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POU2F1 Gene

protein-coding   GIFtS: 66
GCID: GC01P167190

POU Class 2 Homeobox 1

(Previous names: POU domain class 2, transcription factor 1)
(Previous symbol: OTF1)
  See POU2F1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
POU Class 2 Homeobox 11 2     POU Domain Class 2, Transcription Factor 11
OTF11 2 3 5     oct-12
OCT12 3 5     oct-1B2
Octamer-Binding Protein 12 3     Octamer-Binding Transcription Factor-12
Octamer-Binding Transcription Factor 12 3     POU Domain, Class 2, Transcription Factor 12
NF-A12 3     Oct-13
OTF-12 3     

External Ids:    HGNC: 92121   Entrez Gene: 54512   Ensembl: ENSG000001431907   OMIM: 1641755   UniProtKB: P148593   

Export aliases for POU2F1 gene to outside databases

Previous GC identifers: GC01P164826 GC01P162840 GC01P163886 GC01P164377 GC01P163921 GC01P165456 GC01P138436


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POU2F1 Gene:
The OCT1 transcription factor was among the first identified members of the POU transcription factor family
(summarized by Sturm et al., 1993 (PubMed 8314572)). Members of this family contain the POU domain, a 160-amino
acid region necessary for DNA binding to the octameric sequence ATGCAAAT.(supplied by OMIM, Jul 2010)

GeneCards Summary for POU2F1 Gene:
POU2F1 (POU class 2 homeobox 1) is a protein-coding gene. Diseases associated with POU2F1 include hereditary persistence of fetal hemoglobin. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the
genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins.
Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex
virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and
HCFC1 thereby enabling the transcription of the viral immediate early genes

Gene Wiki entry for POU2F1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the POU2F1 gene promoter:
         SRF   AP-2alpha isoform 3   SRF (504 AA)   Nkx2-5   STAT5A   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOU2F1 promoter sequence
   Search Chromatin IP Primers for POU2F1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU2F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.2   Ensembl cytogenetic band:  1q24.1   HGNC cytogenetic band: 1q24.2

POU2F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU2F1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P167190:  view genomic region     (about GC identifiers)

Start:
167,190,066 bp from pter      End:
167,396,582 bp from pter
Size:
206,517 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for POU2F1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859 (See protein sequence)
Recommended Name: POU domain, class 2, transcription factor 1  
Size: 743 amino acids; 76472 Da
Subunit: Interacts with NR3C1, AR, PGR and HCFC1. Associates with the herpes simplex virus VP16-induced complex;
binding to HCFC1 activates the viral transcriptional activator VP16 for association with POU2F1, to form a
multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes
Selected PDB 3D structures from and Proteopedia for POU2F1 (see all 8):
1CQT (3D)        1E3O (3D)        1GT0 (3D)        1HF0 (3D)        1O4X (3D)        1OCT (3D)    
Secondary accessions: B1AL91 B1AL93 B4E029 Q5TBT7 Q6PK46 Q8NEU9 Q9BPV1
Alternative splicing: 5 isoforms:  P14859-1   P14859-2   P14859-3   P14859-4   P14859-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for POU2F1: NX_P14859

Explore proteomics data for POU2F1 at MOPED

Post-translational modifications: 

  • Phosphorylated by PRKDC1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POU2F1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001185712.1  NP_001185715.1  NP_002688.3  

    ENSEMBL proteins: 
     ENSP00000356840   ENSP00000404571   ENSP00000453094   ENSP00000401217   ENSP00000271411  
     ENSP00000356836   ENSP00000415993   ENSP00000414660   ENSP00000441285   ENSP00000391523  
    Reactome Protein details: P14859

    POU2F1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for POU2F1
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    OriGene MassSpec for POU2F1
    OriGene Custom Protein Services for POU2F1
    GenScript Custom Purified and Recombinant Proteins Services for POU2F1
    Novus Biologicals POU2F1 Protein
    Novus Biologicals POU2F1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for POU2F1 

    POU2F1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of POU2F1
    R&D Systems Antibodies for POU2F1 (1-Oct)
    Cell Signaling Technology (CST) Antibodies for POU2F1  (1-Oct)
    OriGene Antibodies for POU2F1
    OriGene Custom Antibody Services for POU2F1
    Novus Biologicals POU2F1 Antibodies
    Abcam antibodies for POU2F1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for POU2F1
    LSBio Antibodies in human, mouse, rat for POU2F1

    POU2F1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POU2F1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for POU2F1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POU: Homeoboxes / POU class

    Selected InterPro protein domains (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR000972 TF_octamer
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS

    Graphical View of Domain Structure for InterPro Entry P14859

    ProtoNet protein and cluster: P14859

    3 Blocks protein domains:
    IPB000327 POU domain
    IPB000972 Octamer-binding transcription factor signature
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859
    Similarity: Belongs to the POU transcription factor family. Class-2 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    Find genes that share domains with POU2F1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO2F1_HUMAN, P14859
    Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the
    genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins.
    Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex
    virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and
    HCFC1 thereby enabling the transcription of the viral immediate early genes

         Genatlas biochemistry entry for POU2F1:
    POU domain,class 2,transcription factor 1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ----
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10629049
    GO:0043565sequence-specific DNA binding IDA11997177
         
    Find genes that share ontologies with POU2F1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for POU2F1:
     Increased cell number in S and 

         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pou2f1):
     behavior/neurological  craniofacial  embryogenesis  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  integument  liver/biliary system  mortality/aging  nervous system 
     respiratory system  taste/olfaction  vision/eye 

    Find genes that share phenotypes with POU2F1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for POU2F1: Pou2f1tm1Cav Cd247/Pou2f1Cd247/tm1Tks

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POU2F1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for POU2F1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU2F1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU2F1

    miRNA
    Products:
        
    miRTarBase miRNAs that target POU2F1:
    hsa-mir-30c-5p (MIRT047990), hsa-mir-324-3p (MIRT043000), hsa-mir-98-5p (MIRT027851), hsa-mir-9-5p (MIRT021477), hsa-mir-101-3p (MIRT027386), hsa-mir-34a-5p (MIRT025581), hsa-mir-215-5p (MIRT024501), hsa-mir-26b-5p (MIRT030341), hsa-mir-192-5p (MIRT026960), hsa-mir-15b-5p (MIRT046392)

    Block miRNA regulation of human, mouse, rat POU2F1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate POU2F1 (see all 277):
    hsa-miR-579 hsa-miR-605 hsa-miR-1273d hsa-miR-3622b-3p hsa-miR-761 hsa-miR-520b hsa-miR-3690 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidPOU2F1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for POU2F1
    Predesigned siRNA for gene silencing in human, mouse, rat POU2F1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for POU2F1

    Clone
    Products:
         
    OriGene clones in human, mouse for POU2F1 (see all 16)
    OriGene ORF clones in mouse, rat for POU2F1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): POU2F1 (NM_001198783)
    Sino Biological Human cDNA Clone for POU2F1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU2F1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU2F1
    Addgene plasmids for POU2F1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for POU2F1
    Browse ESI BIO Cell Lines and PureStem Progenitors for POU2F1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PO2F1_HUMAN, P14859: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex ----
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with POU2F1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POU2F1 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase III Transcription Initiation
    RNA Polymerase III Transcription Initiation0.88
    RNA Polymerase III Transcription0.88
    RNA Polymerase III Abortive And Retractive Initiation0.88
    RNA Polymerase III Transcription Initiation From Type 3 Promoter0.80
    2Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes0.38
    Calcium signaling in the CD4+ TCR pathway0.38
    3RNA Polymerase I Promoter Opening
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    4TCR Signaling (Qiagen)
    PKC-Theta Pathway0.68
    5PEDF Induced Signaling
    Glucocorticoid Receptor Signaling0.43


    Find genes that share SuperPaths with POU2F1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for POU2F1
        BRCA1 Pathway
    Glucocorticoid Receptor Signaling
    PKC-Theta Pathway

    2 GeneGo (Thomson Reuters) Pathways for POU2F1
        Immune response IL-3 activation and signaling pathway
    Development Glucocorticoid receptor signaling

    Selected BioSystems Pathways for POU2F1 (see all 6)
        Calcium signaling in the CD4+ TCR pathway
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    Regulation of Androgen receptor activity
    FOXA1 transcription factor network
    ATF-2 transcription factor network


    2 Reactome Pathways for POU2F1
        RNA Polymerase III Transcription Initiation From Type 3 Promoter
    RNA Polymerase III Abortive And Retractive Initiation


        Pathway & Disease-focused RT2 Profiler PCR Array including POU2F1: 
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for POU2F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for POU2F1 (P148591, 2, 3 ENSP000002714114) via UniProtKB, MINT, STRING, and/or I2D (see all 118)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TEAD1P283472, 3, ENSP000003545884MINT-73316 I2D: score=1 STRING: ENSP00000354588
    SP1P080471, 2, 3, ENSP000003293574EBI-624770,EBI-298336 MINT-6803426 MINT-6803452 MINT-6803484 MINT-6803438 MINT-6803470 I2D: score=4 STRING: ENSP00000329357
    ENSG00000228321P013753, ENSP000003928584I2D: score=1 STRING: ENSP00000392858
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006383transcription from RNA polymerase III promoter TAS--
    GO:0010467gene expression TAS--
    GO:0030910olfactory placode formation ----
    GO:0045892negative regulation of transcription, DNA-templated IDA11891224

    Find genes that share ontologies with POU2F1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POU2F1 (PO2F1)

    Selected Novoseek inferred chemical compound relationships for POU2F1 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-napc 78.7 15 9188510 (4), 11463379 (3), 9832505 (2), 9418884 (2)
    gnrh 27.2 8 12188930 (2), 16002402 (2), 15319450 (2), 10674395 (1)
    diamide 23.8 2 9115711 (1), 9489510 (1)
    retinoic acid 13.7 9 7646519 (4), 8455626 (3), 14993281 (1)
    zinc 9.13 8 10455183 (3), 9111349 (1), 7568211 (1), 14669980 (1) (see all 5)
    glyceraldehyde 3-phosphate 8.59 5 12887926 (1), 18682386 (1), 16301215 (1)
    oligonucleotide 6.28 5 8026890 (1), 9518258 (1), 14729276 (1)
    calcium 1.5 1 8964085 (1)
    nitric oxide 0 16 9489510 (6), 19467240 (1), 10674395 (1)
    cyclic amp 0 2 15336700 (1), 14993281 (1)



    Find genes that share compounds with POU2F1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POU2F1 gene (3 alternative transcripts): 
    NM_001198783.1  NM_001198786.1  NM_002697.3  

    Unigene Cluster for POU2F1:

    POU class 2 homeobox 1
    Hs.283402  [show with all ESTs]
    Unigene Representative Sequence: NM_001198783
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367866(uc001geg.3 uc001gee.3 uc010plh.2) ENST00000559038
    ENST00000557909 ENST00000442313 ENST00000560232 ENST00000429375 ENST00000492850
    ENST00000367865(uc001ged.3) ENST00000271411(uc010plg.2 uc001gec.3)
    ENST00000367862(uc001gef.3) ENST00000557874 ENST00000470928 ENST00000443275(uc009wvg.1)
    ENST00000490100 ENST00000559648 ENST00000420254 ENST00000541643 ENST00000452019

