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POU2F2 Gene

protein-coding GIFtS: 60
GCID: GC19M042592

POU Class 2 Homeobox 2

(Previous names: POU domain class 2, transcription factor 2)
(Previous symbol: OTF2)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
POU Class 2 Homeobox 2¹ ²		OTF-2² ³
OTF2¹ ² ³ ⁵		Oct-2² ³
OCT2² ³ ⁵		POU Domain Class 2, Transcription Factor 2¹
Lymphoid-Restricted Immunoglobulin Octamer-Binding Protein NF-A2² ³		Homeobox Protein²
Octamer-Binding Protein 2² ³		POU Domain, Class 2, Transcription Factor 2²
Octamer-Binding Transcription Factor 2² ³

External Ids:	HGNC: 9213¹	Entrez Gene: 5452²	Ensembl: ENSG00000028277⁷	OMIM: 164176⁵	UniProtKB: P09086³

Export aliases for POU2F2 gene to outside databases

Previous GC identifers: GC19M043234 GC19M042986 GC19M047271 GC19M047286 GC19M039023

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POU2F2 Gene:

The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The

encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in

immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this

gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for POU2F2 Gene:

POU2F2 (POU class 2 homeobox 2) is a protein-coding gene. Diseases associated with POU2F2 include breast lymphoma, and primary effusion lymphoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein domain specific binding. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086

Function: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates

transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates

transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000019.10 NT_011109.17 NC_018930.2

Regulatory elements:

Regulatory transcription factor binding sites in the POU2F2 gene promoter:
NRSF form 1 NRSF form 2 Evi-1 E47 HNF-4alpha1 PPAR-gamma1 PPAR-gamma2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POU2F2 promoter sequence

Search Chromatin IP Primers for POU2F2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU2F2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

POU2F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU2F2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M042592: view genomic region (about GC identifiers)

Start:	42,590,263 bp from pter	End:	42,700,737 bp from pter
Size:	110,475 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086 (See protein sequence)

Recommended Name: POU domain, class 2, transcription factor 2

Size: 479 amino acids; 51209 Da

Subunit: Interacts with NR3C1, AR and PGR

Sequence caution: Sequence=CAA32039.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for POU2F2:

1HDP (3D)

Secondary accessions: Q16648 Q7M4M8 Q9BRS4

Alternative splicing: 5 isoforms: P09086-1 P09086-2 P09086-3 P09086-4 P09086-5 (Incomplete sequence)

Explore the universe of human proteins at neXtProt for POU2F2: NX_P09086

Explore proteomics data for POU2F2 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See POU2F2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts):

NP_001193954.1 NP_001193955.1 NP_001234923.1 NP_002689.1

ENSEMBL proteins:

ENSP00000373992 ENSP00000437221 ENSP00000452930 ENSP00000431603 ENSP00000437224

ENSP00000436100 ENSP00000453995 ENSP00000454179 ENSP00000453255 ENSP00000436988

ENSP00000471890 ENSP00000475664 ENSP00000476062 ENSP00000476240 ENSP00000339369

POU2F2 Human Recombinant Protein Products:

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	Novus Biologicals POU2F2 Protein Novus Biologicals POU2F2 Lysates
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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

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POU2F2 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for POU2F2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

POU: Homeoboxes / POU class

Selected InterPro protein domains (see all 7):

IPR010982 Lambda_DNA-bd_dom

IPR000972 TF_octamer

IPR013847 POU

IPR000327 POU_specific

IPR017970 Homeobox_CS

Graphical View of Domain Structure for InterPro Entry P09086

ProtoNet protein and cluster: P09086

3 Blocks protein domains:

IPB000327 POU domain

IPB000972 Octamer-binding transcription factor signature

IPB013847 POU

UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086

Similarity: Belongs to the POU transcription factor family. Class-2 subfamily

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 1 POU-specific domain

POU2F2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: PO2F2_HUMAN, P09086

Function: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates

transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates

transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter

Genatlas biochemistry entry for POU2F2:

