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POU1F1 Gene

protein-coding   GIFtS: 58
GCID: GC03M087307

POU Class 1 Homeobox 1

(Previous names: POU domain class 1, transcription factor 1)
(Previous symbol: PIT1)
  See POU1F1-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

POU Class 1 Homeobox 11 2     POU1F1a2
PIT11 2 3 5     Pit-12
Growth Hormone Factor 11 2 3     Pituitary-Specific Positive Transcription Factor 12
GHF-12 3     POU Domain, Class 1, Transcription Factor 12
CPHD12 5     GHF13
POU Domain Class 1, Transcription Factor 11     PIT-13

External Ids:    HGNC: 92101   Entrez Gene: 54492   Ensembl: ENSG000000648357   OMIM: 1731105   UniProtKB: P280693   

Export aliases for POU1F1 gene to outside databases

Previous GC identifiers: GC03M087883 GC03M090090 GC03M087188 GC03M087229 GC03M087391

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POU1F1 Gene:
This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The
protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations
in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for POU1F1 Gene:
POU1F1 (POU class 1 homeobox 1) is a protein-coding gene. Diseases associated with POU1F1 include pituitary hormone deficiency, combined 1, and pou1f1-related combined pituitary hormone deficiency. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PIT1_HUMAN, P28069
Function: Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope
phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds
to the consensus sequence 5'-TAAAT-3'

Gene Wiki entry for POU1F1 (Pituitary-specific positive transcription factor 1) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the POU1F1 gene promoter:
         Pax-5   p53   AP-1   ATF-2   CREB   deltaCREB   c-Jun   Ik-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOU1F1 promoter sequence
   Search Chromatin IP Primers for POU1F1

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU1F1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p11   Ensembl cytogenetic band:  3p11.2   HGNC cytogenetic band: 3p11.2

POU1F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU1F1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M087307:  view genomic region     (about GC identifiers)

87,308,554 bp from pter      End:
87,325,737 bp from pter
17,184 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: PIT1_HUMAN, P28069 (See protein sequence)
Recommended Name: Pituitary-specific positive transcription factor 1  
Size: 291 amino acids; 32912 Da
Sequence caution: Sequence=CAA54440.2; Type=Erroneous gene model prediction;
Secondary accessions: O75757 Q15132 Q15133 Q9UD34 Q9UEL3
Alternative splicing: 2 isoforms:  P28069-1   P28069-2   (Altered in its ability to trans-activate compared to isoform B)

Explore the universe of human proteins at neXtProt for POU1F1: NX_P28069

Explore proteomics data for POU1F1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POU1F1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000297.1  NP_001116229.1  

    ENSEMBL proteins: 
     ENSP00000263781   ENSP00000342931   ENSP00000454072   ENSP00000452610  

    POU1F1 Human Recombinant Protein Products:

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    Novus Biologicals POU1F1 Proteins
    Novus Biologicals POU1F1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    Search eBioscience for Proteins for POU1F1 

    antibodies-online proteins for POU1F1 (12 products) 

    antibodies-online peptides for POU1F1

    Search GeneTex for Proteins for POU1F1 

    POU1F1 Antibody Products:

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    antibodies-online antibodies for POU1F1 (9 products) 

    GeneTex Antibodies for POU1F1:  
                        POU1F1 Antibodies

    POU1F1 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for POU1F1 
    antibodies-online kits for POU1F1 (15 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    HGNC Gene Families:
    POU: Homeoboxes / POU class

    Selected InterPro protein domains (see all 7):
     IPR015586 Pit_1
     IPR010982 Lambda_DNA-bd_dom
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS

    Graphical View of Domain Structure for InterPro Entry P28069

    ProtoNet protein and cluster: P28069

    2 Blocks protein domains:
    IPB000327 POU domain
    IPB013847 POU

    UniProtKB/Swiss-Prot: PIT1_HUMAN, P28069
    Similarity: Belongs to the POU transcription factor family. Class-1 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain

    Find genes that share domains with POU1F1           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIT1_HUMAN, P28069
    Function: Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope
    phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds
    to the consensus sequence 5'-TAAAT-3'

         Genatlas biochemistry entry for POU1F1:
    POU domain,class 1,transcription factor 1,mammalian homeo box backfoot,Drosophila bicoid related,expressed in
    Rathke pouch,at an early stage of pituitary development and in a subset of adult anterior pituitary cells that
    express POMC,binding PITX2,reciprocally interacting with GATA2 for the mediation of signaling gradient-induced
    determination of pituitary cell types

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0001102RNA polymerase II activating transcription factor binding IPI12612071
    GO:0001105RNA polymerase II transcription coactivator activity IDA9685346
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    Find genes that share ontologies with POU1F1           About GenesLikeMe

         1 GenomeRNAi human phenotype for POU1F1:
     Decreased p24 protein expressi 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pou1f1):
     craniofacial  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system  reproductive system 

    Find genes that share phenotypes with POU1F1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for POU1F1

        Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study 

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for POU1F1

    Block miRNA regulation of human, mouse, rat POU1F1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate POU1F1:
    SwitchGear 3'UTR luciferase reporter plasmidPOU1F1 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for POU1F1
    Predesigned siRNA for gene silencing in human, mouse, rat POU1F1

    OriGene clones in human, mouse for POU1F1 (see all 11)
    OriGene ORF clones in mouse, rat for POU1F1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): POU1F1 (NM_001122757)
    Browse Sino Biological Human cDNA Clones
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU1F1

    Cell Line
    GenScript Custom overexpressing Cell Line Services for POU1F1
    Browse ESI BIO Cell Lines and PureStem Progenitors for POU1F1 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU1F1

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    PIT1_HUMAN, P28069: Nucleus
    Subcellular locations from COMPARTMENTS: 


    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with POU1F1           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for POU1F1 About    
    See pathways by source

    SuperPathContained pathways About
    1Glucocorticoid receptor regulatory network
    Glucocorticoid receptor regulatory network

    1 BioSystems Pathway for POU1F1
        Glucocorticoid receptor regulatory network

        Pathway & Disease-focused RT2 Profiler PCR Arrays including POU1F1: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Neurotoxicity in human mouse rat
              Homeobox (HOX) Genes in human mouse rat


        GeneGlobe Interaction Network for POU1F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for POU1F1 (P280692, 3 ENSP000003429314) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ETS1P149212, 3, ENSP000003764364MINT-14055 I2D: score=1 STRING: ENSP00000376436
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    NR3C1P041503, ENSP000002315094I2D: score=2 STRING: ENSP00000231509
    MED1Q156483, ENSP000003006514I2D: score=1 STRING: ENSP00000300651
    NR1I3Q149943, ENSP000003569594I2D: score=1 STRING: ENSP00000356959
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001708cell fate specification IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS1487156
    GO:0008284positive regulation of cell proliferation IEA--

    Find genes that share ontologies with POU1F1           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POU1F1 (PIT1)

