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Aliases for POTEM Gene

Aliases for POTEM Gene

  • POTE Ankyrin Domain Family, Member M 2 3
  • Prostate-Specific P704P 2 3
  • ANKRD26-Like Family C Member ENSP00000349402 3
  • POTE14beta 3
  • P704P 3
  • ACT 3

External Ids for POTEM Gene

Previous GeneCards Identifiers for POTEM Gene

  • GC02M131218
  • GC14M019984
  • GC14M019987

Summaries for POTEM Gene

GeneCards Summary for POTEM Gene

POTEM (POTE Ankyrin Domain Family, Member M) is a Protein Coding gene. An important paralog of this gene is POTEJ.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POTEM Gene

Genomics for POTEM Gene

Genomic Location for POTEM Gene

18,967,434 bp from pter
19,003,752 bp from pter
36,319 bases
Plus strand

Genomic View for POTEM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for POTEM Gene

No data available for Regulatory Elements for POTEM Gene

Proteins for POTEM Gene

  • Protein details for POTEM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative POTE ankyrin domain family member M
    Protein Accession:

    Protein attributes for POTEM Gene

    508 amino acids
    Molecular mass:
    57067 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POTEM Gene

Proteomics data for POTEM Gene at MOPED

Post-translational modifications for POTEM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POTEM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POTEM Gene

Domains & Families for POTEM Gene

Protein Domains for POTEM Gene

Suggested Antigen Peptide Sequences for POTEM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the POTE family.
  • Contains 5 ANK repeats.
  • Belongs to the POTE family.
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with POTEM: view

Function for POTEM Gene

Gene Ontology (GO) - Molecular Function for POTEM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with POTEM: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for POTEM Gene

Localization for POTEM Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for POTEM Gene

Pathways & Interactions for POTEM Gene

SuperPathways for POTEM Gene

No Data Available

Interacting Proteins for POTEM Gene

Gene Ontology (GO) - Biological Process for POTEM Gene


No data available for Pathways by source and SIGNOR curated interactions for POTEM Gene

Drugs & Compounds for POTEM Gene

(1) Drugs for POTEM Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
serine Nutra 420
genes like me logo Genes that share compounds with POTEM: view

Transcripts for POTEM Gene

mRNA/cDNA for POTEM Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POTEM Gene

POTE ankyrin domain family, member M:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POTEM Gene

No ASD Table

Relevant External Links for POTEM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POTEM Gene

mRNA expression in normal human tissues for POTEM Gene

mRNA differential expression in normal tissues according to GTEx for POTEM Gene

This gene is overexpressed in Prostate (x34.6) and Testis (x17.4).

Protein differential expression in normal tissues from HIPED for POTEM Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for POTEM Gene

SOURCE GeneReport for Unigene cluster for POTEM Gene Hs.654289

genes like me logo Genes that share expression patterns with POTEM: view

Protein tissue co-expression partners for POTEM Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for POTEM Gene

Orthologs for POTEM Gene

This gene was present in the common ancestor of chordates.

Orthologs for POTEM Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
(Canis familiaris)
Mammalia -- 36
  • 6 (a)
-- 36
  • 37 (a)
-- 36
  • 11 (a)
-- 36
  • 6 (a)
-- 36
  • 2 (a)
-- 36
-- 36
  • 36 (a)
-- 36
  • 41 (a)
(Mus musculus)
Mammalia Gm1758 36
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 4 (a)
(Pan troglodytes)
Mammalia -- 36
  • 80 (a)
-- 36
  • 83 (a)
(Gallus gallus)
Aves -- 36
  • 8 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
(Danio rerio)
Actinopterygii ANKRD7 36
  • 5 (a)
Species with no ortholog for POTEM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POTEM Gene

Gene Tree for POTEM (if available)
Gene Tree for POTEM (if available)

Paralogs for POTEM Gene

genes like me logo Genes that share paralogs with POTEM: view

Variants for POTEM Gene

Sequence variations from dbSNP and Humsavar for POTEM Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1988211 -- 18,989,056(-) TACTC(C/T)GTTAT intron-variant
rs2010690 -- 18,987,741(+) CCTTT(A/G)AGCAT intron-variant
rs2226489 -- 18,986,416(-) GCAGT(C/T)GGGTT intron-variant
rs2465716 -- 18,986,183(-) GTTAC(A/C)TTCTT intron-variant
rs2716344 -- 18,986,234(-) TGTTA(C/T)ATTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POTEM Gene

Variant ID Type Subtype PubMed ID
esv23873 CNV Gain+Loss 19812545
esv33527 CNV Gain+Loss 17666407
nsv819711 CNV Loss 19587683
nsv9117 CNV Gain+Loss 18304495
nsv7248 OTHER Inversion 18451855
esv1005804 OTHER Inversion 20482838
dgv45e180 CNV Loss 20482838
nsv901117 CNV Gain 21882294
dgv598e1 CNV Complex 17122850
dgv599e1 CNV Complex 17122850
nsv428292 CNV Gain+Loss 18775914
nsv433422 CNV Gain 18776910
dgv1811n71 CNV Gain 21882294
esv2748433 CNV Deletion 23290073
nsv436829 CNV Insertion 17901297
dgv1812n71 CNV Gain 21882294
dgv600e1 CNV Complex 17122850
dgv601e1 CNV Complex 17122850
dgv1813n71 CNV Gain 21882294
dgv1814n71 CNV Gain 21882294
nsv509526 CNV Insertion 20534489
nsv832732 CNV Loss 17160897
nsv901136 CNV Gain 21882294
dgv1815n71 CNV Loss 21882294
nsv901138 CNV Gain 21882294
nsv901139 CNV Loss 21882294
dgv1816n71 CNV Gain 21882294
dgv1817n71 CNV Loss 21882294

Variation tolerance for POTEM Gene

Gene Damage Index Score: 7.41; 81.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POTEM Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POTEM Gene

Disorders for POTEM Gene

Relevant External Links for POTEM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with POTEM: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POTEM Gene

Publications for POTEM Gene

  1. Prostate-specific antigen stimulates osteoprotegerin production and inhibits receptor activator of nuclear factor-kappaB ligand expression by human osteoblasts. (PMID: 17394194) Yonou H. … Tachibana M. (Prostate 2007) 23 67
  2. Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (PMID: 16364570) Hahn Y. … Lee B. (Gene 2006) 2 67
  3. Sensitive and specific immunodetection of human glandular kallikrein 2 in serum. (PMID: 10657376) Becker C. … Pettersson K. (Clin. Chem. 2000) 23 67
  4. Physicochemical conditions affecting the formation/stability of serum complexes and the determination of prostate-specific antigen (PSA). (PMID: 10652627) Kioukia-Fougia N. … Strantzalis N. (Anticancer Res. 1999) 23 67
  5. Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1. (PMID: 10209959) Mikolajczyk S.D. … Saedi M.S. (Int. J. Cancer 1999) 23 67

Products for POTEM Gene

Sources for POTEM Gene

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