POU domain,class 2,transcription factor 2,expressed in the immune system,also involved in the control of the

forebrain development and the cell-cell signaling process underlying the hypothalamic regulation of female

puberty

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0019904	protein domain specific binding	IEA	--
GO:0043565	sequence-specific DNA binding	IDA	9242494

POU2F2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for POU2F2:

Synthetic lethal with Ras

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pou2f2):

behavior/neurological	growth/size/body	hematopoietic system	homeostasis/metabolism	immune system
mortality/aging	respiratory system

POU2F2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for POU2F2: Pou2f2^tm1Bal Pou2f2^tm1Lmc

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POU2F2

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genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU2F2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU2F2

Transcription Factor Targeting:

Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer

Consensus sequence: ATATGCAAAT

miRNA Products:		miRTarBase miRNAs that target POU2F2: hsa-mir-9-5p (MIRT000639)

		Block miRNA regulation of human, mouse, rat POU2F2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate POU2F2 (see all 92):
		hsa-miR-218-1* hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3148 hsa-miR-3612 hsa-miR-3622a-5p hsa-miR-4289 hsa-miR-663

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Gene Editing
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		Browse Sino Biological Human cDNA Clones
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

PO2F2_HUMAN, P09086: Cytoplasm (By similarity). Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	9242494
GO:0005737	cytoplasm	IEA	--

POU2F2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for POU2F2 About

See pathways by source

SuperPath

Contained pathways About

B cell receptor signaling pathway (KEGG)

BCR signaling pathway

0.42

SIDS Susceptibility Pathways

SIDS Susceptibility Pathways

Development Glucocorticoid receptor signaling

Development Glucocorticoid receptor signaling

Pathways by source See SuperPaths
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for POU2F2

Development Glucocorticoid receptor signaling

2 BioSystems Pathways for POU2F2

	SIDS Susceptibility Pathways
	BCR signaling pathway

Pathway & Disease-focused RT² Profiler PCR Arrays including POU2F2:

T Helper Cell Differentiation in human mouse rat

Homeobox (HOX) Genes in human mouse rat

Interactions:

GeneGlobe Interaction Network for POU2F2

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

Selected Interacting proteins for POU2F2 (P09086³ ENSP00000373992⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MNAT1	P51948³, ENSP00000261245⁴	I2D: score=3 STRING: ENSP00000261245
NR3C1	P04150³, ENSP00000231509⁴	I2D: score=3 STRING: ENSP00000231509
XRCC6	P12956³, ENSP00000352257⁴	I2D: score=3 STRING: ENSP00000352257
TBP	P20226³, ENSP00000230354⁴	I2D: score=2 STRING: ENSP00000230354
AR	P10275³, ENSP00000363822⁴	I2D: score=1 STRING: ENSP00000363822

About this table

Gene Ontology (GO): Selected biological process terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002335	mature B cell differentiation	IEA	--
GO:0002380	immunoglobulin secretion involved in immune response	IEA	--
GO:0006355	regulation of transcription, DNA-templated	--	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	9442393
GO:0006959	humoral immune response	TAS	9442393

POU2F2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for POU2F2 (PO2F2)

7 Novoseek inferred chemical compound relationships for POU2F2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
okadaic acid	14.8	1	10727398 (1)
oligonucleotide	0	2	8026890 (1), 11368023 (1)
steroid	0	1	10433239 (1)
tyrosine	0	5	8672399 (4)
glutamate	0	8	14756804 (4), 16787415 (1), 1358756 (1)
gnrh	0	1	11036938 (1)
serine	0	1	2302733 (1)

POU2F2 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for POU2F2 gene (4 alternative transcripts):

NM_001207025.2 NM_001207026.1 NM_001247994.1 NM_002698.4

Unigene Cluster for POU2F2:

POU class 2 homeobox 2

Hs.147381 [show with all ESTs]

Unigene Representative Sequence: NM_001207025

Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000389341(uc002osn.3 uc002osq.3) ENST00000533720 ENST00000560804