    Selected Novoseek inferred chemical compound relationships for POU1F1 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ptx1 83.5 8 9514159 (2), 10859489 (2), 18079591 (1), 11027489 (1) (see all 5)
    acth 59.9 17 8890999 (3), 8739890 (3), 8949563 (2), 12780757 (1) (see all 10)
    forskolin 43 18 8625901 (4), 7961740 (3), 16879162 (1), 1584227 (1) (see all 5)
    bromocriptine 42.6 2 7621575 (1), 9207961 (1)
    ribonucleic acid 40.1 7 7608249 (2), 8869065 (2), 8733768 (1), 8784102 (1) (see all 5)
    cyclic amp 33.7 21 8645191 (4), 8625901 (2), 9751061 (2), 8524234 (2) (see all 7)
    estrogen 20.9 18 15221415 (3), 2379827 (2), 8733768 (1), 8424109 (1) (see all 12)
    dopamine 13.1 9 7706253 (3), 1835974 (3), 9167960 (1), 10449917 (1)
    okadaic acid 12.8 6 9717847 (3), 8232316 (1), 11266513 (1)
    arginine 12 4 9588494 (1), 12773133 (1), 9829213 (1)

    Find genes that share compounds with POU1F1           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for POU1F1 gene (2 alternative transcripts): 
    NM_000306.3  NM_001122757.2  

    Unigene Cluster for POU1F1:

    POU class 1 homeobox 1
    Hs.591654  [show with all ESTs]
    Unigene Representative Sequence: NM_001122757
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000350375(uc010hoj.1 uc003dqq.1) ENST00000344265 ENST00000561167
    Block miRNA regulation of human, mouse, rat POU1F1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate POU1F1:
    SwitchGear 3'UTR luciferase reporter plasmidPOU1F1 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for POU1F1
    Predesigned siRNA for gene silencing in human, mouse, rat POU1F1
    OriGene clones in human, mouse for POU1F1 (see all 11)
    OriGene ORF clones in mouse, rat for POU1F1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): POU1F1 (NM_001122757)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU1F1
    OriGene qSTAR qPCR primer pairs in human, mouse for POU1F1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POU1F1
      QuantiTect SYBR Green Assays in human, mouse, rat POU1F1
      QuantiFast Probe-based Assays in human, mouse, rat POU1F1

    Additional mRNA sequence: 

    D10216.1 L18781.1 X62429.1 X72215.1 

    2 DOTS entries:

    DT.206672  DT.91910385 

    8 AceView cDNA sequences:

    NM_000306 D10216 L18781 X72215 CD242816 CD237360 X62429 AV747622 

    GeneLoc Exon Structure

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU1F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    POU1F1 Expression
    About this image

    POU1F1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POU1F1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591654
        Pathway & Disease-focused RT2 Profiler PCR Arrays including POU1F1: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Neurotoxicity in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    OriGene qSTAR qPCR primer pairs in human, mouse for POU1F1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POU1F1
    QuantiTect SYBR Green Assays in human, mouse, rat POU1F1
    QuantiFast Probe-based Assays in human, mouse, rat POU1F1
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU1F1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for POU1F1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Pou1f11 , 5 POU domain, class 1, transcription factor 11, 5 87.74(n)1
      16 (37.25 cM)5
    187361  NM_008849.41  NP_032875.11 
    (Gallus gallus)
    Aves POU1F11 POU class 1 homeobox 1 78.4(n)
      374215  NM_204319.1  NP_989650.1 
    (Anolis carolinensis)
    Reptilia POU1F16
    POU class 1 homeobox 1
    1 ↔ 1
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pou1f11 POU class 1 homeobox 1 74.87(n)
      100492413  XM_002931760.2  XP_002931806.1 
    (Danio rerio)
    Actinopterygii pou1f11 POU domain, class 1, transcription factor 1 66.45(n)
      405777  NM_212851.1  NP_998016.1 
    (Caenorhabditis elegans)
    Secernentea ceh-66
    Protein CEH-6 (ceh-6) mRNA, complete cds
    1 ↔ 1
    I(8498114-8502412) WBGene00000431

    ENSEMBL Gene Tree for POU1F1 (if available)
    TreeFam Gene Tree for POU1F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for POU1F1 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F12  POU3F42  POU3F32  POU4F32  
    POU3F22  POU2F22  POU5F1B2  POU4F12  POU2F12  POU6F12  POU5F12  
    Selected SIMAP similar genes for POU1F1 using alignment to 3 protein entries:     PIT1_HUMAN (see all proteins) (see all similar genes):
    OCT6    POU6F1    POU5F1P4    POU3F1    POU3F4    POU4F1
    OCT-2    POU3F3    POU5F1    POU2F1    POU2F2    POU5F1P1
    POU3F2    POU2F3    POU5F1B    POU4F2    POU4F3    NKX2-5

    Find genes that share paralogs with POU1F1           About GenesLikeMe

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    Selected SNPs for POU1F1 (see all 468)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 3 posSequence#AA
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0037782 R Q mis40--------
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0634252 R Q mis40--------
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0105742 F C mis40--------
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0152602 W R mis40--------
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0037772 P L mis40--------
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0105762 P S mis40--------
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0037812 R W mis40--------
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0634272 E K mis40--------
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0105752 E G mis40--------
    Pituitary hormone deficiency, combined, 1 (CPHD1)4--see VAR_0037792 A P mis40--------

    HapMap Linkage Disequilibrium report for POU1F1 (87308554 - 87325737 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for POU1F1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv877133CNV Loss21882294
    nsv877134CNV Loss21882294
    nsv877135CNV Loss21882294
    nsv877132CNV Loss21882294
    nsv470749CNV Loss18288195
    nsv527279CNV Gain19592680
    nsv877136CNV Gain21882294

    Human Gene Mutation Database (HGMD): POU1F1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POU1F1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 173110   
    OMIM disorders: 613038  
    UniProtKB/Swiss-Prot: PIT1_HUMAN, P28069
  • Pituitary hormone deficiency, combined, 1 (CPHD1) [MIM:613038]: Combined pituitary hormone deficiency is
    defined as the impaired production of growth hormone and one or more of the other five anterior pituitary
    hormones. CPHD1 is characterized by pleiotropic deficiencies of growth hormone, prolactin and thyroid-stimulating
    hormone, while the production of adrenocorticotropic hormone, luteinizing hormone, and follicle-stimulating
    hormone are preserved. In infancy severe growth deficiency from birth as well as distinctive facial features with
    prominent forehead, marked midfacial hypoplasia with depressed nasal bridge, deep-set eyes, and a short nose with
    anteverted nostrils and hypoplastic pituitary gland by MRI examination can be seen. Some cases present with
    severe mental retardation along with short stature. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 18 diseases for POU1F1:    
    About MalaCards
    pituitary hormone deficiency, combined 1    pou1f1-related combined pituitary hormone deficiency    combined pituitary hormone deficiency    pituitary hypoplasia
    septo-optic dysplasia    axenfeld-rieger syndrome    pancreatic islet cell tumors    hypothyroidism due to deficient transcription factors involved in pituitary development or function
    prolactinoma    acth deficiency    isolated growth hormone deficiency    pituitary tumors
    hypopituitarism    blastoma    dwarfism    growth hormone deficiency
    borjeson-forssman-lehmann syndrome    hypothyroidism

    4 inferred disease relationships from the University of Copenhagen DISEASES database for POU1F1:
    Hypopituitarism     Pituitary hypoplasia     Holoprosencephaly     Hypothyroidism

