POU2F2 Gene

Aliases
for POU2F2 gene

Previous GC identifers: GC19M043234 GC19M042986 GC19M047271 GC19M047286 GC19M039023

Summaries
for POU2F2 gene

Genomic Views
for POU2F2 gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011109.16  

SwitchGear Promoter luciferase reporter plasmid: POU2F2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU2F2

POU2F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M042592:  view genomic region     (about GC identifiers)

Proteins
for POU2F2 gene

1 PDB 3D structure from and Proteopedia for POU2F2:

1HDP (3D)    

Explore the universe of human proteins at neXtProt for POU2F2: NX_P09086

Post-translational modifications:

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	Novus Biologicals POU2F2 Protein Novus Biologicals POU2F2 Lysates
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

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Protein Domains /
Families
for POU2F2 gene

ProtoNet protein and cluster: P09086

Function
for POU2F2 gene

		10/229 SABiosciences Target genes for POU2F2 (see all 229):
		ACADM ADCY3 ADH1C AGBL1 AMIGO3 ANKRD39 AOAH AP2A2 AP3S1 AQP7P1

miRNA Products:		miRTarBase miRNAs that target POU2F2: hsa-mir-9 (MIRT000639)
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		hsa-miR-218-1* hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3148 hsa-miR-3612 hsa-miR-3622a-5p hsa-miR-4289 hsa-miR-663
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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Pou2f2)

Pathways & Interactions
for POU2F2 gene

	Super-pathway	contained gene-specific pathways
1	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)	Development Glucocorticoid receptor signaling 0.27 Development_Glucocorticoid receptor signaling 0.27
2	SIDS Susceptibility Pathways	SIDS Susceptibility Pathways 1.00
3	B cell receptor signaling pathway	BCR signaling pathway 0.41

1 EMD Millipore Pathway for POU2F2

Development Glucocorticoid receptor signaling

1 GeneGo (Thomson Reuters) Pathway for POU2F2

Development Glucocorticoid receptor signaling

2 BioSystems Pathways for POU2F2

	SIDS Susceptibility Pathways
	BCR signaling pathway

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

Drugs & Compounds
for POU2F2 gene

Transcripts
for POU2F2 gene

Expression
for POU2F2 gene

POU2F2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGAGATGA

3 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainHypothalamus			Brain
	BrainThalamus			Brain
	Neural TubeDiencephalon			Neural Tube
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F2

Orthologs
for POU2F2 gene

Paralogs
for POU2F2 gene

Paralogs for POU2F2 gene

POU5F2²  POU6F2²  POU4F2²  POU2F3²  POU3F4²  POU3F1²  POU1F1²  POU4F3²  

POU3F3²  POU3F2²  POU5F1B²  POU2F1²  POU4F1²  POU5F1²  POU6F1²  

14 SIMAP similar genes for POU2F2 using alignment to 13 protein entries:     PO2F2_HUMAN (see all proteins):

OCT-2    OCT6    POU2F3    POU2F1    POU1F1    POU6F1

POU3F1    POU5F1P4    POU5F1P1    POU5F1B    POU4F3    POU3F2

POU3F4    POU5F1

POU2F2 for paralogs           About GeneDecksing

Genomic Variants
for POU2F2 gene

10/529 NCBI SNPs in POU2F2 are shown (see all 529)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs124602721,2	H	--	39020907(+)	attacA/Ggttca	3	--	ds5001		0	--	--	--	--
rs129921,2	C	--	39021431(+)	AGGATG/TGAGGA	3	--	ut31		3		MN NA	188
rs37606421,2	C,F,H	--	39021554(+)	GGTGGT/CGAAAG	3	--	ut31		4		EA NS NA	172
rs797310151,2	F,	--	39022610(+)	CACACC/ACACCC	3	--	ut31		1		WA	118
rs11527121,2	C,F,H,	--	39023021(+)	ACCAGA/CGTGTA	3	--	ut31		11		MN NS NA WA	1546
rs104254021,2	C,H	--	39023847(+)	GCGGAG/AATGCT	3	--	ut31		6		NS EA NA	420
rs104256821,2	C,F,H	--	39023991(+)	GCCCAG/ACCCAA	3	--	ut31		8		NS EA NA	1044
rs2011402491,2	C	--	39024186(+)	GGCTGG/TCAGGC	3	--	ut31		0	--	--	--	--
rs739328721,2	C,	--	39024193(+)	AGGCCC/GCACCC	3	--	ut31		2		WA	120
rs770745191,2		--	39024960(+)	GAGACA/GTGTCC	3	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for POU2F2 (42592650 - 42700737 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for POU2F2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POU2F2

