Aliases for POU2F2 Gene
Aliases for POU2F2 Gene
External Ids for POU2F2 Gene
- HGNC: 9213
- Entrez Gene: 5452
- Ensembl: ENSG00000028277
- OMIM: 164176
- UniProtKB: P09086
Previous HGNC Symbols for POU2F2 Gene
- OTF2
Previous GeneCards Identifiers for POU2F2 Gene
- GC19M043234
- GC19M042986
- GC19M047271
- GC19M047286
- GC19M042592
- GC19M039023
Summaries for POU2F2 Gene
-
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for POU2F2 Gene
POU2F2 (POU Class 2 Homeobox 2) is a Protein Coding gene. Diseases associated with POU2F2 include Papilloma. Among its related pathways are Gene Expression and SIDS Susceptibility Pathways. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein domain specific binding. An important paralog of this gene is POU6F1.
UniProtKB/Swiss-Prot for POU2F2 Gene
-
Transcription factor that specifically binds to the octamer motif (5-ATTTGCAT-3). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU2F2 Gene
Genomics for POU2F2 Gene
Regulatory Elements for POU2F2 Gene
Enhancers for POU2F2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around POU2F2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the POU2F2 gene promoter:
Regulatory Element Products
Genomic Location for POU2F2 Gene
- Chromosome:
- 19
- Start:
- 42,086,110 bp from pter
- End:
- 42,196,585 bp from pter
- Size:
- 110,476 bases
- Orientation:
- Minus strand
Genomic View for POU2F2 Gene
Genes around POU2F2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
POU2F2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POU2F2 Gene
Proteins for POU2F2 Gene
-
Protein details for POU2F2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09086-PO2F2_HUMAN
- Recommended name:
- POU domain, class 2, transcription factor 2
- Protein Accession:
- P09086
- Q16648
- Q7M4M8
- Q9BRS4
Protein attributes for POU2F2 Gene
- Size:
- 479 amino acids
- Molecular mass:
- 51209 Da
- Quaternary structure:
-
- Interacts with NR3C1, AR and PGR.
- SequenceCaution:
-
- Sequence=CAA32039.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for POU2F2 Gene
Post-translational modifications for POU2F2 Gene
Other Protein References for POU2F2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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-
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Protein Products
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Assay Products
No data available for DME Specific Peptides for POU2F2 Gene
Domains & Families for POU2F2 Gene
Gene Families for POU2F2 Gene
Protein Domains for POU2F2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for POU2F2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P09086UniProtKB/Swiss-Prot:
PO2F2_HUMAN :- Contains 1 homeobox DNA-binding domain.
- Belongs to the POU transcription factor family. Class-2 subfamily.
- Domain:
-
- Contains 1 homeobox DNA-binding domain.
- Contains 1 POU-specific domain.
- Family:
-
- Belongs to the POU transcription factor family. Class-2 subfamily.
Function for POU2F2 Gene
Molecular function for POU2F2 Gene
- GENATLAS Biochemistry:
- POU domain,class 2,transcription factor 2,expressed in the immune system,also involved in the control of the forebrain development and the cell-cell signaling process underlying the hypothalamic regulation of female puberty
- UniProtKB/Swiss-Prot Function:
- Transcription factor that specifically binds to the octamer motif (5-ATTTGCAT-3). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.
Phenotypes for POU2F2 Gene
- MGI mutant phenotypes for POU2F2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for POU2F2:
-
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased shRNA abundance (Z-score > 2)
- Effect on mitosis
- Decreased Salmonella proliferation
- Decreased interferon-beta reporter expression
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CRISPR Products
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-
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miRNA for POU2F2 Gene
- miRTarBase miRNAs that target POU2F2
-
- hsa-mir-9-5p (MIRT000639)
- hsa-mir-4768-5p (MIRT388051)
- hsa-mir-6809-3p (MIRT388055)
- hsa-mir-6833-3p (MIRT388056)
- hsa-mir-1277-5p (MIRT509443)
- hsa-mir-6083 (MIRT509444)
- hsa-mir-190a-3p (MIRT509445)
- hsa-mir-4307 (MIRT509446)
- hsa-mir-5011-5p (MIRT509447)
- hsa-mir-5006-3p (MIRT521790)
- hsa-mir-4755-5p (MIRT521791)
- hsa-mir-211-5p (MIRT521792)
- hsa-mir-204-5p (MIRT521793)
- hsa-mir-623 (MIRT521794)
- hsa-mir-6832-3p (MIRT521795)
- hsa-mir-410-3p (MIRT521796)
- hsa-mir-513c-3p (MIRT521797)
- hsa-mir-513a-3p (MIRT521798)
- hsa-mir-3606-3p (MIRT521799)
- hsa-mir-6755-5p (MIRT614838)
- hsa-mir-6841-5p (MIRT614839)
- hsa-mir-6512-5p (MIRT614840)
- hsa-mir-6768-3p (MIRT614841)
- hsa-mir-6888-3p (MIRT666864)
- hsa-mir-6794-3p (MIRT666865)
- hsa-mir-3120-5p (MIRT666866)
- hsa-mir-1304-3p (MIRT666867)
- hsa-mir-3162-3p (MIRT666868)
- hsa-mir-4639-3p (MIRT666869)
- hsa-mir-510-5p (MIRT666870)
- hsa-mir-10b-5p (MIRT666871)
- hsa-mir-10a-5p (MIRT666872)
- hsa-mir-504-5p (MIRT666873)
- hsa-mir-6839-3p (MIRT720155)
- hsa-mir-659-3p (MIRT720156)
- hsa-mir-29b-2-5p (MIRT720157)
- hsa-mir-4753-3p (MIRT720158)
- hsa-mir-130b-5p (MIRT720159)
Transcription Factor Targets for POU2F2 Gene
Targeted motifs for POU2F2 Gene
HOMER Transcription Factor Regulatory Elements motif POU2F2
- Consensus sequence: ATATGCAAAT Submotif: canonical Cell Type: Bcell GEO ID: GSE21512
miRNA Products