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate POU2F1 (see all 277):
    hsa-miR-579 hsa-miR-605 hsa-miR-1273d hsa-miR-3622b-3p hsa-miR-761 hsa-miR-520b hsa-miR-3690 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidPOU2F1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for POU2F1
    Predesigned siRNA for gene silencing in human, mouse, rat POU2F1
    Clone
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    OriGene clones in human, mouse for POU2F1 (see all 16)
    OriGene ORF clones in mouse, rat for POU2F1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): POU2F1 (NM_001198783)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU2F1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU2F1
    Addgene plasmids for POU2F1 
    Primer
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    OriGene qPCR primer pairs and template standards for POU2F1
    OriGene qSTAR qPCR primer pairs in human, mouse for POU2F1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POU2F1
      QuantiTect SYBR Green Assays in human, mouse, rat POU2F1
      QuantiFast Probe-based Assays in human, mouse, rat POU2F1

    Additional mRNA sequence: 

    AK091438.1 AK124826.1 AK303201.1 AK308004.1 AY113189.1 BC001664.2 BC003571.1 BC007388.2 
    BC037864.2 BC052274.1 CR627124.1 NR_037163.1 S66901.1 X13403.1 

    22 DOTS entries:

    DT.95140199  DT.95171994  DT.312945  DT.100788108  DT.101983687  DT.92434662  DT.203889  DT.309153 
    DT.100788111  DT.121436911  DT.100808918  DT.121436837  DT.100026449  DT.121436891  DT.437142  DT.91839750 
    DT.95171990  DT.95348533  DT.99934717  DT.100739535  DT.86848723  DT.92021422 

    Selected AceView cDNA sequences (see all 145):

    BQ938715 S66901 BG388369 BE269179 BC052274 BM040945 BE560757 BE396853 
    BM782895 BC003571 BQ068393 BM452501 BM694716 BQ213592 S66902 BE385281 
    AU122313 NM_002697 AU124383 BP339121 BQ928677 BC041822 BC007388 BG752224 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for POU2F1 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
    SP1:                          -           -     -     -           -     -     -                                                     -                           
    SP2:                                                              -     -     -                                                     -                           
    SP3:                          -     -     -     -     -           -     -     -                                                     -                           
    SP4:                                                                                                                                -                           
    SP5:                                                              -     -     -                                               -     -                           

    ExUns: 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                            -     -         
    SP5:                                                            


    ECgene alternative splicing isoforms for POU2F1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    POU2F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTGGAGAA
    POU2F1 Expression
    About this image


    POU2F1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Fetal Corneal Superficial Epithelial Cells Corneal Epithelium
     
     Epithelial Cells
             Fetal Corneal Superficial Epithelial Cells Corneal Epithelium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Fibroblasts
             Keratocytes Corneal Stroma
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    POU2F1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POU2F1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.283402

    UniProtKB/Swiss-Prot: PO2F1_HUMAN, P14859
    Tissue specificity: Ubiquitous. Isoform 2 is lymphocyte-specific

        Pathway & Disease-focused RT2 Profiler PCR Array including POU2F1: 
              Circadian Rhythms in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for POU2F1
    OriGene qSTAR qPCR primer pairs in human, mouse for POU2F1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POU2F1
    QuantiTect SYBR Green Assays in human, mouse, rat POU2F1
    QuantiFast Probe-based Assays in human, mouse, rat POU2F1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2F1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for POU2F1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou2f11 , 5 POU domain, class 2, transcription factor 11, 5 90.5(n)1
    93.46(a)1
      1 (73.21 cM)5
    189861  NM_011137.31  NP_035267.21 
     1658651545 
    chicken
    (Gallus gallus)
    Aves POU2F11 POU class 2 homeobox 1 88.96(n)
    95.12(a)
      396463  NM_205472.1  NP_990803.1 
    lizard
    (Anolis carolinensis)
    Reptilia POU2F16
    POU class 2 homeobox 1
    94(a)
    1 ↔ 1
    3(163498672-163661906)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.12652 Xenopus laevis Oct-1 mRNA 81.12(n)    X57165.1 
    zebrafish
    (Danio rerio)
    Actinopterygii oct12 octamer-binding transcription factor 1 75.16(n)   30715  AF030519.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nub3 neuroblast determination transcription
    factor
    75(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-186
    Protein CEH-18, isoform c (ceh-18) mRNA, complete ...
    27(a)
    1 → many
    X(3843379-3857797) WBGene00000441


    ENSEMBL Gene Tree for POU2F1 (if available)
    TreeFam Gene Tree for POU2F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POU2F1 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F12  POU3F42  POU1F12  POU3F32  
    POU4F32  POU3F22  POU2F22  POU5F1B2  POU4F12  POU6F12  POU5F12  
    16 SIMAP similar genes for POU2F1 using alignment to 3 protein entries:     PO2F1_HUMAN (see all proteins):
    OCT6    OCT-2    POU3F1    POU6F1    POU1F1    POU5F1P4
    POU2F2    POU2F3    POU3F4    POU5F1    NKX2-5    POU3F2
    POU4F3    POU5F1B    POU5F1P1    POU3F3

    Find genes that share paralogs with POU2F1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POU2F1 (see all 4063)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358164
    A breast cancer sample4--see VAR_0358162 S F mis40--------
    rs1877466391,2
    --167188212(+) ACACAC/TACACT 3 -- us2k10--------
    rs1437566231,2
    C--167188269(+) AAAGAA/GCAAAA 3 -- us2k10--------
    rs1142291361,2
    F--167188585(+) TACCAC/AGAACA 3 -- us2k11Minor allele frequency- A:0.02NA 120
    rs14978611,2
    C,F,H--167188630(-) AAGCTA/GTTGTC 3 -- us2k19Minor allele frequency- G:0.03MN NS EA NA WA 1006
    rs1928852621,2
    C--167188644(+) CTGTAC/TTTGCA 3 -- us2k10--------
    rs1410846281,2
    --167188660(+) AAAGGA/GGTCCA 3 -- us2k10--------
    rs1848948991,2
    --167188790(+) TATCTC/GTCAAG 3 -- us2k10--------
    rs1889697171,2
    --167188886(+) AAATAA/GGGCTT 3 -- us2k10--------
    rs1501948131,2
    --167188992(+) GAAAGA/GTATGT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for POU2F1 (167190066 - 167396582 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for POU2F1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719195CNV Deletion23290073
    nsv3421CNV Insertion18451855
    nsv3432CNV Insertion18451855
    nsv831803CNV Loss17160897
    nsv872523CNV Loss21882294
    nsv831814CNV Loss17160897
    nsv872524CNV Gain21882294
    nsv521232CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POU2F1
    DNA2.0 Custom Variant and Variant Library Synthesis for POU2F1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164175    OMIM disorders: --

    1 disease for POU2F1:    
    About MalaCards
    hereditary persistence of fetal hemoglobin


    Find genes that share disorders with POU2F1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for POU2F1 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 53.9 14 1684335 (2), 1358755 (1), 7568211 (1), 7891704 (1) (see all 13)
    carcinoma embryonal 30.4 3 8455626 (3)
    retinoblastoma 21.6 2 7872668 (1), 10437913 (1)
    choriocarcinoma 5.03 1 16005513 (1)
    carcinoma 3.08 2 16278805 (1)
    metastasis 2.74 1 8502621 (1)
    cancer 0.97 3 10544969 (2), 19058140 (1)
    inflammatory bowel diseases 0 1 12019209 (1)
    breast carcinoma 0 1 10544969 (1)
    necrosis 0 2 17192276 (2)

    Genetic Association Database (GAD): POU2F1
    Human Genome Epidemiology (HuGE) Navigator: POU2F1 (11 documents)

