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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU2F2 Gene

protein-coding   GIFtS: 60
GCID: GC19M042592

POU Class 2 Homeobox 2

(Previous names: POU domain class 2, transcription factor 2)
(Previous symbol: OTF2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
POU Class 2 Homeobox 21 2     OTF-22 3
OTF21 2 3 5     Oct-22 3
OCT22 3 5     POU Domain Class 2, Transcription Factor 21
Lymphoid-Restricted Immunoglobulin Octamer-Binding Protein NF-A22 3     Homeobox Protein2
Octamer-Binding Protein 22 3     POU Domain, Class 2, Transcription Factor 22
Octamer-Binding Transcription Factor 22 3     

External Ids:    HGNC: 92131   Entrez Gene: 54522   Ensembl: ENSG000000282777   OMIM: 1641765   UniProtKB: P090863   

Export aliases for POU2F2 gene to outside databases

Previous GC identifers: GC19M043234 GC19M042986 GC19M047271 GC19M047286 GC19M039023


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POU2F2 Gene:
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The
encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in
immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for POU2F2 Gene: 
POU2F2 (POU class 2 homeobox 2) is a protein-coding gene. Diseases associated with POU2F2 include breast lymphoma, and primary effusion lymphoma, and among its related super-pathways are Development Glucocorticoid receptor signaling and B cell receptor signaling pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein domain specific binding. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086
Function: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates
transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates
transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU2F2 gene promoter:
         NRSF form 1   NRSF form 2   Evi-1   E47   HNF-4alpha1   PPAR-gamma1   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOU2F2 promoter sequence
   Search SABiosciences Chromatin IP Primers for POU2F2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU2F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

POU2F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU2F2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M042592:  view genomic region     (about GC identifiers)

Start:
42,590,263 bp from pter      End:
42,700,737 bp from pter
Size:
110,475 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086 (See protein sequence)
Recommended Name: POU domain, class 2, transcription factor 2  
Size: 479 amino acids; 51209 Da
Subunit: Interacts with NR3C1, AR and PGR
Subcellular location: Cytoplasm (By similarity). Nucleus
Sequence caution: Sequence=CAA32039.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for POU2F2:
1HDP (3D)    
Secondary accessions: Q16648 Q7M4M8 Q9BRS4
Alternative splicing: 5 isoforms:  P09086-1   P09086-2   P09086-3   P09086-4   P09086-5   (Incomplete sequence)

Explore the universe of human proteins at neXtProt for POU2F2: NX_P09086

Explore proteomics data for POU2F2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P09086

  • POU2F2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    POU2F2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001193954.1  NP_001193955.1  NP_001234923.1  NP_002689.1  

    ENSEMBL proteins: 
     ENSP00000373992   ENSP00000437221   ENSP00000452930   ENSP00000431603   ENSP00000437224  
     ENSP00000436100   ENSP00000453995   ENSP00000454179   ENSP00000453255   ENSP00000436988  
     ENSP00000471890   ENSP00000475664   ENSP00000476062   ENSP00000476240   ENSP00000339369  

    Human Recombinant Protein Products for POU2F2: 
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    Novus Biologicals POU2F2 Protein
    Novus Biologicals POU2F2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9242494
    GO:0005737cytoplasm IEA--

    POU2F2 for ontologies           About GeneDecksing



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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    POU: Homeoboxes / POU class

    5/7 InterPro protein domains (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR000972 TF_octamer
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS

    Graphical View of Domain Structure for InterPro Entry P09086

    ProtoNet protein and cluster: P09086

    3 Blocks protein domains:
    IPB000327 POU domain
    IPB000972 Octamer-binding transcription factor signature
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086
    Similarity: Belongs to the POU transcription factor family. Class-2 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    POU2F2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO2F2_HUMAN, P09086
    Function: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates
    transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates
    transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter

         Genatlas biochemistry entry for POU2F2:
    POU domain,class 2,transcription factor 2,expressed in the immune system,also involved in the control of the
    forebrain development and the cell-cell signaling process underlying the hypothalamic regulation of female
    puberty

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0019904protein domain specific binding IEA--
    GO:0043565sequence-specific DNA binding IDA9242494
         
    POU2F2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for POU2F2:
     Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pou2f2):
     behavior/neurological  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  respiratory system 

    POU2F2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for POU2F2: Pou2f2tm1Bal Pou2f2tm1Lmc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for POU2F2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POU2F2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU2F2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU2F2 

    10/225 SABiosciences Target genes for POU2F2 (see all 225):
    ACADM ADCY3 ADH1C AGBL1 AMIGO3 ANKRD39 AOAH AP2A2 AP3S1 AQP7P1

    miRNA
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    miRTarBase miRNAs that target POU2F2:
    hsa-mir-9 (MIRT000639)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU2F2
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate POU2F2 (see all 92):
    hsa-miR-218-1* hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3148 hsa-miR-3612 hsa-miR-3622a-5p hsa-miR-4289 hsa-miR-663
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for POU2F2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development Glucocorticoid receptor signaling
    Development Glucocorticoid receptor signaling1.00
    2B cell receptor signaling pathway
    BCR signaling pathway0.42
    3SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for POU2F2
        Development Glucocorticoid receptor signaling


