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Aliases for POU2F1 Gene

Aliases for POU2F1 Gene

  • POU Class 2 Homeobox 1 2 3 5
  • Octamer-Binding Transcription Factor 1 3 4
  • Octamer-Binding Protein 1 3 4
  • Oct-1 3 4
  • NF-A1 3 4
  • OTF-1 3 4
  • OTF1 3 4
  • OCT1 3 4
  • POU Domain, Class 2, Transcription Factor 1 3
  • POU Domain Class 2, Transcription Factor 1 2
  • Octamer-Binding Transcription Factor-1 3
  • Oct-1B 3

External Ids for POU2F1 Gene

Previous HGNC Symbols for POU2F1 Gene

  • OTF1

Previous GeneCards Identifiers for POU2F1 Gene

  • GC01P164826
  • GC01P162840
  • GC01P163886
  • GC01P164377
  • GC01P163921
  • GC01P165456
  • GC01P138436

Summaries for POU2F1 Gene

Entrez Gene Summary for POU2F1 Gene

  • The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]

GeneCards Summary for POU2F1 Gene

POU2F1 (POU Class 2 Homeobox 1) is a Protein Coding gene. Diseases associated with POU2F1 include Herpes Simplex and Primary Amebic Meningoencephalitis. Among its related pathways are Development_Glucocorticoid receptor signaling and Immune System. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is POU2F2.

UniProtKB/Swiss-Prot for POU2F1 Gene

  • Transcription factor that binds to the octamer motif (5-ATTTGCAT-3) and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.

Gene Wiki entry for POU2F1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU2F1 Gene

Genomics for POU2F1 Gene

Regulatory Elements for POU2F1 Gene

Enhancers for POU2F1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F167267 1.2 Ensembl ENCODE 11.8 +47.4 47372 1.2 HDGF ATF1 PKNOX1 ZNF2 CBX5 ZNF143 JUNB REST KAT8 SMARCA4 POU2F1 CREG1 TADA1 GC01P167371
GH01F167262 1.1 Ensembl ENCODE 11.9 +43.1 43072 2.6 PKNOX1 FEZF1 ZNF121 ZNF366 SCRT2 OVOL3 TSHZ1 ZNF623 ZNF843 RAD51 POU2F1 CREG1 GC01P167371
GH01F167249 1.1 Ensembl ENCODE 11.4 +28.8 28818 0.5 PKNOX1 TBL1XR1 PTRF CHAMP1 GATA2 TBX21 CREB3 MEF2D SMARCA4 PBX2 POU2F1 GC01P167371
GH01F167066 1.1 Ensembl ENCODE 11.4 -154.0 -154029 0.8 CBX3 ZFP64 ZNF48 ZNF2 RAD21 ZNF143 MCM3 ZNF654 REST ZEB2 GPA33 DUSP27 POU2F1 ILDR2 MAEL LOC105371600 LOC105371598
GH01F167251 0.9 ENCODE 11.4 +30.9 30910 0.2 TBP HDGF SREBF2 SIN3A YY1 KAT2B ZNF766 ZNF391 KDM4B ZHX1 POU2F1 GC01P167371
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POU2F1 on UCSC Golden Path with GeneCards custom track

Promoters for POU2F1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000547018 171 3601 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for POU2F1 Gene

Chromosome:
1
Start:
167,220,829 bp from pter
End:
167,427,345 bp from pter
Size:
206,517 bases
Orientation:
Plus strand

Genomic View for POU2F1 Gene

Genes around POU2F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POU2F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POU2F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU2F1 Gene

Proteins for POU2F1 Gene

  • Protein details for POU2F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14859-PO2F1_HUMAN
    Recommended name:
    POU domain, class 2, transcription factor 1
    Protein Accession:
    P14859
    Secondary Accessions:
    • B1AL91
    • B1AL93
    • B4E029
    • J3KP77
    • Q5TBT7
    • Q6PK46
    • Q8NEU9
    • Q9BPV1

    Protein attributes for POU2F1 Gene

    Size:
    743 amino acids
    Molecular mass:
    76472 Da
    Quaternary structure:
    • Interacts with NR3C1, AR, PGR and HCFC1. Associates with the herpes simplex virus VP16-induced complex; binding to HCFC1 activates the viral transcriptional activator VP16 for association with POU2F1, to form a multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes.