ENST00000526816 ENST00000529067 ENST00000534559 ENST00000533548 ENST00000560558

ENST00000560398 ENST00000529952(uc002osr.2) ENST00000598842 ENST00000528894

ENST00000526831 ENST00000530982 ENST00000531773 ENST00000524801 ENST00000532176

ENST00000558596

miRNA Products:		Block miRNA regulation of human, mouse, rat POU2F2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate POU2F2 (see all 92):
		hsa-miR-218-1* hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3148 hsa-miR-3612 hsa-miR-3622a-5p hsa-miR-4289 hsa-miR-663

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		Predesigned siRNA for gene silencing in human, mouse, rat POU2F2

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		GenScript: all cDNA clones in your preferred vector: POU2F2 (NM_002698)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU2F2
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		Pre-validated RT² qPCR Primer Assay in human, mouse, rat POU2F2
		QuantiTect SYBR Green Assays in human, mouse, rat POU2F2
		QuantiFast Probe-based Assays in human, mouse, rat POU2F2

Additional mRNA sequence:

AL833648.1 BC006101.1 BT007438.1 M22596.1 M36542.1 M36653.1 M36718.1 M36772.1

X13809.1 X13810.1 X53468.1 X53469.1

16 DOTS entries:

DT.100785009 DT.99990511 DT.95069801 DT.100785010 DT.121453175 DT.91700060 DT.413141 DT.100785013

DT.413142 DT.413561 DT.65286027 DT.86836027 DT.91741185 DT.95069804 DT.97762188 DT.97775242

219 AceView cDNA sequences (see top 24):

BU428722 AA400730 M36718 BE465551 AI553728 AA832036 AA805083 AI208828

CF137658 CR604513 AA829950 BX100387 AI364649 AU186044 AA749285 AW166309

AA805157 BU430118 AA894446 CR594168 AA731643 BM810914 AW135115 AA011627

AI359226 X13809 AI241397 CA307156 M22596 BM452058 AW316809 CR615602

AI300318 BC006101 AI364695 BE675200 AA884256 AA417604 AA027348 AA805754

CK299118 AA732709 BI907587 AI192056 BI905873 BX367323 BF510728 BG685678

AA731213 BX401595 BG686022 BQ027393 AI393407 BX283460 BG230646 BM467285

AA648269 BG756240 BF062323 CF136594 AL833648 AA721210 BI911233 BX386801

BQ185656 CD251869 BX099450 BV189909 AI082494 AA744781 AA372027 AW269941

R85276 AI128484 AA372286 BX385121 AA251078 BQ185460 AA431272 AA830023

AA603319 BE560717 AA251181 AA814402 M36653 CF136979 BX342619 AW402109

AI949453 AI761000 BQ069989 X53468 AA432279 BM153100 BT007438 BV199625

BQ686388 N49616 AW337506 BX282790 AA948030 H24738 AA767331 BI906359

AW503080 AA806050 AI276232 AA831452 BQ021340 AI167252 AA814544 BI910933

AI051681 BI760102 AA393715 AW504990 X13810 R11531 AW408689 CF136724

AW503507 AW500355 CF136988 M36772 AW499994 AW505485 AI523570 AA810467

AW408011 AW406170 BG106848 AI568341 AW499986 BU623811 BX386800 BG758460

AA804651 AW136536 M36542 BE674891 BX385120 AA825272 AW576429 X53469

BU934681 AW963421 BG013933 AI703496 BM807954 NM_002698 BU430948 AW501434

AW505146 AA732618 AA255847 AA805767 AA713993 AA579229 AA633405 AW504770

AA873635 AW505453 H24737 H42723 T90110 AI439524 AA768396 BX367322

T82934 AW501449 AA419542 BF089205 AI365402 BG013953 AW474773 AW027117

AI207155 AW967458 BI906611 AA705030 H44829 AW138561 AW403492 AA741513

AA828351 AW500889 AW795467 AI657122 BX401594 H28302 AA634184 AW403460

BG024363 BX342618 AI762108 AW339820 AA744545 BU588855 H28301 BI908331

AA255997 AA738210 N46922 CB995118 BQ000822 T99553 BI912283 H44840

BU537113 AA806968 BF509229 AI568763 H42722 AI536070 BG119904 BG118380

AW977811 R10456 H26541

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for POU2F2 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	^	15	^	16	^	17	^	18	^
SP1:													-				-		-		-						-		-																		-				-
SP2:													-				-		-		-						-
SP3:													-				-										-
SP4:													-				-		-		-
SP5:																			-		-						-

