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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU2F1 Gene

protein-coding   GIFtS: 64
GCID: GC01P167190

POU class 2 homeobox 1

(Previous names: POU domain class 2, transcription factor 1 )
(Previous symbol: OTF1)
 Explore 45 diseases affiliated with
POU2F1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for POU2F1    

Aliases
for POU2F1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
POU Class 2 Homeobox 11 2     POU Domain Class 2, Transcription Factor 11
OCT11 2 3 5     Oct-13
OTF11 2 3 5     Oct-1B1
Octamer-Binding Protein 12 3     Octamer-Binding Transcription Factor-12
Octamer-Binding Transcription Factor 12 3     POU Domain, Class 2, Transcription Factor 12
NF-A12 3     Oct-13
OTF-12 3     

External Ids:    HGNC: 92121   Entrez Gene: 54512   Ensembl: ENSG000001431907   OMIM: 1641755   UniProtKB: P148593   
ORGUL members:    fRNAdb10:FR346925      
H-InvDB:HIT000216140    
NCBI:S66902    
NONCODE:n410211 n338347 n345471    
RNAdb:HIV1154    

Export aliases for POU2F1 gene to outside databases

Previous GC identifers: GC01P164826 GC01P162840 GC01P163886 GC01P164377 GC01P163921 GC01P165456 GC01P138436


Summaries
for POU2F1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for POU2F1:
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized
by Sturm et al., 1993 (PubMed 8314572)). Members of this family contain the POU domain, a 160-amino acid region
necessary for DNA binding to the octameric sequence ATGCAAAT.(supplied by OMIM, Jul 2010)

UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the
genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates
transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV)
infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby
enabling the transcription of the viral immediate early genes

Gene Wiki entry for POU2F1

fRNAdb sequence ontology for POU2F1:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for POU2F1

Genomic Views
for POU2F1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU2F1 gene promoter:
         SRF   AP-2alpha isoform 3   SRF (504 AA)   Nkx2-5   STAT5A   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POU2F1 promoter sequence
   Search SABiosciences Chromatin IP Primers for POU2F1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU2F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.2   Ensembl cytogenetic band:  1q24.1   HGNC cytogenetic band: 1q24.2

POU2F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU2F1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P167190:  view genomic region     (about GC identifiers)

Start:
 167,190,066 bp from pter      End:
 167,396,582 bp from pter
Size:
 206,517 bases      Orientation:
 plus strand
ORGUL member locations:
Legend (see complete legend)

  • n410211
  • FR0346925
  • n345471
  • n338347
167190122 167314945 167439768 chr1

Proteins
for POU2F1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859 (See protein sequence)
Recommended Name: POU domain, class 2, transcription factor 1  
Size: 743 amino acids; 76472 Da
Subunit: Interacts with NR3C1, AR, PGR and HCFC1. Associates with the herpes simplex virus VP16-induced complex;
binding to HCFC1 activates the viral transcriptional activator VP16 for association with POU2F1, to form a
multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes
Subcellular location: Nucleus
6/8 PDB 3D structures from and Proteopedia for POU2F1 (see all 8):
1CQT (3D)        1E3O (3D)        1GT0 (3D)        1HF0 (3D)        1O4X (3D)        1OCT (3D)    
Secondary accessions: B1AL91 B1AL93 B4E029 Q5TBT7 Q6PK46 Q8NEU9 Q9BPV1
Alternative splicing: 5 isoforms:  P14859-1   P14859-2   P14859-3   P14859-4   P14859-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for POU2F1: NX_P14859

Post-translational modifications:

  • Phosphorylated by PRKDC1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P14859

    • POU2F1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001185712.1  NP_001185715.1  NP_002688.3  

    ENSEMBL proteins: 
     ENSP00000356840   ENSP00000452912   ENSP00000452761   ENSP00000453135   ENSP00000404571  
     ENSP00000391523   ENSP00000401217   ENSP00000444625   ENSP00000356839   ENSP00000271411  
     ENSP00000356836   ENSP00000453094   ENSP00000441285   ENSP00000415993   ENSP00000414660  
    Reactome Protein details: P14859
    Human Recombinant Protein Products: 
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    Novus Biologicals POU2F1 Protein
    Novus Biologicals POU2F1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11891224
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex ----