    Find genes that share disorders with POU1F1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for POU1F1 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    panhypopituitarism 95.5 73 9632165 (2), 16263824 (2), 1472057 (2), 10698595 (2) (see all 56)
    tsh deficiency 91.6 14 9632165 (3), 16735499 (2), 18174732 (2), 9626142 (1) (see all 10)
    septo-optic dysplasia 85.1 1 15670191 (1)
    hormone deficiency 83.9 10 7920987 (2), 15844473 (1), 11222742 (1), 19407506 (1) (see all 9)
    pituitary adenoma 80.8 58 8834538 (4), 8148036 (4), 8246449 (3), 11081207 (3) (see all 26)
    hypopituitarism 79.4 9 1509263 (2), 18157385 (1), 10549299 (1), 9686002 (1) (see all 7)
    dwarfism pituitary 74 1 7920987 (1)
    acth deficiency 70.5 3 12780757 (1), 17162714 (1), 15928241 (1)
    pituitary tumors 70.2 10 11081157 (2), 16189248 (2), 8027225 (1), 10404841 (1) (see all 6)
    prolactin deficiency 67.8 1 9627600 (1)

    Genetic Association Database (GAD): POU1F1
    Human Genome Epidemiology (HuGE) Navigator: POU1F1 (14 documents)

    Export disorders for POU1F1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU1F1 gene, integrated from 10 sources (see all 358) (see top 10):
    (articles sorted by number of sources associating them with POU1F1)

