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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

POU2F2 Gene

protein-coding GIFtS: 60
GCID: GC19M042592

POU class 2 homeobox 2

(Previous names: POU domain class 2, transcription factor 2 )
(Previous symbol: OTF2)

Explore 25 diseases affiliated with
POU2F2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
POU Class 2 Homeobox 2¹ ²		OTF-2² ³
OCT2¹ ² ³ ⁵		Oct-2² ³
OTF2¹ ² ³ ⁵		POU Domain Class 2, Transcription Factor 2¹
Lymphoid-Restricted Immunoglobulin Octamer-Binding Protein NF-A2² ³		Homeobox Protein²
Octamer-Binding Protein 2² ³		POU Domain, Class 2, Transcription Factor 2²
Octamer-Binding Transcription Factor 2² ³

External Ids:	HGNC: 9213¹	Entrez Gene: 5452²	Ensembl: ENSG00000028277⁷	OMIM: 164176⁵	UniProtKB: P09086³

Export aliases for POU2F2 gene to outside databases

Previous GC identifers: GC19M043234 GC19M042986 GC19M047271 GC19M047286 GC19M039023

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POU2F2:

The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded

protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene

promoters. Several transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,

Oct 2011)

UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086

Function: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription

in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription

transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the POU2F2 gene promoter:
NRSF form 1 NRSF form 2 Evi-1 E47 HNF-4alpha1 PPAR-gamma1 PPAR-gamma2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POU2F2 promoter sequence

Search SABiosciences Chromatin IP Primers for POU2F2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU2F2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

POU2F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU2F2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M042592: view genomic region (about GC identifiers)

Start:	42,592,650 bp from pter	End:	42,700,737 bp from pter
Size:	108,088 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086 (See protein sequence)

Recommended Name: POU domain, class 2, transcription factor 2

Size: 479 amino acids; 51209 Da

Subunit: Interacts with NR3C1, AR and PGR

Subcellular location: Cytoplasm (By similarity). Nucleus

Sequence caution: Sequence=CAA32039.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for POU2F2:

1HDP (3D)

Secondary accessions: Q16648 Q7M4M8 Q9BRS4

Alternative splicing: 5 isoforms: P09086-1 P09086-2 P09086-3 P09086-4 P09086-5 (Incomplete sequence)

Explore the universe of human proteins at neXtProt for POU2F2: NX_P09086

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P09086

POU2F2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001193954.1 NP_001193955.1 NP_001234923.1 NP_002689.1

ENSEMBL proteins:

ENSP00000373992 ENSP00000437221 ENSP00000452930 ENSP00000431603 ENSP00000437224

ENSP00000436100 ENSP00000453995 ENSP00000454179 ENSP00000453255 ENSP00000436988

ENSP00000454056 ENSP00000431679 ENSP00000453164 ENSP00000453794 ENSP00000339369

ENSP00000292077

Human Recombinant Protein Products for POU2F2:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	9242494
GO:0005737	cytoplasm	IEA	--

POU2F2 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

POU2F2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR010982 Lambda_DNA-bd_dom

IPR000972 TF_octamer

IPR013847 POU

IPR000327 POU_specific

IPR017970 Homeobox_CS

Graphical View of Domain Structure for InterPro Entry P09086

ProtoNet protein and cluster: P09086

3 Blocks protein families:

IPB000327 POU domain

IPB000972 Octamer-binding transcription factor signature

IPB013847 POU

UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086

Similarity: Belongs to the POU transcription factor family. Class-2 subfamily

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 1 POU-specific domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PO2F2_HUMAN, P09086

Function: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription

in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription

transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter

Genatlas biochemistry entry for POU2F2:

POU domain,class 2,transcription factor 2,expressed in the immune system,also involved in the control of the forebrain

development and the cell-cell signaling process underlying the hypothalamic regulation of female puberty