ExUns:	19
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for POU2F2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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POU2F2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGGAGATGA

About this image

POU2F2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Smooth Muscle (Muscoskeletal System)
Juxtaglomerular Cells Afferent Arteriole

Kidney (Urinary System)
Juxtaglomerular Cells Afferent Arteriole

POU2F2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

POU2F2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.147381

UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086

Tissue specificity: Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the

immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147

Pathway & Disease-focused RT² Profiler PCR Arrays including POU2F2:

T Helper Cell Differentiation in human mouse rat

Homeobox (HOX) Genes in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for POU2F2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat POU2F2
		QuantiTect SYBR Green Assays in human, mouse, rat POU2F2
		QuantiFast Probe-based Assays in human, mouse, rat POU2F2

In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for POU2F2 gene from Selected species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pou2f2^{1 , 5}	POU domain, class 2, transcription factor 2^{1, 5}	94.6(n)¹ 98.45(a)¹		7 (13.73 cM)⁵ 18987¹ NM_001163554.1¹ NP_001157026.1¹ 25091114⁵
lizard (Anolis carolinensis)	Reptilia	POU2F2⁶	POU class 2 homeobox 2	47(a)	1 ↔ 1	GL343909.1(90878-109230)
tropical clawed frog (Xenopus tropicalis)	Amphibia	pou2f2¹	POU class 2 homeobox 2	66.74(n) 71.62(a)		100497329 XM_002936399.2 XP_002936445.2
zebrafish (Danio rerio)	Actinopterygii	pou2f2a¹	POU domain, class 2, transcription factor 2a	65.42(n) 68.3(a)		557055 XM_005173510.1 XP_005173567.1
fruit fly (Drosophila melanogaster)	Insecta	nub³	neuroblast determination transcription factor	74(a) (best of 2)		--
worm (Caenorhabditis elegans)	Secernentea	ceh-6³	Homeobox domain, Pou domain - N-terminal to homeobox more	55(a)		I(8506480-8510320) --

ENSEMBL Gene Tree for POU2F2 (if available)
TreeFam Gene Tree for POU2F2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for POU2F2 gene

POU5F2² POU6F2² POU4F2² POU2F3² POU3F1² POU3F4² POU1F1² POU3F3²

POU4F3² POU3F2² POU5F1B² POU4F1² POU2F1² POU6F1² POU5F1²

14 SIMAP similar genes for POU2F2 using alignment to 12 protein entries: PO2F2_HUMAN (see all proteins):

OCT-2 OCT6 POU2F3 POU1F1 POU6F1 POU2F1

POU5F1P1 POU5F1P4 POU3F1 POU5F1 POU5F1B POU4F3

POU3F2 POU3F4

POU2F2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12973044^1,2	A	--	42597161(+)	`tatatA/Tttttt`	4	--	int¹		0	--	--	--	--
rs190620972^1,2		--	42779628(+)	`TAATTG/TTTTTT`	3	--	ds500¹		0	--	--	--	--
rs201864010^1,2	C	--	42779640(+)	`TTTTG-/TTTTTT`	3	--	ds500¹		0	--	--	--	--
rs139978744^1,2	C	--	42779656(+)	`TTTTTA/GGACAA`	3	--	ds500¹		0	--	--	--	--
rs12460272^1,2	H	--	42779706(+)	`attacA/Ggttca`	3	--	ds500¹		0	--	--	--	--
rs141823307^1,2		--	42780197(+)	`TCAGAC/TGGAAC`	3	--	ut3¹		0	--	--	--	--
rs12992^1,2	C	--	42780230(+)	`AGGATG/TGAGGA`	3	--	ut3¹		3		MN NA	188
rs3760642^1,2	C,F,H	--	42780353(+)	`GGTGGT/CGAAAG`	3	--	ut3¹		4		EA NS NA	172
rs181862330^1,2		--	42780560(+)	`CTCTAC/TGAGTT`	3	--	ut3¹		0	--	--	--	--
rs200127549^1,2	C	--	42780569(+)	`TTGCC-/GAGAGAG`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for POU2F2 (42590263 - 42700737 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for POU2F2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv2496	CNV	Insertion	18451855
nsv520239	CNV	Loss	19592680
nsv911782	CNV	Loss	21882294
nsv911783	CNV	Loss	21882294
nsv522854	CNV	Gain	19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 164176 OMIM disorders: --

