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POU2F2 Gene

protein-coding   GIFtS: 60
GCID: GC19M042592

POU Class 2 Homeobox 2

(Previous names: POU domain class 2, transcription factor 2)
(Previous symbol: OTF2)
  See POU2F2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
POU Class 2 Homeobox 21 2     OTF-22 3
OTF21 2 3 5     Oct-22 3
OCT22 3 5     POU Domain Class 2, Transcription Factor 21
Lymphoid-Restricted Immunoglobulin Octamer-Binding Protein NF-A22 3     Homeobox Protein2
Octamer-Binding Protein 22 3     POU Domain, Class 2, Transcription Factor 22
Octamer-Binding Transcription Factor 22 3     

External Ids:    HGNC: 92131   Entrez Gene: 54522   Ensembl: ENSG000000282777   OMIM: 1641765   UniProtKB: P090863   

Export aliases for POU2F2 gene to outside databases

Previous GC identifers: GC19M043234 GC19M042986 GC19M047271 GC19M047286 GC19M039023


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POU2F2 Gene:
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The
encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in
immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for POU2F2 Gene:
POU2F2 (POU class 2 homeobox 2) is a protein-coding gene. Diseases associated with POU2F2 include nodular lymphocyte predominant hodgkin lymphoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein domain specific binding. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086
Function: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates
transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates
transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the POU2F2 gene promoter:
         NRSF form 1   NRSF form 2   Evi-1   E47   HNF-4alpha1   PPAR-gamma1   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOU2F2 promoter sequence
   Search Chromatin IP Primers for POU2F2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU2F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

POU2F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU2F2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M042592:  view genomic region     (about GC identifiers)

Start:
42,590,263 bp from pter      End:
42,700,737 bp from pter
Size:
110,475 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086 (See protein sequence)
Recommended Name: POU domain, class 2, transcription factor 2  
Size: 479 amino acids; 51209 Da
Subunit: Interacts with NR3C1, AR and PGR
Sequence caution: Sequence=CAA32039.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for POU2F2:
1HDP (3D)    
Secondary accessions: Q16648 Q7M4M8 Q9BRS4
Alternative splicing: 5 isoforms:  P09086-1   P09086-2   P09086-3   P09086-4   P09086-5   (Incomplete sequence)

Explore the universe of human proteins at neXtProt for POU2F2: NX_P09086

Explore proteomics data for POU2F2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POU2F2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001193954.1  NP_001193955.1  NP_001234923.1  NP_002689.1  

    ENSEMBL proteins: 
     ENSP00000373992   ENSP00000437221   ENSP00000452930   ENSP00000431603   ENSP00000437224  
     ENSP00000436100   ENSP00000453995   ENSP00000454179   ENSP00000453255   ENSP00000436988  
     ENSP00000471890   ENSP00000475664   ENSP00000476062   ENSP00000476240   ENSP00000339369  

    POU2F2 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for POU2F2 

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    Search eBioscience for ELISAs for POU2F2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POU: Homeoboxes / POU class

    Selected InterPro protein domains (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR000972 TF_octamer
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS

    Graphical View of Domain Structure for InterPro Entry P09086

    ProtoNet protein and cluster: P09086

    3 Blocks protein domains:
    IPB000327 POU domain
    IPB000972 Octamer-binding transcription factor signature
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086
    Similarity: Belongs to the POU transcription factor family. Class-2 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    Find genes that share domains with POU2F2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO2F2_HUMAN, P09086
    Function: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates
    transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates
    transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter

         Genatlas biochemistry entry for POU2F2:
    POU domain,class 2,transcription factor 2,expressed in the immune system,also involved in the control of the
    forebrain development and the cell-cell signaling process underlying the hypothalamic regulation of female
    puberty

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0019904protein domain specific binding IEA--
    GO:0043565sequence-specific DNA binding IDA9242494
         
    Find genes that share ontologies with POU2F2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for POU2F2:
     Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pou2f2):
     behavior/neurological  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  respiratory system 

    Find genes that share phenotypes with POU2F2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for POU2F2: Pou2f2tm1Bal Pou2f2tm1Lmc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POU2F2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for POU2F2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU2F2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU2F2

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  ATATGCAAAT 

    miRNA
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    miRTarBase miRNAs that target POU2F2:
    hsa-mir-9-5p (MIRT000639)

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    Selected qRT-PCR Assays for microRNAs that regulate POU2F2 (see all 92):
    hsa-miR-218-1* hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3148 hsa-miR-3612 hsa-miR-3622a-5p hsa-miR-4289 hsa-miR-663
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat POU2F2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: POU2F2 (NM_002698)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU2F2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PO2F2_HUMAN, P09086: Cytoplasm (By similarity). Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9242494
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with POU2F2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POU2F2 About    
    See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway (KEGG)
    BCR signaling pathway0.42
    2SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways
    3Development Glucocorticoid receptor signaling
    Development Glucocorticoid receptor signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for POU2F2
        Development Glucocorticoid receptor signaling

    2 BioSystems Pathways for POU2F2
        SIDS Susceptibility Pathways
    BCR signaling pathway


        Pathway & Disease-focused RT2 Profiler PCR Arrays including POU2F2: 
              T Helper Cell Differentiation in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for POU2F2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for POU2F2 (P090863 ENSP000003739924) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MNAT1P519483, ENSP000002612454I2D: score=3 STRING: ENSP00000261245
    NR3C1P041503, ENSP000002315094I2D: score=3 STRING: ENSP00000231509
    XRCC6P129563, ENSP000003522574I2D: score=3 STRING: ENSP00000352257
    TBPP202263, ENSP000002303544I2D: score=2 STRING: ENSP00000230354
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002335mature B cell differentiation IEA--
    GO:0002380immunoglobulin secretion involved in immune response IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS9442393
    GO:0006959humoral immune response TAS9442393

