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POTEM Gene

protein-coding   GIFtS: 36
GCID: GC14M019987

POTE Ankyrin Domain Family, Member M

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
POTE Ankyrin Domain Family, Member M1 2     POTE14beta2
Prostate-Specific P704P1 2     ANKRD26-Like Family C Member ENSP000003494022
ACT2     Putative POTE Ankyrin Domain Family Member M2
P704P2     

External Ids:    HGNC: 370961   Entrez Gene: 6414552   Ensembl: ENSG000001875377   UniProtKB: A6NI473   

Export aliases for POTEM gene to outside databases

Previous GC identifers: GC02M131218 GC14M019984


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for POTEM Gene:
POTEM (POTE ankyrin domain family, member M) is a protein-coding gene. An important paralog of this gene is POTEF.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for POTEM
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for POTEM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POTEM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

POTEM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POTEM gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M019987:  view genomic region     (about GC identifiers)

Start:
19,983,559 bp from pter      End:
20,020,272 bp from pter
Size:
36,714 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: POTEM_HUMAN, A6NI47 (See protein sequence)
Recommended Name: Putative POTE ankyrin domain family member M  
Size: 508 amino acids; 57067 Da

Explore the universe of human proteins at neXtProt for POTEM: NX_A6NI47

Explore proteomics data for POTEM at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POTEM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001138914.1  
    ENSEMBL proteins: 
     ENSP00000452296   ENSP00000450853   ENSP00000450807  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POTE: POTE ankyrin domain containing
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry A6NI47

    ProtoNet protein and cluster: A6NI47

    UniProtKB/Swiss-Prot: POTEM_HUMAN, A6NI47
    Similarity: Belongs to the POTE family
    Similarity: Contains 5 ANK repeats


    Find genes that share domains with POTEM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with POTEM           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for POTEM

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    hsa-miR-433 hsa-miR-98 hsa-miR-875-3p hsa-miR-1237 hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-371-5p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POTEM About    
    See pathways by source

    SuperPathContained pathways About
    1Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    2Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POTEM
    Interactions:

        Search GeneGlobe Interaction Network for POTEM

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POTEM

    1 Novoseek inferred chemical compound relationship for POTEM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 28.2 1 17394194 (1)



    Find genes that share compounds with POTEM           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POTEM gene: 
    NM_001145442.1  

    Unigene Cluster for POTEM:

    POTE ankyrin domain family, member M
    Hs.654289  [show with all ESTs]
    Unigene Representative Sequence: NM_001145442
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000551509(uc001vwc.3 uc001vwb.3) ENST00000547848 ENST00000547722

    miRNA
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    hsa-miR-433 hsa-miR-98 hsa-miR-875-3p hsa-miR-1237 hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-371-5p
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    Additional mRNA sequence: 

    AY338952.1 HM358945.1 HM358955.1 HM358968.1 HM358973.1 HM358979.1 HM358983.1 HM358995.1 

    3 DOTS entries:

    DT.100015986  DT.120764792  DT.121089732 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    POTEM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    POTEM Expression
    About this image

    POTEM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POTEM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654289
        Custom PCR Arrays for POTEM
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POTEM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for POTEM gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    8(a)
    1 → many
    1(24064036-24111623)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    36(a)
    many ↔ many
    GL344195.1(38786-58936)
    zebrafish
    (Danio rerio)
    Actinopterygii ANKRD76
    ankyrin repeat domain 7
    5(a)
    1 → many
    25(3581527-3655709) ENSDARG00000013015
            Species with no ortholog for POTEM

