POTEG Gene
protein-coding GIFtS : 38
GCID: GC14 P019554
POTE ankyrin domain family, member G (Previous names: ANKRD26-like family C, member 2 ) (Previous symbol: A26C2 )
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Aliasesfor POTEG gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section This gene clusters with an RNA geneSubcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases POTE Ankyrin Domain Family, Member G 1 2 Prostate, Ovary, Testis-Expressed Protein On Chromosome 142 3 A26C21 2 3 ANKRD26-Like Family C Member 22 3 POTE-141 2 3 ACTBL12 POTE141 2 3 POTE222 CT104.41 2 Cancer/Testis Antigen Family 104, Member 42 POTE14alpha1 2 POTE Ankyrin Domain Family Member G2 ANKRD26-Like Family C, Member 21 2 Protein Expressed In Prostate, Ovary, Testis, And Placenta 142
External Ids: HGNC: 33896 1 Entrez Gene: 404785 2 Ensembl: ENSG00000222036 7 OMIM: 608916 5 UniProtKB: Q6S5H5 3 ORGUL members: NONCODE:n407913
Export aliases for POTEG gene to outside databases Previous GC identifer: GC14P018628
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Summariesfor POTEG gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor POTEG gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000014.8 NC_018925.1 NT_026437.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the POTEG gene promoter: PPAR-gamma1 ATF-2 Nkx2-2 Olf-1 PPAR-gamma2 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 Other transcription factors Search SABiosciences Chromatin IP Primers for POTEG Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POTEG
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2 POTEG Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14P019554: view genomic region
(about GC identifiers )
Start:
19,553,365 bp from pter
End:
19,590,078 bp from pter
Size:
36,714 bases
Orientation:
plus strand
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Proteinsfor POTEG gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: POTEG_HUMAN, Q6S5H5 (See
protein sequence )Recommended Name: POTE ankyrin domain family member G Size : 508 amino acids; 57096 Da
Sequence caution : Sequence=AAS58870.1; Type=Frameshift; Positions=308;
Secondary accessions : A1L153 A6NMI9 Q6S5H6 Q6S8J2Alternative splicing : 3 isoforms : Q6S5H5-3 Q6S5H5-2 Q6S5H5-4 (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for POTEG: NX_Q6S5H5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6S5H5 POTEG Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_001005356.1 ENSEMBL proteins: ENSP00000448581 ENSP00000448062 ENSP00000386971 Human Recombinant Protein Products for POTEG: POTEG Antibody Products: Assay Products for POTEG:
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Protein
Domains / Familiesfor POTEG gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
POTEG for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q6S5H5 ProtoNet protein and cluster: Q6S5H5
1 Blocks protein family : IPB002110 Ankyrin repeat signature UniProtKB/Swiss-Prot: POTEG_HUMAN, Q6S5H5 Similarity : Belongs to the POTE familySimilarity : Contains 5 ANK repeats
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Functionfor POTEG gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for POTEG OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for POTEGOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: POTEG (NM_001005356 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POTEG Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat POTEG
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Pathways & Interactionsfor POTEG gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POTEG STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for POTEG (ENSP00000386971 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor POTEG gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for POTEG Search CenterWatch for drugs/clinical trials and news about POTEG
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Transcriptsfor POTEG gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for POTEG gene (3 alternative transcripts): NM_001005357.1 NM_207513.2 NM_001005356.2 Unigene Cluster for POTEG:
POTE ankyrin domain family, member G Hs.711826 [show with all ESTs ] Unigene Representative Sequence: AY465171 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000552966 (uc010ahc.1 ) ENST00000547889 (uc001vva.1 ) ENST00000409832 (uc001vuz.1 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for POTEG OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for POTEGOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: POTEG (NM_001005356 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POTEG Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat POTEG
Additional cDNA sequence: AY462874.1 AY465171.1 AY465172.1 BC127623.1 NR_027480.1
5 DOTS entries : DT.91846532 DT.102838331
DT.100015986 DT.120764792 DT.120670748 24/25 AceView cDNA sequences (see all 25 ):
BU584133 AY338952 BU584404 AY462874 CD557737 AY465172 AA588848 BF477666 CD358418 BU160076 BC063888 BU584403 BU584020 CD243602 AA884098 BU584045 BU584009 BU584597 AI659600 AY466021 NM_001004053 BF511332 AA578971 AW294458 GeneLoc Exon Structure
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Expression for POTEG gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section POTEG expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGCAAAAACAAbout this image See POTEG Protein Expression from SPIRE MOPED and PaxDB SOURCE GeneReport for Unigene cluster: Hs.711826 SABiosciences Custom PCR Arrays for POTEG
Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for POTEGBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat POTEG QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat POTEG QIAGEN QuantiFast Probe-based Assays in human , mouse , rat POTEG
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Orthologsfor POTEG gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for POTEG gene from 3/8 species (see all 8 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
ANKRD626
Uncharacterized protein
11(a)
1 → many
1(26091172-26138404)
lizard (Anolis carolinensis)
Reptilia
ANKRD626
--
36(a)
1 → many
GL344195.1(39104-48393)
zebrafish (Danio rerio)
Actinopterygii
si:ch211-272n13.36
si:ch211-272n13.3
4(a)
1 → many
25(3581527-3655709)
ENSEMBL Gene Tree for POTEG (if available)TreeFam Gene Tree for POTEG (if available)
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Paralogsfor POTEG gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for POTEG gene POTEM 1 2 POTEH 1 2 POTEF 2 POTEI 2 ANKRD30A 2 ANKRD36 2 ANKRD7 2 POTEB 2 ANKRD30BL 2 ANKRD20A3 2 ENSG00000155282 2 ANKRD30B 2 ANKRD36C 2 ENSG00000266302 2 POTEJ 2 POTEC 2 ANKRD20A2 2 ANKRD26 2 ANKRD62 2 ANKRD18A 2 ENSG00000188219 2 ANKRD20A1 2 LOC100996331 2 CCDC144A 2 POTED 2 ANKRD20A4 2 ANKRD18B 2 LOC100288966 2 18/25 SIMAP similar genes for POTEG using alignment to 1 protein entry: POTEG_HUMAN (see all similar genes ):POTEM POTEH POTEC POTED POTEF POTEA POTEB ANKRD26P1 ANKRD30BL POTEI POTEE ANKRD19P ANKRD36B POTEJ ANKRD26 ANKRD18A ANKRD18B ANKRD30B
POTEG for paralogs About GeneDecksing
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Genomic Variantsfor POTEG gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 14 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for POTEG (19553365 - 19590078 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 9 variations for POTEG 7 CNVs : 71830 58655 2174 31953 7028 2256 0812 1 Indel : 40019 1 Inversion : 37153
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor POTEG gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
POTEG for disorders About GeneDecksing
OMIM gene information: 608916
OMIM disorders : --3 diseases for POTEG : About MalaCards prostatitis hepatocellular carcinoma carcinoma Export disorders for POTEG gene to outside databases
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Publicationsfor POTEG gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for POTEG gene integrated from 9 sources : (articles sorted by number of sources associating them with POTEG) Utopia : connect your pdf to the dynamic world of online information
Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (PubMed id 15276201) 1 , 2 Bera T.K.... Pastan I. (2004) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Identification of a novel actin isoform in hepatocellular carcinoma. (PubMed id 16824795) 1 Chang K.-W.... Yeh C.-T. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121) 2 Heilig R.... Weissenbach J. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800) 1 Dias Neto E....Simpson A.J.G. (2000)
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External Searches for POTEG gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing POTEG gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing POTEG gene
(According to HUGE )
About This Section --
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Specialized Databases showing POTEG gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for POTEG Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for POTEG gene: Search GeneIP for patents involving POTEG GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor POTEG gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for POTEG OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for POTEG OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for POTEG Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for POTEG OriGene 3'-UTR Clone for POTEG OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for POTEG OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for POTEG Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for POTEG OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for POTEG OriGene Custom Protein Services for POTEG OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POTEG Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POTEG QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POTEG QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat POTEG QIAGEN QuantiFast Probe-based Assays in human , mouse , rat POTEG QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat POTEG
Search Tocris compounds for POTEG
POTEG Proteins, Antibodies, CLIAs, and ELISAs
Search ThermoFisher Antibodies for POTEG
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat POTEG
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Aliases for POTEG
Databases for POTEG
Disorders / Diseases for POTEG
Domains / Families for POTEG
Drugs / Compounds for POTEG
Expression for POTEG
Function for POTEG
Genomic Views for POTEG
Intellectual Property for POTEG
Orthologs for POTEG
Paralogs for POTEG
Pathways / Interactions for POTEG
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Search Box for POTEG
Summaries for POTEG
Transcripts for POTEG
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