DNA2.0 Custom Variant and Variant Library Synthesis for POU2F2

Disorders / Diseases
for POU2F2 gene

20/25 diseases for POU2F2

9 Novoseek disease relationships for POU2F2 gene    About this table

Publications
for POU2F2 gene

PubMed articles for POU2F2 gene integrated from 9 sources (see top 10): (articles sorted by number of sources associating them with POU2F2)

Utopia: connect your pdf to the dynamic world of online information

1. Short introns interrupting the Oct-2 POU domain may prevent recombination between POU family genes without interfering with potential POU domain 'shuffling' in evolution. (PubMed id 7888080)^{1, 2, 9} Matsuo K....Schaffner W. (1994)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
3. Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter. (PubMed id 10480874)^{1, 2} Prefontaine G.G....Hache R.J.G. (1999)
4. Solution structure of a POU-specific homeodomain: 3D-NMR studies of human B-cell transcription factor Oct-2. (PubMed id 7914745)^{1, 2} Sivaraja M.... Weiss M.A. (1994)
5. Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells. (PubMed id 2328728)^{1, 2} Muller-Immergluck M.M.... Matthias P. (1990)
6. A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. (PubMed id 2904653)^{1, 2} Mueller M.M.... Matthias P. (1988)
7. A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein. (PubMed id 2904654)^{1, 2} Scheidereit C.... Roder R.G. (1988)
8. A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain. (PubMed id 2901913)^{1, 2} Ko H.-S.... Staudt L.M. (1988)
9. The B-cell-specific Oct-2 protein contains POU box- and homeo box- type domains. (PubMed id 3265124)^{1, 2} Clerc R.G.... Sharp P.A. (1988)
10. Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression. (PubMed id 16186795)^{1, 9} Heckman C.A....Boxer L.M. (2006)
11. Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter. (PubMed id 1739980)^{2, 9} Tanaka M.... Herr W. (1992)
12. A high throughput embryonic stem cell screen identifies Oct-2 as a bifunctional regulator of neuronal differentiation. (PubMed id 19270158)^{1, 9} Theodorou E....Snyder M. (2009)
13. Human Oct-1L isoform has tissue-specific expression pattern similar to Oct-2. (PubMed id 12663137)^{1, 9} Luchina N.N.... Pankratova E.V. (2003)
14. NF-kappa B and Oct-2 synergize to activate the human 3' Igh hs4 enhancer in B cells. (PubMed id 14707079)^{1, 9} Sepulveda M.A....Birshtein B.K. (2004)
15. Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells. (PubMed id 11841448)^{1, 9} Nagy M.... Matthes T. (2002)
16. Critical role for the Oct-2/OCA-B partnership in Ig-secreting cells. (PubMed id 14662861)^{1, 9} Salas M. and Eckhardt L.A. (2003)
17. The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat. (PubMed id 9078256)^{1, 9} Liu Y.Z. and Latchman D.S. (1997)
18. Immunohistochemical expression of Mum-1, Oct-2 and Bcl -6 in systemic anaplastic large cell lymphomas. (PubMed id 22158496)¹ Saglam A. and Uner A.H. (2011)
19. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
20. B-cell transcription factors Pax-5, Oct-2, BOB.1, Bcl -6, and MUM1 are useful markers for the diagnosis of nodular lymphocyte predomi nant Hodgkin lymphoma. (PubMed id 21424034)¹ Herbeck R....IoniALA8 H. (2011)
21. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
22. Functional characterization of gefitinib uptake in no n-small cell lung cancer cell lines. (PubMed id 20363215)¹ Galetti M....Petronini P.G. (2010)
23. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
24. OCT-2 expression and OCT-2/BOB.1 co-expression predic t prognosis in patients with newly diagnosed acute myeloid leukemia. (PubMed id 20141429)¹ Advani A.S....Hsi E. (2010)
25. Involvement of the organic cation transporters in his tamine uptake into human vascular endothelial cells. (PubMed id 19271143)¹ Cerne K. and Krzan M. (2009)
26. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
27. Contribution of organic cation transporter 2 (OCT2) t o cisplatin-induced nephrotoxicity. (PubMed id 19625999)¹ Filipski K.K....Sparreboom A. (2009)