    Three dimensional structures from OCA and Proteopedia for POU2F1 Gene

    Alternative splice isoforms for POU2F1 Gene

neXtProt entry for POU2F1 Gene

Post-translational modifications for POU2F1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for POU2F1 (1-Oct)
  • Cloud-Clone Corp. Antibodies for POU2F1

No data available for DME Specific Peptides for POU2F1 Gene

Domains & Families for POU2F1 Gene

Gene Families for POU2F1 Gene

Graphical View of Domain Structure for InterPro Entry

P14859

UniProtKB/Swiss-Prot:

PO2F1_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the POU transcription factor family. Class-2 subfamily.
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 POU-specific domain.
Family:
  • Belongs to the POU transcription factor family. Class-2 subfamily.
genes like me logo Genes that share domains with POU2F1: view

Function for POU2F1 Gene

Molecular function for POU2F1 Gene

GENATLAS Biochemistry:
POU domain,class 2,transcription factor 1
UniProtKB/Swiss-Prot Function:
Transcription factor that binds to the octamer motif (5-ATTTGCAT-3) and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.

Gene Ontology (GO) - Molecular Function for POU2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 10629049
GO:0043565 sequence-specific DNA binding IEA,IDA 7945330
genes like me logo Genes that share ontologies with POU2F1: view
genes like me logo Genes that share phenotypes with POU2F1: view

Animal Models for POU2F1 Gene

MGI Knock Outs for POU2F1:

Animal Model Products

miRNA for POU2F1 Gene

miRTarBase miRNAs that target POU2F1

Transcription Factor Targets for POU2F1 Gene

Selected GeneGlobe predicted Target genes for POU2F1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for POU2F1 Gene

Localization for POU2F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU2F1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POU2F1 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for POU2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9242494
GO:0005654 nucleoplasm IDA,TAS --
GO:0005783 endoplasmic reticulum IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with POU2F1: view

Pathways & Interactions for POU2F1 Gene

genes like me logo Genes that share pathways with POU2F1: view

SIGNOR curated interactions for POU2F1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for POU2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
GO:0045892 negative regulation of transcription, DNA-templated IDA 11891224
genes like me logo Genes that share ontologies with POU2F1: view

Drugs & Compounds for POU2F1 Gene

(6) Drugs for POU2F1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for POU2F1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with POU2F1: view

Transcripts for POU2F1 Gene

Unigene Clusters for POU2F1 Gene

POU class 2 homeobox 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POU2F1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - - - - -
SP4: -
SP5: - - - - -
SP6:
SP7: - - - - - - - - - - - -
SP8: -
SP9: - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - -
SP12:

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24
SP1:
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7: - - -
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for POU2F1 Gene

GeneLoc Exon Structure for
POU2F1
ECgene alternative splicing isoforms for
POU2F1

Expression for POU2F1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POU2F1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POU2F1 Gene

This gene is overexpressed in Stomach (22.2), Blymphocyte (10.3), Pancreas (8.1), and Skin (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POU2F1 Gene



Protein tissue co-expression partners for POU2F1 Gene

NURSA nuclear receptor signaling pathways regulating expression of POU2F1 Gene:

POU2F1

SOURCE GeneReport for Unigene cluster for POU2F1 Gene:

Hs.283402

mRNA Expression by UniProt/SwissProt for POU2F1 Gene:

P14859-PO2F1_HUMAN
Tissue specificity: Ubiquitous. Isoform 2 is lymphocyte-specific.
genes like me logo Genes that share expression patterns with POU2F1: view

Primer Products

No data available for mRNA differential expression in normal tissues for POU2F1 Gene

Orthologs for POU2F1 Gene

This gene was present in the common ancestor of animals.