    Export disorders for POU2F1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POU2F1 gene, integrated from 10 sources (see all 388) (see top 10):
    (articles sorted by number of sources associating them with POU2F1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. (PubMed id 1684878)1, 2, 9 Segil N.... Heintz N. (Science 1991)
    2. Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1. (PubMed id 14612514)1, 2, 9 Schild-Poulter C.... Hache R.J.G. (Cancer Res. 2003)
    3. Differential phosphorylation of the transcription factor Oct1 during the cell cycle. (PubMed id 1887216)1, 3, 9 Roberts S.B....Heintz N. (Science 1991)
    4. Human Oct-1L isoform has tissue-specific expression pattern similar to Oct-2. (PubMed id 12663137)1, 2, 9 Luchina N.N.... Pankratova E.V. (Immunol. Lett. 2003)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response. (PubMed id 19898263)1, 4 Becker M.L....Stricker B.H. (Pharmacogenet. Genomics 2010)
    7. Association of the POU class 2 homeobox 1 gene (POU2F1) with susceptibility to Type 2 diabetes in Chinese populations. (PubMed id 21059098)1, 4 Ng M.C....Chan J.C. (Diabet. Med. 2010)
    8. Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. (PubMed id 20886065)1, 4 Cleynen I....Vermeire S. (PLoS ONE 2010)
    9. Genetic risk profiling and prediction of disease course in Crohn's disease patients. (PubMed id 19422935)1, 4 Henckaerts L....Vermeire S. (Clin. Gastroenterol. Hepatol. 2009)
    10. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. (PubMed id 19174780)1, 4 Weersma R.K.... Vermeire S. (Am. J. Gastroenterol. 2009)
    11. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1, 4 Cheung C.L....Kung A.W. (Hum. Mol. Genet. 2009)
    12. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    13. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    14. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (PubMed id 18940312)1, 4 Yuan X....Mooser V. (Am. J. Hum. Genet. 2008)
    15. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    16. Identification of hippocampus-related candidate genes for Alzheimer's disease. (PubMed id 15786443)1, 4 Taguchi K....Miki T. (Ann. Neurol. 2005)
    17. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    18. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    19. Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP. (PubMed id 10629049)1, 2 Mahajan S.S. and Wilson A.C. (Mol. Cell. Biol. 2000)
    20. Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter. (PubMed id 10480874)1, 2 Prefontaine G.G....Hache R.J.G. (J. Biol. Chem. 1999)
    21. Solution structure of the Oct-1 POU homeodomain determined by NMR and restrained molecular dynamics. (PubMed id 7663141)1, 2 Cox M.... Kaptein R. (J. Biomol. NMR 1995)
    22. Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules. (PubMed id 8156594)1, 2 Klemm J.D.... Pabo C.O. (Cell 1994)
    23. Solution structure of the POU-specific DNA-binding domain of Oct-1. (PubMed id 8479524)1, 2 Dekker N....Kaptein R. (Nature 1993)
    24. The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain. (PubMed id 8462099)1, 2 Assa-Munt N.... Wright P.E. (Cell 1993)
    25. The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. (PubMed id 2905684)1, 2 Sturm R.A.... Herr W. (Genes Dev. 1988)
    26. Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter. (PubMed id 7642649)1, 9 Nakshatri H....Currie R.A. (J. Biol. Chem. 1995)
    27. A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. (PubMed id 19171782)1, 9 Kang J....Tantin D. (amp 2009)
    28. Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor. (PubMed id 11134019)1, 9 Kakizawa T....Hashizume K. (J. Biol. Chem. 2001)
    29. Chromosomal structure and expression of the human OTF1 locus encoding the Oct-1 protein. (PubMed id 8314572)1, 9 Sturm R.A....Evans G.A. (Genomics 1993)
    30. Inhibition of AR-mediated transcription by binding of Oct1 to a motif enriched in AR-occupied regions. (PubMed id 19058140)1, 9 Jariwala U....Coetzee G.A. (Prostate 2009)
    31. A far-upstream Oct-1 motif regulates cytokine-induced transcription of the human inducible nitric oxide synthase gene. (PubMed id 19467240)1, 9 Park K.S....Geller D.A. (J. Mol. Biol. 2009)
    32. Oct-1 induces pituitary tumor transforming gene expression in endocrine tumors. (PubMed id 18550719)1, 9 Zhou C....Melmed S. (Endocr. Relat. Cancer 2008)
    33. Oct-1 is involved in the transcriptional repression of the p15(INK4b) gene. (PubMed id 17316622)1, 9 Hitomi T....Sakai T. (FEBS Lett. 2007)
    34. Functional interaction between Oct-1 and retinoid X receptor. (PubMed id 10383413)1, 9 Kakizawa T....Hashizume K. (J. Biol. Chem. 1999)
    35. Regulation of NF-kappaB-dependent gene expression by the POU domain transcription factor Oct-1. (PubMed id 17192276)1, 9 dela Paz N.G....Collins T. (J. Biol. Chem. 2007)
    36. The regulation of the Oct-1 gene transcription is mediated by two promoters. (PubMed id 12853155)1, 9 Pankratova E.V....Krivega I.V. (Immunol. Lett. 2003)
    37. BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs. (PubMed id 11777930)1, 9 Fan W....Zhan Q. (J. Biol. Chem. 2002)
    38. Insulin stimulates the expression of carbohydrate response element binding protein (ChREBP) by attenuating the repressive effect of Pit-1, Oct-1/Oct-2, and Unc-86 homeodomain protein octamer transcription factor-1. (PubMed id 19359385)1, 9 Sirek A.S....Jin T. (Endocrinology 2009)
    39. LOX-1 receptor blockade abrogates oxLDL-induced oxidative DNA damage and prevents activation of the transcriptional repressor Oct-1 in human coronary arterial endothelium. (PubMed id 18390905)1, 9 Thum T. and Borlak J. (J. Biol. Chem. 2008)
    40. T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro. (PubMed id 16301215)1, 9 Lewinsky R.H....Troelsen J.T. (Hum. Mol. Genet. 2005)
    41. Oct-1 maintains an intermediate, stable state of HLA-DRA promoter repression in Rb-defective cells: an Oct-1-containing repressosome that prevents NF-Y binding to the HLA-DRA promoter. (PubMed id 15105429)1, 9 Osborne A.R....Blanck G. (J. Biol. Chem. 2004)
    42. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase the binding activity and nuclear level of Oct-1 in mononuclear cells. (PubMed id 12144930)1, 9 Ortego M....Egido J. (Eur. J. Pharmacol. 2002)
    43. Involvement of Oct-1 in the regulation of CDKN1A in response to clinically relevant doses of ionizing radiation. (PubMed id 19118657)1, 9 Nenoi M....Kakimoto A. (Biochim. Biophys. Acta 2009)
    44. Regulation of basal and induced expression of C-reactive protein through an overlapping element for OCT-1 and NF-kappaB on the proximal promoter. (PubMed id 16116232)1, 9 Voleti B. and Agrawal A. (J. Immunol. 2005)
    45. STAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression. (PubMed id 14645506)1, 9 MagnAc S....Dusanter-Fourt I. (Mol. Cell. Biol. 2003)
    46. Oct-1 potentiates CREB-driven cyclin D1 promoter activation via a phospho-CREB- and CREB binding protein-independent mechanism. (PubMed id 12391146)1, 9 Boulon S....Philips A. (Mol. Cell. Biol. 2002)
    47. Octamer transcription factor-1 enhances hepatic nuclear factor- 1alpha-mediated activation of the human UDP glucuronosyltransferase 2B7 promoter. (PubMed id 10779377)1, 9 Ishii Y.... Mackenzie P.I. (Mol. Pharmacol. 2000)
    48. The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression. (PubMed id 8668525)1, 9 StrAPm A.C....Westin G. (Nucleic Acids Res. 1996)
    49. Octamer-binding transcription factor-1 gene is upregulated in primary varicose veins. (PubMed id 18083338)1, 9 Jeong G.A....Chang J.H. (Ann Vasc Surg 2008)
    50. Oct-1 is involved in the transcriptional repression of the gonadotropin-releasing hormone receptor gene. (PubMed id 12446597)1, 9 Cheng C.K....Leung P.C. (Endocrinology 2002)
    51. Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase. (PubMed id 9537509)1, 9 Nie J....Taniguchi T. (FEBS Lett. 1998)
    52. Enhanced activation of the human histone H2B promoter by an Oct-1 variant generated by alternative splicing. (PubMed id 8227066)1, 9 Das G. and Herr W. (J. Biol. Chem. 1993)
    53. The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1. (PubMed id 16002402)1, 9 Rave-Harel N....Mellon P.L. (J. Biol. Chem. 2005)
    54. HCF-dependent nuclear import of VP16. (PubMed id 9889203)1, 9 La BoissiA"re S....O'Hare P. (EMBO J. 1999)
    55. The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1. (PubMed id 9418884)1, 9 Wong M.W.... Hernandez N. (Mol. Cell. Biol. 1998)
    56. The octamer motif present in the Rex-1 promoter binds Oct-1 and Oct-3 expressed by EC cells and ES cells. (PubMed id 7945330)1, 9 Rosfjord E. and Rizzino A. (Biochem. Biophys. Res. Commun. 1994)
    57. The gene for the ubiquitous octamer-binding protein Oct-1 is on human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on mouse chromosome 1. (PubMed id 2341156)1, 9 Hsieh C.L....Francke U. (Genomics 1990)
    58. High-mobility group protein HMGB2 regulates human erythroid differentiation through trans-activation of GFI1B transcription. (PubMed id 19965638)1, 9 Laurent B....DumAcnil D. (Blood 2010)
    59. O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1. (PubMed id 19070619)1, 9 Lim K. and Chang H.I. (FEBS Lett. 2009)
    60. Histone 2B (H2B) expression is confined to a proper NAD+/NADH redox status. (PubMed id 18682386)1, 9 Dai R.P....Luo Y. (J. Biol. Chem. 2008)
    61. GATA-1 and Oct-1 are required for expression of the human alpha-hemoglobin-stabilizing protein gene. (PubMed id 16186125)1, 9 Gallagher P.G....Bodine D.M. (J. Biol. Chem. 2005)
    62. The herpes simplex virus VP16-induced complex: the makings of a regulatory switch. (PubMed id 12826401)2, 9 Wysocka J. and Herr W. (Trends Biochem. Sci. 2003)
    63. S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. (PubMed id 12887926)1, 9 Zheng L.... Luo Y. (Cell 2003)
    64. Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. (PubMed id 11891224)1, 9 Gonzalez M.M. and Carlberg C. (J. Biol. Chem. 2002)
    65. Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors. (PubMed id 12019209)1, 9 van Heel D.A....Kwiatkowski D. (Hum. Mol. Genet. 2002)
    66. Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator. (PubMed id 11380252)1, 9 Lee L....Luisi B. (Biochemistry 2001)
    67. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    68. Regulation of Oct1/Pou2f1 transcription activity by O-GlcNAcylation. (PubMed id 23580612)1 Kang J....Tantin D. (FASEB J. 2013)
    69. Long-term cisplatin exposure promotes methylation of the OCT1 gene in human esophageal cancer cells. (PubMed id 23053895)1 Lin R....Li J. (Dig. Dis. Sci. 2013)
    70. [The new isoform of Oct-1 transcription factor is transcribed from alternative promoter]. (PubMed id 24466753)1 Krylova I.D....Pankratova E.V. (Mol. Biol. (Mosk.) 2013)