28. The effects of genetic polymorphisms in the organic c ation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. (PubMed id 19536068)¹ Tzvetkov M.V....BrockmAPller J. (2009)
29. Functional long-range interactions of the IgH 3' enhancers with the bcl-2 promoter region in t(14;18) lymphoma cells. (PubMed id 18695675)¹ Duan H....Boxer L.M. (2008)
30. Production of specific mRNA transcripts, usage of an alternate promoter, and octamer-binding transcription factors influence the surface expression levels of the HIV coreceptor CCR5 on primary T cells. (PubMed id 17442950)¹ Mummidi S....Ahuja S.K. (2007)
31. Alterations of loci encoding PU.1, BOB1, and OCT2 transcription regulators do not correlate with their suppressed expression in Hodgkin lymphoma. (PubMed id 15796964)¹ Cavazzini F....Wlodarska I. (2005)
32. Functional interaction of Oct transcription factors with the family of repeats in Epstein-Barr virus oriP. (PubMed id 15831936)¹ Almqvist J....Ernberg I. (2005)
33. S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. (PubMed id 12887926)¹ Zheng L.... Luo Y. (2003)
34. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
35. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase the binding activity and nuclear level of Oct-1 in mononuclear cells. (PubMed id 12144930)¹ Ortego M....Egido J. (2002)
36. Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping. (PubMed id 11583619)¹ Remenyi A....Wilmanns M. (2001)
37. The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase. (PubMed id 11279128)¹ Schild-Poulter C....Hache R.J. (2001)
38. Functional interaction between Oct-1 and retinoid X receptor. (PubMed id 10383413)¹ Kakizawa T....Hashizume K. (1999)
39. Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding. (PubMed id 10490647)¹ Wang J.M....Hache R.J. (1999)
40. High mobility group I/Y protein functions as a specif ic cofactor for Oct-2A: mapping of interaction domains. (PubMed id 9823775)¹ Abdulkadir S.A....Ono S.J. (1998)
41. The different alternatively spliced isoforms of the Oct-2 transcription factor repress the involucrin promoter in a cell type-specific manner. (PubMed id 9870616)¹ Chapman C.M. and Latchman D.S. (1998)
42. Recruitment of octamer transcription factors to DNA by glucocorticoid receptor. (PubMed id 9584182)¹ Prefontaine G.G....Hache R.J. (1998)
43. Coactivator OBF-1 makes selective contacts with both the POU-specific domain and the POU homeodomain and acts as a molecular clamp on DNA. (PubMed id 9819426)¹ Sauter P. and Matthias P. (1998)
44. Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation. (PubMed id 9242494)¹ Andersen B....Rosenfeld M.G. (1997)
45. Identification of target genes of the lymphoid-specific transcription factor Oct2. (PubMed id 9442393)¹ Pfisterer P....Wirth T. (1997)
46. The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors. (PubMed id 9368058)¹ Inamoto S....Roeder R.G. (1997)
47. Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor. (PubMed id 8902060)¹ Liu Y.Z....Latchman D.S. (1996)
48. High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors. (PubMed id 7720710)¹ Zwilling S....Wirth T. (1995)
49. The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP. (PubMed id 8202368)¹ Zwilling S....Wirth T. (1994)
50. Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules. (PubMed id 8156594)¹ Klemm J.D.... Pabo C.O. (1994)
51. Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA). (PubMed id 3072196)² Schreiber E.... Schaffner W. (1988)
52. Oct-2 facilitates functional preinitiation complex as sembly and is continuously required at the promoter for multiple rounds of tran scription. (PubMed id 8428575)⁹ Arnosti D.N....Schaffner W. (1993)
53. Induction of the POU domain transcription factor Oct-2 during T-cell activation by cognate antigen. (PubMed id 1620122)⁹ Kang S.M....Staudt L.M. (1992)
54. Phosphorylation of Oct-2 at sites located in the POU domain induces differential down-regulation of Oct-2 DNA-binding ability. (PubMed id 10727398)⁹ Pevzner V....Lipp M. (2000)