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0019904	protein domain specific binding	IEA	--
GO:0043565	sequence-specific DNA binding	IDA	9242494

POU2F2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for POU2F2:

Synthetic lethal with Ras

8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pou2f2):

behavior/neurological	cellular	growth/size	hematopoietic system	homeostasis/metabolism
immune system	mortality/aging	respiratory system

POU2F2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for POU2F2: Pou2f2^tm1Bal Pou2f2^tm1Lmc

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for POU2F2

		10/229 SABiosciences Target genes for POU2F2 (see all 229):
		ACADM ADCY3 ADH1C AGBL1 AMIGO3 ANKRD39 AOAH AP2A2 AP3S1 AQP7P1

miRNA Products:		miRTarBase miRNAs that target POU2F2: hsa-mir-9 (MIRT000639)

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		8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate POU2F2 (see all 92):
		hsa-miR-218-1* hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3148 hsa-miR-3612 hsa-miR-3622a-5p hsa-miR-4289 hsa-miR-663

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

Development Glucocorticoid receptor signaling

0.27

Development_Glucocorticoid receptor signaling

0.27

SIDS Susceptibility Pathways

SIDS Susceptibility Pathways

1.00

B cell receptor signaling pathway

BCR signaling pathway

0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for POU2F2

Development Glucocorticoid receptor signaling

1 GeneGo (Thomson Reuters) Pathway for POU2F2

Development Glucocorticoid receptor signaling

2 BioSystems Pathways for POU2F2

	SIDS Susceptibility Pathways
	BCR signaling pathway

POU2F2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for POU2F2

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/17 Interacting proteins for POU2F2 (P09086³ ENSP00000373992⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MNAT1	P51948³, ENSP00000261245⁴	I2D: score=3 STRING: ENSP00000261245
NR3C1	P04150³, ENSP00000231509⁴	I2D: score=3 STRING: ENSP00000231509
XRCC6	P12956³, ENSP00000352257⁴	I2D: score=3 STRING: ENSP00000352257
TBP	P20226³, ENSP00000230354⁴	I2D: score=2 STRING: ENSP00000230354
AR	P10275³, ENSP00000363822⁴	I2D: score=1 STRING: ENSP00000363822

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002335	mature B cell differentiation	IEA	--
GO:0002380	immunoglobulin secretion involved in immune response	IEA	--
GO:0006351	transcription, DNA-dependent	--	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	9442393

POU2F2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

POU2F2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POU2F2
7 Novoseek chemical compound relationships for POU2F2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
okadaic acid	14.8	1	10727398 (1)
oligonucleotide	0	2	8026890 (1), 11368023 (1)
steroid	0	1	10433239 (1)
tyrosine	0	5	8672399 (4)
glutamate	0	8	14756804 (4), 16787415 (1), 1358756 (1)
gnrh	0	1	11036938 (1)
serine	0	1	2302733 (1)

Search CenterWatch for drugs/clinical trials and news about POU2F2 / PO2F2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for POU2F2 gene (4 alternative transcripts):

NM_001207025.2 NM_001207026.1 NM_001247994.1 NM_002698.4

Unigene Cluster for POU2F2:

POU class 2 homeobox 2

Hs.147381 [show with all ESTs]

Unigene Representative Sequence: NM_001207025

20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see top 18):

ENST00000389341(uc002osn.3 uc002osq.3) ENST00000533720 ENST00000560804

ENST00000526816 ENST00000529067 ENST00000534559 ENST00000533548 ENST00000560558

ENST00000560398 ENST00000529952(uc002osr.2) ENST00000528894 ENST00000526831

ENST00000530982 ENST00000531773 ENST00000524801 ENST00000532176 ENST00000526933

ENST00000558596 ENST00000342301 ENST00000292077(uc002osp.3)

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		8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate POU2F2 (see all 92):
		hsa-miR-218-1* hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3148 hsa-miR-3612 hsa-miR-3622a-5p hsa-miR-4289 hsa-miR-663

