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Aliases for POU2F2 Gene

Aliases for POU2F2 Gene

  • POU Class 2 Homeobox 2 2 3 5
  • Lymphoid-Restricted Immunoglobulin Octamer-Binding Protein NF-A2 3 4
  • Octamer-Binding Transcription Factor 2 3 4
  • Octamer-Binding Protein 2 3 4
  • OTF-2 3 4
  • Oct-2 3 4
  • OTF2 3 4
  • OCT2 3 4
  • POU Domain, Class 2, Transcription Factor 2 3
  • POU Domain Class 2, Transcription Factor 2 2
  • Homeobox Protein 3

External Ids for POU2F2 Gene

Previous HGNC Symbols for POU2F2 Gene

  • OTF2

Previous GeneCards Identifiers for POU2F2 Gene

  • GC19M043234
  • GC19M042986
  • GC19M047271
  • GC19M047286
  • GC19M042592
  • GC19M039023

Summaries for POU2F2 Gene

Entrez Gene Summary for POU2F2 Gene

  • The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for POU2F2 Gene

POU2F2 (POU Class 2 Homeobox 2) is a Protein Coding gene. Diseases associated with POU2F2 include Papilloma and T-Cell/Histiocyte Rich Large B Cell Lymphoma. Among its related pathways are Development_Glucocorticoid receptor signaling and SIDS Susceptibility Pathways. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein domain specific binding. An important paralog of this gene is POU2F1.

UniProtKB/Swiss-Prot for POU2F2 Gene

  • Transcription factor that specifically binds to the octamer motif (5-ATTTGCAT-3). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU2F2 Gene

Genomics for POU2F2 Gene

Regulatory Elements for POU2F2 Gene

Enhancers for POU2F2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around POU2F2 on UCSC Golden Path with GeneCards custom track

Genomic Location for POU2F2 Gene

Chromosome:
19
Start:
42,086,110 bp from pter
End:
42,196,585 bp from pter
Size:
110,476 bases
Orientation:
Minus strand

Genomic View for POU2F2 Gene

Genes around POU2F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POU2F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POU2F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU2F2 Gene

Proteins for POU2F2 Gene

  • Protein details for POU2F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09086-PO2F2_HUMAN
    Recommended name:
    POU domain, class 2, transcription factor 2
    Protein Accession:
    P09086
    Secondary Accessions:
    • Q16648
    • Q7M4M8
    • Q9BRS4

    Protein attributes for POU2F2 Gene

    Size:
    479 amino acids
    Molecular mass:
    51209 Da
    Quaternary structure:
    • Interacts with NR3C1, AR and PGR.
    SequenceCaution:
    • Sequence=CAA32039.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for POU2F2 Gene

    Alternative splice isoforms for POU2F2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POU2F2 Gene

Post-translational modifications for POU2F2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for POU2F2 Gene

Domains & Families for POU2F2 Gene

Gene Families for POU2F2 Gene

Suggested Antigen Peptide Sequences for POU2F2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09086

UniProtKB/Swiss-Prot:

PO2F2_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the POU transcription factor family. Class-2 subfamily.
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 POU-specific domain.
Family:
  • Belongs to the POU transcription factor family. Class-2 subfamily.
genes like me logo Genes that share domains with POU2F2: view

Function for POU2F2 Gene

Molecular function for POU2F2 Gene

GENATLAS Biochemistry:
POU domain,class 2,transcription factor 2,expressed in the immune system,also involved in the control of the forebrain development and the cell-cell signaling process underlying the hypothalamic regulation of female puberty
UniProtKB/Swiss-Prot Function:
Transcription factor that specifically binds to the octamer motif (5-ATTTGCAT-3). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.

Gene Ontology (GO) - Molecular Function for POU2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9442393
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with POU2F2: view
genes like me logo Genes that share phenotypes with POU2F2: view

Animal Models for POU2F2 Gene

MGI Knock Outs for POU2F2:

Animal Model Products

CRISPR Products

Transcription Factor Targets for POU2F2 Gene

Selected GeneGlobe predicted Target genes for POU2F2
Targeted motifs for POU2F2 Gene
HOMER Transcription Factor Regulatory Elements motif POU2F2
  • Consensus sequence: ATATGCAAAT Submotif: canonical Cell Type: Bcell GEO ID: GSE21512

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for POU2F2 Gene

Localization for POU2F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU2F2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POU2F2 Gene COMPARTMENTS Subcellular localization image for POU2F2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for POU2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9242494
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with POU2F2: view

Pathways & Interactions for POU2F2 Gene

genes like me logo Genes that share pathways with POU2F2: view

Pathways by source for POU2F2 Gene

2 BioSystems pathways for POU2F2 Gene
2 Reactome pathways for POU2F2 Gene
1 GeneGo (Thomson Reuters) pathway for POU2F2 Gene

SIGNOR curated interactions for POU2F2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for POU2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002335 mature B cell differentiation IEA --
GO:0002380 immunoglobulin secretion involved in immune response IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9442393
GO:0006959 humoral immune response TAS 9442393
genes like me logo Genes that share ontologies with POU2F2: view