55. Positive and negative regulation of the composite octamer motif of the interleukin 2 enhancer by AP-1, Oct-2, and retinoic acid receptor. (PubMed id 7931079)⁹ de Grazia U....Gulino A. (1994)
56. Regulation and a possible stage-specific function of Oct-2 during pre-B-cell differentiation. (PubMed id 1922024)⁹ Miller C.L....Singh H. (1991)
57. Oct-2 regulates CD36 gene expression via a consensus octamer, which excludes the co-activator OBF-1. (PubMed id 11937630)⁹ Shore P....Corcoran L.M. (2002)
58. Unique function for carboxyl-terminal domain of Oct-2 in Ig-secreting cells. (PubMed id 11591767)⁹ Sharif M.N....Eckhardt L.A. (2001)
59. Oct-1 [corrected] and Oct-2 DNA-binding site specificity is regulated in vitro by different kinases. (PubMed id 8645173)⁹ Grenfell S.J....Thomas N.S. (1996)
60. Differentiation of human B-cell malignant lymphomas is independent of the octamer lymphoid specific binding factor (Oct-2). (PubMed id 1937571)⁹ Kossakowska A.E. and Urbanski S.J. (1991)
61. Constitutively expressed Oct-2 prevents immunoglobulin gene silencing in myeloma x T cell hybrids. (PubMed id 7600290)⁹ Radomska H.S....Eckhardt L.A. (1994)
62. Oct2 transactivation from a remote enhancer position requires a B-cell-restricted activity. (PubMed id 1620119)⁹ Annweiler A....Wirth T. (1992)
63. Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation. (PubMed id 2302733)⁹ Tanaka M. and Herr W. (1990)
64. The essential role of Oct-2 in LPS-induced expression of iNOS in RAW 264.7 macrophages and its regulation by trichostatin A. (PubMed id 19279235)⁹ Lu S.C....Chang S.F. (2009)
65. Differential transactivation potential of Oct1 and Oct2 is determined by additional B cell-specific activities. (PubMed id 8157005)⁹ Pfisterer P....Wirth T. (1994)
66. Differential positive control by Oct-1 and Oct-2: activation of a transcriptionally silent motif through Oct-1 and VP16 corecruitment. (PubMed id 8422989)⁹ Cleary M.A....Herr W. (1993)
67. Role of defective Oct-2 and OCA-B expression in immunoglobulin production and Kaposi's sarcoma-associated herpesvirus lytic reactivation in primary effusion lymphoma. (PubMed id 19224997)⁹ Di Bartolo D.L....Cesarman E. (2009)
68. Analysis of octamer-binding transcription factors Oct2 and Oct1 and their coactivator BOB.1/OBF.1 in lymphomas. (PubMed id 11904338)⁹ Saez A.I....Piris M.A. (2002)
69. Optimal Oct-2 affinity for an extended DNA site and the effect of GST fusion on site preference. (PubMed id 11368023)⁹ Rhee J.M....Turner E.E. (2001)
70. Transcription factor NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes. (PubMed id 9360945)⁹ Bendall H.H....Oltz E.M. (1997)
71. Differential regulation of genes encoding synaptic pr oteins by the Oct-2 transcription factor. (PubMed id 9427500)⁹ Deans Z.C....Latchman D.S. (1997)
72. The Oct-2 glutamine-rich and proline-rich activation domains can synergize with each other or duplicates of themselves to activate transcription. (PubMed id 8065338)⁹ Tanaka M....Herr W. (1994)
73. The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2. (PubMed id 2204815)⁹ Kamps M.P....Baltimore D. (1990)
74. Oct-2 DNA binding transcription factor: functional consequences of phosphorylation and glycosylation. (PubMed id 16431844)⁹ Ahmad I....Nasir-ud-Din . (2006)
75. DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE. (PubMed id 16103132)⁹ Malin S....Pettersson S. (2005)
76. Overexpression of octamer transcription factors 1 or 2 alone has no effect on HIV-1 transcription in primary human CD4 T cells. (PubMed id 15051391)⁹ Zhang M....Cron R.Q. (2004)
77. Glutamate regulates Oct-2 DNA-binding activity through alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors in cultured chick Bergmann glia cells. (PubMed id 14756804)⁹ Mendez J.A....Ortega A. (2004)
78. The B-cell transcription factors BSAP, Oct-2, and BOB.1 and the pan-B-cell markers CD20, CD22, and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. (PubMed id 14608905)⁹ Browne P....Chan J.A. (2003)