    1. Novel mutations within the POU1F1 gene associated with variable combined pituitary hormone deficiency. (PubMed id 15928241)1, 2, 4, 9 Turton J.P.G.... Dattani M.T. (J. Clin. Endocrinol. Metab. 2005)
    2. Cloning of the human cDNA for transcription factor Pit-1. (PubMed id 1956794)1, 2, 3 Lew A.M. and Elsholtz H.P. (Nucleic Acids Res. 1991)
    3. Positive association between POU1F1 and mental retardation in young females in the Chinese Han population. (PubMed id 16505001)1, 4, 9 Sun Y....He L. (Hum. Mol. Genet. 2006)
    4. Central hypothyroidism reveals compound heterozygous mutations in the Pit-1 gene. (PubMed id 9485179)1, 2, 9 Brown M.R.... Hurley D.L. (Horm. Res. 1998)
    5. Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency. (PubMed id 1472057)1, 2, 9 Ohta K.... Matsuda I. (Biochem. Biophys. Res. Commun. 1992)
    6. Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. (PubMed id 16214911)1, 4, 9 Canzian F....Kaaks R. (amp 2005)
    7. Combined pituitary hormone deficiency caused by compound heterozygosity for two novel mutations in the POU domain of the PIT1/POU1F1 gene. (PubMed id 11297581)1, 2, 9 Hendriks-Stegeman B.I.... Jansen M. (J. Clin. Endocrinol. Metab. 2001)
    8. Pro239Ser: a novel recessive mutation of the Pit-1 gene in seven Middle Eastern children with growth hormone, prolactin, and thyrotropin deficiency. (PubMed id 9626142)1, 2, 9 Pernasetti F.M.... Martial J.A. (J. Clin. Endocrinol. Metab. 1998)
    9. A new mutation of the gene encoding the transcription factor Pit-1 is responsible for combined pituitary hormone deficiency. (PubMed id 8768831)1, 2, 9 Pellegrini-Bouiller I.... Enjalbert A. (J. Clin. Endocrinol. Metab. 1996)
    10. A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency. (PubMed id 1509262)1, 2, 9 Radovick S....Wondisford F.E. (Science 1992)
    11. Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia. (PubMed id 1509263)1, 2, 9 Pfaeffle R.W....Ingraham H.A. (Science 1992)
    12. Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion. (PubMed id 20534763)1, 4 Dateki S....Ogata T. (J. Clin. Endocrinol. Metab. 2010)
    13. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    14. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    15. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (Hum. Mol. Genet. 2010)
    16. Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. (PubMed id 20810604)1, 4 Gu F....Kraft P. (amp 2010)
    17. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    18. Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function. (PubMed id 18514160)1, 4 Arnaud-Lopez L....Naitza S. (Am. J. Hum. Genet. 2008)
    19. A novel pituitary transcription factor is produced by alternative splicing of the human GHF-1/PIT-1 gene. (PubMed id 7721104)1, 2 Delhase M.... Castrillo J.-L. (Gene 1995)
    20. Cloning of a human GHF-1/Pit-1 cDNA variant. (PubMed id 8346040)1, 2 Pernasetti F.M.... Martial J.A. (Nucleic Acids Res. 1993)
    21. Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1. (PubMed id 1487156)1, 2 Ohta K.... Matsuda I. (Gene 1992)
    22. Nucleotide sequence of the complementary DNA for human Pit-1/GHF-1. (PubMed id 1370379)1, 2 Tatsumi K.I.... Miyai K. (Biochim. Biophys. Acta 1992)
    23. Pit-1 is expressed in normal and tumorous human breast and regulates GH secretion and cell proliferation. (PubMed id 16061841)1, 9 Gil-Puig C....Perez-Fernandez R. (Eur. J. Endocrinol. 2005)
    24. The role of CBP/p300 interactions and Pit-1 dimerization in the pathophysiological mechanism of combined pituitary hormone deficiency. (PubMed id 16263824)1, 9 Cohen R.N....Radovick S. (J. Clin. Endocrinol. Metab. 2006)
    25. Expression of Pit-1 in nonsomatotrope cell lines induces human growth hormone locus control region histone modification and hGH-N transcription. (PubMed id 19427323)1, 9 Hogan K.A....Shewchuk B.M. (J. Mol. Biol. 2009)
    26. The Pit-1/Pou1f1 transcription factor regulates and correlates with prolactin expression in human breast cell lines and tumors. (PubMed id 19808898)1, 9 Ben-Batalla I....Perez-Fernandez R. (Endocr. Relat. Cancer 2010)
    27. Expression of the synaptotagmin I gene is enhanced by binding of the pituitary-specific transcription factor, POU1F1. (PubMed id 19608642)1, 9 Howard P.W....Maurer R.A. (Mol. Endocrinol. 2009)
    28. The vitamin D receptor represses transcription of the pituitary transcription factor Pit-1 gene without involvement of the retinoid X receptor. (PubMed id 16322098)1, 9 Seoane S. and Perez-Fernandez R. (Mol. Endocrinol. 2006)
    29. Involvement of the pituitary-specific transcription factor pit-1 in somatolactotrope cell growth and death: an approach using dominant-negative pit-1 mutants. (PubMed id 16901973)1, 9 Pellegrini I....Franc J.L. (Mol. Endocrinol. 2006)
    30. The R271W mutant form of Pit-1 does not act as a dominant inhibitor of Pit-1 action to activate the promoters of GH and prolactin genes. (PubMed id 12773133)1, 9 Kishimoto M....Chihara K. (Eur. J. Endocrinol. 2003)
    31. Novel function of the transactivation domain of a pituitary-specific transcription factor, Pit-1. (PubMed id 12200420)1, 9 Kishimoto M....Chihara K. (J. Biol. Chem. 2002)
    32. Expression of pit-1 messenger ribonucleic acid and protein in the human placenta. (PubMed id 7608249)1, 9 Bamberger A.M....Asa S.L. (J. Clin. Endocrinol. Metab. 1995)
    33. Cellular expression levels of the vitamin D receptor are critical to its transcriptional regulation by the pituitary transcription factor Pit-1. (PubMed id 17456792)1, 9 Seoane S....Perez-Fernandez R. (Mol. Endocrinol. 2007)
    34. Functional interactions with Pit-1 reorganize co-repressor complexes in the living cell nucleus. (PubMed id 16030140)1, 9 Voss T.C....Day R.N. (J. Cell. Sci. 2005)
    35. A 'hot spot' in the Pit-1 gene responsible for combined pituitary hormone deficiency: clinical and molecular correlates. (PubMed id 7852536)2, 9 Cohen L.E.... Radovick S. (J. Clin. Endocrinol. Metab. 1995)
    36. Identification and analysis of prophet of Pit-1-binding sites in human Pit-1 gene. (PubMed id 18653712)1, 9 Ikeshita N....Okimura Y. (Endocrinology 2008)
    37. MED220/thyroid receptor-associated protein 220 functions as a transcriptional coactivator with Pit-1 and GATA-2 on the thyrotropin-beta promoter in thyrotropes. (PubMed id 16396960)1, 9 Gordon D.F....Ridgway E.C. (Mol. Endocrinol. 2006)
    38. Expression of Pit-1 and growth hormone-releasing hormone receptor mRNA in human pituitary adenomas: difference among functioning, silent, and other nonfunctioning adenomas. (PubMed id 12165656)1, 9 Kobayashi I....Kameya T. (Endocr. Pathol. 2002)
    39. Pit-1 gene expression in the human pituitary and pituitary adenomas. (PubMed id 8027225)1, 9 Pellegrini I.... Jaquet P. (J. Clin. Endocrinol. Metab. 1994)
    40. The transcription factor Pit-1/GHF-1 is expressed in hemopoietic and lymphoid tissues. (PubMed id 8458380)1, 9 Delhase M....Hooghe R.J. (Eur. J. Immunol. 1993)
    41. A novel nonsense mutation in the Pit-1 gene: evidence for a gene dosage effect. (PubMed id 12629113)1, 9 Hashimoto Y....Cohen L.E. (J. Clin. Endocrinol. Metab. 2003)
    42. Clinical characteristics and molecular analysis of PIT1, PROP1,LHX3, and HESX1 in combined pituitary hormone deficiency patients with abnormal pituitary MR imaging. (PubMed id 14646405)1, 9 Kim S.S....Yoo H.W. (Horm. Res. 2003)
