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POU1F1 Gene

protein-coding   GIFtS: 58
GCID: GC03M087307

POU Class 1 Homeobox 1

(Previous names: POU domain class 1, transcription factor 1)
(Previous symbol: PIT1)
Pneumococci & Pneumococcal Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
POU Class 1 Homeobox 11 2     POU1F1a2
PIT11 2 3 5     Pit-12
Growth Hormone Factor 11 2 3     Pituitary-Specific Positive Transcription Factor 12
GHF-12 3     POU Domain, Class 1, Transcription Factor 12
CPHD12 5     GHF13
POU Domain Class 1, Transcription Factor 11     PIT-13

External Ids:    HGNC: 92101   Entrez Gene: 54492   Ensembl: ENSG000000648357   OMIM: 1731105   UniProtKB: P280693   

Export aliases for POU1F1 gene to outside databases

Previous GC identifers: GC03M087883 GC03M090090 GC03M087188 GC03M087229 GC03M087391


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POU1F1 Gene:
This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The
protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations
in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for POU1F1 Gene:
POU1F1 (POU class 1 homeobox 1) is a protein-coding gene. Diseases associated with POU1F1 include pituitary hormone deficiency, combined 1, and hypothyroidism due to deficient transcription factors involved in pituitary development or function. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PIT1_HUMAN, P28069
Function: Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope
phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds
to the consensus sequence 5'-TAAAT-3'

Gene Wiki entry for POU1F1 (Pituitary-specific positive transcription factor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the POU1F1 gene promoter:
         Pax-5   p53   AP-1   ATF-2   CREB   deltaCREB   c-Jun   Ik-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOU1F1 promoter sequence
   Search Chromatin IP Primers for POU1F1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU1F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p11   Ensembl cytogenetic band:  3p11.2   HGNC cytogenetic band: 3p11.2

POU1F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU1F1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M087307:  view genomic region     (about GC identifiers)

Start:
87,308,554 bp from pter      End:
87,325,737 bp from pter
Size:
17,184 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PIT1_HUMAN, P28069 (See protein sequence)
Recommended Name: Pituitary-specific positive transcription factor 1  
Size: 291 amino acids; 32912 Da
Sequence caution: Sequence=CAA54440.2; Type=Erroneous gene model prediction;
Secondary accessions: O75757 Q15132 Q15133 Q9UD34 Q9UEL3
Alternative splicing: 2 isoforms:  P28069-1   P28069-2   (Altered in its ability to trans-activate compared to isoform B)

Explore the universe of human proteins at neXtProt for POU1F1: NX_P28069

Explore proteomics data for POU1F1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POU1F1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000297.1  NP_001116229.1  

    ENSEMBL proteins: 
     ENSP00000263781   ENSP00000342931   ENSP00000454072   ENSP00000452610  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POU: Homeoboxes / POU class

    Selected InterPro protein domains (see all 7):
     IPR015586 Pit_1
     IPR010982 Lambda_DNA-bd_dom
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS

    Graphical View of Domain Structure for InterPro Entry P28069

    ProtoNet protein and cluster: P28069

    2 Blocks protein domains:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PIT1_HUMAN, P28069
    Similarity: Belongs to the POU transcription factor family. Class-1 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    POU1F1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIT1_HUMAN, P28069
    Function: Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope
    phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds
    to the consensus sequence 5'-TAAAT-3'

         Genatlas biochemistry entry for POU1F1:
    POU domain,class 1,transcription factor 1,mammalian homeo box backfoot,Drosophila bicoid related,expressed in
    Rathke pouch,at an early stage of pituitary development and in a subset of adult anterior pituitary cells that
    express POMC,binding PITX2,reciprocally interacting with GATA2 for the mediation of signaling gradient-induced
    determination of pituitary cell types

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0001102RNA polymerase II activating transcription factor binding IPI12612071
    GO:0001105RNA polymerase II transcription coactivator activity IDA9685346
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
         
    POU1F1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for POU1F1:
     Decreased p24 protein expressi 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pou1f1):
     craniofacial  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system  reproductive system 

    POU1F1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POU1F1
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    1 qRT-PCR Assays for microRNA that regulate POU1F1:
    hsa-miR-4251
    SwitchGear 3'UTR luciferase reporter plasmidPOU1F1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat POU1F1

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    GenScript: all cDNA clones in your preferred vector (see all 2): POU1F1 (NM_001122757)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIT1_HUMAN, P28069: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    POU1F1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POU1F1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glucocorticoid receptor regulatory network
    Glucocorticoid receptor regulatory network


    1 BioSystems Pathway for POU1F1
        Glucocorticoid receptor regulatory network


        Pathway & Disease-focused RT2 Profiler PCR Arrays including POU1F1: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Neurotoxicity in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for POU1F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for POU1F1 (P280692, 3 ENSP000003429314) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ETS1P149212, 3, ENSP000003764364MINT-14055 I2D: score=1 STRING: ENSP00000376436
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    NR3C1P041503, ENSP000002315094I2D: score=2 STRING: ENSP00000231509
    MED1Q156483, ENSP000003006514I2D: score=1 STRING: ENSP00000300651
    NR1I3Q149943, ENSP000003569594I2D: score=1 STRING: ENSP00000356959
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001708cell fate specification IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS1487156
    GO:0008284positive regulation of cell proliferation IEA--

    POU1F1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POU1F1 (PIT1)

    Selected Novoseek inferred chemical compound relationships for POU1F1 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ptx1 83.5 8 9514159 (2), 10859489 (2), 18079591 (1), 11027489 (1) (see all 5)
    acth 59.9 17 8890999 (3), 8739890 (3), 8949563 (2), 12780757 (1) (see all 10)
    forskolin 43 18 8625901 (4), 7961740 (3), 16879162 (1), 1584227 (1) (see all 5)
    bromocriptine 42.6 2 7621575 (1), 9207961 (1)
    ribonucleic acid 40.1 7 7608249 (2), 8869065 (2), 8733768 (1), 8784102 (1) (see all 5)
    cyclic amp 33.7 21 8645191 (4), 8625901 (2), 9751061 (2), 8524234 (2) (see all 7)
    estrogen 20.9 18 15221415 (3), 2379827 (2), 8733768 (1), 8424109 (1) (see all 12)
    dopamine 13.1 9 7706253 (3), 1835974 (3), 9167960 (1), 10449917 (1)
    okadaic acid 12.8 6 9717847 (3), 8232316 (1), 11266513 (1)
    arginine 12 4 9588494 (1), 12773133 (1), 9829213 (1)