    Find genes that share ontologies with POU2F2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POU2F2 (PO2F2)

    7 Novoseek inferred chemical compound relationships for POU2F2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    okadaic acid 14.8 1 10727398 (1)
    oligonucleotide 0 2 8026890 (1), 11368023 (1)
    steroid 0 1 10433239 (1)
    tyrosine 0 5 8672399 (4)
    glutamate 0 8 14756804 (4), 16787415 (1), 1358756 (1)
    gnrh 0 1 11036938 (1)
    serine 0 1 2302733 (1)



    Find genes that share compounds with POU2F2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POU2F2 gene (4 alternative transcripts): 
    NM_001207025.2  NM_001207026.1  NM_001247994.1  NM_002698.4  

    Unigene Cluster for POU2F2:

    POU class 2 homeobox 2
    Hs.147381  [show with all ESTs]
    Unigene Representative Sequence: NM_001207025
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000389341(uc002osn.3 uc002osq.3) ENST00000533720 ENST00000560804
    ENST00000526816 ENST00000529067 ENST00000534559 ENST00000533548 ENST00000560558
    ENST00000560398 ENST00000529952(uc002osr.2) ENST00000598842 ENST00000528894
    ENST00000526831 ENST00000530982 ENST00000531773 ENST00000524801 ENST00000532176
    ENST00000558596
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate POU2F2 (see all 92):
    hsa-miR-218-1* hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3148 hsa-miR-3612 hsa-miR-3622a-5p hsa-miR-4289 hsa-miR-663
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    GenScript: all cDNA clones in your preferred vector: POU2F2 (NM_002698)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat POU2F2
      QuantiFast Probe-based Assays in human, mouse, rat POU2F2

    Additional mRNA sequence: 

    AL833648.1 BC006101.1 BT007438.1 M22596.1 M36542.1 M36653.1 M36718.1 M36772.1 
    X13809.1 X13810.1 X53468.1 X53469.1 

    16 DOTS entries:

    DT.100785009  DT.99990511  DT.95069801  DT.100785010  DT.121453175  DT.91700060  DT.413141  DT.100785013 
    DT.413142  DT.413561  DT.65286027  DT.86836027  DT.91741185  DT.95069804  DT.97762188  DT.97775242 

    Selected AceView cDNA sequences (see all 219):

    BU428722 AA400730 M36718 BE465551 AI553728 AA832036 AA805083 AI208828 
    CF137658 CR604513 AA829950 BX100387 AI364649 AU186044 AA749285 AW166309 
    AA805157 BU430118 AA894446 CR594168 AA731643 BM810914 AW135115 AA011627 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for POU2F2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                                      -           -     -     -                 -     -                                                     -           -   
    SP2:                                      -           -     -     -                 -                                                                           
    SP3:                                      -           -                             -                                                                           
    SP4:                                      -           -     -     -                                                                                             
    SP5:                                                        -     -                 -                                                                           

    ExUns: 19
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for POU2F2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    POU2F2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGAGATGA
    POU2F2 Expression
    About this image


    POU2F2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
    POU2F2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POU2F2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.147381

    UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086
    Tissue specificity: Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the
    immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147

        Pathway & Disease-focused RT2 Profiler PCR Arrays including POU2F2: 
              T Helper Cell Differentiation in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat POU2F2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for POU2F2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou2f21 , 5 POU domain, class 2, transcription factor 21, 5 94.6(n)1
    98.45(a)1
      7 (13.73 cM)5
    189871  NM_001163554.11  NP_001157026.11 
     250911145 
    lizard
    (Anolis carolinensis)
    Reptilia POU2F26
    POU class 2 homeobox 2
    47(a)
    1 ↔ 1
    GL343909.1(90878-109230)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pou2f21 POU class 2 homeobox 2 66.74(n)
    71.62(a)
      100497329  XM_002936399.2  XP_002936445.2 
    zebrafish
    (Danio rerio)
    Actinopterygii pou2f2a1 POU domain, class 2, transcription factor 2a 65.42(n)
    68.3(a)
      557055  XM_005173510.1  XP_005173567.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nub3 neuroblast determination transcription
    factor
    74(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-63 Homeobox domain, Pou domain -
    N-terminal to homeobox more
    55(a)   I(8506480-8510320)   --


    ENSEMBL Gene Tree for POU2F2 (if available)
    TreeFam Gene Tree for POU2F2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POU2F2 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F12  POU3F42  POU1F12  POU3F32  
    POU4F32  POU3F22  POU5F1B2  POU4F12  POU2F12  POU6F12  POU5F12  
    14 SIMAP similar genes for POU2F2 using alignment to 12 protein entries:     PO2F2_HUMAN (see all proteins):
    OCT-2    OCT6    POU2F3    POU1F1    POU6F1    POU2F1
    POU5F1P1    POU5F1P4    POU3F1    POU5F1    POU5F1B    POU4F3
    POU3F2    POU3F4

    Find genes that share paralogs with POU2F2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POU2F2 (see all 728)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs129730441,2
    A--42597161(+) tatatA/Tttttt 4 -- int10--------
    rs1906209721,2
    --42779628(+) TAATTG/TTTTTT 3 -- ds50010--------
    rs2018640101,2
    C--42779640(+) TTTTG-/TTTTTT 3 -- ds50010--------
    rs1399787441,2
    C--42779656(+) TTTTTA/GGACAA 3 -- ds50010--------
    rs124602721,2
    H--42779706(+) attacA/Ggttca 3 -- ds50010--------
    rs1418233071,2
    --42780197(+) TCAGAC/TGGAAC 3 -- ut310--------
    rs129921,2
    C--42780230(+) AGGATG/TGAGGA 3 -- ut313Minor allele frequency- T:0.00MN NA 188
    rs37606421,2
    C,F,H--42780353(+) GGTGGT/CGAAAG 3 -- ut314Minor allele frequency- C:0.01EA NS NA 172
    rs1818623301,2
    --42780560(+) CTCTAC/TGAGTT 3 -- ut310--------
    rs2001275491,2
    C--42780569(+) TTGCC-/GAGAGAG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for POU2F2 (42590263 - 42700737 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for POU2F2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2496CNV Insertion18451855
    nsv520239CNV Loss19592680
    nsv911782CNV Loss21882294
    nsv911783CNV Loss21882294
    nsv522854CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POU2F2
    DNA2.0 Custom Variant and Variant Library Synthesis for POU2F2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164176    OMIM disorders: --