79. The Oct-2 POU domain gene in the neuroendocrine brain: a transcriptional regulator of mammalian puberty. (PubMed id 10433239)⁹ Ojeda S.R....Ma Y.J. (1999)
80. An octamer element functions as a regulatory element in the differentiation-responsive CD11c integrin gene promoter: OCT-2 inducibility during myelomonocytic differentiation. (PubMed id 9190935)⁹ Lopez-Rodriguez C....Corbi A.L. (1997)
81. Direct evidence that the POU family transcription factor Oct-2 represses the cellular tyrosine hydroxylase gene in neuronal cells. (PubMed id 8672399)⁹ Deans Z....Latchman D.S. (1995)
82. Cell type- and stage-specific expression of the CD20/B1 antigen correlates with the activity of a diverged octamer DNA motif present in its promoter. (PubMed id 7680653)⁹ Thevenin C....Kehrl J.H. (1993)
83. Identification of sites for distinct DNA binding proteins including Oct-1 and Oct-2 in the Cr2 gene. (PubMed id 1534100)⁹ Christensen S.M....Weis J.H. (1992)
84. A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain. (PubMed id 1358756)⁹ Lai J.S....Herr W. (1992)
85. Extinction of an immunoglobulin kappa promoter in cell hybrids is mediated by the octamer motif and correlates with suppression of Oct-2 expression. (PubMed id 2110507)⁹ Junker S....Matthias P. (1990)
86. Primary diffuse large B-cell lymphoma of the breast. (PubMed id 17690512)⁹ Kuroda H....Itoyama S. (2007)
87. CD86 and beta2-adrenergic receptor signaling pathways, respectively, increase Oct-2 and OCA-B Expression and binding to the 3'-IgH enhancer in B cells. (PubMed id 15024018)⁹ Podojil J.R....Sanders V.M. (2004)
88. The human involucrin gene is transcriptionally repressed through a tissue-specific silencer element recognized by Oct-2. (PubMed id 15120610)⁹ Azuara-Liceaga E....Lopez-Bayghen E. (2004)
89. Reconstitution of transcriptional activation domains by reiteration of short peptide segments reveals the modular organization of a glutamine-rich activation domain. (PubMed id 8065339)⁹ Tanaka M. and Herr W. (1994)
90. Mouse Oct-1 contains a composite homeodomain of human Oct-1 and Oct-2. (PubMed id 8441632)⁹ Suzuki N....Scholer H.R. (1993)
91. Transforming growth factor-beta suppresses human B lymphocyte Ig production by inhibiting synthesis and the switch from the membrane form to the secreted form of Ig mRNA. (PubMed id 1903417)⁹ Kehrl J.H....Fauci A.S. (1991)
92. The B-cell and neuronal forms of the octamer-binding protein Oct-2 differ in DNA-binding specificity and functional activity. (PubMed id 2072899)⁹ Dent C.L....Latchman D.S. (1991)
93. Activation of octamer-containing promoters by either octamer-binding transcription factor 1 (OTF-1) or OTF-2 and requirement of an additional B-cell-specific component for optimal transcription of immunoglobulin promoters. (PubMed id 2123291)⁹ Pierani A....Roeder R.G. (1990)
94. BOB.1 of the channel catfish, Ictalurus punctatus: not a transcriptional coactivator? (PubMed id 19041136)⁹ Richard M.L....Warr G.W. (2009)
95. Epstein-Barr virus latency switch in human B-cells: a physico-chemical model. (PubMed id 17764547)⁹ Werner M....Aurell E. (2007)
96. Characterization of an Oct1 orthologue in the channel catfish, Ictalurus punctatus: a negative regulator of immunoglobulin gene transcription? (PubMed id 17266766)⁹ Lennard M.L....Warr G.W. (2007)
97. Glutamate-induced octamer DNA binding and transcriptional control in cultured radial glia cells. (PubMed id 16787415)⁹ Lopez-Bayghen E....Ortega A. (2006)
98. Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma. (PubMed id 16778825)⁹ Hoefnagel J.J....Vermeer M.H. (2006)
99. Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator OBF-1. (PubMed id 8657574)⁹ Schubart D.B....Matthias P. (1996)
100. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. (PubMed id 7623806)⁹ Luo Y. and Roeder R.G. (1995)
101. The C-terminus of the B cell activator Oct-2 functions as an activation domain in yeast. (PubMed id 7811293)⁹ Mead J....Ludmerer S.W. (1994)
