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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU2F1 Gene

protein-coding   GIFtS: 67
GCID: GC01P167190

POU Class 2 Homeobox 1

(Previous names: POU domain class 2, transcription factor 1)
(Previous symbol: OTF1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
POU Class 2 Homeobox 11 2     POU Domain Class 2, Transcription Factor 11
OTF11 2 3 5     oct-12
OCT12 3 5     oct-1B2
Octamer-Binding Protein 12 3     Octamer-Binding Transcription Factor-12
Octamer-Binding Transcription Factor 12 3     POU Domain, Class 2, Transcription Factor 12
NF-A12 3     Oct-13
OTF-12 3     

External Ids:    HGNC: 92121   Entrez Gene: 54512   Ensembl: ENSG000001431907   OMIM: 1641755   UniProtKB: P148593   
ORGUL members:    fRNAdb10:FR346925      
H-InvDB12:HIT000216140    
NCBI13:S66902    
NONCODE14:n410211 n338347 n326339 n345471      
RNAdb15:HIV1154    

Export aliases for POU2F1 gene to outside databases

Previous GC identifers: GC01P164826 GC01P162840 GC01P163886 GC01P164377 GC01P163921 GC01P165456 GC01P138436


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POU2F1 Gene:
The OCT1 transcription factor was among the first identified members of the POU transcription factor family
(summarized by Sturm et al., 1993 (PubMed 8314572)). Members of this family contain the POU domain, a 160-amino
acid region necessary for DNA binding to the octameric sequence ATGCAAAT.(supplied by OMIM, Jul 2010)

GeneCards Summary for POU2F1 Gene: 
POU2F1 (POU class 2 homeobox 1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with POU2F1 include hereditary persistence of fetal hemoglobin, and varicose veins, and among its related super-pathways are RNA Polymerase III Transcription Initiation From Type 3 Promoter and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the
genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins.
Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex
virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and
HCFC1 thereby enabling the transcription of the viral immediate early genes

Gene Wiki entry for POU2F1 Gene

fRNAdb sequence ontology for POU2F1:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for POU2F1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU2F1 gene promoter:
         SRF   AP-2alpha isoform 3   SRF (504 AA)   Nkx2-5   STAT5A   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOU2F1 promoter sequence
   Search SABiosciences Chromatin IP Primers for POU2F1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU2F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.2   Ensembl cytogenetic band:  1q24.1   HGNC cytogenetic band: 1q24.2

POU2F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU2F1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P167190:  view genomic region     (about GC identifiers)

Start:
167,190,066 bp from pter      End:
167,396,582 bp from pter
Size:
206,517 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for POU2F1

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859 (See protein sequence)
Recommended Name: POU domain, class 2, transcription factor 1  
Size: 743 amino acids; 76472 Da
Subunit: Interacts with NR3C1, AR, PGR and HCFC1. Associates with the herpes simplex virus VP16-induced complex;
binding to HCFC1 activates the viral transcriptional activator VP16 for association with POU2F1, to form a
multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes
Subcellular location: Nucleus
6/8 PDB 3D structures from and Proteopedia for POU2F1 (see all 8):
1CQT (3D)        1E3O (3D)        1GT0 (3D)        1HF0 (3D)        1O4X (3D)        1OCT (3D)    
Secondary accessions: B1AL91 B1AL93 B4E029 Q5TBT7 Q6PK46 Q8NEU9 Q9BPV1
Alternative splicing: 5 isoforms:  P14859-1   P14859-2   P14859-3   P14859-4   P14859-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for POU2F1: NX_P14859

Explore proteomics data for POU2F1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by PRKDC
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14859

  • POU2F1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    POU2F1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001185712.1  NP_001185715.1  NP_002688.3  

    ENSEMBL proteins: 
     ENSP00000356840   ENSP00000453135   ENSP00000404571   ENSP00000453094   ENSP00000401217  
     ENSP00000271411   ENSP00000356836   ENSP00000415993   ENSP00000414660   ENSP00000441285  
     ENSP00000391523  
    Reactome Protein details: P14859
    Human Recombinant Protein Products for POU2F1: 
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    Novus Biologicals POU2F1 Protein
    Novus Biologicals POU2F1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11891224
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex ----

    POU2F1 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    POU: Homeoboxes / POU class

    5/7 InterPro protein domains (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR000972 TF_octamer
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS

    Graphical View of Domain Structure for InterPro Entry P14859

    ProtoNet protein and cluster: P14859

    3 Blocks protein domains:
    IPB000327 POU domain
    IPB000972 Octamer-binding transcription factor signature
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859
    Similarity: Belongs to the POU transcription factor family. Class-2 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    POU2F1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO2F1_HUMAN, P14859
    Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the
    genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins.
    Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex
    virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and
    HCFC1 thereby enabling the transcription of the viral immediate early genes

         Genatlas biochemistry entry for POU2F1:
    POU domain,class 2,transcription factor 1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ----
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10629049
    GO:0043565sequence-specific DNA binding IDA11997177
         
    POU2F1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for POU2F1:
     Increased cell number in S and 

         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pou2f1):
     behavior/neurological  craniofacial  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  integument  liver/biliary system  mortality/aging  nervous system 
     respiratory system  taste/olfaction  vision/eye 

    POU2F1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for POU2F1: Pou2f1tm1Cav Cd247/Pou2f1Cd247/tm1Tks

       inGenious Targeting Laboratory - Custom generated mouse model solutions for POU2F1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POU2F1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU2F1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU2F1 

    10/2634 SABiosciences Target genes for POU2F1 (see all 2634):
    A1CF A3GALT2 A4GNT AAA1 AADAC AARS2 AASDH AASDHPPT AATK ABCA13