Drugs & Compounds for POU2F2 Gene

(4) Drugs for POU2F2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
dolutegravir Approved Pharma Enzyme, inhibitor 133

(4) Additional Compounds for POU2F2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with POU2F2: view

Transcripts for POU2F2 Gene

Unigene Clusters for POU2F2 Gene

POU class 2 homeobox 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POU2F2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - - -

ExUns: 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for POU2F2 Gene

GeneLoc Exon Structure for
POU2F2
ECgene alternative splicing isoforms for
POU2F2

Expression for POU2F2 Gene

mRNA expression in normal human tissues for POU2F2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for POU2F2 Gene

This gene is overexpressed in Whole Blood (x7.5) and Spleen (x5.3).

Protein differential expression in normal tissues from HIPED for POU2F2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.6), Blymphocyte (21.6), and Monocytes (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POU2F2 Gene



Protein tissue co-expression partners for POU2F2 Gene

NURSA nuclear receptor signaling pathways regulating expression of POU2F2 Gene:

POU2F2

SOURCE GeneReport for Unigene cluster for POU2F2 Gene:

Hs.147381

mRNA Expression by UniProt/SwissProt for POU2F2 Gene:

P09086-PO2F2_HUMAN
Tissue specificity: Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147.
genes like me logo Genes that share expression patterns with POU2F2: view

Primer Products

Orthologs for POU2F2 Gene

This gene was present in the common ancestor of animals.

Orthologs for POU2F2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia POU2F2 34
  • 95.89 (n)
  • 99.58 (a)
POU2F2 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pou2f2 34
  • 94.6 (n)
  • 98.45 (a)
Pou2f2 16
Pou2f2 35
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POU2F2 34
  • 99.85 (n)
  • 100 (a)
POU2F2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pou2f2 34
  • 93.45 (n)
  • 97.16 (a)
cow
(Bos Taurus)
Mammalia POU2F2 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POU2F2 35
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POU2F2 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pou2f2 34
  • 66.74 (n)
  • 71.62 (a)
zebrafish
(Danio rerio)
Actinopterygii pou2f2a 34
  • 65.42 (n)
  • 68.3 (a)
pou2f2a 35
  • 42 (a)
OneToMany
pou2f2b 35
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta nub 36
  • 74 (a)
pdm2 36
  • 73 (a)
nub 35
  • 18 (a)
ManyToMany
pdm2 35
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-6 36
  • 55 (a)
ceh-18 35
  • 23 (a)
OneToMany
Species where no ortholog for POU2F2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POU2F2 Gene

ENSEMBL:
Gene Tree for POU2F2 (if available)
TreeFam:
Gene Tree for POU2F2 (if available)

Paralogs for POU2F2 Gene

genes like me logo Genes that share paralogs with POU2F2: view

Variants for POU2F2 Gene

Sequence variations from dbSNP and Humsavar for POU2F2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10425402 -- 42,088,778(+) GCGGA(A/G)ATGCT utr-variant-3-prime
rs10425682 -- 42,088,922(+) GCCCA(A/G)CCCAA utr-variant-3-prime
rs3760642 -- 42,086,485(+) GGTGG(C/T)GAAAG utr-variant-3-prime
rs3786540 -- 42,109,043(+) ACTTT(A/G)GCTAT intron-variant
rs28391524 -- 42,106,098(+) TCTCT(C/T)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POU2F2 Gene

Variant ID Type Subtype PubMed ID
nsv2496 CNV insertion 18451855
nsv520239 CNV loss 19592680
nsv522854 CNV gain 19592680

Variation tolerance for POU2F2 Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POU2F2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POU2F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU2F2 Gene

Disorders for POU2F2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for POU2F2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
papilloma
  • papillomatosis
t-cell/histiocyte rich large b cell lymphoma
  • thrlbcl
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POU2F2

Genetic Association Database (GAD)
POU2F2
Human Genome Epidemiology (HuGE) Navigator
POU2F2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POU2F2
genes like me logo Genes that share disorders with POU2F2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POU2F2 Gene

Publications for POU2F2 Gene

  1. Short introns interrupting the Oct-2 POU domain may prevent recombination between POU family genes without interfering with potential POU domain 'shuffling' in evolution. (PMID: 7888080) Matsuo K. … Schaffner W. (Biol. Chem. Hoppe-Seyler 1994) 3 4 22 65
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  3. A high throughput embryonic stem cell screen identifies Oct-2 as a bifunctional regulator of neuronal differentiation. (PMID: 19270158) Theodorou E. … Snyder M. (Genes Dev. 2009) 3 22 65
  4. Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity. (PMID: 19625999) Filipski K.K. … Sparreboom A. (Clin. Pharmacol. Ther. 2009) 3 46 65
  5. Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression. (PMID: 16186795) Heckman C.A. … Boxer L.M. (Oncogene 2006) 3 22 65

Products for POU2F2 Gene

Sources for POU2F2 Gene

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