Aliases
for POU2F1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 4
| Aliases |
|---|
| POU Class 2 Homeobox 11 2 | | POU Domain Class 2, Transcription Factor 11 | | OCT11 2 3 5 | | Oct-13 | | OTF11 2 3 5 | | Oct-1B1 | | Octamer-Binding Protein 12 3 | | Octamer-Binding Transcription Factor-12 | | Octamer-Binding Transcription Factor 12 3 | | POU Domain, Class 2, Transcription Factor 12 | | NF-A12 3 | | Oct-13 | | OTF-12 3 | | |
| External Ids: | HGNC: 92121 | Entrez Gene: 54512 | Ensembl: ENSG000001431907 | OMIM: 1641755 | UniProtKB: P148593 |
|---|
|
Export aliases for POU2F1 gene to outside databasesPrevious GC identifers: GC01P164826 GC01P162840 GC01P163886 GC01P164377 GC01P163921 GC01P165456 GC01P138436
Summaries
for POU2F1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for POU2F1:
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarizedby Sturm et al., 1993 (PubMed 8314572)). Members of this family contain the POU domain, a 160-amino acid regionnecessary for DNA binding to the octameric sequence ATGCAAAT.(supplied by OMIM, Jul 2010)
UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of thegenes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulatestranscription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV)infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 therebyenabling the transcription of the viral immediate early genes
Gene Wiki entry for POU2F1
fRNAdb sequence ontology for POU2F1:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.
View fRNAdb secondary structures for POU2F1 |
Genomic Views
for POU2F1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the POU2F1 gene promoter:
SRF AP-2alpha isoform 3 SRF (504 AA) Nkx2-5 STAT5A AP-2alpha isoform 2 AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for POU2F1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU2F1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q24.2 Ensembl cytogenetic band: 1q24.1 HGNC cytogenetic band: 1q24.2POU2F1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P167190: view genomic region
(about GC identifiers)
Start:
|
167,190,066 bp from pter |
End:
|
167,396,582 bp from pter |
Size:
|
206,517 bases |
Orientation:
|
plus strand |
ORGUL member locations:
Legend (see complete legend)
- n410211
- FR0346925
- n345471
- n338347
167190122 167314945 167439768 chr1
|
Proteins
for POU2F1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859 (See
protein sequence)Recommended Name: POU domain, class 2, transcription factor 1 Size: 743 amino acids; 76472 Da
Subunit: Interacts with NR3C1, AR, PGR and HCFC1. Associates with the herpes simplex virus VP16-induced complex;binding to HCFC1 activates the viral transcriptional activator VP16 for association with POU2F1, to form amultiprotein-DNA complex responsible for activating transcription of the viral immediate early genes
Subcellular location: Nucleus
6/8 PDB 3D structures from  and Proteopedia  for POU2F1 (see all 8):1CQT (3D)
1E3O (3D)
1GT0 (3D)
1HF0 (3D)
1O4X (3D)
1OCT (3D)
Secondary accessions: B1AL91 B1AL93 B4E029 Q5TBT7 Q6PK46 Q8NEU9 Q9BPV1Alternative splicing: 5 isoforms: P14859-1 P14859-2 P14859-3 P14859-4 P14859-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for POU2F1: NX_P14859
Post-translational modifications:
Phosphorylated by PRKDC1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P14859
POU2F1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001185712.1 NP_001185715.1 NP_002688.3
ENSEMBL proteins: ENSP00000356840 ENSP00000452912 ENSP00000452761 ENSP00000453135 ENSP00000404571 ENSP00000391523 ENSP00000401217 ENSP00000444625 ENSP00000356839 ENSP00000271411 ENSP00000356836 ENSP00000453094 ENSP00000441285 ENSP00000415993 ENSP00000414660 Reactome Protein details: P14859
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
POU2F1 for ontologies About GeneDecksing
POU2F1 Antibody Products:
Assay Products for POU2F1: |
Protein
Domains /
Families
for POU2F1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
POU2F1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P14859ProtoNet protein and cluster: P14859 3 Blocks protein families: IPB000327 POU domain IPB000972 Octamer-binding transcription factor signature IPB013847 POU
UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859Similarity: Belongs to the POU transcription factor family. Class-2 subfamilySimilarity: Contains 1 homeobox DNA-binding domainSimilarity: Contains 1 POU-specific domain |
Function
for POU2F1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of thegenes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulatestranscription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV)infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 therebyenabling the transcription of the viral immediate early genes Genatlas biochemistry entry for POU2F1:POU domain,class 2,transcription factor 1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POU2F1 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POU2F1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): POU2F1 (NM_001198783) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POU2F1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU2F1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