102. The Oct-2 transcription factor represses tyrosine hydroxylase expression via a heptamer TAATGARAT-like motif in the gene promoter. (PubMed id 7908738)⁹ Dawson S.J....Latchman D.S. (1994)
103. Alternative splicing of the Oct-2 transcription facto r RNA is differentially regulated in neuronal cells and B cells and results in protein isoforms with opposite effects on the activity of octamer/TAATGARAT-con taining promoters. (PubMed id 1281152)⁹ Lillycrop K.A. and Latchman D.S. (1992)
104. Oct-1 and Oct-2 potentiate functional interactions of a transcription factor with the proximal sequence element of small nuclear RNA genes. (PubMed id 1535687)⁹ Murphy S....Roeder R.G. (1992)
105. Interferon-alpha treatment of Daudi cells down-regula tes the octamer binding transcription/DNA replication factors Oct-1 and Oct-2. (PubMed id 1939139)⁹ Dent C.L....Thomas N.S. (1991)
106. The octamer-binding protein Oct-2 represses HSV immediate-early genes in cell lines derived from latently infectable sensory neurons. (PubMed id 1654947)⁹ Lillycrop K.A....Latchman D.S. (1991)
107. Identification of a novel factor that interacts with an immunoglobulin heavy-chain promoter and stimulates transcription in conjunction with the lymphoid cell-specific factor OTF2. (PubMed id 2109187)⁹ Yoza B.K. and Roeder R.G. (1990)
108. Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution. (PubMed id 1967834)⁹ Petryniak B....Thompson C.B. (1990)
109. Extinction of Ig genes expression in myeloma x fibroblast somatic cell hybrids is accompanied by repression of the oct-2 gene encoding a B-cell specific transcription factor. (PubMed id 2107075)⁹ Bergman Y....Laskov R. (1990)
110. IL-21 imposes a type II EBV gene expression on type I II and type I B cells by the repression of C- and activation of LMP-1-promoter. (PubMed id 20080768)⁹ Kis L.L....Klein E. (2010)
111. A unique case of B cell lymphoma relapsing as CD4/CD5 6 blastic neoplasm. (PubMed id 19504395)⁹ Au W.Y....Liang R. (2009)
112. POU2AF1, an amplification target at 11q23, promotes growth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor, TNFRSF17. (PubMed id 17621271)⁹ Zhao C....Inazawa J. (2008)
113. Downregulation of internal enhancer activity contributes to abnormally low immunoglobulin expression in the MedB-1 mediastinal B-cell lymphoma cell line. (PubMed id 15682441)⁹ Ritz O....Wirth T. (2005)
114. Mammalian transcription activation domains of VP16, A P2 and CTF activate transcription in a whole cell extract from Schizosaccharomy ces pombe through the SRB/mediator. (PubMed id 15942925)⁹ Tamayo E....Maldonado E. (2005)
115. Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity. (PubMed id 16061936)⁹ Goffin V....Van Lint C. (2005)
116. The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombination. (PubMed id 15252056)⁹ Kim E.C....Casali P. (2004)
117. OBF1 enhances transcriptional potential of Oct1. (PubMed id 12727885)⁹ Lins K....Scholer H.R. (2003)
118. Micronodular T-cell/histiocyte-rich large B-cell lymphoma of the spleen: histology, immunophenotype, and differential diagnosis. (PubMed id 12826882)⁹ Dogan A....Isaacson P.G. (2003)
119. Regulation of oct-1 gene transcription is different in lymphoid and non-lymphoid cells. (PubMed id 14505828)⁹ Zhenilo S....Polanovsky O. (2003)
120. Octamer proteins inhibit IL-4 gene transcription in normal human CD4 T cells. (PubMed id 11781715)⁹ Cron R.Q....Lewis D.B. (2001)
121. Cutting edge: lack of peripheral B cells and severe agammaglobulinemia in mice simultaneously lacking Bruton's tyrosine kinase and the B cell-specific transcriptional coactivator OBF-1. (PubMed id 10604987)⁹ Schubart D.B....Matthias P. (2000)
122. Expression of B cell-associated transcription factors in B-cell precursor acute lymphoblastic leukemia cells: association with PU.1 expression, phenotype, and immunogenotype. (PubMed id 10905058)⁹ Nishii K....Shiku H. (2000)
123. Glia-to-neuron signaling and the neuroendocrine control of female puberty. (PubMed id 11036938)⁹ Ojeda S.R....Prevot V. (2000)
124. Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription. (PubMed id 10828057)⁹ Wolstein O.... Dikstein R. (2000)