    POU1F1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for POU1F1 gene (2 alternative transcripts): 
    NM_000306.3  NM_001122757.2  

    Unigene Cluster for POU1F1:

    POU class 1 homeobox 1
    Hs.591654  [show with all ESTs]
    Unigene Representative Sequence: NM_001122757
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000350375(uc010hoj.1 uc003dqq.1) ENST00000344265 ENST00000561167
    ENST00000560656

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    1 qRT-PCR Assays for microRNA that regulate POU1F1:
    hsa-miR-4251
    SwitchGear 3'UTR luciferase reporter plasmidPOU1F1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat POU1F1

    Additional mRNA sequence: 

    D10216.1 L18781.1 X62429.1 X72215.1 

    2 DOTS entries:

    DT.206672  DT.91910385 

    8 AceView cDNA sequences:

    NM_000306 D10216 L18781 X72215 CD242816 CD237360 X62429 AV747622 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    POU1F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAACTGAAA
    POU1F1 Expression
    About this image

    POU1F1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POU1F1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591654
        Pathway & Disease-focused RT2 Profiler PCR Arrays including POU1F1: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Neurotoxicity in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU1F1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for POU1F1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou1f11 , 5 POU domain, class 1, transcription factor 11, 5 87.74(n)1
    95.53(a)1
      16 (37.25 cM)5
    187361  NM_008849.41  NP_032875.11 
     655205125 
    chicken
    (Gallus gallus)
    Aves POU1F11 POU class 1 homeobox 1 78.4(n)
    86.67(a)
      374215  NM_204319.1  NP_989650.1 
    lizard
    (Anolis carolinensis)
    Reptilia POU1F16
    POU class 1 homeobox 1
    71(a)
    1 ↔ 1
    3(161399902-161417222)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pou1f11 POU class 1 homeobox 1 74.87(n)
    78.86(a)
      100492413  XM_002931760.2  XP_002931806.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pou1f11 POU domain, class 1, transcription factor 1 66.45(n)
    71.85(a)
      405777  NM_212851.1  NP_998016.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-66
    Protein CEH-6 (ceh-6) mRNA, complete cds
    29(a)
    1 ↔ 1
    I(8498114-8502412) WBGene00000431


    ENSEMBL Gene Tree for POU1F1 (if available)
    TreeFam Gene Tree for POU1F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POU1F1 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F12  POU3F42  POU3F32  POU4F32  
    POU3F22  POU2F22  POU5F1B2  POU4F12  POU2F12  POU6F12  POU5F12  
    Selected SIMAP similar genes for POU1F1 using alignment to 3 protein entries:     PIT1_HUMAN (see all proteins) (see all similar genes):
    OCT6    POU6F1    POU5F1P4    POU3F1    POU3F4    POU4F1
    OCT-2    POU3F3    POU5F1    POU2F1    POU2F2    POU5F1P1
    POU3F2    POU2F3    POU5F1B    POU4F2    POU4F3    NKX2-5

    POU1F1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POU1F1 (see all 468)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0037784
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0037782 R Q mis40--------
    VAR_0634254
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0634252 R Q mis40--------
    VAR_0105744
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0105742 F C mis40--------
    VAR_0152604
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0152602 W R mis40--------
    VAR_0037774
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0037772 P L mis40--------
    VAR_0105764
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0105762 P S mis40--------
    VAR_0037814
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0037812 R W mis40--------
    VAR_0634274
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0634272 E K mis40--------
    VAR_0105754
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0105752 E G mis40--------
    VAR_0037794
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0037792 A P mis40--------
    VAR_0634264
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0634262 S R mis40--------
    rs358936261,2
    C,Fnon-pathogenic187274007(-) GAAACA/TCAGCA 3 T S int1 mis16Minor allele frequency- T:0.01MN CSA 410
    rs1048937551,2
    Cpathogenic187260549(-) AAAAAC/TGGGTG 4 R W mis10--------
    rs1048937601,2
    Cpathogenic187260612(-) CTGAAG/TAACTG 4 E * stg10--------
    rs1048937621,2
    Cpathogenic187260645(-) ATAAAC/TCTTCT 4 P S mis10--------
    rs1048937641,2
    Cpathogenic187260672(-) CTCTGA/GAGAGA 4 K E mis10--------
    rs1048937581,2
    Cpathogenic187262688(-) CCAAAC/TGGCTG 4 R W mis10--------
    rs1048937661,2
    Cpathogenic187262728(-) CTCAGC/GTTTAA 4 S R mis10--------
    rs1048937651,2
    Cpathogenic187262750(-) CTGCCA/GATTTG 4 Q R mis10--------
    rs1048937541,2
    Cpathogenic187262751(-) TCTGCC/TGATTT 4 R * stg10--------
    rs1048937561,2
    Cpathogenic187262793(-) CCCTGC/GCAGCT 4 P A mis10--------
    rs1048937631,2
    Cpathogenic187264884(-) GAATTA/TAATTA 4 K * stg10--------
    rs1048937591,2
    Cpathogenic187264889(-) GAGACA/GAATTA 4 Q R mis10--------
    rs1048937611,2
    Cpathogenic187264913(-) AAAGTG/TTGCCA 4 C F mis10--------
    rs1048937571,2
    Cpathogenic187276977(-) TCTGCC/TTCTGA 4 P L mis10--------
    rs1823891861,2
    C--87259737(+) CCCTGA/GAGAGG 2 -- ds50010--------
    rs38046051,2
    C,F,H--87259993(+) TAAAAC/GTATAA 2 -- ds500115Minor allele frequency- G:0.27MN NS EA NA WA CSA 1019
    rs343392061,2
    F--87259997(-) GTGTC-/TTATAST 2 -- ds50015Minor allele frequency- TT:0.01MN 408
    rs38401961,2
    C--87260009(+) CTCCA-/GCTCTN 2 -- ds50015Minor allele frequency- G:0.00MN 376
    rs354458741,2
    C,F--87260150(-) ATGTAT/CATTAG 2 -- ds50016Minor allele frequency- C:0.05MN NA 496
    rs1445641871,2
    --87260175(+) CTTATA/TAACCC 2 -- ds50010--------
    rs67925001,2
    C--87260271(+) ATAGAT/CAATGT 2 -- ut3117Minor allele frequency- C:0.00MN NA WA CSA EA 755
    rs1869694261,2
    --87260300(+) TTTTAA/TGTAAA 2 -- ut310--------
    rs2013149811,2
    --87260343(+) TTTTT-/ATAAAA 2 -- ut310--------
    rs339361081,2
    C,F--87260344(-) TTTTTT/AAAAAA 2 -- ut3124Minor allele frequency- A:0.48MN NA WA 1870
    rs1902879931,2
    --87260346(+) TTTTAA/TAAAAA 2 -- ut310--------
    rs3765403221,2
    C,F--87260352(+) AAAAA-/AGTGGA 2 -- ut315Minor allele frequency- A:0.01MN 396
    rs1440798291,2
    F--87260493(+) CTGCAC/TTCAAG 4 E syn11Minor allele frequency- T:0.00NA 4144
    rs762966261,2
    C--87260699(+) GCTGGC/TGGGGG 2 -- int12Minor allele frequency- T:0.01EA EU 949
    rs2019951031,2
    --87260700(+) CTGGCA/GGGGGG 2 -- int10--------
    rs1821270671,2
    C--87260702(+) GGCGGC/G/TGGGTG 2 -- int10--------
    rs2005291991,2
    --87260705(+) GGGGGA/GTGGAC 2 -- int10--------
    rs1867641041,2
    --87261118(+) TTGCTA/GAGCAT 2 -- int10--------
    rs1930282191,2
    --87261248(+) AGACAC/TCATGG 2 -- int10--------
    rs1995550321,2
    --87261456(+) TATTA-/TTTT  
            