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Additional cDNA sequence:

AL833648.1 BC006101.1 BT007438.1 M22596.1 M36542.1 M36653.1 M36718.1 M36772.1

X13809.1 X13810.1 X53468.1 X53469.1

16 DOTS entries:

DT.100785009 DT.99990511 DT.95069801 DT.100785010 DT.121453175 DT.91700060 DT.413141 DT.100785013

DT.413142 DT.413561 DT.65286027 DT.86836027 DT.91741185 DT.95069804 DT.97762188 DT.97775242

24/219 AceView cDNA sequences (see all 219):

AA832036 AA417604 CR604513 AW316809 BM810914 AA731643 CR615602 AW135115

BE675200 AA894446 AU186044 AA011627 AA829950 M36718 CF137658 CA307156

AI364649 BU430118 AA805083 AW166309 AI553728 AI300318 AI208828 AA884256

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for POU2F2 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	^	15	^	16	^	17	^	18	^
SP1:													-				-		-		-						-		-																		-				-
SP2:													-				-		-		-						-
SP3:													-				-										-
SP4:													-				-		-		-
SP5:																			-		-						-

ExUns:	19
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for POU2F2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

POU2F2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGAGATGA

About this image

POU2F2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See POU2F2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POU2F2

SOURCE GeneReport for Unigene cluster: Hs.147381

UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086

Tissue specificity: Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing

T-cell line MOLT-4, but not in the T-cell line BW5147

SABiosciences Expression via Pathway-Focused PCR Arrays including POU2F2:

T Helper Cell Differentiation in human mouse rat

Homeobox (HOX) Genes in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU2F2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for POU2F2 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	POU2F2⁶	--	42(a)	1 ↔ 1	GL343909.1(96375-106147)
zebrafish (Danio rerio)	Actinopterygii	LOC100534934¹	POU domain, class 2, transcription factor 2-like	66.98(n) 70.26(a)		100534934 XM_003200146.1 XP_003200194.1
fruit fly (Drosophila melanogaster)	Insecta	nub³	neuroblast determination transcription factor	74(a) (best of 2)		--
worm (Caenorhabditis elegans)	Secernentea	ceh-6³	Homeobox domain, Pou domain - N-terminal to homeobox more	55(a)		I(8506480-8510320) --

ENSEMBL Gene Tree for POU2F2 (if available)
TreeFam Gene Tree for POU2F2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for POU2F2 gene

POU5F2² POU6F2² POU4F2² POU2F3² POU3F4² POU3F1² POU1F1² POU4F3²

POU3F3² POU3F2² POU5F1B² POU2F1² POU4F1² POU5F1² POU6F1²

14 SIMAP similar genes for POU2F2 using alignment to 13 protein entries: PO2F2_HUMAN (see all proteins):

OCT-2 OCT6 POU2F3 POU2F1 POU1F1 POU6F1

POU3F1 POU5F1P4 POU5F1P1 POU5F1B POU4F3 POU3F2

POU3F4 POU5F1

POU2F2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12460272^1,2	H	--	39020907(+)	`attacA/Ggttca`	3	--	ds500¹		0	--	--	--	--
rs12992^1,2	C	--	39021431(+)	`AGGATG/TGAGGA`	3	--	ut3¹		3		MN NA	188
rs3760642^1,2	C,F,H	--	39021554(+)	`GGTGGT/CGAAAG`	3	--	ut3¹		4		EA NS NA	172
rs79731015^1,2	F	--	39022610(+)	`CACACC/ACACCC`	3	--	ut3¹		1		WA	118
rs1152712^1,2	C,F,H	--	39023021(+)	`ACCAGA/CGTGTA`	3	--	ut3¹		11		MN NS NA WA	1546
rs10425402^1,2	C,H	--	39023847(+)	`GCGGAG/AATGCT`	3	--	ut3¹		6		NS EA NA	420
rs10425682^1,2	C,F,H	--	39023991(+)	`GCCCAG/ACCCAA`	3	--	ut3¹		8		NS EA NA	1044
rs201140249^1,2	C	--	39024186(+)	`GGCTGG/TCAGGC`	3	--	ut3¹		0	--	--	--	--
rs73932872^1,2	C	--	39024193(+)	`AGGCCC/GCACCC`	3	--	ut3¹		2		WA	120
rs77074519^1,2		--	39024960(+)	`GAGACA/GTGTCC`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for POU2F2 (42592650 - 42700737 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for POU2F2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POU2F2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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POU2F2 for disorders           About GeneDecksing

