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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

POU2F2 Gene

protein-coding GIFtS: 60
GCID: GC19M042592

POU Class 2 Homeobox 2

(Previous names: POU domain class 2, transcription factor 2)
(Previous symbol: OTF2)

25 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
POU Class 2 Homeobox 2¹ ²		OTF-2² ³
OTF2¹ ² ³ ⁵		Oct-2² ³
OCT2² ³ ⁵		POU Domain Class 2, Transcription Factor 2¹
Lymphoid-Restricted Immunoglobulin Octamer-Binding Protein NF-A2² ³		Homeobox Protein²
Octamer-Binding Protein 2² ³		POU Domain, Class 2, Transcription Factor 2²
Octamer-Binding Transcription Factor 2² ³

External Ids:	HGNC: 9213¹	Entrez Gene: 5452²	Ensembl: ENSG00000028277⁷	OMIM: 164176⁵	UniProtKB: P09086³

Export aliases for POU2F2 gene to outside databases

Previous GC identifers: GC19M043234 GC19M042986 GC19M047271 GC19M047286 GC19M039023

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POU2F2 Gene:

The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The

encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in

immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this

gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for POU2F2 Gene:

POU2F2 (POU class 2 homeobox 2) is a protein-coding gene. Diseases associated with POU2F2 include breast lymphoma, and primary effusion lymphoma, and among its related super-pathways are Development Glucocorticoid receptor signaling and B cell receptor signaling pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein domain specific binding. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086

Function: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates

transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates

transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NT_011109.16 NC_018930.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the POU2F2 gene promoter:
NRSF form 1 NRSF form 2 Evi-1 E47 HNF-4alpha1 PPAR-gamma1 PPAR-gamma2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POU2F2 promoter sequence

Search SABiosciences Chromatin IP Primers for POU2F2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU2F2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

POU2F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU2F2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M042592: view genomic region (about GC identifiers)

Start:	42,590,263 bp from pter	End:	42,700,737 bp from pter
Size:	110,475 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086 (See protein sequence)

Recommended Name: POU domain, class 2, transcription factor 2

Size: 479 amino acids; 51209 Da

Subunit: Interacts with NR3C1, AR and PGR

Subcellular location: Cytoplasm (By similarity). Nucleus

Sequence caution: Sequence=CAA32039.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for POU2F2:

1HDP (3D)

Secondary accessions: Q16648 Q7M4M8 Q9BRS4

Alternative splicing: 5 isoforms: P09086-1 P09086-2 P09086-3 P09086-4 P09086-5 (Incomplete sequence)

Explore the universe of human proteins at neXtProt for POU2F2: NX_P09086

Explore proteomics data for POU2F2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P09086

POU2F2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (4 alternative transcripts):

NP_001193954.1 NP_001193955.1 NP_001234923.1 NP_002689.1

ENSEMBL proteins:

ENSP00000373992 ENSP00000437221 ENSP00000452930 ENSP00000431603 ENSP00000437224

ENSP00000436100 ENSP00000453995 ENSP00000454179 ENSP00000453255 ENSP00000436988

ENSP00000471890 ENSP00000475664 ENSP00000476062 ENSP00000476240 ENSP00000339369

Human Recombinant Protein Products for POU2F2:

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	Novus Biologicals POU2F2 Protein Novus Biologicals POU2F2 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	9242494
GO:0005737	cytoplasm	IEA	--

POU2F2 for ontologies About GeneDecksing

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Assay Products for POU2F2:

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	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

POU: Homeoboxes / POU class

5/7 InterPro protein domains (see all 7):

IPR010982 Lambda_DNA-bd_dom

IPR000972 TF_octamer

IPR013847 POU

IPR000327 POU_specific

IPR017970 Homeobox_CS

Graphical View of Domain Structure for InterPro Entry P09086

ProtoNet protein and cluster: P09086

3 Blocks protein domains:

IPB000327 POU domain

IPB000972 Octamer-binding transcription factor signature

IPB013847 POU

UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086

Similarity: Belongs to the POU transcription factor family. Class-2 subfamily

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 1 POU-specific domain

POU2F2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PO2F2_HUMAN, P09086

Function: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates

transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates

transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter

Genatlas biochemistry entry for POU2F2:

POU domain,class 2,transcription factor 2,expressed in the immune system,also involved in the control of the

forebrain development and the cell-cell signaling process underlying the hypothalamic regulation of female

puberty

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0019904	protein domain specific binding	IEA	--
GO:0043565	sequence-specific DNA binding	IDA	9242494

POU2F2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for POU2F2:

Synthetic lethal with Ras

8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pou2f2):

behavior/neurological	cellular	growth/size	hematopoietic system	homeostasis/metabolism
immune system	mortality/aging	respiratory system

POU2F2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for POU2F2: Pou2f2^tm1Bal Pou2f2^tm1Lmc

inGenious Targeting Laboratory - Custom generated mouse model solutions for POU2F2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POU2F2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU2F2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU2F2

		10/225 SABiosciences Target genes for POU2F2 (see all 225):
		ACADM ADCY3 ADH1C AGBL1 AMIGO3 ANKRD39 AOAH AP2A2 AP3S1 AQP7P1

miRNA Products:		miRTarBase miRNAs that target POU2F2: hsa-mir-9 (MIRT000639)

		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU2F2
		8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate POU2F2 (see all 92):
		hsa-miR-218-1* hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3148 hsa-miR-3612 hsa-miR-3622a-5p hsa-miR-4289 hsa-miR-663

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for POU2F2
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for POU2F2
		Search LifeMap BioReagents cell lines for POU2F2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for POU2F2 About

See pathways by source

SuperPath

Contained pathways About

Development Glucocorticoid receptor signaling

Development Glucocorticoid receptor signaling

1.00

B cell receptor signaling pathway

BCR signaling pathway

0.42

SIDS Susceptibility Pathways

SIDS Susceptibility Pathways

Pathways by source See SuperPaths
Show all pathways

1 EMD Millipore Pathway for POU2F2

Development Glucocorticoid receptor signaling

1 GeneGo (Thomson Reuters) Pathway for POU2F2

Development Glucocorticoid receptor signaling

2 BioSystems Pathways for POU2F2

	SIDS Susceptibility Pathways
	BCR signaling pathway

POU2F2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for POU2F2

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/17 Interacting proteins for POU2F2 (P09086³ ENSP00000373992⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MNAT1	P51948³, ENSP00000261245⁴	I2D: score=3 STRING: ENSP00000261245
NR3C1	P04150³, ENSP00000231509⁴	I2D: score=3 STRING: ENSP00000231509
XRCC6	P12956³, ENSP00000352257⁴	I2D: score=3 STRING: ENSP00000352257
TBP	P20226³, ENSP00000230354⁴	I2D: score=2 STRING: ENSP00000230354
AR	P10275³, ENSP00000363822⁴	I2D: score=1 STRING: ENSP00000363822

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002335	mature B cell differentiation	IEA	--
GO:0002380	immunoglobulin secretion involved in immune response	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	9442393
GO:0006959	humoral immune response	TAS	9442393

POU2F2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

POU2F2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POU2F2 (PO2F2)

7 Novoseek inferred chemical compound relationships for POU2F2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
okadaic acid	14.8	1	10727398 (1)
oligonucleotide	0	2	8026890 (1), 11368023 (1)
steroid	0	1	10433239 (1)
tyrosine	0	5	8672399 (4)
glutamate	0	8	14756804 (4), 16787415 (1), 1358756 (1)
gnrh	0	1	11036938 (1)
serine	0	1	2302733 (1)

Search CenterWatch for drugs/clinical trials and news about POU2F2 / PO2F2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for POU2F2 gene (4 alternative transcripts):