    71. New alternative promoter in regulation of the Oct-1 human gene transcription. (PubMed id 23657650)1 Portseva T.N....Pankratova E.V. (Dokl. Biochem. Biophys. 2013)
    72. HOXA1 gene is not potentially related to ventricular septal defect in Chinese children. (PubMed id 22777240)1 Liu J....Gao B. (Pediatr Cardiol 2013)
    73. STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1. (PubMed id 23172665)1 Wang Z....Mei Q. (Carcinogenesis 2013)
    74. Oct-1 recruitment to the nuclear envelope in adult-onset autosomal dominant leukodystrophy. (PubMed id 23261988)1 Columbaro M....Lattanzi G. (Biochim. Biophys. Acta 2013)
    75. Gadd45a transcriptional induction elicited by the Aurora kinase inhibitor MK-0457 in Bcr-Abl-expressing cells is driven by Oct-1 transcription factor. (PubMed id 22521726)1 Mancini M....Santucci M.A. (Leuk. Res. 2012)
    76. [Effects of hOCT1 and ABCB1 gene on the efficacy of imatinib mesylate in chronic myelocytic leukemia]. (PubMed id 22883199)1 Chen W.W....Wang Z.X. (Zhonghua Yi Xue Za Zhi 2012)
    77. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    78. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    79. Oct-1 cooperates with the TATA binding initiation complex to control rapid transcription of human iNOS. (PubMed id 22349263)1 Reveneau S....Pance A. (Cell. Mol. Life Sci. 2012)
    80. Interplay between minor and major groove-binding transcription factors Sox2 and Oct1 in translocation on DNA studied by paramagnetic and diamagnetic NMR. (PubMed id 22396547)1 Takayama Y. and Clore G.M. (J. Biol. Chem. 2012)
    81. Negative regulation of human U6 snRNA promoter by p38 kinase through Oct-1. (PubMed id 22310390)1 Lin B.R. and Natarajan V. (Gene 2012)
    82. Oct1 regulates cell growth of LNCaP cells and is a prognostic factor for prostate cancer. (PubMed id 21387309)1 Obinata D....Inoue S. (Int. J. Cancer 2012)
    83. Oncosecretomics coupled to bioenergetics identifies I+-amino adipic acid, isoleucine and GABA as potential biomarkers of cancer: Differential expression of c-Myc, Oct1 and KLF4 coordinates metabolic changes. (PubMed id 22842522)1 Bellance N....Nagrath D. (Biochim. Biophys. Acta 2012)
    84. Oct-1 acts as a transcriptional repressor on the C-reactive protein promoter. (PubMed id 22750226)1 Voleti B....Agrawal A. (Mol. Immunol. 2012)
    85. Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT(3) antagonists tropisetron and ondansetron. (PubMed id 20921968)1 Tzvetkov M.V....BrockmAPller J. (Pharmacogenomics J. 2012)
    86. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    87. Arterial flow reduces oxidative stress via an antioxidant response element and Oct-1 binding site within the NADPH oxidase 4 promoter in endothelial cells. (PubMed id 21399967)1 Goettsch C....Morawietz H. (Basic Res. Cardiol. 2011)
    88. Reactive oxygen species downregulate catalase expression via methylation of a CpG island in the Oct-1 promoter. (PubMed id 21985966)1 Quan X....Jung G. (FEBS Lett. 2011)
    89. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    90. OCT1 Expression in adipocytes could contribute to increased metformin action in obese subjects. (PubMed id 20956498)1 Moreno-Navarrete J.M....FernA!ndez-Real J.M. (Diabetes 2011)
    91. Genetically polymorphic OCT1: another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol. (PubMed id 21562485)1 Tzvetkov M.V....BrockmAPller J. (Clin. Pharmacol. Ther. 2011)
    92. Cellular transcription factor Oct-1 interacts with the Epstein-Barr virus BRLF1 protein to promote disruption of viral latency. (PubMed id 21697476)1 Robinson A.R....Kenney S.C. (J. Virol. 2011)
    93. Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (EMBO Rep. 2011)
    94. Replication stress induces 53BP1-containing OPT domains in G1 cells. (PubMed id 21444690)1 Harrigan J.A....Jackson S.P. (J. Cell Biol. 2011)
    95. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    96. Intra- and intermolecular translocation of the bi-domain transcription factor Oct1 characterized by liquid crystal and paramagnetic NMR. (PubMed id 21555551)1 Takayama Y. and Clore G.M. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    97. Allele-specific transcription of the asthma-associated PHD finger protein 11 gene (PHF11) modulated by octamer-binding transcription factor 1 (Oct-1). (PubMed id 21320718)1 Holt R.J....Moffatt M.F. (J. Allergy Clin. Immunol. 2011)
    98. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    99. Dynamic regulation of Oct1 during mitosis by phosphorylation and ubiquitination. (PubMed id 21897860)1 Kang J....Tantin D. (PLoS ONE 2011)
    100. Correlation between genetic polymorphisms of the hOCT1 and MDR1 genes and the response to imatinib in patients newly diagnosed with chronic-phase chronic myeloid leukemia. (PubMed id 21185600)1 Maffioli M....Cervantes F. (Leuk. Res. 2011)
    101. OCT-1 function varies with cell lineage but is not influenced by BCR-ABL. (PubMed id 20971815)1 Engler J.R....White D.L. (Haematologica 2011)
    102. Facilitated DNA search by multidomain transcription factors: cross talk via a flexible linker. (PubMed id 20713004)1 Vuzman D....Levy Y. (Biophys. J. 2010)
    103. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    104. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    105. Oct-1 is responsible for the C-33T polymorphism effect in the IL-4 promoter. (PubMed id 19804407)1 Gervaziev Y.V....Gervazieva V.B. (Int. J. Immunogenet. 2010)
    106. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    107. BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription. (PubMed id 20215511)1 Harte M.T.... Harkin D.P. (Cancer Res. 2010)
    108. Induction of endogenous gamma-globin gene expression with decoy oligonucleotide targeting Oct-1 transcription factor consensus sequence. (PubMed id 19327156)1 Xu X.S....Wang G. (amp 2009)
    109. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    110. POU homeodomain protein Oct-1 functions as a sensor for cyclic AMP. (PubMed id 19617623)1 Wang P....Jin T. (J. Biol. Chem. 2009)
    111. Histone acetylation characterizes chromatin presetting by NF1 and Oct1 and enhances glucocorticoid receptor binding to the MMTV promoter. (PubMed id 19463811)1 Astrand C....Wrange O. (Exp. Cell Res. 2009)
    112. Expression of the muscle atrophy factor muscle atrophy F-box is suppressed by testosterone. (PubMed id 18599544)1 Zhao W....Cardozo C.P. (Endocrinology 2008)
    113. Factors affecting sensitivity to antitumor platinum derivatives of human colorectal tumor cell lines. (PubMed id 18030470)1 Kitada N....Yokoyama T. (Cancer Chemother. Pharmacol. 2008)
    114. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    115. Analysis of the transcriptional regulation of the FABP2 promoter haplotypes by PPARgamma/RXRalpha and Oct-1. (PubMed id 18634911)1 BAPhme M....Klapper M. (Biochim. Biophys. Acta 2008)
    116. Global jumping and domain-specific intersegment transfer between DNA cognate sites of the multidomain transcription factor Oct-1. (PubMed id 18772384)1 Doucleff M. and Clore G.M. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    117. Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. (PubMed id 17273778)1 Katoh Y. and Katoh M. (Int. J. Oncol. 2007)
    118. Production of specific mRNA transcripts, usage of an alternate promoter, and octamer-binding transcription factors influence the surface expression levels of the HIV coreceptor CCR5 on primary T cells. (PubMed id 17442950)1 Mummidi S....Ahuja S.K. (J. Immunol. 2007)
    119. Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer. (PubMed id 18000219)1 Hosey A.M....Harkin D.P. (J. Natl. Cancer Inst. 2007)
    120. DNA-PK phosphorylation sites on Oct-1 promote cell survival following DNA damage. (PubMed id 17213819)1 Schild-Poulter C....HachAc R.J. (Oncogene 2007)
    121. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    122. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    123. Oct-1 DNA binding activity unresponsive to retinoblastoma protein expression prevents MHC class II induction in a non-small cell lung carcinoma cell line. (PubMed id 16360016)1 Osborne A.R....Blanck G. (Mol. Immunol. 2006)
    124. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    125. Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5. (PubMed id 16025120)1 Bertolino E....Singh H. (Nat. Immunol. 2005)
    126. T to C substitution at -175 or -173 of the gamma-globin promoter affects GATA-1 and Oct-1 binding in vitro differently but can independently reproduce the hereditary persistence of fetal hemoglobin phenotype in transgenic mice. (PubMed id 15613485)1 Liu L.R....Zhang J.W. (J. Biol. Chem. 2005)
    127. Silencing of Fshr occurs through a conserved, hypersensitive site in the first intron. (PubMed id 15817654)1 Hermann B.P. and Heckert L.L. (Mol. Endocrinol. 2005)
    128. Functional interaction of Oct transcription factors with the family of repeats in Epstein-Barr virus oriP. (PubMed id 15831936)1 Almqvist J....Ernberg I. (J. Gen. Virol. 2005)
    129. TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1. (PubMed id 15138251)1 Rave-Harel N....Mellon P.L. (J. Biol. Chem. 2004)
    130. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    131. Inhibition of HIV-1 TAR RNA-Tat peptide complexation using poly(acrylic acid). (PubMed id 15207707)1 Zhao H....Jiang L. (Biochem. Biophys. Res. Commun. 2004)
    132. Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex. (PubMed id 14559893)1 Williams D.C....Clore G.M. (J. Biol. Chem. 2004)
    133. OBF1 enhances transcriptional potential of Oct1. (PubMed id 12727885)1 Lins K....SchAPler H.R. (EMBO J. 2003)
    134. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell- proliferation factor HCF-1. (PubMed id 12670868)1 Wysocka J.... Herr W. (Genes Dev. 2003)
    135. p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y. (PubMed id 14586402)1 Hirose T....Sakai T. (Oncogene 2003)
    136. Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements. (PubMed id 12672812)1 Schaffer A....Casali P. (J. Biol. Chem. 2003)
    137. Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. (PubMed id 12923055)1 RemAcnyi A....Wilmanns M. (amp 2003)
    138. Expression of B-lymphocyte-associated transcription factors in human T-cell neoplasms. (PubMed id 12598320)1 Marafioti T....Pileri S.A. (Am. J. Pathol. 2003)
    139. Gene switching by metabolic enzymes--how did you get on the invitation list? (PubMed id 12887915)1 McKnight S. (Cell 2003)
    140. [Regulation of human oct-1 gene transcription involves two promotors]. (PubMed id 12669425)1 Zhenilo S.V....PolianovskiA- O.L. (Genetika 2003)
    141. STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene. (PubMed id 14522952)1 Lerner L....Darnell J.E. (amp 2003)
    142. Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication. (PubMed id 12393188)1 Matheos D....Zannis-Hadjopoulos M. (Biochim. Biophys. Acta 2002)
