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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POTEG Gene

protein-coding   GIFtS: 38
GCID: GC14P019554

POTE ankyrin domain family, member G

(Previous names: ANKRD26-like family C, member 2 )
(Previous symbol: A26C2)
 Explore 3 diseases affiliated with
POTEG via our new
 Human Malady Compendium 
Biological research products
for POTEG
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
POTE Ankyrin Domain Family, Member G1 2     Prostate, Ovary, Testis-Expressed Protein On Chromosome 142 3
A26C21 2 3     ANKRD26-Like Family C Member 22 3
POTE-141 2 3     ACTBL12
POTE141 2 3     POTE222
CT104.41 2     Cancer/Testis Antigen Family 104, Member 42
POTE14alpha1 2     POTE Ankyrin Domain Family Member G2
ANKRD26-Like Family C, Member 21 2     Protein Expressed In Prostate, Ovary, Testis, And Placenta 142

External Ids:    HGNC: 338961   Entrez Gene: 4047852   Ensembl: ENSG000002220367   OMIM: 6089165   UniProtKB: Q6S5H53   
ORGUL members:         
NONCODE:n407913    

Export aliases for POTEG gene to outside databases

Previous GC identifer: GC14P018628


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POTEG gene promoter:
         PPAR-gamma1   ATF-2   Nkx2-2   Olf-1   PPAR-gamma2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for POTEG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POTEG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

POTEG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POTEG gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P019554:  view genomic region     (about GC identifiers)

Start:
19,553,365 bp from pter      End:
19,590,078 bp from pter
Size:
36,714 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: POTEG_HUMAN, Q6S5H5 (See protein sequence)
Recommended Name: POTE ankyrin domain family member G  
Size: 508 amino acids; 57096 Da
Sequence caution: Sequence=AAS58870.1; Type=Frameshift; Positions=308;
Secondary accessions: A1L153 A6NMI9 Q6S5H6 Q6S8J2
Alternative splicing: 3 isoforms:  Q6S5H5-3   Q6S5H5-2   Q6S5H5-4   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for POTEG: NX_Q6S5H5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6S5H5

  • POTEG Protein expression data from MOPED and PaxDb:    About this image 
    POTEG Protein Expression
    REFSEQ proteins: NP_001005356.1  
    ENSEMBL proteins: 
     ENSP00000448581   ENSP00000448062   ENSP00000386971  

    Human Recombinant Protein Products for POTEG: 
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    Uscn Proteins for POTEG


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    Uscn ELISAs and CLIAs for POTEG


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    POTEG for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q6S5H5

    ProtoNet protein and cluster: Q6S5H5

    1 Blocks protein family: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: POTEG_HUMAN, Q6S5H5
    Similarity: Belongs to the POTE family
    Similarity: Contains 5 ANK repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for POTEG 

    miRNA
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    Inhib. RNA
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    In Situ Assay
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    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for POTEG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POTEG

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for POTEG (ENSP000003869714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POTEG
    Search CenterWatch for drugs/clinical trials and news about POTEG 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POTEG gene (3 alternative transcripts): 
    NM_001005357.1  NM_207513.2  NM_001005356.2  

    Unigene Cluster for POTEG:

    POTE ankyrin domain family, member G
    Hs.711826  [show with all ESTs]
    Unigene Representative Sequence: AY465171
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552966(uc010ahc.1) ENST00000547889(uc001vva.1) ENST00000409832(uc001vuz.1)


    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POTEG
    OriGene shRNA RFP: POTEG
    OriGene siRNA: POTEG
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    Sirion Biotech Custom design and validation of potent shRNA sequences against POTEG 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POTEG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: POTEG (NM_001005356)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POTEG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POTEG 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POTEG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POTEG

    Additional cDNA sequence: 

    AY462874.1 AY465171.1 AY465172.1 BC127623.1 NR_027480.1 

    5 DOTS entries:

    DT.91846532  DT.102838331  DT.100015986  DT.120764792  DT.120670748 

    24/25 AceView cDNA sequences (see all 25):

    BU584133 AY338952 BU584404 AY462874 CD557737 AY465172 AA588848 BF477666 
    CD358418 BU160076 BC063888 BU584403 BU584020 CD243602 AA884098 BU584045 
    BU584009 BU584597 AI659600 AY466021 NM_001004053 BF511332 AA578971 AW294458 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POTEG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCAAAAACA
    POTEG Expression
    About this image
    See POTEG Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.711826
        SABiosciences Custom PCR Arrays for POTEG

