Free for academic non-profit institutions. Other users need a Commercial license

Aliases for POTEH Gene

Aliases for POTEH Gene

  • POTE Ankyrin Domain Family Member H 2 3 5
  • Prostate, Ovary, Testis-Expressed Protein On Chromosome 22 3 4
  • Cancer/Testis Antigen Family 104, Member 7 2 3
  • ANKRD26-Like Family C Member 3 3 4
  • Actin, Beta-Like 1 2 3
  • ACTBL1 3 4
  • POTE22 3 4
  • A26C3 3 4
  • Protein Expressed In Prostate, Ovary, Testis, And Placenta POTE14 Like 3
  • Protein Expressed In Prostate, Ovary, Testis, And Placenta 22 3
  • POTE Ankyrin Domain Family, Member H 2
  • ANKRD26-Like Family C, Member 3 2
  • CT104.7 3
  • POTE-22 4

External Ids for POTEH Gene

Previous HGNC Symbols for POTEH Gene

  • ACTBL1
  • A26C3

Previous GeneCards Identifiers for POTEH Gene

  • GC22M014640
  • GC22M016256

Summaries for POTEH Gene

GeneCards Summary for POTEH Gene

POTEH (POTE Ankyrin Domain Family Member H) is a Protein Coding gene. An important paralog of this gene is POTEM.

Additional gene information for POTEH Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POTEH Gene

Genomics for POTEH Gene

Genomic Location for POTEH Gene

Chromosome:
22
Start:
15,690,026 bp from pter
End:
15,721,631 bp from pter
Size:
31,606 bases
Orientation:
Plus strand

Genomic View for POTEH Gene

Genes around POTEH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POTEH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POTEH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTEH Gene

Proteins for POTEH Gene

  • Protein details for POTEH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6S545-POTEH_HUMAN
    Recommended name:
    POTE ankyrin domain family member H
    Protein Accession:
    Q6S545
    Secondary Accessions:
    • A2CEK4
    • A6NCI1
    • A9Z1W0

    Protein attributes for POTEH Gene

    Size:
    545 amino acids
    Molecular mass:
    60965 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for POTEH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POTEH Gene

Post-translational modifications for POTEH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POTEH Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POTEH Gene

Domains & Families for POTEH Gene

Gene Families for POTEH Gene

Protein Domains for POTEH Gene

Suggested Antigen Peptide Sequences for POTEH Gene

Graphical View of Domain Structure for InterPro Entry

Q6S545

UniProtKB/Swiss-Prot:

POTEH_HUMAN :
  • Belongs to the POTE family.
Family:
  • Belongs to the POTE family.
genes like me logo Genes that share domains with POTEH: view

Function for POTEH Gene

Phenotypes for POTEH Gene

GenomeRNAi human phenotypes for POTEH:
genes like me logo Genes that share phenotypes with POTEH: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for POTEH
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POTEH Gene

Localization for POTEH Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POTEH gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for POTEH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with POTEH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for POTEH Gene

Pathways & Interactions for POTEH Gene

SuperPathways for POTEH Gene

No Data Available

Gene Ontology (GO) - Biological Process for POTEH Gene

None

No data available for Pathways by source and SIGNOR curated interactions for POTEH Gene

Drugs & Compounds for POTEH Gene

No Compound Related Data Available

Transcripts for POTEH Gene

mRNA/cDNA for POTEH Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POTEH Gene

POTE ankyrin domain family, member H:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for POTEH
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for POTEH Gene

No ASD Table

Relevant External Links for POTEH Gene

GeneLoc Exon Structure for
POTEH
ECgene alternative splicing isoforms for
POTEH

Expression for POTEH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POTEH Gene

mRNA differential expression in normal tissues according to GTEx for POTEH Gene

This gene is overexpressed in Prostate (x30.4) and Testis (x20.7).

Protein differential expression in normal tissues from HIPED for POTEH Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POTEH Gene



Protein tissue co-expression partners for POTEH Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POTEH Gene:

POTEH

SOURCE GeneReport for Unigene cluster for POTEH Gene:

Hs.581075
genes like me logo Genes that share expression patterns with POTEH: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for POTEH Gene

Orthologs for POTEH Gene

This gene was present in the common ancestor of chordates.