    43. Combined pituitary hormone deficiency due to the F135C human Pit-1 (pituitary-specific factor 1) gene mutation: functional and structural correlates. (PubMed id 11222742)1, 9 Vallette-Kasic S....Brue T. (Mol. Endocrinol. 2001)
    44. The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities. (PubMed id 9685346)1, 9 Amendt B.A....Russo A.F. (J. Biol. Chem. 1998)
    45. The glucocorticoid receptor inhibits the human prolactin gene expression by interference with Pit-1 activity. (PubMed id 9426156)1, 9 Nalda A.M....Muller M. (Mol. Cell. Endocrinol. 1997)
    46. Pituitary dwarfism in the R271W Pit-1 gene mutation. (PubMed id 9392392)1, 9 Aarskog D....Myking O.L. (Eur. J. Pediatr. 1997)
    47. Monoallelic expression of normal mRNA in the PIT1 mutation heterozygotes with normal phenotype and biallelic expression in the abnormal phenotype. (PubMed id 7833912)1, 9 Okamoto N....Tatsumi K. (Hum. Mol. Genet. 1994)
    48. Functional relationship between LHX4 and POU1F1 in light of the LHX4 mutation identified in patients with pituitary defects. (PubMed id 15998782)1, 9 Machinis K. and Amselem S. (J. Clin. Endocrinol. Metab. 2005)
    49. Activin inhibits pituitary prolactin expression and cell growth through Smads, Pit-1 and menin. (PubMed id 15031321)1, 9 Lacerte A....Lebrun J.J. (Mol. Endocrinol. 2004)
    50. Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency. (PubMed id 12717343)1, 9 Rodriguez R. and Andersen B. (Minerva Endocrinol. 2003)
    51. A novel mutation in PIT-1: phenotypic variability in familial combined pituitary hormone deficiencies. (PubMed id 11924936)1, 9 Gat-Yablonski G....Phillip M. (amp 2002)
    52. Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. (PubMed id 11891224)1, 9 Gonzalez M.M. and Carlberg C. (J. Biol. Chem. 2002)
    53. Structural characterization of the PIT-1/ETS-1 interaction: PIT-1 phosphorylation regulates PIT-1/ETS-1 binding. (PubMed id 12242337)1, 9 Augustijn K.D....van der Vliet P.C. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    54. Transcription factors regulating pituitary development. (PubMed id 10549299)1, 9 Parks J.S. and Brown M.R. (amp 1999)
    55. Signal-specific co-activator domain requirements for Pit-1 activation. (PubMed id 9751061)1, 9 Xu L....Rosenfeld M.G. (Nature 1998)
    56. Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression. (PubMed id 9032233)1, 9 Bradford A.P....Gutierrez-Hartmann A. (Mol. Cell. Biol. 1997)
    57. A novel E250X mutation of the PIT1 gene in a patient with combined pituitary hormone deficiency. (PubMed id 7670563)1, 9 Irie Y....Amino N. (Endocr. J. 1995)
    58. W194XProp1 and S156insTProp1, both of which have intact DNA-binding domain, show a different DNA-binding activity to the Prop1-binding element in human Pit-1 gene. (PubMed id 20381582)1, 9 Shibahara H....Okimura Y. (Mol. Cell. Endocrinol. 2010)
    59. A novel germline mutation, IVS4+1G&gt;A, of the POU1F1 gene underlying combined pituitary hormone deficiency. (PubMed id 18059085)1, 9 Snabboon T....Shotelersuk V. (Horm. Res. 2008)
    60. Pituitary transcription factors: from congenital deficiencies to gene therapy. (PubMed id 16879162)1, 9 Quentien M.H....Enjalbert A. (J. Neuroendocrinol. 2006)
    61. Identification and functional analysis of the novel S179R POU1F1 mutation associated with combined pituitary hormone deficiency. (PubMed id 16968807)2, 9 Miyata I.... Brue T. (J. Clin. Endocrinol. Metab. 2006)
    62. Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line. (PubMed id 16133148)1, 9 Miyai S....Osamura R.Y. (Cell Tissue Res. 2005)
    63. New N-terminal located mutation (Q4ter) within the POU1F1-gene (PIT-1) causes recessive combined pituitary hormone deficiency and variable phenotype. (PubMed id 12932747)1, 9 Salemi S....Mullis P.E. (amp 2003)
    64. Pitx factors are involved in basal and hormone-regulated activity of the human prolactin promoter. (PubMed id 12223489)1, 9 Quentien M.H....Pellegrini I. (J. Biol. Chem. 2002)
    65. A new C-terminal located mutation (V272ter) in the PIT-1 gene manifesting with severe congenital hypothyroidism. Possible functionality of the PIT-1 C-terminus. (PubMed id 11847467)1, 9 Blankenstein O....Heimann G. (Horm. Res. 2001)
    66. Description of a Brazilian patient bearing the R271W Pit-1 gene mutation. (PubMed id 9588494)1, 9 Rodrigues Martineli A.M....Graf H. (Thyroid 1998)
    67. P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development. (PubMed id 8755540)1, 9 Szeto D.P....Rosenfeld M.G. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    68. The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency. (PubMed id 7593413)1, 9 de Zegher F....Martial J.A. (J. Clin. Endocrinol. Metab. 1995)
    69. Cretinism with combined hormone deficiency caused by a mutation in the PIT1 gene. (PubMed id 1302000)1, 9 Tatsumi K....Kohno H. (Nat. Genet. 1992)
    70. PIT1 upregulation by HMGA proteins has a role in pituitary tumorigenesis. (PubMed id 22199144)1 Palmieri D....Fedele M. (Endocr. Relat. Cancer 2012)
    71. POU1F1-mediated activation of hGH-N by deoxyribonuclease I hypersensitive site II of the human growth hormone locus control region. (PubMed id 22094313)1 Hunsaker T.L....Shewchuk B.M. (J. Mol. Biol. 2012)
    72. Identification of a novel mutation in the exon 2 splice donor site of the POU1F1/PIT-1 gene in Japanese identical twins with mild combined pituitary hormone deficiency. (PubMed id 21722153)1 Inoue H....Fujieda K. (Clin. Endocrinol. (Oxf) 2012)
    73. Research resource: A genome-wide study identifies potential new target genes for POU1F1. (PubMed id 22638072)1 Herman J.P....Franc J.L. (Mol. Endocrinol. 2012)
    74. A novel POU1F1 mutation (p.Thr168IlefsX7) associated with an early and severe form of combined pituitary hormone deficiency: functional analysis and follow-up from infancy to adulthood. (PubMed id 21521297)1 Tenenbaum-Rakover Y....Amselem S. (Clin. Endocrinol. (Oxf) 2011)
    75. CEBPD suppresses prolactin expression and prolactinoma cell proliferation. (PubMed id 21980073)1 Tong Y....Melmed S. (Mol. Endocrinol. 2011)
    76. Pit-1 mutation and lipoedema in a family. (PubMed id 19609847)1 Bano G....Nussey S. (amp 2010)
    77. Appearance of the pituitary factor Pit-1 increases chromatin remodeling at hypersensitive site III in the human GH locus. (PubMed id 20395397)1 Yang X....Cattini P.A. (J. Mol. Endocrinol. 2010)
    78. CTNNB1 gene mutations, pituitary transcription factors, and MicroRNA expression involvement in the pathogenesis of adamantinomatous craniopharyngiomas. (PubMed id 21761366)1 Campanini Castro M. (amp 2010)
    79. A Pit-1 threonine 220 phosphomimic reduces binding to monomeric DNA sites to inhibit Ras and estrogen stimulation of the prolactin gene promoter. (PubMed id 19887646)1 Jean A....Duval D.L. (Mol. Endocrinol. 2010)
    80. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    81. Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis. (PubMed id 21060149)1 Ben-Batalla I....Perez-Fernandez R. (J. Clin. Invest. 2010)
    82. The 26-amino acid beta-motif of the Pit-1beta transcription factor is a dominant and independent repressor domain. (PubMed id 19556346)1 Jonsen M.D....Gutierrez-Hartmann A. (Mol. Endocrinol. 2009)
    83. The CPPDD-associated ANKH M48T mutation interrupts the interaction of ANKH with the sodium/phosphate cotransporter PiT-1. (PubMed id 19369455)1 Wang J....Tsui F.W. (J. Rheumatol. 2009)
