Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU2AF1 Gene

protein-coding   GIFtS: 55
GCID: GC11M111222

POU Class 2 Associating Factor 1

(Previous names: POU domain class 2, associating factor 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
POU Class 2 Associating Factor 11 2     POU Domain Class 2, Associating Factor 11
OBF12 3 5     BOB12
BOB-12 3     OBF-12
OCA-B2 3     OCAB2
B-Cell-Specific Coactivator OBF-12 3     POU Domain Class 2-Associating Factor 12
OCT-Binding Factor 12 3     POU Domain, Class 2, Associating Factor 12

External Ids:    HGNC: 92111   Entrez Gene: 54502   Ensembl: ENSG000001107777   OMIM: 6012065   UniProtKB: Q166333   

Export aliases for POU2AF1 gene to outside databases

Previous GC identifers: GC11M113575 GC11M112735 GC11M111256 GC11M110760 GC11M110728 GC11M107147


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for POU2AF1 Gene: 
POU2AF1 (POU class 2 associating factor 1) is a protein-coding gene. Diseases associated with POU2AF1 include primary effusion lymphoma, and mediastinitis. GO annotations related to this gene include transcription coactivator activity and transcription cofactor activity.

UniProtKB/Swiss-Prot: OBF1_HUMAN, Q16633
Function: Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1
mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It
recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required
for the formation of germinal centers

Gene Wiki entry for POU2AF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU2AF1 gene promoter:
         TBP   AML1a   MyoD   HNF-3beta   POU3F2   C/EBPalpha   FOXL1   c-Ets-1   MEF-2A   CHOP-10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): POU2AF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for POU2AF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU2AF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q23.1

POU2AF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU2AF1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M111222:  view genomic region     (about GC identifiers)

Start:
111,222,977 bp from pter      End:
111,326,355 bp from pter
Size:
103,379 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OBF1_HUMAN, Q16633 (See protein sequence)
Recommended Name: POU domain class 2-associating factor 1  
Size: 256 amino acids; 27436 Da
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for POU2AF1:
1CQT (3D)    
Secondary accessions: B2R8Z9 Q14983

Explore the universe of human proteins at neXtProt for POU2AF1: NX_Q16633

Post-translational modifications:

  • UniProtKB: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (Probable)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16633

  • POU2AF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_006226.2  
    ENSEMBL proteins: 
     ENSP00000376786   ENSP00000433527  

    Human Recombinant Protein Products for POU2AF1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for POU2AF1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for POU2AF1
    GenScript Custom Purified and Recombinant Proteins Services for POU2AF1
    Novus Biologicals POU2AF1 Proteins
    Novus Biologicals POU2AF1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for POU2AF1
    Cloud-Clone Corp. Proteins for POU2AF1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    POU2AF1 for ontologies           About GeneDecksing



    POU2AF1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for POU2AF1
    OriGene Custom Antibody Services for POU2AF1
    GenScript Custom Superior Antibodies Services for POU2AF1
    Novus Biologicals POU2AF1 Antibodies
    Abcam antibodies for POU2AF1
    Cloud-Clone Corp. Antibodies for POU2AF1 
    ThermoFisher Antibody for POU2AF1
    LSBio Antibodies in human, mouse, rat for POU2AF1 

    Assay Products for POU2AF1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for POU2AF1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POU2AF1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for POU2AF1 
    Cloud-Clone Corp. CLIAs for POU2AF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR015389 PD-C2-AF1

    Graphical View of Domain Structure for InterPro Entry Q16633

    ProtoNet protein and cluster: Q16633

    UniProtKB/Swiss-Prot: OBF1_HUMAN, Q16633
    Similarity: Belongs to the POU2AF1 family


    POU2AF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OBF1_HUMAN, Q16633
    Function: Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1
    mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It
    recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required
    for the formation of germinal centers