    POU2F1 for ontologies           About GeneDecksing



    POU2F1 Antibody Products: 
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    ThermoFisher Antibodies for POU2F1

    Assay Products for POU2F1: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for POU2F1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    POU2F1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR000972 TF_octamer
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS

    Graphical View of Domain Structure for InterPro Entry P14859

    ProtoNet protein and cluster: P14859

    3 Blocks protein families:
    IPB000327 POU domain
    IPB000972 Octamer-binding transcription factor signature
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859
    Similarity: Belongs to the POU transcription factor family. Class-2 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    Function
    for POU2F1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859
    Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the
    genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates
    transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV)
    infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby
    enabling the transcription of the viral immediate early genes

         Genatlas biochemistry entry for POU2F1:
    POU domain,class 2,transcription factor 1

    10/2681 SABiosciences Target genes for POU2F1 (see all 2681):
    A1CF A4GNT AAA1 AADAC AARS2 AASDH AASDHPPT AATK ABCA13 ABCB4

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU2F1
    8/277 QIAGEN miScript miRNA Assays for microRNAs that regulate POU2F1 (see all 277):
    hsa-miR-579 hsa-miR-605 hsa-miR-1273d hsa-miR-3622b-3p hsa-miR-761 hsa-miR-520b hsa-miR-3690 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmid: POU2F1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POU2F1 (see all 4)
    OriGene shRNA RFP: POU2F1
    OriGene siRNA: POU2F1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU2F1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for POU2F1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POU2F1 (see all 7) (see first 1)
    NM_001198783 (human cat#: RC230873)  NM_001198786 (human cat#: RC231382)  NM_002697 (human cat#: RC208599)  
    NM_011137 (mouse cat#: MR223763)  NM_198932 (mouse cat#: MR224186)  
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    Cell Line
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    Search LifeMap BioReagents cell lines for POU2F1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10976766
    GO:0043565sequence-specific DNA binding IDA9242494


    POU2F1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for POU2F1:
     Increased cell number in S and 

    Animal Models:
         Mouse knock-outs for POU2F1: Pou2f1tm1Cav Cd247/Pou2f1Cd247/tm1Tks
         13 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Pou2f1):
     behavior/neurological  craniofacial  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  integument  liver/biliary system  mortality/aging  nervous system 
     respiratory system  taste/olfaction  vision/eye 

    POU2F1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for POU2F1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RNA Polymerase III Transcription Initiation
    		RNA Polymerase III Abortive And Retractive Initiation1.00
    		RNA Polymerase III Transcription Initiation From Type 3 Promoter0.80
    		RNA Polymerase III Transcription Initiation1.00
    		RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.59
    		RNA Polymerase III Transcription1.00
    2Calcium signaling in the CD4+ TCR pathway
    		Calcium signaling in the CD4+ TCR pathway1.00
    		Calcineurin-regulated NFAT-dependent transcription in lymphocytes0.38
    3Immune response_IL-2 activation and signaling pathway
    		Immune response IL-3 activation and signaling pathway0.41
    		Immune response_IL-3 activation and signaling pathway0.41
    4Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    		Development Glucocorticoid receptor signaling0.27
    		Development_Glucocorticoid receptor signaling0.27
    5Transcription
    		Transcription1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for POU2F1
        Development Glucocorticoid receptor signaling
    Immune response IL-3 activation and signaling pathway

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POU2F1
        BRCA1 Pathway
    Glucocorticoid Receptor Signaling
    PKC-Theta Pathway

    2 GeneGo (Thomson Reuters) Pathways for POU2F1
        Immune response IL-3 activation and signaling pathway
    Development Glucocorticoid receptor signaling