    84. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    85. Identification of host proteins required for HIV infection through a functional genomic screen. (PubMed id 18187620)1 Brass A.L....Elledge S.J. (Science 2008)
    86. Sodium-dependent phosphate cotransporters and vascular calcification. (PubMed id 17565274)1 Li X. and Giachelli C.M. (Curr. Opin. Nephrol. Hypertens. 2007)
    87. Differential utilization of transcription activation subdomains by distinct coactivators regulates Pit-1 basal and Ras responsiveness. (PubMed id 17021049)1 Duval D.L....Gutierrez-Hartmann A. (Mol. Endocrinol. 2007)
    88. Activin inhibits the human Pit-1 gene promoter through the p38 kinase pathway in a Smad-independent manner. (PubMed id 16740974)1 de Guise C....Lebrun J.J. (Endocrinology 2006)
    89. Regulation of the human growth hormone gene family: possible role for Pit-1 in early stages of pituitary-specific expression and repression. (PubMed id 17047377)1 Cattini P.A....Detillieux K.A. (Neuroendocrinology 2006)
    90. Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene. (PubMed id 14714741)1 Dattani M.T. (amp 2003)
    91. Dominant negative dimerization of a mutant homeodomain protein in Axenfeld-Rieger syndrome. (PubMed id 12612071)1 Saadi I....Russo A.F. (Mol. Cell. Biol. 2003)
    92. Specification of unique Pit-1 activity in the hGH locus control region. (PubMed id 12189206)1 Shewchuk B.M....Cooke N.E. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    93. Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. (PubMed id 10367888)1 Dasen J.S....Rosenfeld M.G. (Cell 1999)
    94. Structure and regulation of the human growth hormone-releasing hormone receptor gene. (PubMed id 9482665)1 Petersenn S....Schulte H.M. (Mol. Endocrinol. 1998)
    95. Nuclear factor 1 regulates the distal silencer of the human PIT1/GHF1 gene. (PubMed id 9639565)1 Rajas F....Hooghe-Peters E.L. (Biochem. J. 1998)
    96. The c-Jun delta-domain inhibits neuroendocrine promoter activity in a DNA sequence- and pituitary-specific manner. (PubMed id 8663380)1 Farrow K.N....Gutierrez-Hartmann A. (J. Biol. Chem. 1996)
    97. Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression. (PubMed id 8370519)1 Lipkin S.M....Rosenfeld M.G. (amp 1993)
    98. Expression of a large family of POU-domain regulatory genes in mammalian brain development. (PubMed id 2739723)1 He X....Rosenfeld M.G. (Nature 1989)
    99. The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. (PubMed id 2902927)1 Bodner M....Karin M. (Cell 1988)
    100. The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. (PubMed id 3215510)1 Herr W....Ruvkun G. (amp 1988)
    101. Cloning of the full length pig PIT1 (POU1F1) CDNA and a novel alternative PIT1 transcript, and functional studies of their encoded proteins. (PubMed id 11370678)9 Yu T.P....Tuggle C.K. (Anim. Biotechnol. 2001)
    102. Pit-1 gene expression in human pituitary adenomas. (PubMed id 9167960)9 Pellegrini-Bouiller I....Jaquet P. (Horm. Res. 1997)
    103. The ontogeny of pit-1 expression in the human fetal pituitary gland. (PubMed id 8739890)9 Puy L.A. and Asa S.L. (Neuroendocrinology 1996)
    104. [Homeoproteins and pituitary adenoma]. (PubMed id 9207961)9 Barlier A....Enjalbert A. (Ann. Endocrinol. (Paris) 1997)
    105. Thyroid hormone receptor beta2 promoter activity in pituitary cells is regulated by Pit-1. (PubMed id 8798664)9 Wood W.M....Ridgway E.C. (J. Biol. Chem. 1996)
    106. Pit-1 gene expression in human pituitary adenomas using the reverse transcription polymerase chain reaction method. (PubMed id 8949563)9 Yamada S....Usui M. (Clin. Endocrinol. (Oxf) 1996)
    107. Constitutively active G(S) alpha-subunits stimulate Pit-1 promoter activity via a protein kinase A-mediated pathway acting through deoxyribonucleic acid binding sites both for Pit-1 and for adenosine 3',5'-monophosphate response element-binding protein. (PubMed id 8625901)9 Gaiddon C....Bancroft C. (Endocrinology 1996)
    108. In situ hybridization analysis of Pit-1 mRNA and hormonal production in human pituitary adenomas. (PubMed id 8834538)9 Sanno N....Osamura R.Y. (Acta Neuropathol. 1996)
    109. Imaging the localized protein interactions between Pit-1 and the CCAAT/enhancer binding protein alpha in the living pituitary cell nucleus. (PubMed id 12554785)9 Day R.N....Schaufele F. (Mol. Endocrinol. 2003)
    110. Correlation of Pit-1 gene expression and Pit-1 content with proliferation and differentiation in human myeloid leukemic cells. (PubMed id 9828108)9 Costoya J.A....Devesa J. (Exp. Cell Res. 1998)
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    240. GHRH proliferative action on somatotrophs is cell-type specific and dependent on Pit-1/GHF-1 expression. (PubMed id 17941086)9 Solloso A....Pombo C.M. (J. Cell. Physiol. 2008)
    241. Regulation of growth hormone expression by Delta-like protein 1 (Dlk1). (PubMed id 17485162)9 Ansell P.J....Klibanski A. (Mol. Cell. Endocrinol. 2007)
    242. MRI findings and genotype analysis in patients with childhood onset growth hormone deficiency--correlation with severity of hypopituitarism. (PubMed id 17642419)9 Zimmermann A....Bettendorf M. (amp 2007)
    243. Stromal cells of endometriosis fail to produce paracrine factors that induce epithelial 17beta-hydroxysteroid dehydrogenase type 2 gene and its transcriptional regulator Sp1: a mechanism for defective estradiol metabolism. (PubMed id 17403431)9 Cheng Y.H....Bulun S.E. (Am. J. Obstet. Gynecol. 2007)
    244. Essential role of GATA2 in the negative regulation of thyrotropin beta gene by thyroid hormone and its receptors. (PubMed id 17244762)9 Matsushita A....Nakamura H. (Mol. Endocrinol. 2007)
    245. Expression of adrenocorticotropic hormone, prolactin and transcriptional factors in clinically nonfunctioning pituitary adenoma. (PubMed id 18079591)9 Kageyama K....Suda T. (Endocr. J. 2007)
    246. Autocrine prolactin promotes prostate cancer cell growth via Janus kinase-2-signal transducer and activator of transcription-5a/b signaling pathway. (PubMed id 17412813)9 Dagvadorj A....Nevalainen M.T. (Endocrinology 2007)
    247. Hypothalamic and pituitary development: novel insights into the aetiology. (PubMed id 17785694)9 Kelberman D. and Dattani M.T. (Eur. J. Endocrinol. 2007)
    248. Genetics of growth hormone deficiency. (PubMed id 17336732)9 Mullis P.E. (Endocrinol. Metab. Clin. North Am. 2007)
    249. Panhypopituitarism: genetic versus acquired etiological factors. (PubMed id 17315526)9 Coya R....Martul P. (amp 2007)
    250. [Combined deficiency of TSH, GH, and PRL (PIT1 abnormality and PROP1 abnormality)]. (PubMed id 16776098)9 Tatsumi K.I. (Nippon Rinsho 2006)
    251. Long-term follow-up of combined pituitary hormone deficiency in two siblings with a Prophet of Pit-1 gene mutation. (PubMed id 17162714)9 Georgopoulos N.A....Panidis D. (Gynecol. Endocrinol. 2006)
    252. Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. (PubMed id 16678101)9 Olson L.E....Rosenfeld M.G. (Cell 2006)
    253. B29 gene silencing in pituitary cells is regulated by its 3' enhancer. (PubMed id 16920149)9 Malone C.S....Wall R. (J. Mol. Biol. 2006)
    254. Identification of transcriptional regulators of neuropeptide FF gene expression. (PubMed id 16515822)9 Nystedt J.M....Panula P. (Peptides 2006)
    255. A variation in a Pit-1 site in the growth hormone gene (GH1) promoter induces a differential transcriptional activity. (PubMed id 16517055)9 Giordano M....Momigliano-Richiardi P. (Mol. Cell. Endocrinol. 2006)