    1 disease for POU2F2:    
    About MalaCards
    nodular lymphocyte predominant hodgkin lymphoma


    Find genes that share disorders with POU2F2           About GenesLikeMe

    9 Novoseek inferred disease relationships for POU2F2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    latent infection 54.1 3 8396817 (1), 8139923 (1), 1654947 (1)
    lymphoma b-cell 52.6 3 11904338 (1), 16778825 (1)
    herpes simplex 45 3 8129727 (1), 8645173 (1), 7733899 (1)
    lymphoma 41.4 17 11904338 (2), 16186795 (2), 11591767 (2), 7600290 (1) (see all 8)
    plasmacytoma 21.7 2 11591767 (2)
    hodgkin disease 19.3 2 14608905 (2)
    myeloma 14.5 4 7600290 (2), 2107075 (1), 9598983 (1)
    lymphoma non-hodgkins 0.603 2 11904338 (1), 14608905 (1)
    tumors 0 2 1620122 (1), 19504395 (1)

    Genetic Association Database (GAD): POU2F2
    Human Genome Epidemiology (HuGE) Navigator: POU2F2 (5 documents)

    Export disorders for POU2F2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POU2F2 gene, integrated from 10 sources (see all 174) (see top 10):
    (articles sorted by number of sources associating them with POU2F2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Short introns interrupting the Oct-2 POU domain may prevent recombination between POU family genes without interfering with potential POU domain 'shuffling' in evolution. (PubMed id 7888080)1, 2, 9 Matsuo K....Schaffner W. (Biol. Chem. Hoppe-Seyler 1994)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity. (PubMed id 19625999)1, 4 Filipski K.K....Sparreboom A. (Clin. Pharmacol. Ther. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter. (PubMed id 10480874)1, 2 Prefontaine G.G....Hache R.J.G. (J. Biol. Chem. 1999)
    6. Solution structure of a POU-specific homeodomain: 3D-NMR studies of human B-cell transcription factor Oct-2. (PubMed id 7914745)1, 2 Sivaraja M.... Weiss M.A. (Biochemistry 1994)
    7. Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells. (PubMed id 2328728)1, 2 Muller-Immergluck M.M.... Matthias P. (EMBO J. 1990)
    8. A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. (PubMed id 2904653)1, 2 Mueller M.M.... Matthias P. (Nature 1988)
    9. A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein. (PubMed id 2904654)1, 2 Scheidereit C.... Roder R.G. (Nature 1988)
    10. A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain. (PubMed id 2901913)1, 2 Ko H.-S.... Staudt L.M. (Cell 1988)
    11. The B-cell-specific Oct-2 protein contains POU box- and homeo box- type domains. (PubMed id 3265124)1, 2 Clerc R.G.... Sharp P.A. (Genes Dev. 1988)
    12. Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression. (PubMed id 16186795)1, 9 Heckman C.A....Boxer L.M. (Oncogene 2006)
    13. Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter. (PubMed id 1739980)2, 9 Tanaka M.... Herr W. (Cell 1992)
    14. A high throughput embryonic stem cell screen identifies Oct-2 as a bifunctional regulator of neuronal differentiation. (PubMed id 19270158)1, 9 Theodorou E....Snyder M. (amp 2009)
    15. DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE. (PubMed id 16103132)1, 9 Malin S....Pettersson S. (Nucleic Acids Res. 2005)
    16. Human Oct-1L isoform has tissue-specific expression pattern similar to Oct-2. (PubMed id 12663137)1, 9 Luchina N.N.... Pankratova E.V. (Immunol. Lett. 2003)
    17. NF-kappa B and Oct-2 synergize to activate the human 3' Igh hs4 enhancer in B cells. (PubMed id 14707079)1, 9 Sepulveda M.A....Birshtein B.K. (J. Immunol. 2004)
    18. Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells. (PubMed id 11841448)1, 9 Nagy M.... Matthes T. (Br. J. Haematol. 2002)
    19. Critical role for the Oct-2/OCA-B partnership in Ig-secreting cells. (PubMed id 14662861)1, 9 Salas M. and Eckhardt L.A. (J. Immunol. 2003)
    20. The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat. (PubMed id 9078256)1, 9 Liu Y.Z. and Latchman D.S. (Biochem. J. 1997)
    21. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    22. Immunohistochemical expression of Mum-1, Oct-2 and Bcl-6 in systemic anaplastic large cell lymphomas. (PubMed id 22158496)1 Saglam A. and Uner A.H. (Tumori 2011)
    23. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    24. B-cell transcription factors Pax-5, Oct-2, BOB.1, Bcl-6, and MUM1 are useful markers for the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma. (PubMed id 21424034)1 Herbeck R....IoniALA8 H. (Rom J Morphol Embryol 2011)
    25. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    26. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    27. Functional characterization of gefitinib uptake in non-small cell lung cancer cell lines. (PubMed id 20363215)1 Galetti M....Petronini P.G. (Biochem. Pharmacol. 2010)
    28. OCT-2 expression and OCT-2/BOB.1 co-expression predict prognosis in patients with newly diagnosed acute myeloid leukemia. (PubMed id 20141429)1 Advani A.S....Hsi E. (amp 2010)
    29. Involvement of the organic cation transporters in histamine uptake into human vascular endothelial cells. (PubMed id 19271143)1 Cerne K. and Krzan M. (Inflamm. Res. 2009)
    30. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    31. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. (PubMed id 19536068)1 Tzvetkov M.V....BrockmAPller J. (Clin. Pharmacol. Ther. 2009)