    143. Crystallization of the Oct-1/SNAP190 peptide/DNA complex. (PubMed id 11856838)1 Hovde S....Geiger J.H. (Acta Crystallogr. D Biol. Crystallogr. 2002)
    144. Androgen receptor interactions with Oct-1 and Brn-1 are physically and functionally distinct. (PubMed id 11997177)1 GonzA!lez M.I....Robins D.M. (Mol. Cell. Endocrinol. 2002)
    145. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    146. Oct-1 preferentially interacts with androgen receptor in a DNA-dependent manner that facilitates recruitment of SRC-1. (PubMed id 11096094)1 Gonzalez M.I. and Robins D.M. (J. Biol. Chem. 2001)
    147. Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping. (PubMed id 11583619)1 RemAcnyi A....Wilmanns M. (Mol. Cell 2001)
    148. A map of protein-protein contacts within the small nuclear RNA- activating protein complex SNAPc. (PubMed id 11056176)1 Ma B. and Hernandez N. (J. Biol. Chem. 2001)
    149. The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase. (PubMed id 11279128)1 Schild-Poulter C....HachAc R.J. (J. Biol. Chem. 2001)
    150. A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. (PubMed id 10976766)1 Gunther M.... Brison O. (Mol. Cell. Biochem. 2000)
    151. Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding. (PubMed id 10490647)1 Wang J.M....HachAc R.J. (Mol. Cell. Biol. 1999)
    152. Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface. (PubMed id 10541551)1 Chasman D.... Pabo C.O. (Genes Dev. 1999)
    153. Adenovirus preterminal protein binds to the CAD enzyme at active sites of viral DNA replication on the nuclear matrix. (PubMed id 9525610)1 Angeletti P.C. and Engler J.A. (J. Virol. 1998)
    154. Recruitment of octamer transcription factors to DNA by glucocorticoid receptor. (PubMed id 9584182)1 PrAcfontaine G.G....HachAc R.J. (Mol. Cell. Biol. 1998)
    155. High mobility group I/Y protein functions as a specific cofactor for Oct-2A: mapping of interaction domains. (PubMed id 9823775)1 Abdulkadir S.A....Ono S.J. (J. Leukoc. Biol. 1998)
    156. Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation. (PubMed id 9242494)1 Andersen B....Rosenfeld M.G. (amp 1997)
    157. The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors. (PubMed id 9368058)1 Inamoto S....Roeder R.G. (J. Biol. Chem. 1997)
    158. High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors. (PubMed id 7720710)1 Zwilling S....Wirth T. (EMBO J. 1995)
    159. The human OTF1 locus which overlaps the CD3Z gene is located at 1q22--&gt;q23. (PubMed id 7842742)1 Sturm R.A....Sutherland G.R. (Cytogenet. Cell Genet. 1995)
    160. The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP. (PubMed id 8202368)1 Zwilling S....Wirth T. (Nucleic Acids Res. 1994)
    161. In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. (PubMed id 7690421)1 Jeang K.T....Fan H. (J. Virol. 1993)
    162. Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16). (PubMed id 8454622)1 Kristie T.M. and Sharp P.A. (J. Biol. Chem. 1993)
    163. Characterization of an Oct1 orthologue in the channel catfish, Ictalurus punctatus: a negative regulator of immunoglobulin gene transcription? (PubMed id 17266766)9 Lennard M.L....Warr G.W. (BMC Mol. Biol. 2007)
    164. Differential positive control by Oct-1 and Oct-2: activation of a transcriptionally silent motif through Oct-1 and VP16 corecruitment. (PubMed id 8422989)9 Cleary M.A....Herr W. (amp 1993)
    165. Mouse Oct-1 contains a composite homeodomain of human Oct-1 and Oct-2. (PubMed id 8441632)9 Suzuki N....SchAPler H.R. (Nucleic Acids Res. 1993)
    166. OCT-1 is over-expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells. (PubMed id 16278805)9 Almeida R....David L. (J. Pathol. 2005)
    167. Nitric oxide inhibits Oct-1 DNA binding activity in cultured vascular smooth muscle cells. (PubMed id 9489510)9 Liu X.K....Andrawis N.S. (Life Sci. 1998)
    168. Cloning, sequencing and expression of two isoforms of the murine oct-1 transcription factor. (PubMed id 7711063)9 Jaffe J....Laskov R. (Biochim. Biophys. Acta 1995)
    169. [Alternative promoters and oct-1 gene tissue-specific regulation]. (PubMed id 16358731)9 (Mol. Biol. (Mosk.) 2005)
    170. Oct-1 enhances the in vitro replication of a mammalian autonomously replicating DNA sequence. (PubMed id 9518258)9 Matheos D.D....Zannis-Hadjopoulos M. (J. Cell. Biochem. 1998)
    171. Dissociation of Oct-1 from the nuclear peripheral structure induces the cellular aging-associated collagenase gene expression. (PubMed id 9398664)9 Imai S....Takano T. (Mol. Biol. Cell 1997)
    172. Characterization of a trimeric complex containing Oct-1, SNAPc, and DNA. (PubMed id 9188510)9 Ford E. and Hernandez N. (J. Biol. Chem. 1997)
    173. Oct-1 [corrected] and Oct-2 DNA-binding site specificity is regulated in vitro by different kinases. (PubMed id 8645173)9 Grenfell S.J....Thomas N.S. (Biochem. J. 1996)
    174. Repression of the human papillomavirus type 18 enhancer by the cellular transcription factor Oct-1. (PubMed id 1654457)9 Hoppe-Seyler F....zur Hausen H. (J. Virol. 1991)
    175. Characterization of a cellular factor which interacts functionally with Oct-1 in the assembly of a multicomponent transcription complex. (PubMed id 2175881)9 Katan M....O'Hare P. (Nucleic Acids Res. 1990)
    176. Cloning, genomic organization, expression, and effect on beta-casein promoter activity of a novel isoform of the mouse Oct-1 transcription factor. (PubMed id 14729276)9 Zhao F.Q....Oka T. (Gene 2004)
    177. NFI and Oct-1 bend the Ad5 origin in the same direction leading to optimal DNA replication. (PubMed id 15576348)9 Mysiak M.E....van der Vliet P.C. (Nucleic Acids Res. 2004)
    178. POU domain factors in neural development. (PubMed id 10026784)9 Schonemann M.D....Rosenfeld M.G. (Adv. Exp. Med. Biol. 1998)
    179. Non-cell autonomous induction of apoptosis and loss of posterior structures by activation domain-specific interactions of Oct-1 in the Xenopus embryo. (PubMed id 10200537)9 Veenstra G.J....DestrAce O.H. (Cell Death Differ. 1998)
    180. Differential transactivation potential of Oct1 and Oct2 is determined by additional B cell-specific activities. (PubMed id 8157005)9 Pfisterer P....Wirth T. (EMBO J. 1994)
    181. Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cells. (PubMed id 8455626)9 Hsu W. and Chen-Kiang S. (Mol. Cell. Biol. 1993)
    182. Activation of octamer-containing promoters by either octamer-binding transcription factor 1 (OTF-1) or OTF-2 and requirement of an additional B-cell-specific component for optimal transcription of immunoglobulin promoters. (PubMed id 2123291)9 Pierani A....Roeder R.G. (Mol. Cell. Biol. 1990)
    183. BOB.1 of the channel catfish, Ictalurus punctatus: not a transcriptional coactivator? (PubMed id 19041136)9 Richard M.L....Warr G.W. (Mol. Immunol. 2009)
    184. Transcriptional regulation of the human prostacyclin receptor gene is dependent on Sp1, PU.1 and Oct-1 in megakaryocytes and endothelial cells. (PubMed id 19118563)9 Turner E.C. and Kinsella B.T. (J. Mol. Biol. 2009)
    185. Direct interactions of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta protein with the cellular protein octamer-1 and DNA are critical for specifying transactivation of a delayed-early promoter and stimulating viral reactivation. (PubMed id 17537858)9 Carroll K.D....Lukac D.M. (J. Virol. 2007)
    186. Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression. (PubMed id 16186795)9 Heckman C.A....Boxer L.M. (Oncogene 2006)
    187. Prolactin signals via Stat5 and Oct-1 to the proximal cyclin D1 promoter. (PubMed id 15885880)9 Brockman J.L. and Schuler L.A. (Mol. Cell. Endocrinol. 2005)
    188. Regulation of oct-1 gene transcription is different in lymphoid and non-lymphoid cells. (PubMed id 14505828)9 Zhenilo S....Polanovsky O. (Biochimie 2003)
    189. Unique function for carboxyl-terminal domain of Oct-2 in Ig-secreting cells. (PubMed id 11591767)9 Sharif M.N....Eckhardt L.A. (J. Immunol. 2001)
    190. A positioned nucleosome on the human U6 promoter allows recruitment of SNAPc by the Oct-1 POU domain. (PubMed id 11463379)9 Zhao X....Hernandez N. (Mol. Cell 2001)
    191. Herpes simplex virus transactivator VP16 discriminates between HCF-1 and a novel family member, HCF-2. (PubMed id 10196288)9 Johnson K.M.... Wilson A.C. (J. Virol. 1999)
    192. Retinoblastoma protein expression leads to reduced Oct-1 DNA binding activity and enhances interleukin-8 expression. (PubMed id 10437913)9 Zhang H....Blanck G. (amp 1999)
    193. Maximization of selenocysteine tRNA and U6 small nuclear RNA transcriptional activation achieved by flexible utilization of a Staf zinc finger. (PubMed id 10455183)9 Schaub M....Carbon P. (J. Biol. Chem. 1999)
    194. Glucocorticoids repress transcription from a negative glucocorticoid response element recognized by two homeodomain-containing proteins, Pbx and Oct-1. (PubMed id 9722596)9 Subramaniam N....Okret S. (J. Biol. Chem. 1998)
    195. Coactivation by OCA-B: definition of critical regions and synergism with general cofactors. (PubMed id 9632764)9 Luo Y....Roeder R.G. (Mol. Cell. Biol. 1998)
    196. The Oct-1 POU homeodomain stabilizes the adenovirus preinitiation complex via a direct interaction with the priming protein and is displaced when the replication fork passes. (PubMed id 9013582)9 van Leeuwen H.C....van der Vliet P.C. (J. Biol. Chem. 1997)
    197. Analysis of homeodomain function by structure-based design of a transcription factor. (PubMed id 7568211)9 Pomerantz J.L....Sharp P.A. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    198. Reduced level of octamer binding transcription factor (Oct-1) is correlated with H2B histone gene repression during differentiation of HL-60 cells by all-trans retinoic acid. (PubMed id 7646519)9 Kim K.Y....Lim K. (Biochem. Biophys. Res. Commun. 1995)
    199. The adenovirus DNA binding protein effects the kinetics of DNA replication by a mechanism distinct from NFI or Oct-1. (PubMed id 8441675)9 Mul Y.M. and van der Vliet P.C. (Nucleic Acids Res. 1993)
    200. The herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain. (PubMed id 1684335)9 Stern S. and Herr W. (amp 1991)
    201. Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins. (PubMed id 2216722)9 Schreiber E....Fontana A. (Nucleic Acids Res. 1990)
    202. Tethered-hopping model for protein-DNA binding and unbinding based on Sox2-Oct1-Hoxb1 ternary complex simulations. (PubMed id 20371328)9 Lian P....Wei D. (Biophys. J. 2010)
    203. Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility. (PubMed id 19541747)9 Lu J....Lu D. (FASEB J. 2009)
    204. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) transcriptional regulation by Oct-1 in human endothelial cells: implications for atherosclerosis. (PubMed id 16173915)9 Chen J....Mehta J.L. (Biochem. J. 2006)