    256. Estrogen-receptor-alpha exchange and chromatin dynamics are ligand- and domain-dependent. (PubMed id 16968748)9 Sharp Z.D....Mancini M.A. (J. Cell. Sci. 2006)
    257. Fibroblast growth factor 2 and cyclic AMP synergistically regulate bone sialoprotein gene expression. (PubMed id 16466682)9 Shimizu E....Ogata Y. (Bone 2006)
    258. Examination of the direct effects of metabolic factors on somatotrope function in a non-human primate model, Papio anubis. (PubMed id 16901921)9 Luque R.M....Kineman R.D. (J. Mol. Endocrinol. 2006)
    259. Mutation analysis of POUF-1, PROP-1 and HESX-1 show low frequency of mutations in children with sporadic forms of combined pituitary hormone deficiency and septo-optic dysplasia. (PubMed id 15670191)9 Rainbow L.A....Kirk J.M. (Clin. Endocrinol. (Oxf) 2005)
    260. EGF stimulates Pit-1 independent transcription of the human prolactin pituitary promoter in human breast cancer SK-BR-3 cells through its proximal AP-1 response element. (PubMed id 15607537)9 Manfroid I....Muller M. (Mol. Cell. Endocrinol. 2005)
    261. Serine/threonine/tyrosine phosphorylation of the LHX3 LIM-homeodomain transcription factor. (PubMed id 15517599)9 Parker G.E.... Rhodes S.J. (J. Cell. Biochem. 2005)
    262. Menin and TGF-beta superfamily member signaling via the Smad pathway in pituitary, parathyroid and osteoblast. (PubMed id 16001330)9 Hendy G.N....Canaff L. (Horm. Metab. Res. 2005)
    263. Stimulatory effect of interleukin-1beta on growth hormone gene expression and growth hormone release from rat GH3 cells. (PubMed id 16043966)9 Gong F.Y....Shi Y.F. (Neuroendocrinology 2005)
    264. Recent progress in studies of pituitary tumor pathogenesis. (PubMed id 16311408)9 Minematsu T....Osamura R.Y. (Endocrine 2005)
    265. Growth hormone deficiency and combined pituitary hormone deficiency: does the genotype matter? (PubMed id 16060904)9 Dattani M.T. (Clin. Endocrinol. (Oxf) 2005)
    266. The zinc finger Ikaros transcription factor regulates pituitary growth hormone and prolactin gene expression through distinct effects on chromatin accessibility. (PubMed id 15618287)9 Ezzat S....Asa S.L. (Mol. Endocrinol. 2005)
    267. Genetic basis of short stature. (PubMed id 16114273)9 Castro-FeijA^o L....Pombo M. (J. Endocrinol. Invest. 2005)
    268. Clinical and molecular features of a TSH-secreting pituitary microadenoma. (PubMed id 16379036)9 Usui T....Naruse M. (Pituitary 2005)
    269. Molecular pathology of the pituitary. Development and functional differentiation of pituitary adenomas. (PubMed id 15281338)9 Osamura R.Y....Teramoto A. (Front Horm Res 2004)
    270. Conserved amino acid sequences confer nuclear localization upon the Prophet of Pit-1 pituitary transcription factor protein. (PubMed id 15246537)9 Guy J.C....Rhodes S.J. (Gene 2004)
    271. Cooperative dimerization of the POU domain protein Brn-2 on a new motif activates the neuronal promoter of the human aromatic L-amino acid decarboxylase gene. (PubMed id 14741405)9 Dugast-Darzacq C....Weber M.J. (Brain Res. Mol. Brain Res. 2004)
    272. Pituitary hormone deficiencies due to transcription factor gene alterations. (PubMed id 15519252)9 Reynaud R....Brue T. (amp 2004)
    273. Familial combined pituitary hormone deficiency due to a novel mutation R99Q in the hot spot region of Prophet of Pit-1 presenting as constitutional growth delay. (PubMed id 12519826)9 Vieira T.C.... Abucham J. (J. Clin. Endocrinol. Metab. 2003)
    274. Identification of adrenocorticotropin receptor messenger ribonucleic acid in the human pituitary and its loss of expression in pituitary adenomas. (PubMed id 14671214)9 Morris D.G....Grossman A.B. (J. Clin. Endocrinol. Metab. 2003)
    275. TCF and Groucho-related genes influence pituitary growth and development. (PubMed id 12907761)9 Brinkmeier M.L....Camper S.A. (Mol. Endocrinol. 2003)
    276. Familial combined pituitary hormone deficiency caused by PROP-1 gene mutation. Growth patterns and MRI studies in untreated subjects. (PubMed id 12006708)9 Crone J....Frisch H. (Horm. Res. 2002)
    277. Differential nuclear receptor signalling from DR4-type response elements. (PubMed id 12210766)9 Quack M....Carlberg C. (J. Cell. Biochem. 2002)
    278. Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region. (PubMed id 11923475)9 Ozawa A.... Mori M. (Mol. Endocrinol. 2002)
    279. Genetic defects in the development and function of the anterior pituitary gland. (PubMed id 12173688)9 Cushman L.J....Rhodes S.J. (Ann. Med. 2002)
    280. A unique case of combined pituitary hormone deficiency caused by a PROP1 gene mutation (R120C) associated with normal height and absent puberty. (PubMed id 12153609)9 Arroyo A....Mellon P.L. (Clin. Endocrinol. (Oxf) 2002)
    281. Foetal and neonatal thyroid disorders. (PubMed id 12244277)9 Radetti G....Bona G. (Minerva Pediatr. 2002)
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    283. A case of Cushing's disease caused by pituitary adenoma producing adrenocorticotropic hormone and growth hormone concomitantly: aberrant expression of transcription factors NeuroD1 and Pit-1 as a proposed mechanism. (PubMed id 12379758)9 Tahara S....Osamura R.Y. (Mod. Pathol. 2002)
    284. Pseudotumor of the pituitary due to PROP-1 deletion. (PubMed id 11822586)9 Teinturier C....BougnA"res P.F. (amp 2002)
    285. Differential activity by DNA-induced quarternary structures of POU transcription factors. (PubMed id 12213595)9 RemAcnyi A....Wilmanns M. (Biochem. Pharmacol. 2002)
    286. Cloning and characterization of the 5'-flanking region of the canine growth hormone gene. (PubMed id 12431806)9 Lantinga-van Leeuwen I.S....Mol J.A. (Mol. Cell. Endocrinol. 2002)
    287. Isolated growth hormone deficiency in children and adolescents. (PubMed id 11529396)9 Argente J....Skordis N. (amp 2001)
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    290. Inhibition of protein phosphatase PP1 in GH3B6, but not in GH3 cells, activates the MEK/ERK/c-fos pathway and the human prolactin promoter, involving the coactivator CPB/p300. (PubMed id 11266513)9 Manfroid I....Muller M. (Mol. Endocrinol. 2001)
    291. A point mutation in the LIM domain of Lhx3 reduces activation of the glycoprotein hormone alpha-subunit promoter. (PubMed id 11279219)9 Howard P.W. and Maurer R.A. (J. Biol. Chem. 2001)
    292. Review: molecular thyroidology. (PubMed id 11508826)9 Winter W.E. and Signorino M.R. (Ann. Clin. Lab. Sci. 2001)
    293. Combined pituitary hormone deficiency and pituitary hypoplasia due to a mutation of the Pit-1 gene. (PubMed id 10792348)9 Frisch H....PfAoffle R. (Clin. Endocrinol. (Oxf) 2000)
    294. Impaired adrenocorticotropin-adrenal axis in combined pituitary hormone deficiency caused by a two-base pair deletion (301-302delAG) in the prophet of Pit-1 gene. (PubMed id 10634415)9 Pernasetti F....Mellon P.L. (J. Clin. Endocrinol. Metab. 2000)
    295. [Pituitary development and pathology of transcription factors]. (PubMed id 10970945)9 Barlier A....Brue T. (Ann. Endocrinol. (Paris) 2000)
    296. MR imaging of the pituitary gland in children and young adults with congenital combined pituitary hormone deficiency associated with PROP1 mutations. (PubMed id 10658742)9 Fofanova O....Yamashita S. (AJR Am J Roentgenol 2000)
    297. Genetic regulation of the embryology of the pituitary gland and somatotrophs. (PubMed id 10905370)9 Cohen L.E. (Endocrine 2000)