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU2F1
    277 QIAGEN miScript miRNA Assays for microRNAs that regulate POU2F1 (see first 8):
    hsa-miR-579 hsa-miR-605 hsa-miR-1273d hsa-miR-3622b-3p hsa-miR-761 hsa-miR-520b hsa-miR-3690 hsa-miR-34c-5p
    hsa-miR-186* hsa-miR-23c hsa-miR-520c-3p hsa-miR-608 hsa-miR-16 hsa-miR-18b hsa-miR-498 hsa-miR-448
    hsa-miR-20b* hsa-miR-515-5p hsa-miR-144 hsa-miR-125b hsa-miR-922 hsa-miR-302a hsa-miR-888 hsa-miR-3913-5p
    hsa-miR-654-3p hsa-miR-562 hsa-miR-19b-2* hsa-miR-4328 hsa-let-7d hsa-miR-513a-5p hsa-miR-503 hsa-miR-29a
    hsa-miR-105 hsa-miR-570 hsa-let-7g hsa-miR-1184 hsa-miR-9 hsa-miR-124 hsa-miR-133a hsa-miR-1290
    hsa-miR-3163 hsa-miR-222* hsa-miR-3120-3p hsa-miR-3681* hsa-miR-3155 hsa-miR-1301 hsa-miR-181a hsa-miR-548aa
    hsa-miR-519b-3p hsa-miR-182* hsa-miR-195* hsa-miR-148b* hsa-miR-34b* hsa-miR-125a-5p hsa-miR-3129-5p hsa-miR-450b-3p
    hsa-miR-512-3p hsa-miR-548g hsa-miR-204 hsa-let-7g* hsa-miR-205* hsa-miR-3662 hsa-miR-520d-3p hsa-miR-18b*
    hsa-miR-195 hsa-miR-487b hsa-miR-450b-5p hsa-miR-96 hsa-miR-1289 hsa-miR-519d hsa-miR-2278 hsa-miR-3924
    hsa-miR-3907 hsa-miR-181d hsa-miR-504 hsa-miR-935 hsa-miR-214 hsa-miR-9* hsa-miR-607 hsa-miR-3607-3p
    hsa-miR-520e hsa-miR-218-1* hsa-miR-890 hsa-miR-3122 hsa-miR-4274 hsa-miR-93 hsa-miR-155* hsa-miR-376c
    hsa-miR-647 hsa-miR-4300 hsa-miR-554 hsa-let-7i hsa-miR-3667-3p hsa-miR-920 hsa-miR-548t hsa-miR-23b
    hsa-miR-101 hsa-miR-362-3p hsa-miR-16-2* hsa-miR-539 hsa-miR-548a-3p hsa-miR-520a-3p hsa-miR-31* hsa-miR-31
    hsa-miR-634 hsa-miR-133b hsa-let-7b hsa-miR-544 hsa-miR-143 hsa-miR-4302 hsa-miR-2052 hsa-miR-139-5p
    hsa-miR-486-3p hsa-miR-449a hsa-miR-507 hsa-miR-3167 hsa-miR-374c hsa-miR-223 hsa-let-7a hsa-miR-889
    hsa-miR-526b* hsa-miR-4257 hsa-miR-98 hsa-miR-3065-3p hsa-miR-381 hsa-miR-519c-3p hsa-miR-519e* hsa-miR-211
    hsa-miR-1185 hsa-miR-19b hsa-miR-593* hsa-miR-129-5p hsa-miR-181c hsa-miR-302e hsa-miR-885-5p hsa-miR-3680
    hsa-miR-3143 hsa-miR-493 hsa-miR-205 hsa-miR-224 hsa-miR-18a hsa-miR-3679-5p hsa-miR-659 hsa-miR-19a*
    hsa-miR-20b hsa-miR-100* hsa-miR-640 hsa-miR-1321 hsa-miR-631 hsa-miR-1224-3p hsa-miR-106a hsa-miR-199a-3p
    hsa-miR-128 hsa-miR-1245 hsa-miR-3653 hsa-miR-519a hsa-miR-138-2* hsa-miR-877* hsa-miR-130a* hsa-miR-4255
    hsa-miR-3683 hsa-miR-3914 hsa-let-7e hsa-miR-4279 hsa-miR-466 hsa-miR-3616-3p hsa-miR-1287 hsa-miR-320a
    hsa-miR-875-3p hsa-miR-4288 hsa-miR-555 hsa-let-7c hsa-miR-486-5p hsa-miR-3605-5p hsa-miR-3692 hsa-miR-548c-3p
    hsa-miR-17 hsa-miR-299-5p hsa-miR-196a* hsa-miR-3130-3p hsa-miR-876-5p hsa-miR-106a* hsa-miR-3137 hsa-miR-582-5p
    hsa-miR-320b hsa-miR-182 hsa-miR-656 hsa-miR-19b-1* hsa-miR-543 hsa-miR-449c hsa-miR-3685 hsa-miR-4291
    hsa-miR-3664-5p hsa-miR-548k hsa-miR-424 hsa-miR-506 hsa-miR-23a hsa-miR-302b hsa-miR-181b hsa-miR-449b
    hsa-miR-548e hsa-miR-4282 hsa-miR-337-3p hsa-miR-302c hsa-miR-655 hsa-miR-670 hsa-miR-3670 hsa-miR-4319
    hsa-miR-4286 hsa-miR-199b-3p hsa-miR-4251 hsa-miR-202 hsa-miR-331-3p hsa-miR-410 hsa-miR-606 hsa-miR-3941
    hsa-miR-3155b hsa-miR-577 hsa-miR-646 hsa-miR-329 hsa-miR-151-3p hsa-miR-153 hsa-miR-494 hsa-miR-19a
    hsa-miR-4262 hsa-miR-300 hsa-miR-15a hsa-miR-632 hsa-miR-219-5p hsa-miR-3161 hsa-miR-29a* hsa-miR-20a
    hsa-miR-601 hsa-miR-1298 hsa-miR-324-3p hsa-miR-373 hsa-miR-3920 hsa-miR-874 hsa-miR-3934 hsa-miR-3673
    hsa-miR-944 hsa-miR-340 hsa-miR-1286 hsa-miR-140-3p hsa-miR-569 hsa-miR-3166 hsa-miR-106b hsa-miR-497
    hsa-miR-484 hsa-let-7f hsa-let-7f-2* hsa-miR-302d hsa-miR-1197 hsa-let-7a-2* hsa-miR-346 hsa-miR-218
    hsa-miR-372 hsa-miR-3658 hsa-miR-497* hsa-miR-15b hsa-miR-320d hsa-miR-4290 hsa-miR-3652 hsa-miR-495
    hsa-miR-548v hsa-miR-29c hsa-miR-1271 hsa-miR-3661 hsa-miR-1205 hsa-miR-891b hsa-miR-1208 hsa-miR-589
    hsa-miR-3671 hsa-miR-589* hsa-miR-34a hsa-miR-936 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidPOU2F1 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for POU2F1 About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase III Transcription Initiation
    RNA Polymerase III Transcription Initiation0.80
    RNA Polymerase III Transcription Initiation From Type 3 Promoter0.80
    RNA Polymerase III Transcription0.80
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.59
    RNA Polymerase III Abortive And Retractive Initiation0.80
    2Calcium signaling in the CD4+ TCR pathway
    Calcium signaling in the CD4+ TCR pathway0.38
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes0.38
    3Transcription
    Transcription0.69
    4PKC-Theta Pathway
    PKC-Theta Pathway0.68
    5Development Glucocorticoid receptor signaling
    Development Glucocorticoid receptor signaling1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for POU2F1
        Development Glucocorticoid receptor signaling
    Immune response IL-3 activation and signaling pathway