    1 GeneGo (Thomson Reuters) Pathway for POU2F2
        Development Glucocorticoid receptor signaling

    2 BioSystems Pathways for POU2F2
        SIDS Susceptibility Pathways
    BCR signaling pathway



    POU2F2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU2F2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/17 Interacting proteins for POU2F2 (P090863 ENSP000003739924) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MNAT1P519483, ENSP000002612454I2D: score=3 STRING: ENSP00000261245
    NR3C1P041503, ENSP000002315094I2D: score=3 STRING: ENSP00000231509
    XRCC6P129563, ENSP000003522574I2D: score=3 STRING: ENSP00000352257
    TBPP202263, ENSP000002303544I2D: score=2 STRING: ENSP00000230354
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002335mature B cell differentiation IEA--
    GO:0002380immunoglobulin secretion involved in immune response IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS9442393
    GO:0006959humoral immune response TAS9442393

    POU2F2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POU2F2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for POU2F2 (PO2F2)

    7 Novoseek inferred chemical compound relationships for POU2F2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    okadaic acid 14.8 1 10727398 (1)
    oligonucleotide 0 2 8026890 (1), 11368023 (1)
    steroid 0 1 10433239 (1)
    tyrosine 0 5 8672399 (4)
    glutamate 0 8 14756804 (4), 16787415 (1), 1358756 (1)
    gnrh 0 1 11036938 (1)
    serine 0 1 2302733 (1)

    Search CenterWatch for drugs/clinical trials and news about POU2F2 / PO2F2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POU2F2 gene (4 alternative transcripts): 
    NM_001207025.2  NM_001207026.1  NM_001247994.1  NM_002698.4  

    Unigene Cluster for POU2F2:

    POU class 2 homeobox 2
    Hs.147381  [show with all ESTs]
    Unigene Representative Sequence: NM_001207025
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000389341(uc002osn.3 uc002osq.3) ENST00000533720 ENST00000560804
    ENST00000526816 ENST00000529067 ENST00000534559 ENST00000533548 ENST00000560558
    ENST00000560398 ENST00000529952(uc002osr.2) ENST00000598842 ENST00000528894
    ENST00000526831 ENST00000530982 ENST00000531773 ENST00000524801 ENST00000532176
    ENST00000558596
    miRNA
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    hsa-miR-218-1* hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3148 hsa-miR-3612 hsa-miR-3622a-5p hsa-miR-4289 hsa-miR-663
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    Additional mRNA sequence: 

    AL833648.1 BC006101.1 BT007438.1 M22596.1 M36542.1 M36653.1 M36718.1 M36772.1 
    X13809.1 X13810.1 X53468.1 X53469.1 

    16 DOTS entries:

    DT.100785009  DT.99990511  DT.95069801  DT.100785010  DT.121453175  DT.91700060  DT.413141  DT.100785013 
    DT.413142  DT.413561  DT.65286027  DT.86836027  DT.91741185  DT.95069804  DT.97762188  DT.97775242 

    24/219 AceView cDNA sequences (see all 219):

    X13809 AA832036 BC006101 AA884256 AI359226 BM810914 AW135115 CF137658 
    BM452058 AI364649 BU428722 M36718 AA805083 AA417604 CA307156 M22596 
    AA400730 BE465551 AA749285 BX100387 AA805157 CR604513 AI208828 AW166309 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for POU2F2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                                      -           -     -     -                 -     -                                                     -           -   
    SP2:                                      -           -     -     -                 -                                                                           
    SP3:                                      -           -                             -                                                                           
    SP4:                                      -           -     -     -                                                                                             
    SP5:                                                        -     -                 -                                                                           

    ExUns: 19
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for POU2F2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU2F2 expression in normal human tissues (normalized intensities)      POU2F2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGAGATGA
    POU2F2 Expression
    About this image


    POU2F2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Lymph (Hematopoietic System)    fully expand to see all 4 entries
             lymph node ; non-germinal center cells   
             LYMPH NODE   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Ovary (Reproductive System)
             oocyte   

    See POU2F2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POU2F2

    SOURCE GeneReport for Unigene cluster: Hs.147381

    UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086
    Tissue specificity: Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the
    immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147

        SABiosciences Expression via Pathway-Focused PCR Arrays including POU2F2: 
              T Helper Cell Differentiation in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for POU2F2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou2f21 , 5 POU domain, class 2, transcription factor 21, 5 94.6(n)1
    98.45(a)1
      7 (13.73 cM)5
    189871  NM_001163554.11  NP_001157026.11 
     250919095 
    lizard
    (Anolis carolinensis)
    Reptilia POU2F26
    Uncharacterized protein
    46(a)
    1 ↔ 1
    GL343909.1(90878-109230)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005349341 POU domain, class 2, transcription factor 2-like 66.98(n)
    70.26(a)
      100534934  XM_003200146.1  XP_003200194.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nub3 neuroblast determination transcription
    factor
    74(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for POU2F2 (if available)
    TreeFam Gene Tree for POU2F2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POU2F2 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F12  POU3F42  POU1F12  POU3F32  
    POU4F32  POU3F22  POU5F1B2  POU4F12  POU2F12  POU6F12  POU5F12  
    14 SIMAP similar genes for POU2F2 using alignment to 13 protein entries:     PO2F2_HUMAN (see all proteins):
    OCT-2    OCT6    POU2F3    POU6F1    POU2F1    POU1F1
    POU5F1P4    POU3F1    POU5F1P1    POU5F1B    POU4F3    POU3F2
    POU5F1    POU3F4