    298. Cloning, characterization, and physical mapping of the canine Prop-1 gene (PROP1): exclusion as a candidate for combined pituitary hormone deficiency in German shepherd dogs. (PubMed id 10773688)9 Lantinga-van Leeuwen I.S....van Oost B.A. (Cytogenet. Cell Genet. 2000)
    299. Biochemical and genetic characterization of the porcine Prophet of Pit-1 pituitary transcription factor. (PubMed id 11064154)9 Sloop K.W....Rhodes S.J. (Mol. Cell. Endocrinol. 2000)
    300. Central hypocortisolism as part of combined pituitary hormone deficiency due to mutations of PROP-1 gene. (PubMed id 11022176)9 Asteria C....Beck-Peccoz P. (Eur. J. Endocrinol. 2000)
    301. The Pit-1beta domain dictates active repression and alteration of histone acetylation of the proximal prolactin promoter. (PubMed id 10921928)9 Diamond S.E. and Gutierrez-Hartmann A. (J. Biol. Chem. 2000)
    302. cAMP response element-binding protein-binding protein mediates thyrotropin-releasing hormone signaling on thyrotropin subunit genes. (PubMed id 10931853)9 Hashimoto K....Wondisford F.E. (J. Biol. Chem. 2000)
    303. Functional significance of prop-1 gene expression in pituitary adenomas. (PubMed id 10890192)9 Usui T....Nakao K. (Endocr. J. 2000)
    304. The molecular basis for developmental disorders of the pituitary gland in man. (PubMed id 10852367)9 Dattani M.T. and Robinson I.C. (Clin. Genet. 2000)
    305. Cloning and characterization of the 5'-flanking region of the human prolactin-releasing peptide receptor gene. (PubMed id 11027489)9 Kishimoto M....Chihara K. (Biochem. Biophys. Res. Commun. 2000)
    306. Heritable disorders of pituitary development. (PubMed id 10599689)9 Parks J.S....Wajnrajch M.P. (J. Clin. Endocrinol. Metab. 1999)
    307. Hypopituitarism in two brothers born by breech delivery. (PubMed id 15251687)9 del RincA^n J.P....Mutchinick O. (Endocr Pract 1999)
    308. GH transcription factors. (PubMed id 10698595)9 Pfaffle R.W....Kentrup H. (amp 1999)
    309. A novel mechanism for cyclic adenosine 3',5'-monophosphate regulation of gene expression by CREB-binding protein. (PubMed id 9973256)9 Zanger K....Wondisford F.E. (Mol. Endocrinol. 1999)
    310. Molecular basis of pituitary oncogenesis. (PubMed id 10728913)9 Tada M....Moriuchi T. (J. Neurooncol. 1999)
    311. Gene analysis of PROP1 in dwarfism with combined pituitary hormone deficiency. (PubMed id 10549300)9 Takamura N....Yamashita S. (amp 1999)
    312. Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain. (PubMed id 10369682)9 Tremblay J.J....Drouin J. (EMBO J. 1999)
    313. Human chromosome 3 and pig chromosome 13 show complete synteny conservation but extensive gene-order differences. (PubMed id 10449917)9 Sun H.F....Tuggle C.K. (Cytogenet. Cell Genet. 1999)
    314. Reverse transcription polymerase chain reaction analysis of pituitary hormone, Pit-1 and steroidogenic factor-1 messenger RNA expression in pituitary tumors. (PubMed id 11081157)9 McDermott M.T....Ridgway E.C. (Pituitary 1999)
    315. Quantitative analysis of growth-related factors in human pituitary adenomas. Lowered insulin-like growth factor-I and its receptor mRNA in growth hormone-producing adenomas. (PubMed id 10498342)9 Otsuka F....Makino H. (Regul. Pept. 1999)
    316. DNase I hypersensitivity analysis of non-pituitary human prolactin gene expression. (PubMed id 10432232)9 Gaasenbeek M....DiMattia G.E. (Mol. Cell. Endocrinol. 1999)
    317. Multifunctional role of the Pitx2 homeodomain protein C-terminal tail. (PubMed id 10490637)9 Amendt B.A....Russo A.F. (Mol. Cell. Biol. 1999)
    318. Pituitary hormones as neurotrophic signals: update on hypothalamic differentiation in genetic models of altered feedback. (PubMed id 10510245)9 Phelps C.J. and Hurley D.L. (Proc. Soc. Exp. Biol. Med. 1999)
    319. Free alpha-subunit and intact TSH secretion in vitro are closely associated in human somatotroph adenomas. (PubMed id 9820613)9 Aylwin S.J....Burrin J.M. (Eur. J. Endocrinol. 1998)
    320. Familial growth hormone deficiency associated with MRI abnormalities. (PubMed id 9805128)9 Hamilton J....Daneman D. (Am. J. Med. Genet. 1998)
    321. Phenotypic variability in familial combined pituitary hormone deficiency caused by a PROP1 gene mutation resulting in the substitution of Arg-->Cys at codon 120 (R120C). (PubMed id 9768691)9 Fluck C....Mullis P.E. (J. Clin. Endocrinol. Metab. 1998)
    322. Selective inhibition of prolactin gene transcription by the ETS-2 repressor factor. (PubMed id 9822660)9 Day R.N....Elsholtz H.P. (J. Biol. Chem. 1998)
    323. Compound heterozygous deletion of the PROP-1 gene in children with combined pituitary hormone deficiency. (PubMed id 9661653)9 Fofanova O....Yamashita S. (J. Clin. Endocrinol. Metab. 1998)
    324. How many homeobox genes does it take to make a pituitary gland? (PubMed id 9676531)9 Watkins-Chow D.E. and Camper S.A. (Trends Genet. 1998)
    325. Visualization of Pit-1 transcription factor interactions in the living cell nucleus by fluorescence resonance energy transfer microscopy. (PubMed id 9731708)9 Day R.N. (Mol. Endocrinol. 1998)
    326. Mutations in PROP1 cause familial combined pituitary hormone deficiency. (PubMed id 9462743)9 Wu W.... Rosenfeld M.G. (Nat. Genet. 1998)
    327. Clinical and molecular characterization of a Brazilian patient with Pit-1 deficiency. (PubMed id 9829213)9 Arnhold I.J....Parks J.S. (amp 1998)
    328. A mutational hot spot in the Prop-1 gene in Russian children with combined pituitary hormone deficiency. (PubMed id 11081182)9 Fofanova O.V....Yamashita S. (Pituitary 1998)
    329. [Congenital multiple anterior pituitary hormone deficiencies. An approach of pituitary ontogenesis]. (PubMed id 9686002)9 Brue T....Enjalbert A. (Ann. Endocrinol. (Paris) 1997)
    330. Genomic organization and alternative splicing of human PACE4 (SPC4), kexin-like processing endoprotease. (PubMed id 9378725)9 Tsuji A.... Matsuda Y. (J. Biochem. 1997)
    331. GH and TSH deficiency. (PubMed id 9439906)9 PfAoffle R.W....Heimann G. (amp 1997)
    332. Pituitary homeobox 2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation. (PubMed id 9147650)9 Gage P.J. and Camper S.A. (Hum. Mol. Genet. 1997)
    333. Pituitary stalk interruption syndrome: a clinical-biological-genetic assessment of its pathogenesis. (PubMed id 9329385)9 Pinto G....Brauner R. (J. Clin. Endocrinol. Metab. 1997)
    334. A growth hormone-releasing hormone-producing pancreatic islet cell tumor metastasized to the pituitary is associated with pituitary somatotroph hyperplasia and acromegaly. (PubMed id 9253362)9 Sanno N....Kovacs K. (J. Clin. Endocrinol. Metab. 1997)
    335. Induction of chinook salmon growth hormone promoter activity by the adenosine 3',5'-monophosphate (cAMP)-dependent pathway involves two cAMP-response elements with the CGTCA motif and the pituitary-specific transcription factor Pit-1. (PubMed id 8612514)9 Wong A.O....Hew C.L. (Endocrinology 1996)
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    338. Genetic mapping of the human pituitary-specific transcriptional factor gene and its analysis in familial panhypopituitary dwarfism. (PubMed id 8931705)9 Raskin S....Phillips J.A. (Hum. Genet. 1996)
    339. CCAAT/enhancer-binding protein alpha activation of the rat growth hormone promoter in pituitary progenitor GHFT1-5 cells. (PubMed id 8702932)9 Schaufele F. (J. Biol. Chem. 1996)
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