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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU2F2 Gene

protein-coding   GIFtS: 60
GCID: GC19M042592

POU class 2 homeobox 2

(Previous names: POU domain class 2, transcription factor 2 )
(Previous symbol: OTF2)
 Explore 25 diseases affiliated with
POU2F2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for POU2F2    

Aliases
for POU2F2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
POU Class 2 Homeobox 21 2     OTF-22 3
OCT21 2 3 5     Oct-22 3
OTF21 2 3 5     POU Domain Class 2, Transcription Factor 21
Lymphoid-Restricted Immunoglobulin Octamer-Binding Protein NF-A22 3     Homeobox Protein2
Octamer-Binding Protein 22 3     POU Domain, Class 2, Transcription Factor 22
Octamer-Binding Transcription Factor 22 3     

External Ids:    HGNC: 92131   Entrez Gene: 54522   Ensembl: ENSG000000282777   OMIM: 1641765   UniProtKB: P090863   

Export aliases for POU2F2 gene to outside databases

Previous GC identifers: GC19M043234 GC19M042986 GC19M047271 GC19M047286 GC19M039023


Summaries
for POU2F2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for POU2F2:
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded
protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene
promoters. Several transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,
Oct 2011)

UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086
Function: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription
in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription
transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter




Genomic Views
for POU2F2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU2F2 gene promoter:
         NRSF form 1   NRSF form 2   Evi-1   E47   HNF-4alpha1   PPAR-gamma1   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POU2F2 promoter sequence
   Search SABiosciences Chromatin IP Primers for POU2F2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU2F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

POU2F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU2F2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M042592:  view genomic region     (about GC identifiers)

Start:
 42,592,650 bp from pter      End:
 42,700,737 bp from pter
Size:
 108,088 bases      Orientation:
 minus strand

Proteins
for POU2F2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086 (See protein sequence)
Recommended Name: POU domain, class 2, transcription factor 2  
Size: 479 amino acids; 51209 Da
Subunit: Interacts with NR3C1, AR and PGR
Subcellular location: Cytoplasm (By similarity). Nucleus
Sequence caution: Sequence=CAA32039.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for POU2F2:
1HDP (3D)    
Secondary accessions: Q16648 Q7M4M8 Q9BRS4
Alternative splicing: 5 isoforms:  P09086-1   P09086-2   P09086-3   P09086-4   P09086-5   (Incomplete sequence)

Explore the universe of human proteins at neXtProt for POU2F2: NX_P09086

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09086

    • POU2F2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001193954.1  NP_001193955.1  NP_001234923.1  NP_002689.1  

    ENSEMBL proteins: 
     ENSP00000373992   ENSP00000437221   ENSP00000452930   ENSP00000431603   ENSP00000437224  
     ENSP00000436100   ENSP00000453995   ENSP00000454179   ENSP00000453255   ENSP00000436988  
     ENSP00000454056   ENSP00000431679   ENSP00000453164   ENSP00000453794   ENSP00000339369  
     ENSP00000292077  

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    Novus Biologicals POU2F2 Lysates
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9242494
    GO:0005737cytoplasm IEA--


    POU2F2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for POU2F2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    POU2F2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR000972 TF_octamer
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS

    Graphical View of Domain Structure for InterPro Entry P09086

    ProtoNet protein and cluster: P09086

    3 Blocks protein families:
    IPB000327 POU domain
    IPB000972 Octamer-binding transcription factor signature
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086
    Similarity: Belongs to the POU transcription factor family. Class-2 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    Function
    for POU2F2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086
    Function: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription
    in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription
    transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter

         Genatlas biochemistry entry for POU2F2:
    POU domain,class 2,transcription factor 2,expressed in the immune system,also involved in the control of the forebrain
    development and the cell-cell signaling process underlying the hypothalamic regulation of female puberty

    10/229 SABiosciences Target genes for POU2F2 (see all 229):
    ACADM ADCY3 ADH1C AGBL1 AMIGO3 ANKRD39 AOAH AP2A2 AP3S1 AQP7P1

    miRNA
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    hsa-mir-9 (MIRT000639)

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    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate POU2F2 (see all 92):
    hsa-miR-218-1* hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3148 hsa-miR-3612 hsa-miR-3622a-5p hsa-miR-4289 hsa-miR-663
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: POU2F2
    OriGene siRNA: POU2F2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU2F2

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0019904protein domain specific binding IEA--
    GO:0043565sequence-specific DNA binding IDA9242494


    POU2F2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for POU2F2:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for POU2F2: Pou2f2tm1Bal Pou2f2tm1Lmc
         8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pou2f2):
     behavior/neurological  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  respiratory system 