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POU2F1
        BRCA1 Pathway
    Glucocorticoid Receptor Signaling
    PKC-Theta Pathway

    2 GeneGo (Thomson Reuters) Pathways for POU2F1
        Immune response IL-3 activation and signaling pathway
    Development Glucocorticoid receptor signaling

    5/6 BioSystems Pathways for POU2F1 (see all 6)
        ATF-2 transcription factor network
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    Regulation of Androgen receptor activity
    Glucocorticoid receptor regulatory network
    Calcium signaling in the CD4+ TCR pathway


    5/7        Reactome Pathways for POU2F1 (see all 7)
        RNA Polymerase III Transcription Initiation
    RNA Polymerase III Transcription Initiation From Type 3 Promoter
    Transcription
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
    RNA Polymerase III Transcription



    POU2F1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU2F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/100 Interacting proteins for POU2F1 (P148591, 2, 3 ENSP000002714114) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TEAD1P283472, 3, ENSP000003545884MINT-73316 I2D: score=1 STRING: ENSP00000354588
    SP1P080471, 2, 3, ENSP000003293574EBI-624770,EBI-298336 MINT-6803426 MINT-6803452 MINT-6803484 MINT-6803438 MINT-6803470 I2D: score=4 STRING: ENSP00000329357
    ENSG00000228321P013753, ENSP000003928584I2D: score=1 STRING: ENSP00000392858
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006383transcription from RNA polymerase III promoter TAS--
    GO:0010467gene expression TAS--
    GO:0030910olfactory placode formation ----
    GO:0045892negative regulation of transcription, DNA-dependent IDA11891224

    POU2F1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POU2F1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POU2F1 (PO2F1)

    10/16 Novoseek inferred chemical compound relationships for POU2F1 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-napc 78.7 15 9188510 (4), 11463379 (3), 9832505 (2), 9418884 (2)
    gnrh 27.2 8 12188930 (2), 16002402 (2), 15319450 (2), 10674395 (1)
    diamide 23.8 2 9115711 (1), 9489510 (1)
    retinoic acid 13.7 9 7646519 (4), 8455626 (3), 14993281 (1)
    zinc 9.13 8 10455183 (3), 9111349 (1), 7568211 (1), 14669980 (1) (see all 5)
    glyceraldehyde 3-phosphate 8.59 5 12887926 (1), 18682386 (1), 16301215 (1)
    oligonucleotide 6.28 5 8026890 (1), 9518258 (1), 14729276 (1)
    calcium 1.5 1 8964085 (1)
    nitric oxide 0 16 9489510 (6), 19467240 (1), 10674395 (1)
    cyclic amp 0 2 15336700 (1), 14993281 (1)

    Search CenterWatch for drugs/clinical trials and news about POU2F1 / PO2F1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for POU2F1 gene (3 alternative transcripts): 
    NM_001198783.1  NM_001198786.1  NM_002697.3  

    Unigene Cluster for POU2F1:

    POU class 2 homeobox 1
    Hs.283402  [show with all ESTs]
    Unigene Representative Sequence: NM_001198783
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000367866(uc001geg.3 uc001gee.3 uc010plh.2) ENST00000559038
    ENST00000557909 ENST00000558944 ENST00000442313 ENST00000560232 ENST00000429375
    ENST00000492850 ENST00000367865(uc001ged.3) ENST00000271411(uc010plg.2 uc001gec.3)
    ENST00000367862(uc001gef.3) ENST00000557874 ENST00000470928 ENST00000443275(uc009wvg.1)
    ENST00000490100 ENST00000559648 ENST00000420254 ENST00000541643
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/277 QIAGEN miScript miRNA Assays for microRNAs that regulate POU2F1 (see all 277):
    hsa-miR-579 hsa-miR-605 hsa-miR-1273d hsa-miR-3622b-3p hsa-miR-761 hsa-miR-520b hsa-miR-3690 hsa-miR-34c-5p
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    Additional mRNA sequence: 

