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POU2AF1 Gene

protein-coding   GIFtS: 55
GCID: GC11M111222

POU Class 2 Associating Factor 1

(Previous names: POU domain class 2, associating factor 1)
  See POU2AF1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
POU Class 2 Associating Factor 11 2     POU Domain Class 2, Associating Factor 11
OBF12 3 5     BOB12
BOB-12 3     OBF-12
OCA-B2 3     OCAB2
B-Cell-Specific Coactivator OBF-12 3     POU Domain Class 2-Associating Factor 12
OCT-Binding Factor 12 3     POU Domain, Class 2, Associating Factor 12

External Ids:    HGNC: 92111   Entrez Gene: 54502   Ensembl: ENSG000001107777   OMIM: 6012065   UniProtKB: Q166333   
ORGUL members:         

Export aliases for POU2AF1 gene to outside databases

Previous GC identifers: GC11M113575 GC11M112735 GC11M111256 GC11M110760 GC11M110728 GC11M107147


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for POU2AF1 Gene:
POU2AF1 (POU class 2 associating factor 1) is a protein-coding gene. Diseases associated with POU2AF1 include primary biliary cirrhosis, and nodular lymphocyte predominant hodgkin lymphoma. GO annotations related to this gene include transcription coactivator activity and transcription cofactor activity.

UniProtKB/Swiss-Prot: OBF1_HUMAN, Q16633
Function: Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1
mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It
recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required
for the formation of germinal centers

Gene Wiki entry for POU2AF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the POU2AF1 gene promoter:
         TBP   AML1a   MyoD   HNF-3beta   POU3F2   C/EBPalpha   FOXL1   c-Ets-1   MEF-2A   CHOP-10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): POU2AF1 promoter sequence
   Search Chromatin IP Primers for POU2AF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU2AF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q23.1

POU2AF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU2AF1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M111222:  view genomic region     (about GC identifiers)

Start:
111,222,977 bp from pter      End:
111,326,355 bp from pter
Size:
103,379 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OBF1_HUMAN, Q16633 (See protein sequence)
Recommended Name: POU domain class 2-associating factor 1  
Size: 256 amino acids; 27436 Da
1 PDB 3D structure from and Proteopedia for POU2AF1:
1CQT (3D)    
Secondary accessions: B2R8Z9 Q14983

Explore the universe of human proteins at neXtProt for POU2AF1: NX_Q16633

Explore proteomics data for POU2AF1 at MOPED

Post-translational modifications: 

  • Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (Probable)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POU2AF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006226.2  
    ENSEMBL proteins: 
     ENSP00000376786   ENSP00000433527  

    POU2AF1 Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for POU2AF1
    Cloud-Clone Corp. Proteins for POU2AF1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR015389 PD-C2-AF1

    Graphical View of Domain Structure for InterPro Entry Q16633

    ProtoNet protein and cluster: Q16633

    UniProtKB/Swiss-Prot: OBF1_HUMAN, Q16633
    Similarity: Belongs to the POU2AF1 family


    Find genes that share domains with POU2AF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OBF1_HUMAN, Q16633
    Function: Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1
    mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It
    recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required
    for the formation of germinal centers

         Genatlas biochemistry entry for POU2AF1:
    POU domain class 2,associating factor 1,B-cell specific coactivator,specifically associating with OCT1 (OTF1) and
    OCT2,fused with LAZ3/BCL6 in a B-cell leukemia cell line (Karpas 231)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003712transcription cofactor activity TAS7859290
    GO:0003713transcription coactivator activity TAS7859290
    GO:0005515protein binding IPI11483518
         
    Find genes that share ontologies with POU2AF1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for POU2AF1:
     Increased G1 DNA content 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pou2af1):
     cellular  growth/size/body  hematopoietic system  immune system  mortality/aging 
     renal/urinary system 

    Find genes that share phenotypes with POU2AF1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for POU2AF1: Pou2af1tm1Pjln Pou2af1tm1Pmt Pou2af1tm1Rgr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POU2AF1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU2AF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU2AF1