NM_001207025.2 NM_001207026.1 NM_001247994.1 NM_002698.4

Unigene Cluster for POU2F2:

POU class 2 homeobox 2

Hs.147381 [show with all ESTs]

Unigene Representative Sequence: NM_001207025

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000389341(uc002osn.3 uc002osq.3) ENST00000533720 ENST00000560804

ENST00000526816 ENST00000529067 ENST00000534559 ENST00000533548 ENST00000560558

ENST00000560398 ENST00000529952(uc002osr.2) ENST00000598842 ENST00000528894

ENST00000526831 ENST00000530982 ENST00000531773 ENST00000524801 ENST00000532176

ENST00000558596

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU2F2
		8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate POU2F2 (see all 92):
		hsa-miR-218-1* hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3148 hsa-miR-3612 hsa-miR-3622a-5p hsa-miR-4289 hsa-miR-663

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Additional mRNA sequence:

AL833648.1 BC006101.1 BT007438.1 M22596.1 M36542.1 M36653.1 M36718.1 M36772.1

X13809.1 X13810.1 X53468.1 X53469.1

16 DOTS entries:

DT.100785009 DT.99990511 DT.95069801 DT.100785010 DT.121453175 DT.91700060 DT.413141 DT.100785013

DT.413142 DT.413561 DT.65286027 DT.86836027 DT.91741185 DT.95069804 DT.97762188 DT.97775242

219 AceView cDNA sequences (see top 24):

X13809 AA832036 BC006101 AA884256 AI359226 BM810914 AW135115 CF137658

BM452058 AI364649 BU428722 M36718 AA805083 AA417604 CA307156 M22596

AA400730 BE465551 AA749285 BX100387 AA805157 CR604513 AI208828 AW166309

AA731643 AI364695 AW316809 BU430118 AI300318 CR594168 AA011627 AA894446

AU186044 AA829950 CR615602 BE675200 AI553728 AI241397 BQ069989 BG756240

BX386801 AA744781 BQ185656 AI051681 BX282790 AA948030 AA731213 AW269941

BQ185460 AA372027 X53468 AA251078 AA648269 M36653 BI907587 CK299118

AW402109 BT007438 AI192056 BQ027393 AA732709 AA721210 BM153100 BQ686388

AA814544 AW503080 BX342619 AA027348 AI761000 BG686022 CF136979 AI276232

AA432279 BV199625 AA767331 N49616 BI910933 AA431272 CF136594 BI905873

BI911233 AA814402 AI949453 AA831452 AW337506 AI167252 BX099450 AA251181

BG685678 AA603319 CD251869 BI760102 BM467285 BG230646 AA393715 BE560717

R85276 BF062323 BX367323 BX401595 AA830023 AI082494 BX283460 BF510728

BX385121 AL833648 AI393407 AI128484 AA372286 BQ021340 H24738 BV189909

BI906359 AA805754 AA806050 CF136988 BU430948 M36542 X13810 AW576429

M36772 X53469 AW500355 BE674891 BU934681 AW408689 BU623811 BM807954

AA255847 AA732618 AW499986 BG013933 AA804651 NM_002698 AW505146 BX385120

AW503507 AA810467 BX386800 BG758460 AA579229 AW136536 AW408011 AW963421

CF136724 AA713993 AA805767 AW501434 AW505485 AW406170 AA825272 AI703496

R11531 AI568341 AW504990 AW499994 AI523570 BG106848 AA633405 H24737

BF089205 AI365402 BX367322 AA705030 AW474773 AW505453 T90110 BG013953

AI207155 AA419542 AA741513 AW027117 AW504770 AW967458 BI906611 H42723

AW501449 AW403492 AA768396 T82934 H44829 AA873635 AI439524 AW138561

AW339820 BU588855 AI657122 AA634184 BX342618 BI908331 AW500889 BX401594

H28301 AW795467 AA828351 BG024363 AA744545 H28302 AW403460 AI762108

AA255997 BQ000822 BI912283 AA738210 N46922 T99553 CB995118 BU537113

AI536070 BF509229 H42722 BG119904 AA806968 AI568763 H44840 H26541

R10456 BG118380 AW977811

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for POU2F2 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	^	15	^	16	^	17	^	18	^
SP1:													-				-		-		-						-		-																		-				-
SP2:													-				-		-		-						-
SP3:													-				-										-
SP4:													-				-		-		-
SP5:																			-		-						-