    TTTTT
    2 -- int10--------
    rs1508086401,2
    C--87261459(+) TATTT-/TTT   
       TTTTA
    TTTAT
    2 -- int10--------
    rs124972621,2
    C,H--87261462(+) TTTTTA/TTTTAT 2 -- int1 trp31Minor allele frequency- T:0.00WA 2
    rs671403671,2
    C--87261462(+) TTTTT-/ATTT/TTTT
    ATTTATTTATTT
    ATTTA
    2 -- int12NA 4
    rs1857706601,2
    --87261593(+) CCTCCC/TAGGTT 2 -- int10--------
    rs2014068911,2
    C--87261928(+) GCTATA/CATGTG 2 -- int11Minor allele frequency- C:0.00EU 1135
    rs1396493671,2
    --87261996(+) GGATTG/TCAAAT 2 -- int10--------
    rs1881834121,2
    --87262099(+) TCAACA/GCAGAA 2 -- int10--------
    rs1931655671,2
    --87262352(+) AATTTC/TTCTAG 2 -- int10--------
    rs361059651,2
    C,F--87262528(-) AATAAA/GCATTT 2 -- int15Minor allele frequency- G:0.01MN 404
    rs344536551,2
    F--87262555(-) TTTCCG/ACCTTT 2 -- int15Minor allele frequency- A:0.01MN 404
    rs1846959441,2
    --87262603(+) CTTATC/TGAAGC 2 -- int10--------
    rs2000891821,2
    C--87262621(+) TTTAGG/TTTAAA 2 -- int10--------
    rs2009284071,2
    C--87262777(+) ATTCAG/TAGCCA 4 Y S mis10--------
    rs356777311,2
    C,F--87262782(-) GTGCAT/CGGCTC 4 /H syn12Minor allele frequency- C:0.00NA 4622
    rs2018552501,2
    --87262865(+) TTTCCA/GGGAAA 2 -- int10--------
    rs1886672891,2
    --87262935(+) TTTTTG/TAACTA 2 -- int10--------
    rs1479099271,2
    --87262939(+) TTAACC/TATATA 2 -- int10--------
    rs725631341,2
    F--87263168(-) TGRTAA/CCTAAC 2 -- int15Minor allele frequency- C:0.01MN 400
    rs111279751,2
    C,F,A,H--87263171(+) AGTTAT/CCAAAT 2 -- int115Minor allele frequency- C:0.37NA MN WA CSA EA 774
    rs725631351,2
    F--87263193(-) TAAAAT/ATTTTT 2 -- int15Minor allele frequency- A:0.01MN 400
    rs725631361,2
    C,F--87263227(-) TAACCG/ATATAT 2 -- int17Minor allele frequency- A:0.02MN WA 520
    rs725631371,2
    C,F--87263243(-) AGAATG/TTTATG 2 -- int17Minor allele frequency- T:0.04MN WA NA 638
    rs725631381,2
    F--87263293(-) TTTATT/CTAGTA 2 -- int15Minor allele frequency- C:0.01MN 404
    rs124861591,2
    C,F,A,H--87263333(+) CATATT/ATATTA 2 -- int117Minor allele frequency- A:0.23NA NS EA MN 1382
    rs1399275131,2
    --87263378(+) GAGCCA/CATTTT 2 -- int10--------
    rs725631391,2
    C,F--87263496(-) TCTATC/TTATAT 2 -- int17Minor allele frequency- T:0.02MN WA EA 642
    rs1428070721,2
    --87263526(+) CAAAGA/CTTCCT 2 -- int10--------
    rs801651311,2
    C,F--87263590(+) ATATAC/TCTATA 2 -- int11Minor allele frequency- T:0.06EA 120
    rs1440724141,2
    C--87263739(+) GTCAA-/TTG   
      TTATAG
    TTGTT
    2 -- int10--------
    rs1813675571,2
    --87263772(+) CTTCAA/GTAGAA 2 -- int10--------
    rs3735256011,2
    C--87263820(+) GGAAAC/G/TTAAAT 2 -- int10--------
    rs1837354731,2
    --87263869(+) TAATAA/GAAGAA 2 -- int10--------
    rs1895281081,2
    --87264040(+) AGAAAC/TAGATT 2 -- int10--------
    rs746875621,2
    F--87264063(+) GCCGTT/CTTGGA 2 -- int11Minor allele frequency- C:0.01EA 120
    rs1819941121,2
    --87264152(+) TGATAA/TCATCT 2 -- int10--------
    rs792941581,2
    C--87264218(+) TGCTGC/TGCATA 2 -- int10--------
    rs1510344191,2
    --87264361(+) TGGAAC/TTTGAC 2 -- int10--------
    rs1411235551,2
    --87264376(+) CCACAA/GAGGAA 2 -- int10--------
    rs1874138641,2
    --87264492(+) TGGAAA/GGATAC 2 -- int10--------
    rs1502651871,2
    --87264515(+) CAACGA/TTATAC 2 -- int10--------
    rs98371951,2
    C,F,H--87264587(+) AATGTA/GTGGCC 2 -- int123Minor allele frequency- G:0.41NS EA NA WA CSA 2343
    rs1158641241,2
    F--87264673(+) ATTATT/CAATTT 2 -- int11Minor allele frequency- C:0.03WA 118
    rs622578011,2
    C,F--87264687(+) AATTAT/GGTATT 2 -- int12Minor allele frequency- G:0.02NA 122
    rs1905416131,2
    --87264748(+) AACGAC/GTAACT 2 -- int10--------
    rs49884621,2
    C,F--87264793(-) AAAAAG/ATACAA 2 -- int112Minor allele frequency- A:0.27NA MN EA 776
    rs49884611,2
    C,F--87264815(-) GTTAAA/GTCTCT 2 -- int15Minor allele frequency- G:0.00MN 408
    rs1997466971,2
    C--87264874(+) AGCACA/GTACCT 2 -- int11Minor allele frequency- G:0.00EU 1301
    rs1859653571,2
    C--87264875(+) GCACAC/TACCTA 2 -- int10--------
    rs1420463081,2
    C--87264890(+) AATTCG/TTCTCA 4 R syn11Minor allele frequency- T:0.00NA 4474
    rs1433730071,2
    C,F--87264947(+) ATCCAT/CGTCTA 4 /M /V mis12Minor allele frequency- C:0.00NA EU 5865
    rs1383561381,2
    C,F--87264980(+) TTTCCG/ACCTGA 4 /R /W mis12Minor allele frequency- A:0.00NA EU 5865
    rs49884601,2
    C,F,H--87265065(-) GACCAC/TACCTT 4 H syn1 ese314Minor allele frequency- T:0.00MN NS EA NA EU 6959
    rs2010652851,2
    C--87265093(+) AAGGGG/TTTAAA 4 N T mis10--------
    rs22706671,2
    C--87265207(+) CTAGCC/GTGTCT 2 -- int16Minor allele frequency- G:0.00EA MN 1870
    rs1181194401,2
    C,F--87265343(+) AGAAGC/TAGGGG 2 -- int11Minor allele frequency- T:0.11EA 120
    rs1900329681,2
    --87265738(+) CTTGAA/GGAGTG 2 -- int10--------
    rs1825818151,2
    --87265766(+) GGTAAC/TCTTAA 2 -- int10--------
    rs1858396971,2
    --87265925(+) AAAGCA/GTTGAC 2 -- int10--------
    rs1406725141,2
    C--87266026(+) AGTCTA/TTCTCA 2 -- int10--------
    rs1910375511,2
    --87266123(+) TTTATC/TGACAA 2 -- int10--------
    rs1836683031,2
    --87266136(+) ATTCTA/GCTTCA 2 -- int10--------