125. POU family transcription factors in the nervous system. (PubMed id 10199551)⁹ Latchman D.S. (1999)
126. Ionizing radiation stimulates octamer factor DNA binding activity in human carcinoma cells. (PubMed id 10544969)⁹ Meighan-Mantha R.L....Kasid U. (1999)
127. The activity of the human interleukin-5 conserved lymphokine element 0 is regulated by octamer factors in human cells. (PubMed id 10491186)⁹ Thomas M.A....Sanderson C.J. (1999)
128. Examination of POU homeobox gene expression in human breast cancer cells. (PubMed id 10077160)⁹ Jin T....Goss P.E. (1999)
129. POU domain factors in neural development. (PubMed id 10026784)⁹ Schonemann M.D....Rosenfeld M.G. (1998)
130. Oct-1 promoter region contains octamer sites and TAAT motifs recognized by Oct proteins. (PubMed id 9598983)⁹ Pankratova E.V....Polanovasky O.L. (1998)
131. Five discrete cis-active domains direct cell type-specific transcription of the vasoactive intestinal peptide (VIP) gene. (PubMed id 9642274)⁹ Hahm S.H. and Eiden L.E. (1998)
132. Transcription factor effects on chromosome constitution of cell hybrids. (PubMed id 9925930)⁹ Hines M.D....Eckhardt L.A. (1998)
133. Extinction of immunoglobulin gene expression in B cells upon fusion with HeLa cells is preceded by rapid nuclear depletion of essential transcription factors and is accompanied by widespread inactivation of genes expressed in a B cell-specific manner. (PubMed id 9372447)⁹ Junker S....Matthias P. (1997)
134. Cysteine 50 of the POU H domain determines the range of targets recognized by POU proteins. (PubMed id 9207034)⁹ Stepchenko A.G....Pankratova E.V. (1997)
135. Cloning and analysis of the promoter region of CCR5, a coreceptor for HIV-1 entry. (PubMed id 9548484)⁹ Moriuchi H....Fauci A.S. (1997)
136. Characterization of constitutive and inducible transcription factors binding to the P2 NF-AT site in the human interleukin-4 promoter. (PubMed id 9133600)⁹ Li-Weber M....Krammer P.H. (1997)
137. POU-domain factor expression in the trigeminal gangli on and implications for herpes virus regulation. (PubMed id 9116190)⁹ Turner E.E....Rosenfeld M.G. (1996)
138. Prostaglandin E2 inhibits the interleukin-2 promoter activity through down-regulation of the Oct-dependent transcription of the octamer motif. (PubMed id 8964085)⁹ Felli M.P....Gulino A. (1996)
139. Sequence-specific DNA binding of the B-cell-specific coactivator OCA-B. (PubMed id 8769650)⁹ Cepek K.L....Sharp P.A. (1996)
140. Induction of the Oct-2 transcription factor in primary sensory neurons during inflammation is nerve growth factor-dependent. (PubMed id 8929970)⁹ Ensor E....Latchman D.S. (1996)
141. Regulation of human involucrin promoter activity by POU domain proteins. (PubMed id 8663077)⁹ Welter J.F....Eckert R.L. (1996)
142. Binding and cooperative interactions between two B cell-specific transcriptional coactivators. (PubMed id 8676072)⁹ Fontes J.D....Peterlin B.M. (1996)
143. The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation. (PubMed id 8654375)⁹ Gstaiger M....Schaffner W. (1996)
144. Octamer independent activation of transcription from the kappa immunoglobulin germline promoter. (PubMed id 8972869)⁹ Prabhu A....Van Ness B. (1996)
145. Activation and repression of gene expression by POU family transcription factors. (PubMed id 8735273)⁹ Latchman D.S. (1996)
146. Specific up-regulation of the POU domain transcriptio n factor Oct-2 following axotomy. (PubMed id 8728480)⁹ Begbie J.L....Latchman D.S. (1996)
147. Structure, organization, and transcription units of the human alpha- platelet-derived growth factor receptor gene, PDGFRA. (PubMed id 8586421)⁹ Kawagishi J. and Ku T. (1995)
148. Activation of the herpes simplex virus immediate-early gene promoters by neuronally expressed POU family transcription factors. (PubMed id 7733899)⁹ Lillycrop K.A....Latchman D.S. (1995)
149. Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter. (PubMed id 7642649)⁹ Nakshatri H....Currie R.A. (1995)