    205. Expression profiling of transcription factors Pax-5, Oct-1, Oct-2, BOB.1, and PU.1 in Hodgkin's and non-Hodgkin's lymphomas: a comparative study using high throughput tissue microarrays. (PubMed id 16648862)9 McCune R.C....Vasef M.A. (Mod. Pathol. 2006)
    206. Autoregulation of Oct-1 gene expression is mediated by two octa-sites in alternative promoter. (PubMed id 16716485)9 Pankratova E....Polanovsky O. (Biochimie 2006)
    207. Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-casein. (PubMed id 15798204)9 Inman C.K....Shore P. (Mol. Cell. Biol. 2005)
    208. DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE. (PubMed id 16103132)9 Malin S....Pettersson S. (Nucleic Acids Res. 2005)
    209. Overexpression of octamer transcription factors 1 or 2 alone has no effect on HIV-1 transcription in primary human CD4 T cells. (PubMed id 15051391)9 Zhang M....Cron R.Q. (Virology 2004)
    210. Phylogenetic footprinting reveals evolutionarily conserved regions of the gonadotropin-releasing hormone gene that enhance cell-specific expression. (PubMed id 15319450)9 Givens M.L....Mellon P.L. (Mol. Endocrinol. 2004)
    211. A novel transcriptional element which regulates expression of the CYP2D4 gene by Oct-1 and YY-1 binding. (PubMed id 12818430)9 Mizuno D....Funae Y. (Biochim. Biophys. Acta 2003)
    212. Regulation of human FcepsilonRI beta chain gene expression by Oct- 1. (PubMed id 12697656)9 Akizawa Y.... Ogawa H. (Int. Immunol. 2003)
    213. Involvement of the Oct-1 regulatory element of the gadd45 promoter in the p53-independent response to ultraviolet irradiation. (PubMed id 11221850)9 Takahashi S....Sakai T. (Cancer Res. 2001)
    214. Oct-1 specifically binds the UEF4 site of the human AP1-regulated urokinase enhancer. (PubMed id 10951201)9 Palazzolo M....Blasi F. (Eur. J. Biochem. 2000)
    215. Transcriptional activation of the human hematopoietic prostaglandin D synthase gene in megakaryoblastic cells. Roles of the oct-1 element in the 5'-flanking region and the AP-2 element in the untranslated exon 1. (PubMed id 10998423)9 Fujimori K....Urade Y. (J. Biol. Chem. 2000)
    216. The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAPc largest subunit that bears sequence similarities to the Oct-1 coactivator OBF-1. (PubMed id 9832505)9 Ford E....Hernandez N. (amp 1998)
    217. Oct-1 and CCAAT/enhancer-binding protein (C/EBP) bind to overlapping elements within the interleukin-8 promoter. The role of Oct-1 as a transcriptional repressor. (PubMed id 8999951)9 Wu G.D....Wen X. (J. Biol. Chem. 1997)
    218. Differential in vivo activation of the class II and class III snRNA genes by the POU-specific domain of Oct-1. (PubMed id 9153304)9 Murphy S. (Nucleic Acids Res. 1997)
    219. Abnormality of Oct-1 DNA binding in T cells from SjAPgren's syndrome patients. (PubMed id 8814238)9 Flescher E....Talal N. (Eur. J. Immunol. 1996)
    220. A soluble transcription factor, Oct-1, is also found in the insoluble nuclear matrix and possesses silencing activity in its alanine-rich domain. (PubMed id 8754837)9 Kim M.K....Chung J.H. (Mol. Cell. Biol. 1996)
    221. Oct-1 activates the epithelial-specific enhancer of human papillomavirus type 16 via a synergistic interaction with NFI at a conserved composite regulatory element. (PubMed id 7871754)9 O'Connor M. and Bernard H.U. (Virology 1995)
    222. Mechanisms for flexibility in DNA sequence recognition and VP16-induced complex formation by the Oct-1 POU domain. (PubMed id 7891704)9 Cleary M.A. and Herr W. (Mol. Cell. Biol. 1995)
    223. In vivo and in vitro expression of octamer binding proteins in human melanoma metastases, brain tissue, and fibroblasts. (PubMed id 8502621)9 Thomson J.A....Sturm R.A. (Pigment Cell Res. 1993)
    224. Oct-1 and Oct-2 potentiate functional interactions of a transcription factor with the proximal sequence element of small nuclear RNA genes. (PubMed id 1535687)9 Murphy S....Roeder R.G. (Mol. Cell. Biol. 1992)
    225. A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain. (PubMed id 1358756)9 Lai J.S....Herr W. (amp 1992)
    226. Activation of early gene expression in T lymphocytes by Oct-1 and an inducible protein, OAP40. (PubMed id 1683003)9 Ullman K.S....Crabtree G.R. (Science 1991)
    227. Both Oct-1 and Oct-2A contain domains which can activate the ubiquitously expressed U2 snRNA genes. (PubMed id 1829677)9 Yang J....Pettersson U. (EMBO J. 1991)
    228. Role of alpha-transinducing factor (VP16) in the induction of alpha genes within the context of viral genomes. (PubMed id 1645782)9 Spector D....Roizman B. (J. Virol. 1991)
    229. Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation. (PubMed id 2302733)9 Tanaka M. and Herr W. (Cell 1990)
    230. Mechanisms of SHP-1 P2 promoter regulation in hematopoietic cells and its silencing in HTLV-1-transformed T cells. (PubMed id 18948549)9 Nakase K....Marasco W.A. (J. Leukoc. Biol. 2009)
    231. Glutamate-induced octamer DNA binding and transcriptional control in cultured radial glia cells. (PubMed id 16787415)9 LA^pez-Bayghen E....Ortega A. (J. Neurochem. 2006)
    232. Tat-dependent repression of human immunodeficiency virus type 1 long terminal repeat promoter activity by fusion of cellular transcription factors. (PubMed id 15325274)9 Zhao C....Tang H. (Biochem. Biophys. Res. Commun. 2004)
    233. In silico and in situ characterization of the zebrafish (Danio rerio) gnrh3 (sGnRH) gene. (PubMed id 12188930)9 Torgersen J....AlestrAPm P. (BMC Genomics 2002)
    234. Analysis of octamer-binding transcription factors Oct2 and Oct1 and their coactivator BOB.1/OBF.1 in lymphomas. (PubMed id 11904338)9 SA!ez A.I....Piris M.A. (Mod. Pathol. 2002)
    235. Transcription factors Oct-1 and NF-YA regulate the p53-independent induction of the GADD45 following DNA damage. (PubMed id 11420680)9 Jin S....Zhan Q. (Oncogene 2001)
    236. Octamer proteins inhibit IL-4 gene transcription in normal human CD4 T cells. (PubMed id 11781715)9 Cron R.Q....Lewis D.B. (Genes Immun. 2001)
    237. Conservation of glutamine-rich transactivation function between yeast and humans. (PubMed id 10733580)9 Escher D....Schaffner W. (Mol. Cell. Biol. 2000)
    238. Examination of POU homeobox gene expression in human breast cancer cells. (PubMed id 10077160)9 Jin T....Goss P.E. (Int. J. Cancer 1999)
    239. Binding of YY1 and Oct1 to a novel element that downregulates expression of IL-5 in human T cells. (PubMed id 10359895)9 Mordvinov V.A....Sanderson C.J. (J. Allergy Clin. Immunol. 1999)
    240. Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16. (PubMed id 10398682)9 Liu Y....Cheng X. (amp 1999)
    241. Oct-1 is involved in the transcriptional repression of the von willebrand factor gene promoter. (PubMed id 9694713)9 Schwachtgen J.L....Kerbiriou-Nabias D. (Blood 1998)
    242. Oct-1 promoter region contains octamer sites and TAAT motifs recognized by Oct proteins. (PubMed id 9598983)9 Pankratova E.V....Polanovasky O.L. (FEBS Lett. 1998)
    243. Transcription factor NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes. (PubMed id 9360945)9 Bendall H.H....Oltz E.M. (J. Biol. Chem. 1997)
    244. Correlation of MIB-1 antigen expression with transcription factors Skn-1, Oct-1, AP-2, and HPV type in cervical intraepithelial neoplasia. (PubMed id 9422986)9 Hietala K.A....Kellokoski J.K. (J. Pathol. 1997)
    245. Characterization of constitutive and inducible transcription factors binding to the P2 NF-AT site in the human interleukin-4 promoter. (PubMed id 9133600)9 Li-Weber M....Krammer P.H. (Gene 1997)
    246. Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator OBF-1. (PubMed id 8657574)9 Schubart D.B....Matthias P. (Nucleic Acids Res. 1996)
    247. The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation. (PubMed id 8654375)9 Gstaiger M....Schaffner W. (EMBO J. 1996)
    248. Octamer independent activation of transcription from the kappa immunoglobulin germline promoter. (PubMed id 8972869)9 Prabhu A....Van Ness B. (Nucleic Acids Res. 1996)
    249. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. (PubMed id 7623806)9 Luo Y. and Roeder R.G. (Mol. Cell. Biol. 1995)
    250. Positive and negative regulation of the composite octamer motif of the interleukin 2 enhancer by AP-1, Oct-2, and retinoic acid receptor. (PubMed id 7931079)9 de Grazia U....Gulino A. (J. Exp. Med. 1994)
    251. Cell type- and stage-specific expression of the CD20/B1 antigen correlates with the activity of a diverged octamer DNA motif present in its promoter. (PubMed id 7680653)9 ThAcvenin C....Kehrl J.H. (J. Biol. Chem. 1993)
    252. The adenovirus terminal protein influences binding of replication proteins and changes the origin structure. (PubMed id 8506126)9 Pronk R. and van der Vliet P.C. (Nucleic Acids Res. 1993)
    253. Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. (PubMed id 8234287)9 Bhargava A.K.... Weissman S.M. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    254. Nuclear matrix association of multiple sequence-specific DNA binding activities related to SP-1, ATF, CCAAT, C/EBP, OCT-1, and AP-1. (PubMed id 8357791)9 van Wijnen A.J....Stein G.S. (Biochemistry 1993)
    255. The Oct-1 POU domain mediates interactions between Oct-1 and other POU proteins. (PubMed id 1346336)9 Verrijzer C.P....van der Vliet P.C. (Mol. Cell. Biol. 1992)
    256. Adenovirus DNA replication: the function of the covalently bound terminal protein. (PubMed id 1291241)9 Pronk R....van der Vliet P.C. (Chromosoma 1992)
    257. Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter. (PubMed id 1739980)9 Tanaka M.... Herr W. (Cell 1992)
    258. Transcription factor requirements for U2 snRNA-encoding gene activation in B lymphoid cells. (PubMed id 1765275)9 Janson L. and Pettersson U. (Gene 1991)
    259. The DNA binding domain (POU domain) of transcription factor oct-1 suffices for stimulation of DNA replication. (PubMed id 2347308)9 Verrijzer C.P....Van der Vliet P.C. (EMBO J. 1990)
    260. Genomic organization and regulation of the human orexin (hypocretin) receptor 2 gene: identification of alternative promoters. (PubMed id 20156195)9 Chen J. and Randeva H.S. (Biochem. J. 2010)
    261. Role of defective Oct-2 and OCA-B expression in immunoglobulin production and Kaposi's sarcoma-associated herpesvirus lytic reactivation in primary effusion lymphoma. (PubMed id 19224997)9 Di Bartolo D.L....Cesarman E. (J. Virol. 2009)
    262. Pharmacological inhibition of poly(ADP-ribose) polymerase activity down-regulates the expression of syndecan-4 and Id-1 in endothelial cells. (PubMed id 19212692)9 Lacal P.M....Graziani G. (Int. J. Oncol. 2009)
    263. The POU homeobox protein Oct-1 regulates radial glia formation downstream of Notch signaling. (PubMed id 18241856)9 Kiyota T....Kato Y. (Dev. Biol. 2008)