    ENSEMBL Gene Tree for POTEM (if available)
    TreeFam Gene Tree for POTEM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POTEM gene
    POTEG1 2  POTEH1 2  POTEF2  POTEI2  ANKRD30A2  POTEB22  ANKRD362  ANKRD72  
    POTEB2  ANKRD30BL2  ANKRD20A32  ANKRD30B2  LOC6442492  ENSG000002663022  ANKRD36C2  POTEJ2  
    POTEC2  ANKRD20A22  ANKRD262  ANKRD622  ANKRD18A2  ANKRD20A12  CCDC144A2  POTED2  
    POTEE2  ANKRD20A42  ANKRD18B2  LOC1002889662  
    Selected SIMAP similar genes for POTEM using alignment to 4 protein entries:     POTEM_HUMAN (see all proteins) (see all similar genes):
    POTEG    POTEKP    PS1TP5BP1    ACT    ACTB    ACTC1
    ACTA2    POTEC    POTEH    POTEF    POTED    ACTG1
    ACTBL2    POTEI    POTEE    ACTG2    POTEA    POTEB

    Find genes that share paralogs with POTEM           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POTEM (see all 189)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440009991,2
    --19983490(+) TTTTG-/TTTTTT 1 -- ds50010--------
    rs1420462511,2
    --19983497(+) TTTTTG/TGGGGG 1 -- ds50010--------
    rs1927250901,2
    C--19983536(+) TGTTTC/TTGTTT 1 -- ds50010--------
    rs1843429351,2
    C--19983574(+) TATATA/TTTTTT 1 -- ds50010--------
    rs2003981151,2
    C--19983596(+) TTTTTG/TGCAGC 1 -- ds50010--------
    rs2014539061,2
    C--19983941(+) AAACTC/TACACT 1 -- ds50010--------
    rs801502841,2
    F--19988227(+) TGCTCG/TGCCAT 1 -- ut311Minor allele frequency- T:0.50NA 4
    rs755970801,2
    C--19988246(+) AACTAC/TAGCCA 1 -- ut310--------
    rs2001172391,2
    F--19988271(+) CTTCAT/GGAGGT 1 -- ut311Minor allele frequency- G:0.01EU 407
    rs2008998901,2
    F--19988279(+) GGTAGT/CCAGTC 1 -- ut311Minor allele frequency- C:0.28EU 189

    HapMap Linkage Disequilibrium report for POTEM (19983559 - 20020272 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for POTEM (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748433CNV Deletion23290073
    nsv436829CNV Insertion17901297
    nsv509526CNV Insertion20534489
    dgv1817n71CNV Loss21882294
    nsv819711CNV Loss19587683
    dgv1815n71CNV Loss21882294
    nsv901139CNV Loss21882294
    nsv832732CNV Loss17160897
    dgv45e180CNV Loss20482838
    dgv1816n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing POTEM
    DNA2.0 Custom Variant and Variant Library Synthesis for POTEM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with POTEM           About GenesLikeMe

    2 Novoseek inferred disease relationships for POTEM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 56.5 3 10652627 (1), 9610595 (1), 10174623 (1)
    cancer 8.17 1 10174623 (1)


    Export disorders for POTEM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POTEM gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with POTEM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (PubMed id 16364570)1, 3 Hahn Y.... Lee B. (Gene 2006)
    2. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. Identification of a novel actin isoform in hepatocellular carcinoma. (PubMed id 16824795)1 Chang K.-W.... Yeh C.-T. (Hepatol. Res. 2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Physicochemical conditions affecting the formation/stability of serum complexes and the determination of prostate-specific antigen (PSA). (PubMed id 10652627)9 Kioukia-Fougia N....Strantzalis N. (Anticancer Res. 1999)
    9. Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1. (PubMed id 10209959)9 Mikolajczyk S.D....Saedi M.S. (Int. J. Cancer 1999)
    10. Sensitive and specific immunodetection of human glandular kallikrein 2 in serum. (PubMed id 10657376)9 Becker C....Pettersson K. (Clin. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 641455 HGNC: 37096 Ensembl:ENSG00000187537 euGenes: HUgn641455 ECgene: POTEM
    H-InvDB: POTEM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POTEM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POTEM gene:
    Search GeneIP for patents involving POTEM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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