ExUns:	19
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for POU2F2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

POU2F2 expression in normal human tissues (normalized intensities) POU2F2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGGAGATGA

About this image

POU2F2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/7 selected tissues (see all 7) fully expand


Lymph (Hematopoietic System) fully expand to see all 4 entries
lymph node ; non-germinal center cells
LYMPH NODE

Tonsil (Hematopoietic System) fully expand to see all 2 entries
tonsil ; non-germinal center cells

Smooth Muscle (Muscoskeletal System)
Juxtaglomerular Cells Afferent Arteriole

Kidney (Urinary System)
Juxtaglomerular Cells Afferent Arteriole

Ovary (Reproductive System)
oocyte

See POU2F2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POU2F2

SOURCE GeneReport for Unigene cluster: Hs.147381

UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086

Tissue specificity: Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the

immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147

SABiosciences Expression via Pathway-Focused PCR Arrays including POU2F2:

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Homeobox (HOX) Genes in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for POU2F2 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pou2f2^{1 , 5}	POU domain, class 2, transcription factor 2^{1, 5}	94.6(n)¹ 98.45(a)¹		7 (13.73 cM)⁵ 18987¹ NM_001163554.1¹ NP_001157026.1¹ 25091909⁵
lizard (Anolis carolinensis)	Reptilia	POU2F2⁶	Uncharacterized protein	46(a)	1 ↔ 1	GL343909.1(90878-109230)
zebrafish (Danio rerio)	Actinopterygii	LOC100534934¹	POU domain, class 2, transcription factor 2-like	66.98(n) 70.26(a)		100534934 XM_003200146.1 XP_003200194.1
fruit fly (Drosophila melanogaster)	Insecta	nub³	neuroblast determination transcription factor	74(a) (best of 2)		--

ENSEMBL Gene Tree for POU2F2 (if available)
TreeFam Gene Tree for POU2F2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for POU2F2 gene

POU5F2² POU6F2² POU4F2² POU2F3² POU3F1² POU3F4² POU1F1² POU3F3²

POU4F3² POU3F2² POU5F1B² POU4F1² POU2F1² POU6F1² POU5F1²

14 SIMAP similar genes for POU2F2 using alignment to 13 protein entries: PO2F2_HUMAN (see all proteins):

OCT-2 OCT6 POU2F3 POU6F1 POU2F1 POU1F1

POU5F1P4 POU3F1 POU5F1P1 POU5F1B POU4F3 POU3F2

POU5F1 POU3F4

POU2F2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12973044^1,2	A	--	42597161(+)	`tatatA/Tttttt`	4	--	int¹		0	--	--	--	--
rs190620972^1,2		--	42779628(+)	`TAATTG/TTTTTT`	3	--	ds500¹		0	--	--	--	--
rs201864010^1,2	C	--	42779640(+)	`TTTTG-/TTTTTT`	3	--	ds500¹		0	--	--	--	--
rs139978744^1,2	C	--	42779656(+)	`TTTTTA/GGACAA`	3	--	ds500¹		0	--	--	--	--
rs12460272^1,2	H	--	42779706(+)	`attacA/Ggttca`	3	--	ds500¹		0	--	--	--	--
rs141823307^1,2		--	42780197(+)	`TCAGAC/TGGAAC`	3	--	ut3¹		0	--	--	--	--
rs12992^1,2	C	--	42780230(+)	`AGGATG/TGAGGA`	3	--	ut3¹		3		MN NA	188
rs3760642^1,2	C,F,H	--	42780353(+)	`GGTGGT/CGAAAG`	3	--	ut3¹		4		EA NS NA	172
rs181862330^1,2		--	42780560(+)	`CTCTAC/TGAGTT`	3	--	ut3¹		0	--	--	--	--
rs200127549^1,2	C	--	42780569(+)	`TTGCC-/GAGAGAG`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for POU2F2 (42590263 - 42700737 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for POU2F2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv2496	CNV	Insertion	18451855
nsv520239	CNV	Loss	19592680
nsv911782	CNV	Loss	21882294
nsv911783	CNV	Loss	21882294
nsv522854	CNV	Gain	19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 164176 OMIM disorders: --