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate POU2AF1 (see all 10):
    hsa-miR-3128 hsa-miR-4251 hsa-miR-4318 hsa-miR-545 hsa-miR-766 hsa-miR-3142 hsa-miR-1252 hsa-miR-3126-3p
    SwitchGear 3'UTR luciferase reporter plasmidPOU2AF1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat POU2AF1

    Gene Editing
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    Sino Biological Human cDNA Clone for POU2AF1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU2AF1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2AF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OBF1_HUMAN, Q16633: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with POU2AF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including POU2AF1: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Transcription Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for POU2AF1

    Selected Interacting proteins for POU2AF1 (Q166331, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIAH1Q8IUQ41, 3EBI-943588,EBI-747107 I2D: score=3 
    SYKP434053I2D: score=4 
    SUB1P539993I2D: score=3 
    POU2F1P148593I2D: score=2 
    POU2F2P090863I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS7859290
    GO:0006959humoral immune response TAS7859290

    Find genes that share ontologies with POU2AF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POU2AF1 (OBF1)

    1 Novoseek inferred chemical compound relationship for POU2AF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 2 10604987 (2)



    Find genes that share compounds with POU2AF1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POU2AF1 gene: 
    NM_006235.2  

    Unigene Cluster for POU2AF1:

    POU class 2 associating factor 1
    Hs.654525  [show with all ESTs]
    Unigene Representative Sequence: Z49194
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393067(uc001plg.4) ENST00000525584 ENST00000531398 ENST00000530793
    ENST00000525662 ENST00000526535 ENST00000525499 ENST00000515029(uc001plh.1)
    ENST00000530229 ENST00000525527 ENST00000529065 ENST00000525890
    miRNA
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    Block miRNA regulation of human, mouse, rat POU2AF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate POU2AF1 (see all 10):
    hsa-miR-3128 hsa-miR-4251 hsa-miR-4318 hsa-miR-545 hsa-miR-766 hsa-miR-3142 hsa-miR-1252 hsa-miR-3126-3p
    SwitchGear 3'UTR luciferase reporter plasmidPOU2AF1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat POU2AF1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POU2AF1
      QuantiTect SYBR Green Assays in human, mouse, rat POU2AF1
      QuantiFast Probe-based Assays in human, mouse, rat POU2AF1

    Additional mRNA sequence: 

    AK313573.1 BC032549.1 X83504.1 Z47550.1 Z49194.1 

    4 DOTS entries:

    DT.97858926  DT.208246  DT.99962992  DT.92427082 

    Selected AceView cDNA sequences (see all 64):

    AI888552 BF510638 AL560547 Z47550 BM795830 BQ423501 BX462387 AA928017 
    AA362508 CR599556 BX443224 X83504 AW663547 BM464708 AI890020 CF121528 
    AW291431 NM_006235 AW207472 AW405850 BM464990 BX479626 BX445716 BX342926 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    POU2AF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTTTCTG
    POU2AF1 Expression
    About this image


    POU2AF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
    POU2AF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POU2AF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654525

    UniProtKB/Swiss-Prot: OBF1_HUMAN, Q16633
    Tissue specificity: B-cell specific

        Pathway & Disease-focused RT2 Profiler PCR Arrays including POU2AF1: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Transcription Factors in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU2AF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for POU2AF1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou2af11 , 5 POU domain, class 2, associating factor 11, 5 86.33(n)1
    89.45(a)1
      9 (27.95 cM)5
    189851  NM_011136.21  NP_035266.11 
     512136905 
    chicken
    (Gallus gallus)
    Aves POU2AF11 POU class 2 associating factor 1 71.52(n)
    66.54(a)
      373994  NM_204175.2  NP_989506.1 
    lizard
    (Anolis carolinensis)
    Reptilia POU2AF16
    POU class 2 associating factor 1
    57(a)
    1 ↔ 1
    GL343521.1(323530-349032)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pou2af11 POU class 2 associating factor 1 60.37(n)
    54.33(a)
      100496996  XM_002932933.2  XP_002932979.2 