    AK091438.1 AK124826.1 AK303201.1 AK308004.1 AY113189.1 BC001664.2 BC003571.1 BC007388.2 
    BC037864.2 BC052274.1 CR627124.1 NR_037163.1 S66901.1 X13403.1 

    22 DOTS entries:

    DT.95140199  DT.95171994  DT.312945  DT.100788108  DT.101983687  DT.92434662  DT.203889  DT.309153 
    DT.100788111  DT.121436911  DT.100808918  DT.121436837  DT.100026449  DT.121436891  DT.437142  DT.91839750 
    DT.95171990  DT.95348533  DT.99934717  DT.100739535  DT.86848723  DT.92021422 

    24/145 AceView cDNA sequences (see all 145):

    BQ938715 BQ213592 S66902 BE385281 AU122313 NM_002697 AU124383 BP339121 
    BQ928677 BC041822 BC007388 BG752224 BC001664 BQ962465 S66901 BG388369 
    BE269179 BC052274 BM040945 BE560757 BE396853 BM782895 BC003571 BQ068393 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for POU2F1 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
    SP1:                          -           -     -     -           -     -     -                                                     -                           
    SP2:                                                              -     -     -                                                     -                           
    SP3:                          -     -     -     -     -           -     -     -                                                     -                           
    SP4:                                                                                                                                -                           
    SP5:                                                              -     -     -                                               -     -                           

    ExUns: 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                            -     -         
    SP5:                                                            


    ECgene alternative splicing isoforms for POU2F1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU2F1 expression in normal human tissues (normalized intensities)      POU2F1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTGGAGAA
    POU2F1 Expression
    About this image


    POU2F1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             seminal vesicle ; glandular cells   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Islets of Langerhans
             pancreas ; exocrine glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 2 entries
             salivary gland ; glandular cells   

    See POU2F1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POU2F1

    SOURCE GeneReport for Unigene cluster: Hs.283402

    UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859
    Tissue specificity: Ubiquitous. Isoform 2 is lymphocyte-specific

        SABiosciences Expression via Pathway-Focused PCR Array including POU2F1: 
              Circadian Rhythms in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for POU2F1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou2f11 , 5 POU domain, class 2, transcription factor 11, 5 90.81(n)1
    93.99(a)1
      1 (73.21 cM)5
    189861  NM_198932.31  NP_945150.21 
     1658651545 
    chicken
    (Gallus gallus)
    Aves POU2F11 POU class 2 homeobox 1 90.46(n)
    96.88(a)
      396463  NM_205472.1  NP_990803.1 
    lizard
    (Anolis carolinensis)
    Reptilia POU2F16
    POU class 2 homeobox 1
    92(a)
    1 ↔ 1
    3(163498672-163661906)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.12652 Xenopus laevis Oct-1 mRNA 81.12(n)    X57165.1 
    zebrafish
    (Danio rerio)
    Actinopterygii oct12 octamer-binding transcription factor 1 75.16(n)   30715  AF030519.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nub3 neuroblast determination transcription
    factor
    75(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for POU2F1 (if available)
    TreeFam Gene Tree for POU2F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POU2F1 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F12  POU3F42  POU1F12  POU3F32  
    POU4F32  POU3F22  POU2F22  POU5F1B2  POU4F12  POU6F12  POU5F12  
    16 SIMAP similar genes for POU2F1 using alignment to 8 protein entries:     PO2F1_HUMAN (see all proteins):
    OCT6    OCT-2    POU3F1    POU6F1    POU2F3    POU2F2
    POU1F1    POU5F1P4    POU3F4    POU5F1    NKX2-5    POU3F2
    POU4F3    POU5F1B    POU5F1P1    POU3F3