OMIM gene information: 164176    OMIM disorders: --

20/25 diseases for POU2F2 (see all 25):    About MalaCards

diffuse large b-cell lymphoma b-cell lymphomas primary effusion lymphoma herpes simplex

plasmacytoma merkel cell carcinoma acute lymphoblastic leukemia lymphoblastic leukemia

acute myeloid leukemia myeloid leukemia kaposi's sarcoma hodgkin's lymphoma

multiple myeloma mediastinitis myeloma papilloma

hermaphroditism conjunctivitis breast lymphoma leukemia

9 Novoseek disease relationships for POU2F2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
latent infection	54.1	3	8396817 (1), 8139923 (1), 1654947 (1)
lymphoma b-cell	52.6	3	11904338 (1), 16778825 (1)
herpes simplex	45	3	8129727 (1), 8645173 (1), 7733899 (1)
lymphoma	41.4	17	11904338 (2), 16186795 (2), 11591767 (2), 7600290 (1) (see all 8)
plasmacytoma	21.7	2	11591767 (2)
hodgkin disease	19.3	2	14608905 (2)
myeloma	14.5	4	7600290 (2), 2107075 (1), 9598983 (1)
lymphoma non-hodgkins	0.603	2	11904338 (1), 14608905 (1)
tumors	0	2	1620122 (1), 19504395 (1)

Human Genome Epidemiology (HuGE) Navigator: POU2F2 (5 documents)

Export disorders for POU2F2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for POU2F2 gene, integrated from 9 sources (see all 172):
(articles sorted by number of sources associating them with POU2F2)

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Short introns interrupting the Oct-2 POU domain may prevent recombination between POU family genes without interfering with potential POU domain 'shuffling' in evolution. (PubMed id 7888080)^{1, 2, 9} Matsuo K....Schaffner W. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter. (PubMed id 10480874)^{1, 2} Prefontaine G.G....Hache R.J.G. (1999)
Solution structure of a POU-specific homeodomain: 3D-NMR studies of human B-cell transcription factor Oct-2. (PubMed id 7914745)^{1, 2} Sivaraja M.... Weiss M.A. (1994)
Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells. (PubMed id 2328728)^{1, 2} Muller-Immergluck M.M.... Matthias P. (1990)
A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. (PubMed id 2904653)^{1, 2} Mueller M.M.... Matthias P. (1988)
A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein. (PubMed id 2904654)^{1, 2} Scheidereit C.... Roder R.G. (1988)
A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain. (PubMed id 2901913)^{1, 2} Ko H.-S.... Staudt L.M. (1988)
The B-cell-specific Oct-2 protein contains POU box- and homeo box- type domains. (PubMed id 3265124)^{1, 2} Clerc R.G.... Sharp P.A. (1988)
Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression. (PubMed id 16186795)^{1, 9} Heckman C.A....Boxer L.M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5452	HGNC: 9213	AceView: POU2F2	Ensembl:ENSG00000028277	euGenes: HUgn5452
ECgene: POU2F2	H-InvDB: POU2F2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for POU2F2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for POU2F2 gene
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Patent Information for POU2F2 gene:
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POU class 2 homeobox 2

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POU2F2 Gene

POU class 2 homeobox 2

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