POU2F2 Gene
protein-coding GIFtS : 60 GCID: GC19 M042592
POU class 2 homeobox 2 POU domain class 2, transcription factor 2 )OTF2 )
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Aliasesfor POU2F2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases POU Class 2 Homeobox 2 1 2 OTF-22 3 OCT21 2 3 5 Oct-22 3 OTF21 2 3 5 POU Domain Class 2, Transcription Factor 21 Lymphoid-Restricted Immunoglobulin Octamer-Binding Protein NF-A22 3 Homeobox Protein2 Octamer-Binding Protein 22 3 POU Domain, Class 2, Transcription Factor 22 Octamer-Binding Transcription Factor 22 3
Export aliases for POU2F2 gene to outside databases Previous GC identifers: GC19M043234 GC19M042986 GC19M047271 GC19M047286 GC19M039023
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Summariesfor POU2F2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for POU2F2 : The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011) UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086 Function : Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcriptionin a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter
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Genomic Viewsfor POU2F2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_011109.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the POU2F2 gene promoter:NRSF form 1 NRSF form 2 Evi-1 E47 HNF-4alpha1 PPAR-gamma1 PPAR-gamma2 Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for POU2F2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2 POU2F2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19M042592: view genomic region
(about GC identifiers )
Start: 42,592,650 bp from pter End:
42,700,737 bp from pter
Size: 108,088 bases Orientation:
minus strand
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Proteinsfor POU2F2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086 See
protein sequence )Recommended Name: Size : 479 amino acids; 51209 DaSubunit : Interacts with NR3C1, AR and PGRSubcellular location : Cytoplasm (By similarity). NucleusSequence caution : Sequence=CAA32039.1; Type=Erroneous initiation;1 PDB 3D structure from :1HDP (3D) Secondary accessions : Q16648 Q7M4M8 Q9BRS4Alternative splicing : 5 isoforms : P09086-1 P09086-2 P09086-3 P09086-4 P09086-5 (Incomplete sequence)Explore the universe of human proteins at neXtProt for POU2F2: NX_P09086 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P09086 POU2F2 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (4 alternative transcripts): NP_001193954.1 NP_001193955.1 NP_001234923.1 NP_002689.1 ENSEMBL proteins: ENSP00000373992 ENSP00000437221 ENSP00000452930 ENSP00000431603 ENSP00000437224 ENSP00000436100 ENSP00000453995 ENSP00000454179 ENSP00000453255 ENSP00000436988 ENSP00000454056 ENSP00000431679 ENSP00000453164 ENSP00000453794 ENSP00000339369 ENSP00000292077 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing POU2F2 Antibody Products: Assay Products for POU2F2:
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Protein
Domains /for POU2F2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry P09086 ProtoNet protein and cluster: P09086
3 Blocks protein families : IPB000327 IPB000972 IPB013847 UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086 Similarity : Belongs to the POU transcription factor family. Class-2 subfamilySimilarity : Contains 1 homeobox DNA-binding domainSimilarity : Contains 1 POU-specific domain
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Functionfor POU2F2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086 Function : Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcriptionin a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter
Genatlas biochemistry entry for POU2F2 POU domain,class 2,transcription factor 2,expressed in the immune system,also involved in the control of the forebrain development and the cell-cell signaling process underlying the hypothalamic regulation of female puberty Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: POU2F2 (NM_002698 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POU2F2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat POU2F2
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F2
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding
-- -- GO:0003700 sequence-specific DNA binding transcription factor activity
IEA -- GO:0019904 protein domain specific binding
IEA -- GO:0043565 sequence-specific DNA binding
IDA 9242494
About GeneDecksing 1 GenomeRNAi human phenotype for POU2F2 :Animal Models: Pou2f2 tm1Bal Pou2f2 tm1Lmc 8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pou2f2) :About GeneDecksing
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Pathways & Interactionsfor POU2F2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) 2 SIDS Susceptibility Pathways 3 B cell receptor signaling pathway
Pathway sources See GeneCards unified pathways Show all pathways 1 1 2 About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU2F2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)5/17 Interacting proteins for POU2F2 (P09086 3 ENSP00000373992 4 via UniProtKB, MINT, STRING , and/or I2D (see all 17 )About this table Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0002335 mature B cell differentiation