    5/6 BioSystems Pathways for POU2F1 (see all 6) 
        Regulation of Androgen receptor activity
    FOXA1 transcription factor network
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    Calcium signaling in the CD4+ TCR pathway
    Glucocorticoid receptor regulatory network

    5/7        Reactome Pathways for POU2F1 (see all 7)
        RNA Polymerase III Transcription Initiation
    RNA Polymerase III Transcription Initiation From Type 3 Promoter
    Transcription
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
    RNA Polymerase III Transcription



    POU2F1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU2F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/95 Interacting proteins for POU2F1 (P148591, 2, 3 ENSP000002714114) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TEAD1P283472, 3, ENSP000003545884MINT-73316 I2D: score=1 STRING: ENSP00000354588
    SP1P080471, 2, 3, ENSP000003293574EBI-624770,EBI-298336 MINT-6803426 MINT-6803452 MINT-6803484 MINT-6803438 MINT-6803470 I2D: score=4 STRING: ENSP00000329357
    BRCA1P383983, ENSP000003502834I2D: score=3 STRING: ENSP00000350283
    HCFC1P516103, ENSP000003095554I2D: score=3 STRING: ENSP00000309555
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006383transcription from RNA polymerase III promoter TAS--
    GO:0010467gene expression TAS--
    GO:0030910olfactory placode formation ----
    GO:0045892negative regulation of transcription, DNA-dependent IDA11891224


    POU2F1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for POU2F1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POU2F1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for POU2F1
    10/16 Novoseek chemical compound relationships for POU2F1 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-napc 78.7 15 9188510 (4), 11463379 (3), 9832505 (2), 9418884 (2)
    gnrh 27.2 8 12188930 (2), 16002402 (2), 15319450 (2), 10674395 (1)
    diamide 23.8 2 9115711 (1), 9489510 (1)
    retinoic acid 13.7 9 7646519 (4), 8455626 (3), 14993281 (1)
    zinc 9.13 8 10455183 (3), 9111349 (1), 7568211 (1), 14669980 (1) (see all 5)
    glyceraldehyde 3-phosphate 8.59 5 12887926 (1), 18682386 (1), 16301215 (1)
    oligonucleotide 6.28 5 8026890 (1), 9518258 (1), 14729276 (1)
    calcium 1.5 1 8964085 (1)
    nitric oxide 0 16 9489510 (6), 19467240 (1), 10674395 (1)
    cyclic amp 0 2 15336700 (1), 14993281 (1)

    Search CenterWatch for drugs/clinical trials and news about POU2F1 / PO2F1 

    Transcripts
    for POU2F1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    		 1 fRNAdb Secondary structure:


    REFSEQ mRNAs for POU2F1 gene (3 alternative transcripts): 
    NM_001198783.1  NM_001198786.1  NM_002697.3  

    Unigene Cluster for POU2F1:

    POU class 2 homeobox 1
    Hs.283402  [show with all ESTs]
    Unigene Representative Sequence: NM_001198783
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000367866(uc001geg.3 uc001gee.3 uc010plh.2) ENST00000559038
    ENST00000557909 ENST00000558944 ENST00000442313 ENST00000452019 ENST00000429375
    ENST00000492850 ENST00000367865(uc001ged.3) ENST00000271411(uc010plg.2 uc001gec.3)
    ENST00000367862(uc001gef.3) ENST00000560232 ENST00000557874 ENST00000541643
    ENST00000470928 ENST00000443275(uc009wvg.1) ENST00000490100 ENST00000559648


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    8/277 QIAGEN miScript miRNA Assays for microRNAs that regulate POU2F1 (see all 277):
    hsa-miR-579 hsa-miR-605 hsa-miR-1273d hsa-miR-3622b-3p hsa-miR-761 hsa-miR-520b hsa-miR-3690 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmid: POU2F1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POU2F1 (see all 4)
    OriGene shRNA RFP: POU2F1
    OriGene siRNA: POU2F1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU2F1
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK091438.1 AK124826.1 AK303201.1 AK308004.1 AY113189.1 BC001664.2 BC003571.1 BC007388.2 
    BC037864.2 BC052274.1 CR627124.1 NR_037163.1 S66901.1 X13403.1 