POU2F1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for POU2F1:
Animal Models:
Mouse knock-outs for POU2F1: Pou2f1tm1Cav Cd247/Pou2f1Cd247/tm1Tks
13 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Pou2f1):
POU2F1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for POU2F1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RNA Polymerase III Transcription Initiation | | | 2 | Calcium signaling in the CD4+ TCR pathway | | | 3 | Immune response_IL-2 activation and signaling pathway | | | 4 | Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) | | | 5 | Transcription | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for POU2F1
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POU2F1
2  GeneGo (Thomson Reuters) Pathways for POU2F1
5/6  BioSystems Pathways for POU2F1 (see all 6)
5/7 
Reactome Pathways for POU2F1 (see all 7)
POU2F1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU2F1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/95 Interacting proteins for POU2F1 (P148591, 2, 3 ENSP000002714114) via UniProtKB, MINT, STRING, and/or I2D (see all 95)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006383 | transcription from RNA polymerase III promoter |
TAS | -- | | GO:0010467 | gene expression |
TAS | -- | | GO:0030910 | olfactory placode formation |
-- | -- | | GO:0045892 | negative regulation of transcription, DNA-dependent |
IDA | 11891224 |
POU2F1 for ontologies About GeneDecksing
|
Drugs & Compounds
for POU2F1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
POU2F1 for compounds About GeneDecksing
 Browse Tocris compounds for POU2F1
10/16 Novoseek chemical compound relationships for POU2F1 gene (see all 16) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| s-napc |
78.7 |
15 |
9188510 (4), 11463379 (3), 9832505 (2), 9418884 (2) |
| gnrh |
27.2 |
8 |
12188930 (2), 16002402 (2), 15319450 (2), 10674395 (1) |
| diamide |
23.8 |
2 |
9115711 (1), 9489510 (1) |
| retinoic acid |
13.7 |
9 |
7646519 (4), 8455626 (3), 14993281 (1) |
| zinc |
9.13 |
8 |
10455183 (3), 9111349 (1), 7568211 (1), 14669980 (1) (see all 5) |
| glyceraldehyde 3-phosphate |
8.59 |
5 |
12887926 (1), 18682386 (1), 16301215 (1) |
| oligonucleotide |
6.28 |
5 |
8026890 (1), 9518258 (1), 14729276 (1) |
| calcium |
1.5 |
1 |
8964085 (1) |
| nitric oxide |
0 |
16 |
9489510 (6), 19467240 (1), 10674395 (1) |
| cyclic amp |
0 |
2 |
15336700 (1), 14993281 (1) |
Search CenterWatch for drugs/clinical trials and news about POU2F1 / PO2F1
|
Transcripts
for POU2F1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
| 1 fRNAdb Secondary structure:
REFSEQ mRNAs for POU2F1 gene (3 alternative transcripts): NM_001198783.1 NM_001198786.1 NM_002697.3 Unigene Cluster for POU2F1: POU class 2 homeobox 1 Hs.283402 [show with all ESTs]Unigene Representative Sequence: NM_00119878318/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000367866(uc001geg.3 uc001gee.3 uc010plh.2) ENST00000559038
ENST00000557909 ENST00000558944 ENST00000442313 ENST00000452019 ENST00000429375
ENST00000492850 ENST00000367865(uc001ged.3) ENST00000271411(uc010plg.2 uc001gec.3)
ENST00000367862(uc001gef.3) ENST00000560232 ENST00000557874 ENST00000541643
ENST00000470928 ENST00000443275(uc009wvg.1) ENST00000490100 ENST00000559648
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POU2F1 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POU2F1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): POU2F1 (NM_001198783) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POU2F1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU2F1 |
Additional cDNA sequence: AK091438.1 AK124826.1 AK303201.1 AK308004.1 AY113189.1 BC001664.2 BC003571.1 BC007388.2 BC037864.2 BC052274.1 CR627124.1 NR_037163.1 S66901.1 X13403.1 22 DOTS entries: DT.95140199 DT.95171994 DT.312945 DT.100788108 DT.101983687 DT.92434662 DT.203889 DT.309153 DT.100788111 DT.121436911 DT.100808918 DT.121436837 DT.100026449 DT.121436891 DT.437142 DT.91839750 DT.95171990 DT.95348533 DT.99934717 DT.100739535 DT.86848723 DT.92021422 24/145 AceView cDNA sequences (see all 145): BC003571 BP339121 BE396853 BQ928677 BC041822 BQ068393 BM694716 BC001664 BQ938715 S66902 BQ962465 BM782895 BQ213592 BE269179 BG388369 BM040945 BC052274 S66901 BM452501 NM_002697 AU122313 BG752224 BE385281 AU124383
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for POU2F1 (see all 12) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | - | | - | | | | | | | | | |
| ExUns: | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for POU2F1
|
Expression
for POU2F1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| POU2F1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTGGAGAA
About this image
See POU2F1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POU2F1
SOURCE GeneReport for Unigene cluster: Hs.283402
UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859Tissue specificity: Ubiquitous. Isoform 2 is lymphocyte-specific
