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Aliases for POTEKP Gene

Aliases for POTEKP Gene

  • POTE Ankyrin Domain Family Member K, Pseudogene 2 3 5
  • Actin, Beta-Like 3 2 3
  • Kappa-Actin 3 4
  • ACTBL3 3 4
  • POTE Ankyrin Domain Family, Member K, Pseudogene 2
  • POTE Ankyrin Domain Family, Member K 2
  • POTE Ankyrin Domain Family Member K 4
  • Beta-Actin-Like Protein 3 3
  • Actin-Like Protein 3
  • POTE2delta 3
  • POTEK 3
  • ACT 3

External Ids for POTEKP Gene

Previous HGNC Symbols for POTEKP Gene

  • ACTBL3
  • POTEK

Previous GeneCards Identifiers for POTEKP Gene

  • GC02P132069
  • GC02P132350
  • GC02P124342

Summaries for POTEKP Gene

GeneCards Summary for POTEKP Gene

POTEKP (POTE Ankyrin Domain Family Member K, Pseudogene) is a Pseudogene. Among its related pathways are Response to elevated platelet cytosolic Ca2+.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POTEKP Gene

Genomics for POTEKP Gene

Genomic Location for POTEKP Gene

Chromosome:
2
Start:
131,591,752 bp from pter
End:
131,627,266 bp from pter
Size:
35,515 bases
Orientation:
Plus strand

Genomic View for POTEKP Gene

Genes around POTEKP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POTEKP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POTEKP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTEKP Gene

No data available for Regulatory Elements for POTEKP Gene

Proteins for POTEKP Gene

  • Protein details for POTEKP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYX7-ACTBM_HUMAN
    Recommended name:
    Putative beta-actin-like protein 3
    Protein Accession:
    Q9BYX7
    Secondary Accessions:
    • Q562N5

    Protein attributes for POTEKP Gene

    Size:
    375 amino acids
    Molecular mass:
    42016 Da
    Quaternary structure:
    • Interacts with PFN1 and PFDN1. Does not interact with PFN2.

neXtProt entry for POTEKP Gene

Post-translational modifications for POTEKP Gene

  • Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
  • Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for POTEKP Gene

Domains & Families for POTEKP Gene

Gene Families for POTEKP Gene

Protein Domains for POTEKP Gene

Suggested Antigen Peptide Sequences for POTEKP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYX7

UniProtKB/Swiss-Prot:

ACTBM_HUMAN :
  • Belongs to the actin family.
Family:
  • Belongs to the actin family.
genes like me logo Genes that share domains with POTEKP: view

Function for POTEKP Gene

Gene Ontology (GO) - Molecular Function for POTEKP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with POTEKP: view

Phenotypes for POTEKP Gene

GenomeRNAi human phenotypes for POTEKP:
genes like me logo Genes that share phenotypes with POTEKP: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POTEKP Gene

Localization for POTEKP Gene

Subcellular locations from UniProtKB/Swiss-Prot for POTEKP Gene

Cytoplasm, cytoskeleton.

Gene Ontology (GO) - Cellular Components for POTEKP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with POTEKP: view

No data available for Subcellular locations from COMPARTMENTS for POTEKP Gene

Pathways & Interactions for POTEKP Gene

genes like me logo Genes that share pathways with POTEKP: view

Interacting Proteins for POTEKP Gene

Selected Interacting proteins: Q9BYX7-ACTBM_HUMAN for POTEKP Gene via IID

Gene Ontology (GO) - Biological Process for POTEKP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
genes like me logo Genes that share ontologies with POTEKP: view

No data available for SIGNOR curated interactions for POTEKP Gene

Drugs & Compounds for POTEKP Gene

No Compound Related Data Available

Transcripts for POTEKP Gene

mRNA/cDNA for POTEKP Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POTEKP Gene

POTE ankyrin domain family, member K, pseudogene:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POTEKP Gene

No ASD Table

Relevant External Links for POTEKP Gene

GeneLoc Exon Structure for
POTEKP
ECgene alternative splicing isoforms for
POTEKP

Expression for POTEKP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POTEKP Gene

mRNA differential expression in normal tissues according to GTEx for POTEKP Gene

This gene is overexpressed in Testis (x29.5) and Breast - Mammary Tissue (x16.3).

Protein differential expression in normal tissues from HIPED for POTEKP Gene

This gene is overexpressed in Urinary Bladder (48.4) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for POTEKP Gene



Protein tissue co-expression partners for POTEKP Gene

NURSA nuclear receptor signaling pathways regulating expression of POTEKP Gene:

POTEKP

SOURCE GeneReport for Unigene cluster for POTEKP Gene:

Hs.631267

mRNA Expression by UniProt/SwissProt for POTEKP Gene:

Q9BYX7-ACTBM_HUMAN
Tissue specificity: Expressed in some hepatocellular carcinomas.
genes like me logo Genes that share expression patterns with POTEKP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for POTEKP Gene

Orthologs for POTEKP Gene

Evolution for POTEKP Gene

ENSEMBL:
Gene Tree for POTEKP (if available)
TreeFam:
Gene Tree for POTEKP (if available)

No data available for Orthologs for POTEKP Gene

Paralogs for POTEKP Gene

genes like me logo Genes that share paralogs with POTEKP: view

No data available for Paralogs for POTEKP Gene

Variants for POTEKP Gene

Sequence variations from dbSNP and Humsavar for POTEKP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000002212 -- 131,599,845(+) AGGAG(A/C)AGCGT intron-variant
rs1000155224 -- 131,601,685(+) AGTTA(C/G)TCCCT intron-variant
rs1000221579 -- 131,599,654(+) TAGAG(A/T)CAAAA intron-variant
rs1000321531 -- 131,599,414(+) TGTTA(A/G)TTTAG intron-variant
rs1000352250 -- 131,608,742(+) CCATC(C/T)TGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POTEKP Gene

Variant ID Type Subtype PubMed ID
esv2670824 CNV deletion 23128226
esv2759092 CNV gain+loss 17122850
esv2762850 CNV gain 21179565
esv34704 CNV gain 17911159
esv3592488 CNV gain 21293372
esv3592489 CNV gain 21293372
nsv1004760 CNV gain 25217958
nsv1011967 CNV gain 25217958
nsv1014682 CNV loss 25217958
nsv10186 CNV loss 18304495
nsv428404 CNV loss 18775914
nsv483103 CNV gain+loss 15286789
nsv820012 CNV loss 19587683
nsv961887 CNV duplication 23825009
nsv962008 CNV duplication 23825009
nsv962009 CNV duplication 23825009
nsv979268 CNV duplication 23825009
nsv997248 CNV loss 25217958

Relevant External Links for POTEKP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POTEKP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for POTEKP Gene

Disorders for POTEKP Gene

Relevant External Links for POTEKP

Genetic Association Database (GAD)
POTEKP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POTEKP

No disorders were found for POTEKP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POTEKP Gene

Publications for POTEKP Gene

  1. Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (PMID: 16364570) Hahn Y. … Lee B. (Gene 2006) 2 3 64
  2. Identification of a novel actin isoform in hepatocellular carcinoma. (PMID: 16824795) Chang K.-W. … Yeh C.-T. (Hepatol. Res. 2006) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64

Products for POTEKP Gene

Sources for POTEKP Gene

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