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Aliases for POTEM Gene

Aliases for POTEM Gene

  • POTE Ankyrin Domain Family Member M 2 3 5
  • Prostate-Specific P704P 2 3
  • ANKRD26-Like Family C Member ENSP00000349402 3
  • Putative POTE Ankyrin Domain Family Member M 3
  • POTE Ankyrin Domain Family, Member M 2
  • POTE14beta 3
  • P704P 3
  • ACT 3

External Ids for POTEM Gene

Previous GeneCards Identifiers for POTEM Gene

  • GC02M131218
  • GC14M019984
  • GC14M019987

Summaries for POTEM Gene

GeneCards Summary for POTEM Gene

POTEM (POTE Ankyrin Domain Family Member M) is a Protein Coding gene. An important paralog of this gene is POTEG.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POTEM Gene

Genomics for POTEM Gene

Genomic Location for POTEM Gene

18,967,434 bp from pter
19,003,752 bp from pter
36,319 bases
Plus strand

Genomic View for POTEM Gene

Genes around POTEM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POTEM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POTEM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTEM Gene

No data available for Regulatory Elements for POTEM Gene

Proteins for POTEM Gene

  • Protein details for POTEM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative POTE ankyrin domain family member M
    Protein Accession:

    Protein attributes for POTEM Gene

    508 amino acids
    Molecular mass:
    57067 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POTEM Gene

Post-translational modifications for POTEM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POTEM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POTEM Gene

Domains & Families for POTEM Gene

Protein Domains for POTEM Gene

Suggested Antigen Peptide Sequences for POTEM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the POTE family.
  • Belongs to the POTE family.
genes like me logo Genes that share domains with POTEM: view

Function for POTEM Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POTEM Gene

Localization for POTEM Gene

Gene Ontology (GO) - Cellular Components for POTEM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with POTEM: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for POTEM Gene

Pathways & Interactions for POTEM Gene

SuperPathways for POTEM Gene

No Data Available

Interacting Proteins for POTEM Gene

Gene Ontology (GO) - Biological Process for POTEM Gene


No data available for Pathways by source and SIGNOR curated interactions for POTEM Gene

Drugs & Compounds for POTEM Gene

(1) Drugs for POTEM Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with POTEM: view

Transcripts for POTEM Gene

mRNA/cDNA for POTEM Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POTEM Gene

POTE ankyrin domain family, member M:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POTEM Gene

No ASD Table

Relevant External Links for POTEM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POTEM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POTEM Gene

mRNA differential expression in normal tissues according to GTEx for POTEM Gene

This gene is overexpressed in Prostate (x34.6) and Testis (x17.4).

Protein differential expression in normal tissues from HIPED for POTEM Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for POTEM Gene

Protein tissue co-expression partners for POTEM Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POTEM Gene:


SOURCE GeneReport for Unigene cluster for POTEM Gene:


Evidence on tissue expression from TISSUES for POTEM Gene

  • Lung(2.9)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with POTEM: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POTEM Gene

Orthologs for POTEM Gene

This gene was present in the common ancestor of chordates.

Orthologs for POTEM Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 83 (a)
-- 35
  • 80 (a)
(Canis familiaris)
Mammalia -- 35
  • 41 (a)
-- 35
  • 37 (a)
-- 35
  • 36 (a)
-- 35
  • 11 (a)
-- 35
  • 6 (a)
-- 35
  • 6 (a)
-- 35
  • 2 (a)
-- 35
(Mus musculus)
Mammalia Gm1758 35
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 4 (a)
(Bos Taurus)
Mammalia -- 35
(Gallus gallus)
Aves -- 35
  • 8 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
(Danio rerio)
Actinopterygii ANKRD7 35
  • 5 (a)
Species where no ortholog for POTEM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POTEM Gene

Gene Tree for POTEM (if available)
Gene Tree for POTEM (if available)

Paralogs for POTEM Gene

genes like me logo Genes that share paralogs with POTEM: view

Variants for POTEM Gene

Sequence variations from dbSNP and Humsavar for POTEM Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000544170 -- 18,974,287(-) AGTAC(A/G)ATAGA intron-variant
rs1000638852 -- 18,980,939(-) GCAGA(A/G)CATCT intron-variant, upstream-variant-2KB
rs1001874385 -- 18,990,905(-) CTTCA(C/T)CTTAA intron-variant
rs1002367911 -- 19,000,292(-) GCTTT(C/T)AGAAG utr-variant-3-prime
rs1004196550 -- 18,972,101(-) AATGG(G/T)GCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POTEM Gene