         Genatlas biochemistry entry for POU2AF1:
    POU domain class 2,associating factor 1,B-cell specific coactivator,specifically associating with OCT1 (OTF1) and
    OCT2,fused with LAZ3/BCL6 in a B-cell leukemia cell line (Karpas 231)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003712transcription cofactor activity TAS7859290
    GO:0003713transcription coactivator activity TAS7859290
    GO:0005515protein binding ----
         
    POU2AF1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for POU2AF1:
     Increased G1 DNA content 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pou2af1):
     cellular  growth/size  hematopoietic system  immune system  mortality/aging 
     renal/urinary system 

    POU2AF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for POU2AF1: Pou2af1tm1Pjln Pou2af1tm1Pmt Pou2af1tm1Rgr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for POU2AF1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POU2AF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU2AF1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU2AF1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU2AF1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate POU2AF1 (see all 10):
    hsa-miR-3128 hsa-miR-4251 hsa-miR-4318 hsa-miR-545 hsa-miR-766 hsa-miR-3142 hsa-miR-1252 hsa-miR-3126-3p
    SwitchGear 3'UTR luciferase reporter plasmidPOU2AF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for POU2AF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU2AF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for POU2AF1
    Sirion Biotech Customized adenovirus for overexpression of POU2AF1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for POU2AF1 (see all 7)
    OriGene ORF clones in mouse, rat for POU2AF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POU2AF1 (NM_006235)
    Sino Biological Human cDNA Clone for POU2AF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU2AF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU2AF1
    Sirion Biotech Customized lentivirus for stable overexpression of POU2AF1 
                         Customized lentivirus expression plasmids for stable overexpression of POU2AF1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for POU2AF1
    Search LifeMap BioReagents cell lines for POU2AF1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2AF1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU2AF1

    5/15 Interacting proteins for POU2AF1 (Q166333) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYKP434053I2D: score=4 
    SIAH1Q8IUQ43I2D: score=3 
    SUB1P539993I2D: score=3 
    POU2F1P148593I2D: score=2 
    POU2F2P090863I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS7859290
    GO:0006959humoral immune response TAS7859290

    POU2AF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POU2AF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POU2AF1 (OBF1)

    1 Novoseek inferred chemical compound relationship for POU2AF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 2 10604987 (2)

    Search CenterWatch for drugs/clinical trials and news about POU2AF1 / OBF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POU2AF1 gene: 
    NM_006235.2  

    Unigene Cluster for POU2AF1:

    POU class 2 associating factor 1
    Hs.654525  [show with all ESTs]
    Unigene Representative Sequence: Z49194
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393067(uc001plg.4) ENST00000525584 ENST00000531398 ENST00000530793
    ENST00000525662 ENST00000526535 ENST00000525499 ENST00000515029(uc001plh.1)
    ENST00000530229 ENST00000525527 ENST00000529065 ENST00000525890
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU2AF1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate POU2AF1 (see all 10):
    hsa-miR-3128 hsa-miR-4251 hsa-miR-4318 hsa-miR-545 hsa-miR-766 hsa-miR-3142 hsa-miR-1252 hsa-miR-3126-3p
    SwitchGear 3'UTR luciferase reporter plasmidPOU2AF1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for POU2AF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU2AF1
    Clone
    Products:
         
    OriGene clones in human, mouse for POU2AF1 (see all 7)
    OriGene ORF clones in mouse, rat for POU2AF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POU2AF1 (NM_006235)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU2AF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU2AF1
    Sirion Biotech Customized lentivirus for stable overexpression of POU2AF1 
                         Customized lentivirus expression plasmids for stable overexpression of POU2AF1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for POU2AF1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POU2AF1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU2AF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU2AF1

    Additional mRNA sequence: 

    AK313573.1 BC032549.1 X83504.1 Z47550.1 Z49194.1 

    4 DOTS entries:

    DT.97858926  DT.208246  DT.99962992  DT.92427082 

    24/64 AceView cDNA sequences (see all 64):