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function and Human Phenotype Ontology for POU2F2 Gene
Localization for POU2F2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for POU2F2 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for POU2F2 Gene
More details on SuperPathways for POU2F2Pathways by source for POU2F2 Gene
2 BioSystems pathways for POU2F2 Gene
2 Reactome pathways for POU2F2 Gene
1 GeneGo (Thomson Reuters) pathway for POU2F2 Gene
Interacting Proteins for POU2F2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002380 | immunoglobulin secretion involved in immune response | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0045893 | positive regulation of transcription, DNA-templated | IEA | -- |
| GO:0048469 | cell maturation | IEA | -- |
Drugs & Compounds for POU2F2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dolutegravir | Approved | Pharma | Enzyme, inhibitor | 128 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for POU2F2 Gene
mRNA/cDNA for POU2F2 Gene
- (10) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (219) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for POU2F2 Gene
- POU class 2 homeobox 2:
- Representative Sequences:
CRISPR Products
-
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-
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miRNA Products
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Inhibitory RNA Products
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Clone Products
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - |
| ExUns: | 19 |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: |
Expression for POU2F2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Juxtaglomerular Cells Afferent Arteriole
-
Smooth Muscle (Muscoskeletal System)
- Juxtaglomerular Cells Afferent Arteriole
mRNA differential expression in normal tissues according to GTEx for POU2F2 Gene
This gene is overexpressed in Whole Blood (x7.5) and Spleen (x5.3).
This gene is overexpressed in Peripheral blood mononuclear cells (30.6), Blymphocyte (21.6), and Monocytes (16.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POU2F2 Gene
SOURCE GeneReport for Unigene cluster for POU2F2 Gene Hs.147381
mRNA Expression by UniProt/SwissProt for POU2F2 Gene
P09086-PO2F2_HUMAN
Tissue specificity:
Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147.
Primer Products
-
OriGene qPCR primer pairs for POU2F2
Orthologs for POU2F2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | POU2F2 35 |
|
||
| POU2F2 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Pou2f2 35 |
|
||
| Pou2f2 16 |
|
||||
| Pou2f2 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | POU2F2 35 |
|
||
| POU2F2 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Pou2f2 35 |
|
||
| cow (Bos Taurus) |
Mammalia | POU2F2 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | POU2F2 36 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | POU2F2 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pou2f2 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pou2f2a 35 |
|
||
| pou2f2a 36 |
|
OneToMany | |||
| pou2f2b 36 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | nub 37 |
|
|
|
| pdm2 37 |
|
|
|||
| nub 36 |
|
ManyToMany | |||
| pdm2 36 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | ceh-6 37 |
|
|
|
| ceh-18 36 |
|
OneToMany |
- Species with no ortholog for POU2F2:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for POU2F2 Gene
Paralogs for POU2F2 Gene
(14) SIMAP similar genes for POU2F2 Gene using alignment to 12 proteins:
Variants for POU2F2 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs7256977 | -- | 42,091,633(+) | CCGGG(C/T)CAGGG | intron-variant, downstream-variant-500B | |
| rs12985944 | -- | 42,098,064(+) | ggctc(A/C)caagt | intron-variant | |
| rs12985973 | -- | 42,098,093(+) | gcacc(A/C)ccgtg | intron-variant | |
| rs16975663 | -- | 42,089,564(+) | AAGAC(A/G)ACGTC | utr-variant-3-prime | |
| rs71167388 | -- | 42,098,247(+) | TCTCT(-/T)ATTAA | intron-variant |
Residual Variation Intolerance Score:
30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.32;
41.35% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for POU2F2 Gene
Disorders for POU2F2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| papilloma |
|
|
Search POU2F2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for POU2F2
No data available for UniProtKB/Swiss-Prot and Genatlas for POU2F2 Gene
Publications for POU2F2 Gene
- Short introns interrupting the Oct-2 POU domain may prevent recombination between POU family genes without interfering with potential POU domain 'shuffling' in evolution. (PMID: 7888080) Matsuo K. … Schaffner W. (Biol. Chem. Hoppe-Seyler 1994) 3 4 23 67
- A high throughput embryonic stem cell screen identifies Oct-2 as a bifunctional regulator of neuronal differentiation. (PMID: 19270158) Theodorou E. … Snyder M. (Genes Dev. 2009) 3 23
- Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression. (PMID: 16186795) Heckman C.A. … Boxer L.M. (Oncogene 2006) 3 23
- DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE. (PMID: 16103132) Malin S. … Pettersson S. (Nucleic Acids Res. 2005) 3 23
- NF-kappa B and Oct-2 synergize to activate the human 3' Igh hs4 enhancer in B cells. (PMID: 14707079) Sepulveda M.A. … Birshtein B.K. (J. Immunol. 2004) 3 23
Products for POU2F2 Gene
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Sources for POU2F2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
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