    32. Functional long-range interactions of the IgH 3' enhancers with the bcl-2 promoter region in t(14;18) lymphoma cells. (PubMed id 18695675)1 Duan H....Boxer L.M. (Oncogene 2008)
    33. Production of specific mRNA transcripts, usage of an alternate promoter, and octamer-binding transcription factors influence the surface expression levels of the HIV coreceptor CCR5 on primary T cells. (PubMed id 17442950)1 Mummidi S....Ahuja S.K. (J. Immunol. 2007)
    34. Alterations of loci encoding PU.1, BOB1, and OCT2 transcription regulators do not correlate with their suppressed expression in Hodgkin lymphoma. (PubMed id 15796964)1 Cavazzini F....Wlodarska I. (Cancer Genet. Cytogenet. 2005)
    35. Functional interaction of Oct transcription factors with the family of repeats in Epstein-Barr virus oriP. (PubMed id 15831936)1 Almqvist J....Ernberg I. (J. Gen. Virol. 2005)
    36. S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. (PubMed id 12887926)1 Zheng L.... Luo Y. (Cell 2003)
    37. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    38. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase the binding activity and nuclear level of Oct-1 in mononuclear cells. (PubMed id 12144930)1 Ortego M....Egido J. (Eur. J. Pharmacol. 2002)
    39. Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping. (PubMed id 11583619)1 RemAcnyi A....Wilmanns M. (Mol. Cell 2001)
    40. The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase. (PubMed id 11279128)1 Schild-Poulter C....HachAc R.J. (J. Biol. Chem. 2001)
    41. Functional interaction between Oct-1 and retinoid X receptor. (PubMed id 10383413)1 Kakizawa T....Hashizume K. (J. Biol. Chem. 1999)
    42. Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding. (PubMed id 10490647)1 Wang J.M....HachAc R.J. (Mol. Cell. Biol. 1999)
    43. High mobility group I/Y protein functions as a specific cofactor for Oct-2A: mapping of interaction domains. (PubMed id 9823775)1 Abdulkadir S.A....Ono S.J. (J. Leukoc. Biol. 1998)
    44. The different alternatively spliced isoforms of the Oct-2 transcription factor repress the involucrin promoter in a cell type-specific manner. (PubMed id 9870616)1 Chapman C.M. and Latchman D.S. (Mol. Biol. Rep. 1998)
    45. Recruitment of octamer transcription factors to DNA by glucocorticoid receptor. (PubMed id 9584182)1 PrAcfontaine G.G....HachAc R.J. (Mol. Cell. Biol. 1998)
    46. Coactivator OBF-1 makes selective contacts with both the POU-specific domain and the POU homeodomain and acts as a molecular clamp on DNA. (PubMed id 9819426)1 Sauter P. and Matthias P. (Mol. Cell. Biol. 1998)
    47. Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation. (PubMed id 9242494)1 Andersen B....Rosenfeld M.G. (amp 1997)
    48. Identification of target genes of the lymphoid-specific transcription factor Oct2. (PubMed id 9442393)1 Pfisterer P....Wirth T. (Immunobiology 1997)
    49. The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors. (PubMed id 9368058)1 Inamoto S....Roeder R.G. (J. Biol. Chem. 1997)
    50. Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor. (PubMed id 8902060)1 Liu Y.Z....Latchman D.S. (AIDS 1996)
    51. High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors. (PubMed id 7720710)1 Zwilling S....Wirth T. (EMBO J. 1995)
    52. The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP. (PubMed id 8202368)1 Zwilling S....Wirth T. (Nucleic Acids Res. 1994)
    53. Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules. (PubMed id 8156594)1 Klemm J.D.... Pabo C.O. (Cell 1994)
    54. Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA). (PubMed id 3072196)2 Schreiber E.... Schaffner W. (EMBO J. 1988)
    55. Oct-2 facilitates functional preinitiation complex assembly and is continuously required at the promoter for multiple rounds of transcription. (PubMed id 8428575)9 Arnosti D.N....Schaffner W. (EMBO J. 1993)
    56. Induction of the POU domain transcription factor Oct-2 during T-cell activation by cognate antigen. (PubMed id 1620122)9 Kang S.M....Staudt L.M. (Mol. Cell. Biol. 1992)
    57. Phosphorylation of Oct-2 at sites located in the POU domain induces differential down-regulation of Oct-2 DNA-binding ability. (PubMed id 10727398)9 Pevzner V....Lipp M. (Biochem. J. 2000)
    58. Positive and negative regulation of the composite octamer motif of the interleukin 2 enhancer by AP-1, Oct-2, and retinoic acid receptor. (PubMed id 7931079)9 de Grazia U....Gulino A. (J. Exp. Med. 1994)
    59. Regulation and a possible stage-specific function of Oct-2 during pre-B-cell differentiation. (PubMed id 1922024)9 Miller C.L....Singh H. (Mol. Cell. Biol. 1991)
    60. Oct-2 regulates CD36 gene expression via a consensus octamer, which excludes the co-activator OBF-1. (PubMed id 11937630)9 Shore P....Corcoran L.M. (Nucleic Acids Res. 2002)
    61. Unique function for carboxyl-terminal domain of Oct-2 in Ig-secreting cells. (PubMed id 11591767)9 Sharif M.N....Eckhardt L.A. (J. Immunol. 2001)
    62. Oct-1 [corrected] and Oct-2 DNA-binding site specificity is regulated in vitro by different kinases. (PubMed id 8645173)9 Grenfell S.J....Thomas N.S. (Biochem. J. 1996)