150. Down regulation of the octamer binding protein Oct-1 during growth arrest and differentiation of a neuronal cell line. (PubMed id 7707877)⁹ Lakin N.D....Latchman D.S. (1995)
151. Involvement of the Ets family factor PU.1 in the acti vation of immunoglobulin promoters. (PubMed id 7822329)⁹ Schwarzenbach H....Matthias P. (1995)
152. Cloning, sequencing and expression of two isoforms of the murine oct-1 transcription factor. (PubMed id 7711063)⁹ Jaffe J....Laskov R. (1995)
153. Role of Oct-2 in immunoglobulin gene silencing. (PubMed id 7486513)⁹ Radomska H.S....Eckhardt L.A. (1995)
154. Functional interaction between different isoforms of the Oct-2 transcription factor expressed in neuronal cells. (PubMed id 8129727)⁹ Lillycrop K.A....Latchman D.S. (1994)
155. A nonconsensus octamer-recognition sequence (TAATGARAT-motif) identifies a novel DNA binding protein in human Merkel cell carcinoma cell lines. (PubMed id 8026890)⁹ Thomson J.A....Parsons P.G. (1994)
156. Inhibition of herpes simplex virus infection by ectopic expression of neuronal splice variants of the Oct-2 transcription factor. (PubMed id 8139923)⁹ Lillycrop K.A....Latchman D.S. (1994)
157. Enhanced activation of the human histone H2B promoter by an Oct-1 variant generated by alternative splicing. (PubMed id 8227066)⁹ Das G. and Herr W. (1993)
158. Ras oncogene transformation of human B lymphoblasts is associated with lymphocyte activation and with a block of differentiation. (PubMed id 8423993)⁹ Sirinian M.I....Nasi S. (1993)
159. Transactivation of the human papilloma virus 16 octamer motif by the octamer binding protein Oct-2 requires both the N and C terminal activation domains. (PubMed id 8233784)⁹ Morris P.J....Latchman D.S. (1993)
160. Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. (PubMed id 8234287)⁹ Bhargava A.K.... Weissman S.M. (1993)
161. Gene transcription in differentiating immature T cell receptor(neg) thymocytes resembles antigen-activated mature T cells. (PubMed id 8376926)⁹ ZA_A+iga-PflA1cker J.C....Lenardo M.J. (1993)
162. The octamer binding protein Oct-2 inhibits transactivation of the herpes simplex virus immediate-early genes by the virion protein Vmw65. (PubMed id 8396817)⁹ Lillycrop K.A....Latchman D.S. (1993)
163. Conserved cysteine residues of Oct-2 POU domain confer sensitivity to oxidation but are dispensable for sequence-specific DNA binding. (PubMed id 8504164)⁹ Rigoni P....Arnosti D.N. (1993)
164. A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells. (PubMed id 1383937)⁹ Lillycrop K.A....Latchman D.S. (1992)
165. Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations. (PubMed id 1495986)⁹ Lai J.S. and Herr W. (1992)
166. Okadaic acid is a potent inducer of AP-1, NF-kappa B, and tumor necrosis factor-alpha in human B lymphocytes. (PubMed id 1520341)⁹ Rieckmann P....Kehrl J.H. (1992)
167. Characterization of two Drosophila POU domain genes, related to oct-1 and oct-2, and the regulation of their expression patterns. (PubMed id 1685891)⁹ Lloyd A. and Sakonju S. (1991)
168. Transcription factor requirements for U2 snRNA-encoding gene activation in B lymphoid cells. (PubMed id 1765275)⁹ Janson L. and Pettersson U. (1991)
169. Promoters with the octamer DNA motif (ATGCAAAT) can be ubiquitous or cell type-specific depending on binding affinity of the octamer site and Oct-factor concentration. (PubMed id 2014164)⁹ Kemler I....Schaffner W. (1991)
170. Octamer-binding proteins in diverse hemopoietic cells. (PubMed id 2106071)⁹ Cockerill P.N. and Klinken S.P. (1990)
171. The DNA binding domain (POU domain) of transcription factor oct-1 suffices for stimulation of DNA replication. (PubMed id 2347308)⁹ Verrijzer C.P....Van der Vliet P.C. (1990)
172. A conserved sequence block in the murine and human T cell receptor Jalpha loci interacts with developmentally regulated nucleoprotein complexes in vitro and associates with GATA-3 and octamer-binding factors in vivo. (PubMed id 11385613)⁹ Chen M.L. and Kuo C.L. (2001)

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