    BM795830 BX462387 X83504 BF510638 Z47550 AA362508 BX443224 CR599556 
    AI888552 BQ423501 AA928017 AL560547 BM464990 AW207472 AW407993 CF121528 
    BM464708 AW663547 BG757562 BX445716 NM_006235 AW405850 BX479626 BX342926 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU2AF1 expression in normal human tissues (normalized intensities)      POU2AF1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTTTCTG
    POU2AF1 Expression
    About this image


    POU2AF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Lymph (Hematopoietic System)    fully expand to see all 4 entries
             lymph node ; non-germinal center cells   
             LYMPH NODE   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             colon ; peripheral nerve/ganglion   

    Genevestigator expression for POU2AF1

    SOURCE GeneReport for Unigene cluster: Hs.654525

    UniProtKB/Swiss-Prot: OBF1_HUMAN, Q16633
    Tissue specificity: B-cell specific

        SABiosciences Expression via Pathway-Focused PCR Arrays including POU2AF1: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Transcription Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for POU2AF1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POU2AF1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU2AF1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU2AF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2AF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for POU2AF1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou2af11 , 5 POU domain, class 2, associating factor 11, 5 86.33(n)1
    89.45(a)1
      9 (27.95 cM)5
    189851  NM_011136.21  NP_035266.11 
     512136905 
    chicken
    (Gallus gallus)
    Aves POU2AF11 POU class 2 associating factor 1 71.54(n)
    66.8(a)
      373994  NM_204175.2  NP_989506.1 
    lizard
    (Anolis carolinensis)
    Reptilia POU2AF16
    POU class 2 associating factor 1
    57(a)
    1 ↔ 1
    GL343521.1(323530-349032)


    ENSEMBL Gene Tree for POU2AF1 (if available)
    TreeFam Gene Tree for POU2AF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/678 SNPs in POU2AF1 are shown (see all 678)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1387928681,2
    --111222482(+) AAGAAA/GTGAAA 1 -- ds50010--------
    rs1829962071,2
    --111222516(+) ACAAAA/TCTTTA 1 -- ds50010--------
    rs1420751261,2
    --111222522(+) CTTTAC/TGAAAA 1 -- ds50010--------
    rs71242081,2
    H--111222552(+) TAACTC/TGGGAA 1 -- ds50014Minor allele frequency- T:0.00NS EA 418
    rs127931771,2
    F,H--111222614(+) AATAGA/CCCATT 1 -- ds50015Minor allele frequency- C:0.01NS EA NA 400
    rs105021431,2
    C,F,H--111222713(+) AAATGG/ATACGC 1 -- ds500129Minor allele frequency- A:0.19NS NA EA WA 2504
    rs1463262901,2
    --111222826(+) TGTAAA/GTGCAT 1 -- ds50010--------
    rs122722631,2
    H--111223086(+) GGATTC/TTACCA 1 -- ut314Minor allele frequency- T:0.00NS EA 418
    rs10427521,2
    C,F,O,A,H--111223111(-) GTCACT/CATTAA 1 -- ut31 ese331Minor allele frequency- C:0.30MN NA NS EA WA 3078
    rs1859291471,2
    --111223118(+) TGACGA/TTGGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for POU2AF1 (111222977 - 111326355 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for POU2AF1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv39618CNV Loss16902084
    nsv490CNV Loss18451855
    nsv832268CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing POU2AF1
    DNA2.0 Custom Variant and Variant Library Synthesis for POU2AF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601206    OMIM disorders: --

    UniProtKB/Swiss-Prot: OBF1_HUMAN, Q16633
  • Note=A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia.
    Translocation t(3;11)(q27;q23) with BCL6

  • 20/21 diseases for POU2AF1 (see all 21):    About MalaCards
    primary effusion lymphoma    mediastinitis    agammaglobulinemia    common variable immunodeficiency
    seminoma    kaposi's sarcoma    acute myeloid leukemia    multiple myeloma
    chronic lymphocytic leukemia    myeloma    b-cell lymphomas    t-cell leukemia
    systemic lupus erythematosus    multiple sclerosis    myeloid leukemia    sarcoma
    lupus erythematosus    hodgkin's lymphoma    leukemia    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for POU2AF1:
    Lymphoma