    63. Differentiation of human B-cell malignant lymphomas is independent of the octamer lymphoid specific binding factor (Oct-2). (PubMed id 1937571)9 Kossakowska A.E. and Urbanski S.J. (Immunology 1991)
    64. Constitutively expressed Oct-2 prevents immunoglobulin gene silencing in myeloma x T cell hybrids. (PubMed id 7600290)9 Radomska H.S....Eckhardt L.A. (Immunity 1994)
    65. Oct2 transactivation from a remote enhancer position requires a B-cell-restricted activity. (PubMed id 1620119)9 Annweiler A....Wirth T. (Mol. Cell. Biol. 1992)
    66. Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation. (PubMed id 2302733)9 Tanaka M. and Herr W. (Cell 1990)
    67. The essential role of Oct-2 in LPS-induced expression of iNOS in RAW 264.7 macrophages and its regulation by trichostatin A. (PubMed id 19279235)9 Lu S.C....Chang S.F. (Am. J. Physiol., Cell Physiol. 2009)
    68. Differential transactivation potential of Oct1 and Oct2 is determined by additional B cell-specific activities. (PubMed id 8157005)9 Pfisterer P....Wirth T. (EMBO J. 1994)
    69. Differential positive control by Oct-1 and Oct-2: activation of a transcriptionally silent motif through Oct-1 and VP16 corecruitment. (PubMed id 8422989)9 Cleary M.A....Herr W. (amp 1993)
    70. Role of defective Oct-2 and OCA-B expression in immunoglobulin production and Kaposi's sarcoma-associated herpesvirus lytic reactivation in primary effusion lymphoma. (PubMed id 19224997)9 Di Bartolo D.L....Cesarman E. (J. Virol. 2009)
    71. Analysis of octamer-binding transcription factors Oct2 and Oct1 and their coactivator BOB.1/OBF.1 in lymphomas. (PubMed id 11904338)9 SA!ez A.I....Piris M.A. (Mod. Pathol. 2002)
    72. Optimal Oct-2 affinity for an extended DNA site and the effect of GST fusion on site preference. (PubMed id 11368023)9 Rhee J.M....Turner E.E. (Arch. Biochem. Biophys. 2001)
    73. Transcription factor NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes. (PubMed id 9360945)9 Bendall H.H....Oltz E.M. (J. Biol. Chem. 1997)
    74. Differential regulation of genes encoding synaptic proteins by the Oct-2 transcription factor. (PubMed id 9427500)9 Deans Z.C....Latchman D.S. (Brain Res. Mol. Brain Res. 1997)
    75. The Oct-2 glutamine-rich and proline-rich activation domains can synergize with each other or duplicates of themselves to activate transcription. (PubMed id 8065338)9 Tanaka M....Herr W. (Mol. Cell. Biol. 1994)
    76. The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2. (PubMed id 2204815)9 Kamps M.P....Baltimore D. (Mol. Cell. Biol. 1990)
    77. Oct-2 DNA binding transcription factor: functional consequences of phosphorylation and glycosylation. (PubMed id 16431844)9 Ahmad I....Nasir-ud-Din . (Nucleic Acids Res. 2006)
    78. Overexpression of octamer transcription factors 1 or 2 alone has no effect on HIV-1 transcription in primary human CD4 T cells. (PubMed id 15051391)9 Zhang M....Cron R.Q. (Virology 2004)
    79. Glutamate regulates Oct-2 DNA-binding activity through alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors in cultured chick Bergmann glia cells. (PubMed id 14756804)9 MAcndez J.A....Ortega A. (J. Neurochem. 2004)
    80. The B-cell transcription factors BSAP, Oct-2, and BOB.1 and the pan-B-cell markers CD20, CD22, and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. (PubMed id 14608905)9 Browne P....Chan J.A. (Am. J. Clin. Pathol. 2003)
    81. The Oct-2 POU domain gene in the neuroendocrine brain: a transcriptional regulator of mammalian puberty. (PubMed id 10433239)9 Ojeda S.R....Ma Y.J. (Endocrinology 1999)
    82. An octamer element functions as a regulatory element in the differentiation-responsive CD11c integrin gene promoter: OCT-2 inducibility during myelomonocytic differentiation. (PubMed id 9190935)9 LA^pez-RodrA-guez C....Corbi A.L. (J. Immunol. 1997)
    83. Direct evidence that the POU family transcription factor Oct-2 represses the cellular tyrosine hydroxylase gene in neuronal cells. (PubMed id 8672399)9 Deans Z....Latchman D.S. (J. Mol. Neurosci. 1995)
    84. Cell type- and stage-specific expression of the CD20/B1 antigen correlates with the activity of a diverged octamer DNA motif present in its promoter. (PubMed id 7680653)9 ThAcvenin C....Kehrl J.H. (J. Biol. Chem. 1993)
    85. Identification of sites for distinct DNA binding proteins including Oct-1 and Oct-2 in the Cr2 gene. (PubMed id 1534100)9 Christensen S.M....Weis J.H. (J. Immunol. 1992)
    86. A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain. (PubMed id 1358756)9 Lai J.S....Herr W. (amp 1992)
    87. Extinction of an immunoglobulin kappa promoter in cell hybrids is mediated by the octamer motif and correlates with suppression of Oct-2 expression. (PubMed id 2110507)9 Junker S....Matthias P. (Cell 1990)
    88. Primary diffuse large B-cell lymphoma of the breast. (PubMed id 17690512)9 Kuroda H....Itoyama S. (Breast Cancer 2007)
    89. CD86 and beta2-adrenergic receptor signaling pathways, respectively, increase Oct-2 and OCA-B Expression and binding to the 3'-IgH enhancer in B cells. (PubMed id 15024018)9 Podojil J.R....Sanders V.M. (J. Biol. Chem. 2004)
