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Aliases for POTEKP Gene

Aliases for POTEKP Gene

  • POTE Ankyrin Domain Family, Member K, Pseudogene 2 3
  • ACTBL3 3 4 6
  • POTE Ankyrin Domain Family Member K 3 4
  • Actin, Beta-Like 3 2 3
  • Kappa-Actin 3 4
  • POTEK 3 6
  • ACT 3 6
  • POTE Ankyrin Domain Family, Member K 2
  • Beta-Actin-Like Protein 3 3
  • Actin-Like Protein 3
  • POTE2delta 3
  • FKSG30 6

External Ids for POTEKP Gene

Previous HGNC Symbols for POTEKP Gene

  • ACTBL3
  • POTEK

Previous GeneCards Identifiers for POTEKP Gene

  • GC02P132069
  • GC02P132350
  • GC02P124342

Summaries for POTEKP Gene

GeneCards Summary for POTEKP Gene

POTEKP (POTE Ankyrin Domain Family, Member K, Pseudogene) is a Pseudogene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POTEKP Gene

Genomics for POTEKP Gene

Genomic Location for POTEKP Gene

Start:
131,591,752 bp from pter
End:
131,627,266 bp from pter
Size:
35,515 bases
Orientation:
Plus strand

Genomic View for POTEKP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POTEKP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTEKP Gene

No data available for Regulatory Elements for POTEKP Gene

Proteins for POTEKP Gene

  • Protein details for POTEKP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYX7-ACTBM_HUMAN
    Recommended name:
    Putative beta-actin-like protein 3
    Protein Accession:
    Q9BYX7
    Secondary Accessions:
    • Q562N5

    Protein attributes for POTEKP Gene

    Size:
    375 amino acids
    Molecular mass:
    42016 Da
    Quaternary structure:
    • Interacts with PFN1 and PFDN1. Does not interact with PFN2.

neXtProt entry for POTEKP Gene

Proteomics data for POTEKP Gene at MOPED

Post-translational modifications for POTEKP Gene

  • Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration
  • Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POTEKP Gene

Reactome Protein details:

No data available for DME Specific Peptides for POTEKP Gene

Domains for POTEKP Gene

Gene Families for POTEKP Gene

HGNC:
  • POTE :POTE ankyrin domain containing

Protein Domains for POTEKP Gene

Suggested Antigen Peptide Sequences for POTEKP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYX7

UniProtKB/Swiss-Prot:

ACTBM_HUMAN :
  • Q9BYX7
Family:
  • Belongs to the actin family.
genes like me logo Genes that share domains with POTEKP: view

Function for POTEKP Gene

Gene Ontology (GO) - Molecular Function for POTEKP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with POTEKP: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for POTEKP Gene

Localization for POTEKP Gene

Subcellular locations from UniProtKB/Swiss-Prot for POTEKP Gene

Cytoplasm, cytoskeleton.

Gene Ontology (GO) - Cellular Components for POTEKP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with POTEKP: view

No data available for Subcellular locations from COMPARTMENTS for POTEKP Gene

Pathways for POTEKP Gene

SuperPathways for POTEKP Gene

No Data Available

Interacting Proteins for POTEKP Gene

Selected Interacting proteins: Q9BYX7-ACTBM_HUMAN for POTEKP Gene via MINT I2D

Gene Ontology (GO) - Biological Process for POTEKP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0007596 blood coagulation TAS --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with POTEKP: view

No data available for Pathways by source for POTEKP Gene

Transcripts for POTEKP Gene

mRNA/cDNA for POTEKP Gene

(9) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POTEKP Gene

POTE ankyrin domain family, member K, pseudogene:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POTEKP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for POTEKP
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POTEKP Gene

No ASD Table

Relevant External Links for POTEKP Gene

GeneLoc Exon Structure for
POTEKP
ECgene alternative splicing isoforms for
POTEKP

Expression for POTEKP Gene

mRNA expression in normal human tissues for POTEKP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for POTEKP Gene