SABiosciences Expression via Pathway-Focused PCR Array including POU2F1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POU2F1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POU2F1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU2F1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU2F1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F1 |
Orthologs
for POU2F1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for POU2F1 gene from 6/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
POU2F11 |
POU class 2 homeobox 1 |
90.46(n)
96.88(a) |
|
396463 NM_205472.1 NP_990803.1 |
lizard
(Anolis carolinensis) |
Reptilia |
POU2F16 |
-- |
91(a) |
1 ↔ 1 |
3(163602982-163661906) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.12652 |
Xenopus laevis Oct-1 mRNA |
81.12(n) |
|
X57165.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
oct12 |
octamer-binding transcription factor 1 |
75.16(n) |
|
30715 AF030519.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
nub3 |
neuroblast determination transcription
factor |
75(a)
(best of 2) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
ceh-186 |
Homeobox protein ceh-18 |
21(a) |
1 → many |
X(3843808-3857778) |
ENSEMBL Gene Tree for POU2F1 (if available)
TreeFam Gene Tree for POU2F1 (if available) |
Paralogs
for POU2F1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for POU2F1 gene
- POU5F22 POU6F22 POU4F22 POU2F32 POU3F42 POU3F12 POU1F12 POU4F32
- POU3F32 POU3F22 POU2F22 POU5F1B2 POU4F12 POU5F12 POU6F12
16 SIMAP similar genes for POU2F1 using alignment to 8 protein entries: PO2F1_HUMAN (see all proteins):OCT6 OCT-2 POU3F1 POU6F1 POU2F3 POU2F2
POU1F1 POU5F1P4 POU3F4 POU5F1 NKX2-5 POU3F2
POU4F3 POU5F1B POU5F1P1 POU3F3
POU2F1 for paralogs About GeneDecksing
|
Genomic Variants
for POU2F1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for POU2F1 (167190066 - 167396582 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for POU2F1
2 CNVs: 34731 84641
1 Indel: 74769 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POU2F1 |
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Disorders
/ Diseases
for POU2F1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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POU2F1 for disorders About GeneDecksing
OMIM gene information: 164175 115665 116600 121800 155600 211420 600975 605225 605606 606788 606852 606928 607317 607671 608446 608543 608553 608995
20/45  diseases for POU2F1 (see all 45): About MalaCardshereditary persistence of fetal hemoglobin non-small cell lung carcinoma non-hodgkin lymphoma inflammatory bowel disease
herpes simplex merkel cell carcinoma hodgkin's lymphoma rheumatoid arthritis
chronic myeloid leukemia myeloid leukemia kaposi's sarcoma essential hypertension
lung cancer susceptibility sjogren's syndrome choriocarcinoma pituitary tumor
embryonal carcinoma lung carcinoma retinoblastoma crohn's disease
10/19 Novoseek disease relationships for POU2F1 gene (see all 19) About this table
Genetic Association Database (GAD): POU2F1
Human Genome Epidemiology (HuGE) Navigator: POU2F1 (11 documents)
Export disorders for POU2F1 gene to outside databases
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Publications
for POU2F1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for POU2F1 gene, integrated from 9 sources (see all 380):
(articles sorted by number of sources associating them with POU2F1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. (PubMed id 1684878)1, 2, 9 Segil N....Heintz N. (1991)
- Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1. (PubMed id 14612514)1, 2, 9 Schild-Poulter C.... Hache R.J.G. (2003)
- Differential phosphorylation of the transcription factor Oct1 during the cell cycle. (PubMed id 1887216)1, 3, 9 Roberts S.B....Heintz N. (1991)
- Human Oct-1L isoform has tissue-specific expression pattern similar to Oct-2. (PubMed id 12663137)1, 2, 9 Luchina N.N.... Pankratova E.V. (2003)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Identification of hippocampus-related candidate genes for Alzheimer's disease. (PubMed id 15786443)1, 4 Taguchi K....Miki T. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP. (PubMed id 10629049)1, 2 Mahajan S.S. and Wilson A.C. (2000)
- Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter. (PubMed id 10480874)1, 2 Prefontaine G.G....Hache R.J.G. (1999)
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External Searches for POU2F1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing POU2F1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing POU2F1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing POU2F1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for POU2F1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for POU2F1 gene:
Search GeneIP for patents involving POU2F1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for POU2F1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for POU2F1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POU2F1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POU2F1 | | | OriGene Protein Over-expression Lysate for |
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