    rs1457665081,2
    --87266146(+) AATTTA/GTATTA 2 -- int10--------
    rs1379364231,2
    --87266293(+) ATACAA/GTATAA 2 -- int10--------
    rs74331161,2
    C,F,A,H--87266424(+) GCATCC/GAAAGA 2 -- int112Minor allele frequency- G:0.27NA WA CSA EA 377
    rs1890217021,2
    --87266563(+) ATTACA/TATGGA 2 -- int10--------
    rs4949851,2
    H--87266759(+) AATTGT/GTGGtt 2 -- int14Minor allele frequency- G:0.00NS EA 418
    rs98238931,2
    C,F,A--87266829(+) tatttT/Atataa 2 -- int11Minor allele frequency- A:0.00NA 2
    rs1926924611,2
    --87266843(+) TTATAG/TTTTAT 2 -- int10--------
    rs1829582251,2
    --87266996(+) AAATAC/TGTAAT 2 -- int10--------
    rs731504741,2
    --87267204(+) CTATCC/TATTTT 2 -- int10--------
    rs98245921,2
    C,F,H--87267240(+) CAGACA/CAGAGA 2 -- int112Minor allele frequency- C:0.40NS EA NA WA CSA 784
    rs1876291341,2
    C--87267440(+) TGAAGA/GCTTGT 2 -- int10--------
    rs1430476641,2
    --87267599(+) ATTTTC/GTACAT 2 -- int10--------
    rs1916724791,2
    --87267677(+) AAAATC/TTGTGT 2 -- int10--------
    rs1842648081,2
    --87267788(+) TTCTAC/TGCAAC 2 -- int10--------
    rs1889953361,2
    --87267828(+) TATCAA/TCTTTA 2 -- int10--------
    rs1166821141,2
    F--87267915(+) GAAAGT/CAAATA 2 -- int11Minor allele frequency- C:0.01WA 118
    rs1166380501,2
    C,F--87267932(+) CTCCAG/ATGCCC 2 -- int11Minor allele frequency- A:0.02NA 120
    rs1481923091,2
    --87268015(+) TGCCCA/GGTTCA 2 -- int10--------
    rs1927377811,2
    --87268048(+) GGCAAA/TTTAAA 2 -- int10--------
    rs1413806681,2
    --87268341(+) TGCACC/TGCCAT 2 -- int10--------
    rs1508027281,2
    --87268342(+) GCACCA/GCCATG 2 -- int10--------
    rs76373881,2
    C,F,A,H--87268352(+) gctcaT/Actact 2 -- int114Minor allele frequency- A:0.34NS EA NA WA CSA 790
    rs1845288061,2
    --87268538(+) GAAAGA/TGGACA 2 -- int10--------
    rs4011051,2
    H--87268625(-) TTTTCC/TTTCTT 2 -- int1 trp34Minor allele frequency- T:0.00NS EA 412
    rs2012670841,2
    C--87268666(+) CCTTT-/CCCCTT 2 -- int10--------
    rs577703551,2
    C--87268670(+) TTCCCC/TTTTTT 2 -- int10--------
    rs1397400961,2
    C--87268802(+) GGGACG/TACAGG 2 -- int10--------
    rs74314131,2
    C,H--87268808(+) acaggC/Tgcctg 2 -- int18Minor allele frequency- T:0.00NA WA CSA 19
    rs117188391,2
    C,F,H--87268822(+) ccacaC/Tccggc 2 -- int11Minor allele frequency- T:0.33NA 6
    rs1500092371,2
    C--87269021(+) AGTATA/CTACAA 2 -- int10--------
    rs4533731,2
    F--87269117(+) TGTTTC/TTAGCA 2 -- int11Minor allele frequency- T:0.03MN 184
    rs762483581,2
    C,F--87269141(+) TTGGGG/AGAGTG 2 -- int11Minor allele frequency- A:0.04WA 118
    rs1905382901,2
    --87269156(+) GAGTGA/GTTGGG 2 -- int10--------
    rs1452093831,2
    --87269180(+) CAATAC/TGTTTT 2 -- int10--------
    rs4296251,2
    H--87269279(-) TTTCAG/AAAAAT 2 -- int15Minor allele frequency- A:0.00MN NS EA 602
    rs3949391,2
    H--87269340(-) CACTTC/TTGAGC 2 -- int15Minor allele frequency- T:0.00MN NS EA 602
    rs21298751,2
    C,F,H--87269349(+) TGTTTG/TCACAC 2 -- int17Minor allele frequency- T:0.08NS EA WA 540
    rs1819821771,2
    --87269583(+) TCTCAC/TGTTAC 2 -- int10--------
    rs1470779521,2
    C--87269602(+) GCCTT-/AAAAAA 2 -- int10--------
    rs791209801,2
    C,F--87269668(+) AACATG/ACACAG 2 -- int12Minor allele frequency- A:0.03WA NA 238
    rs1487129021,2
    --87269672(+) TGCACA/GGGAAC 2 -- int10--------
    rs1857300941,2
    --87269699(+) CCATAC/TATTCC 2 -- int10--------
    rs729240421,2
    C,F--87269722(+) AGGCAT/CAAAAA 2 -- int12Minor allele frequency- C:0.04WA 120
    rs1157353441,2
    C,F--87269734(+) TCAAAG/AGAAAT 2 -- int11Minor allele frequency- A:0.03NA 120
    rs1422545141,2
    --87269799(+) GTACAA/GCTGGG 2 -- int10--------
    rs769583981,2
    C,F--87269817(+) GCCTGT/CGTTTG 2 -- int12Minor allele frequency- C:0.03WA NA 238
    rs1468846761,2
    --87269959(+) GAAAAC/GGGTTG 2 -- int10--------
    rs798479441,2
    C,F--87269970(+) CCAACC/TCCTAG 2 -- int12Minor allele frequency- T:0.05WA NA 238
    rs1406907821,2
    --87270068(+) TAGAGC/TTGTTA 2 -- int10--------
    rs1890218831,2
    --87270094(+) AGGGCC/TAAATA 2 -- int10--------
    rs725491421,2
    F--87270159(-) TTTTCA/GTTTTT 2 -- int15Minor allele frequency- G:0.01MN 408
    rs725491431,2
    F--87270165(-) CCCATC/TTTTTC 2 -- int15Minor allele frequency- T:0.01MN 408
    rs353186471,2
    C,F--87270175(-) ATTTT-/TGGAAC 2 -- int15Minor allele frequency- T:0.01MN 404
    rs345074921,2
    F--87270189(-) ARATAG/TTCTAG 2 -- int15Minor allele frequency- T:0.01MN 400
    rs98229111,2
    C,F,A,H--87270193(+) ACTATC/TTCTCC 2 -- int131Minor allele frequency- N:0.00EA NA MN NS WA CSA 2964
    rs354223841,2
    C,F--87270215(-) AAATCA/GGCCTG 2 -- int16Minor allele frequency- G:0.03MN EA 520
    rs725491441,2
    C,F--87270222(-) AAAACG/AGAAAT 2 -- int17Minor allele frequency- A:0.03MN WA NA 646
    rs725491451,2
    F--87270306(-) YAATTC/TTTTTT 2 -- int15Minor allele frequency- T:0.01MN 404
    rs343933461,2
    C,F--87270311(-) GCATCC/TAATTC 2 -- int17Minor allele frequency- T:0.02MN WA 520
    rs725491461,2
    F--87270317(-) TGATGA/GGCATC 2 -- int15Minor allele frequency- G:0.01MN 400
    rs1501218371,2
    C--87270363(+) GTTTG-/TTTGT 
            