    22 DOTS entries:

    DT.95140199  DT.95171994  DT.312945  DT.100788108  DT.101983687  DT.92434662  DT.203889  DT.309153 
    DT.100788111  DT.121436911  DT.100808918  DT.121436837  DT.100026449  DT.121436891  DT.437142  DT.91839750 
    DT.95171990  DT.95348533  DT.99934717  DT.100739535  DT.86848723  DT.92021422 

    24/145 AceView cDNA sequences (see all 145):

    BC003571 BP339121 BE396853 BQ928677 BC041822 BQ068393 BM694716 BC001664 
    BQ938715 S66902 BQ962465 BM782895 BQ213592 BE269179 BG388369 BM040945 
    BC052274 S66901 BM452501 NM_002697 AU122313 BG752224 BE385281 AU124383 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for POU2F1 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
    SP1:                          -           -     -     -           -     -     -                                                     -                           
    SP2:                                                              -     -     -                                                     -                           
    SP3:                          -     -     -     -     -           -     -     -                                                     -                           
    SP4:                                                                                                                                -                           
    SP5:                                                              -     -     -                                               -     -                           

    ExUns: 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                            -     -         
    SP5:                                                            


    ECgene alternative splicing isoforms for POU2F1

    Expression
    for POU2F1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU2F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATTGGAGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See POU2F1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POU2F1

    SOURCE GeneReport for Unigene cluster: Hs.283402

    UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859
    Tissue specificity: Ubiquitous. Isoform 2 is lymphocyte-specific

        SABiosciences Expression via Pathway-Focused PCR Array including POU2F1: 
              Circadian Rhythms in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for POU2F1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for POU2F1 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves POU2F11 POU class 2 homeobox 1 90.46(n)
    96.88(a)    		   396463  NM_205472.1  NP_990803.1 
    lizard
    (Anolis carolinensis)    		 Reptilia POU2F16
    		 --
    		 91(a)
    		 1 ↔ 1
    		 3(163602982-163661906)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.12652 Xenopus laevis Oct-1 mRNA 81.12(n)    X57165.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii oct12 octamer-binding transcription factor 1 75.16(n)   30715  AF030519.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta nub3 neuroblast determination transcription
    factor    		 75(a)
    (best of 2)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea ceh-186
    		 Homeobox protein ceh-18
    		 21(a)
    		 1 → many
    		 X(3843808-3857778)


    ENSEMBL Gene Tree for POU2F1 (if available)
    TreeFam Gene Tree for POU2F1 (if available) 

    Paralogs
    for POU2F1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POU2F1 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F42  POU3F12  POU1F12  POU4F32  
    POU3F32  POU3F22  POU2F22  POU5F1B2  POU4F12  POU5F12  POU6F12  
    16 SIMAP similar genes for POU2F1 using alignment to 8 protein entries:     PO2F1_HUMAN (see all proteins):
    OCT6    OCT-2    POU3F1    POU6F1    POU2F3    POU2F2
    POU1F1    POU5F1P4    POU3F4    POU5F1    NKX2-5    POU3F2
    POU4F3    POU5F1B    POU5F1P1    POU3F3