    90. The human involucrin gene is transcriptionally repressed through a tissue-specific silencer element recognized by Oct-2. (PubMed id 15120610)9 Azuara-Liceaga E....LA^pez-Bayghen E. (Biochem. Biophys. Res. Commun. 2004)
    91. Reconstitution of transcriptional activation domains by reiteration of short peptide segments reveals the modular organization of a glutamine-rich activation domain. (PubMed id 8065339)9 Tanaka M. and Herr W. (Mol. Cell. Biol. 1994)
    92. Mouse Oct-1 contains a composite homeodomain of human Oct-1 and Oct-2. (PubMed id 8441632)9 Suzuki N....SchAPler H.R. (Nucleic Acids Res. 1993)
    93. Transforming growth factor-beta suppresses human B lymphocyte Ig production by inhibiting synthesis and the switch from the membrane form to the secreted form of Ig mRNA. (PubMed id 1903417)9 Kehrl J.H....Fauci A.S. (J. Immunol. 1991)
    94. The B-cell and neuronal forms of the octamer-binding protein Oct-2 differ in DNA-binding specificity and functional activity. (PubMed id 2072899)9 Dent C.L....Latchman D.S. (Mol. Cell. Biol. 1991)
    95. Activation of octamer-containing promoters by either octamer-binding transcription factor 1 (OTF-1) or OTF-2 and requirement of an additional B-cell-specific component for optimal transcription of immunoglobulin promoters. (PubMed id 2123291)9 Pierani A....Roeder R.G. (Mol. Cell. Biol. 1990)
    96. BOB.1 of the channel catfish, Ictalurus punctatus: not a transcriptional coactivator? (PubMed id 19041136)9 Richard M.L....Warr G.W. (Mol. Immunol. 2009)
    97. Epstein-Barr virus latency switch in human B-cells: a physico-chemical model. (PubMed id 17764547)9 Werner M....Aurell E. (BMC Syst Biol 2007)
    98. Characterization of an Oct1 orthologue in the channel catfish, Ictalurus punctatus: a negative regulator of immunoglobulin gene transcription? (PubMed id 17266766)9 Lennard M.L....Warr G.W. (BMC Mol. Biol. 2007)
    99. Glutamate-induced octamer DNA binding and transcriptional control in cultured radial glia cells. (PubMed id 16787415)9 LA^pez-Bayghen E....Ortega A. (J. Neurochem. 2006)
    100. Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma. (PubMed id 16778825)9 Hoefnagel J.J....Vermeer M.H. (Mod. Pathol. 2006)
    101. Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator OBF-1. (PubMed id 8657574)9 Schubart D.B....Matthias P. (Nucleic Acids Res. 1996)
    102. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. (PubMed id 7623806)9 Luo Y. and Roeder R.G. (Mol. Cell. Biol. 1995)
    103. The C-terminus of the B cell activator Oct-2 functions as an activation domain in yeast. (PubMed id 7811293)9 Mead J....Ludmerer S.W. (Biochem. Biophys. Res. Commun. 1994)
    104. The Oct-2 transcription factor represses tyrosine hydroxylase expression via a heptamer TAATGARAT-like motif in the gene promoter. (PubMed id 7908738)9 Dawson S.J....Latchman D.S. (Nucleic Acids Res. 1994)
    105. Alternative splicing of the Oct-2 transcription factor RNA is differentially regulated in neuronal cells and B cells and results in protein isoforms with opposite effects on the activity of octamer/TAATGARAT-containing promoters. (PubMed id 1281152)9 Lillycrop K.A. and Latchman D.S. (J. Biol. Chem. 1992)
    106. Oct-1 and Oct-2 potentiate functional interactions of a transcription factor with the proximal sequence element of small nuclear RNA genes. (PubMed id 1535687)9 Murphy S....Roeder R.G. (Mol. Cell. Biol. 1992)
    107. Interferon-alpha treatment of Daudi cells down-regulates the octamer binding transcription/DNA replication factors Oct-1 and Oct-2. (PubMed id 1939139)9 Dent C.L....Thomas N.S. (J. Biol. Chem. 1991)
    108. The octamer-binding protein Oct-2 represses HSV immediate-early genes in cell lines derived from latently infectable sensory neurons. (PubMed id 1654947)9 Lillycrop K.A....Latchman D.S. (Neuron 1991)
    109. Identification of a novel factor that interacts with an immunoglobulin heavy-chain promoter and stimulates transcription in conjunction with the lymphoid cell-specific factor OTF2. (PubMed id 2109187)9 Yoza B.K. and Roeder R.G. (Mol. Cell. Biol. 1990)
    110. Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution. (PubMed id 1967834)9 Petryniak B....Thompson C.B. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    111. Extinction of Ig genes expression in myeloma x fibroblast somatic cell hybrids is accompanied by repression of the oct-2 gene encoding a B-cell specific transcription factor. (PubMed id 2107075)9 Bergman Y....Laskov R. (EMBO J. 1990)
    112. IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter. (PubMed id 20080768)9 Kis L.L....Klein E. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    113. A unique case of B cell lymphoma relapsing as CD4/CD56 blastic neoplasm. (PubMed id 19504395)9 Au W.Y....Liang R. (amp 2009)
    114. POU2AF1, an amplification target at 11q23, promotes growth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor, TNFRSF17. (PubMed id 17621271)9 Zhao C....Inazawa J. (Oncogene 2008)
    115. Downregulation of internal enhancer activity contributes to abnormally low immunoglobulin expression in the MedB-1 mediastinal B-cell lymphoma cell line. (PubMed id 15682441)9 Ritz O....Wirth T. (J. Pathol. 2005)