    TTTGT
    2 -- int10--------
    rs1157030701,2
    F--87270464(+) TGGTGG/TGTTTA 2 -- int11Minor allele frequency- T:0.01WA 118
    rs1140612811,2
    C,F--87270529(+) AACCCC/TCATTG 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1810367191,2
    --87270613(+) GTTTTA/GAGAAC 2 -- int10--------
    rs750377501,2
    C--87270777(+) AGAGTA/GCGTGA 2 -- int12Minor allele frequency- G:0.06CSA WA 120
    rs772812451,2
    C,F--87270778(+) GAGTAC/TGTGAA 2 -- int11Minor allele frequency- T:0.03WA 118
    rs3862001,2
    H--87270800(-) TGATTT/GCTCTT 2 -- int1 trp35Minor allele frequency- G:0.00MN NS EA 602
    rs1466037591,2
    --87270917(+) CAATGC/TTAGTA 2 -- int10--------
    rs1409512541,2
    --87271323(+) ATAAGA/GTTTCT 2 -- int10--------
    rs1865913421,2
    --87271504(+) ATATAA/GACATT 2 -- int10--------
    rs1913521451,2
    --87271546(+) AATTTA/TTGAGA 2 -- int10--------
    rs788531541,2
    C,F--87271561(+) TTTAAC/GAATCC 2 -- int12Minor allele frequency- G:0.05WA NA 238
    rs1828441751,2
    --87271684(+) TTCTGC/TTCTTG 2 -- int10--------
    rs45492751,2
    H--87271816(+) TGTATC/GAGAAA 2 -- int14Minor allele frequency- G:0.00NS EA 416
    rs1501106301,2
    --87271836(+) TGCCAA/GCACTC 2 -- int10--------
    rs3656441,2
    F--87271900(-) CCTCAG/AAATTC 2 -- int11Minor allele frequency- A:0.38MN 184
    rs1384256751,2
    --87271958(+) GGGTGG/TGAGTT 2 -- int10--------
    rs1488304911,2
    --87272056(+) CAACTA/GGCAGG 2 -- int10--------
    rs1434226481,2
    --87272078(+) TGCTGA/GGTTAA 2 -- int10--------
    rs1164512961,2
    F--87272163(+) AGTGGC/GATGTG 2 -- int11Minor allele frequency- G:0.02WA 118
    rs171894661,2
    C,F,H--87272457(+) AAATGT/CTAGGA 2 -- int138Minor allele frequency- C:0.15NA NS EA MN WA CSA 3714
    rs1860698191,2
    --87272489(+) GCTTGA/CTAGAA 2 -- int10--------
    rs1909741521,2
    --87272502(+) TAGGAC/GAAGCT 2 -- int10--------
    rs1382100141,2
    --87272616(+) TATTTC/GCTCCA 2 -- int10--------
    rs681673701,2
    C,F--87272631(-) AATTTT/GCAAGT 2 -- int18Minor allele frequency- G:0.04MN WA 514
    rs1437221131,2
    --87272663(+) TCTGCA/GGTTTT 2 -- int10--------
    rs1834554701,2
    --87272794(+) TGCACA/TCGCAC 2 -- int10--------
    rs1472051661,2
    --87272859(+) TAATAA/CAGATA 2 -- int10--------
    rs1874301871,2
    --87272921(+) TTTAGA/GGTACA 2 -- int10--------
    rs124869321,2
    C,A,H--87272965(+) ACATGC/TGCCAT 2 -- int12Minor allele frequency- T:0.27NA 122
    rs1161214611,2
    F--87272966(+) CATGCG/ACCATG 2 -- int11Minor allele frequency- A:0.01NA 120
    rs26462251,2
    C,F,A,H--87272995(+) TAACTT/CGTCAT 2 -- int18Minor allele frequency- C:0.43NA WA CSA EA 251
    rs1921770241,2
    C--87273006(+) TTAGCA/GTTAGG 2 -- int10--------
    rs1388067981,2
    --87273055(+) TGAAAA/GTCCTG 2 -- int10--------
    rs1149524211,2
    C,F--87273061(+) TCCTGC/TGCATA 2 -- int11Minor allele frequency- T:0.01WA 118
    rs1419093051,2
    --87273078(+) CTGTGC/TACTTT 2 -- int10--------
    rs1828146561,2
    --87273149(+) ATAGAC/TCTCAT 2 -- int10--------
    rs1506448251,2
    C--87273169(+) CTACGC/TATTCC 2 -- int10--------
    rs170241181,2
    C,F,H--87273192(+) CTTCAA/GTGCCT 2 -- int127Minor allele frequency- G:0.34NA NS EA CSA WA 2906
    rs1143328901,2
    F--87273336(+) CTAAAG/TCCTGA 2 -- int11Minor allele frequency- T:0.03WA 118
    rs350537561,2
    C,F--87273438(+) TGATG-/A/AGG 
     GT
    /GGGG
    GGGGG
    2 -- int12NA 4
    rs2000346131,2
    C--87273438(+) TGATGA/GGGGGG 2 -- int10--------
    rs350154981,2
    F--87273442(+) TGGGGT/GGGGTG 2 -- int11Minor allele frequency- G:0.00NA 2
    rs745688241,2
    F--87273445(+) GGGGGG/CTGTTC 2 -- int11Minor allele frequency- C:0.03WA 118
    rs1927564541,2
    --87273640(+) CAATAA/GCATCA 2 -- int10--------
    rs1397472341,2
    --87273706(+) ACTCAA/GGAAGC 2 -- int10--------
    rs1181564521,2
    F--87273758(+) CCCCTA/GTGGTC 2 -- int11Minor allele frequency- G:0.02EA 120
    rs1843959841,2
    --87273806(+) ATTTTG/TAACAG 2 -- int10--------
    rs341343261,2
    C,F--87273872(-) TTCTGG/AGCCTG 2 -- int16Minor allele frequency- A:0.01MN WA 526
    rs1892214341,2
    C--87274026(+) GTCACC/GGAGAA 3 S int1 syn10--------
    rs1462898051,2
    --87274101(+) TATAAC/GGATTC 2 -- int10--------
    rs1149783801,2
    F--87274103(+) TAAGGA/TTTCAA 2 -- int11Minor allele frequency- T:0.02WA 118
    rs1923842521,2
    --87274160(+) AGTTAC/TATGCC 2 -- int10--------
    rs1397799131,2
    --87274244(+) TGTAAC/TGAGAT 2 -- int10--------
    rs38283651,2
    C,F,H--87274252(+) GATAAT/CAAATC 2 -- int16Minor allele frequency- C:0.01EA NS NA 2032
    rs1847212331,2
    C--87274307(+) TACGAC/GTGCCC 2 -- int10--------
    rs1445012501,2
    --87274455(+) TAAAGC/TAGTCT 2 -- int10--------
    rs3009771,2
    C,F,A,H--87274495(+) AACAGC/TGTATT 2 -- int125Minor allele frequency- T:0.40MN NA EA NS WA CSA 1737
    rs725631411,2
    C,F--87274496(-) AAATAC/TRCTGT 2 -- int17Minor allele frequency- T:0.02MN WA NA 638
    rs1466145541,2
    --87274625(+) CAATAC/TATGAT 2 -- int10--------
    rs725492231,2
    C,F--87274695(-) AGAAT-/GAAT  
            