    POU2F2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for POU2F2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    		Development Glucocorticoid receptor signaling0.27
    		Development_Glucocorticoid receptor signaling0.27
    2SIDS Susceptibility Pathways
    		SIDS Susceptibility Pathways1.00
    3B cell receptor signaling pathway
    		BCR signaling pathway0.41

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for POU2F2
        Development Glucocorticoid receptor signaling


    1 GeneGo (Thomson Reuters) Pathway for POU2F2
        Development Glucocorticoid receptor signaling

    2 BioSystems Pathways for POU2F2 
        SIDS Susceptibility Pathways
    BCR signaling pathway



    POU2F2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU2F2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/17 Interacting proteins for POU2F2 (P090863 ENSP000003739924) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MNAT1P519483, ENSP000002612454I2D: score=3 STRING: ENSP00000261245
    NR3C1P041503, ENSP000002315094I2D: score=3 STRING: ENSP00000231509
    XRCC6P129563, ENSP000003522574I2D: score=3 STRING: ENSP00000352257
    TBPP202263, ENSP000002303544I2D: score=2 STRING: ENSP00000230354
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002335mature B cell differentiation IEA--
    GO:0002380immunoglobulin secretion involved in immune response IEA--
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS9442393


    POU2F2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for POU2F2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POU2F2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POU2F2
    7 Novoseek chemical compound relationships for POU2F2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    okadaic acid 14.8 1 10727398 (1)
    oligonucleotide 0 2 8026890 (1), 11368023 (1)
    steroid 0 1 10433239 (1)
    tyrosine 0 5 8672399 (4)
    glutamate 0 8 14756804 (4), 16787415 (1), 1358756 (1)
    gnrh 0 1 11036938 (1)
    serine 0 1 2302733 (1)

    Search CenterWatch for drugs/clinical trials and news about POU2F2 / PO2F2 

    Transcripts
    for POU2F2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for POU2F2 gene (4 alternative transcripts): 
    NM_001207025.2  NM_001207026.1  NM_001247994.1  NM_002698.4  

    Unigene Cluster for POU2F2:

    POU class 2 homeobox 2
    Hs.147381  [show with all ESTs]
    Unigene Representative Sequence: NM_001207025
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000389341(uc002osn.3 uc002osq.3) ENST00000533720 ENST00000560804
    ENST00000526816 ENST00000529067 ENST00000534559 ENST00000533548 ENST00000560558
    ENST00000560398 ENST00000529952(uc002osr.2) ENST00000528894 ENST00000526831
    ENST00000530982 ENST00000531773 ENST00000524801 ENST00000532176 ENST00000526933
    ENST00000558596

    miRNA
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    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate POU2F2 (see all 92):
    hsa-miR-218-1* hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3148 hsa-miR-3612 hsa-miR-3622a-5p hsa-miR-4289 hsa-miR-663
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    Inhib. RNA
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    OriGene shRNA RFP: POU2F2
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    Clone
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    Additional cDNA sequence: 

    AL833648.1 BC006101.1 BT007438.1 M22596.1 M36542.1 M36653.1 M36718.1 M36772.1 
    X13809.1 X13810.1 X53468.1 X53469.1 

    16 DOTS entries:

    DT.100785009  DT.99990511  DT.95069801  DT.100785010  DT.121453175  DT.91700060  DT.413141  DT.100785013 
    DT.413142  DT.413561  DT.65286027  DT.86836027  DT.91741185  DT.95069804  DT.97762188  DT.97775242 