    POU2F1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4063 SNPs in POU2F1 are shown (see all 4063)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358164
    A breast cancer sample4--see VAR_0358162 S F mis40--------
    rs1877466391,2
    --167188212(+) ACACAC/TACACT 3 -- us2k10--------
    rs1437566231,2
    C--167188269(+) AAAGAA/GCAAAA 3 -- us2k10--------
    rs1142291361,2
    F--167188585(+) TACCAC/AGAACA 3 -- us2k11Minor allele frequency- A:0.02NA 120
    rs14978611,2
    C,F,H--167188630(-) AAGCTA/GTTGTC 3 -- us2k19Minor allele frequency- G:0.03MN NS EA NA WA 1006
    rs1928852621,2
    C--167188644(+) CTGTAC/TTTGCA 3 -- us2k10--------
    rs1410846281,2
    --167188660(+) AAAGGA/GGTCCA 3 -- us2k10--------
    rs1848948991,2
    --167188790(+) TATCTC/GTCAAG 3 -- us2k10--------
    rs1889697171,2
    --167188886(+) AAATAA/GGGCTT 3 -- us2k10--------
    rs1501948131,2
    --167188992(+) GAAAGA/GTATGT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for POU2F1 (167190066 - 167396582 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for POU2F1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2719195CNV Deletion23290073
    nsv3421CNV Insertion18451855
    nsv3432CNV Insertion18451855
    nsv831803CNV Loss17160897
    nsv872523CNV Loss21882294
    nsv831814CNV Loss17160897
    nsv872524CNV Gain21882294
    nsv521232CNV Gain+Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164175OMIM information: 115665 116600 121800 155600 211420 600975 605225 605606 606788 606852 606928 607317 607671 608446 608543 608553 608995    
    20/40 diseases for POU2F1 (see all 40):    About MalaCards
    hereditary persistence of fetal hemoglobin    varicose veins    herpes simplex    merkel cell carcinoma
    choriocarcinoma    pituitary tumors    retinoblastoma    inflammatory bowel disease
    sjogren's syndrome    non-small cell lung carcinoma    lung cancer    chronic myeloid leukemia
    essential hypertension    kaposi's sarcoma    atherosclerosis    crohn's disease
    hodgkin's lymphoma    non-hodgkin lymphoma    rheumatoid arthritis    hypertension


    POU2F1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/19 Novoseek inferred disease relationships for POU2F1 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 53.9 14 1684335 (2), 1358755 (1), 7568211 (1), 7891704 (1) (see all 13)
    carcinoma embryonal 30.4 3 8455626 (3)
    retinoblastoma 21.6 2 7872668 (1), 10437913 (1)
    choriocarcinoma 5.03 1 16005513 (1)
    carcinoma 3.08 2 16278805 (1)
    metastasis 2.74 1 8502621 (1)
    cancer 0.97 3 10544969 (2), 19058140 (1)
    inflammatory bowel diseases 0 1 12019209 (1)
    breast carcinoma 0 1 10544969 (1)
    necrosis 0 2 17192276 (2)

    Genetic Association Database (GAD): POU2F1
    Human Genome Epidemiology (HuGE) Navigator: POU2F1 (11 documents)

    Export disorders for POU2F1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU2F1 gene, integrated from 9 sources (see all 388):
    (articles sorted by number of sources associating them with POU2F1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. (PubMed id 1684878)1, 2, 9 Segil N....Heintz N. (1991)
    2. Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1. (PubMed id 14612514)1, 2, 9 Schild-Poulter C.... Hache R.J.G. (2003)
    3. Differential phosphorylation of the transcription factor Oct1 during the cell cycle. (PubMed id 1887216)1, 3, 9 Roberts S.B....Heintz N. (1991)
    4. Human Oct-1L isoform has tissue-specific expression pattern similar to Oct-2. (PubMed id 12663137)1, 2, 9 Luchina N.N.... Pankratova E.V. (2003)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Interaction between polymorphisms in the OCT1 and MAT E1 transporter and metformin response. (PubMed id 19898263)1, 4 Becker M.L....Stricker B.H. (2010)
    7. Association of the POU class 2 homeobox 1 gene (POU2F 1) with susceptibility to Type 2 diabetes in Chinese populations. (PubMed id 21059098)1, 4 Ng M.C....Chan J.C. (2010)
    8. Molecular reclassification of Crohn's disease by clus ter analysis of genetic variants. (PubMed id 20886065)1, 4 Cleynen I....Vermeire S. (2010)
    9. Genetic Risk Profiling And Prediction Of Disease Course In Crohn'S Disease Patients. (PubMed id 19422935)1, 4 Henckaerts L....Vermeire S. (2009)
    10. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. (PubMed id 19174780)1, 4 Weersma R.K....Vermeire S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5451 HGNC: 9212 AceView: POU2F1 Ensembl:ENSG00000143190 euGenes: HUgn5451
    ECgene: POU2F1 H-InvDB: POU2F1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POU2F1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POU2F1 gene:
    Search GeneIP for patents involving POU2F1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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