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POTEG
    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for POTEG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for POTEG gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ANKRD626
    Uncharacterized protein
    11(a)
    1 → many
    1(26091172-26138404)
    lizard
    (Anolis carolinensis)
    Reptilia ANKRD626
    --
    36(a)
    1 → many
    GL344195.1(39104-48393)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-272n13.36
    si:ch211-272n13.3
    4(a)
    1 → many
    25(3581527-3655709)


    ENSEMBL Gene Tree for POTEG (if available)
    TreeFam Gene Tree for POTEG (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POTEG gene
    POTEM1 2  POTEH1 2  POTEF2  POTEI2  ANKRD30A2  ANKRD362  ANKRD72  POTEB2  
    ANKRD30BL2  ANKRD20A32  ENSG000001552822  ANKRD30B2  ANKRD36C2  ENSG000002663022  POTEJ2  POTEC2  
    ANKRD20A22  ANKRD262  ANKRD622  ANKRD18A2  ENSG000001882192  ANKRD20A12  LOC1009963312  CCDC144A2  
    POTED2  ANKRD20A42  ANKRD18B2  LOC1002889662  
    18/25 SIMAP similar genes for POTEG using alignment to 1 protein entry:     POTEG_HUMAN(see all similar genes):
    POTEM    POTEH    POTEC    POTED    POTEF    POTEA
    POTEB    ANKRD26P1    ANKRD30BL    POTEI    POTEE    ANKRD19P
    ANKRD36B    POTEJ    ANKRD26    ANKRD18A    ANKRD18B    ANKRD30B

    POTEG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/265 NCBI SNPs in POTEG are shown (see all 265    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs286364251,2
    F--19552771(+) ACGCGC/TGGCAG 2 -- us2k12Minor allele frequency- T:0.50NA 4
    rs285732541,2
    C--19552796(+) TGTAAG/CGGCTT 2 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1405402421,2
    --19552989(+) TGCGTA/GACGGC 2 -- us2k10--------
    rs1996770861,2
    --19553372(+) TAGACA/GCGATC 2 -- ut51 nc-transcript-variant0--------
    rs2016771211,2
    F--19553451(+) TGCCTC/TCTCTG 3 S F mis11Minor allele frequency- T:0.00EU 1105
    rs2002567101,2
    F--19553494(+) GGCAAG/ATGGTG 3 /K nc-transcript-variantsyn11Minor allele frequency- A:0.00EU 953
    rs1427023161,2
    C,F--19553524(+) TGCAGG/AGGGAG 3 /R syn12Minor allele frequency- A:0.03NA EU 3571
    rs794890201,2
    C,F--19553556(+) TTCTGG/AAGACC 3 /E /G mis12Minor allele frequency- A:0.03NA EU 5181
    rs1397048831,2
    C,F--19553586(+) GACACT/CCAGGA 3 /P /L mis11Minor allele frequency- C:0.00NA 4418
    rs1435652191,2
    C,F--19553608(+) AAGTGG/ATGCCG 3 /* /W stg11Minor allele frequency- A:0.00NA 4424

    HapMap Linkage Disequilibrium report for POTEG (19553365 - 19590078 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for POTEG
         7 CNVs: 71830 58655 2174 31953 7028 2256 0812
         1 Indel: 40019
         1 Inversion: 37153

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    POTEG for disorders           About GeneDecksing

    OMIM gene information: 608916    OMIM disorders: --

    3 diseases for POTEG:    About MalaCards
    prostatitis    hepatocellular carcinoma    carcinoma


    Export disorders for POTEG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POTEG gene integrated from 9 sources:
    (articles sorted by number of sources associating them with POTEG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (PubMed id 15276201)1, 2 Bera T.K.... Pastan I. (2004)
    2. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    3. Identification of a novel actin isoform in hepatocellular carcinoma. (PubMed id 16824795)1 Chang K.-W.... Yeh C.-T. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 404785 HGNC: 33896 AceView: POTE14.1 Ensembl:ENSG00000222036 euGenes: HUgn404785
    ECgene: POTEG H-InvDB: POTEG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POTEG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POTEG gene:
    Search GeneIP for patents involving POTEG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
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     POTEG Proteins, Antibodies, CLIAs, and ELISAs
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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