IEA -- GO:0002380 immunoglobulin secretion involved in immune response
IEA -- GO:0006351 transcription, DNA-dependent
-- -- GO:0006355 regulation of transcription, DNA-dependent
-- -- GO:0006366 transcription from RNA polymerase II promoter
TAS 9442393
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Drugs & Compoundsfor POU2F2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for POU2F2 7 Novoseek chemical compound relationships for POU2F2 gene About this table POU2F2 / PO2F2
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Transcriptsfor POU2F2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for POU2F2 gene (4 alternative transcripts): NM_001207025.2 NM_001207026.1 NM_001247994.1 NM_002698.4 Unigene Cluster for POU2F2:
POU class 2 homeobox 2 Hs.147381 [show with all ESTs ] Unigene Representative Sequence: NM_001207025 18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20 ): ENST00000389341 (uc002osn.3 uc002osq.3 ) ENST00000533720 ENST00000560804 ENST00000526816 ENST00000529067 ENST00000534559 ENST00000533548 ENST00000560558 ENST00000560398 ENST00000529952 (uc002osr.2 ) ENST00000528894 ENST00000526831 ENST00000530982 ENST00000531773 ENST00000524801 ENST00000532176 ENST00000526933 ENST00000558596 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: POU2F2 (NM_002698 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POU2F2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat POU2F2
Additional cDNA sequence: AL833648.1 BC006101.1 BT007438.1 M22596.1 M36542.1 M36653.1 M36718.1 M36772.1 X13809.1 X13810.1 X53468.1 X53469.1
16 DOTS entries : DT.100785009 DT.99990511
DT.95069801 DT.100785010 DT.121453175 DT.91700060 DT.413141 DT.100785013 DT.413142 DT.413561 DT.65286027 DT.86836027 DT.91741185 DT.95069804 DT.97762188 DT.97775242 24/219 AceView cDNA sequences (see all 219 ):
AA832036 AA417604 CR604513 AW316809 BM810914 AA731643 CR615602 AW135115 BE675200 AA894446 AU186044 AA011627 AA829950 M36718 CF137658 CA307156 AI364649 BU430118 AA805083 AW166309 AI553728 AI300318 AI208828 AA884256 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for POU2F2 (see all 7 ) About this scheme ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ SP1 : - - - - - - - - SP2 : - - - - - SP3 : - - - SP4 : - - - - SP5 : - - -
ExUns: 19 SP1 : SP2 : SP3 : SP4 : SP5 :
ECgene alternative splicing isoforms for POU2F2
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Expression for POU2F2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section POU2F2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTGGAGATGA
About this image POU2F2 expression in embryonic tissues and stem cells About this table 3 LifeMap In Vivo Development Anatomical Compartments/CellsTissue Category (developmental path) Brain Hypothalamus Brain Brain Thalamus Brain Neural Tube Diencephalon Neural Tube Expression: Experimental details:
In-situ hybridization
See POU2F2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for POU2F2 SOURCE GeneReport for Unigene cluster: Hs.147381 UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086 Tissue specificity : Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressingT-cell line MOLT-4, but not in the T-cell line BW5147 SABiosciences Expression via Pathway-Focused PCR Arrays including POU2F2 : T Helper Cell Differentiation in human mouse rat Homeobox (HOX) Genes in human mouse rat
Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F2
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Orthologsfor POU2F2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for POU2F2 gene from 4/12 species (see all 12 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
lizard Reptilia POU2F26
--
42(a)
1 ↔ 1
GL343909.1(96375-106147)
zebrafish Actinopterygii LOC1005349341
POU domain, class 2, transcription factor 2-like
66.98(n) 70.26(a)
100534934 XM_003200146.1 XP_003200194.1
fruit fly Insecta nub3
neuroblast determination transcription
74(a)
--
worm Secernentea ceh-63
Homeobox domain, Pou domain - N-terminal tomore
55(a)
I(8506480-8510320) --
ENSEMBL Gene Tree for POU2F2 (if available)TreeFam Gene Tree for POU2F2 (if available)
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Paralogsfor POU2F2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for POU2F2 gene POU5F2 2 POU6F2 2 POU4F2 2 POU2F3 2 POU3F4 2 POU3F1 2 POU1F1 2 POU4F3 2 POU3F3 2 POU3F2 2 POU5F1B 2 POU2F1 2 POU4F1 2 POU5F1 2 POU6F1 2 14 SIMAP similar genes for POU2F2 using alignment to 13 protein entries: PO2F2_HUMAN (see all proteins ):OCT-2 OCT6 POU2F3 POU2F1 POU1F1 POU6F1 POU3F1 POU5F1P4 POU5F1P1 POU5F1B POU4F3 POU3F2 POU3F4 POU5F1 About GeneDecksing
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Genomic Variantsfor POU2F2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 19 pos Sequence # AA Type More # Allele Pop Total More
and Proteopedia 
for POU2F2:
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
Microarrays