    GGTTG
    2 -- int15Minor allele frequency- GAAT:0.01MN 404
    rs3009781,2
    C,F,O,A,H--87274769(+) AAGCCG/TTACAT 2 -- int130Minor allele frequency- T:0.38NA MN NS EA WA CSA 2870
    rs1491962361,2
    --87274879(+) ATCATA/CAAGTT 2 -- int10--------
    rs1423901991,2
    --87274926(+) TTTCCG/TTATAT 2 -- int10--------
    rs3009791,2
    C,F,O,A,H--87275025(+) AAGTAT/CGGTTA 2 -- int110Minor allele frequency- C:0.16NA WA CSA EA 508
    rs1511708401,2
    --87275026(+) AGTATC/GGTTAG 2 -- int10--------
    rs725508171,2
    C,F--87275199(-) TCATTA/TTATTG 2 -- int15Minor allele frequency- T:0.01MN 408
    rs3009801,2
    C,F,A--87275259(+) AAACAC/TATTTA 2 -- int117Minor allele frequency- T:0.20MN NA WA CSA EA 964
    rs1469417871,2
    --87275273(+) CTCAAA/GTGTTC 2 -- int10--------
    rs725492391,2
    F--87275378(-) AATGTT/-TTTAA 2 -- int15Minor allele frequency- -:0.01MN 408
    rs1148285831,2
    F--87275380(+) TAAAAC/TATTTG 2 -- int11Minor allele frequency- T:0.04WA 118
    rs1887782001,2
    --87275395(+) TCACTG/TTTATT 2 -- int10--------
    rs1379053421,2
    --87275654(+) ATGACC/GTACTA 2 -- int10--------
    rs1815069411,2
    --87275890(+) CTCTAA/GATTCT 2 -- int10--------
    rs1853612171,2
    --87275929(+) ACTTAC/TGCATG 2 -- int10--------
    rs3009811,2
    C,H--87275959(+) AATAAT/CAAAAG 2 -- int111Minor allele frequency- C:0.00MN NA WA CSA EA 555
    rs1116690011,2
    F--87276003(+) ATCAAC/TTCAAA 2 -- int12Minor allele frequency- T:0.05CSA WA 120
    rs1423049341,2
    --87276061(+) TTGCAC/TTTAAA 2 -- int10--------
    rs1897631671,2
    --87276195(+) AAAACA/CTATGT 2 -- int10--------
    rs1814174211,2
    --87276348(+) TTTAAA/GTGTCA 2 -- int10--------
    rs1859484541,2
    --87276408(+) AAAACC/TCTATT 2 -- int10--------
    rs1386339521,2
    C--87276410(+) AACTC-/TATTTTA 2 -- int10--------
    rs1899472691,2
    --87276744(+) TGGCAG/TGTTGG 2 -- int10--------
    rs1817804131,2
    --87276809(+) TAAAAG/TGAAAG 2 -- int10--------
    rs357978181,2
    C,F--87276833(-) TGATAG/CTTAAT 2 -- int15Minor allele frequency- C:0.01MN 404
    rs2003859971,2
    --87276879(+) GGTCAC/TATGTA 2 -- int10--------
    rs2017943031,2
    --87276925(+) TTGGTG/TGCATG 4 A syn10--------
    rs1461188491,2
    C--87276985(+) AGAGTG/TGCAGA 4 A syn10--------
    rs351821891,2,,4
    F--87276992(-) TGACGC/TCTCTG 4 A V mis17Minor allele frequency- T:0.01MN NA 412
    rs2008739151,2
    C--87277008(+) CAGAGG/CTATAA 4 /P /A mis11Minor allele frequency- C:0.00EU 1323
    rs49884591,2
    C,H--87277017(-) CTGATA/TCCTTT 4 T S mis1 ese39Minor allele frequency- T:0.00MN NS EA 814
    rs355606641,2
    C,F--87277021(-) TCGGCT/CGATAC 4 /A syn13Minor allele frequency- C:0.00NA EU 5937
    rs10516121,2,,4
    C,H--87277037(+) AAGCTT/CGGCAA 4 /Q /R mis113Minor allele frequency- C:0.15MN NS EA NA 1114
    rs2011564271,2
    --87277042(+) TGGCAA/GCTCAT 4 S syn10--------
    rs3009821,2
    C,F,A,H--87277188(+) GGTGCG/ACGCTA 2 -- us2k125Minor allele frequency- A:0.05MN NS EA NA 2618
    rs352866741,2
    C,F--87277203(-) TTGCAG/ATATAA 2 -- us2k15Minor allele frequency- A:0.01MN 408
    rs1388933451,2
    --87277216(+) AAATCC/TCTTTA 2 -- us2k10--------
    rs1912012541,2
    --87277407(+) TCAACA/CATTTT 2 -- us2k10--------
    rs341061481,2
    C,F--87277481(-) TTGTGT/CTAGTA 2 -- us2k15Minor allele frequency- C:0.01MN 396
    rs1885038401,2
    --87277578(+) ATACAC/TAATTT 2 -- us2k10--------
    rs105111341,2
    C,F,H--87277656(+) TAATGA/TTTCAT 2 -- us2k1 tfbs328Minor allele frequency- T:0.32NS NA EA MN CSA WA 1712
    rs1493033711,2
    --87277670(+) CAAAAA/GTGCAC 2 -- us2k10--------
    rs1445227571,2
    --87277697(+) GACAAC/TCAATA 2 -- us2k10--------
    rs1912756331,2
    --87277783(+) TGATTA/GCATTA 2 -- us2k10--------
    rs1483266301,2
    --87277790(+) ATTAAC/TGGCAA 2 -- us2k10--------
    rs351006421,2
    C,F--87278010(-) TGTGGC/AACAGA 2 -- us2k15Minor allele frequency- A:0.01MN 404
    rs1864687891,2
    --87278174(+) GAGTAC/TGTAAT 2 -- us2k10--------
    rs1414619771,2
    --87278259(+) TATTAA/TTGATG 2 -- us2k10--------
    rs356710751,2
    F--87278275(-) AATTAG/ATGTCT 2 -- us2k15Minor allele frequency- A:0.01MN 404
    rs340309961,2
    C,F--87278289(-) ATTCCG/ATAGTA 2 -- us2k18Minor allele frequency- A:0.02MN WA CSA 526
    rs1913142181,2
    --87278290(+) ACTACA/GGAATG 2 -- us2k10--------
    rs1463158001,2
    --87278474(+) CATATC/TTTTTC 2 -- us2k10--------
    rs1837596101,2
    --87278509(+) CTTTAA/TTAGTC 2 -- us2k10--------
    rs1877522581,2
    --87278578(+) CTGATA/CATTTT 2 -- us2k10--------
    rs1931293621,2
    --87278648(+) AAAATC/TAAATA 2 -- us2k10--------
    rs1394906901,2
    --87278822(+) AGATAC/TTTTAT 2 -- us2k10--------
    rs773022141,2
    F--87278837(+) TACCAT/GAAAAC 2 -- us2k11Minor allele frequency- G:0.01EA 120
    rs4194041,2
    H--87279034(-) TTCCAG/AATAAT 2 -- us2k14Minor allele frequency- A:0.00NS EA 420
    rs1852234581,2
    --87279130(+) TTGCAC/TTTTCA 2 -- us2k10--------
    rs353681341,2
    C,F--87308573(-) AACTT-/AAGAGN 2 -- ds50015Minor allele frequency- A:0.04MN 404
    rs38401971,2
    C,F--87308747(+) TACTC-/ATATGTC 2 -- ds50016Minor allele frequency- AT:0.10MN CSA 378
    rs3680618821,2
    C--87308904(+) TTTTT-/AAAAAA 4 -- ut310--------
    rs49884631,2
    C,F,A--87308905(-) TTTTTT/AAAAAA 2 -- ut312Minor allele frequency- A:0.13WA NA 238
    rs30528281,2
    C--87316743(+) GTTTA-/TTT   
       