    264. Transcriptional regulatory network analysis during epithelial-mesenchymal transformation of retinal pigment epithelium. (PubMed id 18682805)9 Pratt C.H....Grunwald G.B. (Mol. Vis. 2008)
    265. Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors. (PubMed id 18654764)9 Glahn F....Foth H. (Arch. Toxicol. 2008)
    266. PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells. (PubMed id 17355223)9 Tan Y.R....Weber H.C. (Biochem. J. 2007)
    267. Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). (PubMed id 17462582)9 Laity J.H. and Andrews G.K. (Arch. Biochem. Biophys. 2007)
    268. Impaired binding of AHSP to alpha chain variants: Hb Groene Hart illustrates a mechanism leading to unstable hemoglobins with alpha thalassemic like syndrome. (PubMed id 17052927)9 Vasseur-Godbillon C....Baudin-Creuza V. (amp 2006)
    269. Molecular mechanism of allergy-related gene regulation and hematopoietic cell development by transcription factors. (PubMed id 16428815)9 Nishiyama C. (Biosci. Biotechnol. Biochem. 2006)
    270. B29 gene silencing in pituitary cells is regulated by its 3' enhancer. (PubMed id 16920149)9 Malone C.S....Wall R. (J. Mol. Biol. 2006)
    271. Identification of transcriptional regulators of neuropeptide FF gene expression. (PubMed id 16515822)9 Nystedt J.M....Panula P. (Peptides 2006)
    272. The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression. (PubMed id 16005513)9 JimAcnez-Mateo O....Castrillo J.L. (Placenta 2006)
    273. Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition. (PubMed id 16754848)9 Tuo J.... Chan C.-C. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    274. Molecular characterization of the Japanese flounder, Paralichthys olivaceus, CD3epsilon and evolution of the CD3 cluster. (PubMed id 15450752)9 Park C.I....Aoki T. (Dev. Comp. Immunol. 2005)
    275. Characterization of two genes encoding leucine-rich repeat-containing proteins in grass carp Ctenopharyngodon idellus. (PubMed id 15578176)9 Chang M.X....Gao Q. (Immunogenetics 2005)
    276. STAT4 expression in human T cells is regulated by DNA methylation but not by promoter polymorphism. (PubMed id 16301617)9 Shin H.J....Lee C.W. (J. Immunol. 2005)
    277. Functional characterization of the sea urchin sns chromatin insulator in erythroid cells. (PubMed id 16185901)9 Acuto S....Spinelli G. (amp 2005)
    278. Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity. (PubMed id 16061936)9 Goffin V....Van Lint C. (Nucleic Acids Res. 2005)
    279. The protein kinase C pathway acts through multiple transcription factors to repress gonadotropin-releasing hormone gene expression in hypothalamic GT1-7 neuronal cells. (PubMed id 15994198)9 Tang Q....Mellon P.L. (Mol. Endocrinol. 2005)
    280. Identification and analysis of the human neural polypyrimidine tract binding protein (nPTB) gene promoter region. (PubMed id 16002244)9 Romanelli M.G....Morandi C. (Gene 2005)
    281. The neuronal host cell factor-binding protein Zhangfei inhibits herpes simplex virus replication. (PubMed id 16282471)9 Akhova O....Misra V. (J. Virol. 2005)
    282. Determination of transcription factors and their possible roles in the regulation of Pax3 gene expression in the mouse B16 F1 melanoma cell line. (PubMed id 16179863)9 Zhu B.K. and Pruitt S.C. (Melanoma Res. 2005)
    283. Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells. (PubMed id 14630700)9 Mackenzie G.G....Oteiza P.I. (FASEB J. 2004)
    284. Repression of gonadotropin-releasing hormone (GnRH) gene expression by melatonin may involve transcription factors COUP-TFI and C/EBP beta binding at the GnRH enhancer. (PubMed id 15004428)9 Gillespie J.M....Belsham D.D. (Neuroendocrinology 2004)
    285. A novel retinoic acid-responsive element regulates retinoic acid-induced BLR1 expression. (PubMed id 14993281)9 Wang J. and Yen A. (Mol. Cell. Biol. 2004)
    286. NF-kappa B and Oct-2 synergize to activate the human 3' Igh hs4 enhancer in B cells. (PubMed id 14707079)9 Sepulveda M.A....Birshtein B.K. (J. Immunol. 2004)
    287. Cell type-specific bidirectional regulation of the glucocorticoid-induced leucine zipper (GILZ) gene by estrogen. (PubMed id 15336700)9 Tynan S.H....Allan G.F. (J. Steroid Biochem. Mol. Biol. 2004)
    288. Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines. (PubMed id 12584750)9 Wang W....Cassidy J. (Int. J. Cancer 2003)
    289. Gene structure of the human metabotropic glutamate receptor 5 and functional analysis of its multiple promoters in neuroblastoma and astroglioma cells. (PubMed id 12783878)9 Corti C....Ferraguti F. (J. Biol. Chem. 2003)
    290. Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells. (PubMed id 12881480)9 Bruemmer D....Law R.E. (Circ. Res. 2003)
    291. Characterization and functional analysis of TFPI-2 gene promoter in a human choriocarcinoma cell line. (PubMed id 12757776)9 Hube F.... Gruel Y. (Thromb. Res. 2003)
    292. Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3. (PubMed id 12752447)9 Liu M....Levy G.A. (Eur. J. Biochem. 2003)
    293. Cloning of a protein binding to the most proximal Pit-1 binding element of prolactin gene from human pituitary cDNA library. (PubMed id 12972181)9 Fumoto M....Chihara K. (Mol. Cell. Endocrinol. 2003)
    294. Transcriptional regulation of osteopontin and the metastatic phenotype: evidence for a Ras-activated enhancer in the human OPN promoter. (PubMed id 12650610)9 Denhardt D.T....Rittling S.R. (amp 2003)
    295. Nitrosative stress and transcription. (PubMed id 14669980)9 KrAPncke K.D. (Biol. Chem. 2003)
    296. Cloning and characterization of the chick Oct binding factor OBF-1. (PubMed id 12359338)9 Takechi S....Nakayama T. (Biochim. Biophys. Acta 2002)
    297. The NFY transcription factor functions as a repressor and activator of the von Willebrand factor promoter. (PubMed id 11895773)9 Peng Y. and Jahroudi N. (Blood 2002)
    298. Oct-2 regulates CD36 gene expression via a consensus octamer, which excludes the co-activator OBF-1. (PubMed id 11937630)9 Shore P....Corcoran L.M. (Nucleic Acids Res. 2002)
    299. Structural and functional characterization of the human PAX7 5'-flanking regulatory region. (PubMed id 12234688)9 Syagailo Y.V....Lesch K.P. (Gene 2002)
    300. Analysis of the promoter region of human mimecan gene. (PubMed id 12020827)9 Tasheva E.S. (Biochim. Biophys. Acta 2002)
    301. An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP. (PubMed id 12271126)9 Luciano R.L. and Wilson A.C. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    302. Stabilization but not the transcriptional activity of herpes simplex virus VP16-induced complexes is evolutionarily conserved among HCF family members. (PubMed id 11711630)9 Lee S. and Herr W. (J. Virol. 2001)
    303. Human ribonucleotide reductase M2 subunit gene amplification and transcriptional regulation in a homogeneous staining chromosome region responsible for the mechanism of drug resistance. (PubMed id 11978967)9 Zhou B....Yen Y. (Cytogenet. Cell Genet. 2001)
    304. Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein. (PubMed id 11384994)9 Zhou H.-J....Jin D.-Y. (J. Biol. Chem. 2001)
    305. Transcriptional regulation of galectin-10 (eosinophil Charcot-Leyden crystal protein): a GC box (-44 to -50) controls butyric acid induction of gene expression. (PubMed id 11441910)9 Dyer K.D. and Rosenberg H.F. (Life Sci. 2001)
    306. The core promoter of human thioredoxin reductase 1: cloning, transcriptional activity, and Oct-1, Sp1, and Sp3 binding reveal a housekeeping-type promoter for the AU-rich element-regulated gene. (PubMed id 11375392)9 RundlAPf A.K....ArnAcr E.S. (J. Biol. Chem. 2001)
    307. Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene. (PubMed id 11707336)9 Minekura H....Yamamoto T.T. (Gene 2001)
    308. Cellular transcription factors that interact with p6 promoter elements of parvovirus B19. (PubMed id 11369893)9 Raab U....Modrow S. (J. Gen. Virol. 2001)
    309. Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation. (PubMed id 11533238)9 Osborne A....Blanck G. (Mol. Cell. Biol. 2001)
    310. Novel control motif cluster in the IgH delta-gamma 3 interval exhibits B cell-specific enhancer function in early development. (PubMed id 11207287)9 Mundt C.A....BrA1ggemann M. (J. Immunol. 2001)
    311. Transcriptional regulation of IL-5 gene by nontransformed human T cells through the proximal promoter element. (PubMed id 10939534)9 Mori A....Akiyama K. (Intern. Med. 2000)
    312. Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription. (PubMed id 10828057)9 Wolstein O.... Dikstein R. (J. Biol. Chem. 2000)
    313. Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4. (PubMed id 10623541)9 Turgeon D....Hum D.W. (J. Mol. Biol. 2000)
    314. Transcription factors Oct-1 and C/EBPbeta (CCAAT/enhancer-binding protein-beta) are involved in the glutamate/nitric oxide/cyclic-guanosine 5'-monophosphate-mediated repression of mediated repression of gonadotropin-releasing hormone gene expression. (PubMed id 10674395)9 Belsham D.D. and Mellon P.L. (Mol. Endocrinol. 2000)
    315. Cutting edge: lack of peripheral B cells and severe agammaglobulinemia in mice simultaneously lacking Bruton's tyrosine kinase and the B cell-specific transcriptional coactivator OBF-1. (PubMed id 10604987)9 Schubart D.B....Matthias P. (J. Immunol. 2000)
    316. In vivo protein-DNA interactions at the kinin B(1) receptor gene promoter: no modification on interleukin-1 beta or lipopolysaccharide induction. (PubMed id 10842322)9 Angers M....Bachvarov D.R. (J. Cell. Biochem. 2000)
    317. Identification of cis-acting DNA elements required for expression of the human cardiac troponin I gene promoter. (PubMed id 10652194)9 Bhavsar P.K....Barton P.J. (J. Mol. Cell. Cardiol. 2000)
    318. Activation of the transcription factor Oct-1 in response to DNA damage. (PubMed id 11103783)9 Zhao H....Zhan Q. (Cancer Res. 2000)
    319. Ku autoantigen: a multifunctional DNA-binding protein. (PubMed id 10755664)9 Tuteja R. and Tuteja N. (Crit. Rev. Biochem. Mol. Biol. 2000)
    320. Delivery and expression of fluid shear stress-inducible promoters to the vessel wall: applications for cardiovascular gene therapy. (PubMed id 10609662)9 Houston P....Braddock M. (Hum. Gene Ther. 1999)
    321. Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding. (PubMed id 10329190)9 Chang J.F....Luisi B. (J. Mol. Biol. 1999)
    322. Trichostatin A up-regulates human papillomavirus type 11 upstream regulatory region-E6 promoter activity in undifferentiated primary human keratinocytes. (PubMed id 10233965)9 Zhao W....Broker T.R. (J. Virol. 1999)
    323. POU family transcription factors in the nervous system. (PubMed id 10199551)9 Latchman D.S. (J. Cell. Physiol. 1999)