Orthologs for POU2F1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POU2F1 34 35
  • 99.64 (n)
cow
(Bos Taurus)
Mammalia POU2F1 34 35
  • 93 (n)
oppossum
(Monodelphis domestica)
Mammalia POU2F1 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POU2F1 34 35
  • 91.36 (n)
rat
(Rattus norvegicus)
Mammalia Pou2f1 34
  • 91.34 (n)
mouse
(Mus musculus)
Mammalia Pou2f1 34 16 35
  • 90.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia POU2F1 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHOCT-1 35
  • 96 (a)
OneToOne
POU2F1 34
  • 88.96 (n)
lizard
(Anolis carolinensis)
Reptilia POU2F1 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pou2f1 34
  • 80.84 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1265 34
zebrafish
(Danio rerio)
Actinopterygii pou2f1b 34 35
  • 70.79 (n)
oct1 34
fruit fly
(Drosophila melanogaster)
Insecta nub 36 35
  • 75 (a)
pdm2 36 35
  • 73 (a)
worm
(Caenorhabditis elegans)
Secernentea ceh-18 35
  • 27 (a)
OneToMany
Species where no ortholog for POU2F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POU2F1 Gene

ENSEMBL:
Gene Tree for POU2F1 (if available)
TreeFam:
Gene Tree for POU2F1 (if available)

Paralogs for POU2F1 Gene

(16) SIMAP similar genes for POU2F1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with POU2F1: view

Variants for POU2F1 Gene

Sequence variations from dbSNP and Humsavar for POU2F1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035816 A breast cancer sample
rs10047122 -- 167,231,609(+) AATGT(A/G)CTGAG intron-variant
rs10082006 -- 167,221,926(+) CAGCC(C/T)CTTTG intron-variant
rs10082074 -- 167,312,298(+) ggcac(A/G)atctc intron-variant
rs10082118 -- 167,221,683(+) CGGCC(G/T)CGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POU2F1 Gene

Variant ID Type Subtype PubMed ID
nsv831814 CNV loss 17160897
nsv831803 CNV loss 17160897
nsv521232 CNV gain+loss 19592680
nsv3432 CNV insertion 18451855
nsv3421 CNV insertion 18451855
nsv1113191 CNV deletion 24896259
nsv1078878 OTHER inversion 25765185
nsv1078309 CNV deletion 25765185
nsv1014857 CNV gain 25217958
nsv1000229 CNV loss 25217958
esv3890749 CNV gain 25118596
esv2719195 CNV deletion 23290073

Variation tolerance for POU2F1 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POU2F1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POU2F1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU2F1 Gene

Disorders for POU2F1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for POU2F1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
primary amebic meningoencephalitis
  • naegleria fowleri infection
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POU2F1

Genetic Association Database (GAD)
POU2F1
Human Genome Epidemiology (HuGE) Navigator
POU2F1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POU2F1
genes like me logo Genes that share disorders with POU2F1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POU2F1 Gene

Publications for POU2F1 Gene

  1. Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1. (PMID: 14612514) Schild-Poulter C. … Hache R.J.G. (Cancer Res. 2003) 3 4 22 64
  2. Differential phosphorylation of the transcription factor Oct1 during the cell cycle. (PMID: 1887216) Roberts S.B. … Heintz N. (Science 1991) 2 3 22 64
  3. Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. (PMID: 1684878) Segil N. … Heintz N. (Science 1991) 3 4 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. (PMID: 20886065) Cleynen I. … Vermeire S. (PLoS ONE 2010) 3 46 64

Products for POU2F1 Gene

Sources for POU2F1 Gene

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