    /TTTG
    TTTGT
    4 -- int1 cds11NA 2
    rs716195421,2
    C--87316743(+) GTTTATTTG/-  
            
    TTTGT
    2 -- int11Minor allele frequency- -:0.50NA 2
    rs2020133491,2
    C--87316746(+) TATTTA/GTTTGT 2 -- int10--------
    rs113398841,2
    C,F--87316830(+) TTAGCT/-CATTG 2 -- int15Minor allele frequency- -:0.50NA CSA 10
    rs113879581,2
    C--87317235(+) TTTTTT/-TTTTT 2 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs3730838241,2
    ----87271402(+) AACTCA/GATTTA 2 -- int10--------
    rs3692147701,2
    ----87263816(+) AAAAGC/GAAATA 2 -- int10--------
    rs284147051,2
    ----87265535(+) ATGGCA/CCTAAA 2 -- int12Minor allele frequency- C:0.00NA 4
    rs3730593281,2
    ----87275788(+) TTAAAA/TACAGA 2 -- int10--------
    rs3760476941,2
    ----87273481(+) GAGTCC/GCTAGC 2 -- int10--------
    rs2002497861,2
    ----87265311(+) GAGCAA/GCAAAA 2 -- int10--------
    rs3708815221,2
    ----87271897(+) TTAGAA/GTCTGA 2 -- int10--------
    rs3745284351,2
    ----87260972(+) CCAGAC/GGCACT 2 -- int10--------
    rs3727590971,2
    ----87270095(+) GGGCCA/GATAAA 2 -- int10--------
    rs3690578051,2
    ----87260097(+) TTTCTA/GTGATG 2 -- ds50010--------
    rs1470954371,2
    ----87264928(+) GTTCTC/GTGATT 4 T R mis11Minor allele frequency- G:0.00NA 4534
    rs3748531521,2
    ----87261878(+) TTCTTC/TGTTTT 4 Q R mis10--------
    rs3736387871,2
    ----87265997(+) TGCTTC/GCAGAT 2 -- int10--------
    rs3775187861,2
    ----87265171(+) GAAAGC/GGTTTT 2 -- int10--------
    rs3741319981,2
    ----87269311(+) TTGAGG/TCTGGA 2 -- int10--------
    rs3733038001,2
    ----87272430(+) TAAGAA/GACCAG 2 -- int10--------
    rs3685699041,2
    ----87260451(+) GAAACA/GGGAGA 2 -- ut310--------
    rs3725780581,2
    ----87272878(+) AAAGA-/TTTCT 
            
