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Aliases for POU2F1 Gene

Aliases for POU2F1 Gene

  • POU Class 2 Homeobox 1 2 3
  • OCT1 3 4 6
  • OTF1 3 4 6
  • Octamer-Binding Transcription Factor 1 3 4
  • Octamer-Binding Protein 1 3 4
  • Oct-1 3 4
  • NF-A1 3 4
  • OTF-1 3 4
  • POU Domain, Class 2, Transcription Factor 1 3
  • POU Domain Class 2, Transcription Factor 1 2
  • Octamer-Binding Transcription Factor-1 3
  • Oct-1B 3

External Ids for POU2F1 Gene

Previous HGNC Symbols for POU2F1 Gene

  • OTF1

Previous GeneCards Identifiers for POU2F1 Gene

  • GC01P164826
  • GC01P162840
  • GC01P163886
  • GC01P164377
  • GC01P163921
  • GC01P165456
  • GC01P138436

Summaries for POU2F1 Gene

Entrez Gene Summary for POU2F1 Gene

  • The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]

GeneCards Summary for POU2F1 Gene

POU2F1 (POU Class 2 Homeobox 1) is a Protein Coding gene. Among its related pathways are Glucocorticoid receptor regulatory network and ATF-2 transcription factor network. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is POU6F1.

UniProtKB/Swiss-Prot for POU2F1 Gene

  • Transcription factor that binds to the octamer motif (5-ATTTGCAT-3) and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.

Gene Wiki entry for POU2F1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU2F1 Gene

Genomics for POU2F1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POU2F1 Gene

Start:
167,220,829 bp from pter
End:
167,427,345 bp from pter
Size:
206,517 bases
Orientation:
Plus strand

Genomic View for POU2F1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POU2F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU2F1 Gene

Proteins for POU2F1 Gene

  • Protein details for POU2F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14859-PO2F1_HUMAN
    Recommended name:
    POU domain, class 2, transcription factor 1
    Protein Accession:
    P14859
    Secondary Accessions:
    • B1AL91
    • B1AL93
    • B4E029
    • J3KP77
    • Q5TBT7
    • Q6PK46
    • Q8NEU9
    • Q9BPV1

    Protein attributes for POU2F1 Gene

    Size:
    743 amino acids
    Molecular mass:
    76472 Da
    Quaternary structure:
    • Interacts with NR3C1, AR, PGR and HCFC1. Associates with the herpes simplex virus VP16-induced complex; binding to HCFC1 activates the viral transcriptional activator VP16 for association with POU2F1, to form a multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes.

    Three dimensional structures from OCA and Proteopedia for POU2F1 Gene

    Alternative splice isoforms for POU2F1 Gene

neXtProt entry for POU2F1 Gene

Proteomics data for POU2F1 Gene at MOPED

Post-translational modifications for POU2F1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for POU2F1 (1-Oct)

No data available for DME Specific Peptides for POU2F1 Gene

Domains for POU2F1 Gene

Gene Families for POU2F1 Gene

HGNC:
  • POU :Homeoboxes / POU class

Graphical View of Domain Structure for InterPro Entry

P14859

UniProtKB/Swiss-Prot:

PO2F1_HUMAN :
  • P14859
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 POU-specific domain.
Family:
  • Belongs to the POU transcription factor family. Class-2 subfamily.
genes like me logo Genes that share domains with POU2F1: view

Function for POU2F1 Gene

Molecular function for POU2F1 Gene

GENATLAS Biochemistry:
POU domain,class 2,transcription factor 1
UniProtKB/Swiss-Prot Function:
Transcription factor that binds to the octamer motif (5-ATTTGCAT-3) and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.

Gene Ontology (GO) - Molecular Function for POU2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 2341156
GO:0005515 protein binding IPI 10629049
GO:0043565 sequence-specific DNA binding IDA 11997177
genes like me logo Genes that share ontologies with POU2F1: view
genes like me logo Genes that share phenotypes with POU2F1: view

Animal Models for POU2F1 Gene

MGI Knock Outs for POU2F1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POU2F1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for POU2F1 Gene

Localization for POU2F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU2F1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POU2F1 Gene COMPARTMENTS Subcellular localization image for POU2F1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for POU2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11891224
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with POU2F1: view

Pathways for POU2F1 Gene

genes like me logo Genes that share pathways with POU2F1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for POU2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0010467 gene expression TAS --
GO:0030910 olfactory placode formation IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 11891224
genes like me logo Genes that share ontologies with POU2F1: view

Compounds for POU2F1 Gene

(16) Novoseek inferred chemical compound relationships for POU2F1 Gene

Compound -log(P) Hits PubMed IDs
s-napc 78.7 11
gnrh 27.2 7
diamide 23.8 2
retinoic acid 13.7 8
zinc 9.13 7
genes like me logo Genes that share compounds with POU2F1: view

Transcripts for POU2F1 Gene

Unigene Clusters for POU2F1 Gene

POU class 2 homeobox 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POU2F1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POU2F1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - - - - -
SP4: -
SP5: - - - - -
SP6:
SP7: - - - - - - - - - - - -
SP8: -
SP9: - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - -
SP12:

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24
SP1:
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7: - - -
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for POU2F1 Gene

GeneLoc Exon Structure for
POU2F1
ECgene alternative splicing isoforms for
POU2F1

Expression for POU2F1 Gene

mRNA expression in normal human tissues for POU2F1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for POU2F1 Gene

This gene is overexpressed in Stomach (22.2), Blymphocyte (10.3), Pancreas (8.1), and Skin (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POU2F1 Gene

SOURCE GeneReport for Unigene cluster for POU2F1 Gene Hs.283402

mRNA Expression by UniProt/SwissProt for POU2F1 Gene

P14859-PO2F1_HUMAN
Tissue specificity: Ubiquitous. Isoform 2 is lymphocyte-specific
genes like me logo Genes that share expressions with POU2F1: view

Expression partners for POU2F1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for POU2F1 Gene

Orthologs for POU2F1 Gene

This gene was present in the common ancestor of animals.

Orthologs for POU2F1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POU2F1 35
  • 93 (n)
  • 97.08 (a)
POU2F1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POU2F1 35
  • 91.36 (n)
  • 94.23 (a)
POU2F1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pou2f1 35
  • 90.5 (n)
  • 93.46 (a)
Pou2f1 16
Pou2f1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POU2F1 35
  • 99.64 (n)
  • 99.46 (a)
POU2F1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pou2f1 35
  • 91.34 (n)
  • 95.43 (a)
oppossum
(Monodelphis domestica)
Mammalia POU2F1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POU2F1 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves POU2F1 35
  • 88.96 (n)
  • 95.12 (a)
CHOCT-1 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POU2F1 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pou2f1 35
  • 80.84 (n)
  • 87.5 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1265 35
zebrafish
(Danio rerio)
Actinopterygii oct1 35
pou2f1b 35
  • 70.79 (n)
  • 75.93 (a)
pou2f1b 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nub 37
  • 75 (a)
pdm2 37
  • 73 (a)
nub 36
  • 22 (a)
ManyToMany
pdm2 36
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-18 36
  • 27 (a)
OneToMany
Species with no ortholog for POU2F1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POU2F1 Gene

ENSEMBL:
Gene Tree for POU2F1 (if available)
TreeFam:
Gene Tree for POU2F1 (if available)

Paralogs for POU2F1 Gene

Selected SIMAP similar genes for POU2F1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with POU2F1: view

Variants for POU2F1 Gene

Sequence variations from dbSNP and Humsavar for POU2F1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs266818 -- 167,263,573(+) CATTT(A/T)GCCTC intron-variant
rs266819 -- 167,287,553(+) AGATA(C/T)GTTTT intron-variant
rs266820 -- 167,287,231(+) ATAAC(C/T)CTTTT intron-variant
rs266821 -- 167,285,547(+) gagat(C/T)gcgcc intron-variant
rs266822 -- 167,285,408(+) GACCA(C/T)GGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POU2F1 Gene

Variant ID Type Subtype PubMed ID
nsv521232 CNV Gain+Loss 19592680
nsv3421 CNV Insertion 18451855
nsv872523 CNV Loss 21882294
nsv831803 CNV Loss 17160897
esv2719195 CNV Deletion 23290073
nsv831814 CNV Loss 17160897
nsv872524 CNV Gain 21882294
nsv3432 CNV Insertion 18451855

Relevant External Links for POU2F1 Gene

HapMap Linkage Disequilibrium report
POU2F1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU2F1 Gene

Disorders for POU2F1 Gene

(19) Novoseek inferred disease relationships for POU2F1 Gene

Disease -log(P) Hits PubMed IDs
herpes simplex 53.9 14
carcinoma embryonal 30.4 3
retinoblastoma 21.6 2
choriocarcinoma 5.03 1
carcinoma 3.08 1

Relevant External Links for POU2F1

Genetic Association Database (GAD)
POU2F1
Human Genome Epidemiology (HuGE) Navigator
POU2F1
genes like me logo Genes that share disorders with POU2F1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for POU2F1 Gene

Publications for POU2F1 Gene

  1. Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. (PMID: 1684878) Segil N. … Heintz N. (Science 1991) 3 4 23
  2. Differential phosphorylation of the transcription factor Oct1 during the cell cycle. (PMID: 1887216) Roberts S.B. … Heintz N. (Science 1991) 2 3 23
  3. Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1. (PMID: 14612514) Schild-Poulter C. … Hache R.J.G. (Cancer Res. 2003) 3 4 23
  4. STAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression. (PMID: 14645506) MagnAc S. … Dusanter-Fourt I. (Mol. Cell. Biol. 2003) 3 23
  5. Regulation of basal and induced expression of C-reactive protein through an overlapping element for OCT-1 and NF-kappaB on the proximal promoter. (PMID: 16116232) Voleti B. … Agrawal A. (J. Immunol. 2005) 3 23

Products for POU2F1 Gene

Sources for POU2F1 Gene

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