    116. Mammalian transcription activation domains of VP16, AP2 and CTF activate transcription in a whole cell extract from Schizosaccharomyces pombe through the SRB/mediator. (PubMed id 15942925)9 Tamayo E....Maldonado E. (Yeast 2005)
    117. Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity. (PubMed id 16061936)9 Goffin V....Van Lint C. (Nucleic Acids Res. 2005)
    118. The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombination. (PubMed id 15252056)9 Kim E.C....Casali P. (J. Biol. Chem. 2004)
    119. OBF1 enhances transcriptional potential of Oct1. (PubMed id 12727885)9 Lins K....SchAPler H.R. (EMBO J. 2003)
    120. Micronodular T-cell/histiocyte-rich large B-cell lymphoma of the spleen: histology, immunophenotype, and differential diagnosis. (PubMed id 12826882)9 Dogan A....Isaacson P.G. (Am. J. Surg. Pathol. 2003)
    121. Regulation of oct-1 gene transcription is different in lymphoid and non-lymphoid cells. (PubMed id 14505828)9 Zhenilo S....Polanovsky O. (Biochimie 2003)
    122. Octamer proteins inhibit IL-4 gene transcription in normal human CD4 T cells. (PubMed id 11781715)9 Cron R.Q....Lewis D.B. (Genes Immun. 2001)
    123. Cutting edge: lack of peripheral B cells and severe agammaglobulinemia in mice simultaneously lacking Bruton's tyrosine kinase and the B cell-specific transcriptional coactivator OBF-1. (PubMed id 10604987)9 Schubart D.B....Matthias P. (J. Immunol. 2000)
    124. Expression of B cell-associated transcription factors in B-cell precursor acute lymphoblastic leukemia cells: association with PU.1 expression, phenotype, and immunogenotype. (PubMed id 10905058)9 Nishii K....Shiku H. (Int. J. Hematol. 2000)
    125. Glia-to-neuron signaling and the neuroendocrine control of female puberty. (PubMed id 11036938)9 Ojeda S.R....Prevot V. (Recent Prog. Horm. Res. 2000)
    126. Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription. (PubMed id 10828057)9 Wolstein O.... Dikstein R. (J. Biol. Chem. 2000)
    127. POU family transcription factors in the nervous system. (PubMed id 10199551)9 Latchman D.S. (J. Cell. Physiol. 1999)
    128. Ionizing radiation stimulates octamer factor DNA binding activity in human carcinoma cells. (PubMed id 10544969)9 Meighan-Mantha R.L....Kasid U. (Mol. Cell. Biochem. 1999)
    129. The activity of the human interleukin-5 conserved lymphokine element 0 is regulated by octamer factors in human cells. (PubMed id 10491186)9 Thomas M.A....Sanderson C.J. (Eur. J. Biochem. 1999)
    130. Examination of POU homeobox gene expression in human breast cancer cells. (PubMed id 10077160)9 Jin T....Goss P.E. (Int. J. Cancer 1999)
    131. POU domain factors in neural development. (PubMed id 10026784)9 Schonemann M.D....Rosenfeld M.G. (Adv. Exp. Med. Biol. 1998)
    132. Oct-1 promoter region contains octamer sites and TAAT motifs recognized by Oct proteins. (PubMed id 9598983)9 Pankratova E.V....Polanovasky O.L. (FEBS Lett. 1998)
    133. Five discrete cis-active domains direct cell type-specific transcription of the vasoactive intestinal peptide (VIP) gene. (PubMed id 9642274)9 Hahm S.H. and Eiden L.E. (J. Biol. Chem. 1998)
    134. Transcription factor effects on chromosome constitution of cell hybrids. (PubMed id 9925930)9 Hines M.D....Eckhardt L.A. (Cytogenet. Cell Genet. 1998)
    135. Extinction of immunoglobulin gene expression in B cells upon fusion with HeLa cells is preceded by rapid nuclear depletion of essential transcription factors and is accompanied by widespread inactivation of genes expressed in a B cell-specific manner. (PubMed id 9372447)9 Junker S....Matthias P. (J. Cell. Sci. 1997)
    136. Cysteine 50 of the POU H domain determines the range of targets recognized by POU proteins. (PubMed id 9207034)9 Stepchenko A.G....Pankratova E.V. (Nucleic Acids Res. 1997)
    137. Cloning and analysis of the promoter region of CCR5, a coreceptor for HIV-1 entry. (PubMed id 9548484)9 Moriuchi H....Fauci A.S. (J. Immunol. 1997)
    138. Characterization of constitutive and inducible transcription factors binding to the P2 NF-AT site in the human interleukin-4 promoter. (PubMed id 9133600)9 Li-Weber M....Krammer P.H. (Gene 1997)
    139. POU-domain factor expression in the trigeminal ganglion and implications for herpes virus regulation. (PubMed id 9116190)9 Turner E.E....Rosenfeld M.G. (Neuroreport 1996)
    140. Prostaglandin E2 inhibits the interleukin-2 promoter activity through down-regulation of the Oct-dependent transcription of the octamer motif. (PubMed id 8964085)9 Felli M.P....Gulino A. (Cell. Immunol. 1996)
    141. Sequence-specific DNA binding of the B-cell-specific coactivator OCA-B. (PubMed id 8769650)9 Cepek K.L....Sharp P.A. (amp 1996)
    142. Induction of the Oct-2 transcription factor in primary sensory neurons during inflammation is nerve growth factor-dependent. (PubMed id 8929970)9 Ensor E....Latchman D.S. (Neurosci. Lett. 1996)
    143. Regulation of human involucrin promoter activity by POU domain proteins. (PubMed id 8663077)9 Welter J.F....Eckert R.L. (J. Biol. Chem. 1996)
    144. Binding and cooperative interactions between two B cell-specific transcriptional coactivators. (PubMed id 8676072)9 Fontes J.D....Peterlin B.M. (J. Exp. Med. 1996)