20/25 diseases for POU2F2 (see all 25): About MalaCards

breast lymphoma primary effusion lymphoma plasmacytoma merkel cell carcinoma

herpes simplex mediastinitis b-cell lymphomas myeloma

diffuse large b-cell lymphoma conjunctivitis papilloma kaposi's sarcoma

anaplastic large cell lymphoma acute lymphoblastic leukemia multiple myeloma acute myeloid leukemia

lymphoblastic leukemia sarcoma hodgkin's lymphoma myeloid leukemia

POU2F2 for disorders About GeneDecksing

9 Novoseek inferred disease relationships for POU2F2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
latent infection	54.1	3	8396817 (1), 8139923 (1), 1654947 (1)
lymphoma b-cell	52.6	3	11904338 (1), 16778825 (1)
herpes simplex	45	3	8129727 (1), 8645173 (1), 7733899 (1)
lymphoma	41.4	17	11904338 (2), 16186795 (2), 11591767 (2), 7600290 (1) (see all 8)
plasmacytoma	21.7	2	11591767 (2)
hodgkin disease	19.3	2	14608905 (2)
myeloma	14.5	4	7600290 (2), 2107075 (1), 9598983 (1)
lymphoma non-hodgkins	0.603	2	11904338 (1), 14608905 (1)
tumors	0	2	1620122 (1), 19504395 (1)

Genetic Association Database (GAD): POU2F2
Human Genome Epidemiology (HuGE) Navigator: POU2F2 (5 documents)

Export disorders for POU2F2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for POU2F2 gene, integrated from 9 sources (see all 174):
(articles sorted by number of sources associating them with POU2F2)

Utopia: connect your pdf to the dynamic
world of online information

Short introns interrupting the Oct-2 POU domain may prevent recombination between POU family genes without interfering with potential POU domain 'shuffling' in evolution. (PubMed id 7888080)^{1, 2, 9} Matsuo K....Schaffner W. (1994)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (2010)
Contribution of organic cation transporter 2 (OCT2) t o cisplatin-induced nephrotoxicity. (PubMed id 19625999)^{1, 4} Filipski K.K....Sparreboom A. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter. (PubMed id 10480874)^{1, 2} Prefontaine G.G....Hache R.J.G. (1999)
Solution structure of a POU-specific homeodomain: 3D-NMR studies of human B-cell transcription factor Oct-2. (PubMed id 7914745)^{1, 2} Sivaraja M.... Weiss M.A. (1994)
Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells. (PubMed id 2328728)^{1, 2} Muller-Immergluck M.M.... Matthias P. (1990)
A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. (PubMed id 2904653)^{1, 2} Mueller M.M.... Matthias P. (1988)
A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein. (PubMed id 2904654)^{1, 2} Scheidereit C.... Roder R.G. (1988)
A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain. (PubMed id 2901913)^{1, 2} Ko H.-S.... Staudt L.M. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5452	HGNC: 9213	AceView: POU2F2	Ensembl:ENSG00000028277	euGenes: HUgn5452
ECgene: POU2F2	H-InvDB: POU2F2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for POU2F2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for POU2F2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for POU2F2 gene:
Search GeneIP for patents involving POU2F2

GeneCards and IP:
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POU Class 2 Homeobox 2

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