs717052 -- 120,309,770(-) CTCTA(C/T)TGAAA intron-variant
rs744983 -- 120,295,649(-) TTCCA(C/T)ATCCT intron-variant
rs744984 -- 120,295,701(-) TGGCA(C/T)CTCTA intron-variant
rs753309 -- 120,268,176(-) GACTT(C/T)TATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POU2F3 Gene

Variant ID Type Subtype PubMed ID
esv2612935 CNV Insertion 19546169
esv2550380 CNV Insertion 19546169
nsv522706 CNV Loss 19592680

Relevant External Links for POU2F3 Gene

HapMap Linkage Disequilibrium report
POU2F3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU2F3 Gene

Disorders for POU2F3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for POU2F3 Gene in MalaCards »

(1) Diseases for POU2F3 Gene including...

(2) University of Copenhagen DISEASES for POU2F3 Gene

(4) Novoseek inferred disease relationships for POU2F3 Gene

Disease -log(P) Hits PubMed IDs
choriocarcinoma 32 1
herpes simplex 2.12 1
thrombocytopenia 0 1
tumors 0 4

Relevant External Links for POU2F3

Genetic Association Database (GAD)
POU2F3
Human Genome Epidemiology (HuGE) Navigator
POU2F3
genes like me logo Genes that share disorders with POU2F3: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for POU2F3 Gene

Publications for POU2F3 Gene

  1. Characterization of the regulatory domains of the human skn-1a/Epoc- 1/Oct-11 POU transcription factor. (PMID: 10473598) Hildesheim J. … Vogel J.C. (J. Biol. Chem. 1999) 2 3 4
  2. The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression. (PMID: 16005513) JimAcnez-Mateo O. … Castrillo J.L. (Placenta 2006) 3 23
  3. Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer. (PMID: 16607278) Zhang Z. … Rader J.S. (Oncogene 2006) 3 23
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation. (PMID: 17195013) Beck I.M. … Sedlacek R. (J. Invest. Dermatol. 2007) 3 23

Products for POU2F3 Gene

Sources for POU2F3 Gene

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