    324. Mechanism of DNA replication in eukaryotic cells: cellular host factors stimulating adenovirus DNA replication. (PubMed id 10433960)9 de Jong R.N. and van der Vliet P.C. (Gene 1999)
    325. Ionizing radiation stimulates octamer factor DNA binding activity in human carcinoma cells. (PubMed id 10544969)9 Meighan-Mantha R.L....Kasid U. (Mol. Cell. Biochem. 1999)
    326. [Functional analysis of human A gamma-globin gene promoter with-173 T--&gt;C mutation]. (PubMed id 12567445)9 Huang X....Zhao H. (Zhongguo Yi Xue Ke Xue Yuan Xue Bao 1999)
    327. The activity of the human interleukin-5 conserved lymphokine element 0 is regulated by octamer factors in human cells. (PubMed id 10491186)9 Thomas M.A....Sanderson C.J. (Eur. J. Biochem. 1999)
    328. Involvement of simultaneous multiple transcription factor expression, including cAMP responsive element binding protein and OCT-1, for synovial cell outgrowth in patients with rheumatoid arthritis. (PubMed id 9797555)9 Wakisaka S....Sakane T. (Ann. Rheum. Dis. 1998)
    329. Acquisition of cellular resistance to 9-nitro-camptothecin correlates with suppression of transcription factor NF-kappa B activation and potentiation of cytotoxicity by tumor necrosis factor in human histiocytic lymphoma U-937 cells. (PubMed id 9823429)9 Singh S....Aggarwal B.B. (Anticancer Drugs 1998)
    330. The small GTP-binding protein Rho potentiates AP-1 transcription in T cells. (PubMed id 9710582)9 Chang J.H....Burakoff S.J. (Mol. Cell. Biol. 1998)
    331. Five discrete cis-active domains direct cell type-specific transcription of the vasoactive intestinal peptide (VIP) gene. (PubMed id 9642274)9 Hahm S.H. and Eiden L.E. (J. Biol. Chem. 1998)
    332. Identification of conserved potentially regulatory sequences of the SRY gene from 10 different species of mammals. (PubMed id 9571157)9 Margarit E....Oliva R. (Biochem. Biophys. Res. Commun. 1998)
    333. MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis. (PubMed id 9721210)9 Fenner M.H....Shioda T. (Genomics 1998)
    334. GATA-1 DNA binding activity is down-regulated in late S phase in erythroid cells. (PubMed id 8999960)9 Cullen M.E. and Patient R.K. (J. Biol. Chem. 1997)
    335. The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat. (PubMed id 9078256)9 Liu Y.Z. and Latchman D.S. (Biochem. J. 1997)
    336. Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB. (PubMed id 9348104)9 Lyss G....Pahl H.L. (Biol. Chem. 1997)
    337. Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1. (PubMed id 9376596)9 Tsukada J....Eto S. (Blood 1997)
    338. Identification of cis-regulatory elements in the upstream regulatory region of human papillomavirus type 59. (PubMed id 9085547)9 Rho J....Choe J. (Virus Res. 1997)
    339. Characterization of Skn-1a/i POU domain factors and linkage to papillomavirus gene expression. (PubMed id 9188490)9 Andersen B....Rosenfeld M.G. (J. Biol. Chem. 1997)
    340. Reversible activation of mouse metal response element-binding transcription factor 1 DNA binding involves zinc interaction with the zinc finger domain. (PubMed id 9111349)9 Dalton T.P....Andrews G.K. (Mol. Cell. Biol. 1997)
    341. Cysteine 50 of the POU H domain determines the range of targets recognized by POU proteins. (PubMed id 9207034)9 Stepchenko A.G....Pankratova E.V. (Nucleic Acids Res. 1997)
    342. Mutation in an alpha1-antitrypsin enhancer results in an interleukin-6 deficient acute-phase response due to loss of cooperativity between transcription factors. (PubMed id 9434101)9 Morgan K....Kalsheker N.A. (Biochim. Biophys. Acta 1997)
    343. Proteasome regulation of Fas ligand cytotoxicity. (PubMed id 9341769)9 Matsui K....Ju S.T. (Eur. J. Immunol. 1997)
    344. VP16 targets an amino-terminal domain of HCF involved in cell cycle progression. (PubMed id 9315674)9 Wilson A.C....Herr W. (Mol. Cell. Biol. 1997)
    345. Transcriptional regulation of the human replacement histone gene H3.3B. (PubMed id 9188772)9 Witt O....Doenecke D. (FEBS Lett. 1997)
    346. Effects of oxidation and reduction on the binding of transcription factors to cis-regulatory elements located in the FGF-4 gene. (PubMed id 9115711)9 Lickteig K....Rizzino A. (Mol. Reprod. Dev. 1996)
    347. Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization. (PubMed id 8617501)9 Junker S....Tommerup N. (Genomics 1996)
    348. Prostaglandin E2 inhibits the interleukin-2 promoter activity through down-regulation of the Oct-dependent transcription of the octamer motif. (PubMed id 8964085)9 Felli M.P....Gulino A. (Cell. Immunol. 1996)
    349. Transcriptional activation by Oct-3: evidence for a specific role of the POU-specific domain in mediating functional interaction with Oct-1. (PubMed id 8668543)9 Vigano M.A. and Staudt L.M. (Nucleic Acids Res. 1996)
    350. Sequence-specific DNA binding of the B-cell-specific coactivator OCA-B. (PubMed id 8769650)9 Cepek K.L....Sharp P.A. (amp 1996)
    351. Interaction of the Ubc9 human homologue with c-Jun and with the glucocorticoid receptor. (PubMed id 8733011)9 GAPttlicher M....Herrlich P. (Steroids 1996)
    352. Structure, organization, and transcription units of the human alpha- platelet-derived growth factor receptor gene, PDGFRA. (PubMed id 8586421)9 Kawagishi J. and Ku T. (Genomics 1995)
    353. M-phase-specific phosphorylation of the POU transcription factor GHF-1 by a cell cycle-regulated protein kinase inhibits DNA binding. (PubMed id 8524234)9 Caelles C....Karin M. (Mol. Cell. Biol. 1995)
    354. Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. (PubMed id 7721885)9 Wang P....Billah M.M. (J. Biol. Chem. 1995)
    355. Phosphorylation of transcription factors and control of the cell cycle. (PubMed id 7549180)9 Boulikas T. (Crit. Rev. Eukaryot. Gene Expr. 1995)
    356. Involvement of the Ets family factor PU.1 in the activation of immunoglobulin promoters. (PubMed id 7822329)9 Schwarzenbach H....Matthias P. (J. Biol. Chem. 1995)
    357. Down regulation of the octamer binding protein Oct-1 during growth arrest and differentiation of a neuronal cell line. (PubMed id 7707877)9 Lakin N.D....Latchman D.S. (Brain Res. Mol. Brain Res. 1995)
    358. Pleiotropic effects of Bcl-2 on transcription factors in T cells: potential role of NF-kappa B p50-p50 for the anti-apoptotic function of Bcl-2. (PubMed id 8580069)9 Ivanov V.N....Malek T.R. (Int. Immunol. 1995)
    359. Transcriptional activity of human papillomavirus type 31b enhancer is regulated through synergistic interaction of AP1 with two novel cellular factors. (PubMed id 7645210)9 Kyo S....Laimins L.A. (Virology 1995)
    360. The C-terminus of the B cell activator Oct-2 functions as an activation domain in yeast. (PubMed id 7811293)9 Mead J....Ludmerer S.W. (Biochem. Biophys. Res. Commun. 1994)
    361. Transcriptional activation by the human cytomegalovirus immediate-early proteins: requirements for simple promoter structures and interactions with multiple components of the transcription complex. (PubMed id 8035517)9 Lukac D.M....Alwine J.C. (J. Virol. 1994)
    362. Assembly and DNA binding of recombinant Ku (p70/p80) autoantigen defined by a novel monoclonal antibody specific for p70/p80 heterodimers. (PubMed id 7699019)9 Wang J....Reeves W.H. (J. Cell. Sci. 1994)
    363. The Oct-2 glutamine-rich and proline-rich activation domains can synergize with each other or duplicates of themselves to activate transcription. (PubMed id 8065338)9 Tanaka M....Herr W. (Mol. Cell. Biol. 1994)
    364. Transcriptional synergism between the vitamin D3 receptor and other nonreceptor transcription factors. (PubMed id 7708050)9 Liu M. and Freedman L.P. (Mol. Endocrinol. 1994)
    365. trans activation by the full-length E2 proteins of human papillomavirus type 16 and bovine papillomavirus type 1 in vitro and in vivo: cooperation with activation domains of cellular transcription factors. (PubMed id 8083999)9 Ushikai M....Davidson I. (J. Virol. 1994)
    366. A nonconsensus octamer-recognition sequence (TAATGARAT-motif) identifies a novel DNA binding protein in human Merkel cell carcinoma cell lines. (PubMed id 8026890)9 Thomson J.A....Parsons P.G. (Int. J. Cancer 1994)
    367. Control of DNA replication by protein phosphorylation. (PubMed id 7872668)9 Boulikas T. (Anticancer Res. 1994)
    368. Gene transcription in differentiating immature T cell receptor(neg) thymocytes resembles antigen-activated mature T cells. (PubMed id 8376926)9 ZA_A+iga-PflA1cker J.C....Lenardo M.J. (J. Exp. Med. 1993)
    369. Specific cleavage of transcription factors by the thiol protease, m-calpain. (PubMed id 8255762)9 Watt F. and Molloy P.L. (Nucleic Acids Res. 1993)
    370. Chromosomal organization of the gene encoding porcine antileukoproteinase and functional analysis of the promoter region in endometrial and placental cells. (PubMed id 7908270)9 Simmen R.C....Michel F.J. (Mol. Cell. Endocrinol. 1993)
    371. Specific transcriptional activation in vitro by the herpes simplex virus protein VP16. (PubMed id 8284200)9 Arnosti D.N....Luisi B.F. (Nucleic Acids Res. 1993)
    372. Molecular basis for developmental changes in interleukin-2 gene inducibility. (PubMed id 8417328)9 Chen D. and Rothenberg E.V. (Mol. Cell. Biol. 1993)
    373. Different activation domains stimulate transcription from remote ('enhancer') and proximal ('promoter') positions. (PubMed id 1464321)9 Seipel K....Schaffner W. (EMBO J. 1992)
    374. Functional interference between the ubiquitous and constitutive octamer transcription factor 1 (OTF-1) and the glucocorticoid receptor by direct protein-protein interaction involving the homeo subdomain of OTF-1. (PubMed id 1406672)9 Kutoh E....Poellinger L. (Mol. Cell. Biol. 1992)
    375. Identification of sites for distinct DNA binding proteins including Oct-1 and Oct-2 in the Cr2 gene. (PubMed id 1534100)9 Christensen S.M....Weis J.H. (J. Immunol. 1992)
    376. A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells. (PubMed id 1383937)9 Lillycrop K.A....Latchman D.S. (Nucleic Acids Res. 1992)
    377. The weak, fine-tuned binding of ubiquitous transcription factors to the Il-2 enhancer contributes to its T cell-restricted activity. (PubMed id 1614851)9 Hentsch B....Serfling E. (Nucleic Acids Res. 1992)
    378. Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations. (PubMed id 1495986)9 Lai J.S. and Herr W. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    379. Okadaic acid is a potent inducer of AP-1, NF-kappa B, and tumor necrosis factor-alpha in human B lymphocytes. (PubMed id 1520341)9 Rieckmann P....Kehrl J.H. (Biochem. Biophys. Res. Commun. 1992)
    380. Recognition of the surface of a homeo domain protein. (PubMed id 1358755)9 Pomerantz J.L....Sharp P.A. (amp 1992)

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    Entrez Gene: 5451 HGNC: 9212 AceView: POU2F1 Ensembl:ENSG00000143190 euGenes: HUgn5451
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