    POU2F1 for paralogs           About GeneDecksing



    Genomic Variants
    for POU2F1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3343 NCBI SNPs in POU2F1 are shown (see all 3343)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs356172531,2
    		C,--138599368(+) TTTAA-/TTTTTT 1 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs1877466391,2
    		--167188212(+) ACACAC/TACACT 3 -- us2k10--------
    rs1437566231,2
    		--167188269(+) AAAGAA/GCAAAA 3 -- us2k10--------
    rs1142291361,2
    		F,--167188585(+) TACCAC/AGAACA 3 -- us2k11Minor allele frequency- A:0.02NA 120
    rs14978611,2
    		C,F,H,--167188630(-) AAGCTA/GTTGTC 3 -- us2k19Minor allele frequency- G:0.03MN NS EA NA WA 1006
    rs1928852621,2
    		--167188644(+) CTGTAC/TTTGCA 3 -- us2k10--------
    rs1410846281,2
    		--167188660(+) AAAGGA/GGTCCA 3 -- us2k10--------
    rs1848948991,2
    		--167188790(+) TATCTC/GTCAAG 3 -- us2k10--------
    rs1889697171,2
    		--167188886(+) AAATAA/GGGCTT 3 -- us2k10--------
    rs1501948131,2
    		--167188992(+) GAAAGA/GTATGT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for POU2F1 (167190066 - 167396582 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for POU2F1
         2 CNVs: 34731 84641
         1 Indel: 74769

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    Disorders / Diseases
    for POU2F1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    POU2F1 for disorders           About GeneDecksing

    OMIM gene information: 164175 115665 116600 121800 155600 211420 600975 605225 605606 606788 606852 606928 607317 607671 608446 608543 608553 608995    
    20/45 diseases for POU2F1 (see all 45):    About MalaCards
    hereditary persistence of fetal hemoglobin    non-small cell lung carcinoma    non-hodgkin lymphoma    inflammatory bowel disease
    herpes simplex    merkel cell carcinoma    hodgkin's lymphoma    rheumatoid arthritis
    chronic myeloid leukemia    myeloid leukemia    kaposi's sarcoma    essential hypertension
    lung cancer susceptibility    sjogren's syndrome    choriocarcinoma    pituitary tumor
    embryonal carcinoma    lung carcinoma    retinoblastoma    crohn's disease

    10/19 Novoseek disease relationships for POU2F1 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 53.9 14 1684335 (2), 1358755 (1), 7568211 (1), 7891704 (1) (see all 13)
    carcinoma embryonal 30.4 3 8455626 (3)
    retinoblastoma 21.6 2 7872668 (1), 10437913 (1)
    choriocarcinoma 5.03 1 16005513 (1)
    carcinoma 3.08 2 16278805 (1)
    metastasis 2.74 1 8502621 (1)
    cancer 0.97 3 10544969 (2), 19058140 (1)
    inflammatory bowel diseases 0 1 12019209 (1)
    breast carcinoma 0 1 10544969 (1)
    necrosis 0 2 17192276 (2)

    Genetic Association Database (GAD): POU2F1
    Human Genome Epidemiology (HuGE) Navigator: POU2F1 (11 documents)

    Export disorders for POU2F1 gene to outside databases

    Publications
    for POU2F1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU2F1 gene, integrated from 9 sources (see all 380):
    (articles sorted by number of sources associating them with POU2F1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. (PubMed id 1684878)1, 2, 9 Segil N....Heintz N. (1991)
    2. Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1. (PubMed id 14612514)1, 2, 9 Schild-Poulter C.... Hache R.J.G. (2003)
    3. Differential phosphorylation of the transcription factor Oct1 during the cell cycle. (PubMed id 1887216)1, 3, 9 Roberts S.B....Heintz N. (1991)
    4. Human Oct-1L isoform has tissue-specific expression pattern similar to Oct-2. (PubMed id 12663137)1, 2, 9 Luchina N.N.... Pankratova E.V. (2003)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. Identification of hippocampus-related candidate genes for Alzheimer's disease. (PubMed id 15786443)1, 4 Taguchi K....Miki T. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP. (PubMed id 10629049)1, 2 Mahajan S.S. and Wilson A.C. (2000)
    10. Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter. (PubMed id 10480874)1, 2 Prefontaine G.G....Hache R.J.G. (1999)

    External Searches for POU2F1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing POU2F1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5451 HGNC: 9212 AceView: POU2F1 Ensembl:ENSG00000143190 euGenes: HUgn5451
    ECgene: POU2F1 H-InvDB: POU2F1

    Other Databases showing POU2F1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing POU2F1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POU2F1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for POU2F1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for POU2F1 gene:
    Search GeneIP for patents involving POU2F1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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