    POU2AF1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for POU2AF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 36 3 17562619 (1), 11280769 (1), 15796964 (1)
    lymphoma 21.6 3 16186795 (1), 19224997 (1)

    Genetic Association Database (GAD): POU2AF1
    Human Genome Epidemiology (HuGE) Navigator: POU2AF1 (7 documents)

    Export disorders for POU2AF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU2AF1 gene, integrated from 9 sources (see all 85):
    (articles sorted by number of sources associating them with POU2AF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. (PubMed id 7623806)1, 2, 9 Luo Y. and Roeder R.G. (1995)
    2. Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization. (PubMed id 8617501)1, 3, 9 Junker S....Tommerup N. (1996)
    3. Genetic heterogeneity in colorectal cancer associatio ns between African and European americans. (PubMed id 20659471)1, 4 Kupfer S.S....Ellis N.A. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer. (PubMed id 18753146)1, 4 Pittman A.M....Houlston R.S. (2008)
    6. Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans. (PubMed id 16934875)1, 4 The Games Collaborative Group ....Sawcer S. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1. (PubMed id 11483517)1, 2 Tiedt R.... Matthias P. (2001)
    9. Regulation of BOB.1/OBF.1 stability by SIAH. (PubMed id 11483518)1, 2 Boehm J.... Wirth T. (2001)
    10. Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface. (PubMed id 10541551)1, 2 Chasman D....Pabo C.O. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5450 HGNC: 9211 AceView: POU2AF1 Ensembl:ENSG00000110777 euGenes: HUgn5450
    ECgene: POU2AF1 H-InvDB: POU2AF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POU2AF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POU2AF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POU2AF1 gene:
    Search GeneIP for patents involving POU2AF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for POU2AF1   OriGene RNAi products in human, mouse, rat for POU2AF1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for POU2AF1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for POU2AF1  
     OriGene qSTAR qPCR primer pairs in human, mouse for POU2AF1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for POU2AF1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for POU2AF1   OriGene Custom Protein Services for POU2AF1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POU2AF1
     QIAGEN SeqTarget long-range PCR primers for resequencing POU2AF1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU2AF1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU2AF1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU2AF1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU2AF1
     GenScript Custom Purified and Recombinant Proteins Services for POU2AF1 GenScript cDNA clones with any tag delivered in your preferred vector for POU2AF1
     GenScript Custom Assay Services for POU2AF1 GenScript Custom Superior Antibodies Services for POU2AF1
     GenScript Custom overexpressing Cell Line Services for POU2AF1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in POU2AF1 promoter
     Search Chromatin IP Primers for POU2AF1
     RT2 qPCR Primer Assay in human, mouse, rat POU2AF1
     GNC Network for POU2AF1
     SABiosciences PCR Arrays including human, mouse, rat POU2AF1
     Search Tocris compounds for POU2AF1 (OBF1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for POU2AF1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     POU2AF1 antibodies
     POU2AF1 proteins
     POU2AF1 lysates
     Antibodies for POU2AF1
     See all of Abcam's Antibodies, Kits and Proteins for POU2AF1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for POU2AF1




     Proteins for POU2AF1
     Antibodies for POU2AF1
     ELISAs for POU2AF1
     CLIAs for POU2AF1
     Search LifeMap BioReagents cell lines for POU2AF1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2AF1
     SwitchGear 3'UTR luciferase reporter plasmids for POU2AF1
     SwitchGear Promoter luciferase reporter plasmids for POU2AF1
     ThermoFisher Antibody for POU2AF1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU2AF1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for POU2AF1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POU2AF1
    Customized:
     lentivirus for stable overexpression of POU2AF1
     lentivirus expression plasmids for stable overexpression of POU2AF1
     adenovirus for overexpression of POU2AF1
     LSBio Antibodies in human, mouse, rat for POU2AF1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      POU2AF1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4