    219 AceView cDNA sequences (see top 24):

    AA832036 AA417604 CR604513 AW316809 BM810914 AA731643 CR615602 AW135115 
    BE675200 AA894446 AU186044 AA011627 AA829950 M36718 CF137658 CA307156 
    AI364649 BU430118 AA805083 AW166309 AI553728 AI300318 AI208828 AA884256 
    BM452058 AI241397 BX100387 CR594168 BE465551 M22596 AI364695 AA805157 
    X13809 BC006101 AA749285 BU428722 AI359226 AA400730 AA431272 AA648269 
    AA805754 AA372027 M36653 BI905873 AW337506 AA721210 BV189909 CD251869 
    CK299118 AA731213 CF136594 R85276 BQ185460 H24738 AW269941 BQ686388 
    AA251078 AA744781 AA830023 BI760102 AA393715 BM467285 AA603319 AI082494 
    BG230646 BX367323 AI393407 BF510728 AL833648 BE560717 BX283460 BF062323 
    BX342619 BX099450 BG686022 AW503080 BI906359 AA814544 BM153100 BQ069989 
    AA831452 BI910933 AA767331 BX282790 BT007438 BI907587 BX386801 AA027348 
    AA806050 BQ027393 AA814402 AA251181 BQ021340 AI167252 AA732709 AI192056 
    AA372286 AI128484 AW402109 BG756240 AI276232 CF136979 BG685678 AI051681 
    BX385121 BX401595 BV199625 AI949453 AI761000 BI911233 AA948030 X53468 
    AA432279 BQ185656 N49616 CF136724 AW576429 AW499994 AA805767 AW408689 
    AA579229 AW505146 BG013933 BE674891 AI703496 AI568341 R11531 AW136536 
    AA804651 M36772 AA255847 M36542 AW503507 AW501434 BX385120 AA732618 
    AW500355 NM_002698 BU430948 AA810467 X53469 AW504990 BG106848 AW499986 
    AW406170 AI523570 BX386800 X13810 AW505485 BG758460 CF136988 AA713993 
    AA825272 AW408011 BU934681 BU623811 AW963421 BM807954 AW504770 AW505453 
    AA633405 T90110 AW967458 AA419542 AW403492 AA768396 AW501449 H44829 
    AW027117 BG013953 AW474773 H42723 AW138561 AA741513 AI365402 BF089205 
    BI906611 BX367322 AI439524 AA873635 H24737 T82934 AA705030 AI207155 
    BI908331 AA828351 H28301 BX401594 H28302 BG024363 AW403460 AW500889 
    BX342618 AW339820 AA744545 BU588855 AI762108 AI657122 AW795467 AA634184 
    T99553 AA255997 AA738210 N46922 BQ000822 BI912283 CB995118 BG119904 
    BF509229 H42722 H44840 AI536070 BU537113 AA806968 AI568763 AW977811 
    R10456 H26541 BG118380 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for POU2F2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                                      -           -     -     -                 -     -                                                     -           -   
    SP2:                                      -           -     -     -                 -                                                                           
    SP3:                                      -           -                             -                                                                           
    SP4:                                      -           -     -     -                                                                                             
    SP5:                                                        -     -                 -                                                                           

    ExUns: 19
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for POU2F2

    Expression
    for POU2F2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU2F2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGAGATGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    POU2F2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainHypothalamusBrain
    BrainThalamusBrain
    Neural TubeDiencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See POU2F2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POU2F2

    SOURCE GeneReport for Unigene cluster: Hs.147381

    UniProtKB/Swiss-Prot: PO2F2_HUMAN, P09086
    Tissue specificity: Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing
    T-cell line MOLT-4, but not in the T-cell line BW5147

        SABiosciences Expression via Pathway-Focused PCR Arrays including POU2F2: 
              T Helper Cell Differentiation in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for POU2F2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for POU2F2 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia POU2F26
    		 --
    		 42(a)
    		 1 ↔ 1
    		 GL343909.1(96375-106147)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005349341 POU domain, class 2, transcription factor 2-like 66.98(n)
    70.26(a)    		   100534934  XM_003200146.1  XP_003200194.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta nub3 neuroblast determination transcription
    factor    		 74(a)
    (best of 2)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea ceh-63 Homeobox domain, Pou domain - N-terminal to
    homeobox more    		 55(a)   I(8506480-8510320)   --


    ENSEMBL Gene Tree for POU2F2 (if available)
    TreeFam Gene Tree for POU2F2 (if available) 

    Paralogs
    for POU2F2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POU2F2 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F42  POU3F12  POU1F12  POU4F32  
    POU3F32  POU3F22  POU5F1B2  POU2F12  POU4F12  POU5F12  POU6F12  
    14 SIMAP similar genes for POU2F2 using alignment to 13 protein entries:     PO2F2_HUMAN (see all proteins):
    OCT-2    OCT6    POU2F3    POU2F1    POU1F1    POU6F1
    POU3F1    POU5F1P4    POU5F1P1    POU5F1B    POU4F3    POU3F2
    POU3F4    POU5F1