Variant ID Type Subtype PubMed ID
dgv1151e59 CNV duplication 20981092
dgv1152e59 CNV duplication 20981092
dgv1153e59 CNV duplication 20981092
dgv1154e59 CNV duplication 20981092
dgv1155e59 CNV duplication 20981092
dgv1749n100 CNV gain 25217958
dgv1750n100 CNV gain+loss 25217958
dgv1751n100 CNV loss 25217958
dgv1752n100 CNV gain 25217958
dgv1753n100 CNV gain 25217958
dgv1754n100 CNV gain+loss 25217958
dgv1755n100 CNV gain 25217958
dgv1756n100 CNV loss 25217958
dgv1757n100 CNV gain 25217958
dgv1758n100 CNV loss 25217958
dgv1759n100 CNV gain 25217958
dgv1760n100 CNV gain+loss 25217958
dgv1761n100 CNV gain+loss 25217958
dgv1762n100 CNV loss 25217958
dgv1763n100 CNV gain 25217958
dgv1764n100 CNV loss 25217958
dgv1765n100 CNV gain+loss 25217958
dgv1766n100 CNV gain 25217958
dgv33e203 CNV gain+loss 21179565
dgv3489n54 CNV gain 21841781
dgv3494n54 CNV loss 21841781
dgv3496n54 CNV gain 21841781
dgv3497n54 CNV gain 21841781
dgv360n67 CNV gain 20364138
dgv45e180 CNV loss 20482838
esv1005804 OTHER inversion 20482838
esv23873 CNV gain+loss 19812545
esv3332769 CNV duplication 20981092
esv3335947 CNV duplication 20981092
esv3344617 CNV duplication 20981092
esv33527 CNV gain+loss 17666407
esv3409251 CNV duplication 20981092
esv3431423 CNV duplication 20981092
esv3446376 CNV duplication 20981092
esv3892461 CNV gain 25118596
nsv1037353 CNV gain 25217958
nsv1048150 CNV gain+loss 25217958
nsv1048393 CNV gain+loss 25217958
nsv1076404 CNV duplication 25765185
nsv1078362 CNV duplication 25765185
nsv1110230 CNV duplication 24896259
nsv1110231 CNV duplication 24896259
nsv1110856 OTHER inversion 24896259
nsv1115453 CNV duplication 24896259
nsv1115454 CNV duplication 24896259
nsv1128690 CNV duplication 24896259
nsv1133205 CNV tandem duplication 24896259
nsv1139593 CNV duplication 24896259
nsv1150751 CNV duplication 26484159
nsv1160151 CNV duplication 26073780
nsv471368 CNV gain 19718026
nsv514725 CNV gain 21397061
nsv514726 CNV gain 21397061
nsv563641 CNV gain 21841781
nsv563699 CNV loss 21841781
nsv563700 CNV gain 21841781
nsv563701 CNV loss 21841781
nsv563702 CNV gain 21841781
nsv563703 CNV loss 21841781
nsv563704 CNV gain 21841781
nsv563705 CNV loss 21841781
nsv7248 OTHER inversion 18451855
nsv819711 CNV loss 19587683
nsv832729 CNV gain+loss 17160897
nsv9117 CNV gain+loss 18304495
nsv951949 CNV duplication 24416366
nsv974391 CNV duplication 23825009
nsv977527 CNV duplication 23825009
nsv977528 CNV duplication 23825009
nsv983792 CNV duplication 23825009

Variation tolerance for POTEM Gene

Gene Damage Index Score: 7.41; 81.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POTEM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POTEM Gene

Disorders for POTEM Gene

Relevant External Links for POTEM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for POTEM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POTEM Gene

Publications for POTEM Gene

  1. Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (PMID: 16364570) Hahn Y. … Lee B. (Gene 2006) 2 3 64
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 64
  3. Prostate-specific antigen stimulates osteoprotegerin production and inhibits receptor activator of nuclear factor-kappaB ligand expression by human osteoblasts. (PMID: 17394194) Yonou H. … Tachibana M. (Prostate 2007) 22 64
  4. Identification of a novel actin isoform in hepatocellular carcinoma. (PMID: 16824795) Chang K.-W. … Yeh C.-T. (Hepatol. Res. 2006) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for POTEM Gene

Sources for POTEM Gene

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