    TTCTT
    2 -- int10--------
    rs3718552361,2
    ----87269947(+) TGGTTC/TTTTAC 2 -- int10--------
    rs3711912231,2
    ----87264856(+) TTCCTC/GTTGCC 2 -- int10--------
    rs3703011381,2
    ----87268187(+) GTTTGC/TTTGCT 2 -- int10--------
    rs3741277851,2
    ----87268452(+) TTCCTA/GTAGTG 2 -- int10--------
    rs3757145441,2
    ----87264745(+) CATAAC/TGACTA 2 -- int10--------
    rs3749987291,2
    ----87261314(+) TCTCTC/TGAAAT 2 -- int10--------
    rs3698894001,2
    ----87266769(+) TTTAT-/TTTTTT 2 -- int10--------
    rs3695039541,2
    ----87270264(+) TTCAGC/TATAAC 2 -- int10--------
    rs3716202801,2
    ----87262628(+) TAAAAC/GCAGCA 2 -- int10--------
    rs3697391581,2
    ----87260336(+) GTTTC-/TTTTTT 4 -- ut310--------
    rs1447081081,2
    ----87260487(+) TCTTAT/CCTGCA 4 /R syn11Minor allele frequency- C:0.00NA 3990
    rs3719457901,2
    ----87278885(+) ACCAT-/GATATCTA 2 -- us2k10--------
    rs2003483701,2
    ----87267737(+) TTATTA/GTTTTC 2 -- int10--------
    rs3733341111,2
    ----87273831(+) AAGAAA/GTCAAA 2 -- int10--------
    rs1130566261,2
    ----87262568(+) AACCC-/CTCAAA 2 -- int11Minor allele frequency- C:0.00CSA 2
    rs3773926871,2
    ----87276898(+) TAGGAC/GCAGTA 2 -- int10--------
    rs3719493471,2
    ----87261248(+) TAGAC-/CCATGG 2 -- int10--------
    rs3724954151,2
    ----87263024(+) TCTTCC/TAGTTA 2 -- int10--------
    rs3703042351,2
    ----87269677(+) AGGAAC/TTGTAT 2 -- int10--------
    rs3713122851,2
    ----87261367(+) AGTGTG/TCTTGA 2 -- int10--------
    rs3703927821,2
    ----87277614(+) GAGAAG/TATATA 2 -- us2k10--------
    rs3711614691,2
    ----87261313(+) GTCTCC/TAGAAA 2 -- int