Selected diseases for POU2F2 (see all 27):
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breast lymphoma primary effusion lymphoma nodular lymphocyte predominant hodgkin lymphoma plasmacytoma

merkel cell carcinoma mediastinitis herpes simplex b-cell lymphomas

myeloma anaplastic large cell lymphoma diffuse large b-cell lymphoma conjunctivitis

papilloma kaposi's sarcoma acute myeloid leukemia multiple myeloma

lymphoblastic leukemia sarcoma myeloid leukemia hodgkin's lymphoma

POU2F2 for disorders About GeneDecksing

9 Novoseek inferred disease relationships for POU2F2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
latent infection	54.1	3	8396817 (1), 8139923 (1), 1654947 (1)
lymphoma b-cell	52.6	3	11904338 (1), 16778825 (1)
herpes simplex	45	3	8129727 (1), 8645173 (1), 7733899 (1)
lymphoma	41.4	17	11904338 (2), 16186795 (2), 11591767 (2), 7600290 (1) (see all 8)
plasmacytoma	21.7	2	11591767 (2)
hodgkin disease	19.3	2	14608905 (2)
myeloma	14.5	4	7600290 (2), 2107075 (1), 9598983 (1)
lymphoma non-hodgkins	0.603	2	11904338 (1), 14608905 (1)
tumors	0	2	1620122 (1), 19504395 (1)

Genetic Association Database (GAD): POU2F2
Human Genome Epidemiology (HuGE) Navigator: POU2F2 (5 documents)

Export disorders for POU2F2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for POU2F2 gene, integrated from 10 sources (see all 174):
(articles sorted by number of sources associating them with POU2F2)

Utopia: connect your pdf to the dynamic
world of online information

Short introns interrupting the Oct-2 POU domain may prevent recombination between POU family genes without interfering with potential POU domain 'shuffling' in evolution. (PubMed id 7888080)^{1, 2, 9} Matsuo K....Schaffner W. (Biol. Chem. Hoppe-Seyler 1994)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity. (PubMed id 19625999)^{1, 4} Filipski K.K....Sparreboom A. (Clin. Pharmacol. Ther. 2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter. (PubMed id 10480874)^{1, 2} Prefontaine G.G....Hache R.J.G. (J. Biol. Chem. 1999)
Solution structure of a POU-specific homeodomain: 3D-NMR studies of human B-cell transcription factor Oct-2. (PubMed id 7914745)^{1, 2} Sivaraja M.... Weiss M.A. (Biochemistry 1994)
Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells. (PubMed id 2328728)^{1, 2} Muller-Immergluck M.M.... Matthias P. (EMBO J. 1990)
A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. (PubMed id 2904653)^{1, 2} Mueller M.M.... Matthias P. (Nature 1988)
A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein. (PubMed id 2904654)^{1, 2} Scheidereit C.... Roder R.G. (Nature 1988)
A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain. (PubMed id 2901913)^{1, 2} Ko H.-S.... Staudt L.M. (Cell 1988)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5452	HGNC: 9213	AceView: POU2F2	Ensembl:ENSG00000028277	euGenes: HUgn5452
ECgene: POU2F2	H-InvDB: POU2F2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for POU2F2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for POU2F2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for POU2F2 gene:
Search GeneIP for patents involving POU2F2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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POU Class 2 Homeobox 2

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