This gene is overexpressed in Testis (29.5) and Breast - Mammary Tissue (16.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for POTEKP Gene

SOURCE GeneReport for Unigene cluster for POTEKP Gene Hs.631267

mRNA Expression by UniProt/SwissProt for POTEKP Gene

Q9BYX7-ACTBM_HUMAN
Tissue specificity: Expressed in some hepatocellular carcinomas.
genes like me logo Genes that share expressions with POTEKP: view

In Situ Assay Products

Orthologs for POTEKP Gene

Evolution for POTEKP Gene

ENSEMBL:
Gene Tree for POTEKP (if available)
TreeFam:
Gene Tree for POTEKP (if available)

No data available for Orthologs for POTEKP Gene

Paralogs for POTEKP Gene

genes like me logo Genes that share paralogs with POTEKP: view

No data available for Paralogs for POTEKP Gene

Variants for POTEKP Gene

Sequence variations from dbSNP and Humsavar for POTEKP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1509580 -- 131,608,864(-) CCTCC(A/G)ACTCC intron-variant
rs1818396 -- 131,603,018(-) TCTTA(C/T)ATGAC intron-variant
rs1848717 -- 131,599,901(-) CATAG(A/G)AAGTA intron-variant
rs1979997 -- 131,609,421(-) TAAGC(C/T)TTTGT downstream-variant-500B
rs1979998 -- 131,609,350(-) AAAAT(A/C)AACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POTEKP Gene

Variant ID Type Subtype PubMed ID
dgv1247e1 CNV Complex 17122850
esv2670824 CNV Deletion 23128226
dgv1252e1 CNV Complex 17122850
dgv1254e1 CNV Complex 17122850
nsv428404 CNV Loss 18775914
dgv1256e1 CNV Complex 17122850
dgv4313n71 CNV Gain 21882294
nsv875115 CNV Gain 21882294
esv34704 CNV Gain 17911159
essv2396 CNV CNV 17122850
dgv1257e1 CNV Complex 17122850
essv1836 CNV CNV 17122850
dgv4314n71 CNV Gain 21882294
dgv1258e1 CNV Complex 17122850
nsv834376 CNV Gain 17160897
dgv1259e1 CNV Complex 17122850
dgv1260e1 CNV Complex 17122850
nsv483103 CNV Complex 15286789
nsv10186 CNV Loss 18304495
essv4317 CNV CNV 17122850
essv19805 CNV CNV 17122850
nsv820012 CNV Loss 19587683
nsv834377 CNV Gain 17160897
esv2720787 CNV Deletion 23290073
esv2660323 CNV Deletion 23128226

Relevant External Links for POTEKP Gene

HapMap Linkage Disequilibrium report
POTEKP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POTEKP Gene

Disorders for POTEKP Gene

Relevant External Links for POTEKP

Genetic Association Database (GAD)
POTEKP
genes like me logo Genes that share disorders with POTEKP: view

No data available for UniProtKB/Swiss-Prot for POTEKP Gene

Publications for POTEKP Gene

  1. Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (PMID: 16364570) Hahn Y. … Lee B. (Gene 2006) 2 3
  2. Identification of a novel actin isoform in hepatocellular carcinoma. (PMID: 16824795) Chang K.-W. … Yeh C.-T. (Hepatol. Res. 2006) 3 4
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Highly efficient purification of protein complexes from mammalian cells using a novel streptavidin-binding peptide and hexahistidine tandem tag system: application to Bruton's tyrosine kinase. (PMID: 21080425) Li Y. … Vondriska T.M. (Protein Sci. 2011) 3
  5. The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PMID: 21800051) Fang Y. … Shen X. (Mol. Cell. Biochem. 2012) 3

Products for POTEKP Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate POTEKP
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for POTEKP
    • Block miRNA regulation of POTEKP using miScript Target Protectors

    Sources for POTEKP Gene

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