    ENSEMBL Gene Tree for POU2AF1 (if available)
    TreeFam Gene Tree for POU2AF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POU2AF1 (see all 678)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1387928681,2
    --111222482(+) AAGAAA/GTGAAA 1 -- ds50010--------
    rs1829962071,2
    --111222516(+) ACAAAA/TCTTTA 1 -- ds50010--------
    rs1420751261,2
    --111222522(+) CTTTAC/TGAAAA 1 -- ds50010--------
    rs71242081,2
    H--111222552(+) TAACTC/TGGGAA 1 -- ds50014Minor allele frequency- T:0.00NS EA 418
    rs127931771,2
    F,H--111222614(+) AATAGA/CCCATT 1 -- ds50015Minor allele frequency- C:0.01NS EA NA 400
    rs105021431,2
    C,F,H--111222713(+) AAATGG/ATACGC 1 -- ds500129Minor allele frequency- A:0.19NS NA EA WA 2504
    rs1463262901,2
    --111222826(+) TGTAAA/GTGCAT 1 -- ds50010--------
    rs122722631,2
    H--111223086(+) GGATTC/TTACCA 1 -- ut314Minor allele frequency- T:0.00NS EA 418
    rs10427521,2
    C,F,O,A,H--111223111(-) GTCACT/CATTAA 1 -- ut31 ese331Minor allele frequency- C:0.30MN NA NS EA WA 3078
    rs1859291471,2
    --111223118(+) TGACGA/TTGGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for POU2AF1 (111222977 - 111326355 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for POU2AF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv39618CNV Loss16902084
    nsv490CNV Loss18451855
    nsv832268CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POU2AF1
    DNA2.0 Custom Variant and Variant Library Synthesis for POU2AF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601206    OMIM disorders: --

    UniProtKB/Swiss-Prot: OBF1_HUMAN, Q16633
  • Note=A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia.
    Translocation t(3;11)(q27;q23) with BCL6

  • 3 diseases for POU2AF1:    
    About MalaCards
    primary biliary cirrhosis    nodular lymphocyte predominant hodgkin lymphoma    primary mediastinal large b-cell lymphoma

    1 disease from the University of Copenhagen DISEASES database for POU2AF1:
    Lymphoma

    Find genes that share disorders with POU2AF1           About GenesLikeMe

    2 Novoseek inferred disease relationships for POU2AF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 36 3 17562619 (1), 11280769 (1), 15796964 (1)
    lymphoma 21.6 3 16186795 (1), 19224997 (1)

    Genetic Association Database (GAD): POU2AF1
    Human Genome Epidemiology (HuGE) Navigator: POU2AF1 (7 documents)

    Export disorders for POU2AF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POU2AF1 gene, integrated from 10 sources (see all 86):
    (articles sorted by number of sources associating them with POU2AF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. (PubMed id 7623806)1, 2, 9 Luo Y. and Roeder R.G. (Mol. Cell. Biol. 1995)
    2. Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization. (PubMed id 8617501)1, 3, 9 Junker S....Tommerup N. (Genomics 1996)
    3. Genetic heterogeneity in colorectal cancer associations between African and European americans. (PubMed id 20659471)1, 4 Kupfer S.S....Ellis N.A. (Gastroenterology 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer. (PubMed id 18753146)1, 4 Pittman A.M....Houlston R.S. (Hum. Mol. Genet. 2008)
    6. Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans. (PubMed id 16934875)1, 4  ....Sawcer S. (J. Neuroimmunol. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1. (PubMed id 11483517)1, 2 Tiedt R.... Matthias P. (EMBO J. 2001)
    9. Regulation of BOB.1/OBF.1 stability by SIAH. (PubMed id 11483518)1, 2 Boehm J.... Wirth T. (EMBO J. 2001)
    10. Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface. (PubMed id 10541551)1, 2 Chasman D.... Pabo C.O. (Genes Dev. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5450 HGNC: 9211 AceView: POU2AF1 Ensembl:ENSG00000110777 euGenes: HUgn5450
    ECgene: POU2AF1 H-InvDB: POU2AF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POU2AF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POU2AF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POU2AF1 gene:
    Search GeneIP for patents involving POU2AF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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