Orthologs for POTEH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 84 (a)
ManyToMany
-- 34
  • 81 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 42 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
-- 34
  • 11 (a)
ManyToMany
-- 34
  • 7 (a)
ManyToMany
-- 34
  • 6 (a)
ManyToMany
-- 34
  • 2 (a)
ManyToMany
-- 34
ManyToMany
mouse
(Mus musculus)
Mammalia Gm1758 34
  • 33 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 4 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 8 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ANKRD7 34
  • 5 (a)
OneToMany
Species where no ortholog for POTEH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POTEH Gene

ENSEMBL:
Gene Tree for POTEH (if available)
TreeFam:
Gene Tree for POTEH (if available)

Paralogs for POTEH Gene

Variants for POTEH Gene

Sequence variations from dbSNP and Humsavar for POTEH Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000082583 -- 15,689,994(-) CTCCG(C/G)GTTTC upstream-variant-2KB
rs1000454450 -- 15,688,130(-) CAATC(A/T)CAAGT upstream-variant-2KB
rs1001727527 -- 15,694,327(-) CAGGG(G/T)TACAT intron-variant
rs1002095574 -- 15,702,114(-) TTAAG(C/T)CCGAA intron-variant
rs1002160125 -- 15,696,363(-) CTATT(A/G)CCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POTEH Gene

Variant ID Type Subtype PubMed ID
dgv168n111 CNV duplication 26073780
dgv2420n106 CNV duplication 24896259
dgv2529e59 CNV duplication 20981092
dgv2530e59 CNV duplication 20981092
dgv2531e59 CNV duplication 20981092
dgv2532e59 CNV duplication 20981092
dgv2533e59 CNV duplication 20981092
dgv4450n100 CNV gain 25217958
dgv4451n100 CNV gain+loss 25217958
dgv4452n100 CNV loss 25217958
dgv4453n100 CNV gain 25217958
dgv4455n100 CNV loss 25217958
dgv71n68 CNV gain 17160897
dgv7934n54 CNV gain 21841781
dgv98e203 CNV gain+loss 21179565
esv25550 CNV gain+loss 19812545
esv33426 CNV gain+loss 17666407
esv3369988 CNV duplication 20981092
esv3384201 CNV duplication 20981092
esv3411120 CNV duplication 20981092
esv3584775 CNV loss 24956385
esv3893421 CNV gain 25118596
esv995567 CNV loss 20482838
nsv1061008 CNV loss 25217958
nsv1076527 CNV duplication 25765185
nsv1076528 CNV duplication 25765185
nsv1077407 CNV duplication 25765185
nsv1077927 CNV duplication 25765185
nsv1110387 CNV duplication 24896259
nsv1118682 CNV duplication 24896259
nsv1141402 CNV duplication 24896259
nsv1141403 CNV duplication 24896259
nsv1141405 CNV duplication 24896259
nsv1146649 CNV duplication 26484159
nsv1150052 CNV duplication 26484159
nsv1152609 CNV duplication 26484159
nsv1153486 CNV duplication 26484159
nsv469815 CNV gain+loss 16826518
nsv471709 CNV gain+loss 15918152
nsv588004 CNV gain 21841781
nsv821525 CNV duplication 20802225
nsv953668 CNV duplication 24416366
nsv964647 CNV duplication 23825009
nsv966055 CNV duplication 23825009
nsv9866 CNV gain+loss 18304495

Variation tolerance for POTEH Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POTEH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POTEH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POTEH Gene

Disorders for POTEH Gene

Relevant External Links for POTEH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POTEH

No disorders were found for POTEH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POTEH Gene

Publications for POTEH Gene

  1. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (PMID: 15276201) Bera TK … Pastan I (Gene 2004) 2 3 4 60
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 4 60
  3. POTEH hypomethylation, a new epigenetic biomarker for glioma prognosis. (PMID: 21439273) Liu X … Li G (Brain research 2011) 2 3 60
  4. Expression of POTE protein in human testis detected by novel monoclonal antibodies. (PMID: 17996727) Ise T … Pastan I (Biochemical and biophysical research communications 2008) 22 60
  5. POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. (PMID: 12475935) Bera TK … Pastan I (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for POTEH Gene

Sources for POTEH Gene

Content
Loading form....