    POU2F2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/728 SNPs in POU2F2 are shown (see all 728)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs129730441,2
    A--42597161(+) tatatA/Tttttt 4 -- int10--------
    rs1906209721,2
    --42779628(+) TAATTG/TTTTTT 3 -- ds50010--------
    rs2018640101,2
    C--42779640(+) TTTTG-/TTTTTT 3 -- ds50010--------
    rs1399787441,2
    C--42779656(+) TTTTTA/GGACAA 3 -- ds50010--------
    rs124602721,2
    H--42779706(+) attacA/Ggttca 3 -- ds50010--------
    rs1418233071,2
    --42780197(+) TCAGAC/TGGAAC 3 -- ut310--------
    rs129921,2
    C--42780230(+) AGGATG/TGAGGA 3 -- ut313Minor allele frequency- T:0.00MN NA 188
    rs37606421,2
    C,F,H--42780353(+) GGTGGT/CGAAAG 3 -- ut314Minor allele frequency- C:0.01EA NS NA 172
    rs1818623301,2
    --42780560(+) CTCTAC/TGAGTT 3 -- ut310--------
    rs2001275491,2
    C--42780569(+) TTGCC-/GAGAGAG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for POU2F2 (42590263 - 42700737 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for POU2F2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2496CNV Insertion18451855
    nsv520239CNV Loss19592680
    nsv911782CNV Loss21882294
    nsv911783CNV Loss21882294
    nsv522854CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164176    OMIM disorders: --

    20/25 diseases for POU2F2 (see all 25):    About MalaCards
    breast lymphoma    primary effusion lymphoma    plasmacytoma    merkel cell carcinoma
    herpes simplex    mediastinitis    b-cell lymphomas    myeloma
    diffuse large b-cell lymphoma    conjunctivitis    papilloma    kaposi's sarcoma
    anaplastic large cell lymphoma    acute lymphoblastic leukemia    multiple myeloma    acute myeloid leukemia
    lymphoblastic leukemia    sarcoma    hodgkin's lymphoma    myeloid leukemia


    POU2F2 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for POU2F2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    latent infection 54.1 3 8396817 (1), 8139923 (1), 1654947 (1)
    lymphoma b-cell 52.6 3 11904338 (1), 16778825 (1)
    herpes simplex 45 3 8129727 (1), 8645173 (1), 7733899 (1)
    lymphoma 41.4 17 11904338 (2), 16186795 (2), 11591767 (2), 7600290 (1) (see all 8)
    plasmacytoma 21.7 2 11591767 (2)
    hodgkin disease 19.3 2 14608905 (2)
    myeloma 14.5 4 7600290 (2), 2107075 (1), 9598983 (1)
    lymphoma non-hodgkins 0.603 2 11904338 (1), 14608905 (1)
    tumors 0 2 1620122 (1), 19504395 (1)

    Genetic Association Database (GAD): POU2F2
    Human Genome Epidemiology (HuGE) Navigator: POU2F2 (5 documents)

    Export disorders for POU2F2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU2F2 gene, integrated from 9 sources (see all 174):
    (articles sorted by number of sources associating them with POU2F2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Short introns interrupting the Oct-2 POU domain may prevent recombination between POU family genes without interfering with potential POU domain 'shuffling' in evolution. (PubMed id 7888080)1, 2, 9 Matsuo K....Schaffner W. (1994)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. Contribution of organic cation transporter 2 (OCT2) t o cisplatin-induced nephrotoxicity. (PubMed id 19625999)1, 4 Filipski K.K....Sparreboom A. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter. (PubMed id 10480874)1, 2 Prefontaine G.G....Hache R.J.G. (1999)
    6. Solution structure of a POU-specific homeodomain: 3D-NMR studies of human B-cell transcription factor Oct-2. (PubMed id 7914745)1, 2 Sivaraja M.... Weiss M.A. (1994)
    7. Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells. (PubMed id 2328728)1, 2 Muller-Immergluck M.M.... Matthias P. (1990)
    8. A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. (PubMed id 2904653)1, 2 Mueller M.M.... Matthias P. (1988)
    9. A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein. (PubMed id 2904654)1, 2 Scheidereit C.... Roder R.G. (1988)
    10. A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain. (PubMed id 2901913)1, 2 Ko H.-S.... Staudt L.M. (1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5452 HGNC: 9213 AceView: POU2F2 Ensembl:ENSG00000028277 euGenes: HUgn5452
    ECgene: POU2F2 H-InvDB: POU2F2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POU2F2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POU2F2 gene:
    Search GeneIP for patents involving POU2F2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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