    145. The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation. (PubMed id 8654375)9 Gstaiger M....Schaffner W. (EMBO J. 1996)
    146. Octamer independent activation of transcription from the kappa immunoglobulin germline promoter. (PubMed id 8972869)9 Prabhu A....Van Ness B. (Nucleic Acids Res. 1996)
    147. Activation and repression of gene expression by POU family transcription factors. (PubMed id 8735273)9 Latchman D.S. (Philos. Trans. R. Soc. Lond., B, Biol. Sci. 1996)
    148. Specific up-regulation of the POU domain transcription factor Oct-2 following axotomy. (PubMed id 8728480)9 Begbie J.L....Latchman D.S. (Neurosci. Lett. 1996)
    149. Structure, organization, and transcription units of the human alpha- platelet-derived growth factor receptor gene, PDGFRA. (PubMed id 8586421)9 Kawagishi J. and Ku T. (Genomics 1995)
    150. Activation of the herpes simplex virus immediate-early gene promoters by neuronally expressed POU family transcription factors. (PubMed id 7733899)9 Lillycrop K.A....Latchman D.S. (Biochem. J. 1995)
    151. Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter. (PubMed id 7642649)9 Nakshatri H....Currie R.A. (J. Biol. Chem. 1995)
    152. Down regulation of the octamer binding protein Oct-1 during growth arrest and differentiation of a neuronal cell line. (PubMed id 7707877)9 Lakin N.D....Latchman D.S. (Brain Res. Mol. Brain Res. 1995)
    153. Involvement of the Ets family factor PU.1 in the activation of immunoglobulin promoters. (PubMed id 7822329)9 Schwarzenbach H....Matthias P. (J. Biol. Chem. 1995)
    154. Cloning, sequencing and expression of two isoforms of the murine oct-1 transcription factor. (PubMed id 7711063)9 Jaffe J....Laskov R. (Biochim. Biophys. Acta 1995)
    155. Role of Oct-2 in immunoglobulin gene silencing. (PubMed id 7486513)9 Radomska H.S....Eckhardt L.A. (Ann. N. Y. Acad. Sci. 1995)
    156. Functional interaction between different isoforms of the Oct-2 transcription factor expressed in neuronal cells. (PubMed id 8129727)9 Lillycrop K.A....Latchman D.S. (Biochem. J. 1994)
    157. A nonconsensus octamer-recognition sequence (TAATGARAT-motif) identifies a novel DNA binding protein in human Merkel cell carcinoma cell lines. (PubMed id 8026890)9 Thomson J.A....Parsons P.G. (Int. J. Cancer 1994)
    158. Inhibition of herpes simplex virus infection by ectopic expression of neuronal splice variants of the Oct-2 transcription factor. (PubMed id 8139923)9 Lillycrop K.A....Latchman D.S. (Nucleic Acids Res. 1994)
    159. Enhanced activation of the human histone H2B promoter by an Oct-1 variant generated by alternative splicing. (PubMed id 8227066)9 Das G. and Herr W. (J. Biol. Chem. 1993)
    160. Ras oncogene transformation of human B lymphoblasts is associated with lymphocyte activation and with a block of differentiation. (PubMed id 8423993)9 Sirinian M.I....Nasi S. (Oncogene 1993)
    161. Transactivation of the human papilloma virus 16 octamer motif by the octamer binding protein Oct-2 requires both the N and C terminal activation domains. (PubMed id 8233784)9 Morris P.J....Latchman D.S. (Nucleic Acids Res. 1993)
    162. Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. (PubMed id 8234287)9 Bhargava A.K.... Weissman S.M. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    163. Gene transcription in differentiating immature T cell receptor(neg) thymocytes resembles antigen-activated mature T cells. (PubMed id 8376926)9 ZA_A+iga-PflA1cker J.C....Lenardo M.J. (J. Exp. Med. 1993)
    164. The octamer binding protein Oct-2 inhibits transactivation of the herpes simplex virus immediate-early genes by the virion protein Vmw65. (PubMed id 8396817)9 Lillycrop K.A....Latchman D.S. (Virology 1993)
    165. Conserved cysteine residues of Oct-2 POU domain confer sensitivity to oxidation but are dispensable for sequence-specific DNA binding. (PubMed id 8504164)9 Rigoni P....Arnosti D.N. (Biochim. Biophys. Acta 1993)
    166. A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells. (PubMed id 1383937)9 Lillycrop K.A....Latchman D.S. (Nucleic Acids Res. 1992)
    167. Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations. (PubMed id 1495986)9 Lai J.S. and Herr W. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    168. Okadaic acid is a potent inducer of AP-1, NF-kappa B, and tumor necrosis factor-alpha in human B lymphocytes. (PubMed id 1520341)9 Rieckmann P....Kehrl J.H. (Biochem. Biophys. Res. Commun. 1992)
    169. Characterization of two Drosophila POU domain genes, related to oct-1 and oct-2, and the regulation of their expression patterns. (PubMed id 1685891)9 Lloyd A. and Sakonju S. (Mech. Dev. 1991)
    170. Transcription factor requirements for U2 snRNA-encoding gene activation in B lymphoid cells. (PubMed id 1765275)9 Janson L. and Pettersson U. (Gene 1991)
    171. Promoters with the octamer DNA motif (ATGCAAAT) can be ubiquitous or cell type-specific depending on binding affinity of the octamer site and Oct-factor concentration. (PubMed id 2014164)9 Kemler I....Schaffner W. (Nucleic Acids Res. 1991)
    172. Octamer-binding proteins in diverse hemopoietic cells. (PubMed id 2106071)9 Cockerill P.N. and Klinken S.P. (Mol. Cell. Biol. 1990)

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