    POU2F2 for paralogs           About GeneDecksing



    Genomic Variants
    for POU2F2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/529 NCBI SNPs in POU2F2 are shown (see all 529)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs124602721,2
    		H--39020907(+) attacA/Ggttca 3 -- ds50010--------
    rs129921,2
    		C--39021431(+) AGGATG/TGAGGA 3 -- ut313Minor allele frequency- T:0.00MN NA 188
    rs37606421,2
    		C,F,H--39021554(+) GGTGGT/CGAAAG 3 -- ut314Minor allele frequency- C:0.01EA NS NA 172
    rs797310151,2
    		F,--39022610(+) CACACC/ACACCC 3 -- ut311Minor allele frequency- A:0.03WA 118
    rs11527121,2
    		C,F,H,--39023021(+) ACCAGA/CGTGTA 3 -- ut3111Minor allele frequency- C:0.19MN NS NA WA 1546
    rs104254021,2
    		C,H--39023847(+) GCGGAG/AATGCT 3 -- ut316Minor allele frequency- A:0.00NS EA NA 420
    rs104256821,2
    		C,F,H--39023991(+) GCCCAG/ACCCAA 3 -- ut318Minor allele frequency- A:0.01NS EA NA 1044
    rs2011402491,2
    		C--39024186(+) GGCTGG/TCAGGC 3 -- ut310--------
    rs739328721,2
    		C,--39024193(+) AGGCCC/GCACCC 3 -- ut312Minor allele frequency- G:0.03WA 120
    rs770745191,2
    		--39024960(+) GAGACA/GTGTCC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for POU2F2 (42592650 - 42700737 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for POU2F2: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for POU2F2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    POU2F2 for disorders           About GeneDecksing

    OMIM gene information: 164176    OMIM disorders: --

    20/25 diseases for POU2F2 (see all 25):    About MalaCards
    diffuse large b-cell lymphoma    b-cell lymphomas    primary effusion lymphoma    herpes simplex
    plasmacytoma    merkel cell carcinoma    acute lymphoblastic leukemia    lymphoblastic leukemia
    acute myeloid leukemia    myeloid leukemia    kaposi's sarcoma    hodgkin's lymphoma
    multiple myeloma    mediastinitis    myeloma    papilloma
    hermaphroditism    conjunctivitis    breast lymphoma    leukemia

    9 Novoseek disease relationships for POU2F2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    latent infection 54.1 3 8396817 (1), 8139923 (1), 1654947 (1)
    lymphoma b-cell 52.6 3 11904338 (1), 16778825 (1)
    herpes simplex 45 3 8129727 (1), 8645173 (1), 7733899 (1)
    lymphoma 41.4 17 11904338 (2), 16186795 (2), 11591767 (2), 7600290 (1) (see all 8)
    plasmacytoma 21.7 2 11591767 (2)
    hodgkin disease 19.3 2 14608905 (2)
    myeloma 14.5 4 7600290 (2), 2107075 (1), 9598983 (1)
    lymphoma non-hodgkins 0.603 2 11904338 (1), 14608905 (1)
    tumors 0 2 1620122 (1), 19504395 (1)

    Human Genome Epidemiology (HuGE) Navigator: POU2F2 (5 documents)

    Export disorders for POU2F2 gene to outside databases

    Publications
    for POU2F2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU2F2 gene, integrated from 9 sources (see all 172):
    (articles sorted by number of sources associating them with POU2F2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Short introns interrupting the Oct-2 POU domain may prevent recombination between POU family genes without interfering with potential POU domain 'shuffling' in evolution. (PubMed id 7888080)1, 2, 9 Matsuo K....Schaffner W. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter. (PubMed id 10480874)1, 2 Prefontaine G.G....Hache R.J.G. (1999)
    4. Solution structure of a POU-specific homeodomain: 3D-NMR studies of human B-cell transcription factor Oct-2. (PubMed id 7914745)1, 2 Sivaraja M.... Weiss M.A. (1994)
    5. Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells. (PubMed id 2328728)1, 2 Muller-Immergluck M.M.... Matthias P. (1990)
    6. A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. (PubMed id 2904653)1, 2 Mueller M.M.... Matthias P. (1988)
    7. A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein. (PubMed id 2904654)1, 2 Scheidereit C.... Roder R.G. (1988)
    8. A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain. (PubMed id 2901913)1, 2 Ko H.-S.... Staudt L.M. (1988)
    9. The B-cell-specific Oct-2 protein contains POU box- and homeo box- type domains. (PubMed id 3265124)1, 2 Clerc R.G.... Sharp P.A. (1988)
    10. Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression. (PubMed id 16186795)1, 9 Heckman C.A....Boxer L.M. (2006)

    External Searches for POU2F2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing POU2F2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5452 HGNC: 9213 AceView: POU2F2 Ensembl:ENSG00000028277 euGenes: HUgn5452
    ECgene: POU2F2 H-InvDB: POU2F2

    Other Databases showing POU2F2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing POU2F2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POU2F2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for POU2F2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for POU2F2 gene:
    Search GeneIP for patents involving POU2F2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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